MCID: GST009
MIFTS: 54

Gastroschisis

Categories: Rare diseases, Gastrointestinal diseases, Fetal diseases

Aliases & Classifications for Gastroschisis

MalaCards integrated aliases for Gastroschisis:

Name: Gastroschisis 57 12 53 59 55 44 15 73
Laparoschisis 53 59
Congenital Fissure of the Abdominal Cavity 53

Characteristics:

Orphanet epidemiological data:

59
gastroschisis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe),1-5/10000 (Austria),1-5/10000 (Belgium),1-5/10000 (Croatia),1-5/10000 (Denmark),1-5/10000 (France),1-5/10000 (Germany),1-9/100000 (Hungary),1-5/10000 (Ireland),1-9/100000 (Italy),1-5/10000 (Malta),1-5/10000 (Netherlands),1-5/10000 (Norway),1-5/10000 (Poland),1-5/10000 (Portugal),1-9/100000 (Spain),1-5/10000 (Switzerland),1-5/10000 (United Kingdom),1-9/100000 (Ukraine); Age of onset: Antenatal,Neonatal; Age of death: normal life expectancy;

OMIM:

57
Inheritance:
autosomal recessive vs. multifactorial


Classifications:



External Ids:

OMIM 57 230750
Disease Ontology 12 DOID:11044
ICD10 33 Q79.3
ICD9CM 35 756.73
MeSH 44 D020139
NCIt 50 C84725
SNOMED-CT 68 72951007
Orphanet 59 ORPHA2368
MESH via Orphanet 45 D020139
UMLS via Orphanet 74 C0265706
ICD10 via Orphanet 34 Q79.3
MedGen 42 C0265706
UMLS 73 C0265706

Summaries for Gastroschisis

NIH Rare Diseases : 53 Gastroschisis is a birth defect that occurs when a baby's intestines extend outside of the body through a hole next to the belly button. This type of defect is known as an abdominal wall defect. Sometimes other organs are also involved.   The exact cause of a gastroschisis is usually not known, but it is more common in babies born to young mothers or to mothers who may have used alcohol or tobacco during their pregnancies. Gastroschisis is typically diagnosed on routine ultrasound examinations before a baby is born. These babies may need to be born in hospitals with specialists who are experienced in treating gastroschisis. Treatment includes a special kind of surgery that gradually returns the intestines to the abdomen (silo repair).Prognosis depends primarily on the degree of injury to the bowel, and on the presence of other birth defects. Though long-term outcomes for babies born with simple gastroschisis are generally good, some children may have problems with digestion later in life. Complications from gastroschisis can include intestinal problems, breathing difficulties, and infection. Some cases of gastroschisis may resolve in utero, with closure of the hole of the abdominal wall, resulting in strangulation and destruction of the herniated bowel (vanishing gastroschisis or vanishing gut syndrome), and very short-bowel syndrome. Other complications include incomplete bowel (atresia), destruction (necrosis), perforation or twisting (volvulos). The prognosis of these cases is poor, but detecting these problems during pregnancy (antenatal diagnosis) and having fetal intervention may improve the outcome in the future.

MalaCards based summary : Gastroschisis, also known as laparoschisis, is related to omphalocele and placenta disease. An important gene associated with Gastroschisis is AEBP1 (AE Binding Protein 1), and among its related pathways/superpathways are Phospholipase-C Pathway and p70S6K Signaling. The drugs Glycerol and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include liver, colon and small intestine, and related phenotypes are gastroschisis and intestinal atresia

OMIM : 57 Gastroschisis is a congenital defect of the abdominal wall that occurs laterally to, and often to the right of, a normally closed umbilical ring. Visceral organs that herniate through the defect are not covered by a membrane. Gastroschisis is distinct from omphalocele (164750), which is characterized by herniation of abdominal contents through the base of the umbilical cord; in omphalocele, the visceral organs are covered by membranes (summary by Mastroiacovo et al., 2007). Both omphalocele and gastroschisis, when they occur without other malformations, are probably multifactorial (Baird and MacDonald, 1981). (230750)

Wikipedia : 76 Gastroschisis is a birth defect in which the baby\'s intestines extend outside of the body through a... more...

