Genital Herpes disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GNT003 MIFTS: 54	Genital Herpes Categories: Immune diseases, Infectious diseases, Reproductive diseases
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Aliases & Classifications for Genital Herpes

MalaCards integrated aliases for Genital Herpes:

Name: Genital Herpes ¹² ⁵⁴ ⁴² ³ ¹⁵ ⁶² ¹⁷ ⁷⁰

Herpes Genitalis ¹² ⁴⁴

Genital Herpes Simplex ¹²

Virus-Genital Herpes ¹²

Venereal Herpes ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Immune diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:8704

ICD9CM ³⁴ 054.1

MeSH ⁴⁴ D006558

NCIt ⁵⁰ C14364

SNOMED-CT ⁶⁷ 154333002

EFO ¹⁷ EFO_0007282

UMLS ⁷⁰ C0019342

Sources

Summaries for Genital Herpes

MedlinePlus : ⁴² Genital herpes is a sexually transmitted disease (STD) caused by a herpes simplex virus (HSV). It can cause sores on your genital or rectal area, buttocks, and thighs. You can get it from having vaginal, anal, or oral sex with someone who has it. The virus can spread even when sores are not present. Mothers can also infect their babies during childbirth. Symptoms of herpes are called outbreaks. You usually get sores near the area where the virus has entered the body. The sores are blisters which break and become painful, and then heal. Sometimes people do not know they have herpes because they have no symptoms or very mild symptoms. The virus can be more serious in newborn babies or in people with weak immune systems. Repeat outbreaks are common, especially during the first year. Over time, you get them less often and the symptoms become milder. The virus stays in your body for life. There are tests that can diagnose genital herpes. There is no cure. However, medicines can help lessen symptoms, decrease outbreaks, and lower the risk of passing the virus to others. Correct usage of latex condoms can reduce, but not eliminate, the risk of catching or spreading herpes. If your or your partner is allergic to latex, you can use polyurethane condoms. The most reliable way to avoid infection is to not have anal, vaginal, or oral sex.

MalaCards based summary : Genital Herpes, also known as herpes genitalis, is related to herpes simplex and chlamydia, and has symptoms including fever, sores and swollen glands. An important gene associated with Genital Herpes is ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Famciclovir and Acyclovir have been mentioned in the context of this disorder. Affiliated tissues include genital system, rectum and skin, and related phenotypes are hematopoietic system and immune system

Disease Ontology : ¹² A herpes simplex that results in infection located in genital system, or located in rectum, has material basis in Human herpesvirus 1 or has material basis in Human herpesvirus 2, which is transmitted by sexual contact. The infection has symptom sores, has symptom fever, and has symptom swollen glands.

CDC : ³ Genital herpes is a common sexually transmitted disease (STD) that any sexually active person can get. Most people with the virus don't have symptoms. Even without signs of the disease, herpes can still be spread to sex partners.

Wikipedia : ⁷³ Genital herpes is an infection by the herpes simplex virus (HSV) of the genitals. Most people either... more...

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Related Diseases for Genital Herpes

Diseases related to Genital Herpes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 470)

#	Related Disease	Score	Top Affiliating Genes
1	herpes simplex	31.2	TNFRSF14 TLR2 NECTIN1 IFI16 GYPC CCL5
2	chlamydia	30.8	TLR2 IL4 IL18 IL10
3	meningitis	30.6	TLR2 IL4 IL18 IL10 CCL5
4	syphilis	30.5	CD8A CD4 CCR6
5	acquired immunodeficiency syndrome	30.3	IL10 CD4 CCR6 APOE
6	toxoplasmosis	30.3	TLR2 IL4 IL10
7	bacterial vaginosis	30.2	TLR2 PI3 IL4 IL10
8	neuritis	30.2	IL4 IL10 CCL5 APOE
9	cervicitis	30.2	IL10 CD8A CD4
10	urethritis	30.2	TLR2 IL10 CD8A CD4
11	filariasis	30.1	TLR2 IL10 CCL5
12	stomatitis	30.0	IL4 IL10 CD4
13	urticaria	30.0	IL4 IL18 IL10 CD4
14	actinomycosis	30.0	IL4 IL10 CD4
15	hepatitis a	29.9	IL4 IL10 CD4
16	primary syphilis	29.9	CD8A CD4
17	scabies	29.8	IL10 CD4 CCR6
18	bronchopneumonia	29.6	IL10 CD8A CD4
19	chickenpox	29.6	IL4 IL10 GYPC CD8A CD4 CCR6
20	vaginitis	29.5	TLR2 IL10 CD4 CCR6 CCL5
21	anogenital venereal wart	29.5	CD8A CD4 CCR6
22	herpes zoster	29.4	TLR2 IL10 GYPC CD8A CD4 CCR6
23	contact dermatitis	29.3	TLR2 IL4 IL18 IL10 CD4 CCR6
24	herpetic whitlow	29.3	TNFRSF14 NECTIN1 CD4 ACKR1
25	crohn's disease	29.3	TLR2 IL4 IL18 IL10 CD4 CCR6
26	bacterial infectious disease	29.3	TLR2 IL18 IL10 CD80 CD4 CCR6
27	nervous system disease	29.2	IL4 IL10 CD8A CD4 CCR6 APOE
28	immune deficiency disease	29.2	TLR2 IL4 IL18 IL10 CD8A CD80
29	disease by infectious agent	29.2	TLR2 IL4 IL18 IL10 CD8A CD4
30	meningoencephalitis	29.2	IL10 CD8A CD4 CCR6 CCL5
31	exanthem	29.1	IL18 IL10 CD8A CD4 CCR6
32	human immunodeficiency virus infectious disease	29.1	IL4 IL10 CD8A CD80 CD4 CCR6
33	peripheral nervous system disease	29.1	IL4 IL10 CD8A CD4 CCR6
34	leukemia, chronic lymphocytic	29.1	IL4 IL10 CD8A CD80 CD4 CCR6
35	keratitis, hereditary	29.0	TLR2 IL10 CD8A CD4 CCR6 ACKR1
36	vaginal disease	29.0	TLR2 IL10 CD8A CD4 CCR6 CCL5
37	listeriosis	29.0	TLR2 TBX21 IL18 IL10 CD8A CD4
38	skin disease	29.0	TLR2 PI3 IL4 IL18 IL10 CD8A
39	eye disease	29.0	IL4 IL10 CD8A CD4 CCR6 CCL5
40	dermatitis	28.9	TLR2 IL4 IL18 IL10 CD8A CD4
41	mollaret meningitis	11.2
42	herpes simplex encephalitis	11.1
43	congenital herpes simplex	11.0
44	neonatal herpes	10.7
45	tropical endomyocardial fibrosis	10.4	IL4 IL10
46	acute cervicitis	10.4	TLR2 IL10
47	acute gonococcal cervicitis	10.4	IL4 IL10
48	spotted fever rickettsiosis	10.4	IL10 CCL5
49	neurosyphilis	10.4	TLR2 IL10
50	cutaneous leishmaniasis	10.4	TLR2 IL4 IL10

Comorbidity relations with Genital Herpes via Phenotypic Disease Network (PDN):

Acute Cystitis

Graphical network of the top 20 diseases related to Genital Herpes:

Sources

Symptoms & Phenotypes for Genital Herpes

Symptoms:

¹²

• fever
• sores

• swollen glands

UMLS symptoms related to Genital Herpes:

fever; pruritus; pelvic pain

MGI Mouse Phenotypes related to Genital Herpes:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.13	APOE CCL5 CCR6 CD4 CD80 CD8A
2	immune system	MP:0005387	10.03	ACKR1 APOE CCL5 CCR6 CD4 CD80
3	digestive/alimentary	MP:0005381	9.92	APOE CD4 IL10 IL18 IL4 TBX21
4	integument	MP:0010771	9.65	APOE CD4 CD8A IFNE IL10 IL18
5	nervous system	MP:0003631	9.4	APOE CCR6 CD4 CD80 CD8A IFI16

Sources

Drugs & Therapeutics for Genital Herpes

Drugs for Genital Herpes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Famciclovir

Approved, Investigational

Phase 4

104227-87-4

3324

Synonyms:

[2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate

1,3-Propanediol, 2-(2-(2-amino-9H-purin-9-yl)ethyl)-, diacetate (ester)

104227-87-4

2-(2-(2-amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate

2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate

2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetate (ester)

2-(2-(2-Amino-9H-purin-9-yl)ethyl)-1,3-propanediol diacetic acid

2-(acetoxymethyl)-4-(2-amino-4,5-dihydro-9H-purin-9-yl)butyl acetate

2-[(acetyloxy)methyl]-4-(2-amino-9H-purin-9-yl)butyl acetate

2-[2-(2-amino-9H-purin-9-yl)ethyl]-1,3-propanediol diacetate

9-(4-acetoxy-3-(acetoxymethyl)but-1-yl)-2-aminopurine

9-(4-Acetoxy-3-(acetoxymethyl)but-1-yl)-2-aminopurine

9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine

9-[4-Acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine

AC-11064

AC1L1FOB

Acetate 2-acetoxymethyl-4-(2-amino-purin-9-yl)-butyl ester

acetic acid 2-acetoxymethyl-4-(2-amino-purin-9-yl)-butyl ester

Acetic acid 2-acetoxymethyl-4-(2-amino-purin-9-yl)-butyl ester

Anti-Farnesyl Rabbit pAb

Bio-0039

BRD-K45033733-001-02-3

BRL 42810

BRL-42810

BSPBio_003489

C14H19N5O4

CHEBI:4974

CHEMBL880

CID3324

CPD000466375

D00317

DB00426

Diacetyl 6-deoxy-9-(4-hydroxy-3-hydroxymethyl-but-1-yl)guanine

famciclovir

Famciclovir

Famciclovir (JAN/USAN/INN)

Famciclovir [USAN:BAN:INN]

Famciclovirum

Famciclovirum [INN-Latin]

Famvir

Famvir (TN)

FCV

HMS1922L09

HMS2051G22

HMS2090G10

HMS2093K12

I03-0096

IN1338

KBio2_000946

KBio2_003514

KBio2_006082

KBio3_002709

KBioGR_001162

KBioSS_000946

LS-120147

MLS000759505

MLS001424115

MolPort-003-666-602

NCGC00095133-01

NCGC00095133-02

NCGC00095133-03

Oravir

S2467_Selleck

SAM001246732

SMR000466375

SPBio_001202

Spectrum_000466

SPECTRUM1505201

Spectrum2_001101

Spectrum3_001675

Spectrum4_000611

Spectrum5_001548

STK623204

UNII-QIC03ANI02

ZINC01530635

Acyclovir

Approved

Phase 4

59277-89-3

2022

Synonyms:

1pwy

2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-6H-purin-6-one

2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one

2-Amino-9-(2-hydroxy-ethoxymethyl)-1,9-dihydro-purin-6-one

2-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one

2-Amino-9-[(2-hydroxyethoxy)methyl]-1,9-dihydro-6H-purin-6-one

2-amino-9-{[(2-hydroxyethyl)oxy]methyl}-1,9-dihydro-6H-purin-6-one

59277-89-3

6H-Purin-6-one,2-amino-1,9-dihydro-9-((2-hydroxyethoxy)mehtyl)

9-((2-Hydroxyethoxy)methyl)guanine

9-(2-Hydroxyethoxy)methylguanine

9-[(2-Hydroxyethoxy)- methyl]guanine

9-[(2-Hydroxyethoxy)methyl]guanine

9-[(2-Hydroxyethoxy)-methyl]guanine

9-Hyroxyethoxymethylguanine

9-HYROXYETHOXYMETHYLGUANINE

A 4669

A1562_SIGMA

A4669_SIGMA

Abello brand OF aciclovir

AC-11038

AC1L1CR6

AC2

Aci sanorania

Acic

Aciclobeta

Aciclostad

Aciclovier

Aciclovir

Aciclovir (JAN/INN)

Aciclovir abello brand

Aciclovir alcon brand

Aciclovir alonga

Aciclovir alphapharm brand

Aciclovir amrad brand

Aciclovir azupharma brand

Aciclovir betapharm brand

Aciclovir britisfarma brand

Aciclovir clonmel brand

Aciclovir CT-arzneimittel brand

Aciclovir dermapharm brand

Aciclovir fabrigen brand

Aciclovir fustery brand

Aciclovir granules

Aciclovir grin brand

Aciclovir grünenthal brand

Aciclovir hexal brand

Aciclovir isis brand

Aciclovir kendrick brand

Aciclovir lichtenstein brand

Aciclovir liomont brand

Aciclovir mann brand

Aciclovir menarini brand

Aciclovir niddapharm brand

Aciclovir novag brand

Aciclovir novartis brand

Aciclovir ophthalmic oinment

Aciclovir pensa brand

Aciclovir pisa brand

Aciclovir rentschler brand

Aciclovir sanorania

Aciclovir sanorania brand

Aciclovir stada brand

Aciclovir tablets

Aciclovir tad brand

Aciclovir ursapharm brand

Aciclovir von CT

Aciclovir warner-lambert brand

Aciclovir wellcome brand

Aciclovir wolff brand

Aciclovir yamanouchi brand

Aciclovir zyma brand

Aciclovir, Acycloguanosine, Zovirax, Acyclovir

Aciclovir-sanorania

Aciclovirum

Aciclovirum [INN-Latin]

Aciclovirum [Latin]

Acifur

Acipen solutab

Aci-sanorania

Acivir

Activir

ACV & Pluronic F-68

Acyclo V

AcycloFoam

Acycloguanosine

Acyclo-V

acyclovir

Acyclovir

Acyclovir & Pluronic F-68

Acyclovir (USP)

Acyclovir [USAN]

