MCID: GNR003
MIFTS: 33

Generalized Atherosclerosis

Categories: Cardiovascular diseases

Aliases & Classifications for Generalized Atherosclerosis

MalaCards integrated aliases for Generalized Atherosclerosis:

Name: Generalized Atherosclerosis 12 15 73
Generalised Atherosclerosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2347
ICD10 33 I70.91 I70.9
ICD9CM 35 440.9
NCIt 50 C35767
SNOMED-CT 68 367108003 39823006
UMLS 73 C0017327

Summaries for Generalized Atherosclerosis

MalaCards based summary : Generalized Atherosclerosis, also known as generalised atherosclerosis, is related to coronary heart disease 1 and heart disease. An important gene associated with Generalized Atherosclerosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are Statin Pathway and A-beta Pathways: Uptake and Degradation. The drugs Simvastatin and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone, and related phenotypes are Decreased free cholesterol and Increased LDL uptake

Related Diseases for Generalized Atherosclerosis

Diseases related to Generalized Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 coronary heart disease 1 28.8 ACE APOE CRP
2 heart disease 28.2 ACE APOE CRP
3 hypertensive nephropathy 10.4 ACE CYP4A11
4 moderate and severe traumatic brain injury 10.4 ACE APOE
5 cerebral atherosclerosis 10.3 ACE APOE
6 aortic atherosclerosis 10.3 ACE APOE
7 hemorrhage, intracerebral 10.3 ACE APOE
8 angina pectoris 10.2 ACE CRP
9 subdural empyema 10.2 ACE CRP
10 systolic heart failure 10.2 ACE CRP
11 hermansky-pudlak syndrome 3 10.2 APOE SELP
12 arteritic anterior ischemic optic neuropathy 10.2 ACE CRP
13 granulomatous hepatitis 10.2 ACE CRP
14 multiple cranial nerve palsy 10.2 ACE CRP
15 vascular dementia 10.1 ACE APOE
16 interstitial nephritis 10.1 ACE CRP
17 heart conduction disease 10.1 ACE CRP
18 pyelonephritis 10.1 ACE CRP
19 aortic valve disease 1 10.1 ACE CRP
20 pulmonary edema 10.1 ACE CRP
21 pyosalpinx 10.1 APOE CRP
22 end stage renal failure 10.0 ACE CRP
23 venous insufficiency 10.0 CRP SELP
24 glucose metabolism disease 10.0 ACE CRP
25 aortic disease 10.0 APOE CRP
26 thrombocytosis 9.9 CRP SELP
27 aortic valve disease 2 9.9 ACE CRP
28 autoinflammation, lipodystrophy, and dermatosis syndrome 9.9 CRP SELP
29 urinary system disease 9.9 ACE CRP
30 aortic aneurysm, familial abdominal, 1 9.9 APOE CRP
31 immune system disease 9.8 ACE CRP
32 acquired metabolic disease 9.8 ACE CRP
33 impotence 9.8
34 hyperalphalipoproteinemia 1 9.8 APOE PLTP
35 tangier disease 9.7 APOE PLTP
36 ischemic heart disease 9.6 ACE APOE CRP
37 intermediate coronary syndrome 9.6 ACE CRP SELP
38 intermittent claudication 9.6 ACE CRP SELP
39 peripheral artery disease 9.6 ACE CRP SELP
40 coronary stenosis 9.6 ACE APOE CRP
41 carotid artery disease 9.6 ACE APOE CRP
42 sleep apnea 9.6 ACE APOE CRP
43 lipid metabolism disorder 9.6 ACE APOE CRP
44 peripheral vascular disease 9.6 ACE CRP SELP
45 systemic scleroderma 9.6 ACE CRP SELP
46 acute myocardial infarction 9.6 ACE CRP SELP
47 hypertension, essential 9.6 ACE CRP SELP
48 adiposis dolorosa 9.6
49 aging 9.6
50 body mass index quantitative trait locus 1 9.6

Comorbidity relations with Generalized Atherosclerosis via Phenotypic Disease Network (PDN): (show top 50) (show all 70)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Alzheimer Disease Anthracosis
Anxiety Aortic Atherosclerosis
Aortic Valve Disease 1 Basilar Artery Insufficiency
Benign Essential Hypertension Bronchitis
Bronchopneumonia Cardiac Arrest
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Chronic Intestinal Vascular Insufficiency
Chronic Kidney Failure Chronic Myocardial Ischemia
Cystitis Decubitus Ulcer
Deficiency Anemia Dermatomycosis
Diabetic Polyneuropathy Dysthymic Disorder
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Gout Heart Disease
Hypertension, Essential Hypertensive Encephalopathy
Hypoglycemia Hypothyroidism
Intermediate Coronary Syndrome Intestinal Obstruction
Intracranial Embolism Intracranial Thrombosis
Iron Deficiency Anemia Ischemic Heart Disease
Kidney Disease Labyrinthitis
Left Bundle Branch Hemiblock Malignant Essential Hypertension
Mitral Valve Disease Myocarditis
Osteoarthritis Osteoporosis

Graphical network of the top 20 diseases related to Generalized Atherosclerosis:



Diseases related to Generalized Atherosclerosis

Symptoms & Phenotypes for Generalized Atherosclerosis

GenomeRNAi Phenotypes related to Generalized Atherosclerosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 9.13 APOE PLTP SELP
2 Increased LDL uptake GR00340-A-1 8.62 APOE SELP

