MCID: GMS001
MIFTS: 35

Gemistocytic Astrocytoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Gemistocytic Astrocytoma

MalaCards integrated aliases for Gemistocytic Astrocytoma:

Name: Gemistocytic Astrocytoma 12 60 56 15 74
Gemistocytic Astrocytic Tumor 12

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7005
MeSH 45 D001254
NCIt 51 C4321
SNOMED-CT 69 73982001
ICD10 via Orphanet 35 C71.9
UMLS via Orphanet 75 C0334581
Orphanet 60 ORPHA251604
UMLS 74 C0334581

Summaries for Gemistocytic Astrocytoma

MalaCards based summary : Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to fibrillary astrocytoma and giant cell glioblastoma, and has symptoms including seizures, headache and motor manifestations. An important gene associated with Gemistocytic Astrocytoma is LINC01089 (Long Intergenic Non-Protein Coding RNA 1089), and among its related pathways/superpathways are Signaling by ERBB4 and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and spinal cord, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Gemistocytic Astrocytoma

Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 32.3 GFAP IDH2
2 giant cell glioblastoma 30.1 GFAP PTEN
3 subependymal giant cell astrocytoma 29.9 GFAP S100B
4 oligodendroglioma 29.1 GFAP IDH2 PTEN S100B
5 astrocytoma 10.7
6 thyroid cancer, nonmedullary, 1 10.1
7 thyroid cancer 10.1
8 fibrosarcoma 10.1
9 vasculitis 10.1
10 glioblastoma 10.1
11 adult astrocytic tumour 10.1 IDH2 PTEN
12 oligoastrocytoma 10.0 GFAP IDH2
13 protoplasmic astrocytoma 10.0 GFAP IDH2
14 anaplastic oligodendroglioma 10.0 GFAP IDH2
15 glioma susceptibility 1 10.0 GFAP IDH2
16 gliomatosis cerebri 10.0 GFAP PTEN
17 hydromyelia 9.9 PTEN S100B
18 mixed type thymoma 9.9 PTEN S100B
19 ependymoma 9.9 GFAP S100B
20 intracranial cysts 9.9 GFAP S100B
21 syringocystadenoma papilliferum 9.9 GFAP S100B
22 chordoid meningioma 9.9 GFAP S100B
23 dysembryoplastic neuroepithelial tumor 9.9 GFAP S100B
24 meningioma, familial 9.9 GFAP PTEN
25 spindle cell rhabdomyosarcoma 9.9 GFAP S100B
26 myxopapillary ependymoma 9.9 GFAP S100B
27 papillary ependymoma 9.8 GFAP S100B
28 chordoid glioma 9.8 GFAP S100B
29 syringoma 9.8 GFAP S100B
30 angiocentric glioma 9.8 GFAP S100B
31 pineocytoma 9.8 GFAP S100B
32 papilloma of choroid plexus 9.8 GFAP S100B
33 granular cell tumor 9.8 GFAP S100B
34 traumatic brain injury 9.8 GFAP S100B
35 brain injury 9.8 GFAP S100B
36 optic nerve glioma 9.8 GFAP S100B
37 meningioma, radiation-induced 9.8 GFAP S100B
38 myoepithelioma 9.8 GFAP S100B
39 megalencephaly 9.8 PTEN S100B
40 ganglioglioma 9.8 GFAP S100B
41 neurilemmoma 9.8 GFAP S100B
42 neuroma 9.8 GFAP S100B
43 supratentorial cancer 9.7 GFAP IDH2 PTEN
44 cerebrum cancer 9.7 GFAP IDH2 PTEN
45 grade iii astrocytoma 9.7 GFAP IDH2 PTEN
46 central nervous system cancer 9.7 GFAP IDH2 PTEN
47 nervous system cancer 9.7 GFAP IDH2 PTEN
48 hemangioblastoma 9.7 GFAP S100B
49 neuronal ceroid-lipofuscinoses 9.7 GFAP S100B
50 pleomorphic adenoma 9.7 GFAP S100B

