MCID: GMS001
MIFTS: 32

Gemistocytic Astrocytoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Gemistocytic Astrocytoma

MalaCards integrated aliases for Gemistocytic Astrocytoma:

Name: Gemistocytic Astrocytoma 12 58 54 15 71
Gemistocytic Astrocytic Tumor 12

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7005
MeSH 44 D001254
NCIt 50 C4321
SNOMED-CT 67 73982001
ICD10 via Orphanet 33 C71.9
UMLS via Orphanet 72 C0334581
Orphanet 58 ORPHA251604
UMLS 71 C0334581

Summaries for Gemistocytic Astrocytoma

MalaCards based summary : Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to diffuse astrocytoma and glioma susceptibility 1, and has symptoms including seizures, headache and motor manifestations. An important gene associated with Gemistocytic Astrocytoma is LINC01089 (Long Intergenic Non-Protein Coding RNA 1089), and among its related pathways/superpathways are Pathways Affected in Adenoid Cystic Carcinoma and Central carbon metabolism in cancer. Affiliated tissues include brain, eye and spinal cord.

Related Diseases for Gemistocytic Astrocytoma

Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 diffuse astrocytoma 31.2 TP53 IDH2 IDH1 GFAP ATRX
2 glioma susceptibility 1 30.3 TP53 IDH2 IDH1 CCDC26
3 hydrocephalus 29.9 TP53 S100B PTEN GFAP
4 meningioma, familial 29.8 TP53 S100B PTEN GFAP
5 malignant astrocytoma 29.8 TP53 S100B PTEN IDH2 IDH1 GFAP
6 glioblastoma 29.6 TP53 PTEN IDH2 IDH1 GFAP
7 giant cell glioblastoma 29.2 TP53 PTEN IDH2 IDH1 GFAP ATRX
8 anaplastic astrocytoma 29.2 TP53 PTEN IDH2 IDH1 GFAP ATRX
9 oligodendroglioma 28.9 TP53 S100B PTEN IDH2 IDH1 GFAP
10 oligoastrocytoma 10.3 IDH2 GFAP
11 intracranial cysts 10.3 S100B GFAP
12 hydromyelia 10.3 S100B PTEN
13 enchondroma 10.3 IDH2 IDH1
14 papillary ependymoma 10.3 S100B GFAP
15 pineocytoma 10.3 S100B GFAP
16 cutaneous leiomyosarcoma 10.3 S100B GFAP
17 adult brain stem glioma 10.3 IDH2 IDH1
18 syringocystadenoma papilliferum 10.3 S100B GFAP
19 gangliocytoma 10.3 PTEN GFAP
20 cytogenetically normal acute myeloid leukemia 10.3 IDH2 IDH1
21 chordoid meningioma 10.3 S100B GFAP
22 extraventricular neurocytoma 10.3 IDH1 GFAP
23 intracranial chondrosarcoma 10.3 IDH2 IDH1
24 traumatic brain injury 10.3 S100B GFAP
25 brain injury 10.3 S100B GFAP
26 periosteal chondrosarcoma 10.2 IDH2 IDH1
27 adult oligodendroglioma 10.2 IDH2 IDH1
28 optic nerve glioma 10.2 S100B GFAP
29 juxtacortical chondroma 10.2 IDH2 IDH1
30 spindle cell rhabdomyosarcoma 10.2 S100B GFAP
31 clear cell meningioma 10.2 S100B GFAP
32 frontal convexity meningioma 10.2 IDH1 GFAP
33 urethra transitional cell carcinoma 10.2 TP53 GFAP
34 chondroblastic osteosarcoma 10.2 IDH2 IDH1
35 syringoma 10.2 S100B GFAP
36 low grade glioma 10.2 IDH2 IDH1
37 cellular ependymoma 10.2 S100B GFAP
38 myxopapillary ependymoma 10.2 S100B GFAP
39 cerebrovascular benign neoplasm 10.2 TP53 GFAP
40 spindle cell hemangioma 10.2 IDH2 IDH1
41 spinal cancer 10.2 IDH1 GFAP
42 central nervous system primitive neuroectodermal neoplasm 10.2 TP53 GFAP
43 synchronous bilateral breast carcinoma 10.2 TP53 PTEN
44 endometrioid ovary carcinoma 10.2 TP53 PTEN
45 embryonal sarcoma 10.2 TP53 S100B
46 perineurioma 10.2 S100B GFAP
47 large intestine adenocarcinoma 10.2 TP53 PTEN
48 frontal lobe neoplasm 10.2 TP53 IDH1
49 spiradenoma 10.2 TP53 S100B
50 laryngeal neuroendocrine tumor 10.2 TP53 IDH1

