MCID: GST009
MIFTS: 58

Gastroschisis

Categories: Fetal diseases, Gastrointestinal diseases, Liver diseases, Rare diseases, Respiratory diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Gastroschisis

MalaCards integrated aliases for Gastroschisis:

Name: Gastroschisis 57 11 19 42 58 53 43 14 38 16 71 75 31 33
Laparoschisis 19 58 75 33
Congenital Fissure of the Abdominal Cavity 19
Abnormality of the Abdominal Wall 5
Congenital Para-Umbilical Hernia 33
Congenital Omphalocele 71
Abdominal Wall Defect 42
Hernia, Abdominal 42
Abdominal Hernia 42
Coelioschisis 33
Coeloschisis 33
Omphalocele 42
Celoschisis 33

Characteristics:


Inheritance:

Autosomal recessive vs multifactorial 57

Prevelance:

1-5/10000 (Europe, Austria, Belgium, Croatia, Denmark, France, Germany, Ireland, Malta, Netherlands, Norway, Poland, Portugal, Switzerland, United Kingdom, Europe) 1-9/100000 (Hungary, Italy, Spain, Ukraine) 58

Age Of Onset:

Antenatal 58

Age Of Death:

normal life expectancy 58

Classifications:

Orphanet: 58  
Rare gastroenterological diseases
Developmental anomalies during embryogenesis


External Ids:

Disease Ontology 11 DOID:11044
OMIM® 57 230750
ICD9CM 34 756.73
MeSH 43 D020139
NCIt 49 C84725
SNOMED-CT 68 72951007
MESH via Orphanet 44 D020139
ICD10 via Orphanet 32 Q79.3
UMLS via Orphanet 72 C0265706
Orphanet 58 ORPHA2368
MedGen 40 C0265706
ICD11 33 551758329
UMLS 71 C0265706 C0795690

Summaries for Gastroschisis

MedlinePlus Genetics: 42 An abdominal wall defect is an opening in the abdomen through which various abdominal organs can protrude. This opening varies in size and can usually be diagnosed early in fetal development, typically between the tenth and fourteenth weeks of pregnancy. There are two main types of abdominal wall defects: omphalocele and gastroschisis. Omphalocele is an opening in the center of the abdominal wall where the umbilical cord meets the abdomen. Organs (typically the intestines, stomach, and liver) protrude through the opening into the umbilical cord and are covered by the same protective membrane that covers the umbilical cord. Gastroschisis is a defect in the abdominal wall, usually to the right of the umbilical cord, through which the large and small intestines protrude (although other organs may sometimes bulge out). There is no membrane covering the exposed organs in gastroschisis.Fetuses with omphalocele may grow slowly before birth (intrauterine growth retardation) and they may be born prematurely. Individuals with omphalocele frequently have multiple birth defects, such as a congenital heart defect. Additionally, underdevelopment of the lungs is often associated with omphalocele because the abdominal organs normally provide a framework for chest wall growth. When those organs are misplaced, the chest wall does not form properly, providing a smaller than normal space for the lungs to develop. As a result, many infants with omphalocele have respiratory insufficiency and may need to be supported with a machine to help them breathe (mechanical ventilation). Rarely, affected individuals who have breathing problems in infancy experience recurrent lung infections or asthma later in life. Affected infants often have gastrointestinal problems including a backflow of stomach acids into the esophagus (gastroesophageal reflux) and feeding difficulty; these problems can persist even after treatment of omphalocele. Large omphaloceles or those associated with multiple additional health problems are more often associated with fetal death than cases in which omphalocele occurs alone (isolated).Omphalocele is a feature of many genetic syndromes. Nearly half of individuals with omphalocele have a condition caused by an extra copy of one of the chromosomes in each of their cells (trisomy). Up to one-third of people born with omphalocele have a genetic condition called Beckwith-Wiedemann syndrome. Affected individuals may have additional signs and symptoms associated with these genetic conditions.Individuals who have gastroschisis rarely have other birth defects and seldom have chromosome abnormalities or a genetic condition. Most affected individuals experience intrauterine growth retardation and are small at birth; many affected infants are born prematurely.With gastroschisis, the protruding organs are not covered by a protective membrane and are susceptible to damage due to direct contact with amniotic fluid in the womb. Components of the amniotic fluid may trigger immune responses and inflammatory reactions against the intestines that can damage the tissue. Constriction around exposed organs at the abdominal wall opening late in fetal development may also contribute to organ injury. Intestinal damage causes impairment of the muscle contractions that move food through the digestive tract (peristalsis) in most children with gastroschisis. In these individuals, peristalsis usually improves in a few months and intestinal muscle contractions normalize. Rarely, children with gastroschisis have a narrowing or absence of a portion of intestine (intestinal atresia) or twisting of the intestine. After birth, these intestinal malformations can lead to problems with digestive function, further loss of intestinal tissue, and a condition called short bowel syndrome that occurs when areas of the small intestine are missing, causing dehydration and poor absorption of nutrients. Depending on the severity of the condition, intravenous feedings (parenteral nutrition) may be required.The health of an individual with gastroschisis depends largely on how damaged his or her intestine was before birth. When the abdominal wall defect is repaired and normal intestinal function is recovered, the vast majority of affected individuals have no health problems related to the repaired defect later in life.

