MCID: GMS001
MIFTS: 34

Gemistocytic Astrocytoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Gemistocytic Astrocytoma

MalaCards integrated aliases for Gemistocytic Astrocytoma:

Name: Gemistocytic Astrocytoma 11 58 28 53 14 71
Gemistocytic Astrocytic Tumor 11

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 11 DOID:7005
MeSH 43 D001254
NCIt 49 C4321
SNOMED-CT 68 73982001
ICD10 via Orphanet 32 C71.9
UMLS via Orphanet 72 C0334581
Orphanet 58 ORPHA251604
UMLS 71 C0334581

Summaries for Gemistocytic Astrocytoma

MalaCards based summary: Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to fibrillary astrocytoma and glioma susceptibility 1, and has symptoms including headache, seizures and motor manifestations. An important gene associated with Gemistocytic Astrocytoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2), and among its related pathways/superpathways are Pathways affected in adenoid cystic carcinoma and miRNA regulation of p53 pathway in prostate cancer. The drugs Dopamine and Dihydroxyphenylalanine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and spinal cord.

Related Diseases for Gemistocytic Astrocytoma

Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 31.3 TP53 IDH2 IDH1 GFAP C11orf68
2 glioma susceptibility 1 31.0 TP53 IDH2 IDH1
3 diffuse astrocytoma 30.7 TP53 PTEN MGMT IDH2 IDH1 GFAP
4 subependymal giant cell astrocytoma 30.2 S100B PTEN GFAP
5 hydrocephalus 29.9 TP53 S100B PTEN GFAP
6 brain cancer 29.4 TP53 PTEN MGMT IDH2 IDH1 GFAP
7 glioblastoma 29.2 TP53 PTEN MGMT IDH2 IDH1 GFAP
8 oligodendroglioma 28.9 TP53 S100B PTEN MGMT IDH2 IDH1
9 giant cell glioblastoma 28.8 TP53 PTEN MGMT IDH2 IDH1 GFAP
10 anaplastic astrocytoma 28.8 TP53 PTEN MGMT IDH2 IDH1 GFAP
11 meningioma, familial 28.7 TP53 S100B PTEN MGMT IDH1 GFAP
12 enchondroma 10.3 IDH2 IDH1
13 chondroma 10.3 IDH2 IDH1
14 pineocytoma 10.2 S100B GFAP
15 intracranial chondrosarcoma 10.2 IDH2 IDH1
16 anaplastic oligodendroglioma, idh-mutant and 1p/19q-codeleted 10.2 IDH2 IDH1
17 papillary ependymoma 10.2 S100B GFAP
18 periosteal chondrosarcoma 10.2 IDH2 IDH1
19 juxtacortical chondroma 10.2 IDH2 IDH1
20 sinonasal undifferentiated carcinoma 10.2 IDH2 IDH1
21 spindle cell hemangioma 10.2 IDH2 IDH1
22 d-2-hydroxyglutaric aciduria 2 10.2 IDH2 IDH1
23 syringoma 10.2 S100B GFAP
24 urethra transitional cell carcinoma 10.2 TP53 GFAP
25 myxopapillary ependymoma 10.2 S100B GFAP
26 lung oat cell carcinoma 10.2 TP53 PTEN
27 central nervous system primitive neuroectodermal neoplasm 10.2 TP53 GFAP
28 synchronous bilateral breast carcinoma 10.1 TP53 PTEN
29 endometrioid ovary carcinoma 10.1 TP53 PTEN
30 sclerosing hemangioma 10.1 TP53 PTEN
31 vaginal cancer 10.1 TP53 PTEN
32 malignant teratoma 10.1 TP53 GFAP
33 central neurocytoma 10.1 IDH1 GFAP
34 juvenile pilocytic astrocytoma 10.1 TP53 IDH1
35 sweat gland benign neoplasm 10.1 TP53 GFAP
36 lobular neoplasia 10.1 TP53 PTEN
37 nasal cavity cancer 10.1 IDH2 IDH1
38 brain stem astrocytic neoplasm 10.1 IDH1 ATRX
39 hypertrophy of breast 10.1 TP53 PTEN
40 nodular malignant melanoma 10.1 TP53 PTEN
41 pineoblastoma 10.1 TP53 GFAP
42 encephalomalacia 10.1 S100B GFAP
43 protoplasmic astrocytoma 10.1 MGMT IDH2
44 childhood astrocytic tumor 10.1 TP53 IDH1
45 female reproductive endometrioid cancer 10.1 TP53 PTEN
46 chordoid glioma 10.1 IDH2 IDH1 GFAP
47 periventricular leukomalacia 10.1 S100B GFAP
48 d-2-hydroxyglutaric aciduria 1 10.1 IDH2 IDH1 GFAP
49 skin papilloma 10.1 TP53 PTEN
50 klatskin's tumor 10.1 TP53 IDH1

