MCID: GNT029
MIFTS: 39

Genetic Hypertension

Categories: Cardiovascular diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Genetic Hypertension

MalaCards integrated aliases for Genetic Hypertension:

Name: Genetic Hypertension 59 29 55

Classifications:



External Ids:

Orphanet 59 ORPHA156629

Summaries for Genetic Hypertension

MalaCards based summary : Genetic Hypertension is related to renovascular hypertension and arteries, anomalies of. An important gene associated with Genetic Hypertension is GRK4 (G Protein-Coupled Receptor Kinase 4), and among its related pathways/superpathways are PI3K / Akt Signaling and Aldosterone-regulated sodium reabsorption. The drugs Ouabain and Losartan have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, brain and kidney, and related phenotypes are no effect and Transferrin accumulation in the perinuclear area

Related Diseases for Genetic Hypertension

Diseases related to Genetic Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 renovascular hypertension 29.5 REN NPPA NOS3
2 arteries, anomalies of 29.5 REN NOS3 BMPR2
3 hypoaldosteronism 29.4 REN NPPA CYP11B2
4 apparent mineralocorticoid excess 29.1 REN NR3C2 HSD11B2
5 hypokalemia 29.0 REN NR3C2 HSD11B2
6 familial hypertension 27.6 WNK4 WNK1 REN NR3C2 NPPA HSD11B2
7 hypertension, essential 26.5 WNK4 WNK1 REN NR3C2 NPPA NOS3
8 renal artery disease 10.5 REN NOS3
9 aldosterone-producing adenoma 10.4 CYP11B2 ATP1A1
10 glucose metabolism disease 10.3 REN NOS3 DPP4
11 acquired metabolic disease 10.3 REN NOS3 DPP4
12 aortic coarctation 10.3 NOS3 GRK4 CYP11B2
13 renal tubular transport disease 10.2 WNK4 WNK1 REN
14 pulmonary edema 10.1 REN NPPA NOS3
15 pseudohypoaldosteronism, type i, autosomal dominant 10.1 REN NR3C2
16 autosomal dominant polycystic kidney disease 10.1 REN NOS3 ADD1
17 central sleep apnea 10.1 NPPA NOS3
18 steroid inherited metabolic disorder 10.0 REN HSD11B2 CYP11B2
19 sclerosing hepatic carcinoma 10.0 PTHLH CHGA
20 vasculogenic impotence 9.9 NPPA NOS3
21 pertussis 9.9
22 glucagonoma 9.8 VIP CHGA
23 anuria 9.8 REN NR3C2 HSD11B2
24 cortisone reductase deficiency 9.8 REN NR3C2 HSD11B2
25 heart valve disease 9.8 REN NR3C2 NPPA
26 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 9.8
27 hypertensive nephropathy 9.8
28 microvascular complications of diabetes 3 9.8
29 microvascular complications of diabetes 4 9.8
30 microvascular complications of diabetes 6 9.8
31 microvascular complications of diabetes 7 9.8
32 malignant hypertension 9.8
33 polyploidy 9.8
34 islet cell tumor 9.8 VIP PTHLH CHGA
35 liver sarcoma 9.8 PTHLH CHGA
36 endocrine organ benign neoplasm 9.7 REN CYP11B2 CHGA
37 cell type benign neoplasm 9.7 REN CYP11B2 CHGA
38 arthrogryposis, distal, type 3 9.7 WNK4 WNK1 REN NR3C2
39 vipoma 9.7 VIP CHGA
40 hypertriglyceridemia, familial 9.7
41 allergic hypersensitivity disease 9.7
42 vascular disease 9.7
43 diabetes insipidus 9.7
44 pseudohypoaldosteronism 9.7 WNK4 WNK1 REN NR3C2
45 congestive heart failure 9.7 REN NR3C2 NPPA
46 pre-eclampsia 9.6 REN NPPA NOS3 HSD11B2
47 progressive familial heart block, type ia 9.5
48 attention deficit-hyperactivity disorder 9.5
49 insulin-like growth factor i 9.5
50 aging 9.5

Graphical network of the top 20 diseases related to Genetic Hypertension:



Diseases related to Genetic Hypertension

Symptoms & Phenotypes for Genetic Hypertension

GenomeRNAi Phenotypes related to Genetic Hypertension according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.26 ADD1 ADD2 ANPEP ATP1A1 BMPR2 CHGA
2 Transferrin accumulation in the perinuclear area GR00356-A-3 8.8 BMPR2 WNK1 WNK4

