MCID: GNC003
MIFTS: 40

Geniculate Herpes Zoster

Categories: Rare diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Geniculate Herpes Zoster

MalaCards integrated aliases for Geniculate Herpes Zoster:

Name: Geniculate Herpes Zoster 12 15
Herpes Zoster Oticus 12 76 53 54 44 73
Nervus Intermedius Neuralgia 12 53 73
Geniculate Neuralgia 12 53
Facial Nerve Palsy Due to Herpes Zoster Infection 53
Facial Nerve Paralysis Due to Vzv 53
Herpetic Geniculate Ganglionitis 12
Facial Nerve Palsy Due to Vzv 53
Ramsay Hunt Syndrome Type Ii 12
Ramsay Hunt Syndrome Type 2 12
Herpes Zoster Auricularis 12
Ramsay Hunt Syndrome Ii 54
Myoclonus and Ataxia 73
Ramsay Hunt Syndrome 53
Ramsey Hunt Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9210
ICD10 33 B02.21
ICD9CM 35 053.11
MeSH 44 D016697
NCIt 50 C84763

Summaries for Geniculate Herpes Zoster

NIH Rare Diseases : 53 Herpes zoster oticus is a common complication of shingles, an infection caused by the varicella-zoster virus (which is the virus that also causes chickenpox). Shingles occurs in people who have had chickenpox and in whom the varicella-zoster virus becomes active again. Herpes zoster oticus is caused by the spread of the virus to facial nerves and can cause intense ear pain; a rash around the ear, mouth, face, neck, and scalp; and paralysis of the face. Other symptoms may include hearing loss, vertigo (feeling that the room is spinning), tinnitus (hearing abnormal sounds), nausea, vomiting, loss of taste in the tongue, and dry mouth and eyes. Some cases of herpes zoster oticus do not require treatment, but when treatment is needed, pain medications, antiviral drugs or corticosteroids may be prescribed. Vertigo is sometimes treated with medication as well. The prognosis of herpes zoster oticus is typically good, but in some cases hearing loss or facial paralysis may be permanent. 

MalaCards based summary : Geniculate Herpes Zoster, also known as herpes zoster oticus, is related to neuronitis and chickenpox, and has symptoms including vesicular rash of the ear or mouth, tinnitus and vertigo. An important gene associated with Geniculate Herpes Zoster is MT-TC (Mitochondrially Encoded TRNA Cysteine), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Cladribine and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include facial nerve, eye and tongue.

Disease Ontology : 12 A viral infectious disease that results in inflammation located in facial nerve, which leads to paralysis of one side of the face, has material basis in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has symptom vesicular rash of the ear or mouth, has symptom tinnitus, has symptom vertigo, has symptom otalgia, and has symptom headache.

NINDS : 54 Herpes zoster oticus, also called Ramsay Hunt Syndrome or Ramsay Hunt Syndrome type II, is a common complication of shingles. Shingles is an infection caused by the varicella-zoster virus, which is the virus that causes chickenpox. Shingles occurs in people who have had chickenpox and represents a reactivation of the dormant varicella-zoster virus. Herpes zoster oticus, which is caused by the spread of the varicella-zoster virus to facial nerves, is characterized by intense ear pain, a rash around the ear, mouth, face, neck, and scalp, and paralysis of facial nerves. Other symptoms may include hearing loss, vertigo (abnormal sensation of movement), and tinnitus (abnormal sounds). Taste loss in the tongue and dry mouth and eyes may also occur.

Wikipedia : 76 Ramsay Hunt syndrome type 2, also known as herpes zoster oticus, is a disorder that is caused by the... more...

Related Diseases for Geniculate Herpes Zoster

Diseases related to Geniculate Herpes Zoster via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)
# Related Disease Score Top Affiliating Genes
1 neuronitis 30.6 CD40LG TNFRSF10A
2 chickenpox 30.3 CD40LG CD79A
3 ramsay hunt syndrome i 12.4
4 myoclonus and ataxia 11.8
5 geniculate ganglionitis 11.5
6 myasthenic syndrome, congenital, 10 10.6 CD40LG MT-TC
7 evans' syndrome 10.5 CD40LG HP
8 herpes zoster 10.5
9 trench fever 10.5 CD40LG KANTR
10 japanese spotted fever 10.5 CD40LG KANTR
11 facial hemiatrophy 10.5 CD40LG KANTR
12 brachial plexus neuritis 10.5 CD40LG KANTR
13 central nervous system vasculitis 10.4 CD40LG TNFRSF10A
14 intracranial vasospasm 10.4 HP KANTR
15 facial nerve disease 10.4 CD40LG KANTR
16 bell's palsy 10.4
17 functional colonic disease 10.4 CD40LG KANTR
18 dirofilariasis 10.4 CD40LG HP
19 selective igg deficiency disease 10.4 CD40LG CD79A
20 branch retinal artery occlusion 10.4 CD40LG KANTR
21 c1q nephropathy 10.4 CD40LG CD79A
22 rheumatic fever 10.4 CD40LG HP
23 meningovascular neurosyphilis 10.4 CD40LG CD79A
24 alpha chain disease 10.4 CD40LG CD79A
25 brill-zinsser disease 10.4 CD40LG CD79A
26 exudative glomerulonephritis 10.4 CD40LG CD79A
27 cork-handlers' disease 10.4 CD40LG CD79A
28 salpingo-oophoritis 10.4 CD40LG CD79A
29 early yaws 10.4 CD40LG CD79A
30 ventilation pneumonitis 10.4 CD40LG CD79A
31 chronic interstitial cystitis 10.4 CD40LG CD79A
32 axillary adenitis 10.4 CD40LG CD79A
33 myoclonus 10.4
34 trichostrongyloidiasis 10.4 CD40LG CD79A
35 subacute bacterial endocarditis 10.4 CD40LG CD79A
36 heterophyiasis 10.4 CD40LG CD79A
37 immunoglobulin g deficiency 10.4 CD40LG CD79A
38 orbital granuloma 10.4 CD40LG CD79A
39 transient hypogammaglobulinemia of infancy 10.4 CD40LG CD79A
40 hyperglobulinemic purpura 10.4 CD40LG CD79A
41 gastroduodenitis 10.4 CD40LG CD79A
42 bacterial conjunctivitis 10.4 CD40LG CD79A
43 heavy chain disease 10.4 CD40LG CD79A
44 ophthalmia neonatorum 10.4 CD40LG CD79A
45 immunoglobulin a deficiency 1 10.4 CD40LG CD79A
46 parotid disease 10.4 CD40LG CD79A
47 selective immunoglobulin deficiency disease 10.4 CD40LG CD79A
48 neuroretinitis 10.4 CD40LG TNFRSF10A
49 erythema elevatum diutinum 10.4 CD40LG CD79A
50 sporotrichosis 10.4 CD40LG CD79A

Graphical network of the top 20 diseases related to Geniculate Herpes Zoster:



Diseases related to Geniculate Herpes Zoster

Symptoms & Phenotypes for Geniculate Herpes Zoster

Symptoms:

12
  • vesicular rash of the ear or mouth
  • tinnitus
  • vertigo
  • otalgia
  • headache

UMLS symptoms related to Geniculate Herpes Zoster:


earache, neuralgia

Drugs & Therapeutics for Geniculate Herpes Zoster

Drugs for Geniculate Herpes Zoster (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cladribine Approved, Investigational Phase 3 4291-63-8 20279
2 Immunosuppressive Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 CLARITY Extension Study Completed NCT00641537 Phase 3 Cladribine;Placebo;Cladribine;Cladribine;Placebo
2 Transcranial Magnetic Stimulation for Facial Pain Active, not recruiting NCT02633306 Not Applicable

Search NIH Clinical Center for Geniculate Herpes Zoster

Cochrane evidence based reviews: herpes zoster oticus

Genetic Tests for Geniculate Herpes Zoster

Anatomical Context for Geniculate Herpes Zoster

The Foundational Model of Anatomy Ontology organs/tissues related to Geniculate Herpes Zoster:

19
Facial Nerve

MalaCards organs/tissues related to Geniculate Herpes Zoster:

41
Eye, Tongue, Bone, Testes

Publications for Geniculate Herpes Zoster

Articles related to Geniculate Herpes Zoster:

(show all 15)
# Title Authors Year
1
Test Battery of Cranial Nerves VII and VIII for Assessing Herpes Zoster Oticus. ( 25385809 )
2014
2
A case of generalized varicelliform eruption after herpes zoster oticus. ( 24335939 )
2014
3
Herpes zoster oticus: a clinical model for a transynaptic, reflex pathways, viral transmission hypotheses. ( 22709534 )
2012
4
Herpes zoster oticus (Ramsay Hunt syndrome) in children: case report and literature review. ( 22445801 )
2012
5
Prognostic factors in herpes zoster oticus (ramsay hunt syndrome). ( 21725270 )
2011
6
Herpes zoster oticus: A rare clinical entity. ( 22114399 )
2010
7
Corticosteroids as adjuvant to antiviral treatment in Ramsay Hunt syndrome (herpes zoster oticus with facial palsy) in adults. ( 18646170 )
2008
8
Antiviral therapy for Ramsay Hunt syndrome (herpes zoster oticus with facial palsy) in adults. ( 18843734 )
2008
9
Molecular temporal bone pathology: II. Ramsay Hunt syndrome (herpes zoster oticus). ( 9292598 )
1997
10
Facial weakness and rash. Ramsay Hunt syndrome (herpes zoster cephalicus, herpes zoster oticus, herpes zoster auricularis). ( 8959171 )
1996
11
[Epidemic outbreak of herpes zoster oticus (Ramsay-Hunt syndrome)]. ( 7573854 )
1995
12
Gd-DPTA enhanced MRI in Bell's palsy and herpes zoster oticus: an overview and implications for future studies. ( 8928627 )
1995
13
Gadolinium-enhanced magnetic resonance imaging of the facial nerve in herpes zoster oticus and Bell's palsy: clinical implications. ( 1882962 )
1991
14
Herpes zoster oticus and facial paralysis (Ramsay Hunt syndrome). Clinico-pathologic study and review of literature. ( 4750874 )
1973
15
Herpes zoster oticus; Ramsay Hunt syndrome; report of a case. ( 18113035 )
1949

Variations for Geniculate Herpes Zoster

Expression for Geniculate Herpes Zoster

Search GEO for disease gene expression data for Geniculate Herpes Zoster.

Pathways for Geniculate Herpes Zoster

Pathways related to Geniculate Herpes Zoster according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Geniculate Herpes Zoster

Biological processes related to Geniculate Herpes Zoster according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.96 HP SERPINA1
2 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for Geniculate Herpes Zoster

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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