Gemistocytic Astrocytoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GMS001 MIFTS: 36	Gemistocytic Astrocytoma Categories: Bone diseases, Cancer diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Gemistocytic Astrocytoma

MalaCards integrated aliases for Gemistocytic Astrocytoma:

Name: Gemistocytic Astrocytoma ¹² ⁵⁸ ⁵⁴ ¹⁵ ⁷¹

Gemistocytic Astrocytic Tumor ¹²

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Neuronal diseases Bone diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Malignant neoplasms of eye, brain and other parts of central nervous system

Malignant neoplasm of brain

Malignant neoplasm: Brain, unspecified

Orphanet: ⁵⁸

Rare neurological diseases

External Ids:

Disease Ontology ¹² DOID:7005

MeSH ⁴³ D001254

NCIt ⁴⁹ C4321

SNOMED-CT ⁶⁷ 73982001

ICD10 via Orphanet ³³ C71.9

UMLS via Orphanet ⁷² C0334581

Orphanet ⁵⁸ ORPHA251604

UMLS ⁷¹ C0334581

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Summaries for Gemistocytic Astrocytoma

MalaCards based summary : Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to fibrillary astrocytoma and glial tumor, and has symptoms including seizures, headache and motor manifestations. An important gene associated with Gemistocytic Astrocytoma is LINC01089 (Long Intergenic Non-Protein Coding RNA 1089), and among its related pathways/superpathways are Glioblastoma Multiforme and Central carbon metabolism in cancer. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and bone.

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Related Diseases for Gemistocytic Astrocytoma

Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)

#	Related Disease	Score	Top Affiliating Genes
1	fibrillary astrocytoma	31.7	TP53 PTEN MGMT IDH2 IDH1 GFAP
2	glial tumor	30.7	PTEN IDH1
3	hydrocephalus	29.9	TP53 S100B PTEN GFAP
4	glioblastoma multiforme	29.4	TP53 PTEN MGMT IDH2 IDH1 GFAP
5	grade iii astrocytoma	29.3	TP53 PTEN MGMT IDH2 IDH1 GFAP
6	giant cell glioblastoma	29.0	TP53 PTEN MGMT IDH2 IDH1 GFAP
7	oligodendroglioma	28.6	TP53 S100B PTEN MGMT IDH2 IDH1
8	astrocytoma	10.9
9	intracranial cysts	10.4	S100B GFAP
10	hydromyelia	10.4	S100B PTEN
11	papillary ependymoma	10.3	S100B GFAP
12	enchondroma	10.3	IDH2 IDH1
13	pineocytoma	10.3	S100B GFAP
14	breast intraductal papillomatosis	10.3	IDH2 IDH1
15	intraductal papilloma	10.3	IDH2 IDH1
16	cutaneous leiomyosarcoma	10.3	S100B GFAP
17	syringocystadenoma papilliferum	10.3	S100B GFAP
18	breast papillomatosis	10.3	IDH2 IDH1
19	cytogenetically normal acute myeloid leukemia	10.3	IDH2 IDH1
20	extraventricular neurocytoma	10.3	IDH1 GFAP
21	chordoid meningioma	10.3	S100B GFAP
22	gangliocytoma	10.3	PTEN GFAP
23	traumatic brain injury	10.3	S100B GFAP
24	intracranial chondrosarcoma	10.3	IDH2 IDH1
25	brain injury	10.3	S100B GFAP
26	periosteal chondrosarcoma	10.3	IDH2 IDH1
27	adult oligodendroglioma	10.3	IDH2 IDH1
28	juxtacortical chondroma	10.3	IDH2 IDH1
29	interval angle-closure glaucoma	10.3	IDH2 IDH1
30	optic nerve glioma	10.3	S100B GFAP
31	clear cell meningioma	10.3	S100B GFAP
32	clear cell ependymoma	10.3	IDH1 GFAP
33	syringoma	10.3	S100B GFAP
34	intraductal breast benign neoplasm	10.3	IDH2 IDH1
35	high-grade astrocytoma	10.3	PTEN IDH1
36	urethra transitional cell carcinoma	10.3	TP53 GFAP
37	myxopapillary ependymoma	10.3	S100B GFAP
38	frontal convexity meningioma	10.2	IDH1 GFAP
39	anaplastic oligodendroglioma	10.2	MGMT IDH2
40	cerebrovascular benign neoplasm	10.2	TP53 GFAP
41	cerebellar medulloblastoma	10.2	TP53 GFAP
42	central nervous system primitive neuroectodermal neoplasm	10.2	TP53 GFAP
43	astroblastoma	10.2	IDH1 GFAP
44	endometrioid ovary carcinoma	10.2	TP53 PTEN
45	embryonal sarcoma	10.2	TP53 S100B
46	large intestine adenocarcinoma	10.2	TP53 PTEN
47	spindle cell hemangioma	10.2	IDH2 IDH1
48	thyroid cancer, nonmedullary, 1	10.2
49	fibrosarcoma	10.2
50	vestibular disease	10.2