Related Diseases for Gastroschisis

Diseases related to Gastroschisis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 omphalocele 30.6 AFP BMP1
2 placenta disease 29.8 AFP IL6 MTHFR
3 orofacial cleft 29.4 MTHFR NAT2 TGFB3
4 mucositis 29.2 MTHFR TGFB3
5 anencephaly 28.6 ACHE AFP MTHFR
6 neural tube defects 28.0 ACHE AFP MTHFR NAT2
7 abdominal wall defect 11.9
8 omphalocele, autosomal 11.1
9 paraomphalocele 10.9
10 osteoporotic fracture 10.5 IL6 MTHFR
11 sudden sensorineural hearing loss 10.5 IL6 MTHFR
12 encephalomalacia 10.5 IL6 MTHFR
13 central retinal vein occlusion 10.5 IL6 MTHFR
14 hematopoietic stem cell transplantation 10.4 IL6 MTHFR
15 testicular infarct 10.4 AFP MTHFR
16 portal vein thrombosis 10.3 AFP MTHFR
17 hepatic vascular disease 10.2 AFP MTHFR
18 aging 10.2
19 intestinal atresia 10.2
20 retinal vein occlusion 10.2 IL6 MTHFR
21 vein disease 10.2 AFP MTHFR
22 reproductive organ benign neoplasm 10.1 AFP TGFB3
23 tuberculoid leprosy 10.1 BMP6 TGFB3
24 hypertrophic scars 10.0 BMP6 TGFB3
25 diaphragmatic hernia, congenital 10.0
26 short bowel syndrome 10.0
27 fasciitis 10.0 BMP6 IL6
28 uterine anomalies 9.9 AFP IL6 MTHFR
29 juvenile nasopharyngeal angiofibroma 9.9 BMP6 TGFB3
30 ascites, chylous 9.9
31 rasmussen encephalitis 9.9 BMP6 IL6
32 telangiectasis 9.9 AFP BMP6
33 septooptic dysplasia 9.8
34 jejunal atresia 9.8
35 colonic atresia 9.8
36 body mass index quantitative trait locus 1 9.8
37 chlamydia 9.8
38 esophagitis 9.8
39 oligohydramnios 9.8
40 prune belly syndrome 9.8
41 enterocolitis 9.8
42 neural tube defects, folate-sensitive 9.8
43 craniosynostosis 9.8
44 cloacal exstrophy 9.8
45 gastric dilatation 9.8
46 ischemia 9.8
47 neuronitis 9.8
48 perinatal necrotizing enterocolitis 9.8
49 nephrotic syndrome, type 1 9.7 ACHE AFP
50 dry eye syndrome 9.7 BMP6 IL6

Graphical network of the top 20 diseases related to Gastroschisis:



Diseases related to Gastroschisis

Symptoms & Phenotypes for Gastroschisis

Symptoms via clinical synopsis from OMIM:

57
Abdomen:
gastroschisis
anterior abdominal wall defect


Clinical features from OMIM:

230750

Human phenotypes related to Gastroschisis:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 gastroschisis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001543
2 intestinal atresia 59 32 frequent (33%) Frequent (79-30%) HP:0011100
3 abnormality of the mesentery 59 Occasional (29-5%)
4 abnormality of mesentery morphology 32 occasional (7.5%) HP:0100016

GenomeRNAi Phenotypes related to Gastroschisis according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.7 ACHE
2 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.7 AEBP1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.7 BMP6
4 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.7 BMP6
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.7 MTHFR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.7 BMP6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.7 ACHE
8 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.7 AEBP1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.7 ACHE
10 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.7 BMP6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 ACHE AEBP1 BMP6 MTHFR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.7 MTHFR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.7 BMP6
14 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.7 MTHFR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.7 MTHFR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.7 AEBP1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.7 AEBP1 BMP6 MTHFR
18 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.7 ACHE
19 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.7 AEBP1

