MCID: GMS001
MIFTS: 34

Gemistocytic Astrocytoma

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Gemistocytic Astrocytoma

MalaCards integrated aliases for Gemistocytic Astrocytoma:

Name: Gemistocytic Astrocytoma 12 59 55 15 73
Gemistocytic Astrocytic Tumor 12

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7005
MeSH 44 D001254
NCIt 50 C4321
SNOMED-CT 68 73982001
Orphanet 59 ORPHA251604
UMLS via Orphanet 74 C0334581
ICD10 via Orphanet 34 C71.9
UMLS 73 C0334581

Summaries for Gemistocytic Astrocytoma

MalaCards based summary : Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to fibrillary astrocytoma and giant cell glioblastoma, and has symptoms including headache, seizures and motor manifestations. An important gene associated with Gemistocytic Astrocytoma is LINC01089 (Long Intergenic Non-Protein Coding RNA 1089
The upregulation of ENST00000545440 and NR_002809 was associated with advanced clinical stages of astrocytoma.
Dysfunction Pattern: Expression), and among its related pathways/superpathways are Signaling by ERBB4 and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and spinal cord, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Gemistocytic Astrocytoma

Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 32.0 GFAP IDH2
2 giant cell glioblastoma 29.9 GFAP PTEN
3 subependymal giant cell astrocytoma 29.4 GFAP S100B
4 oligodendroglioma 29.2 GFAP IDH2 PTEN
5 astrocytoma 10.6
6 adult astrocytic tumour 10.2 IDH2 PTEN
7 oligoastrocytoma 10.1 GFAP IDH2
8 protoplasmic astrocytoma 10.1 GFAP IDH2
9 gangliocytoma 10.1 GFAP PTEN
10 anaplastic oligodendroglioma 10.1 GFAP IDH2
11 gliomatosis cerebri 10.0 GFAP PTEN
12 thyroid cancer, nonmedullary, 1 10.0
13 fibrosarcoma 10.0
14 thyroiditis 10.0
15 vasculitis 10.0
16 glioblastoma 10.0
17 hydromyelia 9.9 PTEN S100B
18 mixed type thymoma 9.8 PTEN S100B
19 intracranial cysts 9.7 GFAP S100B
20 chordoid meningioma 9.7 GFAP S100B
21 syringocystadenoma papilliferum 9.7 GFAP S100B
22 dysembryoplastic neuroepithelial tumor 9.7 GFAP S100B
23 spindle cell rhabdomyosarcoma 9.7 GFAP S100B
24 myxopapillary ependymoma 9.7 GFAP S100B
25 chordoid glioma 9.7 GFAP S100B
26 melanotic neuroectodermal tumor 9.7 GFAP S100B
27 syringoma 9.7 GFAP S100B
28 angiocentric glioma 9.7 GFAP S100B
29 pineocytoma 9.7 GFAP S100B
30 papillary ependymoma 9.7 GFAP S100B
31 perineurioma 9.7 GFAP S100B
32 papilloma of choroid plexus 9.6 GFAP S100B
33 granular cell tumor 9.6 GFAP S100B
34 traumatic brain injury 9.6 GFAP S100B
35 optic nerve glioma 9.6 GFAP S100B
36 myoepithelioma 9.6 GFAP S100B
37 brain injury 9.6 GFAP S100B
38 ganglioglioma 9.6 GFAP S100B
39 neurilemmoma 9.6 GFAP S100B
40 megalencephaly 9.6 PTEN S100B
41 atypical teratoid rhabdoid tumor 9.5 GFAP S100B
42 ependymoma 9.5 GFAP S100B
43 grade iii astrocytoma 9.5 GFAP IDH2 PTEN
44 neuroma 9.5 GFAP S100B
45 hemangioblastoma 9.5 GFAP S100B
46 brain cancer 9.4 GFAP IDH2 PTEN
47 neuronal ceroid-lipofuscinoses 9.4 GFAP S100B
48 pleomorphic adenoma 9.4 GFAP S100B
49 adenoid cystic carcinoma 9.3 PTEN S100B
50 tuberous sclerosis 9.3 GFAP S100B

