MCID: GNT003
MIFTS: 54

Genital Herpes

Categories: Immune diseases, Infectious diseases, Reproductive diseases

Aliases & Classifications for Genital Herpes

MalaCards integrated aliases for Genital Herpes:

Name: Genital Herpes 12 54 42 3 15 62 17 70
Herpes Genitalis 12 44
Genital Herpes Simplex 12
Virus-Genital Herpes 12
Venereal Herpes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8704
ICD9CM 34 054.1
MeSH 44 D006558
NCIt 50 C14364
SNOMED-CT 67 154333002
UMLS 70 C0019342

Summaries for Genital Herpes

MedlinePlus : 42 Genital herpes is a sexually transmitted disease (STD) caused by a herpes simplex virus (HSV). It can cause sores on your genital or rectal area, buttocks, and thighs. You can get it from having vaginal, anal, or oral sex with someone who has it. The virus can spread even when sores are not present. Mothers can also infect their babies during childbirth. Symptoms of herpes are called outbreaks. You usually get sores near the area where the virus has entered the body. The sores are blisters which break and become painful, and then heal. Sometimes people do not know they have herpes because they have no symptoms or very mild symptoms. The virus can be more serious in newborn babies or in people with weak immune systems. Repeat outbreaks are common, especially during the first year. Over time, you get them less often and the symptoms become milder. The virus stays in your body for life. There are tests that can diagnose genital herpes. There is no cure. However, medicines can help lessen symptoms, decrease outbreaks, and lower the risk of passing the virus to others. Correct usage of latex condoms can reduce, but not eliminate, the risk of catching or spreading herpes. If your or your partner is allergic to latex, you can use polyurethane condoms. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex.

MalaCards based summary : Genital Herpes, also known as herpes genitalis, is related to herpes simplex and chlamydia, and has symptoms including fever, sores and swollen glands. An important gene associated with Genital Herpes is ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Famciclovir and Acyclovir have been mentioned in the context of this disorder. Affiliated tissues include genital system, rectum and skin, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A herpes simplex that results in infection located in genital system, or located in rectum, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which is transmitted by sexual contact. The infection has symptom sores, has symptom fever, and has symptom swollen glands.

CDC : 3 Genital herpes is a common sexually transmitted disease (STD) that any sexually active person can get. Most people with the virus don't have symptoms. Even without signs of the disease, herpes can still be spread to sex partners.

Wikipedia : 73 Genital herpes is an infection by the herpes simplex virus (HSV) of the genitals. Most people either... more...