Acyclovir Lauriad

Acyclovir sodium

Acyclovir-side chain-2-3H

AKOS000656213

Alcon brand OF aciclovir

Alonga brand OF aciclovir

Alonga brand OF aciclovir sodium salt

Alonga, aciclovir

Alphapharm brand OF aciclovir

Alti-Acyclovir

Amrad brand OF aciclovir

Antiherpes creme

Avirax

Azupharma brand OF aciclovir

BAS 00485787

BB_NC-0569

Betapharm brand OF aciclovir

BIDD:GT0646

B-LF& ACV

Bovine lactoferrin & 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one

BPBio1_000014

Britisfarma brand OF aciclovir

Britisfarma brand OF aciclovir sodium salt

BSPBio_000012

BSPBio_003348

Bull brand OF aciclovir

BW-248U

BW-248-U

BW-248U74

C06810

C8H11N5O3

CAS-59277-89-3

CCRIS 1953

CHEBI:2453

CHEMBL184

Cicloferon

CID2022

Clonmel brand OF aciclovir

Clonorax

CPD000058225

CT Arzneimittel brand OF aciclovir

CT-Arzneimittel brand OF aciclovir

Curasan brand OF aciclovir sodium salt

Cusiviral

D00222

DB00787

Dermapharm brand OF aciclovir

DivK1c_000185

DRG-0008

EINECS 261-685-1

EU-0100037

Fabrigen brand OF aciclovir

FT-0082883

Fustery brand OF aciclovir

Genvir

Glaxo wellcome brand OF aciclovir

Glaxo wellcome brand OF aciclovir sodium salt

Grin brand OF aciclovir

Grünenthal brand OF aciclovir

Grünenthal brand OF aciclovir sodium salt

Hascovir

Herpetad

Herpofug

Herpotern

Herpoviric

Hexal brand OF aciclovir

Hexal brand OF aciclovir sodium salt

HMS1568A14

HMS1922E08

HMS2090G09

HMS500J07

HSDB 6511

I01-1122

IDI1_000185

InChI=1/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15

Isavir

Isis brand OF aciclovir

KBio1_000185

KBio2_002219

KBio2_004787

KBio2_007355

KBio3_002850

KBioGR_000889

KBioSS_002219

Kendrick brand OF aciclovir

Laciken

Lichtenstein brand OF aciclovir

Liomont brand OF aciclovir

Lopac0_000037

Lopac-A-4669

LS-127209

Mann brand OF aciclovir

Mapox

Maynar

Menarini brand OF aciclovir

Menarini brand OF aciclovir sodium salt

Milavir

MLS000069633

MolPort-000-768-994

MolPort-001-889-834

NCGC00015061-01

NCGC00015061-02

NCGC00015061-03

NCGC00015061-04

NCGC00015061-10

NCGC00022426-03

NCGC00093555-01

NCGC00093555-02

NCGC00093555-03

NCGC00093555-04

NCGC00167756-01

Niddapharm brand OF aciclovir

NINDS_000185

Novag brand OF aciclovir

Novartis brand OF aciclovir

NSC 645011

NSC645011

Opthavir

Parke davis brand OF aciclovir

Pensa brand OF aciclovir

Pensa brand OF aciclovir sodium salt

Pharma investi brand OF aciclovir

Pisa brand OF aciclovir

Prestwick_6

Prestwick0_000086

Prestwick1_000086

Prestwick2_000086

Prestwick3_000086

Rentschler brand OF aciclovir

Rentschler brand OF aciclovir sodium salt

S1807_Selleck

SAM002589967

Sanorania brand OF aciclovir

Sanorania brand OF aciclovir sodium salt

Sitavig

SMP1_000007

SMR000058225

Sodium, acyclovir

Solutab, acipen

SPBio_001466

SPBio_001951

Spectrum_001739

SPECTRUM1503603

Spectrum2_001563

Spectrum3_001874

Spectrum4_000225

Spectrum5_001093

Stada brand OF aciclovir

STK796771

Supraviran

TAD brand OF aciclovir

TL8003779

UNII-X4HES1O11F

Ursapharm brand OF aciclovir

Viclovir

Vipral

Virax puren

Virax-puren

ViraxPuren

Virherpes

Virmen

Virolex

Viropump

Virorax

Virupos

Virzin

W-248-U

Warner lambert brand OF aciclovir

Warner wellcome brand OF aciclovir

Warner-lambert brand OF aciclovir

Wellcome 248u

Wellcome brand OF aciclovir

Wellcome brand OF aciclovir sodium salt

Wellcome248u

Wellcome-248u

Wellcome-248U

Wolff brand OF aciclovir

Yamanouchi brand OF aciclovir

ZINC01530555

Zoliparin

Zovir

Zovirax

Zovirax (TN)

Zovirax for injection

Zovirax Oral Acyclovir (ACV) Suspension

Zyclir

Zyma brand OF aciclovir

Melatonin

Approved, Nutraceutical, Vet_approved

Phase 4

73-31-4

896

Synonyms:

{N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} acetamide

{N-[2-(5-methoxyindol-3-yl)ethyl]-} acetamide

0E2B08C1-B325-45B1-8939-6F9081EFDFA4

3-(2-Acetamidoethyl)-5-methoxyindole

4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID

5-22-12-00042 (Beilstein Handbook Reference)

5-methoxy-N-acetyltryptamine

5-Methoxy-N-acetyltryptamine

73-31-4

A4039/0172195

AB00053279

AC1L1A9Q

AC1Q4F1W

AC1Q4F1X

Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}

Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}

Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- (9CI)

Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI)

Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI)

AKOS000276269

BAS 01281092

BIDD:ER0618

Bio-0635

BPBio1_000590

BRD-K97530723-001-07-6

BRN 0205542

BSPBio_000536

BSPBio_003006

C01598

CAS-73-31-4

CCRIS 3472

CHEBI:16796

CHEMBL45

ChemDiv2_003916

CID896

Circadin

D008550

D08170

DB01065

DB08189

DivK1c_000353

EINECS 200-797-7

EU-0100787

HMS1380B22

HMS1569K18

HMS1921E04

HMS2089F09

HMS501B15

HSCI1_000400

HSDB 7509

I05-0076

I10-0345

IDI1_000353

IDI1_002631

IN1244

KBio1_000353

KBio2_000665

KBio2_003233

KBio2_005801

KBio3_002226

KBioGR_000591

KBioSS_000665

L001261

Lopac0_000787

Lopac-M-5250

LS-1623

M 5250

M1105

M-1200

M-1250

M5250_SIGMA

Melapure

Mela-T

Melatol

Melatonex

Melatonex, Melatonin

Melatonin

Melatonin (synth.) standard-grade

Melatonin (synth.) ultra-pure

Melatonina

Melatonina (TN)

Melatonine

Mélatonine

Melovine

ML1

MLS000859594

MLS001055382

MLS001240204

MolPort-000-737-883

MT6

N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide

N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide

N-(2-(5-Methoxyindol-3-yl)ethyl)-acetamide

N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide

N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide

N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-acetamide

N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide

N-[2-(5-methoxyindol-3-yl)ethyl]acetamide

N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide

N-[2-(5-Methoxyindol-3-yl)ethyl]-acetamide

N-acetyl-5-methoxy-tryptamine

N-Acetyl-5-methoxytryptamine

N-Acetyl-5-methoxy-tryptamine

N-Acetyl-5-methoxy-tryptamine melatonine

Nature'S Harmony

NCGC00015680-01

NCGC00015680-02

NCGC00015680-03

NCGC00015680-06

NCGC00015680-13

NCGC00090727-01

NCGC00090727-02

NCGC00090727-03

NCGC00090727-04

NCGC00090727-05

NCGC00090727-06

NCGC00090727-07

NCGC00090727-08

NCGC00090727-09

NCI60_004378

Night Rest

NINDS_000353

NMR/14327425

NSC 113928

NSC113928

NSC56423

Oprea1_104553

Oprea1_814234

Pineal Hormone

Posidorm

Prestwick_312

Prestwick0_000458

Prestwick1_000458

Prestwick2_000458

Prestwick3_000458

PREVENTION 1 (MELATONIN) (PREVENTION 1)

PREVENTION 2 (MELATONIN)

PREVENTION 3 (MELATONIN)

PREVENTION 4 (MELATONIN)

PREVENTION 5 (MELATONIN)

Regulin

Revital Melatonin

Rx Balance

S1204_Selleck

SDCCGMLS-0065812.P001

SDCCGMLS-0065812.P002

Sleep Right

SMP2_000309

SMR000326666

SPBio_001527

SPBio_002475

Spectrum_000185

SPECTRUM1500690

Spectrum2_001344

Spectrum3_001393

Spectrum4_000066

Spectrum5_001745

STK386880

TNP00300

UNII-JL5DK93RCL

Vivitas

WLN: T56 BMJ D2MV1 GO1

ZINC00057060

Antioxidants

Phase 4

Anti-Infective Agents

Phase 4

Antiviral Agents

Phase 4

valacyclovir

Phase 4

Halofantrine

Approved

Phase 3

69756-53-2

37393

Synonyms:

(+-)-Halofantrine hydrochloride

(1)-Halofantrine

1-(1,3-Dichloro-6-trifluoromethyl-9-phenanthryl)-3-(di-n-butylamino)propanol hydrochloride

1-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-di(n-butyl)aminopropanol HCl

1-(1,3-Dichloro-6-trifluoromethyl-9-phenanthryl)-3-di(N-butyl)aminopropanol HCL

1,3-Dichloro-.alpha.-[2-(dibutylamino)ethyl]-6- (trifluoromethyl)-9-phenathrenemethanol

1,3-Dichloro-.alpha.-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrene-methanol

1,3-Dichloro-6-trifluoromethyl-9-(3-(dibutylamino)-1-hydroxypropyl)phenanthrene HCl

1,3-Dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-9-phenanthrenemethanol hydrochloride

1,3-Dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)phenanthren-1-methanol hydrochloride

106927-11-1

3-(Dibutylamino)-1-(1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl)propan-1-ol hydrochloride

3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol

3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol hydrochloride

36167-63-2

66051-63-6

69756-53-2

9-(3-(dibutylamino)-1-hydroxypropyl)-1,3-dichloro-6-(trifluoromethyl)phenanthrene hydrochloride

9-Phenanthrenemethanol, 1,3-dichloro-.alpha.-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-(1)

9-Phenanthrenemethanol, 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-, hydrochloride

9-Phenanthrenemethanol, 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-,hydrochloride

AB00514703

AC1L1XMK

AC1L1XMN

AC1Q4K45

AC-481

BPBio1_001366

BSPBio_001241

C26H30Cl2F3NO.HCl

CHEBI:252728

CHEMBL1107

CHEMBL1200901

CID37392

CID37393

D02485

DB01218

dl-WR 171669

EINECS 252-895-4

FT-0082696

Halfan

Halfan (TN)

Halofantrina

Halofantrine

Halofantrine [USAN]

Halofantrine HCl

Halofantrine hydrochloride

HALOFANTRINE HYDROCHLORIDE

Halofantrine hydrochloride (USAN)

Halofantrine Hydrochloride [USAN]

Halofantrino

Halofantrino [Spanish]

Halofantrinum

HMS1571O03

I14-2822

LS-102675

LS-187198

MLS002154111

MolPort-005-940-418

MolPort-005-942-171

NCGC00179250-01

NCI60_002593

Prestwick0_001031

Prestwick1_001031

Prestwick2_001031

Prestwick3_001031

SK&F-102866

SMR001233418

SPBio_003092

UNII-H77DL0Y630

UNII-Q2OS4303HZ

WR 171,699

WR 171669

WR-171,669

WR-171669

WR-171699

Aluminum sulfate

Approved

Phase 3

10043-01-3

Vaccines

Phase 3

polysaccharide-K

Phase 3

Immunologic Factors

Phase 3

Protective Agents

Phase 3

interferons

Phase 3

Antibiotics, Antitubercular

Phase 3

Monophosphoryl lipid A

Phase 3

Radiation-Protective Agents

Phase 3

Adjuvants, Immunologic

Phase 3

Anti-Bacterial Agents

Phase 3

Lecithin

Experimental

Phase 2

8002-43-5

Pritelivir

Investigational

Phase 2

348086-71-5

Anti-Retroviral Agents

Phase 2

Antibodies

Phase 2

Immunoglobulins

Phase 2

Antibodies, Monoclonal

Phase 2

Interventional clinical trials:

(show top 50) (show all 63)

#	Name	Status	NCT ID	Phase	Drugs
1	Effects of Melatonin in the Treatment of Genital Herpes	Unknown status	NCT03831165	Phase 4	Acyclovir 400 MG
2	An International, Randomized, Double-Blind, Placebo-Controlled, Multicenter, 6-Month Study of the Efficacy and Safety of Valtrex 1g QD vs. Placebo for the Suppression of HSV-2 Genital Herpes in Newly Diagnosed Immunocompetent Patients	Completed	NCT00158860	Phase 4	Valaciclovir;Placebo
3	Valacyclovir for the Suppression of HSV-2 Viral Shedding in HSV-2 Seropositive Individuals With No History of Symptomatic GH	Completed	NCT00116844	Phase 4	Valaciclovir;Placebo
4	A Randomized, Cross-Over Study to Evaluate the Suppressive Effect of High-Dose Acyclovir Versus Once Daily Valacyclovir on Herpes Simplex Virus Type 2 Genital Shedding in Herpes Simplex Virus-2 Seropositive Adults	Completed	NCT00362297	Phase 4	acyclovir;valacyclovir
5	A Randomized, Multicenter, Double-blind Study to Compare the Efficacy of Single-day Treatment (1000 mg b.i.d.) With Famciclovir Compared to That of Placebo in Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Immunocompetent Black Patients	Completed	NCT00477334	Phase 4	Famciclovir;Placebo
6	A Study to Determine the Safety and Efficacy of Famciclovir in the Episodic and Suppressive Treatment of Recurrent Genital Herpes (RGH). The Study Will Also Evaluate Quality of Life and Patient Satisfaction	Completed	NCT00219310	Phase 4	Famciclovir
7	A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding	Completed	NCT00129818	Phase 4	Famciclovir
8	A Randomized, Cross-Over Study to Evaluate the Suppressive Effect of High-Dose Valacyclovir Versus Once Daily Valacyclovir on Herpes Simplex Virus Type 2 Genital Shedding in Herpes Simplex Virus-2 Seropositive Adults	Completed	NCT01346475	Phase 4	valacyclovir;Valacyclovir
9	A Randomized, Cross-Over Study to Evaluate the Suppressive Effect of Acyclovir on Rapidly Cleared Herpes Simplex Virus Type 2 Genital Reactivation Episodes in Herpes Simplex Virus-2 Seropositive Adults	Completed	NCT00723229	Phase 4	acyclovir
10	A Randomized, Open-label, Crossover Trial of the Effect of Dosing of Daily HSV-2 Suppressive Therapy on HSV Reactivation and Plasma HIV-1 Levels Among HIV-1/ HSV-2 Co-infected Persons	Completed	NCT00527618	Phase 4	valacyclovir;acyclovir
11	The Effect of Valacyclovir 1g Once Daily on HSV-2 Viral Shedding in Subjects Newly Diagnosed With Genital Herpes Infection	Completed	NCT00306293	Phase 4	valacyclovir
12	Randomized, Placebo-controlled, Double-blind Study to Evaluate the Efficacy of 2LHERP® in Patients With Recurrent Genital Herpes Infections	Recruiting	NCT04235322	Phase 4	2LHERP®;Placebo
13	Effect of Suppressive Therapy on Behavioral Determinants of HSV-2 Transmission	Terminated	NCT00495716	Phase 4	acyclovir;acyclovir
14	An International, Randomized, Double-Blind, Placebo-Controlled Study of Valaciclovir for the Suppression and Episodic Treatment of Genital HSV Infection in HIV-Infected Persons With CD4+ Lymphocyte Count <100 Cells/mm3.	Terminated	NCT00079911	Phase 4	valacyclovir hydrochloride
15	Trial of Male Circumcision: HIV, STD and Behavioral Effects in Men, Women and the Community	Unknown status	NCT00124878	Phase 3
16	An International, Randomized, Double-Blind, Placebo-Controlled Study of Valacyclovir for the Suppression of Recurrent Ano-Genital HSV Infections in HIV-Infected Subjects	Unknown status	NCT00005663	Phase 3	Valacyclovir hydrochloride
17	Efficacy and Safety of Oral Famciclovir in Patients With Active Recurrent Genital Herpes	Completed	NCT00171990	Phase 3	Famciclovir
18	A Multicenter, Randomized, Double-blind Study to Compare the Efficacy and Safety of Patient-initiated Famciclovir 1000 mg b.i.d. x 1 Day to Valacyclovir 500 mg b.i.d. x 3 Days in Immunocompetent Adults With Recurrent Genital Herpes	Completed	NCT00306787	Phase 3	Famciclovir;Valacyclovir;Placebo matching famciclovir;Placebo matching valacyclovir
19	Phase III Randomized Placebo-Controlled Trial of HSV-2 Suppression to Prevent HIV Transmission Among HIV-Discordant Couples	Completed	NCT00194519	Phase 3	Generic acyclovir;Placebo
20	Safety of SmithKline Beecham Biologicals' Herpes Simplex Candidate Vaccine (gD2t) With MPL & Its Efficacy to Prevent Genital Herpes Disease in HSV Positive or Negative Consorts of Subjects With Genital Herpes Disease	Completed	NCT00699764	Phase 3
21	A Prospective, Randomized, Multicenter Study of the Efficacy and Safety of Famciclovir 125 mg Comparing to Aciclovir 200 mg in Patients With Active Recurrent Genital Herpes	Completed	NCT01281007	Phase 3	Famciclovir;Aciclovir
22	A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Acyclovir for the Reduction of HIV Acquisition Among High-Risk HSV-2 Seropositive, HIV Seronegative Individuals	Completed	NCT00076232	Phase 3	Acyclovir;Acyclovir placebo
23	An International Multi-centre, Randomised, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of 0.5% and 2% PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection	Completed	NCT00262106	Phase 3	PRO 2000/5;Placebo
24	A Double-Blind, Randomized, Controlled Phase III Study to Assess the Prophylactic Efficacy and Safety of gD-Alum/MPL Vaccine in the Prevention of Genital Herpes Disease in Young Women Who Are HSV-1 and -2 Seronegative	Completed	NCT00057330	Phase 3
25	Study to Evaluate the Safety of GSK Biologicals' Herpes Simplex Candidate Vaccine (gD2t) With MPL in HSV Seropositive or Seronegative Subjects Without Genital Herpes Disease	Completed	NCT00698568	Phase 3
26	Effect of Safe Male Circumcision on Incidence of Infection by HIV, HSV-2 and of Genital Ulceration	Terminated	NCT00122525	Phase 3
27	Efficacy of an HSV2 Genital Herpes Suppressive Treatment on HIV and HSV2 Genital Shedding Among Co-Infected Patients Receiving or Not Antiretroviral Drugs	Completed	NCT00158509	Phase 2	Valacyclovir
28	A Phase 2a Multicenter, Double-blinded, Randomized Trial to Evaluate The Effect of HerpV on Viral Shedding in Adults With Recurrent Genital Herpes	Completed	NCT01687595	Phase 2	HerpV and QS-21;Placebo
29	A Randomized, Double-Blind Study to Evaluate a New Formulation of GEN-003 in Subjects With Genital HSV-2 Infection	Completed	NCT02515175	Phase 2	Placebo
30	Rollover Trial for Placebo Subjects Previously Enrolled Into GEN-003-002 - Randomized, Double-Blind, Factorial Study to Compare the Safety and Efficacy of Combinations of GEN-003 and Matrix-M2 in Subjects With Genital HSV-2	Completed	NCT02300142	Phase 2
31	A Phase I/IIa, Randomized, Double-blind, Dose-ranging, Placebo-controlled Study of the Safety and Immunogenicity of a HSV-2 Vaccine Containing Matrix M-2 Adjuvant in Individuals With Documented Genital HSV-2 Genital Infection	Completed	NCT01667341	Phase 1, Phase 2
32	A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation, Phase 1/2 Trial to Evaluate the Safety and Efficacy of Herpes Simplex Virus, Type 2 Therapeutic DNA Vaccines in Symptomatic HSV-2-Seropositive Adults	Completed	NCT02030301	Phase 1, Phase 2
33	A Randomized, Double-Blind, Factorial Study to Compare the Safety and Efficacy of Varying Combinations of GEN-003 and Matrix-M2 in Subjects With Genital HSV-2 Infection	Completed	NCT02114060	Phase 2
34	A Phase II, Dose-Finding Study With ASP2151 in Subjects With Recurrent Episodes of Genital HErpes	Completed	NCT00486200	Phase 2	ASP2151;valacyclovir;Placebo
35	A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial to Evaluate the Safety and Efficacy of Herpes Simplex Virus, Type 2 (HSV-2) Therapeutic DNA Vaccine in Adults With Symptomatic Genital HSV-2 Infection	Completed	NCT02837575	Phase 2
36	Anti-Herpetic Treatment Associated With Syndromic Management of Genital Ulcer in Africa: Clinical and Biological Evaluation on HIV-1 and HSV-2 Shedding (ANRS 1212)	Completed	NCT00158483	Phase 2	Acyclovir (ACV)
37	A Randomized, Double-Blind, Placebo-Controlled Trial of Acyclovir Prophylaxis Versus Placebo Among HIV-1/HSV-2 Co-Infected Individuals in Uganda	Completed	NCT00405821	Phase 2	Acyclovir;Placebo
38	Assessment of Local Retention and Duration of Activity of SPL7013 Following Vaginal Application of 3% SPL7013 Gel (VivaGel) in Healthy Volunteers	Completed	NCT00740584	Phase 1, Phase 2	3% SPL7013 Gel (VivaGel)
39	Safety and Efficacy of 4 Investigational HSV 2 Vaccines Administered by Intramuscular Route in Adults With Recurrent Genital Herpes Caused by HSV 2	Active, not recruiting	NCT04222985	Phase 1, Phase 2
40	A Randomized, Double-Blind, Double-Dummy Phase II Study of Single Dose HDIT101 Versus Standard of Care Valaciclovir in Patients With Chronic Recurrent Anogenital HSV-2 Infection	Active, not recruiting	NCT04165122	Phase 2	Valaciclovir;Valaciclovir placebo
41	A Two-Stage, Randomized, Double-Blind, Dose-Ranging, Phase 2 Trial to Evaluate the Safety and Efficacy of UB-621 on HSV Shedding in Adults With Recurrent Genital HSV-2 Infection.	Not yet recruiting	NCT03595995	Phase 2
42	A Randomized, Single-blind, Dose-selected Phase II Trial to Evaluate the Safety and Efficacy of UB-621 in Adults With Recurrent Genital HSV-2 Infection	Not yet recruiting	NCT04714060	Phase 2
43	A Phase II Open-label, Intra-individual Controlled, Single-center Study to Investigate the Efficacy, Safety and Tolerability of a Polyethylene Glycol-formulation and the Viral Shedding in Patients Suffering From Genital Herpes	Terminated	NCT01765114	Phase 2	PEG-Formulation
44	A Randomized, Placebo-controlled, Double-blind Study to Assess the Efficacy and Safety of a Maintenance Dose of GEN-003 in Subjects With Genital Herpes Infection	Terminated	NCT03146403	Phase 2
45	A Double-blind, Double Dummy, Randomized Crossover Trial to Compare the Effect of "AIC316 (Pritelivir)" 100 mg Once Daily Versus Valacyclovir 500 mg Once Daily on Genital HSV Shedding in HSV-2 Seropositive Adults.	Terminated	NCT01658826	Phase 2	AIC316;Valacyclovir
46	A Phase 1 Trial Evaluating Safety, Tolerability and Immune Response of AG-707 Compared to Placebo in HSV-2 Seropositive Patients	Completed	NCT00231049	Phase 1	AG-707
47	A Phase I, Two-Center, Open-Label, Dose-Escalating Study to Investigate the Safety, Tolerability and Immunogenicity of pPJV7630, a Therapeutic DNA Vaccine for Herpes Simplex Virus Type 2 (HSV-2), in Patients With Recurrent Genital Herpes Caused by HSV-2	Completed	NCT00274300	Phase 1
48	A Double-Blind, Placebo-Controlled Single Dose Escalating Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP2151 in Healthy Male Subjects, Followed by an Open, Two-Period Crossover Study to Assess the Effect of Fed Conditions on the Safety, Tolerability and Pharmacokinetics of ASP2151	Completed	NCT02852876	Phase 1	ASP2151;Placebo
49	A Long-term Follow-up Study of Efficacy and Immunogenicity of GEN-003 in Subjects With Genital Herpes Simplex Virus Type 2 (HSV-2) Infection	Completed	NCT02910284
50	Serologic Assays for the Diagnosis of Herpes Simplex Virus Type 2: Development of Testing Strategies	Completed	NCT01112956