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:

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Symptoms & Phenotypes for Gemistocytic Astrocytoma

UMLS symptoms related to Gemistocytic Astrocytoma:

seizures, headache, motor manifestations, sensory manifestations

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Drugs & Therapeutics for Gemistocytic Astrocytoma

Drugs for Gemistocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Histamine

Approved, Investigational

Phase 3

51-45-6

774

Synonyms:

1H-Imidazole-4-ethanamine

2-(1H-Imidazol-4-yl)ethanamine

2-(1H-Imidazol-4-yl)ethylamine

2-(1H-Imidazol-5-yl)ethanamine

2-(1H-Imidazol-5-yl)ethylamine

2-(4-Imidazolyl)ethanamine

2-(4-imidazolyl)ethylamine

2-(4-Imidazolyl)ethylamine

2-Imidazol-4-ylethylamine

2-Imidazol-4-yl-ethylamine

4-(2-Aminoethyl)-1H-imidazole

4-(2-Aminoethyl)imidazole

4-imidazoleethylamine

4-Imidazoleethylamine

5-imidazoleethylamine

5-Imidazoleethylamine

beta-aminoethylglyoxaline

beta-Aminoethylglyoxaline

beta-aminoethylimidazole

beta-Aminoethylimidazole

beta-Aminothethylglyoxaline

beta-Imidazolyl-4-ethylamine

b-Imidazolyl-4-ethylamine

Ceplene

Dihydrochloride, histamine

Eramin

Ergamine

Ergotidine

Free histamine

Histamine dihydrochloride

Histamine hydrochloride

HSM

Hydrochloride, histamine

L-Histamin base

L-Histamine

Peremin

Theramine

Cyproheptadine

Approved

Phase 3

129-03-3

2913

Synonyms:

129-03-3

1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine

1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine

1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine

1-Methyl-4-(5H-dibenzo(a,D)cycloheptenylidene)piperidine

4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine

4-(5-dibenzo(a,D)Cyclohepten-5-ylidine)-1-methylpiperidine

4-(5-Dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine

4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidene

4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine

4-(5H-dibenzo(a,D)Cyclohepten-5-ylidene)-1-methylpiperidine

4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine

4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine

4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine

41354-29-4

4-dibenzo[a,D]Cyclohepten-5-ylidene-1-methyl-piperidine

4-Dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidine

5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene

5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene

5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,D)cyclopheptene

5-20-08-00500 (Beilstein Handbook Reference)

AC1L1ER8

AKOS004119847

Antergan

BIDD:GT0324

Biomol-NT_000131

BPBio1_000096

BPBio1_000155

BRD-K28143534-001-01-4

BRD-K28143534-003-03-6

BRN 1685976

BSPBio_000086

C06935

CAS-969-33-5

CCRIS 5232

CHEBI:4046

CHEMBL516

CID2913

Ciproheptadina

Ciproheptadina [INN-Spanish]

Ciprovit

Ciprovit (TN)

Cypoheptadine

Cyproheptadiene

Cyproheptadin

Cyproheptadine

CYPROHEPTADINE

Cyproheptadine (INN)