Related Diseases for Genital Herpes

Diseases related to Genital Herpes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 470)
# Related Disease Score Top Affiliating Genes
1 herpes simplex 31.2 TNFRSF14 TLR2 NECTIN1 IFI16 GYPC CCL5
2 chlamydia 30.8 TLR2 IL4 IL18 IL10
3 meningitis 30.6 TLR2 IL4 IL18 IL10 CCL5
4 syphilis 30.5 CD8A CD4 CCR6
5 acquired immunodeficiency syndrome 30.3 IL10 CD4 CCR6 APOE
6 toxoplasmosis 30.3 TLR2 IL4 IL10
7 bacterial vaginosis 30.2 TLR2 PI3 IL4 IL10
8 neuritis 30.2 IL4 IL10 CCL5 APOE
9 cervicitis 30.2 IL10 CD8A CD4
10 urethritis 30.2 TLR2 IL10 CD8A CD4
11 filariasis 30.1 TLR2 IL10 CCL5
12 stomatitis 30.0 IL4 IL10 CD4
13 urticaria 30.0 IL4 IL18 IL10 CD4
14 actinomycosis 30.0 IL4 IL10 CD4
15 hepatitis a 29.9 IL4 IL10 CD4
16 primary syphilis 29.9 CD8A CD4
17 scabies 29.8 IL10 CD4 CCR6
18 bronchopneumonia 29.6 IL10 CD8A CD4
19 chickenpox 29.6 IL4 IL10 GYPC CD8A CD4 CCR6
20 vaginitis 29.5 TLR2 IL10 CD4 CCR6 CCL5
21 anogenital venereal wart 29.5 CD8A CD4 CCR6
22 herpes zoster 29.4 TLR2 IL10 GYPC CD8A CD4 CCR6
23 contact dermatitis 29.3 TLR2 IL4 IL18 IL10 CD4 CCR6
24 herpetic whitlow 29.3 TNFRSF14 NECTIN1 CD4 ACKR1
25 crohn's disease 29.3 TLR2 IL4 IL18 IL10 CD4 CCR6
26 bacterial infectious disease 29.3 TLR2 IL18 IL10 CD80 CD4 CCR6
27 nervous system disease 29.2 IL4 IL10 CD8A CD4 CCR6 APOE
28 immune deficiency disease 29.2 TLR2 IL4 IL18 IL10 CD8A CD80
29 disease by infectious agent 29.2 TLR2 IL4 IL18 IL10 CD8A CD4
30 meningoencephalitis 29.2 IL10 CD8A CD4 CCR6 CCL5
31 exanthem 29.1 IL18 IL10 CD8A CD4 CCR6
32 human immunodeficiency virus infectious disease 29.1 IL4 IL10 CD8A CD80 CD4 CCR6
33 peripheral nervous system disease 29.1 IL4 IL10 CD8A CD4 CCR6
34 leukemia, chronic lymphocytic 29.1 IL4 IL10 CD8A CD80 CD4 CCR6
35 keratitis, hereditary 29.0 TLR2 IL10 CD8A CD4 CCR6 ACKR1
36 vaginal disease 29.0 TLR2 IL10 CD8A CD4 CCR6 CCL5
37 listeriosis 29.0 TLR2 TBX21 IL18 IL10 CD8A CD4
38 skin disease 29.0 TLR2 PI3 IL4 IL18 IL10 CD8A
39 eye disease 29.0 IL4 IL10 CD8A CD4 CCR6 CCL5
40 dermatitis 28.9 TLR2 IL4 IL18 IL10 CD8A CD4
41 mollaret meningitis 11.2
42 herpes simplex encephalitis 11.1
43 congenital herpes simplex 11.0
44 neonatal herpes 10.7
45 tropical endomyocardial fibrosis 10.4 IL4 IL10
46 acute cervicitis 10.4 TLR2 IL10
47 acute gonococcal cervicitis 10.4 IL4 IL10
48 spotted fever rickettsiosis 10.4 IL10 CCL5
49 neurosyphilis 10.4 TLR2 IL10
50 cutaneous leishmaniasis 10.4 TLR2 IL4 IL10

Comorbidity relations with Genital Herpes via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Genital Herpes:



Diseases related to Genital Herpes

Symptoms & Phenotypes for Genital Herpes

Symptoms:

12
  • fever
  • sores
  • swollen glands

UMLS symptoms related to Genital Herpes:


fever; pruritus; pelvic pain

MGI Mouse Phenotypes related to Genital Herpes:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 APOE CCL5 CCR6 CD4 CD80 CD8A
2 immune system MP:0005387 10.03 ACKR1 APOE CCL5 CCR6 CD4 CD80
3 digestive/alimentary MP:0005381 9.92 APOE CD4 IL10 IL18 IL4 TBX21
4 integument MP:0010771 9.65 APOE CD4 CD8A IFNE IL10 IL18
5 nervous system MP:0003631 9.4 APOE CCR6 CD4 CD80 CD8A IFI16