MGI Mouse Phenotypes related to Gastroschisis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.86 ACHE ADD1 AEBP1 BMP1 BMP6 IL6
2 homeostasis/metabolism MP:0005376 9.81 ADD1 AEBP1 AFP BMP1 IL6 MTHFR
3 mortality/aging MP:0010768 9.56 MTHFR TGFB3 ACHE ADD1 AEBP1 AFP
4 reproductive system MP:0005389 9.1 ACHE AFP BMP6 IL6 MTHFR NAT2

Drugs & Therapeutics for Gastroschisis

Drugs for Gastroschisis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycerol Approved, Investigational Phase 4 56-81-5 753
2 Pharmaceutical Solutions Phase 4,Not Applicable
3 Protective Agents Phase 4
4
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
5
Metoclopramide Approved, Investigational Phase 3 364-62-5 4168
6 Antiemetics Phase 3
7 Autonomic Agents Phase 3
8 Dopamine Agents Phase 3
9 Dopamine Antagonists Phase 3
10 Dopamine D2 Receptor Antagonists Phase 3
11 Gastrointestinal Agents Phase 3,Phase 1,Phase 2
12 Neurotransmitter Agents Phase 3
13 Peripheral Nervous System Agents Phase 3
14
Bilirubin Phase 2, Phase 3 635-65-4 5280352
15 Fat Emulsions, Intravenous Phase 2, Phase 3
16 Liver Extracts Phase 2, Phase 3
17 Omega 3 Fatty Acid Nutraceutical Phase 2, Phase 3
18 glucagon Phase 1, Phase 2
19 Glucagon-Like Peptide 1 Phase 1, Phase 2
20 Hormone Antagonists Phase 1, Phase 2
21 Hormones Phase 1, Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
23 Incretins Phase 1, Phase 2
24 Anti-Bacterial Agents
25 Antibiotics, Antitubercular
26 Micronutrients Not Applicable
27 Trace Elements Not Applicable
28 Vitamins Not Applicable
29 Dialysis Solutions Early Phase 1
30 Anesthetics Not Applicable
31 Bifidobacterium Nutraceutical Not Applicable
32 lysine Nutraceutical Not Applicable