Search NIH Clinical Center for Genital Herpes

Inferred drug relations via UMLS ⁷⁰ / NDF-RT ⁵¹ :

Acyclovir

Acyclovir Sodium

famciclovir

Foscarnet

Foscarnet Sodium Hexahydrate

Interferon Alfa-2b

valacyclovir

Valacyclovir hydrochloride

Cochrane evidence based reviews: herpes genitalis

Sources

Genetic Tests for Genital Herpes

Sources

Anatomical Context for Genital Herpes

The Foundational Model of Anatomy Ontology organs/tissues related to Genital Herpes:

¹⁹

Genital System, Rectum

MalaCards organs/tissues related to Genital Herpes:

⁴⁰

Skin, Cervix, T Cells, Nk Cells, Placenta, Myeloid, B Cells

Sources

Publications for Genital Herpes

Articles related to Genital Herpes:

(show top 50) (show all 3301)

#	Title	Authors	PMID	Year
1	Herpes Simplex Virus 2 Counteracts Neurite Outgrowth Repulsion during Infection in a Nerve Growth Factor-Dependent Manner. ⁴²	Kropp KA...Viejo-Borbolla A	32669337	2020
2	Phosphoregulation of a Conserved Herpesvirus Tegument Protein by a Virally Encoded Protein Kinase in Viral Pathogenicity and Potential Linkage between Its Evolution and Viral Phylogeny. ⁴²	Shibazaki M...Kawaguchi Y	32611749	2020
3	High Preventive Effect of G2-S16 Anionic Carbosilane Dendrimer against Sexually Transmitted HSV-2 Infection. ⁴²	Rodriguez-Izquierdo I...Munoz-Fernandez MA	32605185	2020
4	Protection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HSV-1-seronegative guinea pigs. ⁶¹ ⁵⁴	Hoshino Y...Cohen JI	19702506	2009
5	Placebo-controlled trial of vaccination with recombinant glycoprotein D of herpes simplex virus type 2 for immunotherapy of genital herpes. ⁶¹ ⁵⁴	Straus SE...Adair SF	7911177	1994
6	Passive immunization of the vagina protects mice against vaginal transmission of genital herpes infections. ⁵⁴ ⁶¹	Whaley KJ...Cone RA	8158042	1994
7	Estimates of the Prevalence and Incidence of Genital Herpes, United States, 2018. ⁶¹	Spicknall IH...Torrone EA	33492103	2021
8	Sexually Transmitted Infections Among US Women and Men: Prevalence and Incidence Estimates, 2018. ⁶¹	Kreisel KM...Weinstock HS	33492089	2021
9	The Estimated Direct Lifetime Medical Costs of Sexually Transmitted Infections Acquired in the United States in 2018. ⁶¹	Chesson HW...Gift TL	33492093	2021
10	Genital Mycoplasma, Shigellosis, Zika, Pubic Lice, and Other Sexually Transmitted Infections: Neither Gone Nor Forgotten. ⁶¹	Torrone EA...Weinstock HS	33492101	2021
11	Lifetime Medical Costs of Genital Herpes in the United States: Estimates From Insurance Claims. ⁶¹	Eppink ST...Chesson HW	33492102	2021
12	Vulvovaginal candidiasis in Iran: A systematic review and meta-analysis on the epidemiology, clinical manifestations, demographic characteristics, risk factors, etiologic agents and laboratory diagnosis. ⁶¹	Sasani E...Hashemi SJ	33741400	2021
13	Serum and Cervicovaginal Fluid Antibody Profiling in Herpes Simplex Virus (HSV) Seronegative Recipients of the HSV529 Vaccine. ⁶¹	Wang K...Cohen JI	33718970	2021
14	Genital HSV-1 DNA detection is associated with a low inflammatory profile in HIV-uninfected South African women. ⁶¹	Mtshali A...Liebenberg LJP	32848051	2021
15	Update: Sexually Transmitted Infections, Active Component, U.S. Armed Forces, 2012-2020. ⁶¹		33773568	2021
16	Treatment of genital herpes using olive leaf extract. ⁶¹	Lorzadeh N...Kazemirad N	33598284	2021
17	Analysis of the clinical trial results of the flavonoid effects on some cellular immunity indicators in children and adults. ⁶¹	Beketova G...Yashchenko L	33713093	2021
18	Changing Demography of Genital Chlamydia, Gonorrhea, Genital Herpes, Condyloma, and Syphilis Infections in Japan. ⁶¹	Yoshikura H	32611973	2021
19	Age- and Sex-Related Differences in Morbidities of Sexually Transmitted Diseases in Children. ⁶¹	Hino Y...Tokumaru O	33445644	2021
20	Ovariectomized mice and postmenopausal women exhibit analogous loss of genital epithelial integrity. ⁶¹	Quispe Calla NE...Cherpes TL	33427560	2021
21	[Brazilian Protocol for Sexually Transmitted Infections 2020: infections that cause genital ulcers]. ⁶¹	Ramos MC...Lannoy LH	33729413	2021
22	Recent Advances in Nanosystems and Strategies for Vaginal Delivery of Antimicrobials. ⁶¹	Chindamo G...Gallarate M	33530510	2021
23	TRIM26 Facilitates HSV-2 Infection by Downregulating Antiviral Responses through the IRF3 Pathway. ⁶¹	Dhawan T...Kaushic C	33419081	2021
24	Herpes Simplex Virus Serotyping in Pregnant Women With a History of Genital Herpes and an Outbreak in the Third Trimester of Pregnancy: A Cost-Effectiveness Analysis. ⁶¹	Chatroux IC...Caughey AB	33278294	2021
25	Does bacillus Calmette-Guérin vaccine prevent herpes simplex virus recurrences? A systematic review. ⁶¹	Pittet LF...Curtis N	32975011	2021
26	Genital herpes - diagnosis, treatments, attitudes and response to disclosure amongst members of the UK Herpes Viruses Association. ⁶¹	Nicholson M...O'Farrell N	33115318	2021
27	Subclinical Genital Herpes Shedding in HIV/Herpes Simplex Virus 2-Coinfected Women during Antiretroviral Therapy Is Associated with an Increase in HIV Tissue Reservoirs and Potentially Promotes HIV Evolution. ⁶¹	Stinn T...Bull ME	33028713	2020
28	Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans. ⁶¹	Hait AS...Mogensen TH	33310865	2020
29	Protection against herpes simplex virus type 2 infection in a neonatal murine model using a trivalent nucleoside-modified mRNA in lipid nanoparticle vaccine. ⁶¹	LaTourette PC...Friedman HM	33041105	2020
30	An adult case of parainfectious optic neuritis associated with genital herpes simplex virus type 2 infection. ⁶¹	Shima T...Tsujino A	32937275	2020
31	Hemophagocytic Lymphohistiocytosis as the Presenting Manifestation of Relapsed Classic Hodgkin's Lymphoma in the Presence of Concurrent Human Immunodeficiency Virus, Genital Herpes, Epstein-Barr Virus and Mycobacterium Avium Complex Infection. ⁶¹	Siddiqui RS...Bashir T	33364090	2020
32	Prevalence of co-infections with other sexually transmitted infections in patients newly diagnosed with anogenital warts in Guangzhou, China. ⁶¹	Wang L...Yang L	32842906	2020
33	Genotype-Informed Versus Empiric Management Of VirEmia (GIVE MOVE): study protocol of an open-label randomised clinical trial in children and adolescents living with HIV in Lesotho and Tanzania. ⁶¹	Brown JA...Labhardt ND	33076866	2020
34	[Herpes simplex virus and central nervous system infections: encephalitis, meningitis, myelitis]. ⁶¹	Rozenberg F	33111702	2020
35	ACOG Practice Bulletin No. 220: Management of Genital Herpes in Pregnancy. ⁶¹	Urato AC	32976371	2020
36	Risk to patients, risk to clinicians: a three-site audit of the documentation of counselling in first episode genital herpes. ⁶¹	Cornish E...Patel R	32915699	2020
37	Impact evaluation of scripted lesson plans for HIV-related content in a life orientation curriculum: results from two provinces in South Africa. ⁶¹	Speizer IS...Durno D	33054742	2020
38	Herpes simplex virus type 2 trivalent protein vaccine containing glycoproteins C, D and E protects guinea pigs against HSV-1 genital infection. ⁶¹	Egan K...Awasthi S	32347775	2020
39	Herpes Simplex Virus: Epidemiology, Diagnosis, and Treatment. ⁶¹	Cole S	32762854	2020
40	Impact of a single-age cohort human papillomavirus vaccination strategy in Catalonia, Spain: Population-based analysis of anogenital warts in men and women. ⁶¹	Brotons M...Bruni L	32565118	2020
41	Use of the Guinea pig model of genital herpes to evaluate vaccines and antivirals: Review. ⁶¹	Bernstein DI	32544409	2020
42	Viral ribonucleotide reductase attenuates the anti-herpes activity of acyclovir in contrast to amenamevir. ⁶¹	Shiraki K...Yoshida Y	32569704	2020
43	[Intracellular transport of Alphaherpesvirinae]. ⁶¹	Lippe R	32795979	2020
44	Epidemiological Impact of Novel Preventive and Therapeutic HSV-2 Vaccination in the United States: Mathematical Modeling Analyses. ⁶¹	Ayoub HH...Abu-Raddad LJ	32650385	2020
45	Vaccines against Genital Herpes: Where Are We? ⁶¹	Kim HC...Lee HK	32727077	2020
46	The Mutation of the Genes Related to Neurovirulence in HSV-2 Produces an Attenuated Phenotype in Mice. ⁶¹	Liu L...Li Q	32708847	2020
47	; THE ADVANCEMENTS IN TREATMENT OF HIV-INFECTED PATIENTS WITH HERPETIC INFECTION. ⁶¹	Sokolenko M...Andrushchak M	32965250	2020
48	Herpes simplex virus type 1 in Europe: systematic review, meta-analyses and meta-regressions. ⁶¹	Yousuf W...Abu-Raddad L	32675066	2020
49	Unilateral inguinal lymphadenitis caused by Yersinia pseudotuberculosis. A case report. ⁶¹	Iwata K...Naito A	32386928	2020
50	Contriving a chimeric polyvalent vaccine to prevent infections caused by herpes simplex virus (type-1 and type-2): an exploratory immunoinformatic approach. ⁶¹	Hasan M...Hasan MN	31328668	2020

Sources

Genes for Genital Herpes

Genes related to Genital Herpes (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ACKR1	Atypical Chemokine Receptor 1 (Duffy Blood Group)	Protein Coding	22.87	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	7911177 19702506 8158042
2	TLR2	Toll Like Receptor 2	Protein Coding	12.67	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	12.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	IL4	Interleukin 4	Protein Coding	12.14	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	IL10	Interleukin 10	Protein Coding	12.1	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	IFI16	Interferon Gamma Inducible Protein 16	Protein Coding	11.66	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	IL18	Interleukin 18	Protein Coding	11.54	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	PI3	Peptidase Inhibitor 3	Protein Coding	11.1	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	APOE	Apolipoprotein E	Protein Coding	11.02	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	TBX21	T-Box Transcription Factor 21	Protein Coding	11	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	CD80	CD80 Molecule	Protein Coding	10.95	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	IFNE	Interferon Epsilon	Protein Coding	10.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.87	DISEASES inferred ¹⁵ ¹⁵
14	CD4	CD4 Molecule	Protein Coding	7.4	DISEASES inferred ¹⁵
15	NECTIN1	Nectin Cell Adhesion Molecule 1	Protein Coding	7.34	DISEASES inferred ¹⁵
16	CD8A	CD8a Molecule	Protein Coding	7.06	DISEASES inferred ¹⁵
17	TNFRSF14	TNF Receptor Superfamily Member 14	Protein Coding	6.86	DISEASES inferred ¹⁵
18	GYPC	Glycophorin C (Gerbich Blood Group)	Protein Coding	6.83	DISEASES inferred ¹⁵
19	IFNL4	Interferon Lambda 4 (Gene/Pseudogene)	Protein Coding	6.6	GeneCards inferred via : Publications (show sections)
20	NXF1	Nuclear RNA Export Factor 1	Protein Coding	6.6	GeneCards inferred via : Publications (show sections)

Sources

Variations for Genital Herpes

Sources

Expression for Genital Herpes

Search GEO for disease gene expression data for Genital Herpes.