Drugs & Therapeutics for Genital Herpes

Drugs for Genital Herpes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Famciclovir Approved, Investigational Phase 4 104227-87-4 3324
2
Acyclovir Approved Phase 4 59277-89-3 2022
3
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
4 Antioxidants Phase 4
5 Anti-Infective Agents Phase 4
6 Antiviral Agents Phase 4
7 valacyclovir Phase 4
8
Halofantrine Approved Phase 3 69756-53-2 37393
9
Aluminum sulfate Approved Phase 3 10043-01-3
10 Vaccines Phase 3
11 polysaccharide-K Phase 3
12 Immunologic Factors Phase 3
13 Protective Agents Phase 3
14 interferons Phase 3
15 Antibiotics, Antitubercular Phase 3
16 Monophosphoryl lipid A Phase 3
17 Radiation-Protective Agents Phase 3
18 Adjuvants, Immunologic Phase 3
19 Anti-Bacterial Agents Phase 3
20
Lecithin Experimental Phase 2 8002-43-5
21
Pritelivir Investigational Phase 2 348086-71-5
22 Anti-Retroviral Agents Phase 2
23 Antibodies Phase 2
24 Immunoglobulins Phase 2
25 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show top 50) (show all 63)
# Name Status NCT ID Phase Drugs
1 Effects of Melatonin in the Treatment of Genital Herpes Unknown status NCT03831165 Phase 4 Acyclovir 400 MG
2 An International, Randomized, Double-Blind, Placebo-Controlled, Multicenter, 6-Month Study of the Efficacy and Safety of Valtrex 1g QD vs. Placebo for the Suppression of HSV-2 Genital Herpes in Newly Diagnosed Immunocompetent Patients Completed NCT00158860 Phase 4 Valaciclovir;Placebo
3 Valacyclovir for the Suppression of HSV-2 Viral Shedding in HSV-2 Seropositive Individuals With No History of Symptomatic GH Completed NCT00116844 Phase 4 Valaciclovir;Placebo
4 A Randomized, Cross-Over Study to Evaluate the Suppressive Effect of High-Dose Acyclovir Versus Once Daily Valacyclovir on Herpes Simplex Virus Type 2 Genital Shedding in Herpes Simplex Virus-2 Seropositive Adults Completed NCT00362297 Phase 4 acyclovir;valacyclovir
5 A Randomized, Multicenter, Double-blind Study to Compare the Efficacy of Single-day Treatment (1000 mg b.i.d.) With Famciclovir Compared to That of Placebo in Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Immunocompetent Black Patients Completed NCT00477334 Phase 4 Famciclovir;Placebo
6 A Study to Determine the Safety and Efficacy of Famciclovir in the Episodic and Suppressive Treatment of Recurrent Genital Herpes (RGH). The Study Will Also Evaluate Quality of Life and Patient Satisfaction Completed NCT00219310 Phase 4 Famciclovir
7 A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding Completed NCT00129818 Phase 4 Famciclovir
8 A Randomized, Cross-Over Study to Evaluate the Suppressive Effect of High-Dose Valacyclovir Versus Once Daily Valacyclovir on Herpes Simplex Virus Type 2 Genital Shedding in Herpes Simplex Virus-2 Seropositive Adults Completed NCT01346475 Phase 4 valacyclovir;Valacyclovir
9 A Randomized, Cross-Over Study to Evaluate the Suppressive Effect of Acyclovir on Rapidly Cleared Herpes Simplex Virus Type 2 Genital Reactivation Episodes in Herpes Simplex Virus-2 Seropositive Adults Completed NCT00723229 Phase 4 acyclovir
10 A Randomized, Open-label, Crossover Trial of the Effect of Dosing of Daily HSV-2 Suppressive Therapy on HSV Reactivation and Plasma HIV-1 Levels Among HIV-1/ HSV-2 Co-infected Persons Completed NCT00527618 Phase 4 valacyclovir;acyclovir
11 The Effect of Valacyclovir 1g Once Daily on HSV-2 Viral Shedding in Subjects Newly Diagnosed With Genital Herpes Infection Completed NCT00306293 Phase 4 valacyclovir
12 Randomized, Placebo-controlled, Double-blind Study to Evaluate the Efficacy of 2LHERP® in Patients With Recurrent Genital Herpes Infections Recruiting NCT04235322 Phase 4 2LHERP®;Placebo
13 Effect of Suppressive Therapy on Behavioral Determinants of HSV-2 Transmission Terminated NCT00495716 Phase 4 acyclovir;acyclovir