MalaCards based summary: Gastroschisis, also known as laparoschisis, is related to ileus and nutritional deficiency disease. An important gene associated with Gastroschisis is AEBP1 (AE Binding Protein 1), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Bupivacaine and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and lung, and related phenotypes are gastroschisis and intestinal atresia

GARD: 19 Gastroschisis is a birth defect that occurs when a baby's intestines extend outside of the body through a hole next to the belly button. This type of defect is known as an abdominal wall defect. Sometimes other organs are also involved. The exact cause of a Gastroschisis is usually not known, but it is more common in babies born to young mothers or to mothers who may have used alcohol or tobacco during their pregnancies. Gastroschisis is typically diagnosed on routine ultrasound examinations before a baby is born. These babies may need to be born in hospitals with specialists who are experienced in treating Gastroschisis. Complications from Gastroschisis can include intestinal problems, breathing difficulties, and infection. Other complications include incomplete bowel (atresia), destruction (necrosis), perforation or twisting (volvulos).

OMIM®: 57 Gastroschisis is a congenital defect of the abdominal wall that occurs laterally to, and often to the right of, a normally closed umbilical ring. Visceral organs that herniate through the defect are not covered by a membrane. Gastroschisis is distinct from omphalocele (164750), which is characterized by herniation of abdominal contents through the base of the umbilical cord; in omphalocele, the visceral organs are covered by membranes (summary by Mastroiacovo et al., 2007). Both omphalocele and gastroschisis, when they occur without other malformations, are probably multifactorial (Baird and MacDonald, 1981). (230750) (Updated 24-Oct-2022)

Orphanet: 58 A rare abdominal wall malformation characterized by the bowel protruding from the fetal abdomen on the right lateral base of the umbilical cord, and without a covering sac.

Wikipedia: 75 Gastroschisis is a birth defect in which the baby's intestines extend outside of the abdomen through a... more...