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to Gemistocytic Astrocytoma

Symptoms & Phenotypes for Gemistocytic Astrocytoma

UMLS symptoms related to Gemistocytic Astrocytoma:


seizures, headache, motor manifestations, sensory manifestations

GenomeRNAi Phenotypes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.17 S100B
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.17 S100B
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.17 S100B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.17 S100B
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.17 PTEN S100B
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.17 PTEN

Drugs & Therapeutics for Gemistocytic Astrocytoma

Drugs for Gemistocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Dermatologic Agents Phase 3,Phase 1
4 Histamine Antagonists Phase 3
5 Neurotransmitter Agents Phase 3,Not Applicable
6 Gastrointestinal Agents Phase 3,Not Applicable
7 Serotonin Agents Phase 3
8 Serotonin Antagonists Phase 3
9 Anti-Allergic Agents Phase 3
10 Antipruritics Phase 3
11 Histamine H1 Antagonists Phase 3
12
Histamine Phosphate Phase 3 51-74-1 65513
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Verteporfin Approved, Investigational Phase 1 129497-78-5
15
Trioxsalen Approved Phase 1 3902-71-4 5585
16
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
18
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
19
Imetelstat Investigational Phase 1 868169-64-6
20 Dihematoporphyrin Ether Phase 1
21 Photosensitizing Agents Phase 1
22 Nicotinic Acids Phase 1
23 Vitamin B3 Phase 1
24 Vitamins Phase 1
25 Trace Elements Phase 1
26 Folate Phase 1
27 Vitamin B Complex Phase 1
28
Motesanib diphosphate Phase 1 850649-62-6 11450633
29 Protein Kinase Inhibitors Phase 1
30 Micronutrients Phase 1
31 Nutrients Phase 1
32 Vitamin B9 Phase 1
33
Dopamine Approved Not Applicable 62-31-7, 51-61-6 681
34 Fluorides Not Applicable
35 Dihydroxyphenylalanine Not Applicable
36 Dopamine Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
3 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
4 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 Not Applicable 18F-fluoro-dihydroxyphenylalanine
5 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

Anatomical Context for Gemistocytic Astrocytoma

MalaCards organs/tissues related to Gemistocytic Astrocytoma:

42
Brain, Thyroid, Spinal Cord

Publications for Gemistocytic Astrocytoma

Articles related to Gemistocytic Astrocytoma:

(show all 14)
# Title Authors Year
1
Synchronous gemistocytic astrocytoma IDH-mutant and oligodendroglioma IDH-mutant and 1p/19q-codeleted in a patient with CCDC26 polymorphism. ( 28550371 )
2017
2
Magnetic resonance imaging features of gemistocytic astrocytoma. ( 27766769 )
2016
3
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. ( 22115534 )
2012
4
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. ( 19756200 )
2009
5
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. ( 18987242 )
2008
6
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. ( 17536538 )
2007
7
Congenital gemistocytic astrocytoma in a fetus. ( 15864706 )
2006
8
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. ( 15193038 )
2004
9
Cystic gemistocytic astrocytoma in an adolescent. ( 29542484 )
1995
10
Multiple primary malignant tumours: gemistocytic astrocytoma with leptomeningeal spreading and papillary thyroid carcinoma. A case report. ( 2251958 )
1990
11
Gemistocytic astrocytoma in a one-month-old llama. ( 2365629 )
1990
12
A gemistocytic astrocytoma demonstrated high intensity on MR images. Protein hydration layer. ( 2398944 )
1990
13
Development of Hodgkin's disease in a patient receiving procarbazine, CCNU, and vincristine therapy for a gemistocytic astrocytoma. ( 626997 )
1978
14
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. ( 13301910 )
1955

Variations for Gemistocytic Astrocytoma

Expression for Gemistocytic Astrocytoma

Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for Gemistocytic Astrocytoma

Pathways related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.99 GFAP S100B
2 10.52 GFAP S100B

GO Terms for Gemistocytic Astrocytoma

Biological processes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to hypoxia GO:0071456 9.32 PTEN S100B
2 central nervous system development GO:0007417 9.26 PTEN S100B
3 memory GO:0007613 9.16 PTEN S100B
4 learning or memory GO:0007611 8.96 PTEN S100B
5 long-term synaptic potentiation GO:0060291 8.8 GFAP PTEN S100B

Sources for Gemistocytic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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