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to Gemistocytic Astrocytoma

Symptoms & Phenotypes for Gemistocytic Astrocytoma

UMLS symptoms related to Gemistocytic Astrocytoma:


headache; seizures; motor manifestations; sensory manifestations

Drugs & Therapeutics for Gemistocytic Astrocytoma

Drugs for Gemistocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved 62-31-7, 51-61-6 681
2 Dihydroxyphenylalanine
3 Neurotransmitter Agents
4 Dopamine Agents
5 Fluorides

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 18F-FDOPA PET/CT or PET/MRI in Patients With Gliomas Terminated NCT02175745 18F-fluoro-dihydroxyphenylalanine
2 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

Genetic tests related to Gemistocytic Astrocytoma:

# Genetic test Affiliating Genes
1 Gemistocytic Astrocytoma 28

Anatomical Context for Gemistocytic Astrocytoma

Organs/tissues related to Gemistocytic Astrocytoma:

MalaCards : Brain, Eye, Spinal Cord, Hypothalamus, Testis, Thyroid

Publications for Gemistocytic Astrocytoma

Articles related to Gemistocytic Astrocytoma:

(show top 50) (show all 78)
# Title Authors PMID Year
1
p53 and PTEN gene mutations in gemistocytic astrocytomas. 53 62
9650746 1998
2
Immunohistochemical study on the distribution of alpha and beta subunits of S-100 protein in brain tumors. 53 62
1882640 1991
3
Germ cell tumors with neuroglial differentiation do not show molecular features akin to their central nervous system counterpart: experience from extra-gynecological sites. 62
35678876 2022
4
An Updated Comparison Between World Health Organization Grade II Gemistocytic and Diffuse Astrocytoma Survival and Treatment Patterns. 62
34844008 2022
5
Cytopathological and histopathological features of cerebral granular cell astrocytoma: A case report. 62
34608699 2022
6
Low-Grade Gemistocytic Morphology in H3 G34R-Mutant Gliomas and Concurrent K27M Mutation: Clinicopathologic Findings. 62
32954438 2020
7
Diagnosis and clinical outcome following surgical resection of an intracranial grade III anaplastic gemistocytic astrocytoma in a cat. 62
32782816 2020
8
Risk Stratification in Low Grade Glioma: A Single Institutional Experience. 62
32859817 2020
9
Relapsing Tumefactive Demyelination: A Case Report. 62
30585071 2018
10
Paradoxical results obtained with Ki67-labeling and PHH3-mitosis index in glial tumors: a literature analysis. 62
28853695 2017
11
Synchronous gemistocytic astrocytoma IDH-mutant and oligodendroglioma IDH-mutant and 1p/19q-codeleted in a patient with CCDC26 polymorphism. 62
28550371 2017
12
[Ultrastructural characteristics of gap junctions in human glial brain tumors]. 62
28295002 2017
13
Magnetic resonance imaging features of gemistocytic astrocytoma. 62
27766769 2016
14
Versatile utilization of real-time intraoperative contrast-enhanced ultrasound in cranial neurosurgery: technical note and retrospective case series. 62
26926064 2016
15
Intraoperative Squash Cytologic Features of Subependymal Giant Cell Astrocytoma. 62
27013816 2016
16
Alterations of the RRAS and ERCC1 genes at 19q13 in gemistocytic astrocytomas. 62
25192052 2014
17
Diagnostic pathway to amyotrophic lateral sclerosis (ALS): the significance of Babinski's sign in a unique patient and the necessity for a multidisciplinary approach. 62
23307452 2013
18
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. 62
22115534 2012
19
Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features. 62
23319187 2012
20
Long-term follow-up in adult patients with low-grade glioma (WHO II) postoperatively irradiated. Analysis of prognostic factors. 62
24377015 2012
21
First step toward the "fingerprinting" of brain tumors based on synchrotron radiation X-ray fluorescence and multiple discriminant analysis. 62
21725853 2011
22
Early prognostic factors related to progression and malignant transformation of low-grade gliomas. 62
21889256 2011
23