Related Diseases for Gastroschisis

Diseases related to Gastroschisis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 783)
# Related Disease Score Top Affiliating Genes
1 ileus 30.9 IL6 IL1B ICAM1
2 nutritional deficiency disease 30.6 MTHFR IL6 F2
3 necrotizing fasciitis 30.4 IL6 IL1B F2
4 cellulitis 30.4 IL6 IL1B F2
5 urinary tract infection 30.3 IL6 IL1B F2 CST3
6 inguinal hernia 30.2 MMP1 IL6 F2
7 alcoholic liver cirrhosis 30.2 IL6 IL1B F2
8 budd-chiari syndrome 30.2 MTHFR F5 F2
9 thrombophlebitis 30.2 MTHFR F5 F2
10 bilirubin metabolic disorder 30.1 IL6 IL1B F2 CYP1A2
11 alcohol use disorder 30.1 IL6 IL1B F2
12 hemorrhoid 30.0 IL6 IL1B F2
13 adult respiratory distress syndrome 30.0 MPO IL6 IL1B F5
14 substance abuse 30.0 IL6 IL1B F2
15 urinary tract obstruction 30.0 IL6 IL1B CST3
16 respiratory failure 30.0 MPO IL6 IL1B ICAM1 F2
17 acute kidney failure 30.0 NPPA IL6 F2 CST3
18 thrombophilia due to thrombin defect 30.0 MTHFR F5 F2
19 pericardial effusion 30.0 NPPA IL6 F2
20 patent foramen ovale 29.9 NPPA MTHFR IL6 F5 F2
21 viral pneumonia 29.9 IL6 IL1B F2
22 aspiration pneumonia 29.9 IL6 IL1B F2
23 toxoplasmosis 29.9 IL6 IL1B F2
24 thrombosis 29.9 NOS3 MTHFR F5 F2
25 persistent fetal circulation syndrome 29.9 NOS3 IL6 IL1B
26 thrombophilia 29.9 NOS3 MTHFR F5 F2
27 disseminated intravascular coagulation 29.9 IL6 F5 F2
28 bronchiolitis 29.8 IL6 IL1B ICAM1
29 placental insufficiency 29.8 IL6 F2 CST3
30 bronchopneumonia 29.8 MPO IL6 IL1B
31 liver cirrhosis 29.8 NPPA IL6 F2 CYP1A2
32 acute pancreatitis 29.7 MPO IL6 IL1B ICAM1
33 neural tube defects 29.7 MTHFR MPO F2 CYP1A2 ACHE
34 exanthem 29.7 MPO IL6 IL1B F2
35 pelvic organ prolapse 29.7 MMP8 MMP3 MMP1
36 patent ductus arteriosus 1 29.7 MTHFR IL6 F2
37 duodenal ulcer 29.6 MPO IL6 IL1B
38 hemorrhagic disease 29.6 MPO F5 F2
39 chorioamnionitis 29.6 MMP8 MMP1 IL6 IL1B
40 bacterial pneumonia 29.6 MPO IL6 IL1B
41 tonsillitis 29.5 MPO IL6 IL1B
42 appendicitis 29.5 MPO IL6 IL1B
43 kidney disease 29.5 NPPA NOS3 MTHFR IL6 CST3 BMP6
44 endometriosis 29.5 MMP3 MMP1 IL6 IL1B CYP1A1
45 peritonitis 29.5 MPO MMP8 IL6 IL1B ICAM1 F2
46 speech and communication disorders 29.5 IL6 IL1B F2 ACHE
47 bronchitis 29.4 MPO IL6 IL1B CYP1A1
48 pre-eclampsia 29.4 NPPA NOS3 MTHFR IL6 IL1B ICAM1
49 preterm premature rupture of the membranes 29.3 MMP8 MMP3 MMP1 IL6 IL1B
50 basal cell carcinoma 29.2 MTHFR MMP8 MMP3 MMP1 IL6 CYP1A1

Graphical network of the top 20 diseases related to Gastroschisis:



Diseases related to Gastroschisis

Symptoms & Phenotypes for Gastroschisis

Human phenotypes related to Gastroschisis:

58 30
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 gastroschisis 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001543
2 intestinal atresia 58 30 Frequent (33%) Frequent (79-30%)
HP:0011100
3 abnormality of mesentery morphology 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100016
4 abdominal wall defect 30 HP:0010866

Symptoms via clinical synopsis from OMIM®:

57 (Updated 24-Oct-2022)
Abdomen:
gastroschisis
anterior abdominal wall defect

Clinical features from OMIM®:

230750 (Updated 24-Oct-2022)

GenomeRNAi Phenotypes related to Gastroschisis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.19 ACHE ADD1 AEBP1 BMP1 BMP6 CST3
2 no effect GR00402-S-2 10.19 ACHE ADD1 AEBP1 BMP1 BMP6 CYP1A1
3 Increased shRNA abundance GR00327-A 9.35 ADD1 CYP1A1 F5 MMP3 MTHFR

MGI Mouse Phenotypes related to Gastroschisis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.37 ACHE ADD1 AEBP1 BMP1 BMP6 CST3
2 nervous system MP:0003631 10.21 ACHE ADD1 BMP6 CST3 F2 F5
3 growth/size/body region MP:0005378 10.17 ACHE ADD1 AEBP1 BMP1 BMP6 CYP1A1
4 cardiovascular system MP:0005385 10.1 ACHE AEBP1 BMP1 BMP6 CST3 F2
5 muscle MP:0005369 10.06 ACHE BMP1 CST3 F2 ICAM1 IL6
6 neoplasm MP:0002006 10 CST3 CYP1A2 ICAM1 IL1B IL6 MMP1
7 immune system MP:0005387 9.93 ACHE BMP1 CYP1A1 F2 ICAM1 IL1B
8 hematopoietic system MP:0005397 9.77 ACHE ADD1 BMP1 BMP6 CYP1A1 F2
9 mortality/aging MP:0010768 9.5 ACHE ADD1 AEBP1 BMP1 CST3 CYP1A1