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to Gemistocytic Astrocytoma

Symptoms & Phenotypes for Gemistocytic Astrocytoma

UMLS symptoms related to Gemistocytic Astrocytoma:


seizures, headache, motor manifestations, sensory manifestations

Drugs & Therapeutics for Gemistocytic Astrocytoma

Search Clinical Trials , NIH Clinical Center for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

Anatomical Context for Gemistocytic Astrocytoma

MalaCards organs/tissues related to Gemistocytic Astrocytoma:

40
Brain, Eye, Spinal Cord, Thyroid, Testis, Hypothalamus

Publications for Gemistocytic Astrocytoma

Articles related to Gemistocytic Astrocytoma:

(show top 50) (show all 75)
# Title Authors PMID Year
1
p53 and PTEN gene mutations in gemistocytic astrocytomas. 61 54
9650746 1998
2
Immunohistochemical study on the distribution of alpha and beta subunits of S-100 protein in brain tumors. 54 61
1882640 1991
3
Low-Grade Gemistocytic Morphology in H3 G34R-Mutant Gliomas and Concurrent K27M Mutation: Clinicopathologic Findings. 61
32954438 2020
4
Risk Stratification in Low Grade Glioma: A Single Institutional Experience. 61
32859817 2020
5
Diagnosis and clinical outcome following surgical resection of an intracranial grade III anaplastic gemistocytic astrocytoma in a cat. 61
32782816 2020
6
Relapsing Tumefactive Demyelination: A Case Report. 61
30585071 2018
7
Paradoxical results obtained with Ki67-labeling and PHH3-mitosis index in glial tumors: a literature analysis. 61
28853695 2017
8
Synchronous gemistocytic astrocytoma IDH-mutant and oligodendroglioma IDH-mutant and 1p/19q-codeleted in a patient with CCDC26 polymorphism. 61
28550371 2017
9
[Ultrastructural characteristics of gap junctions in human glial brain tumors]. 61
28295002 2017
10
Magnetic resonance imaging features of gemistocytic astrocytoma. 61
27766769 2016
11
Versatile utilization of real-time intraoperative contrast-enhanced ultrasound in cranial neurosurgery: technical note and retrospective case series. 61
26926064 2016
12
Intraoperative Squash Cytologic Features of Subependymal Giant Cell Astrocytoma. 61
27013816 2016
13
Alterations of the RRAS and ERCC1 genes at 19q13 in gemistocytic astrocytomas. 61
25192052 2014
14
Diagnostic pathway to amyotrophic lateral sclerosis (ALS): the significance of Babinski's sign in a unique patient and the necessity for a multidisciplinary approach. 61
23307452 2013
15
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. 61
22115534 2012
16
Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features. 61
23319187 2012
17
Long-term follow-up in adult patients with low-grade glioma (WHO II) postoperatively irradiated. Analysis of prognostic factors. 61
24377015 2012
18
First step toward the "fingerprinting" of brain tumors based on synchrotron radiation X-ray fluorescence and multiple discriminant analysis. 61
21725853 2011
19
Early prognostic factors related to progression and malignant transformation of low-grade gliomas. 61
21889256 2011
20
Discrimination between low-grade oligodendrogliomas and diffuse astrocytoma with the aid of 11C-methionine positron emission tomography. 61
21214332 2011
21
Pilocytic astrocytoma with neoplastic gemistocytes undergoing spontaneous transformation to glioblastoma multiforme without prior radiotherapy. 61
21349721 2011
22
Congenital brain tumors: diagnostic pitfalls and therapeutic interventions. 61
21464236 2011
23
Rare primary tumours of the hypothalamus in adults: clinical course and surgical treatment. 61
21225516 2010
24
Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy. 61
20197146 2010
25
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. 61
19756200 2009
26
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. 61
