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MCID: GNT003
MIFTS: 59

Genital Herpes

Categories: Immune diseases, Infectious diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Genital Herpes

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MalaCards integrated aliases for Genital Herpes:

Name: Genital Herpes 12 55 43 3 15 63 73
Herpes Genitalis 12 44
Genital Herpes Simplex 12
Virus-Genital Herpes 12
Herpes Genitalia 12
Venereal Herpes 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Immune diseases Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8704
ICD9CM 35 054.1 054.10
MeSH 44 D006558
NCIt 50 C14364
SNOMED-CT 68 33839006
UMLS 73 C0019342
Sources

Summaries for Genital Herpes

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MedlinePlus : 43 Genital herpes is a sexually transmitted disease (STD) caused by a herpes simplex virus (HSV). It can cause sores on your genital or rectal area, buttocks, and thighs. You can get it from having vaginal, anal, or oral sex with someone who has it. The virus can spread even when sores are not present. Mothers can also infect their babies during childbirth. Symptoms of herpes are called outbreaks. You usually get sores near the area where the virus has entered the body. The sores are blisters which break and become painful, and then heal. Sometimes people do not know they have herpes because they have no symptoms or very mild symptoms. The virus can be more serious in newborn babies or in people with weak immune systems. Repeat outbreaks are common, especially during the first year. Over time, you get them less often and the symptoms become milder. The virus stays in your body for life. There are tests that can diagnose genital herpes. There is no cure. However, medicines can help lessen symptoms, decrease outbreaks, and lower the risk of passing the virus to others. Correct usage of latex condoms can reduce, but not eliminate, the risk of catching or spreading herpes. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex.

MalaCards based summary : Genital Herpes, also known as herpes genitalis, is related to viral infectious disease and meningitis, and has symptoms including fever, sores and swollen gl. An important gene associated with Genital Herpes is ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)), and among its related pathways/superpathways are Akt Signaling and Toll-like Receptor Signaling Pathway. The drugs Acyclovir and Famciclovir have been mentioned in the context of this disorder. Affiliated tissues include testes, lymph node and t cells, and related phenotypes are digestive/alimentary and hematopoietic system

Disease Ontology : 12 A herpes simplex that results in infection located in genital system, or located in rectum, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which is transmitted by sexual contact. The infection has symptom sores, has symptom fever, and has symptom swollen glands.

Wikipedia : 76 Genital herpes is an infection by herpes simplex virus (HSV) of the genitals. Most people either have no... more...

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Related Diseases for Genital Herpes

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Diseases related to Genital Herpes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 viral infectious disease 30.9 CCL5 IL10 IL4 TLR9
2 meningitis 30.1 IL10 TLR2 TLR9
3 chlamydia 30.1 IL10 IL4 TLR2
4 human immunodeficiency virus infectious disease 30.1 CCL5 IL10 TLR9
5 dermatitis 30.0 IL18 IL4 TLR9
6 common variable immunodeficiency 29.5 IL10 IL4 TLR2 TLR9
7 herpes simplex 11.9
8 herpes simplex encephalitis 11.4
9 tropical endomyocardial fibrosis 10.2 IL10 IL4
10 endomyocardial fibrosis 10.2 IL10 IL4
11 hyperlucent lung 10.2 IL10 IL4
12 tungiasis 10.2 IL10 IL4
13 nickel allergic contact dermatitis 10.2 IL10 IL4
14 retinitis pigmentosa 22 10.2 IL10 IL4
15 baylisascariasis 10.2 IL10 IL4
16 penicillin allergy 10.2 IL10 IL4
17 gaucher disease, type ii 10.2 IL10 IL4
18 vulvovaginitis 10.2 CCL5 IL10
19 chronic conjunctivitis 10.2 CCL5 IL4
20 apple allergy 10.2 IL10 IL4
21 beta-lactam allergy 10.2 IL10 IL4
22 kimura disease 10.2 CCL5 IL4
23 eosinophilic meningitis 10.2 IL10 IL4
24 vernal keratoconjunctivitis 10.2 CCL5 IL4
25 autoimmune gastritis 10.2 IL10 IL4
26 folliculitis 10.2 CCL5 IL4
27 trichuriasis 10.2 IL10 PI3
28 buruli ulcer 10.2 IL10 IL4
29 acute cervicitis 10.2 CCL5 TLR2
30 herpes zoster 10.2
31 bardet-biedl syndrome 15 10.2 IL10 IL4
32 griscelli syndrome, type 2 10.2 CCL5 IL10
33 neurosyphilis 10.2 IL10 TLR2
34 poliomyelitis 10.1 IL10 IL4
35 orofacial granulomatosis 10.1 CCL5 IL10 IL4
36 eales disease 10.1 IL10 IL4
37 vulvovaginal candidiasis 10.1 IL4 TLR2
38 eye lymphoma 10.1 IL10 TLR9
39 allergic asthma 10.1 CCL5 IL10 IL4
40 interstitial lung disease 10.1 CCL5 IL10 IL4
41 mycetoma 10.1 CCL5 IL10
42 mucocutaneous leishmaniasis 10.1 IL10 TLR9
43 latex allergy 10.1 IL18 IL4
44 necrotizing ulcerative gingivitis 10.1 IL10 IL18
45 eosinophilic gastritis 10.1 IL18 IL4
46 primary systemic mycosis 10.1 IL10 IL4 TLR2
47 q fever 10.1 IL10 IL4 TLR2
48 aphthous stomatitis 10.1 IL10 IL4 TLR2
49 paracoccidioidomycosis 10.1 IL10 IL4 TLR2
50 spotted fever 10.1 CCL5 IL10