Cyproheptadine [INN:BAN]

Cyproheptadine Hcl

Cyproheptadinum

Cyproheptadinum [INN-Latin]

D07765

DB00434

Dibenzosuberonone/Cyproheptadine

Dihexazin

Dronactin

EINECS 204-928-9

Eiproheptadine

HMS2090P20

HSDB 3048

L001016

Lopac0_000246

Lopac-C-6022

LS-114933

MK 141

MolPort-002-507-777

NCGC00015252-01

NCGC00015252-02

NCGC00015252-03

NCGC00015252-09

NCGC00024293-02

NCGC00024293-04

NCGC00024293-05

nchembio.559-comp10

Oprea1_498140

PDSP1_001229

PDSP2_001213

Periactin

Periactine

Periactinol

Peritol

Prestwick0_000103

Prestwick1_000103

Prestwick2_000103

Prestwick3_000103

SPBio_002025

STK802098

Tocris-0996

UNII-2YHB6175DO

Viternum

Neurotransmitter Agents

Phase 3

Histamine Antagonists

Phase 3

Anti-Allergic Agents

Phase 3

Histamine Phosphate

Phase 3

51-74-1

65513

Synonyms:

1H-Imidazole-4-ethanamine, phosphate (1:2)

2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)

4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)

4-(2-Aminoethyl)imidazole di-acid phosphate

4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate

51-74-1

53623-99-7

74-56-6

AC1L23E4

CID65513

D04445

DB00667

EINECS 200-118-4

H0147

Histamine acid phosphate

Histamine biphosphate

Histamine dihydrogen phosphate

Histamine diphosphate

Histamine phosphate (1:2)

Histamine phosphate (TN)

Histamine phosphate (USP)

Histamine phosphate [USP]

Histamine positive

LS-78569

UNII-QWB37T4WZZ

Histamine H1 Antagonists

Phase 3

Dermatologic Agents

Phase 3

Gastrointestinal Agents

Phase 3

Serotonin

Investigational, Nutraceutical

Phase 3

50-67-9

5202

Synonyms:

3-(2-Aminoethyl)-1H-indol-5-ol

3-(2-Aminoethyl)indol-5-ol

3-(b-Aminoethyl)-5-hydroxyindole

5 Hydroxytryptamine

5-HT

5-HTA

5-Hydroxy-3-(b-aminoethyl)indole

5-Hydroxyltryptamine

5-Hydroxytriptamine

5-Hydroxytryptamine

5-Hydroxy-tryptamine

Antemovis

DS Substance

Enteramin

Enteramine

Hippophaine

Hydroxytryptamine

Serotonine

sérotonine

thrombocytin

Thrombocytin

thrombotonin

Thrombotonin

Verteporfin

Approved, Investigational

Phase 1

129497-78-5

Trioxsalen

Approved

Phase 1

3902-71-4

5585

Synonyms:

2',4,8-Trimethylpsoralen

2,5,9-Trimethyl-7H-furo(3,2-g)benzopyran-7-one

4,5',8-Trimethylpsoralen

4,8,5'-Trimethylpsoralen

6-Hydroxy-b,2,7-trimethyl-5-benzofuranacrylate, delta-lactone

6-Hydroxy-b,2,7-trimethyl-5-benzofuranacrylate, δ-lactone

6-Hydroxy-b,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone

6-Hydroxy-b,2,7-trimethyl-5-benzofuranacrylic acid, δ-lactone

6-Hydroxy-beta,2,7-trimethyl-5-benzofuranacrylate, delta-lactone

6-Hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone

6-Hydroxy-β,2,7-trimethyl-5-benzofuranacrylate, δ-lactone

6-hydroxy-β,2,7-trimethyl-5-benzofuranacrylic acid, δ-lactone

6-Hydroxy-β,2,7-trimethyl-5-benzofuranacrylic acid, δ-lactone

ICN brand OF trioxsalen

Trimethylpsoralen

Trioxisaleno

Trioxisalenum

Trioxsalen

Trioxysalen

Trioxysalene

Trioxysalenum

Trisoralen

Imetelstat

Investigational

Phase 1

868169-64-6

Dihematoporphyrin Ether

Phase 1

Photosensitizing Agents

Phase 1

Protein Kinase Inhibitors

Phase 1

Motesanib diphosphate

Phase 1

850649-62-6

11450633

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk	Terminated	NCT01132547	Phase 3	cyproheptadine hydrochloride
2	Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study	Unknown status	NCT00002647	Phase 1	verteporfin
3	A Phase 1 Study of Imetelstat, a Telomerase Inhibitor, in Children With Refractory or Recurrent Solid Tumors and Lymphomas	Completed	NCT01273090	Phase 1	imetelstat sodium

Search NIH Clinical Center for Gemistocytic Astrocytoma

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Genetic Tests for Gemistocytic Astrocytoma

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Anatomical Context for Gemistocytic Astrocytoma

MalaCards organs/tissues related to Gemistocytic Astrocytoma:

⁴⁰

Brain, Eye, Bone, Spinal Cord, Thyroid, Testis, Hypothalamus

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Publications for Gemistocytic Astrocytoma

Articles related to Gemistocytic Astrocytoma:

(show top 50) (show all 72)