Drugs & Therapeutics for Generalized Atherosclerosis

Drugs for Generalized Atherosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
3 Hypolipidemic Agents Phase 4
4 Anticholesteremic Agents Phase 4
5 Lipid Regulating Agents Phase 4
6 Antimetabolites Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Simvastatin Reduces Circulating Osteoprotegerin Levels in Patients With Type 2 Diabetes Completed NCT00471549 Phase 4 Statin (simvastatin)
2 Efficacy and Safety Study of NV1FGF in Patients With Severe Peripheral Artery Occlusive Disease. Completed NCT00798005 Phase 2 XRP0038 (NV1FGF)
3 Association of the Intrarenal Resistance Index (RI) of Transplanted Kidneys With Generalized Atherosclerosis Unknown status NCT01001065
4 Carotid Intima Media Thickness (CIMT) in Epistaxis Completed NCT03092973
5 Utility of Clinical Examination in the Noninvasive Prediction of Aortic Atheroma - A Prospective Study Completed NCT00590616
6 Atrial Fibrillation Registry for Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study. Completed NCT01161251

Search NIH Clinical Center for Generalized Atherosclerosis

Genetic Tests for Generalized Atherosclerosis

Anatomical Context for Generalized Atherosclerosis

MalaCards organs/tissues related to Generalized Atherosclerosis:

41
Kidney, Heart, Bone

Publications for Generalized Atherosclerosis

Articles related to Generalized Atherosclerosis:

(show all 23)
# Title Authors Year
1
Involvement of the Coronary Bed in Patients with Coronary Heart Disease against the Background of Primarily Coronary and Generalized Atherosclerosis. ( 27905030 )
2016
2
Abdominal Aortic Calcification Identified on Lateral Spine Images From Bone Densitometers Are a Marker of Generalized Atherosclerosis in Elderly Women. ( 26603153 )
2016
3
Association Between Renal Vasculature Changes and Generalized Atherosclerosis: An Autopsy Survey. ( 24096900 )
2013
4
Carotid Intima Media Thickness as a Reflection of Generalized Atherosclerosis is Related to Body Mass Index in Ischemic Stroke Patients. ( 23626961 )
2013
5
Usefulness of carotid intima-media thickness measurement as an indicator of generalized atherosclerosis: findings from autopsy analysis. ( 23092826 )
2012
6
Adiposis dolorosa with hypercholesterolemia and premature severe generalized atherosclerosis. ( 19817260 )
2009
7
Plaque in superficial femoral arteries indicates generalized atherosclerosis and vulnerability to coronary death: an autopsy study. ( 18241752 )
2008
8
Intracardiac calcification is a marker of generalized atherosclerosis. ( 17875954 )
2007
9
Re: Penile duplex pharmaco-ultrasonography of cavernous arteries in men with erectile dysfunction and generalized atherosclerosis. ( 17209882 )
2007
10
Penile duplex pharmaco-ultrasonography of cavernous arteries in men with erectile dysfunction and generalized atherosclerosis. ( 16893400 )
2006
11
Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age. ( 16009894 )
2005
12
Initial validation of a novel rat model of vasculogenic erectile dysfunction with generalized atherosclerosis. ( 15889122 )
2005
13
Generalized atherosclerosis sparing the transplanted kidney in Schimke disease. ( 15054643 )
2004
14
The ankle-brachial blood pressure index as a risk indicator of generalized atherosclerosis. ( 16222633 )
2002
15
Ankle brachial index as a predictor of generalized atherosclerosis. ( 11868859 )
2001
16
Secondary retroperitoneal fibrosis associated with generalized atherosclerosis. ( 18212457 )
1999
17
Carotid artery intima-media thickness as an indicator of generalized atherosclerosis. ( 7964435 )
1994
18
The use of percutaneous transluminal angioplasty for renal artery stenosis in patients with generalized atherosclerosis. ( 6211555 )
1982
19
Congenital deficiency of cyclo-oxygenase in a woman with generalized atherosclerosis. ( 7336165 )
1981
20
Generalized atherosclerosis in a dog. ( 1249925 )
1976
21
Risk factors in the pathogenesis of atherosclerotic heart disease and generalized atherosclerosis. ( 4628363 )
1972
22
Clinical studies in blood lipid metabolism. IX. Effect of lipotropic agents on serum lipid partitions in fifty patients with generalized atherosclerosis; a three year study. ( 13158314 )
1954
23
Severe generalized atherosclerosis. ( 18911030 )
1948

Variations for Generalized Atherosclerosis

Expression for Generalized Atherosclerosis

Search GEO for disease gene expression data for Generalized Atherosclerosis.

Pathways for Generalized Atherosclerosis

Pathways related to Generalized Atherosclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.23 APOE PLTP
2 10.46 ACE APOE
3 10.04 CYP4A11 PLTP

GO Terms for Generalized Atherosclerosis

Cellular components related to Generalized Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 ACE APOE CRP PLTP SELP
2 high-density lipoprotein particle GO:0034364 8.96 APOE PLTP

Biological processes related to Generalized Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 high-density lipoprotein particle remodeling GO:0034375 8.96 APOE PLTP
2 positive regulation of cholesterol efflux GO:0010875 8.62 APOE PLTP

Molecular functions related to Generalized Atherosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid transporter activity GO:0005319 8.96 APOE PLTP
2 low-density lipoprotein particle receptor binding GO:0050750 8.62 APOE CRP

Sources for Generalized Atherosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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