Drugs & Therapeutics for Gastroschisis

Drugs for Gastroschisis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
4
Morphine Approved, Investigational Phase 4 57-27-2 5288826
5
Glycerin Approved, Investigational Phase 4 56-81-5 753
6 Anesthetics Phase 4
7 Pharmaceutical Solutions Phase 4
8 Anesthetics, Local Phase 4
9 Analgesics Phase 4
10 Cyclooxygenase Inhibitors Phase 4
11 Antirheumatic Agents Phase 4
12 Analgesics, Opioid Phase 4
13 Antipyretics Phase 4
14 Anti-Inflammatory Agents, Non-Steroidal Phase 4
15 Analgesics, Non-Narcotic Phase 4
16 Anti-Inflammatory Agents Phase 4
17
Ketorolac Tromethamine Phase 4
18 Protective Agents Phase 4
19
Metoclopramide Approved, Investigational Phase 3 364-62-5 4168
20
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
21
bilirubin Phase 2, Phase 3 635-65-4 5280352
22 Fat Emulsions, Intravenous Phase 2, Phase 3
23 Omega 3 Fatty Acid Phase 2, Phase 3
24 Gastrointestinal Agents Phase 3
25 Antiemetics Phase 3
26 Dopamine Antagonists Phase 3
27 Dopamine Agents Phase 3
28 Neurotransmitter Agents Phase 3
29 Immunosuppressive Agents Phase 2
30 Immunologic Factors Phase 2
31 Dialysis Solutions Phase 1
32
Acetylcholine Approved, Investigational 51-84-3 187
33
Glycopyrronium Approved, Investigational, Vet_approved 596-51-0, 740028-90-4 3494
34
Remifentanil Approved 132875-61-7 60815
35
Neostigmine Approved, Vet_approved 59-99-4 4456 5824
36
Ropivacaine Approved 84057-95-4 71273 175805
37
Sodium oxybate Approved 502-85-2 23663870
38
Mycophenolic acid Approved, Investigational Early Phase 1 24280-93-1 446541
39
Prednisone Approved, Vet_approved Early Phase 1 53-03-2 5865
40
Tacrolimus Approved, Investigational Early Phase 1 104987-11-3 6473866 445643
41
Clavulanic acid Approved, Vet_approved 58001-44-8 5280980
42
Amoxicillin Approved, Vet_approved 26787-78-0 33613
43 Fluorides
44
abobotulinumtoxinA
45 Botulinum Toxins, Type A
46 Cholinergic Agents
47 Botulinum Toxins
48 Chrysarobin
49 Bifidobacterium
50 Antibiotics, Antitubercular

Interventional clinical trials:

(show top 50) (show all 99)
# Name Status NCT ID Phase Drugs
1 Liposomal Bupivacaine (Exparel) for Postoperative Pain Control for Open and Laparoscopic Abdominal Hernia Repair Completed NCT02128646 Phase 4 EXPAREL;Ketorolac
2 Results of Open Mesh Versus Suture Repair in Treatment of Abdominal Wall (Multicentric, Prospective, Randomised, Internet-based, Clinical Trial) Completed NCT01018524 Phase 4
3 Assistance Robotics for the Surgical Treatment of the Abdominal Wall Hernia Completed NCT00908193 Phase 4
4 A Randomized, Prospective, Double-blind, Multi-Center Study To Examine And Compare The Outcomes Associated With The Use Of Flex HD®, A Human Acellular Dermal Matrix, And Strattice™, A Porcine Acellular Dermal Matrix Allograft, When Used As A Reinforcing Material In The Repair Of Large Abdominal Wall Hernias By A Component Separation Technique Completed NCT01987700 Phase 4
5 Evaluation of the Safety and Efficacy of EXPAREL® When Infiltrated Into the Transversus Abdominis Plane (TAP) for Prolonged Postoperative Analgesia in Subjects Undergoing Unilateral Abdominal Hernia Repair Completed NCT01801124 Phase 4 EXPAREL
6 Role of Scheduled Intravenous Acetaminophen for Postoperative Pain Management in an Enhanced Recovery After Surgery (ERAS) Population: A Prospective, Randomized, Double-Blind and Placebo-Controlled Clinical Trial Completed NCT03198871 Phase 4 Acetaminophen Injectable Product;Sodium Chloride 0.9%, Intravenous
7 A Longitudinal Prospective Outcomes Study of Laparoscopic Abdominal Wall Hernia Repair Using Symbotex™ Composite Mesh Completed NCT02341430 Phase 4
8 Evaluation of Routine Administration of Glycerin Suppositories to Improve Bowel Function in Patients With Uncomplicated Gastroschisis Terminated NCT03355326 Phase 4 Glycerin Suppository
9 The Use of Gastrografin to Help Alleviate Bowel Obstruction Related to Poor Bowel Motility in Gastroschisis Patients. Withdrawn NCT03334578 Phase 4 Gastrografin
10 Randomized Trial of AMNIOECHANGE in Gastroschisis Affected Foetuses Unknown status NCT00127946 Phase 3
11 Fish Oil Lipid Emulsion for the Treatment of Parenteral-Nutrition-Associated Liver Disease in Infants Completed NCT02370251 Phase 2, Phase 3 Omegaven
12 Gastroschisis Outcomes of Delivery (GOOD) Study Recruiting NCT02774746 Phase 3
13 The Use of Metoclopramide vs. Placebo in Infants With Gastroschisis. A Pilot Double Blind Randomized Controlled Trial Terminated NCT02098915 Phase 3 intravenous metoclopramide
14 A Multi-Centre, Prospective Randomized Trial to Evaluate Routine Use of a Silastic Spring-Loaded Silo for Infants With Gastroschisis Completed NCT00539292 Phase 2
15 Abdominal Wall Transplantation for the Reconstruction of Abdominal Wall Defects as Adjunct to Abdominal Solid Organ Transplantation Recruiting NCT03310905 Phase 2 Immunosuppressive Agents
16 The Effect of Multimodal Pain Therapy After Hernia Repair Withdrawn NCT03792295 Phase 2 acetominophen, ibuprofen, oxycodone;Oxycodone
17 Direct Peritoneal Resuscitation in Gastroschisis Terminated NCT03205553 Phase 1 Peritoneal Dialysis Solution/Dextrose 1.5%
18 An Open-label, Single-arm, Phase 1 Study Examining the Safety and Efficacy of Fibrin Sealant Plus Silver Microparticles to Prevent Incisional Hernias (HiP_1 Trial) Following Abdominal Surgery Withdrawn NCT02584153 Phase 1 Fibrin Sealant;Silver Microparticles
19 Developing and Implementing an Interventional Bundle to Reduce Mortality From Gastroschisis in Low-Resource Settings Unknown status NCT03724214
20 The Effect of Music Therapy On Infants Born With Gastroschisis Unknown status NCT01469208
21 Functional Magnetic Resonance Imaging - Blood Oxygenation Level Dependent (MRI-BOLD) of the Feta Lung in Congenital Diaphragmatic and Parietal Malformations Unknown status NCT04186039
22 Ostomy in Continuity or Conventional Ileostomy for Complex Pediatric Intestinal Diseases: a Retrospective Multicentric Analysis Unknown status NCT04213976
23 Utility of a Supraaponeurotic Mesh as Prophylaxis of the Midline Eventration After an Oncological Colorrectal Resection Unknown status NCT03520465