Discrimination between low-grade oligodendrogliomas and diffuse astrocytoma with the aid of 11C-methionine positron emission tomography. 62
21214332 2011
24
Pilocytic astrocytoma with neoplastic gemistocytes undergoing spontaneous transformation to glioblastoma multiforme without prior radiotherapy. 62
21349721 2011
25
Congenital brain tumors: diagnostic pitfalls and therapeutic interventions. 62
21464236 2011
26
Rare primary tumours of the hypothalamus in adults: clinical course and surgical treatment. 62
21225516 2010
27
Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy. 62
20197146 2010
28
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. 62
19756200 2009
29
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. 62
18987242 2008
30
Cytologic features of subependymal giant cell astrocytom: a review of 7 cases. 62
18702362 2008
31
Pediatric brain tumours at a tertiary care hospital in Karachi. 62
18159977 2007
32
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. 62
17536538 2007
33
Expression of two testis-specific genes, TSGA10 and SYCP3, in different cancers regarding to their pathological features. 62
17920210 2007
34
Congenital gemistocytic astrocytoma in a fetus. 62
15864706 2006
35
Definition and diagnostic implications of gemistocytic astrocytomas: a pathological perspective. 62
16132490 2006
36
CXCL12 expression is predictive of a shorter time to tumor progression in low-grade glioma: a single-institution study in 50 patients. 62
16132525 2005
37
Postoperative irradiation of incompletely excised gemistocytic astrocytomas. Clinical outcome and prognostic factors. 62
15827694 2005
38
Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell adhesion molecule L1 in tumour invasion. 53
15677537 2005
39
[Results of the operative treatment of intramedullary gliomas]. 62
15654672 2004
40
Astroblastoma: a case report. 62
15483362 2004
41
Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas. 62
15118874 2004
42
[A multicentric glioma presenting different pathological appearances: a case report]. 62
15287489 2004
43
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. 62
15193038 2004
44
Giant cell ependymoma of the spinal cord. Case report and review of the literature. 62
14748579 2004
45
[Diagnosis of brain gliomas in stereotactic biopsy assisted by optical neuro-navigation system]. 62
15049161 2004
46
Radiotherapy in supratentorial gliomas. A study of 821 cases. 62
14628126 2003
47
Genetic evidence of the neoplastic nature of gemistocytes in astrocytomas. 62
11699553 2001
48
Detection of a novel point mutation in the p53 gene in grade II astrocytomas by PCR-SSCP analysis with additional Klenow treatment. 62
11724349 2001
49
Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo. 62
10483780 1999
50
[Subependymal giant cell astrocytoma associated with tuberous sclerosis exhibiting rapid regrowth after 17 years: a case report]. 62
10396738 1999

Variations for Gemistocytic Astrocytoma

Expression for Gemistocytic Astrocytoma

Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for Gemistocytic Astrocytoma

Pathways related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.59 TP53 PTEN ATRX
2 10.46 TP53 PTEN

GO Terms for Gemistocytic Astrocytoma

Cellular components related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 PML body GO:0016605 9.1 TP53 PTEN ATRX

Biological processes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.62 TP53 ATRX
2 2-oxoglutarate metabolic process GO:0006103 9.56 IDH2 IDH1
3 NADP metabolic process GO:0006739 9.46 IDH2 IDH1
4 isocitrate metabolic process GO:0006102 9.26 IDH2 IDH1
5 glyoxylate cycle GO:0006097 8.92 IDH2 IDH1

Molecular functions related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.92 IDH2 IDH1

Sources for Gemistocytic Astrocytoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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