MCID: GNC005
MIFTS: 29

Geniculate Ganglionitis

Categories: Neuronal diseases

Aliases & Classifications for Geniculate Ganglionitis

MalaCards integrated aliases for Geniculate Ganglionitis:

Name: Geniculate Ganglionitis 12 15 70 32
Facial Nerve Diseases 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:14075
ICD9CM 34 351.1
MeSH 44 D005155
SNOMED-CT 67 155071009
ICD10 32 G51.1
UMLS 70 C0015464 C0017407

Summaries for Geniculate Ganglionitis

MalaCards based summary : Geniculate Ganglionitis, also known as facial nerve diseases, is related to herpes zoster and herpes zoster oticus, and has symptoms including oral manifestations, facial paresis and numbness along 7th cranial nerve. An important gene associated with Geniculate Ganglionitis is IFNA2 (Interferon Alpha 2), and among its related pathways/superpathways are Human cytomegalovirus infection and Allograft rejection. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include eye and skin.

Wikipedia : 73 Geniculate ganglionitis or geniculate neuralgia (GN), also called nervus intermedius neuralgia, Ramsay... more...

Related Diseases for Geniculate Ganglionitis

Diseases related to Geniculate Ganglionitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 herpes zoster 29.7 IFNA2 CD4
2 herpes zoster oticus 11.3
3 facial nerve disease 11.2
4 follicular mucinosis 9.8 IFNA2 CD4
5 rhinosporidiosis 9.8 IFNA2 CD4
6 parasitic ichthyosporea infectious disease 9.8 IFNA2 CD4
7 autoimmune cholangitis 9.8 IFNA2 CD4
8 anogenital venereal wart 9.8 IFNA2 CD4
9 penile disease 9.8 IFNA2 CD4
10 conjunctival disease 9.8 IFNA2 CD4
11 dysentery 9.8 IFNA2 CD4
12 panuveitis 9.8 IFNA2 CD4
13 thrombocytopenic purpura, autoimmune 9.8 IFNA2 CD4
14 common cold 9.8 IFNA2 CD4
15 stomatitis 9.7 IFNA2 CD4
16 sezary's disease 9.7 IFNA2 CD4
17 acquired immunodeficiency syndrome 9.7 IFNA2 CD4
18 viral infectious disease 9.7 IFNA2 CD4
19 behcet syndrome 9.7 IFNA2 CD4
20 skin melanoma 9.6 IFNA2 CD4
21 deficiency anemia 9.6 IFNA2 CD4
22 skin carcinoma 9.5 IFNA2 CD4

Comorbidity relations with Geniculate Ganglionitis via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Geniculate Ganglionitis:



Diseases related to Geniculate Ganglionitis

Symptoms & Phenotypes for Geniculate Ganglionitis

UMLS symptoms related to Geniculate Ganglionitis:


oral manifestations; facial paresis; numbness along 7th cranial nerve

Drugs & Therapeutics for Geniculate Ganglionitis

Drugs for Geniculate Ganglionitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
7
Cortisone Experimental Phase 4 53-06-5 222786
8 Hormones Phase 4
9 Methylprednisolone Acetate Phase 4
10 Hormone Antagonists Phase 4
11 glucocorticoids Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 Anti-Inflammatory Agents Phase 4
14
Prednisone Approved, Vet_approved 53-03-2 5865
15
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
16
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
17
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
18
Clotrimazole Approved, Vet_approved 23593-75-1 2812
19
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
20
Lidocaine Approved, Vet_approved 137-58-6 3676
21
Prilocaine Approved 721-50-6 4906
22
tannic acid Approved 1401-55-4
23
Gabapentin Approved, Investigational 60142-96-3 3446
24
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
25
Lamotrigine Approved, Investigational 84057-84-1 3878
26 Gastrointestinal Agents
27 Antiemetics
28 Pharmaceutical Solutions
29 Anti-Infective Agents
30 Antifungal Agents
31 Dermatologic Agents
32 Keratolytic Agents
33 insulin
34 Insulin, Globin Zinc
35 Psychotropic Drugs
36 Sodium Channel Blockers
37 Anticonvulsants
38 Diuretics, Potassium Sparing
39 calcium channel blockers
40 Antipsychotic Agents
41 Calcium, Dietary
42
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Facial Nerve Palsy And Cortisone Evaluation (FACE) Study in Children: A Randomized Double-blind, Placebo-controlled, Multicenter Trial Recruiting NCT03781700 Phase 4 Prednisolone;Placebo Oral Tablet
2 Mimetic Interfaces - Toispuoleisen Kasvohermohalvauksen Kojeellinen Kuntoutus Terveen Puolen Lihasaktiviteettiohjauksella. Stimulaattorin Prototyypin Testaus terveillä koehenkilöillä ja Kasvohermohalvauspotilailla. Active, not recruiting NCT03496025 Phase 1
3 Imaging of Facial Neuritis Using T2-weighted Gradient-echo Fast Imaging Employing Steady State Acquisition After Gadolinium Injection Unknown status NCT03543384
4 Prednisone Acetate and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, Comparative Effectiveness Research in China Unknown status NCT01201642 Prednisolone
5 Intratympanic Stereoidal Injections for Facial Nerve Palsy Unknown status NCT03371589 Dexamethasone
6 The Role of MyotonPro in Assessing the Biomechanical Properties of Facial Muscles in Facial Paralysis Patients and Its Role in Monitoring Recovery Following Facial Reanimation Surgery Completed NCT02489162
7 Neuro Occlusal Rehabilitation in Patient With Peripheral Facial Paralysis - a Randomized Clinical Trial Completed NCT01327157
8 The Role of Collagen in the Rehabilitation of Peripheral Paralysis of the Facial Nerve Completed NCT04353908
9 Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI Completed NCT00243152 Lamotrigine;Placebo (for Lamotrigine)

Search NIH Clinical Center for Geniculate Ganglionitis

Cochrane evidence based reviews: facial nerve diseases

Genetic Tests for Geniculate Ganglionitis

Anatomical Context for Geniculate Ganglionitis

MalaCards organs/tissues related to Geniculate Ganglionitis:

40
Eye, Skin

Publications for Geniculate Ganglionitis

Articles related to Geniculate Ganglionitis:

(show all 15)
# Title Authors PMID Year
1
Facial nerve electrodiagnostics for patients with facial palsy: a clinical practice guideline. 61
32270328 2020
2
Ramsay Hunt syndrome associated with solitary nucleus, spinal trigeminal nucleus and tract, and vestibular nucleus involvement on sequential magnetic resonance imaging. 61
30168017 2018
3
[The progress of glucocorticoids via postauricular injection in treatment of sudden hearing loss]. 61
29871146 2016
4
Reference values for dynamic facial muscle ultrasonography in adults. 61
24519557 2014
5
[Anomaly of infrared thermal radiation intensity on unilateral mild to moderate Bell's palsy]. 61
21800579 2011
6
Features of facial asymmetry following incomplete recovery from facial paralysis. 61
20879064 2010
7
[Electrophysiological examination of the cranial nerves: technical aspects and practical applications]. 61
15244162 2004
8
Cortical representation of the orbicularis oculi muscle as assessed by transcranial magnetic stimulation (TMS). 61
11801987 2001
9
[The normal value and clinical applications of the blink reflex]. 61
11938846 1998
10
Molecular temporal bone pathology: II. Ramsay Hunt syndrome (herpes zoster oticus). 61
9292598 1997
11
Medical management of idiopathic (Bell's) palsy. 61
1762782 1991
12
[An experimental study of herpes simplex virus infection in the facial nerve]. 61
2553903 1989
13
[Intratemporal course of the facial nerve in magnetic resonance imaging]. 61
2917878 1989
14
Neuromyography in the diagnostics of Bell's palsy. 61
6475422 1984
15
Herpes zoster auris (geniculate ganglionitis). 61
21012403 1945

Variations for Geniculate Ganglionitis

Expression for Geniculate Ganglionitis

Search GEO for disease gene expression data for Geniculate Ganglionitis.

Pathways for Geniculate Ganglionitis

GO Terms for Geniculate Ganglionitis

Biological processes related to Geniculate Ganglionitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.26 IFNA2 CD4
2 adaptive immune response GO:0002250 9.16 IFNA2 CD4
3 cell surface receptor signaling pathway GO:0007166 8.96 IFNA2 CD4
4 cytokine-mediated signaling pathway GO:0019221 8.62 IFNA2 CD4

Sources for Geniculate Ganglionitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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