MCID: GMS001
MIFTS: 36

Gemistocytic Astrocytoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Gemistocytic Astrocytoma

MalaCards integrated aliases for Gemistocytic Astrocytoma:

Name: Gemistocytic Astrocytoma 12 58 54 15 71
Gemistocytic Astrocytic Tumor 12

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7005
MeSH 43 D001254
NCIt 49 C4321
SNOMED-CT 67 73982001
ICD10 via Orphanet 33 C71.9
UMLS via Orphanet 72 C0334581
Orphanet 58 ORPHA251604
UMLS 71 C0334581

Summaries for Gemistocytic Astrocytoma

MalaCards based summary : Gemistocytic Astrocytoma, also known as gemistocytic astrocytic tumor, is related to fibrillary astrocytoma and glial tumor, and has symptoms including seizures, headache and motor manifestations. An important gene associated with Gemistocytic Astrocytoma is LINC01089 (Long Intergenic Non-Protein Coding RNA 1089), and among its related pathways/superpathways are Glioblastoma Multiforme and Central carbon metabolism in cancer. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and breast.

Related Diseases for Gemistocytic Astrocytoma

Diseases related to Gemistocytic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 fibrillary astrocytoma 31.6 TP53 PTEN MGMT IDH2 IDH1 GFAP
2 glial tumor 30.7 PTEN IDH1
3 hydrocephalus 29.9 TP53 S100B PTEN GFAP
4 glioblastoma multiforme 29.4 TP53 PTEN MGMT IDH2 IDH1 GFAP
5 grade iii astrocytoma 29.2 TP53 PTEN MGMT IDH2 IDH1 GFAP
6 giant cell glioblastoma 28.9 TP53 PTEN MGMT IDH2 IDH1 GFAP
7 oligodendroglioma 28.6 TP53 S100B PTEN MGMT IDH2 IDH1
8 astrocytoma 10.9
9 intracranial cysts 10.4 S100B GFAP
10 hydromyelia 10.4 S100B PTEN
11 papillary ependymoma 10.4 S100B GFAP
12 pineocytoma 10.4 S100B GFAP
13 cutaneous leiomyosarcoma 10.4 S100B GFAP
14 enchondroma 10.4 IDH2 IDH1
15 syringocystadenoma papilliferum 10.4 S100B GFAP
16 chordoid meningioma 10.4 S100B GFAP
17 gangliocytoma 10.3 PTEN GFAP
18 cytogenetically normal acute myeloid leukemia 10.3 IDH2 IDH1
19 intracranial chondrosarcoma 10.3 IDH2 IDH1
20 traumatic brain injury 10.3 S100B GFAP
21 brain injury 10.3 S100B GFAP
22 extraventricular neurocytoma 10.3 IDH1 GFAP
23 periosteal chondrosarcoma 10.3 IDH2 IDH1
24 spindle cell rhabdomyosarcoma 10.3 S100B GFAP
25 juxtacortical chondroma 10.3 IDH2 IDH1
26 adult oligodendroglioma 10.3 IDH2 IDH1
27 cerebellar astrocytoma 10.3 IDH2 IDH1
28 tanycytic ependymoma 10.3 IDH1 GFAP
29 optic nerve glioma 10.3 S100B GFAP
30 interval angle-closure glaucoma 10.3 IDH2 IDH1
31 clear cell meningioma 10.3 S100B GFAP
32 clear cell chondrosarcoma 10.3 IDH2 IDH1
33 undifferentiated pleomorphic sarcoma 10.3 IDH2 IDH1
34 chondroblastic osteosarcoma 10.3 IDH2 IDH1
35 high-grade astrocytoma 10.3 PTEN IDH1
36 clear cell ependymoma 10.3 IDH1 GFAP
37 spinal cord glioma 10.3 IDH1 GFAP
38 syringoma 10.3 S100B GFAP
39 myxopapillary ependymoma 10.3 S100B GFAP
40 frontal convexity meningioma 10.3 IDH1 GFAP
41 anaplastic oligodendroglioma 10.3 MGMT IDH2
42 intraductal papilloma 10.2 IDH2 IDH1
43 astroblastoma 10.2 IDH1 GFAP
44 urethra transitional cell carcinoma 10.2 TP53 GFAP
45 spinal cancer 10.2 IDH1 GFAP
46 mixed oligodendroglioma-astrocytoma 10.2 PTEN MGMT
47 cerebrovascular benign neoplasm 10.2 TP53 GFAP
48 multiple enchondromatosis, maffucci type 10.2 IDH2 IDH1
49 central nervous system primitive neuroectodermal neoplasm 10.2 TP53 GFAP
50 cervical mucinous adenocarcinoma 10.2 TP53 PTEN

Graphical network of the top 20 diseases related to Gemistocytic Astrocytoma:



Diseases related to Gemistocytic Astrocytoma

Symptoms & Phenotypes for Gemistocytic Astrocytoma

UMLS symptoms related to Gemistocytic Astrocytoma:


seizures, headache, motor manifestations, sensory manifestations

Drugs & Therapeutics for Gemistocytic Astrocytoma

Drugs for Gemistocytic Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Gastrointestinal Agents Phase 3
4 Neurotransmitter Agents Phase 3
5 Dermatologic Agents Phase 3
6 Antipruritics Phase 3
7 Histamine H1 Antagonists Phase 3
8 Serotonin Agents Phase 3
9 Histamine Antagonists Phase 3
10
Histamine Phosphate Phase 3 51-74-1 65513
11 Serotonin Antagonists Phase 3
12 Anti-Allergic Agents Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Verteporfin Approved, Investigational Phase 1 129497-78-5
15
Trioxsalen Approved Phase 1 3902-71-4 5585
16
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
17
Folic acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
18
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
19
Imetelstat Investigational Phase 1 868169-64-6
20 Photosensitizing Agents Phase 1
21 Dihematoporphyrin Ether Phase 1
22 Trace Elements Phase 1
23 Protein Kinase Inhibitors Phase 1
24 Vitamins Phase 1
25 Micronutrients Phase 1
26 Vitamin B3 Phase 1
27 Nutrients Phase 1
28 Vitamin B Complex Phase 1
29 Vitamin B9 Phase 1
30 Folate Phase 1
31
Motesanib diphosphate Phase 1 850649-62-6 11450633
32 Nicotinic Acids Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study Unknown status NCT00002647 Phase 1 verteporfin
3 A Phase 1 Study of Imetelstat, a Telomerase Inhibitor, in Children With Refractory or Recurrent Solid Tumors and Lymphomas Completed NCT01273090 Phase 1 imetelstat sodium

Search NIH Clinical Center for Gemistocytic Astrocytoma

Genetic Tests for Gemistocytic Astrocytoma

Anatomical Context for Gemistocytic Astrocytoma

MalaCards organs/tissues related to Gemistocytic Astrocytoma:

40
Brain, Thyroid, Breast, Spinal Cord, Eye, Bone, Skin

Publications for Gemistocytic Astrocytoma

Articles related to Gemistocytic Astrocytoma:

(show top 50) (show all 72)
# Title Authors PMID Year
1
p53 and PTEN gene mutations in gemistocytic astrocytomas. 54 61
9650746 1998
2
Immunohistochemical study on the distribution of alpha and beta subunits of S-100 protein in brain tumors. 54 61
1882640 1991
3
Relapsing Tumefactive Demyelination: A Case Report. 61
30585071 2018
4
Paradoxical results obtained with Ki67-labeling and PHH3-mitosis index in glial tumors: a literature analysis. 61
28853695 2017
5
Synchronous gemistocytic astrocytoma IDH-mutant and oligodendroglioma IDH-mutant and 1p/19q-codeleted in a patient with CCDC26 polymorphism. 61
28550371 2017
6
[Ultrastructural characteristics of gap junctions in human glial brain tumors]. 61
28295002 2017
7
Magnetic resonance imaging features of gemistocytic astrocytoma. 61
27766769 2016
8
Versatile utilization of real-time intraoperative contrast-enhanced ultrasound in cranial neurosurgery: technical note and retrospective case series. 61
26926064 2016
9
Intraoperative Squash Cytologic Features of Subependymal Giant Cell Astrocytoma. 61
27013816 2016
10
Alterations of the RRAS and ERCC1 genes at 19q13 in gemistocytic astrocytomas. 61
25192052 2014
11
Diagnostic pathway to amyotrophic lateral sclerosis (ALS): the significance of Babinski's sign in a unique patient and the necessity for a multidisciplinary approach. 61
23307452 2013
12
Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. 61
22115534 2012
13
Long-term follow-up in adult patients with low-grade glioma (WHO II) postoperatively irradiated. Analysis of prognostic factors. 61
24377015 2012
14
Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features. 61
23319187 2012
15
First step toward the "fingerprinting" of brain tumors based on synchrotron radiation X-ray fluorescence and multiple discriminant analysis. 61
21725853 2011
16
Early prognostic factors related to progression and malignant transformation of low-grade gliomas. 61
21889256 2011
17
Discrimination between low-grade oligodendrogliomas and diffuse astrocytoma with the aid of 11C-methionine positron emission tomography. 61
21214332 2011
18
Congenital brain tumors: diagnostic pitfalls and therapeutic interventions. 61
21464236 2011
19
Pilocytic astrocytoma with neoplastic gemistocytes undergoing spontaneous transformation to glioblastoma multiforme without prior radiotherapy. 61
21349721 2011
20
Rare primary tumours of the hypothalamus in adults: clinical course and surgical treatment. 61
21225516 2010
21
Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy. 61
20197146 2010
22
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. 61
19756200 2009
23
Immunohistochemical features of a feline spinal cord gemistocytic astrocytoma. 61
18987242 2008
24
Cytologic features of subependymal giant cell astrocytom: a review of 7 cases. 61
18702362 2008
25
Pediatric brain tumours at a tertiary care hospital in Karachi. 61
18159977 2007
26
Cytologic characteristics of subependymal giant cell astrocytoma in squash smears: morphometric comparisons with gemistocytic astrocytoma and giant cell glioblastoma. 61
17536538 2007
27
Expression of two testis-specific genes, TSGA10 and SYCP3, in different cancers regarding to their pathological features. 61
17920210 2007
28
Congenital gemistocytic astrocytoma in a fetus. 61
15864706 2006
29
Definition and diagnostic implications of gemistocytic astrocytomas: a pathological perspective. 61
16132490 2006
30
CXCL12 expression is predictive of a shorter time to tumor progression in low-grade glioma: a single-institution study in 50 patients. 61
16132525 2005
31
Postoperative irradiation of incompletely excised gemistocytic astrocytomas. Clinical outcome and prognostic factors. 61
15827694 2005
32
Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell adhesion molecule L1 in tumour invasion. 54
15677537 2005
33
[Results of the operative treatment of intramedullary gliomas]. 61
15654672 2004
34
Astroblastoma: a case report. 61
15483362 2004
35
Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas. 61
15118874 2004
36
[A multicentric glioma presenting different pathological appearances: a case report]. 61
15287489 2004
37
November 2003: neonatal female with congenital brain tumor. Congenital gemistocytic astrocytoma. 61
15193038 2004
38
Giant cell ependymoma of the spinal cord. Case report and review of the literature. 61
14748579 2004
39
[Diagnosis of brain gliomas in stereotactic biopsy assisted by optical neuro-navigation system]. 61
15049161 2004
40
Radiotherapy in supratentorial gliomas. A study of 821 cases. 61
14628126 2003
41
Genetic evidence of the neoplastic nature of gemistocytes in astrocytomas. 61
11699553 2001
42
Detection of a novel point mutation in the p53 gene in grade II astrocytomas by PCR-SSCP analysis with additional Klenow treatment. 61
11724349 2001
43
Patterns of cyclooxygenase-1 and -2 expression in human gliomas in vivo. 61
10483780 1999
44
[Subependymal giant cell astrocytoma associated with tuberous sclerosis exhibiting rapid regrowth after 17 years: a case report]. 61
10396738 1999
45
Extracellular matrix-induced cell migration from glioblastoma biopsy specimens in vitro. 61
10090669 1999
46
[Clinical results of supratentorial astrocytoma grade II]. 61
10065446 1999
47
Modifying radical radiotherapy in high grade gliomas; shortening the treatment time through acceleration. 61
10030251 1999
48
Clonal analysis of gliomas. 61
9343324 1997
49
Proliferation of gemistocytic cells and glial fibrillary acidic protein (GFAP)-positive oligodendroglial cells in gliomas: a MIB-1/GFAP double labeling study. 54
8773153 1996
50
Meningeal rhabdomyosarcoma. Report of a case with cytologic, immunohistologic and ultrastructural studies. 61
7762328 1995

Variations for Gemistocytic Astrocytoma

Expression for Gemistocytic Astrocytoma

Search GEO for disease gene expression data for Gemistocytic Astrocytoma.

Pathways for Gemistocytic Astrocytoma

Pathways related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.38 TP53 PTEN MGMT
2 10.64 TP53 PTEN IDH1
3
Show member pathways
10.07 IDH2 IDH1

GO Terms for Gemistocytic Astrocytoma

Biological processes related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.63 TP53 S100B PTEN
2 cellular response to hypoxia GO:0071456 9.58 TP53 S100B PTEN
3 response to organic cyclic compound GO:0014070 9.54 PTEN MGMT IDH1
4 response to ethanol GO:0045471 9.5 TP53 PTEN MGMT
5 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.48 TP53 PTEN
6 2-oxoglutarate metabolic process GO:0006103 9.43 IDH2 IDH1
7 NADP metabolic process GO:0006739 9.26 IDH2 IDH1
8 isocitrate metabolic process GO:0006102 9.16 IDH2 IDH1
9 long-term synaptic potentiation GO:0060291 9.13 S100B PTEN GFAP
10 glyoxylate cycle GO:0006097 8.62 IDH2 IDH1

Molecular functions related to Gemistocytic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
2 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1

Sources for Gemistocytic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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43 MeSH
44 MESH via Orphanet
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48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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