MCID: GNR003
MIFTS: 42

Generalized Atherosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Generalized Atherosclerosis

MalaCards integrated aliases for Generalized Atherosclerosis:

Name: Generalized Atherosclerosis 12 15 70
Generalised Atherosclerosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2347
ICD9CM 34 440.9
NCIt 50 C35767
SNOMED-CT 67 367108003
ICD10 32 I70.9 I70.91
UMLS 70 C0017327

Summaries for Generalized Atherosclerosis

MalaCards based summary : Generalized Atherosclerosis, also known as generalised atherosclerosis, is related to impotence and angina pectoris. An important gene associated with Generalized Atherosclerosis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Adipogenesis. Affiliated tissues include heart, endothelial and liver, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Generalized Atherosclerosis

Diseases related to Generalized Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 505)
# Related Disease Score Top Affiliating Genes
1 impotence 30.4 INS ALB ACE
2 angina pectoris 29.8 INS IL6 CRP ACE
3 hypercholesterolemia, familial, 1 29.8 INS CRP APOE APOB ACE
4 carotid stenosis 29.5 VWF REN CRP APOE ACE
5 peripheral artery disease 29.1 VWF IL6 CRP APOE APOB ACE
6 nephrotic syndrome 28.9 REN IL6 CRP APOE APOB ALB
7 coronary heart disease 1 28.9 SERPINE1 INS CRP APOE APOB ACE
8 atherosclerosis susceptibility 28.8 VWF SERPINE1 PLA2G7 INS IL6 CRP
9 kidney disease 28.0 SERPINE1 REN INS IL6 CRP APOE
10 heart disease 27.7 VWF SERPINE1 REN INS IL6 CRP
11 hypertension, essential 27.0 VWF SERPINE1 REN PLA2G7 PLA2G1B INS
12 acute dacryoadenitis 10.4 CRP ACE
13 mediastinum teratoma 10.4 CRP ACE
14 cardiac tuberculosis 10.4 CRP ACE
15 chronic duodenal ileus 10.4 CRP ALB
16 anterior scleritis 10.4 CRP ACE
17 malignant otitis externa 10.4 INS CRP
18 uvulitis 10.4 INS CRP
19 multiple cranial nerve palsy 10.4 CRP ACE
20 posterior scleritis 10.4 CRP ACE
21 tolosa-hunt syndrome 10.4 CRP ACE
22 moderate and severe traumatic brain injury 10.4 APOE ACE
23 chronic orbital inflammation 10.4 CRP ACE
24 glossopharyngeal nerve disease 10.4 CRP ACE
25 granulomatous angiitis 10.4 CRP ACE
26 cavernous sinus thrombosis 10.4 INS CRP
27 peptic ulcer perforation 10.4 CRP ALB
28 urinary tract infection 10.4 CRP ACE
29 ankylosing spondylitis 3 10.4 CRP ALB
30 ankylosing spondylitis 1 10.4 CRP ALB
31 tuberculous peritonitis 10.4 CRP ALB
32 neurogenic arthropathy 10.4 INS CRP
33 neuroretinitis 10.4 CRP ACE
34 epidural abscess 10.4 CRP ALB
35 chronic intestinal vascular insufficiency 10.4 CRP ALB
36 acalculous cholecystitis 10.4 CRP ALB
37 optic papillitis 10.4 CRP ACE
38 meningovascular neurosyphilis 10.4 CRP ALB
39 glomerular disease 10.4 ALB ACE
40 hydrops of gallbladder 10.4 CRP ALB
41 familial lcat deficiency 10.4 APOE ALB
42 splenic abscess 10.4 CRP ALB
43 ascending cholangitis 10.4 CRP ALB
44 pyeloureteritis cystica 10.4 REN CRP
45 duodenal obstruction 10.3 CRP ALB
46 mononeuritis of upper limb and mononeuritis multiplex 10.3 CRP ACE
47 mononeuritis multiplex 10.3 CRP ACE
48 gastrointestinal tuberculosis 10.3 CRP ALB
49 intestinal tuberculosis 10.3 CRP ALB
50 aspiration pneumonitis 10.3 CRP ALB