24 Post-Operative Pain After Laparoscopic Ventral Hernia Repair, Impact of Mesh Impregnation With Bupivacaine Solution vs. Normal Saline Solution Unknown status NCT03035617 Bupivacaine
25 A Study of the Intra-operative Biomechanics in Complex Abdominal Wall Reconstruction: Do Changes in Abdominal Biomechanics Correlate With Significant Changes in Lung Compliance and Respiratory Function? Unknown status NCT03296475
26 Evaluation of TAR Technique in the Treatment of Huge Abdominal Wall Hernia and Large Abdominal Wall Defect With or Without Botox Injection . Unknown status NCT04419844
27 Effect of Botox Injection on Lateral Abdominal Wall Muscles After Major Open Abdominal Surgery Unknown status NCT04422197
28 Posterior Component Separation With Transversus Abdominis Muscle Release Versus Mesh Only Repair in the Treatment of Complex Ventral Wall Hernia: A Randomized Controlled Trial Unknown status NCT04516031
29 Study for the Evaluation of the Efficiency of a Device for the Diagnosis of an Internal Rectal Prolapse, a Pelvic Floor Ptosis and for the Determination of an Internal Hernia Into the Douglas Pouch Unknown status NCT00836680
30 Morbidity of Abdominal Wall Hernia Reconstruction With Mesh: Study of Environmental Risk Factors in the Operating Room in the CHRU of Nancy- a Prospective Study Unknown status NCT04174976
31 Mesh Used Repairs in Emergency Abdominal Wall Hernias Unknown status NCT01578538
32 Randomized Clinical Trial Comparing Open Preperitoneal Mesh, Retromuscular Mesh and Suture Repair for Abdominal Wall Hernias Less Than 3 cm Diameter Unknown status NCT03255239
33 Regional Haemoglobin Oxygen Saturation in the Splanchnic Circulation in Neonates With Gastroschisis; Quantifying and Qualifying the Role for Routine Monitoring Completed NCT03533439
34 Clinical and Biological Outcomes of Human Milk and Formula Intake After Gastroschisis Repair Completed NCT02575846
35 Bedside Silo Versus Attempted Operative Closure for Gastroschisis Completed NCT01506531
36 Probiotics in Infants With Gastroschisis Completed NCT01316510
37 Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries: A Multi-Centre, International, Prospective Cohort Study Completed NCT03666767
38 The Role of Indocyanine Green Angiography Fluorescence on Intestinal Resections in Pediatric Surgery. Completed NCT04020939 Indocyanine Green
39 Pilot Study on Sham Feeding in Post-operative Gastrointestinal Surgery Infants Completed NCT03350022
40 Health Related Quality of Life of Patients With Abdominal Wall Defects Completed NCT03960320
41 Paediatric Surgery Across Sub-Saharan Africa: A Multi-Centre Prospective Cohort Study Completed NCT03185637
42 Complex Abdominal Wall Reconstruction With Polyvinylidene (PVDF) Mesh in the Setting of Active Infection: a Prospective Case-control Series. Completed NCT05061264
43 Observational, Retrospective, Multi-center Clinical Study on the Safety of SAFIL® MESH in Patients Undergoing Reinforcement of Soft Tissues After Abdominal Wall Surgery or Other Fascial Defects Completed NCT04947202
44 The Use of Synthetic Mesh in Contaminated and Infected Abdominal Wall Repairs: Challenging the Dogma of an Absolute Contra-indication. A Long-term Prospective Clinical Trial Completed NCT03702153
45 Stepwise for the Treatment of Lateral Incisional Hernias Completed NCT05205213
46 A Prospective Multicentre Study Evaluating the Outcomes of the Abdominal Wall Dehiscence Repair Using Posterior Component Separation With Transversus Abdominis Muscle Release Reinforced by a Retro-muscular Mesh - Filling a Step Completed NCT05278117
47 ENHANCE: A Prospective Long-term EvaluatioN of the Use of Permacol™ Biological Implant in tHe Repair of Complex AbdomiNal Wall CasEs Completed NCT01268514
48 Nationwide Long-term Outcome Surveillance of Physiomesh® vs. Other Meshes in Laparoscopic Incisional Hernia Repair Completed NCT03846661
49 Prevalence of Sarcopenia and Undernutrition in Patients With Cirrhosis and Abdominal Hernia Completed NCT03458845
50 A Post-Market, Prospective, Multi-Center, Single-Arm Clinical Investigation of Phasix™ Mesh for VHWG Grade 3 Midline Hernia Repair Completed NCT02720042