18987242 2008
27
Cytologic features of subependymal giant cell astrocytom: a review of 7 cases. 61
18702362 2008
28
Pediatric brain tumours at a tertiary care hospital in Karachi. 61
18159977 2007
29
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. 61
17536538 2007
30
Expression of two testis-specific genes, TSGA10 and SYCP3, in different cancers regarding to their pathological features. 61
17920210 2007
31
Congenital gemistocytic astrocytoma in a fetus. 61
15864706 2006
32
Definition and diagnostic implications of gemistocytic astrocytomas: a pathological perspective. 61
16132490 2006
33
CXCL12 expression is predictive of a shorter time to tumor progression in low-grade glioma: a single-institution study in 50 patients. 61
16132525 2005
34
Postoperative irradiation of incompletely excised gemistocytic astrocytomas. Clinical outcome and prognostic factors. 61
15827694 2005
35
Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell adhesion molecule L1 in tumour invasion. 54
15677537 2005
36
[Results of the operative treatment of intramedullary gliomas]. 61
15654672 2004
37
Astroblastoma: a case report. 61
15483362 2004
38
Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas. 61
15118874 2004
39
[A multicentric glioma presenting different pathological appearances: a case report]. 61
15287489 2004
40
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. 61
15193038 2004
41
[Diagnosis of brain gliomas in stereotactic biopsy assisted by optical neuro-navigation system]. 61
15049161 2004
42
Giant cell ependymoma of the spinal cord. Case report and review of the literature. 61
14748579 2004
43
Radiotherapy in supratentorial gliomas. A study of 821 cases. 61
14628126 2003
44
Genetic evidence of the neoplastic nature of gemistocytes in astrocytomas. 61
11699553 2001
45
Detection of a novel point mutation in the p53 gene in grade II astrocytomas by PCR-SSCP analysis with additional Klenow treatment. 61
11724349 2001
46
Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo. 61
10483780 1999
47
[Subependymal giant cell astrocytoma associated with tuberous sclerosis exhibiting rapid regrowth after 17 years: a case report]. 61
10396738 1999
48
Extracellular matrix-induced cell migration from glioblastoma biopsy specimens in vitro. 61
10090669 1999
49
[Clinical results of supratentorial astrocytoma grade II]. 61
10065446 1999
50
Modifying radical radiotherapy in high grade gliomas; shortening the treatment time through acceleration. 61
10030251 1999

Variations for Gemistocytic Astrocytoma

Expression for Gemistocytic Astrocytoma

Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for Gemistocytic Astrocytoma

Pathways related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.95 TP53 PTEN ATRX
2 10.77 TP53 PTEN IDH2 IDH1
3
Show member pathways
10.27 IDH2 IDH1

GO Terms for Gemistocytic Astrocytoma

Cellular components related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 PML body GO:0016605 8.8 TP53 PTEN ATRX

Biological processes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.58 TP53 S100B PTEN
2 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.37 TP53 PTEN
3 2-oxoglutarate metabolic process GO:0006103 9.32 IDH2 IDH1
4 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.26 TP53 ATRX
5 NADP metabolic process GO:0006739 9.16 IDH2 IDH1
6 isocitrate metabolic process GO:0006102 8.96 IDH2 IDH1
7 glyoxylate cycle GO:0006097 8.62 IDH2 IDH1

Molecular functions related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
2 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1

Sources for Gemistocytic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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