14 An International, Randomized, Double-Blind, Placebo-Controlled Study of Valaciclovir for the Suppression and Episodic Treatment of Genital HSV Infection in HIV-Infected Persons With CD4+ Lymphocyte Count <100 Cells/mm3. Terminated NCT00079911 Phase 4 valacyclovir hydrochloride
15 Trial of Male Circumcision: HIV, STD and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
16 An International, Randomized, Double-Blind, Placebo-Controlled Study of Valacyclovir for the Suppression of Recurrent Ano-Genital HSV Infections in HIV-Infected Subjects Unknown status NCT00005663 Phase 3 Valacyclovir hydrochloride
17 Efficacy and Safety of Oral Famciclovir in Patients With Active Recurrent Genital Herpes Completed NCT00171990 Phase 3 Famciclovir
18 A Multicenter, Randomized, Double-blind Study to Compare the Efficacy and Safety of Patient-initiated Famciclovir 1000 mg b.i.d. x 1 Day to Valacyclovir 500 mg b.i.d. x 3 Days in Immunocompetent Adults With Recurrent Genital Herpes Completed NCT00306787 Phase 3 Famciclovir;Valacyclovir;Placebo matching famciclovir;Placebo matching valacyclovir
19 Phase III Randomized Placebo-Controlled Trial of HSV-2 Suppression to Prevent HIV Transmission Among HIV-Discordant Couples Completed NCT00194519 Phase 3 Generic acyclovir;Placebo
20 Safety of SmithKline Beecham Biologicals' Herpes Simplex Candidate Vaccine (gD2t) With MPL & Its Efficacy to Prevent Genital Herpes Disease in HSV Positive or Negative Consorts of Subjects With Genital Herpes Disease Completed NCT00699764 Phase 3
21 A Prospective, Randomized, Multicenter Study of the Efficacy and Safety of Famciclovir 125 mg Comparing to Aciclovir 200 mg in Patients With Active Recurrent Genital Herpes Completed NCT01281007 Phase 3 Famciclovir;Aciclovir
22 A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Acyclovir for the Reduction of HIV Acquisition Among High-Risk HSV-2 Seropositive, HIV Seronegative Individuals Completed NCT00076232 Phase 3 Acyclovir;Acyclovir placebo
23 An International Multi-centre, Randomised, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of 0.5% and 2% PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection Completed NCT00262106 Phase 3 PRO 2000/5;Placebo
24 A Double-Blind, Randomized, Controlled Phase III Study to Assess the Prophylactic Efficacy and Safety of gD-Alum/MPL Vaccine in the Prevention of Genital Herpes Disease in Young Women Who Are HSV-1 and -2 Seronegative Completed NCT00057330 Phase 3
25 Study to Evaluate the Safety of GSK Biologicals' Herpes Simplex Candidate Vaccine (gD2t) With MPL in HSV Seropositive or Seronegative Subjects Without Genital Herpes Disease Completed NCT00698568 Phase 3
26 Effect of Safe Male Circumcision on Incidence of Infection by HIV, HSV-2 and of Genital Ulceration Terminated NCT00122525 Phase 3
27 Efficacy of an HSV2 Genital Herpes Suppressive Treatment on HIV and HSV2 Genital Shedding Among Co-Infected Patients Receiving or Not Antiretroviral Drugs Completed NCT00158509 Phase 2 Valacyclovir
28 A Phase 2a Multicenter, Double-blinded, Randomized Trial to Evaluate The Effect of HerpV on Viral Shedding in Adults With Recurrent Genital Herpes Completed NCT01687595 Phase 2 HerpV and QS-21;Placebo
29 A Randomized, Double-Blind Study to Evaluate a New Formulation of GEN-003 in Subjects With Genital HSV-2 Infection Completed NCT02515175 Phase 2 Placebo
30 Rollover Trial for Placebo Subjects Previously Enrolled Into GEN-003-002 - Randomized, Double-Blind, Factorial Study to Compare the Safety and Efficacy of Combinations of GEN-003 and Matrix-M2 in Subjects With Genital HSV-2 Completed NCT02300142 Phase 2
31 A Phase I/IIa, Randomized, Double-blind, Dose-ranging, Placebo-controlled Study of the Safety and Immunogenicity of a HSV-2 Vaccine Containing Matrix M-2 Adjuvant in Individuals With Documented Genital HSV-2 Genital Infection Completed NCT01667341 Phase 1, Phase 2
32 A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation, Phase 1/2 Trial to Evaluate the Safety and Efficacy of Herpes Simplex Virus, Type 2 Therapeutic DNA Vaccines in Symptomatic HSV-2-Seropositive Adults Completed NCT02030301 Phase 1, Phase 2
33 A Randomized, Double-Blind, Factorial Study to Compare the Safety and Efficacy of Varying Combinations of GEN-003 and Matrix-M2 in Subjects With Genital HSV-2 Infection Completed NCT02114060 Phase 2
34 A Phase II, Dose-Finding Study With ASP2151 in Subjects With Recurrent Episodes of Genital HErpes Completed NCT00486200 Phase 2 ASP2151;valacyclovir;Placebo
35 A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial to Evaluate the Safety and Efficacy of Herpes Simplex Virus, Type 2 (HSV-2) Therapeutic DNA Vaccine in Adults With Symptomatic Genital HSV-2 Infection Completed NCT02837575 Phase 2
36 Anti-Herpetic Treatment Associated With Syndromic Management of Genital Ulcer in Africa: Clinical and Biological Evaluation on HIV-1 and HSV-2 Shedding (ANRS 1212) Completed NCT00158483 Phase 2 Acyclovir (ACV)
37 A Randomized, Double-Blind, Placebo-Controlled Trial of Acyclovir Prophylaxis Versus Placebo Among HIV-1/HSV-2 Co-Infected Individuals in Uganda Completed NCT00405821 Phase 2 Acyclovir;Placebo
38 Assessment of Local Retention and Duration of Activity of SPL7013 Following Vaginal Application of 3% SPL7013 Gel (VivaGel) in Healthy Volunteers Completed NCT00740584 Phase 1, Phase 2 3% SPL7013 Gel (VivaGel)
39 Safety and Efficacy of 4 Investigational HSV 2 Vaccines Administered by Intramuscular Route in Adults With Recurrent Genital Herpes Caused by HSV 2 Active, not recruiting NCT04222985 Phase 1, Phase 2
40 A Randomized, Double-Blind, Double-Dummy Phase II Study of Single Dose HDIT101 Versus Standard of Care Valaciclovir in Patients With Chronic Recurrent Anogenital HSV-2 Infection Active, not recruiting NCT04165122 Phase 2 Valaciclovir;Valaciclovir placebo
41 A Two-Stage, Randomized, Double-Blind, Dose-Ranging, Phase 2 Trial to Evaluate the Safety and Efficacy of UB-621 on HSV Shedding in Adults With Recurrent Genital HSV-2 Infection. Not yet recruiting NCT03595995 Phase 2
42 A Randomized, Single-blind, Dose-selected Phase II Trial to Evaluate the Safety and Efficacy of UB-621 in Adults With Recurrent Genital HSV-2 Infection Not yet recruiting NCT04714060 Phase 2
43 A Phase II Open-label, Intra-individual Controlled, Single-center Study to Investigate the Efficacy, Safety and Tolerability of a Polyethylene Glycol-formulation and the Viral Shedding in Patients Suffering From Genital Herpes Terminated NCT01765114 Phase 2 PEG-Formulation
44 A Randomized, Placebo-controlled, Double-blind Study to Assess the Efficacy and Safety of a Maintenance Dose of GEN-003 in Subjects With Genital Herpes Infection Terminated NCT03146403 Phase 2
45 A Double-blind, Double Dummy, Randomized Crossover Trial to Compare the Effect of "AIC316 (Pritelivir)" 100 mg Once Daily Versus Valacyclovir 500 mg Once Daily on Genital HSV Shedding in HSV-2 Seropositive Adults. Terminated NCT01658826 Phase 2 AIC316;Valacyclovir
46 A Phase 1 Trial Evaluating Safety, Tolerability and Immune Response of AG-707 Compared to Placebo in HSV-2 Seropositive Patients Completed NCT00231049 Phase 1 AG-707
47 A Phase I, Two-Center, Open-Label, Dose-Escalating Study to Investigate the Safety, Tolerability and Immunogenicity of pPJV7630, a Therapeutic DNA Vaccine for Herpes Simplex Virus Type 2 (HSV-2), in Patients With Recurrent Genital Herpes Caused by HSV-2 Completed NCT00274300 Phase 1
48 A Double-Blind, Placebo-Controlled Single Dose Escalating Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP2151 in Healthy Male Subjects, Followed by an Open, Two-Period Crossover Study to Assess the Effect of Fed Conditions on the Safety, Tolerability and Pharmacokinetics of ASP2151 Completed NCT02852876 Phase 1 ASP2151;Placebo
49 A Long-term Follow-up Study of Efficacy and Immunogenicity of GEN-003 in Subjects With Genital Herpes Simplex Virus Type 2 (HSV-2) Infection Completed NCT02910284
50 Serologic Assays for the Diagnosis of Herpes Simplex Virus Type 2: Development of Testing Strategies Completed NCT01112956

Search NIH Clinical Center for Genital Herpes

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Acyclovir
Acyclovir Sodium
famciclovir
Foscarnet
Foscarnet Sodium Hexahydrate
Interferon Alfa-2b
valacyclovir
Valacyclovir hydrochloride

Cochrane evidence based reviews: herpes genitalis

Genetic Tests for Genital Herpes

Anatomical Context for Genital Herpes

The Foundational Model of Anatomy Ontology organs/tissues related to Genital Herpes:

19
Genital System, Rectum

MalaCards organs/tissues related to Genital Herpes:

40
Skin, Cervix, T Cells, Nk Cells, Placenta, Myeloid, B Cells

Publications for Genital Herpes

Articles related to Genital Herpes:

(show top 50) (show all 3301)
# Title Authors PMID Year
1
Herpes Simplex Virus 2 Counteracts Neurite Outgrowth Repulsion during Infection in a Nerve Growth Factor-Dependent Manner. 42
32669337 2020
2
Phosphoregulation of a Conserved Herpesvirus Tegument Protein by a Virally Encoded Protein Kinase in Viral Pathogenicity and Potential Linkage between Its Evolution and Viral Phylogeny. 42
32611749 2020
3
High Preventive Effect of G2-S16 Anionic Carbosilane Dendrimer against Sexually Transmitted HSV-2 Infection. 42
32605185 2020
4
Protection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HSV-1-seronegative guinea pigs. 61 54
19702506 2009
5
Placebo-controlled trial of vaccination with recombinant glycoprotein D of herpes simplex virus type 2 for immunotherapy of genital herpes. 61 54
7911177 1994
6
Passive immunization of the vagina protects mice against vaginal transmission of genital herpes infections. 54 61
8158042 1994
7
Estimates of the Prevalence and Incidence of Genital Herpes, United States, 2018. 61
33492103 2021
8
Sexually Transmitted Infections Among US Women and Men: Prevalence and Incidence Estimates, 2018. 61
33492089 2021
9
The Estimated Direct Lifetime Medical Costs of Sexually Transmitted Infections Acquired in the United States in 2018. 61
33492093 2021
10
Genital Mycoplasma, Shigellosis, Zika, Pubic Lice, and Other Sexually Transmitted Infections: Neither Gone Nor Forgotten. 61
33492101 2021
11
Lifetime Medical Costs of Genital Herpes in the United States: Estimates From Insurance Claims. 61
33492102 2021
12
Vulvovaginal candidiasis in Iran: A systematic review and meta-analysis on the epidemiology, clinical manifestations, demographic characteristics, risk factors, etiologic agents and laboratory diagnosis. 61
33741400 2021
13
Serum and Cervicovaginal Fluid Antibody Profiling in Herpes Simplex Virus (HSV) Seronegative Recipients of the HSV529 Vaccine. 61
33718970 2021
14
Genital HSV-1 DNA detection is associated with a low inflammatory profile in HIV-uninfected South African women. 61
32848051 2021
15
Update: Sexually Transmitted Infections, Active Component, U.S. Armed Forces, 2012-2020. 61
33773568 2021
16
Treatment of genital herpes using olive leaf extract. 61
33598284 2021
17
Analysis of the clinical trial results of the flavonoid effects on some cellular immunity indicators in children and adults. 61
33713093 2021
18
Changing Demography of Genital Chlamydia, Gonorrhea, Genital Herpes, Condyloma, and Syphilis Infections in Japan. 61
32611973 2021
19
Age- and Sex-Related Differences in Morbidities of Sexually Transmitted Diseases in Children. 61
33445644 2021
20
Ovariectomized mice and postmenopausal women exhibit analogous loss of genital epithelial integrity. 61
33427560 2021
21
[Brazilian Protocol for Sexually Transmitted Infections 2020: infections that cause genital ulcers]. 61
33729413 2021
22
Recent Advances in Nanosystems and Strategies for Vaginal Delivery of Antimicrobials. 61
33530510 2021
23
TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway. 61
33419081 2021
24