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Multi-Center Study To Examine The Use Of Flex HD® And Strattice In The Repair Of Large Abdominal Wall Hernias Unknown status NCT01987700 Phase 4
2 Usefulness of a Prothetic Absorbable Mesh in Incisional Hernia Prevention After Midline Laparotomy Unknown status NCT02208557 Phase 4
3 Evaluation of Glycerin Suppositories to Improve Bowel Function in Gastroschisis Recruiting NCT03355326 Phase 4 Glycerin Suppository
4 Prophylaxis of Ileostomy Closure Site Hernia by Placing Mesh Recruiting NCT02226887 Phase 4
5 The Use of Gastrografin to Help Alleviate Bowel Obstruction in Gastroschisis Patients. Not yet recruiting NCT03334578 Phase 4 Gastrografin
6 Trial of AMNIOECHANGE in Gastroschisis Affected Foetuses Unknown status NCT00127946 Phase 3
7 Metoclopramide Pilot Trial Recruiting NCT02098915 Phase 3 intravenous metoclopramide
8 Compassionate Use of Omegaven in Children Recruiting NCT02370251 Phase 2, Phase 3 Omegaven
9 Evaluating the Use of a Silastic Spring-Loaded Silo for Infants With Gastroschisis Completed NCT00539292 Phase 2
10 Safety and Dosing Study of Glucagon-like Peptide 2 (GLP-2) in Infants and Children With Intestinal Failure Terminated NCT01573286 Phase 1, Phase 2 Glucagon-Like Peptide 2;Glucagon like peptide-2
11 Music Therapy: An Adjunct To Gastroschisis Infants' Care Unknown status NCT01469208
12 Probiotics in Infants With Gastroschisis Unknown status NCT01316510 Not Applicable
13 Elemental Formula in Neonates Post Small Bowel Resection: Improved Weaning From Total Parenteral Nutrition? Unknown status NCT01891279 Not Applicable
14 Clinical and Biological Outcomes of Human Milk and Formula Intake After Gastroschisis Repair Completed NCT02575846 Not Applicable
15 Children's Surgery in Sub-Saharan Africa Completed NCT03185637
16 ProLOVE - Prospective Randomized Study of Midline Incisional Hernia Treatment Completed NCT00472537
17 PREMAPIV : Intravesical Pressure Variation at Different Bladder Instillation Volumes in Newborn Children Completed NCT01296724 Not Applicable
18 Determination of Lysine Requirement in the Parenterally Fed Neonate Completed NCT00779753 Not Applicable
19 Silo Versus Primary Closure for Gastroschisis Recruiting NCT01506531 Not Applicable
20 Oral Care in Infants With Gastroschisis Recruiting NCT03393832 Not Applicable
21 Direct Peritoneal Resuscitation in Gastroschisis Recruiting NCT03205553 Early Phase 1 Investigational Treatment Group
22 Gastroschisis Outcomes of Delivery (GOOD) Study Recruiting NCT02774746 Not Applicable
23 Utility of a Supraaponeurotic Mesh as Prophylaxis of the Midline Eventration After an Oncological Colorrectal Resection Recruiting NCT03520465 Not Applicable
24 Genetic Analysis of Congenital Diaphragmatic Disorders Recruiting NCT01243229
25 Sham Feeding Post-operative Infants Recruiting NCT03350022 Not Applicable
26 Interest of the Manual Exploration as a Supplement to the Coelioscopy in the Evaluation of the Resectability of Peritoneal Carcinosis Recruiting NCT02493972 Not Applicable
27 Impact of Life Events and Psychological Stress in Rheumatoid Arthritis Set-up : Case-control Study Within a Multifactorial and Integrative Psychological Model Recruiting NCT03550833
28 Regional Blood Saturation Levels in Gastroschisis Active, not recruiting NCT03533439
29 Primary Fascial Closure With Laparoscopic Ventral Hernia Repair: A Randomized Controlled Trial Active, not recruiting NCT02363790 Not Applicable
30 Impact of the Systematic Closure of the Epigastric Trocar on Postoperative Incisional Hernia After Sleeve Gastrectomy Rate of First Intention. Monocentric Study, Before / After Prospective. Not yet recruiting NCT02973009
31 Mini-laparotomy Versus Mini Lumbotomy Not yet recruiting NCT02888613 Not Applicable
32 Sutureless vs Sutured Gastroschisis Closure Terminated NCT01094587 Not Applicable
33 Randomized Clinical Trial of Early Delivery in Fetal Gastroschisis vs. Routine Care Terminated NCT01884324 Not Applicable
34 Bedside Silo Versus Operative Closure for Gastroschisis Terminated NCT00404690 Not Applicable
35 Prevention of Parenteral Nutrition-Associated Cholestasis With Cyclic Parenteral Nutrition in Infants Terminated NCT01062815 Not Applicable

Search NIH Clinical Center for Gastroschisis

Cochrane evidence based reviews: gastroschisis

Genetic Tests for Gastroschisis

Anatomical Context for Gastroschisis

MalaCards organs/tissues related to Gastroschisis:

41
Liver, Colon, Small Intestine, Heart, Skin, Testis, Smooth Muscle

Publications for Gastroschisis

Articles related to Gastroschisis:

(show top 50) (show all 829)
# Title Authors Year
1
Clinical features and practice patterns of gastroschisis: a retrospective analysis using a Japanese national inpatient database. ( 29770842 )
2018
2
Stomach herniation prior to nonreassuring fetal status in a case of fetal gastroschisis. ( 29797442 )
2018
3
The Management of an Ectopic Ovary in an Adolescent Patient with Gastroschisis. ( 29730430 )
2018
4
Gastroschisis and Cumulative Stressor Exposures. ( 29863532 )
2018
5
Mode of delivery in pregnancies with gastroschisis according to delivery institution. ( 29562799 )
2018
6
Complex gastroschisis: Clinical spectrum and neonatal outcomes at a referral center. ( 29628208 )
2018
7
Low serum fatty acid levels in pregnancies with fetal gastroschisis: A prospective study. ( 29575623 )
2018
8
Prevalence, Mortality, and Spatial Distribution of Gastroschisis in Mexico. ( 29317257 )
2018
9
Familial occurrence of gastroschisis: a population-based overview on recurrence risk, sex-dependent influence, and geographical distribution. ( 29335896 )
2018
10
Complexity of gastroschisis predicts outcome: epidemiology and experience in an Australian tertiary centre. ( 29890949 )
2018
11
The influence of gestational age, mode of delivery and abdominal wall closure method on the surgical outcome of neonates with uncomplicated gastroschisis. ( 29417204 )
2018
12
The glucagon like peptide-2 'axis': Capacity for production and response following intestinal resection or repair of gastroschisis in infants. ( 29523359 )
2018
13
Use of a Gastroschisis Feeding Guideline to Improve Standardization of Care and Patient Outcomes at an Urban Children's Hospital. ( 29617042 )
2018
14
A Giant Gastroschisis Associated with Pulmonary Hypoplasia and Spinal Anomaly: A Case Report and a Literature Review. ( 29854529 )
2018
15
Meconium-stained amniotic fluid as a predictor of poor outcomes in gastroschisis. ( 29803305 )
2018
16
Herpesvirus Infection in Infants with Gastroschisis. ( 29634591 )
2018
17
Coincident myelomeningocele and gastroschisis: report of 2 cases. ( 29521606 )
2018
18
Understanding gastroschisis and its clinical management: where are we? ( 29419329 )
2018
19
Maternal administration of cannabidiol promotes an anti-inflammatory effect on the intestinal wall in a gastroschisis rat model. ( 29561958 )
2018
20
National Practice Patterns for Prenatal Monitoring in Gastroschisis: Gastroschisis Outcomes of Delivery (GOOD) Provider Survey. ( 29791899 )
2018
21
Nutrition Delivery and Growth Outcomes in Infants With Gastroschisis. ( 29338079 )
2018
22
Development of a gastroschisis core outcome set. ( 29540463 )
2018
23
Genetic variants conferring susceptibility to gastroschisis: a phenomenon restricted to the interaction with the environment? ( 29550988 )
2018
24
Predicting birth weight in fetuses with gastroschisis. ( 29266095 )
2018
25
Early Life Incidence of Gastrointestinal and Respiratory Infections in Children with Gastroschisis: A Cohort Study. ( 29851769 )
2018
26
The factors associated with successful early enteral feeding in gastroschisis. ( 29802444 )
2018
27
An evaluation of nutritional and vasoactive stimulants as risk factors for gastroschisis: a pilot study. ( 29415587 )
2018
28
Vanishing gastroschisis visualized by antenatal ultrasound: a case report and review of literature. ( 29980113 )
2018
29
Closed gastroschisis with left defect: a rare variant. ( 29367227 )
2018
30
Fetal growth standards in gastroschisis: Reference values for ultrasound measurements. ( 29110317 )
2017
31
Infectious outcomes of gastroschisis patients with intraoperative hypothermia. ( 28688668 )
2017
32
Omphalocele and Gastroschisis in Newborns: Over 16 Years of Experience from a Single Clinic. ( 28770124 )
2017
33
Contemporary Outcomes of Infants with Gastroschisis in North America: A Multicenter Cohort Study. ( 28712519 )
2017
34
Maternal Stressors and Social Support and Risks of Delivering Babies With Gastroschisis or Hypospadias. ( 28505275 )
2017
35
Outcome of neonates with gastroschisis at different gestational ages using a national database. ( 28780310 )
2017
36
Clinicoplacental correlates of amniocyte vacuolization in association with gastroschisis. ( 28864023 )
2017
37
The Effect of Level of Care on Gastroschisis Outcomes. ( 29144275 )
2017
38
Transamniotic stem cell therapy (TRASCET) in a leporine model of gastroschisis. ( 27836365 )
2017
39
Re-Tubularization of Highly-Ischemic Anti-Mesenteric Border (ReHAB): A Novel Bowel Preservation Technique in Complex Gastroschisis. ( 28920023 )
2017
40
Left Sided Gastroschisis. ( 28770150 )
2017
41
Possible etiologies of increased incidence of gastroschisis. ( 28952022 )
2017
42
The significance of organ prolapse in gastroschisis. ( 28951014 )
2017
43
Use of quality improvement (QI) methodology to decrease length of stay (LOS) for newborns with uncomplicated gastroschisis. ( 29291893 )
2017
44
Evaluation of Early Onset Sepsis, Complete Blood Count, and Antibiotic Use in Gastroschisis. ( 29084414 )
2017
45
Prenatal markers and longitudinal follow-up in simple and complex gastroschisis. ( 28615305 )
2017
46
Maternal Chlamydia infection during pregnancy among younger mothers and risk of gastroschisis in singleton offspring. ( 29193865 )
2017
47
Outcomes of gastroschisis early delivery: A systematic review and meta-analysis. ( 28947324 )
2017
48
The use of ECMO for gastroschisis and omphalocele: Two decades of experience. ( 28410786 )
2017
49
Understanding the relationship between hospital volume and patient outcomes for infants with gastroschisis. ( 28947327 )
2017
50
Chylous Ascites in a Newborn with Gastroschisis. Case Report. ( 28083502 )
2017

