MCID: GNT167
MIFTS: 34

Genetic Obesity

Categories: Endocrine diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Genetic Obesity

MalaCards integrated aliases for Genetic Obesity:

Name: Genetic Obesity 58 36

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

KEGG 36 H02106
ICD10 via Orphanet 33 E66.8
Orphanet 58 ORPHA77828

Summaries for Genetic Obesity

KEGG : 36 Obesity predisposes to many diseases. It has a very heterogeneous phenotypic expression and the molecular mechanisms involved in its development are diverse. Although environmental factors are important, genes also have a significant role in its pathogenesis. Several genes that are involved in monogenic, syndromic and polygenic obesity, have been identified.

MalaCards based summary : Genetic Obesity is related to insulin-like growth factor i and fatty liver disease. An important gene associated with Genetic Obesity is IGF1 (Insulin Like Growth Factor 1), and among its related pathways/superpathways are Neuroactive ligand-receptor interaction and Thermogenesis. The drugs Liraglutide and Aluminum hydroxide, magnesium hydroxide, simethicone drug combination have been mentioned in the context of this disorder. Affiliated tissues include liver, adipocyte and brain, and related phenotype is neoplasm.

Wikipedia : 74 Like many other medical conditions, obesity is the result of an interplay between environmental and... more...

Related Diseases for Genetic Obesity

Diseases related to Genetic Obesity via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 insulin-like growth factor i 29.6 LEP IGF1
2 fatty liver disease 29.3 LEPR LEP
3 pseudohypoparathyroidism 29.2 LEP IGF1
4 hyperinsulinism 29.2 LEPR LEPQTL1 LEP IGF1
5 hypothalamic obesity 29.0 LEPR LEP IGF1
6 body mass index quantitative trait locus 11 28.8 LEPR LEPQTL1 LEP IGF1
7 hypogonadism 28.7 LEPR LEP IGF1
8 glucose intolerance 28.6 LEPR LEPQTL1 LEP IGF1
9 hypothyroidism 28.6 LEPQTL1 LEP IGF1
10 diabetes mellitus, noninsulin-dependent 28.5 LEPR LEPQTL1 LEP IGF1
11 prader-willi syndrome 28.4 LEPR LEPQTL1 LEP IGF1
12 leptin deficiency or dysfunction 28.4 LEPR LEPQTL1 LEP IGF1
13 body mass index quantitative trait locus 9 10.3
14 body mass index quantitative trait locus 8 10.3
15 body mass index quantitative trait locus 4 10.3
16 body mass index quantitative trait locus 10 10.3
17 body mass index quantitative trait locus 7 10.3
18 body mass index quantitative trait locus 12 10.3
19 body mass index quantitative trait locus 14 10.3
20 body mass index quantitative trait locus 18 10.3
21 body mass index quantitative trait locus 19 10.3
22 body mass index quantitative trait locus 20 10.3
23 hyperglycemia 10.3
24 hypertriglyceridemia, familial 10.1
25 hypercholesterolemia, familial, 1 10.1
26 pancreas disease 10.0 LEP IGF1
27 syndromic obesity 10.0 LEPR LEP
28 lipoblastoma 10.0 LEPR LEP
29 hypothalamic disease 10.0 LEP IGF1
30 aromatase excess syndrome 10.0 LEP IGF1
31 skin tag 10.0 LEP IGF1
32 intracranial hypertension, idiopathic 10.0 LEP IGF1
33 pigmentation disease 9.9 LEP IGF1
34 sex development disorder 9.9 LEP IGF1
35 persistent fetal circulation syndrome 9.9 LEP IGF1
36 adult syndrome 9.9 LEP IGF1
37 apnea, obstructive sleep 9.9 LEP IGF1
38 adrenal cortex disease 9.9 LEP IGF1
39 acanthosis nigricans 9.9 LEP IGF1
40 anovulation 9.9 LEP IGF1
41 muscle hypertrophy 9.9 LEP IGF1
42 female breast cancer 9.9 LEP IGF1
43 short bowel syndrome 9.9 LEP IGF1
44 sleep disorder 9.9 LEP IGF1
45 craniopharyngioma 9.9 LEPR IGF1
46 abetalipoproteinemia 9.9 LEP IGF1
47 abdominal obesity-metabolic syndrome 1 9.9 LEPR LEP
48 amenorrhea 9.9 LEP IGF1
49 vascular disease 9.9
50 bone resorption disease 9.9 LEP IGF1

Graphical network of the top 20 diseases related to Genetic Obesity:



Diseases related to Genetic Obesity

Symptoms & Phenotypes for Genetic Obesity

MGI Mouse Phenotypes related to Genetic Obesity:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 IGF1 LEP LEPR

Drugs & Therapeutics for Genetic Obesity

Drugs for Genetic Obesity (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Liraglutide Approved 204656-20-2 44147092
2 Aluminum hydroxide, magnesium hydroxide, simethicone drug combination
3 Protective Agents
4 Antioxidants
5 TEMPO
6 Incretins
7 Hormone Antagonists
8 Hypoglycemic Agents
9 Hormones

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Regression of Fatty Heart by Valsartan Therapy Withdrawn NCT00745953 Phase 4 Valsartan;Hydrochlorothiazide
2 The TEMPO (Tracing the Effect of the MC4 Pathway in Obesity) Registry Involving Variants in Hypothalamic Genes Upstream or Downstream From the Melanocortin-4 Receptor (MC4R) Recruiting NCT03479437
3 Vanderbilt Childhood Obesity Registry Recruiting NCT02957916
4 Implementation of a National Register of Children and Adults Presenting Prader-Willi Syndrome Recruiting NCT02829684
5 Investigation of the Metabolic Effects of 3mg Liraglutide on Patients With Overweight or Obesity Recruiting NCT03885297 Saxenda

Search NIH Clinical Center for Genetic Obesity

Genetic Tests for Genetic Obesity

Anatomical Context for Genetic Obesity

MalaCards organs/tissues related to Genetic Obesity:

40
Liver, Adipocyte, Brain, Skeletal Muscle, Heart, Pancreas, Bone

Publications for Genetic Obesity

Articles related to Genetic Obesity:

(show top 50) (show all 370)
# Title Authors PMID Year
1
Genetic Obesity and Bariatric Surgery Outcome in 1014 Patients with Morbid Obesity. 61
31650404 2020
2
Adenosine accumulation causes metabolic disorders in testes and associates with lower testosterone level in obese mice. 61
32026564 2020
3
Differential contribution of Nox1, Nox2 and Nox4 to kidney vascular oxidative stress and endothelial dysfunction in obesity. 61
31563085 2020
4
Adipocyte-specific deletion of IL-6 does not attenuate obesity-induced weight gain or glucose intolerance in mice. 61
31386565 2019
5
Mendelian non-syndromic obesity. 61
31577261 2019
6
Genetics of lipedema: new perspectives on genetic research and molecular diagnoses. 61
31298310 2019
7
A comprehensive diagnostic approach to detect underlying causes of obesity in adults. 61
30821060 2019
8
A toddler with a novel LEPR mutation. 61
30778850 2019
9
Association between genetic obesity susceptibility and mother-reported eating behaviour in children up to 5 years. 61
30702799 2019
10
Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells. 61
30819824 2019
11
Insights into the Allosteric Mechanism of Setmelanotide (RM-493) as a Potent and First-in-Class Melanocortin-4 Receptor (MC4R) Agonist To Treat Rare Genetic Disorders of Obesity through an in Silico Approach. 61
30048591 2019
12
Tracing the effect of the melanocortin-4 receptor pathway in obesity: study design and methodology of the TEMPO registry. 61
31239751 2019
13
Genetics of Obesity. 61
31588542 2019
14
Extensive Phenotyping for Potential Weight-Inducing Factors in an Outpatient Population with Obesity. 61
31216558 2019
15
Increased brain age in adults with Prader-Willi syndrome. 61
30658944 2019
16
Hippocampal brain-derived neurotrophic factor determines recruitment of anatomically connected networks after stress in diabetic mice. 61
30098276 2018
17
ROHHAD Syndrome, a Rare Cause of Hypothalamic Obesity: Report of Two Cases 61
29553042 2018
18
Genetic obesity: next-generation sequencing results of 1230 patients with obesity. 61
29970488 2018
19
p53 Functions in Adipose Tissue Metabolism and Homeostasis. 61
30181511 2018
20
Finding treatable genetic obesity: strategies for success. 61
29771759 2018
21
Obesity-induced overexpression of miRNA-24 regulates cholesterol uptake and lipid metabolism by targeting SR-B1. 61
29787826 2018
22
Discovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model. 61
29699923 2018
23
Enoyl coenzyme A hydratase 1 protects against high-fat-diet-induced hepatic steatosis and insulin resistance. 61
29526751 2018
24
Genetic factors in sleep-disordered breathing. 61
29548648 2018
25
A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome. 61
29590610 2018
26
Effects of a combined intervention with a lentil protein hydrolysate and a mixed training protocol on the lipid metabolism and hepatic markers of NAFLD in Zucker rats. 61
29364302 2018
27
Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in ob/ob Mice. 61
30123267 2018
28
Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet. 61
30079055 2018
29
Pyruvate induces torpor in obese mice. 61
29311303 2018
30
Metabolic biomarkers and gallstone disease - a population-based study. 61
28799434 2017
31
FTO genotype and weight status among preadolescents: Assessing the mediating effects of obesogenic appetitive traits. 61
28712975 2017
32
Dietary effects of Raphanus sativus cv Sango on lipid and oxysterols accumulation in rat brain: A lipidomic study on a non-genetic obesity model. 61
28539223 2017
33
Engineering brown fat into skeletal muscle using ultrasound-targeted microbubble destruction gene delivery in obese Zucker rats: Proof of concept design. 61
28762248 2017
34
Long-term effects of bariatric surgery in patients with obesity and chromosome 16 p11.2 microdeletion. 61
28600117 2017
35
Obesity-induced discrepancy between contractile and metabolic phenotypes in slow- and fast-twitch skeletal muscles of female obese Zucker rats. 61
28522764 2017
36
Response by Chatterjee et al to Letter Regarding Article, "Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates From Mendelian Randomization". 61
28739818 2017
37
Letter by Koh Regarding Article, "Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization". 61
28739817 2017
38
Genetic Obesity Risk and Attenuation Effect of Physical Fitness in Mexican-Mestizo Population: a Case-Control Study. 61
28294290 2017
39
High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism. 61
27940965 2017
40
Obesity-induced endoplasmic reticulum stress suppresses nuclear factor-Y expression. 61
27837431 2017
41
Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization. 61
27974350 2017
42
[Genetic obesity: new diagnostic options]. 61
28351432 2017
43
Interactome of Obesity: Obesidome : Genetic Obesity, Stress Induced Obesity, Pathogenic Obesity Interaction. 61
28971462 2017
44
A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats. 61
28132653 2017
45
Deactivation of the left dorsolateral prefrontal cortex in Prader-Willi syndrome after meal consumption. 61
27121248 2016
46
Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism. 61
27822554 2016
47
FADD is a key regulator of lipid metabolism. 61
27357657 2016
48
Effects of pterostilbene in brown adipose tissue from obese rats. 61
28243863 2016
49
Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis. 61
26860405 2016
50
Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice. 61
26860833 2016

Variations for Genetic Obesity

Expression for Genetic Obesity

Search GEO for disease gene expression data for Genetic Obesity.

Pathways for Genetic Obesity

Pathways related to Genetic Obesity according to KEGG:

36
# Name Kegg Source Accession
1 Neuroactive ligand-receptor interaction hsa04080
2 Thermogenesis hsa04714
3 Regulation of lipolysis in adipocytes hsa04923
4 PPAR signaling pathway hsa03320

GO Terms for Genetic Obesity

Biological processes related to Genetic Obesity according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 glucose homeostasis GO:0042593 9.55 LEPR LEP
2 positive regulation of MAPK cascade GO:0043410 9.54 LEP IGF1
3 cholesterol metabolic process GO:0008203 9.52 LEPR LEP
4 positive regulation of cold-induced thermogenesis GO:0120162 9.51 LEPR LEP
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.49 LEP IGF1
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.48 LEP IGF1
7 phagocytosis GO:0006909 9.46 LEPR LEP
8 negative regulation of autophagy GO:0010507 9.43 LEPR LEP
9 T cell differentiation GO:0030217 9.4 LEPR LEP
10 energy reserve metabolic process GO:0006112 9.37 LEPR LEP
11 sexual reproduction GO:0019953 9.32 LEPR LEP
12 leptin-mediated signaling pathway GO:0033210 9.26 LEPR LEP
13 regulation of bone remodeling GO:0046850 9.16 LEPR LEP
14 bone mineralization involved in bone maturation GO:0035630 8.96 LEP IGF1
15 bone growth GO:0098868 8.62 LEPR LEP

Molecular functions related to Genetic Obesity according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 LEP IGF1

Sources for Genetic Obesity

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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