Search NIH Clinical Center for Gastroschisis

Cochrane evidence based reviews: gastroschisis

Genetic Tests for Gastroschisis

Anatomical Context for Gastroschisis

Organs/tissues related to Gastroschisis:

MalaCards : Small Intestine, Liver, Lung, Heart, Breast, Bone Marrow, Skeletal Muscle

Publications for Gastroschisis

Articles related to Gastroschisis:

(show top 50) (show all 5749)
# Title Authors PMID Year
1
Gastroschisis: a gene-environment model involving the VEGF-NOS3 pathway. 62 57
18655103 2008
2
Development of gastroschisis: review of hypotheses, a novel hypothesis, and implications for research. 62 57
17230493 2007
3
Gastroschisis and associated defects: an international study. 62 57
17357116 2007
4
Novel risk factor in gastroschisis: change of paternity. 62 57
17163540 2007
5
Selected gene polymorphisms and their interaction with maternal smoking, as risk factors for gastroschisis. 62 57
17051589 2006
6
Omphalocele and gastroschisis in Europe: a survey of 3 million births 1980-1990. EUROCAT Working Group. 62 57
8533813 1995
7
Monozygotic twins discordant for gastroschisis: case report and review of the literature of twins and familial occurrence of gastroschisis. 62 57
7802013 1994
8
Familial cases of gastroschisis in a population-based registry. 62 57
8465852 1993
9
Genetic-epidemiologic study of omphalocele and gastroschisis: evidence for heterogeneity. 62 57
1481831 1992
10
Familial abdominal wall defects. 62 57
2530900 1989
11
Familial gastroschisis and omphalocele. 62 57
6211093 1982
12
An epidemiologic study of congenital malformations of the anterior abdominal wall in more than half a million consecutive live births. 62 57
6454342 1981
13
Familial occurrence of gastroschisis. Four new cases and review of the literature. 62 57
155396 1979
14
Alterations of enteric nerve plexus in experimental gastroschisis: is there a delay in the maturation? 53 62
14577076 2003
15
Scanning gel densitometry of amniotic fluid acetylcholinesterase and butyrylcholinesterase: quantification of 'faint-positive' bands in fetal malformations. 53 62
7647148 1995
16
The association between 'faint-positive' amniotic fluid acetylcholinesterase and fetal malformations. 53 62
8140072 1993
17
Amniotic fluid acetylcholinesterase is found in gastroschisis but not omphalocele. 53 62
8240688 1993
18
Fabrication of high-strength, flexible, porous collagen-based scaffolds to promote tissue regeneration. 62
35991626 2022
19
Surgeon Variation in the Application of Robotic Technique for Abdominal Hernia Repair: A Mixed-Methods Study. 62
35717796 2022
20
Mid-trimester dilated fetal bowel leading to diagnosis of interstitial duplication 46,XX,dup(8)(q21.13q21.2) associated with extensive neonatal jejuno-ileal atresia. 62
36132065 2022
21
Maternal periconceptional alcohol consumption and gastroschisis in the National Birth Defects Prevention Study, 1997-2011. 62
35437856 2022
22
Hospital Variation in Surgical Technique for Repair of Uncomplicated Gastroschisis. 62
35549512 2022
23
Elective Delivery versus Expectant Management for Gastroschisis: A Systematic Review and Meta-Analysis. 62
35817335 2022
24
Gastroschisis for the Gastroenterologist: Updates on Epidemiology, Management, and Outcomes. 62
35727685 2022
25
Comparison of three risk stratification scores in gastroschisis neonates: gastroschisis prognostic score, gastroschisis risk stratification index and complex gastroschisis. 62
35881242 2022
26
Gastroschisis prognostic score successfully identifies Brazilian newborns with high-risk gastroschisis. 62
35321798 2022
27
Perinatal management of pregnancies with Fetal Congenital Anomalies: A guide to Obstetricians and Pediatricians. 62
36200158 2022
28
Early pregnancy vitamin D status and risk of select congenital anomalies in the National Birth Defects Prevention Study. 62
36203383 2022
29
Management of Abdominal Wall Defects. 62
36209747 2022
30
Operative Volume of Newborn Surgery in German University Hospitals: High Volume Versus Low Volume Centers. 62
35026856 2022
31
Surgical neonates with coronavirus infectious disease-19 infection: An experience with five cases at high-volume tertiary care centre of India. 62
36018203 2022
32
Comparative Study between Acacia Nilotica versus Povidone Iodine in Topical Treatment of Omphalocele Major. 62
36189534 2022
33
Predictors of length of stay for simple gastroschisis: analysis of ACS NSQIP-P database. 62
35876903 2022
34
Recognition and repair of an incidental umbilical hernia repair during abdominoplasty. 62
36268346 2022
35
Defining a Body Mass Index Threshold for Preventing Recurrence in Ventral Hernia Repairs. 62
35578162 2022
36
Integration and Implementation of Patient-Reported Outcomes (PRO): A Prospective, Observational Clinical Quality Improvement Study. 62
36251864 2022
37
Semiresorbable biologic hybrid meshes for ventral abdominal hernia repair in potentially contaminated settings: lower risk of recurrence. 62
36223064 2022
38
Correction to: Abdominal hernia mesh repair in patients with inflammatory bowel disease: A systematic review. 62
36190541 2022
39
Application of indocyanine green and near-infrared fluorescence imaging for the assessment of peritoneal dialysis-related complications. 62
35545201 2022
40
Lateral hernia secondary to colorectal submucosal resection repaired by robotic-assisted approach: Case report. 62
35985112 2022
41
Shifting the Goalpost in Ventral Hernia Care: 5-year Outcomes after Ventral Hernia Repair with Poly-4-hydroxybutyrate Mesh. 62
36114396 2022
42
Inflammation Self-Limiting Electrospun Fibrous Tape via Regional Immunity for Deep Soft Tissue Repair. 62
36031400 2022
43
Diagnosis and prevention of internal abdominal hernia after laparoscopic-assisted gastrectomy. 62
36123206 2022
44
Modeling Optimal Clinical Thresholds for Elective Abdominal Hernia Repair in Patients With Cirrhosis. 62
36098965 2022
45
Multifunctional hydrogel based on dopamine-modified hyaluronic acid, gelatin and silver nanoparticles for promoting abdominal wall defect repair. 62
36100003 2022
46
A Neonatal Abdominal Wall Defect. 62
36047757 2022
47
Quantitative assessment of coat-hanger ribs detected on three-dimensional ultrasound for prenatal diagnosis of Kagami-Ogata syndrome. 62
36087043 2022
48
Reconstruction of lower abdominal wall defect caused by giant dermatofibrosarcoma protuberans: A case report. 62
36127199 2022
49
Prenatal diagnosis of rare cloacal exstrophy: A case report. 62
36147113 2022
50
Surgical approach and etiopathogenetic considerations to the umbilical tumefactions in cattle: Case review in twenty years (2000/2020). 62
35784586 2022

