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MCID: GGR001
MIFTS: 52

Geographic Tongue

Categories: Gastrointestinal diseases, Oral diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Geographic Tongue

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MalaCards integrated aliases for Geographic Tongue:

Name: Geographic Tongue 12 76 53 15
Glossitis, Benign Migratory 44 73
Benign Migratory Glossitis 12 53
Glossitis Areata Exfoliativa 12
Erythema Chronicum Migrans 73
Ectopic Geographic Tongue 53
Pityriasis Linguae 12
Erythema Migrans 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1455
ICD10 33 K14.1
ICD9CM 35 529.1
MeSH 44 D005929
NCIt 50 C84588
SNOMED-CT 68 59032001
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Summaries for Geographic Tongue

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NIH Rare Diseases : 53 Geographic tongue is a condition that causes chronic and recurrent lesions on the tongue that resemble psoriasis of the skin. It is characterized by pink to red, slightly depressed lesions with irregular, elevated, white or yellow borders. The lesions may also occur in the mucosa of the mouth and labia; this condition is called "areata migrans" because these lesions typically disappear from one area and show up in another. The tongue is normally covered with tiny, pinkish-white bumps (papillae), which are actually short, fine, hair-like projections. With geographic tongue, patches on the surface of the tongue are missing papillae and appear as smooth, red "islands," often with slightly raised borders. These patches (lesions) give the tongue a map-like, or geographic, appearance. In most cases there are no symptoms but sometimes it is painful when inflamed. The cause of this condition is unknown. Many researchers think it is linked with psoriasis, but more research is needed to better understand the connection. Also, hereditary and environmental factors may be involved. The condition is benign and localized, generally requiring no treatment except reassurance. If painful, it may be treated with steroid gels or antihistamine mouth rinses. 

MalaCards based summary : Geographic Tongue, also known as glossitis, benign migratory, is related to pustular psoriasis and pustulosis of palm and sole, and has symptoms including exanthema, erythema of the eyelids and glossalgia. An important gene associated with Geographic Tongue is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Doxycycline and Cefuroxime have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and whole blood, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 An atrophic glossitis that is characterized as an inflammatory condition of the mucous membrane of the tongue, usually on the dorsal surface.

Wikipedia : 76 Geographic tongue, also known by several other terms,[note 1] is an inflammatory condition of the mucous... more...

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Related Diseases for Geographic Tongue

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Diseases related to Geographic Tongue via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 pustular psoriasis 30.1 IL36RN TNF
2 pustulosis of palm and sole 29.7 IL36RN TNF
3 celiac disease 1 29.6 HLA-A HLA-DQB1 HLA-DQB2 TNF
4 lyme disease 11.8
5 fissured tongue 11.7
6 acrodermatitis chronica atrophicans 10.4
7 psoriasis 10.3
8 limbic encephalitis with lgi1 antibodies 10.3 HLA-DQB1 HLA-DRB1
9 narcolepsy 2 10.3 HLA-DQB1 HLA-DRB1
10 phenytoin or carbamazepine toxicity 10.3 HLA-A HLA-B
11 autoimmune polyglandular syndrome type 3 10.3 HLA-DQB1 HLA-DRB1
12 recurrent hypersomnia 10.3 HLA-DQB1 HLA-DQB2
13 hypersomnia 10.2 HLA-DQB1 HLA-DRB1
14 atrial tachyarrhythmia with short pr interval 10.2 HLA-A HLA-B
15 metal allergy 10.2 HLA-DQB1 HLA-DRB1
16 lichen planopilaris 10.2 HLA-DQB1 HLA-DRB1
17 type ii mixed cryoglobulinemia 10.2 HLA-DQB1 HLA-DRB1
18 glossitis 10.2
19 narcolepsy 1 10.2 HLA-DQB1 HLA-DRB1
20 idiopathic inflammatory myopathy 10.2 HLA-B HLA-DRB1
21 maturity-onset diabetes of the young, type 14 10.2 HLA-DQB1 HLA-DQB2
22 autoimmune hepatitis 10.2 HLA-A HLA-DQB1 HLA-DRB1
23 postherpetic neuralgia 10.2 HLA-A HLA-B HLA-DRB1
24 pars planitis 10.2 HLA-A HLA-B HLA-DRB1
25 histoplasmosis 10.2 HLA-A HLA-B HLA-DRB1
26 pure red-cell aplasia 10.2 HLA-A HLA-B HLA-DRB1
27 atrophic glossitis 10.1 HLA-A HLA-DQB2 IL36RN WHRN
28 human herpesvirus 8 10.1 HLA-A HLA-B HLA-C
29 acute disseminated encephalomyelitis 10.1 HLA-B HLA-DQB1 HLA-DRB1
30 recurrent respiratory papillomatosis 10.1 EGFR HLA-DQB1 HLA-DRB1
31 lichen planus 10.1
32 paronychia 10.1 EGFR MTOR
33 drug reaction with eosinophilia and systemic symptoms 10.1 HLA-B TNF
34 vogt-koyanagi-harada disease 10.1 HLA-A HLA-B HLA-DQB1 HLA-DRB1
35 melanoma, uveal 10.1 HLA-A HLA-B NME1
36 beryllium disease 10.0 HLA-DQB1 HLA-DRB1 TNF
37 dengue shock syndrome 10.0 HLA-A HLA-DRB1 TNF
38 chronic beryllium disease 10.0 HLA-DQB1 HLA-DRB1 TNF
39 microscopic colitis 10.0 HLA-DQB1 HLA-DRB1 TNF
40 stevens-johnson syndrome/toxic epidermal necrolysis 10.0 EPHX1 HLA-A HLA-B HLA-C
41 oligoarticular juvenile idiopathic arthritis 10.0 HLA-DQB1 HLA-DRB1 TNF
42 anterior uveitis 10.0 HLA-A HLA-B TNF
43 salpingitis 10.0 AKTIP TNF
44 echinococcosis 10.0 HLA-B HLA-DRB1 TNF
45 aphthous stomatitis 10.0 HLA-A HLA-B TNF
46 sympathetic ophthalmia 10.0 HLA-C HLA-DRB1 TNF
47 cholangitis 10.0 HLA-B HLA-DRB1 TNF
48 microscopic polyangiitis 10.0 HLA-B HLA-DRB1 TNF
49 median rhomboid glossitis 10.0
50 dermatitis 10.0