Comorbidity relations with Generalized Atherosclerosis via Phenotypic Disease Network (PDN): (show top 50) (show all 68)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Alzheimer Disease Anthracosis
Anxiety Aortic Atherosclerosis
Aortic Valve Disease 1 Basilar Artery Insufficiency
Benign Essential Hypertension Bronchitis
Bronchopneumonia Cardiac Arrest
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Intestinal Vascular Insufficiency
Chronic Kidney Disease Cystitis
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Diabetic Polyneuropathy
Dysthymic Disorder Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Gout
Heart Disease Hypertension, Essential
Hypertensive Encephalopathy Hypoglycemia
Hypothyroidism Intermediate Coronary Syndrome
Intestinal Obstruction Intracranial Embolism
Intracranial Thrombosis Iron Deficiency Anemia
Kidney Disease Labyrinthitis
Left Bundle Branch Hemiblock Malignant Essential Hypertension
Mitral Valve Disease Myocarditis
Osteoarthritis Osteoporosis
Paralytic Ileus Parkinson Disease, Late-Onset

Graphical network of the top 20 diseases related to Generalized Atherosclerosis:



Diseases related to Generalized Atherosclerosis

Symptoms & Phenotypes for Generalized Atherosclerosis

MGI Mouse Phenotypes related to Generalized Atherosclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 ACE ALB APOB APOE CRP IL6
2 cardiovascular system MP:0005385 10.07 ACE ALB APOB APOE CRP IL6
3 immune system MP:0005387 10 ACE ALB APOB APOE CRP IL6
4 liver/biliary system MP:0005370 9.76 ACE ALB APOB APOE IL6 INS
5 mortality/aging MP:0010768 9.7 ACE ALB APOB APOE IL6 INS
6 renal/urinary system MP:0005367 9.17 ACE ALB APOE IL6 INS REN

Drugs & Therapeutics for Generalized Atherosclerosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Association of the Intrarenal Resistance Index (RI) of Transplanted Kidneys With Generalized Atherosclerosis Unknown status NCT01001065
2 Carotid Intima Media Thickness in Patients With Epistaxis: a Surrogate Marker for Generalised Atherosclerosis Completed NCT03092973

Search NIH Clinical Center for Generalized Atherosclerosis

Genetic Tests for Generalized Atherosclerosis

Anatomical Context for Generalized Atherosclerosis

MalaCards organs/tissues related to Generalized Atherosclerosis:

40
Heart, Endothelial, Liver, Skin, Eye, Kidney, Lung

Publications for Generalized Atherosclerosis

Articles related to Generalized Atherosclerosis:

(show top 50) (show all 328)
# Title Authors PMID Year
1
Donor-derived vancomycin-resistant enterococci transmission and bloodstream infection after intestinal transplantation. 61
33160394 2020
2
Prevalence of Lower Extremity Arterial Disease as Measured by Low Ankle-Brachial Index in Patients with Acute Cerebral Ischemic Events. 61
33053853 2020
3
Biomarker Utility for Peripheral Artery Disease Diagnosis in Real Clinical Practice: A Prospective Study. 61
32962217 2020
4
Selection of Patients for Angioplasty for Treatment of Atherosclerotic Renovascular Disease: Predicting Responsive Patients. 61
31996895 2020
5
Intraepidermal Nerve Fiber Density in Postmortem Skin: A Novel Approach. 61
31743249 2019
6
Does Socioeconomic Status Influence the Risk of Subclinical Atherosclerosis?: A Mediation Model. 61
31345427 2019
7
Intima-media thickness of femoral arteries and carotids among an adult hypertensive Nigerian population: A case-control study to assess their use as surrogate markers of atherosclerosis. 61
31417017 2019
8
[The influence of treatments in the field of hydrotherapy and controlled physical training on the temperature of lower limbs in patients with atherosclerotic peripheral vascular disease]. 61
31152534 2019
9
Non-invasive ultrasound-based imaging of atherosclerosis. 61
30324866 2019
10
Effects of 12-months treatment with zoledronate or teriparatide on intima-media thickness of carotid artery in women with postmenopausal osteoporosis: A pilot study. 61
30791743 2019
11
Carotid intima media thickness and ankle brachial index are inversely associated in subjects with and without diabetes. 61
30073874 2018
12
Association between increased serum alkaline phosphatase and the coronary slow flow phenomenon. 61
29973151 2018
13
Case report-Rapid regression of xanthomas under lipoprotein apheresis in a boy with homozygous familial hypercholesterolemia. 61
29866529 2018
14
Mechanisms of vascular aging: What can we learn from Hutchinson-Gilford progeria syndrome? 61
29602596 2018
15
Carotid Atherosclerosis Detected by Ultrasonography: A National Cross-Sectional Study. 61
29622590 2018
16
Measurement of peripheral blood flow in patients with peripheral artery disease: Methods and considerations. 61
29458301 2018
17
The Effect of Non-Stroke Cardiovascular Disease States on Risk for Cognitive Decline and Dementia: A Systematic and Meta-Analytic Review. 61
28856507 2018
18
The Importance of Breakfast in Atherosclerosis Disease: Insights From the PESA Study. 61
28982495 2017
19
Asymptomatic Plaques of Lower Peripheral Arteries and Their Association with Cardiovascular Disease: An Autopsy Study. 61
28367862 2017
20
Renal Artery Stenosis: New Findings from the CORAL Trial. 61
28752274 2017
21
Prevalence of calcified carotid artery atheromas on digital panoramic images among perimenopausal and postmenopausal African American women. 61
28407989 2017
22
[RESULTS OF TREATMENT IN PATIENTS, SUFFERING STENOSIS OF CAROTID ARTERIES IN COMBINATION WITH DISEASES OF OTHER SYSTEMS]. 61
30273470 2017
23
Impressive predictive value of ankle-brachial index for very long-term outcomes in patients with cardiovascular disease: IMPACT-ABI study. 61
28617815 2017
24
Involvement of the Coronary Bed in Patients with Coronary Heart Disease against the Background of Primarily Coronary and Generalized Atherosclerosis. 61
27905030 2016
25
Hemorheological alterations in carotid artery stenosis. 61
26890237 2016
26
Uterine Arcuate Artery Calcification on Transvaginal Sonography May Correlate With Known Risk Factors for Atherosclerosis. 61
27091911 2016
27
Abdominal Aortic Calcification Identified on Lateral Spine Images From Bone Densitometers Are a Marker of Generalized Atherosclerosis in Elderly Women. 61
26603153 2016
28
[A rare case of mobile atherosclerotic plaque with a high embolic potential in the femoral artery]. 61
26967238 2016
29
Diagnosing Mitochondrial Disorder without Sophisticated Means. 61
26615382 2015
30
Prevalence, Vascular Distribution, and Multiterritorial Extent of Subclinical Atherosclerosis in a Middle-Aged Cohort: The PESA (Progression of Early Subclinical Atherosclerosis) Study. 61
25882487 2015
31
Distribution and natural course of intracranial vessel wall lesions in patients with ischemic stroke or TIA at 7.0 Tesla MRI. 61
25577517 2015
32
Fast segmentation of the femoral arteries from 3D MR images: A tool for rapid assessment of peripheral arterial disease. 61
25979037 2015
33
Under-expression of α8 integrin aggravates experimental atherosclerosis. 61
25511181 2015
34
Chronic complete thrombosis of abdominal aortic aneurysm: an unusual presentation of an unusual complication. 61
24567504 2015
35
[Conventional and novel cardiovascular risk factors and predisposition to the development of atherosclerosis]. 61
26226683 2015
36
Ankle-Brachial Index but Neither Intima Media Thickness Nor Coronary Artery Calcification is Associated With Mild Cognitive Impairment. 61
26401565 2015
37
[Complicated mesenteric ischaemia]. 61
25472564 2014
38
Comparison of carotid and lower limb atherosclerotic lesions in both previously known and newly diagnosed type 2 diabetes mellitus. 61
25422776 2014
39
Asymptomatic peripheral artery disease and antiplatelet management. 61
25147008 2014
40
Atherosclerotic renal artery stenosis as a cause for hypertension in an adolescent patient. 61
24531663 2014
41
[Screening of carotid arteries before surgery: when does preoperative duplex ultrasound make sense?]. 61
24449082 2014
42
The Association between Carotid Intima-Media Thickness and the Duration of Type 1 Diabetes in Children. 61
25562016 2014
43
Complex atheromatous plaques in the descending aorta and the risk of stroke: a systematic review and meta-analysis. 61
24788969 2014
44
MiRNAs in peripheral artery disease - something gripping this way comes. 61
24797047 2014
45
Lower atherosclerotic burden in familial abdominal aortic aneurysm. 61
24239112 2014
46
Association between renal vasculature changes and generalized atherosclerosis: an autopsy survey. 61
24096900 2014
47
Non-dipping heart rate and microalbuminuria in type 2 diabetes mellitus. 61
24969141 2014
48
Granulomatous pancreatitis in a patient with acute manifested insulin-dependent diabetes mellitus. 61
24711951 2014
49
Peripheral arterial disease: implications beyond the peripheral circulation. 61
23221278 2013
50
The response of carotid intima-media thickness to medical treatment is correlated with that of intracranial atherosclerosis. 61
24285964 2013