Comorbidity relations with Genital Herpes via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Genital Herpes:



Diseases related to Genital Herpes
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Symptoms & Phenotypes for Genital Herpes

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Symptoms:

12
  • • fever
  • • sores
  • • swollen gl

UMLS symptoms related to Genital Herpes:


fever, pruritus, pelvic pain

MGI Mouse Phenotypes related to Genital Herpes:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.92 APOE IL10 IL18 IL4 TBX21 TBXT
2 hematopoietic system MP:0005397 9.86 APOE CCL5 IL10 IL18 IL4 TBX21
3 homeostasis/metabolism MP:0005376 9.81 ACKR1 APOE IL10 IL18 IL4 TBX21
4 immune system MP:0005387 9.61 ACKR1 APOE CCL5 IL10 IL18 IL4
5 integument MP:0010771 9.1 APOE IL10 IL18 IL4 TBXT TLR2
Sources

Drugs & Therapeutics for Genital Herpes

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Drugs for Genital Herpes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59277-89-3 2022
2
Famciclovir Approved, Investigational Phase 4,Phase 3 104227-87-4 3324
3
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
4 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 valacyclovir Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 2-Aminopurine Phase 4,Phase 3
8 Antimetabolites Phase 4,Phase 3
9 Reverse Transcriptase Inhibitors Phase 4
10 Anti-HIV Agents Phase 4
11 Anti-Retroviral Agents Phase 4
12 Nucleic Acid Synthesis Inhibitors Phase 4
13
Halofantrine Approved Phase 3 69756-53-2 37393
14
Aluminum sulfate Approved Phase 3 10043-01-3
15 Immunologic Factors Phase 3,Phase 2,Phase 1
16 Vaccines Phase 3,Phase 2,Phase 1
17 Krestin Phase 3,Phase 2
18 Monophosphoryl lipid A Phase 3
19 Anti-Bacterial Agents Phase 3
20 Protective Agents Phase 3
21 interferons Phase 3
22 Adjuvants, Immunologic Phase 3,Phase 2
23 Radiation-Protective Agents Phase 3
24 Antibiotics, Antitubercular Phase 3
25 Interferon Inducers Phase 3
26 Lecithin Phase 2
27
QS 21 Phase 2 141256-04-4
28 Antibodies Phase 2
29 Immunoglobulins Phase 2
30 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show top 50) (show all 76)
# Name Status NCT ID Phase Drugs
1 Effect of HSV-2 Suppressive Therapy on Sexual Behavior Unknown status NCT00495716 Phase 4 acyclovir;acyclovir
2 Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients Completed NCT00477334 Phase 4 Famciclovir;Placebo
3 A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies. Completed NCT00158860 Phase 4 valaciclovir (VALTREX®)
4 RELIEF: Randomized Episodic Versus Long-Term Suppression Experience With Famciclovir Completed NCT00219310 Phase 4 Famciclovir
5 A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding Completed NCT00129818 Phase 4 Famciclovir
6 Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV Completed NCT00527618 Phase 4 valacyclovir;acyclovir
7 Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) Shedding Completed NCT01448616 Phase 4 TDF;Placebo Vaginal Gel;Vaginal TFV Gel;Placebo Tablets
8 Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT01346475 Phase 4 valacyclovir;Valacyclovir
9 Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 Completed NCT00362297 Phase 4 acyclovir;valacyclovir
10 VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2 Completed NCT00306293 Phase 4 valacyclovir
11 A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation Completed NCT00723229 Phase 4 acyclovir
12 VALTREX Once Daily For Viral Shedding In Herpes Simplex Virus 2 (HSV-2) Seropositive Subjects. VALTREX® Tablet is a Trademark of GlaxoSmithKline Group of Companies. Completed NCT00116844 Phase 4 Valaciclovir;Placebo
13 A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons Terminated NCT00079911 Phase 4 valacyclovir hydrochloride
14 A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients Unknown status NCT00005663 Phase 3 Valacyclovir hydrochloride
15 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
16 Efficacy and Safety of Famciclovir 1-day Treatment Compared to 3-day Treatment With Valacyclovir in Adults With Recurrent Genital Herpes Completed NCT00306787 Phase 3 Famciclovir;Valacyclovir;Placebo matching famciclovir;Placebo matching valacyclovir
17 Efficacy and Safety of Oral Famciclovir in Patients With Active Recurrent Genital Herpes Completed NCT00171990 Phase 3 Famciclovir
18 Efficacy of Oral Famciclovir 125mg Comparing to Aciclovir 200 mg Treatment in Patients With Active Recurrent Genital Herpes Completed NCT01281007 Phase 3 Famciclovir;Aciclovir
19 Safety of a Herpes Simplex Candidate Vaccine (gD2t) With MPL and Its Efficacy to Prevent Genital Herpes Disease Completed NCT00699764 Phase 3
20 HerpeVac Trial for Young Women Completed NCT00057330 Phase 3
21 A Study of Acyclovir to Help Prevent HIV Infection in People With Genital Herpes Completed NCT00076232 Phase 3 Acyclovir;Acyclovir placebo
22 Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects Completed NCT00698568 Phase 3
23 Herpes Simplex Virus Type 2 (HSV-2) Suppression to Prevent HIV Transmission Completed NCT00194519 Phase 3 Generic acyclovir;Placebo
24 Open-label Study of ASP2151 in Herpes Simplex Patients Completed NCT02209324 Phase 3 ASP2151
25 Valaciclovir to Prevent Transmission of Herpes Simplex Virus Completed NCT00001649 Phase 3 Valaciclovir
26 Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection Completed NCT00262106 Phase 3 PRO 2000/5;Placebo
27 Valaciclovir Hydrochloride Phase III for Hematopoietic Stem Cell Transplantation Patients Completed NCT01602562 Phase 3 VACV tablets (Adults or pediatrics) or granules (pediatrics)
28 Can Valacyclovir Delay the Need for Initiation of Human Immunodeficiency Virus (HIV) Treatment in HIV-infected Individuals? Completed NCT00860977 Phase 3 valacyclovir;Placebo
29 Effect of Male Circumcision on HIV Incidence (ANRS 1265) Terminated NCT00122525 Phase 3
30 Maintenance Dose Study of GEN-003 in Subjects With Genital Herpes Infection Completed NCT03146403 Phase 2
31 A Study With ASP2151 in Subjects With Recurrent Episodes of Genital Herpes Completed NCT00486200 Phase 2 ASP2151;valacyclovir;Placebo
32 Biological Efficacy Study of HerpV Vaccine With QS-21 to Treat Subjects With Recurrent Genital Herpes Completed NCT01687595 Phase 2 HerpV and QS-21;Placebo
33 Randomised Controlled Trial Assessing the Impact of Genital Herpes Suppressive Therapy on HIV Shedding Completed NCT00158509 Phase 2 Valacyclovir
34 Evaluating New Formulation of Therapeutic HSV-2 Vaccine Completed NCT02515175 Phase 2 Placebo
35 Safety and Efficacy Trial of DNA Vaccines to Treat Genital Herpes in Adults Completed NCT02030301 Phase 1, Phase 2
36 Safety and Efficacy Study for a New Antiviral Drug to Treat Genital Herpes Type 2 Completed NCT01047540 Phase 2 AIC316;AIC316;AIC316;AIC316;Placebo
37 Dose Ranging Safety and Efficacy of Therapeutic HSV-2 Vaccine Completed NCT02114060 Phase 2
38 Rollover Trial for Placebo Subjects Previously Enrolled Into GEN-003-002 Study Completed NCT02300142 Phase 2
39 Safety and Immunogenicity Study of Therapeutic HSV-2 Vaccine Completed NCT01667341 Phase 1, Phase 2
40 Retention and Duration of Activity of SPL7013 (VivaGel®) After Vaginal Dosing. Completed NCT00740584 Phase 1, Phase 2 3% SPL7013 Gel (VivaGel)
41 Anti-Herpetic Treatment of Genital Ulcer : Effect on HIV & Herpes Shedding (ANRS 1212) Completed NCT00158483 Phase 2 Acyclovir (ACV)
42 Acyclovir to Treat Patients Co-infected With HIV and Herpes Viruses in Uganda Completed NCT00405821 Phase 2 Acyclovir;Placebo
43 Safety and Efficacy Study of Herpes Simplex Virus Type 2 (HSV-2) Therapeutic DNA Vaccine Active, not recruiting NCT02837575 Phase 2
44 A Phase 2 Trial to Evaluate the Safety and Efficacy of UB-621 in Adults With Recurrent Genital HSV-2 Infection. Not yet recruiting NCT03595995 Phase 2
45 A Study to Investigate the Efficacy, Safety and Tolerability of PEG in Patients With Genital Herpes Terminated NCT01765114 Phase 2 PEG-Formulation
46 Safety and Efficacy Comparator Trial of a New Drug Against Genital Herpes Terminated NCT01658826 Phase 2 AIC316;Valacyclovir
47 Safety Study of HSV2 DNA Vaccine to Treat Patients With Recurrent Genital Herpes Caused by HSV-2 Completed NCT00274300 Phase 1
48 Trial Evaluating Safety, Tolerability and Immune Response of AG-707 Completed NCT00231049 Phase 1 AG-707
49 Study of the Safety of a Particular Herpes Vaccine in Adults With or Without Herpes Infection Completed NCT01915212 Phase 1
50 Study to Evaluate the Safety and Pharmacokinetics of Single Doses of ASP2151 in Healthy Male Subjects and the Effects of Food Completed NCT02852876 Phase 1 ASP2151;Placebo

Search NIH Clinical Center for Genital Herpes

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: herpes genitalis

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Genetic Tests for Genital Herpes

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Anatomical Context for Genital Herpes

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MalaCards organs/tissues related to Genital Herpes:

41
Testes, Lymph Node, T Cells, Skin, Cervix, Brain, Eye

The Foundational Model of Anatomy Ontology organs/tissues related to Genital Herpes:

19
Genital System, Rectum
Sources

Publications for Genital Herpes

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Articles related to Genital Herpes:

(show top 50) (show all 1127)
# Title Authors Year
1
The HSV-1 live attenuated VC2 vaccine provides protection against HSV-2 genital infection in the guinea pig model of genital herpes. ( 30471955 )
2019
2
CXCL17 Chemokine-Dependent Mobilization of CXCR8<sup>+</sup>CD8<sup>+</sup> Effector Memory and Tissue-Resident Memory T Cells in the Vaginal Mucosa Is Associated with Protection against Genital Herpes. ( 29549178 )
2018
3
Interferon epsilon in the reproductive tract of healthy and genital herpes simplex virus-infected pregnant women: Results of a pilot study. ( 29905034 )
2018
4
Genome-Wide Surveillance of Genital Herpes Simplex Virus Type 1 From Multiple Anatomic Sites Over Time. ( 29920588 )
2018
5
STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice. ( 29608601 )
2018
6
Prevention and management of genital herpes simplex infection during pregnancy and delivery: Guidelines from the French College of Gynaecologists and Obstetricians (CNGOF). ( 29571124 )
2018
7
Health-related quality of life of young people and adults with primary or recurrent episodes of genital herpes: a mixed methods systematic review protocol. ( 29762300 )
2018
8
Prospective cohort study showing persistent HSV-2 shedding in women with genital herpes 2 years after acquisition. ( 29175899 )
2018
9
Genital herpes stigma: Toward the Measurement and Validation of a highly prevalent yet hidden public health problem. ( 29629409 )
2018
10
Effects of Different Doses of GEN-003, a Therapeutic Vaccine for Genital Herpes Simplex Virus-2, on Viral Shedding and Lesions: Results of a Randomized Placebo-Controlled Trial. ( 29982727 )
2018
11
Herpes Simplex Virus Shedding Rate: Surrogate Outcome for Genital Herpes Recurrence Frequency and Lesion Rates, and Phase 2 Clinical Trials End Point for Evaluating Efficacy of Antivirals. ( 30020484 )
2018
12
Should Caesarian Section Be Offered to Women With Recurrent Genital Herpes Simplex Lesions After >4 Hours of Ruptured Membranes? ( 30103879 )
2018
13
The effect of hormonal contraception and menstrual cycle timing on genital herpes simplex virus-2 shedding and lesions. ( 30148758 )
2018
14
Evaluation of an Integrated Cell Culture-based and PCR Assay for Diagnosis of Genital Herpes in Women. ( 30390721 )
2018
15
Herpes Simplex Virus 1 and 2 in Herpes Genitalis: A Polymerase Chain Reaction-Based Study from Kerala. ( 30504975 )
2018
16
Antiviral Activity of Tannic Acid Modified Silver Nanoparticles: Potential to Activate Immune Response in Herpes Genitalis. ( 30261662 )
2018
17
A model of genital herpes simplex virus Type 1 infection in Rhesus Macaques. ( 28748667 )
2017
18
Dual-strain genital herpes simplex virus type 2 (HSV-2) infection in the US, Peru, and 8 countries in sub-Saharan Africa: A nested cross-sectional viral genotyping study. ( 29281620 )
2017
19
A case of MOG antibody-positive bilateral optic neuritis and meningoganglionitis following a genital herpes simplex virus infection. ( 29055448 )
2017
20
Serologic Screening for Genital Herpes Infection: Recommendation Statement. ( 28671418 )
2017
21
First-episode genital herpes: interventions for men and women. ( 28120659 )
2017
22
Potential risk of developing herpes simplex encephalitis in patients treated with sildenafil following primary exposure to genital herpes. ( 28956417 )
2017
23
Therapeutic Vaccine for Genital Herpes Simplex Virus-2 Infection: Findings From a Randomized Trial. ( 28329211 )
2017
24
Leflunomide in the Treatment of a Pseudotumoral Genital Herpes Simplex Virus Infection in an HIV Patient. ( 28373917 )
2017
25
Dorsal longitudinal foreskin cut is associated with reduced risk of HIV, syphilis and genital herpes in men: a cross-sectional study in Papua New Guinea. ( 28406272 )
2017
26
No. 207-Genital Herpes: Gynaecological Aspects. ( 28625289 )
2017
27
Genital herpes. ( 28619732 )
2017
28
2017 European guidelines for the management of genital herpes. ( 28836892 )
2017
29
Primary syphilis in pregnancy mistaken for genital herpes: A preventable cause of congenital syphilis. ( 29103618 )
2017
30
Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-I^ Expression. ( 28893956 )
2017
31
Serologic Screening for Genital Herpes Infection. ( 28671417 )
2017
32
Comparison of Acyclovir and Multistrain Lactobacillus brevis in Women with Recurrent Genital Herpes Infections: a Double-Blind, Randomized, Controlled Study. ( 28852985 )
2017
33
Extensive and refractory genital herpes in human immunodeficiency virus-infected patient successfully treated with imiquimod: Case report and literature review. ( 28164895 )
2017
34
A Comparative Analysis of Polymerase Chain Reaction and Direct Fluorescent Antibody Test for Diagnosis of Genital Herpes. ( 28042218 )
2017
35
A trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection model. ( 28481687 )
2017
36
Genital Herpes Infection in an Adolescent with Diabetes Mellitus. ( 28891491 )
2017
37
Recurrent herpes labialis and HSV-1 herpes genitalis: which is the link? ( 28181784 )
2017
38
Recalcitrant hypertrophic herpes genitalis in HIV-infected patient successfully treated with topical imiquimod. ( 28261899 )
2017
39
Genital herpes. ( 27109044 )
2016
40
Medroxyprogesterone acetate and levonorgestrel increase genital mucosal permeability and enhance susceptibility to genital herpes simplex virus type 2 infection. ( 27007679 )
2016
41
Collaboration with a midwife in the care of a pregnant patient with recurrent genital herpes simplex virus. ( 27412208 )
2016
42
Serologic Screening for Genital Herpes: An Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. ( 27997660 )
2016
43
Genital Herpes. ( 27959657 )
2016
44
Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir. ( 27621592 )
2016
45
Role of type-specific herpes simplex virus-1 and 2 serology as a diagnostic modality in patients with clinically suspected genital herpes: A comparative study in Indian population from a tertiary care hospital. ( 27510668 )
2016
46
Genital Herpes: What You Should Know. ( 27281843 )
2016
47
Attitudes and Willingness to Assume Risk of Experimental Therapy to Eradicate Genital Herpes Simplex Virus Infection. ( 27513383 )
2016
48
Current Concepts for Genital Herpes Simplex Virus Infection: Diagnostics and Pathogenesis of Genital Tract Shedding. ( 26561565 )
2016
49
JAMA patient page: Screening for Genital Herpes. ( 27997655 )
2016
50
Integrative pharmacokinetic-pharmacodynamic modeling and simulation of amenamevir (ASP2151) for treatment of recurrent genital herpes. ( 27461507 )
2016
Sources

Variations for Genital Herpes

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Expression for Genital Herpes

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Search GEO for disease gene expression data for Genital Herpes.
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Pathways for Genital Herpes

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Pathways related to Genital Herpes according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Akt Signaling 64
Show member pathways
 13.17 CCL5 IL10 IL18 IL4 TLR2 TLR9
2
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.79 CCL5 IL10 IL18 TLR2 TLR9
3
Influenza A 37
Show member pathways
 12.6 CCL5 IL18 IL4 TLR2 TLR9
4
Th17 cell differentiation 37
Show member pathways
 12.34 IL10 IL18 IL4 TBX21 TLR2
5
NF-kappaB Signaling 4
12.15 CCL5 IL10 IL4 TBX21 TLR2 TLR9
6
Toxoplasmosis 37
Show member pathways
 12.06 IL10 IL4 TLR2
7
Tuberculosis 37
12.03 IL10 IL18 TLR2 TLR9
8
Bacterial infections in CF airways 22
Show member pathways
 11.98 IL4 TLR2 TLR9
9
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.88 CCL5 IL10 IL18 IL4
10
Interleukin-4 and 13 signaling 66
11.81 IL10 IL18 IL4
11
IL12-mediated signaling events 1
Show member pathways
 11.79 IL18 IL4 TBX21
12
Rheumatoid arthritis 37
11.65 CCL5 IL18 TLR2
13
Innate Lymphoid Cell Differentiation Pathways 65
11.57 IL10 IL18 IL4 TBX21
14
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.47 CCL5 IL10 IL18 IL4
15
Th1 Differentiation Pathway 65
Show member pathways
 11.47 IL10 IL18 TBX21 TLR2 TLR9
16
Interleukin-10 signaling 66
11.25 CCL5 IL10 IL18 IL4
17
African trypanosomiasis 37
11.18 IL10 IL18 TLR9
18
Development and heterogeneity of the ILC family 1
11.11 IL18 IL4 TBX21
19
Cytokines and Inflammatory Response 1
11.08 IL10 IL4
20
IL12 signaling mediated by STAT4 1
11.05 IL18 TBX21
21
G-protein signaling_RhoB regulation pathway 22
11.03 CCL5 IL10 IL18 IL4
22
OX40 Pathway 64
11.01 IL10 IL4
23
IL1 and megakaryocytes in obesity 1
10.99 IL18 TLR2
24
G-protein signaling_Rap2B regulation pathway 22
10.83 CCL5 IL10 IL18 IL4
25
Malaria 37
10.71 ACKR1 IL10 IL18 TLR2 TLR9
Sources

GO Terms for Genital Herpes

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Cellular components related to Genital Herpes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 APOE CCL5 IFNL4 IL10 IL18 IL4
2 extracellular region GO:0005576 9.17 APOE CCL5 IL10 IL18 IL4 PI3

Biological processes related to Genital Herpes according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.88 CCL5 IL10 IL18 IL4
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL18 TLR2 TLR9
3 regulation of signaling receptor activity GO:0010469 9.8 CCL5 IFNL4 IL10 IL18 IL4
4 positive regulation of gene expression GO:0010628 9.77 IL18 IL4 TBX21 TLR2 TLR9
5 positive regulation of inflammatory response GO:0050729 9.74 IL18 TLR2 TLR9
6 immune response GO:0006955 9.73 CCL5 IL10 IL18 IL4 TLR2 TLR9
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.7 CCL5 IL18 IL4
8 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.66 TLR2 TLR9
9 triglyceride homeostasis GO:0070328 9.65 APOE IL18
10 negative regulation of interleukin-6 production GO:0032715 9.65 IL10 TLR9
11 positive regulation of interleukin-8 production GO:0032757 9.65 TLR2 TLR9
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.65 IL18 TLR2 TLR9
13 positive regulation of interferon-beta production GO:0032728 9.64 TLR2 TLR9
14 positive regulation of interleukin-12 production GO:0032735 9.64 TLR2 TLR9
15 positive regulation of interleukin-10 production GO:0032733 9.63 TLR2 TLR9
16 positive regulation of chemokine production GO:0032722 9.62 TLR2 TLR9
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.62 TLR2 TLR9
18 regulation of cytokine secretion GO:0050707 9.61 TLR2 TLR9
19 I-kappaB phosphorylation GO:0007252 9.61 TLR2 TLR9
20 neutrophil activation GO:0042119 9.6 CCL5 IL18
21 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.59 IL18 TLR9
22 positive regulation of isotype switching to IgG isotypes GO:0048304 9.58 IL4 TBX21
23 negative regulation of interleukin-8 production GO:0032717 9.55 IL10 TLR9
24 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IL10 IL4
25 positive regulation of interleukin-18 production GO:0032741 9.51 TLR2 TLR9
26 lipopolysaccharide-mediated signaling pathway GO:0031663 9.5 CCL5 IL18 TLR2
27 tumor necrosis factor production GO:0032640 9.49 TLR2 TLR9
28 positive regulation of toll-like receptor signaling pathway GO:0034123 9.46 TLR2 TLR9
29 regulation of isotype switching GO:0045191 9.43 IL10 IL4
30 inflammatory response GO:0006954 9.43 ACKR1 CCL5 IL10 IL18 TLR2 TLR9
31 response to molecule of bacterial origin GO:0002237 9.33 IL10 TLR2 TLR9
32 type 2 immune response GO:0042092 8.8 IL10 IL18 IL4
33 positive regulation of transcription by RNA polymerase II GO:0045944 10.03 IL10 IL18 IL4 TBXT TLR2 TLR9

Molecular functions related to Genital Herpes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL5 IFNL4 IL10 IL18 IL4
2 signaling pattern recognition receptor activity GO:0008329 8.96 TLR2 TLR9
Sources

Sources for Genital Herpes

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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