Graphical network of the top 20 diseases related to Geographic Tongue:



Diseases related to Geographic Tongue
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Symptoms & Phenotypes for Geographic Tongue

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UMLS symptoms related to Geographic Tongue:


exanthema, erythema of the eyelids, glossalgia, heliotrope rash

GenomeRNAi Phenotypes related to Geographic Tongue according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.35 HLA-A HLA-B HLA-C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.35 HLA-A HLA-B HLA-C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.35 HLA-A HLA-B HLA-C EGFR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.35 EGFR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.35 HLA-C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.35 HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.35 HLA-A HLA-B HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.35 HLA-C
9 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.35 HLA-A HLA-B HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.35 HLA-A HLA-B HLA-C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.35 EGFR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.35 HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.35 EGFR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.35 EGFR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.35 HLA-A HLA-B HLA-C
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.35 EGFR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.35 HLA-C
18 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.35 HLA-A HLA-B HLA-C
19 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.35 HLA-A HLA-B HLA-C
20 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.35 EGFR
21 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.35 HLA-C
22 Decreased viability with paclitaxel GR00179-A-1 9.35 EGFR MTOR
23 Decreased viability with paclitaxel GR00179-A-2 9.35 MTOR
24 Decreased viability with paclitaxel GR00179-A-3 9.35 EGFR MTOR

MGI Mouse Phenotypes related to Geographic Tongue:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.17 EGFR HLA-DQB1 NME1 THEM5 TNF VEGFA
Sources

Drugs & Therapeutics for Geographic Tongue

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Drugs for Geographic Tongue (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Not Applicable 564-25-0 54671203
2
Cefuroxime Approved Phase 4,Not Applicable 55268-75-2 5361202 5479529
3
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
4
Amoxicillin Approved, Vet_approved Phase 4,Not Applicable 26787-78-0 33613
5 Anti-Infective Agents Phase 4,Phase 1,Phase 2,Not Applicable
6 Antiparasitic Agents Phase 4,Not Applicable
7 Antiprotozoal Agents Phase 4,Not Applicable
8 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2,Not Applicable
9 Antimalarials Phase 4,Not Applicable
10 cefuroxime axetil Phase 4,Not Applicable
11 penicillins Phase 4
12 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2,Not Applicable
13
Ceftriaxone Approved Not Applicable 73384-59-5 5479530 5361919
14 Antibodies
15 Immunoglobulins
16 Antitubercular Agents Not Applicable
17 Immunoglobulin A
18 Immunoglobulin G
19 Immunoglobulin M