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to Gemistocytic Astrocytoma

Symptoms & Phenotypes for Gemistocytic Astrocytoma

UMLS symptoms related to Gemistocytic Astrocytoma:


headache, seizures, motor manifestations, sensory manifestations

GenomeRNAi Phenotypes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.17 S100B
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.17 S100B
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.17 S100B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.17 S100B
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.17 PTEN S100B
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.17 PTEN

Drugs & Therapeutics for Gemistocytic Astrocytoma

Drugs for Gemistocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
3 Dermatologic Agents Phase 3,Phase 1
4
Histamine Phosphate Phase 3 51-74-1 65513
5 Serotonin Agents Phase 3
6 Serotonin Antagonists Phase 3
7 Gastrointestinal Agents Phase 3,Not Applicable
8 Neurotransmitter Agents Phase 3,Not Applicable
9 Histamine Antagonists Phase 3
10 Histamine H1 Antagonists Phase 3
11 Anti-Allergic Agents Phase 3
12 Antipruritics Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Crizotinib Approved Phase 1, Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
15 Protein Kinase Inhibitors Phase 1, Phase 2
16
Verteporfin Approved, Investigational Phase 1 129497-78-5
17
Trioxsalen Approved Phase 1 3902-71-4 5585
18 Dihematoporphyrin Ether Phase 1
19 Photosensitizing Agents Phase 1
20
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
21 Fluorides Not Applicable
22 Dihydroxyphenylalanine Not Applicable
23 Dopamine Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
3 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
4 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
5 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 Not Applicable 18F-fluoro-dihydroxyphenylalanine
6 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

Anatomical Context for Gemistocytic Astrocytoma

MalaCards organs/tissues related to Gemistocytic Astrocytoma:

41
Brain, Thyroid, Spinal Cord

Publications for Gemistocytic Astrocytoma

Articles related to Gemistocytic Astrocytoma:

(show all 18)
# Title Authors Year
1
Synchronous gemistocytic astrocytoma IDH-mutant and oligodendroglioma IDH-mutant and 1p/19q-codeleted in a patient with CCDC26 polymorphism. ( 28550371 )
2017
2
Magnetic resonance imaging features of gemistocytic astrocytoma. ( 27766769 )
2016
3
Alterations of the RRAS and ERCC1 genes at 19q13 in gemistocytic astrocytomas. ( 25192052 )
2014
4
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. ( 22115534 )
2012
5
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. ( 19756200 )
2009
6
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. ( 18987242 )
2008
7
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. ( 17536538 )
2007
8
Congenital gemistocytic astrocytoma in a fetus. ( 15864706 )
2006
9
Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. ( 16614946 )
2006
10
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. ( 15193038 )
2004
11
Genotype-phenotype correlation in gemistocytic astrocytomas. ( 11152345 )
2001
12
p53 and PTEN gene mutations in gemistocytic astrocytomas. ( 9650746 )
1998
13
Cystic gemistocytic astrocytoma in an adolescent. ( 29542484 )
1995
14
A gemistocytic astrocytoma demonstrated high intensity on MR images. Protein hydration layer. ( 2398944 )
1990
15
Multiple primary malignant tumours: gemistocytic astrocytoma with leptomeningeal spreading and papillary thyroid carcinoma. A case report. ( 2251958 )
1990
16
Gemistocytic astrocytoma in a one-month-old llama. ( 2365629 )
1990
17
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma. ( 626997 )
1978
18
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. ( 13301910 )
1955

Variations for Gemistocytic Astrocytoma

Expression for Gemistocytic Astrocytoma

Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for Gemistocytic Astrocytoma

Pathways related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.99 GFAP S100B
2 10.52 GFAP S100B

GO Terms for Gemistocytic Astrocytoma

Biological processes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.32 PTEN S100B
2 cellular response to hypoxia GO:0071456 9.26 PTEN S100B
3 memory GO:0007613 9.16 PTEN S100B
4 learning or memory GO:0007611 8.96 PTEN S100B
5 long-term synaptic potentiation GO:0060291 8.8 GFAP PTEN S100B

Sources for Gemistocytic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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