Variations for Generalized Atherosclerosis

Expression for Generalized Atherosclerosis

Search GEO for disease gene expression data for Generalized Atherosclerosis.

Pathways for Generalized Atherosclerosis

GO Terms for Generalized Atherosclerosis

Cellular components related to Generalized Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 VWF SERPINE1 REN PLA2G7 PLA2G1B INS
2 endoplasmic reticulum lumen GO:0005788 9.72 INS IL6 APOE APOB ALB
3 platelet alpha granule lumen GO:0031093 9.58 VWF SERPINE1 ALB
4 endosome lumen GO:0031904 9.48 INS APOB
5 endocytic vesicle lumen GO:0071682 9.46 APOE APOB
6 chylomicron GO:0042627 9.43 APOE APOB
7 high-density lipoprotein particle GO:0034364 9.43 PLA2G7 APOE APOB
8 extracellular space GO:0005615 9.4 VWF SERPINE1 REN PLA2G7 PLA2G1B INS
9 intermediate-density lipoprotein particle GO:0034363 9.37 APOE APOB
10 low-density lipoprotein particle GO:0034362 9.33 PLA2G7 APOE APOB

Biological processes related to Generalized Atherosclerosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.88 IL6 APOE APOB ALB
2 lipid catabolic process GO:0016042 9.78 PLA2G7 PLA2G1B APOB
3 platelet degranulation GO:0002576 9.77 VWF SERPINE1 ALB
4 defense response to Gram-positive bacterium GO:0050830 9.73 PLA2G1B IL6 CRP
5 positive regulation of interleukin-8 production GO:0032757 9.63 SERPINE1 PLA2G1B IL6
6 positive regulation of lipid biosynthetic process GO:0046889 9.62 INS APOE
7 high-density lipoprotein particle remodeling GO:0034375 9.61 APOE ALB
8 fatty acid homeostasis GO:0055089 9.6 INS APOE
9 amyloid-beta metabolic process GO:0050435 9.58 REN ACE
10 negative regulation of blood coagulation GO:0030195 9.57 SERPINE1 APOE
11 angiotensin maturation GO:0002003 9.55 REN ACE
12 chylomicron assembly GO:0034378 9.54 APOE APOB
13 chylomicron remodeling GO:0034371 9.52 APOE APOB
14 negative regulation of lipid storage GO:0010888 9.51 IL6 CRP
15 intermembrane lipid transfer GO:0120009 9.5 GRAMD1C APOE APOB
16 chylomicron remnant clearance GO:0034382 9.49 APOE APOB
17 very-low-density lipoprotein particle clearance GO:0034447 9.48 APOE APOB
18 lipoprotein catabolic process GO:0042159 9.43 APOE APOB
19 acute-phase response GO:0006953 9.43 INS IL6 CRP
20 lipoprotein biosynthetic process GO:0042158 9.4 APOE APOB
21 positive regulation of dendritic spine maintenance GO:1902952 9.37 INS APOE
22 cellular protein metabolic process GO:0044267 9.35 INS IL6 APOE APOB ALB
23 low-density lipoprotein particle remodeling GO:0034374 9.33 PLA2G7 APOE APOB
24 neutrophil mediated immunity GO:0002446 8.8 PLA2G1B IL6 ACE

Molecular functions related to Generalized Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.43 PLA2G7 APOE APOB
2 protease binding GO:0002020 9.33 VWF SERPINE1 INS
3 insulin-like growth factor receptor binding GO:0005159 9.32 REN INS
4 low-density lipoprotein particle receptor binding GO:0050750 9.13 CRP APOE APOB
5 intermembrane cholesterol transfer activity GO:0120020 8.8 GRAMD1C APOE APOB

Sources for Generalized Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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