Variations for Gastroschisis

Expression for Gastroschisis

Search GEO for disease gene expression data for Gastroschisis.

Pathways for Gastroschisis

Pathways related to Gastroschisis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 BMP1 BMP6 IL6 TGFB3
2
Show member pathways
12.59 BMP1 BMP6 IL6 TGFB3
3
Show member pathways
11.87 BMP1 BMP6 IL6 TGFB3
4 11.76 AFP BMP6 TGFB3
5 11.52 BMP1 BMP6 TGFB3
6 11.52 AFP BMP6 TGFB3
7 11.24 ACHE IL6
8 11.17 IL6 TGFB3
9 11.11 IL6 TGFB3
10
Show member pathways
10.94 BMP1 BMP6 IL6 TGFB3
11 10.86 IL6 MTHFR

GO Terms for Gastroschisis

Cellular components related to Gastroschisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ACHE AEBP1 AFP BMP1 BMP6 IL6
2 extracellular space GO:0005615 9.17 ACHE AEBP1 AFP BMP1 BMP6 IL6

Biological processes related to Gastroschisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.56 BMP1 BMP6 IL6 TGFB3
2 skeletal system development GO:0001501 9.5 AEBP1 BMP1 BMP6
3 positive regulation of osteoblast differentiation GO:0045669 9.43 BMP6 IL6
4 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.4 BMP6 TGFB3
5 positive regulation of bone mineralization GO:0030501 9.37 BMP6 TGFB3
6 positive regulation of SMAD protein signal transduction GO:0060391 9.16 BMP6 TGFB3
7 SMAD protein signal transduction GO:0060395 9.13 AFP BMP6 TGFB3
8 positive regulation of protein secretion GO:0050714 8.8 ACHE BMP6 TGFB3

Molecular functions related to Gastroschisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 9.26 BMP6 TGFB3
2 cytokine activity GO:0005125 9.26 BMP1 BMP6 IL6 TGFB3
3 BMP receptor binding GO:0070700 9.16 BMP6 TGFB3
4 growth factor activity GO:0008083 8.92 BMP1 BMP6 IL6 TGFB3

Sources for Gastroschisis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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