Variations for Gastroschisis

Expression for Gastroschisis

Search GEO for disease gene expression data for Gastroschisis.

Pathways for Gastroschisis

Pathways related to Gastroschisis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 NOS3 MPO MMP8 MMP3 MMP1 IL6
2
Show member pathways
13.48 NOS3 MMP3 MMP1 IL6 IL1B F2
3
Show member pathways
12.62 MMP8 MMP3 MMP1 F5 F2 BMP1
4
Show member pathways
12.57 MMP8 MMP3 MMP1 ICAM1 BMP1
5
Show member pathways
12.42 F2 IL1B IL6 MPO NOS3
6
Show member pathways
12.13 CST3 F2 F5 IL6 MMP1
7 11.69 MMP3 MMP1 IL6 IL1B ICAM1
8 11.62 MMP1 IL6 ICAM1
9 11.55 NPPA MMP1 IL6
10 11.36 IL6 IL1B ICAM1
11 11.23 MMP1 IL6 IL1B ICAM1 ACHE
12 11.2 NOS3 MMP1 IL6
13 11.12 CYP1A2 CYP1A1 ACHE
14 10.96 IL1B ICAM1 F2
15 10.93 MMP3 MMP1 IL6 IL1B
16
Show member pathways
10.82 MMP3 MMP1 IL6 IL1B ICAM1
17 10.7 CYP1A2 CYP1A1
18 10.7 MPO IL1B ICAM1
19 10.65 IL6 IL1B
20
Show member pathways
10.5 MPO CYP1A2

GO Terms for Gastroschisis

Cellular components related to Gastroschisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.09 ACHE AEBP1 BMP1 BMP6 CST3 F2
2 extracellular space GO:0005615 9.77 ACHE AEBP1 BMP1 BMP6 CST3 F2

Biological processes related to Gastroschisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 10.03 NOS3 MPO IL1B CYP1A1
2 extracellular matrix disassembly GO:0022617 9.88 MMP8 MMP3 MMP1
3 collagen catabolic process GO:0030574 9.8 MMP1 MMP3 MMP8
4 vascular endothelial growth factor production GO:0010573 9.76 IL6 IL1B
5 porphyrin-containing compound metabolic process GO:0006778 9.67 CYP1A2 CYP1A1
6 regulation of microglial cell activation GO:1903978 9.56 MMP8 IL6
7 regulation of neuroinflammatory response GO:0150077 9.43 MMP8 MMP3 IL6
8 dibenzo-p-dioxin metabolic process GO:0018894 9.33 CYP1A2 CYP1A1
9 positive regulation of neuroinflammatory response GO:0150078 9.1 MMP8 IL6 IL1B

Molecular functions related to Gastroschisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.97 NOS3 MPO CYP1A2 CYP1A1
2 metalloendopeptidase activity GO:0004222 9.76 BMP1 MMP1 MMP3 MMP8
3 hydroperoxy icosatetraenoate dehydratase activity GO:0106256 9.71 CYP1A2 CYP1A1
4 demethylase activity GO:0032451 9.62 CYP1A2 CYP1A1
5 estrogen 2-hydroxylase activity GO:0101021 9.56 CYP1A2 CYP1A1
6 metallopeptidase activity GO:0008237 9.43 MMP8 MMP3 MMP1 BMP1
7 serine-type endopeptidase activity GO:0004252 9.32 MMP8 MMP3 MMP1 F2 BMP1

Sources for Gastroschisis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....