Herpes Simplex Virus Serotyping in Pregnant Women With a History of Genital Herpes and an Outbreak in the Third Trimester of Pregnancy: A Cost-Effectiveness Analysis. 61
33278294 2021
25
Does bacillus Calmette-Guérin vaccine prevent herpes simplex virus recurrences? A systematic review. 61
32975011 2021
26
Genital herpes - diagnosis, treatments, attitudes and response to disclosure amongst members of the UK Herpes Viruses Association. 61
33115318 2021
27
Subclinical Genital Herpes Shedding in HIV/Herpes Simplex Virus 2-Coinfected Women during Antiretroviral Therapy Is Associated with an Increase in HIV Tissue Reservoirs and Potentially Promotes HIV Evolution. 61
33028713 2020
28
Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans. 61
33310865 2020
29
Protection against herpes simplex virus type 2 infection in a neonatal murine model using a trivalent nucleoside-modified mRNA in lipid nanoparticle vaccine. 61
33041105 2020
30
An adult case of parainfectious optic neuritis associated with genital herpes simplex virus type 2 infection. 61
32937275 2020
31
Hemophagocytic Lymphohistiocytosis as the Presenting Manifestation of Relapsed Classic Hodgkin's Lymphoma in the Presence of Concurrent Human Immunodeficiency Virus, Genital Herpes, Epstein-Barr Virus and Mycobacterium Avium Complex Infection. 61
33364090 2020
32
Prevalence of co-infections with other sexually transmitted infections in patients newly diagnosed with anogenital warts in Guangzhou, China. 61
32842906 2020
33
Genotype-Informed Versus Empiric Management Of VirEmia (GIVE MOVE): study protocol of an open-label randomised clinical trial in children and adolescents living with HIV in Lesotho and Tanzania. 61
33076866 2020
34
[Herpes simplex virus and central nervous system infections: encephalitis, meningitis, myelitis]. 61
33111702 2020
35
ACOG Practice Bulletin No. 220: Management of Genital Herpes in Pregnancy. 61
32976371 2020
36
Risk to patients, risk to clinicians: a three-site audit of the documentation of counselling in first episode genital herpes. 61
32915699 2020
37
Impact evaluation of scripted lesson plans for HIV-related content in a life orientation curriculum: results from two provinces in South Africa. 61
33054742 2020
38
Herpes simplex virus type 2 trivalent protein vaccine containing glycoproteins C, D and E protects guinea pigs against HSV-1 genital infection. 61
32347775 2020
39
Herpes Simplex Virus: Epidemiology, Diagnosis, and Treatment. 61
32762854 2020
40
Impact of a single-age cohort human papillomavirus vaccination strategy in Catalonia, Spain: Population-based analysis of anogenital warts in men and women. 61
32565118 2020
41
Use of the Guinea pig model of genital herpes to evaluate vaccines and antivirals: Review. 61
32544409 2020
42
Viral ribonucleotide reductase attenuates the anti-herpes activity of acyclovir in contrast to amenamevir. 61
32569704 2020
43
[Intracellular transport of Alphaherpesvirinae]. 61
32795979 2020
44
Epidemiological Impact of Novel Preventive and Therapeutic HSV-2 Vaccination in the United States: Mathematical Modeling Analyses. 61
32650385 2020
45
Vaccines against Genital Herpes: Where Are We? 61
32727077 2020
46
The Mutation of the Genes Related to Neurovirulence in HSV-2 Produces an Attenuated Phenotype in Mice. 61
32708847 2020
47
; THE ADVANCEMENTS IN TREATMENT OF HIV-INFECTED PATIENTS WITH HERPETIC INFECTION. 61
32965250 2020
48
Herpes simplex virus type 1 in Europe: systematic review, meta-analyses and meta-regressions. 61
32675066 2020
49
Unilateral inguinal lymphadenitis caused by Yersinia pseudotuberculosis. A case report. 61
32386928 2020
50
Contriving a chimeric polyvalent vaccine to prevent infections caused by herpes simplex virus (type-1 and type-2): an exploratory immunoinformatic approach. 61
31328668 2020