#	Title	Authors	PMID	Year
1	p53 and PTEN gene mutations in gemistocytic astrocytomas. ⁶¹ ⁵⁴	Watanabe K...Ohgaki H	9650746	1998
2	Immunohistochemical study on the distribution of alpha and beta subunits of S-100 protein in brain tumors. ⁶¹ ⁵⁴	Hayashi K...Akagi T	1882640	1991
3	Relapsing Tumefactive Demyelination: A Case Report. ⁶¹	Omerhodzic I...Suljic E	30585071	2018
4	Paradoxical results obtained with Ki67-labeling and PHH3-mitosis index in glial tumors: a literature analysis. ⁶¹	Elmaci I...Sav A	28853695	2017
5	Synchronous gemistocytic astrocytoma IDH-mutant and oligodendroglioma IDH-mutant and 1p/19q-codeleted in a patient with CCDC26 polymorphism. ⁶¹	Vaubel RA...Kipp BR	28550371	2017
6	[Ultrastructural characteristics of gap junctions in human glial brain tumors]. ⁶¹	Kirichenko EY...Logvinov AK	28295002	2017
7	Magnetic resonance imaging features of gemistocytic astrocytoma. ⁶¹	Simkin PM...Gaillard F	27766769	2016
8	Versatile utilization of real-time intraoperative contrast-enhanced ultrasound in cranial neurosurgery: technical note and retrospective case series. ⁶¹	Lekht I...Zada G	26926064	2016
9	Intraoperative Squash Cytologic Features of Subependymal Giant Cell Astrocytoma. ⁶¹	Nasit J...Patel S	27013816	2016
10	Alterations of the RRAS and ERCC1 genes at 19q13 in gemistocytic astrocytomas. ⁶¹	Ohta T...Ohgaki H	25192052	2014
11	Diagnostic pathway to amyotrophic lateral sclerosis (ALS): the significance of Babinski's sign in a unique patient and the necessity for a multidisciplinary approach. ⁶¹	Bulthuis V...Schijns O	23307452	2013
12	Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. ⁶¹	Godefroy A...Gerardin E	22115534	2012
13	Long-term follow-up in adult patients with low-grade glioma (WHO II) postoperatively irradiated. Analysis of prognostic factors. ⁶¹	Mucha-Malecka A...Chrostowska A	24377015	2012
14	Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features. ⁶¹	Karsy M...Arslan E	23319187	2012
15	First step toward the "fingerprinting" of brain tumors based on synchrotron radiation X-ray fluorescence and multiple discriminant analysis. ⁶¹	Szczerbowska-Boruchowska M...Adamek D	21725853	2011
16	Early prognostic factors related to progression and malignant transformation of low-grade gliomas. ⁶¹	Jung TY...Jang WY	21889256	2011
17	Discrimination between low-grade oligodendrogliomas and diffuse astrocytoma with the aid of 11C-methionine positron emission tomography. ⁶¹	Shinozaki N...Iwadate Y	21214332	2011
18	Congenital brain tumors: diagnostic pitfalls and therapeutic interventions. ⁶¹	Manoranjan B...Provias JP	21464236	2011
19	Pilocytic astrocytoma with neoplastic gemistocytes undergoing spontaneous transformation to glioblastoma multiforme without prior radiotherapy. ⁶¹	Privett BJ...Lo P	21349721	2011
20	Rare primary tumours of the hypothalamus in adults: clinical course and surgical treatment. ⁶¹	Majchrzak K...Ladzinski P	21225516	2010
21	Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy. ⁶¹	Pluhar GE...Ohlfest JR	20197146	2010
22	Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. ⁶¹	Cadir B...Turkaslan SS	19756200	2009
23	Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. ⁶¹	Aloisio F...Edwards JF	18987242	2008
24	Cytologic features of subependymal giant cell astrocytom: a review of 7 cases. ⁶¹	Takei H...Bhattacharjee MB	18702362	2008
25	Pediatric brain tumours at a tertiary care hospital in Karachi. ⁶¹	Ahmed N...Shakoor KA	18159977	2007
26	Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. ⁶¹	Kim SH...Kim TS	17536538	2007
27	Expression of two testis-specific genes, TSGA10 and SYCP3, in different cancers regarding to their pathological features. ⁶¹	Mobasheri MB...Modarressi MH	17920210	2007
28	Congenital gemistocytic astrocytoma in a fetus. ⁶¹	Nozaki M...Sawamura Y	15864706	2006
29	Definition and diagnostic implications of gemistocytic astrocytomas: a pathological perspective. ⁶¹	Tihan T...Keles GE	16132490	2006
30	CXCL12 expression is predictive of a shorter time to tumor progression in low-grade glioma: a single-institution study in 50 patients. ⁶¹	Salmaggi A...Boiardi A	16132525	2005
31	Postoperative irradiation of incompletely excised gemistocytic astrocytomas. Clinical outcome and prognostic factors. ⁶¹	Nowak-Sadzikowska J...Pluta E	15827694	2005
32	Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell adhesion molecule L1 in tumour invasion. ⁵⁴	Suzuki T...Yoshimine T	15677537	2005
33	[Results of the operative treatment of intramedullary gliomas]. ⁶¹	Maliszewski M...Majchrzak H	15654672	2004
34	Astroblastoma: a case report. ⁶¹	Kim DS...Lee SP	15483362	2004
35	Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas. ⁶¹	Okamoto Y...Ohgaki H	15118874	2004
36	[A multicentric glioma presenting different pathological appearances: a case report]. ⁶¹	Kaku S...Abe T	15287489	2004
37	November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. ⁶¹	Bleggi-Torres LF...Araujo JC	15193038	2004
38	Giant cell ependymoma of the spinal cord. Case report and review of the literature. ⁶¹	Fourney DR...Rhines LD	14748579	2004
39	[Diagnosis of brain gliomas in stereotactic biopsy assisted by optical neuro-navigation system]. ⁶¹	Nowacki P...Honczarenko K	15049161	2004
40	Radiotherapy in supratentorial gliomas. A study of 821 cases. ⁶¹	Heesters M...Go GK	14628126	2003
41	Genetic evidence of the neoplastic nature of gemistocytes in astrocytomas. ⁶¹	Reis RM...Ohgaki H	11699553	2001
42	Detection of a novel point mutation in the p53 gene in grade II astrocytomas by PCR-SSCP analysis with additional Klenow treatment. ⁶¹	Chawengchao B...Thangnipon W	11724349	2001
43	Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo. ⁶¹	Deininger MH...Meyermann R	10483780	1999
44	[Subependymal giant cell astrocytoma associated with tuberous sclerosis exhibiting rapid regrowth after 17 years: a case report]. ⁶¹	Kawasaki S...Ohtsuki Y	10396738	1999
45	Extracellular matrix-induced cell migration from glioblastoma biopsy specimens in vitro. ⁶¹	Mahesparan R...Lund-Johansen M	10090669	1999
46	[Clinical results of supratentorial astrocytoma grade II]. ⁶¹	Matsumoto K...Furuta T	10065446	1999
47	Modifying radical radiotherapy in high grade gliomas; shortening the treatment time through acceleration. ⁶¹	Brada M...Ashley S	10030251	1999
48	Clonal analysis of gliomas. ⁶¹	Kattar MM...Sarkar FH	9343324	1997
49	Proliferation of gemistocytic cells and glial fibrillary acidic protein (GFAP)-positive oligodendroglial cells in gliomas: a MIB-1/GFAP double labeling study. ⁵⁴	Kros JM...van der Kwast TH	8773153	1996
50	Meningeal rhabdomyosarcoma. Report of a case with cytologic, immunohistologic and ultrastructural studies. ⁶¹	Kobayashi S...Haba R	7762328	1995