Sources

Pathways for Genital Herpes

Pathways related to Genital Herpes according to GeneCards Suite gene sharing:

(show all 31)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.96	TNFRSF14 TLR2 PI3 IL4 IL18 IL10
2	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.61	TNFRSF14 IL4 IL18 IL10 IFNE CD80
3	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.32	TNFRSF14 TLR2 IL4 IL18 IL10 CD80
4	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.29	TNFRSF14 IL4 IL18 IL10 CD80 CD4
5	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.2	TNFRSF14 NECTIN1 IL4 IL18 IL10 CD80
6	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.79	IL4 IL10 CD8A CD80 CD4
7	Herpes simplex virus 1 infection ³⁶	12.74	TNFRSF14 TLR2 NXF1 NECTIN1 CCL5
8	Immune response NFAT in immune response ²³ Show member pathways Immune response CD28 signaling ²³ Immune response ICOS pathway in T-helper cell ²³ Immune response T cell receptor signaling pathway ²³	12.57	IL4 IL18 IL10 CD80 CD4
9	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.54	TLR2 IL4 IL10 CD8A CD4
10	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease ³⁶ Th1 and Th2 cell differentiation ³⁶	12.51	TLR2 TBX21 IL4 IL18 IL10 CD4
11	NF-kappaB Signaling ⁴	12.38	TLR2 TBX21 IL4 IL10 IFI16 CD8A
12	Defensins ⁶⁵ Show member pathways Alpha-defensins ⁶⁵ Antimicrobial peptides ⁶⁵ Beta defensins ⁶⁵ Ion influx/efflux at host-pathogen interface ⁶⁵ Metal sequestration by antimicrobial proteins ⁶⁵	12.26	TLR2 PI3 CD4 CCR6
13	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.18	TNFRSF14 IL18 IL10 CCR6 CCL5 ACKR1
14	Cell adhesion molecules ³⁶	12.07	NECTIN1 CD8A CD80 CD4
15	Yersinia infection ³⁶	12.02	IL18 IL10 CD8A CD4
16	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.9	IL4 IL10 CD8A CD80 CD4
17	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²³	11.86	TBX21 IL4 IL18 CD8A CD4
18	Rheumatoid arthritis ³⁶	11.82	TLR2 IL18 CD80 CCL5
19	Th17 Differentiation Pathway ⁶⁴ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.8	TLR2 IL4 CD80 CD4
20	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.68	IL10 CD8A CD4
21	CTLA4 Signaling ⁶³	11.66	CD8A CD80 CD4
22	IgA-Producing B Cells in the Intestine ⁶⁴	11.63	TLR2 IL4 IL10 CCR6
23	Th2 Differentiation Pathway ⁶⁴	11.42	IL4 IL10 CD80 CD4
24	Malaria ³⁶	11.35	TLR2 IL18 IL10 GYPC ACKR1
25	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.31	TLR2 TBX21 IL18 IL10 CD80 CD4
26	Development and heterogeneity of the ILC family ¹	11.26	TBX21 IL4 IL18
27	Interleukin-10 signaling ⁶⁵	11.24	IL4 IL18 IL10 CD80 CCL5
28	Cytokines and Inflammatory Response ¹	11.21	IL4 IL10 CD4
29	IL12 signaling mediated by STAT4 ¹	11.18	TBX21 IL18 CD4
30	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.07	TBX21 IL4 IL18 IL10 CD8A CD4
31	G-protein signaling_Rap2B regulation pathway ²³	10.95	IL4 IL18 IL10 CD80 CCL5

Sources

GO Terms for Genital Herpes

Cellular components related to Genital Herpes according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.76	PI3 IL4 IL18 IL10 IFNL4 IFNE
2	extracellular region	GO:0005576	9.61	PI3 NECTIN1 IL4 IL18 IL10 IFNE
3	external side of plasma membrane	GO:0009897	9.02	TNFRSF14 CD8A CD80 CD4 CCR6

Biological processes related to Genital Herpes according to GeneCards Suite gene sharing:

(show all 23)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.95	TBX21 IL4 IL10 CD80 CD4 APOE
2	inflammatory response	GO:0006954	9.85	TLR2 IL18 IFI16 CCL5 ACKR1
3	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.79	TNFRSF14 CD80 CD4
4	viral entry into host cell	GO:0046718	9.78	TNFRSF14 NECTIN1 CD80
5	B cell differentiation	GO:0030183	9.73	IL4 IL10 IFNE
6	chemokine-mediated signaling pathway	GO:0070098	9.72	CCR6 CCL5 ACKR1
7	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.71	IL4 IL18 CCL5
8	neutrophil activation	GO:0042119	9.6	IL18 CCL5
9	positive regulation of granulocyte macrophage colony-stimulating factor production	GO:0032725	9.59	IL18 CD80
10	regulation of T cell activation	GO:0050863	9.58	CD4 CCL5
11	positive regulation of MHC class II biosynthetic process	GO:0045348	9.58	IL4 IL10
12	T cell activation	GO:0042110	9.58	IL4 CD8A CD4
13	response to molecule of bacterial origin	GO:0002237	9.57	TLR2 IL10
14	positive regulation of T cell proliferation	GO:0042102	9.56	IL4 CD80 CD4 CCL5
15	negative regulation of T-helper 17 cell differentiation	GO:2000320	9.52	TBX21 IL4
16	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.51	TBX21 IL4
17	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.5	TLR2 IL18 CCL5
18	cytokine-mediated signaling pathway	GO:0019221	9.5	IL4 IL18 IL10 IFNE CD80 CD4
19	positive regulation of amyloid-beta clearance	GO:1900223	9.49	IL4 APOE
20	lymphocyte migration	GO:0072676	9.43	TBX21 CCR6
21	regulation of isotype switching	GO:0045191	9.37	IL4 IL10
22	immune response	GO:0006955	9.36	TNFRSF14 TLR2 NECTIN1 IL4 IL18 IL10
23	type 2 immune response	GO:0042092	9.33	IL4 IL18 IL10

Molecular functions related to Genital Herpes according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor activity	GO:0038023	9.65	TLR2 NECTIN1 CD4 CCR6 ACKR1
2	virus receptor activity	GO:0001618	9.46	TNFRSF14 NECTIN1 CD80 CD4
3	coreceptor activity	GO:0015026	9.26	NECTIN1 CD8A CD80 CD4
4	cytokine activity	GO:0005125	9.1	IL4 IL18 IL10 IFNL4 IFNE CCL5

Sources

Sources for Genital Herpes

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Genital Herpes

Aliases & Classifications for Genital Herpes

MalaCards integrated aliases for Genital Herpes:

Classifications:

External Ids:

Summaries for Genital Herpes

Related Diseases for Genital Herpes

Diseases related to Genital Herpes via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Genital Herpes via Phenotypic Disease Network (PDN):

Graphical network of the top 20 diseases related to Genital Herpes:

Symptoms & Phenotypes for Genital Herpes

Symptoms:

UMLS symptoms related to Genital Herpes:

MGI Mouse Phenotypes related to Genital Herpes:

Drugs & Therapeutics for Genital Herpes

Drugs for Genital Herpes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 70 / NDF-RT 51 :

Cochrane evidence based reviews: herpes genitalis

Genetic Tests for Genital Herpes

Anatomical Context for Genital Herpes

The Foundational Model of Anatomy Ontology organs/tissues related to Genital Herpes:

MalaCards organs/tissues related to Genital Herpes:

Publications for Genital Herpes

Articles related to Genital Herpes:

Genes for Genital Herpes

Genes related to Genital Herpes (0 elite genes):

Variations for Genital Herpes

Expression for Genital Herpes

Pathways for Genital Herpes

Pathways related to Genital Herpes according to GeneCards Suite gene sharing:

GO Terms for Genital Herpes

Cellular components related to Genital Herpes according to GeneCards Suite gene sharing:

Biological processes related to Genital Herpes according to GeneCards Suite gene sharing:

Molecular functions related to Genital Herpes according to GeneCards Suite gene sharing:

Sources for Genital Herpes

Inferred drug relations via UMLS ⁷⁰ / NDF-RT ⁵¹ :