Variations for Genital Herpes

Expression for Genital Herpes

Search GEO for disease gene expression data for Genital Herpes.

Pathways for Genital Herpes

Pathways related to Genital Herpes according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TNFRSF14 TLR2 PI3 IL4 IL18 IL10
2
Show member pathways
13.61 TNFRSF14 IL4 IL18 IL10 IFNE CD80
3
Show member pathways
13.32 TNFRSF14 TLR2 IL4 IL18 IL10 CD80
4
Show member pathways
13.29 TNFRSF14 IL4 IL18 IL10 CD80 CD4
5
Show member pathways
13.2 TNFRSF14 NECTIN1 IL4 IL18 IL10 CD80
6
Show member pathways
12.79 IL4 IL10 CD8A CD80 CD4
7 12.74 TNFRSF14 TLR2 NXF1 NECTIN1 CCL5
8
Show member pathways
12.57 IL4 IL18 IL10 CD80 CD4
9
Show member pathways
12.54 TLR2 IL4 IL10 CD8A CD4
10
Show member pathways
12.51 TLR2 TBX21 IL4 IL18 IL10 CD4
11 12.38 TLR2 TBX21 IL4 IL10 IFI16 CD8A
12
Show member pathways
12.26 TLR2 PI3 CD4 CCR6
13
Show member pathways
12.18 TNFRSF14 IL18 IL10 CCR6 CCL5 ACKR1
14 12.07 NECTIN1 CD8A CD80 CD4
15 12.02 IL18 IL10 CD8A CD4
16 11.9 IL4 IL10 CD8A CD80 CD4
17
Show member pathways
11.86 TBX21 IL4 IL18 CD8A CD4
18 11.82 TLR2 IL18 CD80 CCL5
19
Show member pathways
11.8 TLR2 IL4 CD80 CD4
20 11.68 IL10 CD8A CD4
21 11.66 CD8A CD80 CD4
22 11.63 TLR2 IL4 IL10 CCR6
23 11.42 IL4 IL10 CD80 CD4
24 11.35 TLR2 IL18 IL10 GYPC ACKR1
25
Show member pathways
11.31 TLR2 TBX21 IL18 IL10 CD80 CD4
26 11.26 TBX21 IL4 IL18
27 11.24 IL4 IL18 IL10 CD80 CCL5
28 11.21 IL4 IL10 CD4
29 11.18 TBX21 IL18 CD4
30 11.07 TBX21 IL4 IL18 IL10 CD8A CD4
31 10.95 IL4 IL18 IL10 CD80 CCL5

GO Terms for Genital Herpes

Cellular components related to Genital Herpes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 PI3 IL4 IL18 IL10 IFNL4 IFNE
2 extracellular region GO:0005576 9.61 PI3 NECTIN1 IL4 IL18 IL10 IFNE
3 external side of plasma membrane GO:0009897 9.02 TNFRSF14 CD8A CD80 CD4 CCR6

Biological processes related to Genital Herpes according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.95 TBX21 IL4 IL10 CD80 CD4 APOE
2 inflammatory response GO:0006954 9.85 TLR2 IL18 IFI16 CCL5 ACKR1
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.79 TNFRSF14 CD80 CD4
4 viral entry into host cell GO:0046718 9.78 TNFRSF14 NECTIN1 CD80
5 B cell differentiation GO:0030183 9.73 IL4 IL10 IFNE
6 chemokine-mediated signaling pathway GO:0070098 9.72 CCR6 CCL5 ACKR1
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 IL4 IL18 CCL5
8 neutrophil activation GO:0042119 9.6 IL18 CCL5
9 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.59 IL18 CD80
10 regulation of T cell activation GO:0050863 9.58 CD4 CCL5
11 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL4 IL10
12 T cell activation GO:0042110 9.58 IL4 CD8A CD4
13 response to molecule of bacterial origin GO:0002237 9.57 TLR2 IL10
14 positive regulation of T cell proliferation GO:0042102 9.56 IL4 CD80 CD4 CCL5
15 negative regulation of T-helper 17 cell differentiation GO:2000320 9.52 TBX21 IL4
16 positive regulation of isotype switching to IgG isotypes GO:0048304 9.51 TBX21 IL4
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.5 TLR2 IL18 CCL5
18 cytokine-mediated signaling pathway GO:0019221 9.5 IL4 IL18 IL10 IFNE CD80 CD4
19 positive regulation of amyloid-beta clearance GO:1900223 9.49 IL4 APOE
20 lymphocyte migration GO:0072676 9.43 TBX21 CCR6
21 regulation of isotype switching GO:0045191 9.37 IL4 IL10
22 immune response GO:0006955 9.36 TNFRSF14 TLR2 NECTIN1 IL4 IL18 IL10
23 type 2 immune response GO:0042092 9.33 IL4 IL18 IL10

Molecular functions related to Genital Herpes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.65 TLR2 NECTIN1 CD4 CCR6 ACKR1
2 virus receptor activity GO:0001618 9.46 TNFRSF14 NECTIN1 CD80 CD4
3 coreceptor activity GO:0015026 9.26 NECTIN1 CD8A CD80 CD4
4 cytokine activity GO:0005125 9.1 IL4 IL18 IL10 IFNL4 IFNE CCL5

Sources for Genital Herpes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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