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Genes for Gemistocytic Astrocytoma

Genes related to Gemistocytic Astrocytoma (1 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	LINC01089	Long Intergenic Non-Protein Coding RNA 1089	RNA Gene	150	Experimental evidence: Expression ³⁸	26252651
2	IDH2	Isocitrate Dehydrogenase (NADP(+)) 2	Protein Coding	29.96	Orphanet ⁵⁸ DISEASES inferred ¹⁵
3	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	14.8	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	15677537 8773153
4	PTEN	Phosphatase And Tensin Homolog	Protein Coding	11.22	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	9650746
5	S100B	S100 Calcium Binding Protein B	Protein Coding	10.45	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	1882640
6	C11orf68	Chromosome 11 Open Reading Frame 68	Protein Coding	6.88	DISEASES inferred ¹⁵
7	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	6.19	DISEASES inferred ¹⁵
8	TP53	Tumor Protein P53	Protein Coding	5.88	DISEASES inferred ¹⁵
9	TSGA10	Testis Specific 10	Protein Coding	5.81	DISEASES inferred ¹⁵
10	SYCP3	Synaptonemal Complex Protein 3	Protein Coding	5.58	DISEASES inferred ¹⁵
11	CCDC26	CCDC26 Long Non-Coding RNA	RNA Gene	5.53	DISEASES inferred ¹⁵
12	MGMT	O-6-Methylguanine-DNA Methyltransferase	Protein Coding	5.24	DISEASES inferred ¹⁵

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Variations for Gemistocytic Astrocytoma

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Expression for Gemistocytic Astrocytoma

Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

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Pathways for Gemistocytic Astrocytoma

Pathways related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Glioblastoma Multiforme ⁶³	11.18	TP53 PTEN MGMT
2	Central carbon metabolism in cancer ³⁶	10.77	TP53 PTEN IDH2 IDH1
3	Cytosine methylation ¹ Show member pathways TET1,2,3 and TDG demethylate DNA ⁶⁵	10.27	IDH2 IDH1

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GO Terms for Gemistocytic Astrocytoma

Biological processes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	central nervous system development	GO:0007417	9.63	TP53 S100B PTEN
2	cellular response to hypoxia	GO:0071456	9.54	TP53 S100B PTEN
3	response to organic cyclic compound	GO:0014070	9.5	PTEN MGMT IDH1
4	positive regulation of cardiac muscle cell apoptotic process	GO:0010666	9.43	TP53 PTEN
5	2-oxoglutarate metabolic process	GO:0006103	9.4	IDH2 IDH1
6	NADP metabolic process	GO:0006739	9.26	IDH2 IDH1
7	isocitrate metabolic process	GO:0006102	9.16	IDH2 IDH1
8	long-term synaptic potentiation	GO:0060291	9.13	S100B PTEN GFAP
9	glyoxylate cycle	GO:0006097	8.62	IDH2 IDH1

Molecular functions related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	isocitrate dehydrogenase (NADP+) activity	GO:0004450	8.96	IDH2 IDH1
2	isocitrate dehydrogenase activity	GO:0004448	8.62	IDH2 IDH1

Sources

Sources for Gemistocytic Astrocytoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia