MCID: GNC003
MIFTS: 38

Geniculate Herpes Zoster

Categories: Ear diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Geniculate Herpes Zoster

MalaCards integrated aliases for Geniculate Herpes Zoster:

Name: Geniculate Herpes Zoster 12 15
Herpes Zoster Oticus 12 76 53 54 44 73
Nervus Intermedius Neuralgia 12 53 73
Geniculate Neuralgia 12 53
Facial Nerve Palsy Due to Herpes Zoster Infection 53
Facial Nerve Paralysis Due to Vzv 53
Herpetic Geniculate Ganglionitis 12
Facial Nerve Palsy Due to Vzv 53
Ramsay Hunt Syndrome Type Ii 12
Ramsay Hunt Syndrome Type 2 12
Herpes Zoster Auricularis 12
Ramsay Hunt Syndrome Ii 54
Myoclonus and Ataxia 73
Ramsay Hunt Syndrome 53
Ramsey Hunt Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9210
ICD10 33 B02.21
ICD9CM 35 053.11
MeSH 44 D016697
NCIt 50 C84763
SNOMED-CT 68 21954000

Summaries for Geniculate Herpes Zoster

NIH Rare Diseases : 53 Herpes zoster oticus is a common complication of shingles, an infection caused by the varicella-zoster virus (which is the virus that also causes chickenpox). Shingles occurs in people who have had chickenpox and in whom the varicella-zoster virus becomes active again. Herpes zoster oticus is caused by the spread of the virus to facial nerves and can cause intense ear pain; a rash around the ear, mouth, face, neck, and scalp; and paralysis of the face. Other symptoms may include hearing loss, vertigo (feeling that the room is spinning), tinnitus (hearing abnormal sounds), nausea, vomiting, loss of taste in the tongue, and dry mouth and eyes. Some cases of herpes zoster oticus do not require treatment, but when treatment is needed, pain medications, antiviral drugs or corticosteroids may be prescribed. Vertigo is sometimes treated with medication as well. The prognosis of herpes zoster oticus is typically good, but in some cases hearing loss or facial paralysis may be permanent. 

MalaCards based summary : Geniculate Herpes Zoster, also known as herpes zoster oticus, is related to ramsay hunt syndrome i and myoclonus and ataxia, and has symptoms including vertigo, headache and tinnitus. An important gene associated with Geniculate Herpes Zoster is MT-TC (Mitochondrially Encoded TRNA Cysteine). The drugs Cladribine and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include eye, tongue and testes.

Disease Ontology : 12 A viral infectious disease that results in inflammation located in facial nerve, which leads to paralysis of one side of the face, has material basis in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has symptom vesicular rash of the ear or mouth, has symptom tinnitus, has symptom vertigo, has symptom otalgia, and has symptom headache.

NINDS : 54 Herpes zoster oticus, also called Ramsay Hunt Syndrome or Ramsay Hunt Syndrome type II, is a common complication of shingles. Shingles is an infection caused by the varicella-zoster virus, which is the virus that causes chickenpox. Shingles occurs in people who have had chickenpox and represents a reactivation of the dormant varicella-zoster virus. Herpes zoster oticus, which is caused by the spread of the varicella-zoster virus to facial nerves, is characterized by intense ear pain, a rash around the ear, mouth, face, neck, and scalp, and paralysis of facial nerves. Other symptoms may include hearing loss, vertigo (abnormal sensation of movement), and tinnitus (abnormal sounds). Taste loss in the tongue and dry mouth and eyes may also occur.

Wikipedia : 76 Ramsay Hunt syndrome type 2, also known as herpes zoster oticus, is a disorder that is caused by the... more...

Related Diseases for Geniculate Herpes Zoster

Diseases related to Geniculate Herpes Zoster via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 ramsay hunt syndrome i 12.6
2 myoclonus and ataxia 12.4
3 geniculate ganglionitis 11.3
4 herpes zoster 10.7
5 bell's palsy 10.6
6 myoclonus 10.5
7 polyneuropathy 10.5
8 facial paralysis 10.5
9 viral infectious disease 10.4
10 encephalitis 10.4
11 occipital neuralgia 10.3
12 headache 10.3
13 acoustic neuroma 10.3
14 neuritis 10.3
15 epilepsy 10.3
16 neuroma 10.3
17 laryngitis 10.3
18 meningitis 10.3
19 dysphagia 10.3
20 rheumatoid arthritis 10.2
21 lung cancer 10.2
22 arthritis 10.2
23 osteonecrosis 10.2
24 lymphocytic leukemia 10.2
25 chickenpox 10.2
26 optic nerve disease 10.1
27 leukemia, chronic lymphocytic 2 10.0
28 dentatorubral-pallidoluysian atrophy 10.0
29 leukemia, chronic lymphocytic 10.0
30 mitochondrial myopathy 10.0
31 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.0
32 stroke, ischemic 10.0
33 focal segmental glomerulosclerosis 1 10.0
34 leukemia, acute lymphoblastic 10.0
35 crohn's disease 10.0
36 diabetes mellitus 10.0
37 focal segmental glomerulosclerosis 10.0
38 leukemia 10.0
39 atrial fibrillation 10.0
40 osteomyelitis 10.0
41 petrositis 10.0
42 gastroparesis 10.0
43 aseptic meningitis 10.0
44 brain stem infarction 10.0
45 myopathy 10.0
46 infertility 10.0
47 human immunodeficiency virus infectious disease 10.0
48 influenza 10.0
49 herpes simplex 10.0
50 neuropathy 10.0

Graphical network of the top 20 diseases related to Geniculate Herpes Zoster:



Diseases related to Geniculate Herpes Zoster

Symptoms & Phenotypes for Geniculate Herpes Zoster

Symptoms:

12
  • vertigo
  • headache
  • tinnitus
  • vesicular rash of the ear or mouth
  • otalgia

UMLS symptoms related to Geniculate Herpes Zoster:


earache, neuralgia

Drugs & Therapeutics for Geniculate Herpes Zoster

Drugs for Geniculate Herpes Zoster (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cladribine Approved, Investigational Phase 3 4291-63-8 20279
2 Immunologic Factors Phase 3
3 Immunosuppressive Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 CLARITY Extension Study Completed NCT00641537 Phase 3 Cladribine;Placebo;Cladribine;Cladribine;Placebo
2 Transcranial Magnetic Stimulation for Facial Pain Active, not recruiting NCT02633306 Not Applicable

Search NIH Clinical Center for Geniculate Herpes Zoster

Cochrane evidence based reviews: herpes zoster oticus

Genetic Tests for Geniculate Herpes Zoster

Anatomical Context for Geniculate Herpes Zoster

MalaCards organs/tissues related to Geniculate Herpes Zoster:

41
Eye, Tongue, Testes, Brain, Bone, Lung, B Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Geniculate Herpes Zoster:

19
Facial Nerve

Publications for Geniculate Herpes Zoster

Articles related to Geniculate Herpes Zoster:

(show top 50) (show all 56)
# Title Authors Year
1
Characteristics of hearing loss in patients with herpes zoster oticus. ( 27861389 )
2016
2
Clinical manifestations in patients with herpes zoster oticus. ( 26308524 )
2016
3
Test Battery of Cranial Nerves VII and VIII for Assessing Herpes Zoster Oticus. ( 25385809 )
2014
4
A case of generalized varicelliform eruption after herpes zoster oticus. ( 24335939 )
2014
5
Painful rash of the auricle: Herpes zoster oticus. ( 25531857 )
2014
6
Herpes zoster oticus: a clinical model for a transynaptic, reflex pathways, viral transmission hypotheses. ( 22709534 )
2012
7
Herpes zoster oticus (Ramsay Hunt syndrome) in children: case report and literature review. ( 22445801 )
2012
8
Prognostic factors in herpes zoster oticus (ramsay hunt syndrome). ( 21725270 )
2011
9
Herpes zoster oticus: A rare clinical entity. ( 22114399 )
2010
10
Correlation between enhanced MRI and surgical findings in herpes zoster oticus. ( 18836966 )
2009
11
Herpes zoster oticus associated with varicella zoster virus encephalitis. ( 19213041 )
2009
12
Corticosteroids as adjuvant to antiviral treatment in Ramsay Hunt syndrome (herpes zoster oticus with facial palsy) in adults. ( 18646170 )
2008
13
Antiviral therapy for Ramsay Hunt syndrome (herpes zoster oticus with facial palsy) in adults. ( 18843734 )
2008
14
Statistical analysis of pure tone audiometry and caloric test in herpes zoster oticus. ( 19434256 )
2008
15
Vertigo from herpes zoster oticus: superior or inferior vestibular nerve origin? ( 12567087 )
2003
16
Bell's Palsy and Herpes Zoster Oticus. ( 11096766 )
2000
17
Herpes zoster oticus with pontine lesion: segmental brain-stem encephalitis. ( 10619773 )
2000
18
Herpes zoster oticus treated with acyclovir and prednisolone: clinical manifestations and analysis of prognostic factors. ( 10816219 )
2000
19
Herpes zoster oticus following mandibular block. ( 10829113 )
2000
20
Herpes zoster oticus: correlations between clinical and MRI findings. ( 9476720 )
1998
21
Molecular temporal bone pathology: II. Ramsay Hunt syndrome (herpes zoster oticus). ( 9292598 )
1997
22
Facial weakness and rash. Ramsay Hunt syndrome (herpes zoster cephalicus, herpes zoster oticus, herpes zoster auricularis). ( 8959171 )
1996
23
Pathologic quiz case 2. Bilateral herpes zoster oticus. ( 8630216 )
1996
24
Impaired specific cellular immunity to the varicella-zoster virus in patients with herpes zoster oticus. ( 8977852 )
1996
25
[Epidemic outbreak of herpes zoster oticus (Ramsay-Hunt syndrome)]. ( 7573854 )
1995
26
Gd-DPTA enhanced MRI in Bell's palsy and herpes zoster oticus: an overview and implications for future studies. ( 8928627 )
1995
27
Herpes zoster oticus: diagnosis and management. ( 8228542 )
1993
28
Herpes zoster oticus-diagnosis and treatment. ( 1399478 )
1992
29
Herpes zoster oticus associated with facial, auditory and trigeminal involvement. ( 1634465 )
1992
30
Herpes zoster oticus: treatment with acyclovir. ( 1739262 )
1992
31
Gadolinium-enhanced magnetic resonance imaging of the facial nerve in herpes zoster oticus and Bell's palsy: clinical implications. ( 1882962 )
1991
32
Herpes zoster oticus. ( 2058599 )
1991
33
Herpes zoster oticus: treatment with intravenous acyclovir. ( 3386386 )
1988
34
Acyclovir in herpes zoster oticus. ( 2860316 )
1985
35
Pathological findings and surgical implications in herpes zoster oticus. ( 6624594 )
1983
36
Herpes zoster oticus: surgery based upon prognostic indicators and results. ( 7162299 )
1982
37
Herpes zoster oticus. Uncommon but recognizable cause of facial paralysis. ( 424347 )
1979
38
Optic neuropathy and ophthalmoplegia in herpes zoster oticus. ( 312472 )
1979
39
Acute vestibular paralysis in herpes zoster oticus. ( 313735 )
1979
40
Red chorda tympani nerve in Herpes Zoster oticus. ( 966922 )
1976
41
Herpes zoster oticus and facial paralysis. ( 4600185 )
1974
42
Herpes zoster oticus: report of a case. ( 4496990 )
1974
43
Herpes zoster oticus and facial paralysis (Ramsay Hunt syndrome). Clinico-pathologic study and review of literature. ( 4750874 )
1973
44
5-HIAA and HVA in spinal fluid and herpes zoster oticus. ( 5563972 )
1971
45
Herpes zoster oticus. ( 5486960 )
1970
46
Herpes zoster oticus. ( 4881774 )
1968
47
Geniculate ganglion syndrome (Hunt's syndrome, Herpes zoster oticus). ( 5636504 )
1968
48
Observation on herpes zoster oticus & laryngs. ( 5831547 )
1965
49
CHICKENPOX AND HERPES ZOSTER OTICUS. ( 14064160 )
1963
50
Histopathology of the facial nerve in herpes zoster oticus. ( 13626314 )
1959

Variations for Geniculate Herpes Zoster

Expression for Geniculate Herpes Zoster

Search GEO for disease gene expression data for Geniculate Herpes Zoster.

Pathways for Geniculate Herpes Zoster

GO Terms for Geniculate Herpes Zoster

Biological processes related to Geniculate Herpes Zoster according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.62 HP SERPINA1

Molecular functions related to Geniculate Herpes Zoster according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 SERPINA1 TNFRSF10A

Sources for Geniculate Herpes Zoster

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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