MGI Mouse Phenotypes related to Genetic Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.36 ADD2 ANPEP ATP1A1 BMPR2 CHGA CYP11B2
2 homeostasis/metabolism MP:0005376 10.3 ADD1 ADD2 ATP1A1 BMPR2 CHGA CYP11B2
3 behavior/neurological MP:0005386 10.18 ADD2 ATP1A1 BMPR2 DRD1 HSD11B2 NOS3
4 hematopoietic system MP:0005397 10.18 ADD1 ADD2 ANPEP BMPR2 CYP11B2 DRD1
5 growth/size/body region MP:0005378 10.17 ADD1 BMPR2 CHGA CYP11B2 DPP4 DRD1
6 mortality/aging MP:0010768 10.1 ADD1 ATP1A1 BMPR2 CHGA DRD1 HSD11B2
7 muscle MP:0005369 9.96 ATP1A1 BMPR2 CHGA DRD1 HSD11B2 NOS3
8 nervous system MP:0003631 9.9 ADD1 ADD2 BMPR2 CHGA CYP11B2 DRD1
9 normal MP:0002873 9.56 BMPR2 DRD1 GRK4 HSD11B2 NOS3 PTHLH
10 renal/urinary system MP:0005367 9.4 ADD2 BMPR2 CHGA CYP11B2 HSD11B2 NOS3

Drugs & Therapeutics for Genetic Hypertension

Drugs for Genetic Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ouabain Approved Phase 2 630-60-4 439501
2
Losartan Approved Phase 2 114798-26-4 3961
3
Angiotensin II Approved, Investigational Phase 2 11128-99-7, 68521-88-0, 4474-91-3 172198
4
Imidazole Experimental, Investigational Phase 2 288-32-4 795
5 Angiotensinogen Phase 2
6 Angiotensin Receptor Antagonists Phase 2
7 Angiotensin II Type 1 Receptor Blockers Phase 2
8 Giapreza Phase 2
9 Anti-Arrhythmia Agents Phase 2
10 Antihypertensive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antihypertensive Effect of Different Doses of ROSTAFUROXIN in Comparison With Losartan, Assessed by Office and Ambulatory Blood Pressure Monitoring in a Hypertensive Population Selected According to a Specific Genetic Profile. Unknown status NCT03217825 Phase 2 Rostafuroxin;Losartan
2 Antihypertensive Effect of Different Doses of Rostafuroxin in Comparison With Losartan, Assessed by Office and Ambulatory Blood Pressure Monitoring in a Hypertensive Population Selected According to a Specific Genetic Profile Unknown status NCT01320397 Phase 2 Rostafuroxin;Rostafuroxin;Rostafuroxin;Losartan
3 Genetic Testing of Monogenic Hypertension in Chinese Population Unknown status NCT03012295

Search NIH Clinical Center for Genetic Hypertension

Genetic Tests for Genetic Hypertension

Genetic tests related to Genetic Hypertension:

# Genetic test Affiliating Genes
1 Genetic Hypertension 29

Anatomical Context for Genetic Hypertension

MalaCards organs/tissues related to Genetic Hypertension:

41
Smooth Muscle, Brain, Kidney, Heart, Endothelial, Testes, Adipocyte

Publications for Genetic Hypertension

Articles related to Genetic Hypertension:

(show top 50) (show all 826)
# Title Authors PMID Year
1
Proteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin. 9 38
17991725 2008
2
Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression. 9 38
16636192 2006
3
Role of central mineralocorticoid receptors in cardiovascular disease. 9 38
11353578 2001
4
Chromogranin A in human hypertension. Influence of heredity. 9 38
7607727 1995
5
[A new natriuretic factor acting like loop diuretics. Kinetics in normal and hypertensive rats]. 9 38
7755470 1994
6
Relationships among alterations in renal membrane sodium transport, renin and aminopeptidase M activities in genetic hypertension. 9 38
8102253 1993
7
Assignment of the chromogranin A (Chga) locus to homologous regions on mouse chromosome 12 and rat chromosome 6. 9 38
8406464 1993
8
Newly manufactured Marukome MK-34-1 miso with angiotensin-converting enzyme inhibitory activity and its antihypertensive effects in genetic hypertensive rat models. 38
30631160 2019
9
Metabolic Changes in Spontaneously Hypertensive Rat Hearts Precede Cardiac Dysfunction and Left Ventricular Hypertrophy. 38
30764689 2019
10
The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade. 38
30028078 2018
11
Abnormal CD161+ immune cells and retinoic acid receptor-related orphan receptor γt-mediate enhanced IL-17F expression in the setting of genetic hypertension. 38
28093217 2017
12
Consequences of lipopolysaccharide and n-3 polyunsaturated fatty acid administration on aortic function of spontaneously hypertensive rats. 38
28635612 2017
13
Electrophysiological properties and augmented catecholamine release from chromaffin cells of WKY and SHR rats contributing to the hypertension development elicited by chronic EtOH consumption. 38
28322841 2017
14
Apparent mineralocorticoid excess and the long term treatment of genetic hypertension. 38
26892095 2017
15
Adverse remodeling of the obtuse marginal artery in compensatory hypertrophied myocardium from spontaneously hypertensive rats. 38
27888779 2017
16
Altered contractile responses of arteries from spontaneously hypertensive rat: The role of endogenous mediators and membrane depolarization. 38
27721001 2016
17
Excitation-contraction coupling and excitation-transcription coupling in blood vessels: their possible interactions in hypertensive vascular remodeling. 38
27322009 2016
18
Personalized Therapy of Hypertension: the Past and the Future. 38
26915067 2016
19
Antihypertensive effects of oleuropein-enriched olive leaf extract in spontaneously hypertensive rats. 38
26593388 2016
20
Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats. 38
26255877 2015
21
NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4. 38
26371160 2015
22
Effects of Crocetin Esters and Crocetin from Crocus sativus L. on Aortic Contractility in Rat Genetic Hypertension. 38
26402666 2015
23
Differential expression and DNA methylation of angiotensin type 1A receptors in vascular tissues during genetic hypertension development. 38
25596947 2015
24
Impaired P2X signalling pathways in renal microvascular myocytes in genetic hypertension. 38
25514930 2015
25
Maternal treatment of spontaneously hypertensive rats with pentaerythritol tetranitrate reduces blood pressure in female offspring. 38
25385760 2015
26
Brain BDNF levels elevation induced by physical training is reduced after unilateral common carotid artery occlusion in rats. 38
25052557 2014
27
A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors. 38
24697296 2014
28
Energy metabolism in BPH/2J genetically hypertensive mice. 38
24305519 2014
29
Elevated blood pressure: Our family's fault? The genetics of essential hypertension. 38
24944762 2014
30
Nifedipine-sensitive blood pressure component in hypertensive models characterized by high activity of either sympathetic nervous system or renin-angiotensin system. 38
24397813 2014
31
Involvement of BKCa and KV potassium channels in cAMP-induced vasodilatation: their insufficient function in genetic hypertension. 38
24397812 2014
32
Genetics of hypertension: discoveries from the bench to human populations. 38
24133117 2014
33
Characterization of musclin as a new target for treatment of hypertension. 38
24734231 2014
34
[Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension]. 38
25474003 2014
35
Identifying multiple causative genes at a single GWAS locus. 38
24006081 2013
36
Down-regulation of CaV1.2 channels during hypertension: how fewer CaV1.2 channels allow more Ca(2+) into hypertensive arterial smooth muscle. 38
24167226 2013
37
Differential cardiotoxicity in response to chronic doxorubicin treatment in male spontaneous hypertension-heart failure (SHHF), spontaneously hypertensive (SHR), and Wistar Kyoto (WKY) rats. 38
23993975 2013
38
Role of collecting duct endothelin in control of renal function and blood pressure. 38
23986358 2013
39
Ca2+ sensitization and Ca2+ entry in the control of blood pressure and adrenergic vasoconstriction in conscious Wistar-Kyoto and spontaneously hypertensive rats. 38
24107733 2013
40
MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension. 38
23674521 2013
41
Effects of angiotensin II type 1 receptor blocker and adiponectin on adipocyte dysfunction in stroke-prone spontaneously hypertensive rats. 38
23876211 2013
42
Cerebral aqueduct block attenuates cardio-renal injuries in post-DOCA-NaCl-hypertensive Dahl R rats. 38
23466628 2013
43
α(2)-µ-Globulin fragment (a2-f) from kidneys of male rats. 38
23422892 2013
44
Age-dependent regulation of renal vasopressin V(1A) and V₂ receptors in rats with genetic hypertension: implications for the treatment of hypertension. 38
23246465 2013
45
An elevation in physical coupling of type 1 inositol 1,4,5-trisphosphate (IP3) receptors to transient receptor potential 3 (TRPC3) channels constricts mesenteric arteries in genetic hypertension. 38
23045459 2012
46
Transcriptional upregulation of α2δ-1 elevates arterial smooth muscle cell voltage-dependent Ca2+ channel surface expression and cerebrovascular constriction in genetic hypertension. 38
22949532 2012
47
Adding accessories for hypertension: α2δ-1 subunits upregulate CaV1.2 channels in arterial myocytes in a model of genetic hypertension. 38
22949527 2012
48
Neurohormonal modulation of the innate immune system is proinflammatory in the prehypertensive spontaneously hypertensive rat, a genetic model of essential hypertension. 38
22904093 2012
49
Integrated computational and experimental analysis of the neuroendocrine transcriptome in genetic hypertension identifies novel control points for the cardiometabolic syndrome. 38
22670052 2012
50
Blood pressure and renin-angiotensin system resetting in transgenic rats with elevated plasma Val5-angiotensinogen. 38
22728903 2012

Variations for Genetic Hypertension

Expression for Genetic Hypertension

Search GEO for disease gene expression data for Genetic Hypertension.

Pathways for Genetic Hypertension

Pathways related to Genetic Hypertension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.3 WNK4 WNK1 NOS3
2 10.7 NR3C2 HSD11B2 ATP1A1
3 10.66 NPPA BMPR2
4 10.54 ADD2 ADD1
5 10.39 WNK4 WNK1 ATP1A1 ADD1

GO Terms for Genetic Hypertension

Cellular components related to Genetic Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynaptic density GO:0014069 9.56 BMPR2 ATP1A1 ADD2 ADD1
2 mast cell granule GO:0042629 9.37 NPPA CHGA
3 caveola GO:0005901 9.13 NOS3 BMPR2 ATP1A1
4 F-actin capping protein complex GO:0008290 8.62 ADD2 ADD1
5 membrane GO:0016020 10.2 WNK4 WNK1 REN NR3C2 NOS3 HSD11B2
6 cytoplasm GO:0005737 10 WNK4 WNK1 REN PTHLH NR3C2 NPPA

Biological processes related to Genetic Hypertension according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.89 REN HSD11B2 DRD1 ATP1A1
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.75 VIP PTHLH DRD1
3 female pregnancy GO:0007565 9.73 PTHLH NPPA HSD11B2
4 vasodilation GO:0042311 9.61 NOS3 DRD1
5 regulation of the force of heart contraction GO:0002026 9.6 CHGA ATP1A1
6 regulation of blood vessel size GO:0050880 9.58 NPPA NOS3
7 barbed-end actin filament capping GO:0051016 9.57 ADD2 ADD1
8 peptide catabolic process GO:0043171 9.55 CPQ ANPEP
9 positive regulation of cardiac muscle contraction GO:0060452 9.54 NPPA CHGA
10 negative regulation of systemic arterial blood pressure GO:0003085 9.52 NPPA BMPR2
11 negative regulation of potassium ion transport GO:0043267 9.51 VIP NOS3
12 ion homeostasis GO:0050801 9.49 WNK4 WNK1
13 glucocorticoid biosynthetic process GO:0006704 9.48 HSD11B2 CYP11B2
14 positive regulation of sodium ion transmembrane transporter activity GO:2000651 9.46 WNK4 WNK1
15 positive regulation of ion transmembrane transporter activity GO:0032414 9.43 WNK4 WNK1
16 positive regulation of potassium ion import GO:1903288 9.4 WNK4 WNK1
17 negative regulation of sodium ion transport GO:0010766 9.37 WNK4 WNK1
18 negative regulation of pancreatic juice secretion GO:0090188 9.32 WNK4 WNK1
19 regulation of cellular process GO:0050794 9.26 WNK4 WNK1
20 regulation of blood volume by renal aldosterone GO:0002017 9.16 HSD11B2 CYP11B2
21 regulation of sodium ion transport GO:0002028 9.13 WNK1 NOS3 ATP1A1
22 regulation of blood pressure GO:0008217 9.02 REN NPPA NOS3 CHGA ATP1A1

Molecular functions related to Genetic Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 VIP PTHLH NPPA
2 peptide hormone receptor binding GO:0051428 9.16 VIP PTHLH
3 chloride channel inhibitor activity GO:0019869 8.96 WNK4 WNK1
4 potassium channel inhibitor activity GO:0019870 8.62 WNK4 WNK1

Sources for Genetic Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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