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed NCT01518192 Phase 4 doxycycline;cefuroxime axetil
2 Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice Completed NCT01368341 Phase 4 Doxycycline;Phenoxymethylpenicillin;Amoxicillin
3 Xenodiagnosis After Antibiotic Treatment for Lyme Disease Recruiting NCT02446626 Phase 1, Phase 2 Xenodiagnosis
4 The Relationship Between Allergic Rhinitis and Geographic Tongue Unknown status NCT01454492
5 Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis Unknown status NCT00942006 Not Applicable doxycycline;ceftriaxone
6 Duration of Antibiotic Treatment of Erythema Migrans Completed NCT00910715 Not Applicable doxycycline;doxycycline;placebo
7 Comparison of Doxycycline and Cefuroxime Axetil in Erythema Migrans Completed NCT03584919 Not Applicable doxycycline;Cefuroxime Axetil 500Mg Tab
8 Doxycycline in Therapy of Erythema Migrans Completed NCT01475708 Doxycycline
9 Culture Media for Borrelia Burgdorferi Sensu Lato Completed NCT02145754 Not Applicable
10 Analysis of Lyme Disease Lesions Completed NCT00132327
11 Searching for Persistence of Infection in Lyme Disease Completed NCT01143558 Early Phase 1
12 Sofia 2 Lyme FIA Whole Blood Clinical Study Completed NCT03238274
13 Cytokines and Chemokines in Erythema Migrans Recruiting NCT02147249 Not Applicable antibiotic treatment
14 Antibiotic Treatment of Multiple Erythema Migrans Recruiting NCT01163994 Not Applicable ceftriaxone;doxycycline
15 Duration of Doxycycline Treatment in EM Patients Recruiting NCT03153267 Not Applicable Doxycycline 100 MG Oral Tablet bid, 7 days;Doxycycline 100 MG Oral Tablet bid, 14 days;Controls without a history of lyme disease.
16 Patient's Pretreatment Expectations About Post-Lyme Symptoms Recruiting NCT03462329 Not Applicable Antibiotics (preferentially oral doxycycline 100 mg bid)
17 Duration of Doxycycline Treatment in MEM Patients Recruiting NCT03337932 Not Applicable Doxycycline 100 milligram Oral Tablet bid, 7 days;Doxycycline 100 milligram Oral Tablet bid, 14 days;Controls without a history of lyme disease.
18 Next Generation Sequencing Detection of Lyme Disease Recruiting NCT03505879
19 Lyme Borreliosis and Early Cutaneous Diagnostic Recruiting NCT02414789 Not Applicable
20 Understanding Tick-borne Diseases Recruiting NCT03501407
21 Detection of Borrelia Bacteria in Early Stage Lyme Borreliosis Using the T2Lyme Panel Recruiting NCT03581279 Not Applicable
22 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082
23 Erythema Migrans in Elderly Active, not recruiting NCT03371563 Antibiotics
24 Investigation of Southern Tick-Associated Rash Illness (STARI) Terminated NCT00358761
25 A Multicenter Study to Evaluate a Borrelia Diagnostic Test in Subjects With Early Stage or Late Stage Lyme Disease Terminated NCT02741609 Not Applicable
26 Lyme Test Indication Combinations (LyTIC) Study Terminated NCT03201042

Search NIH Clinical Center for Geographic Tongue

Cochrane evidence based reviews: glossitis, benign migratory

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Genetic Tests for Geographic Tongue

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Anatomical Context for Geographic Tongue

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MalaCards organs/tissues related to Geographic Tongue:

41
Tongue, Skin, Whole Blood, Lung, Kidney, Heart
Sources

Publications for Geographic Tongue

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Articles related to Geographic Tongue:

(show top 50) (show all 99)
# Title Authors Year
1
An infant with generalized pustular psoriasis and geographic tongue had a heterozygous IL36RN mutation and IgG2 deficiency. ( 29454537 )
2018
2
Acrodermatitis continua of Hallopeau and geographic tongue are variants of pustular psoriasis. ( 29687071 )
2018
3
Geographic tongue: Predisposing factors, diagnosis and treatment. A systematic review. ( 29903400 )
2018
4
Geographic tongue induced by angiogenesis inhibitors. ( 30336939 )
2018
5
Geographic tongue that responds to the treatment of pregabalin: Can it be a new treatment choice? ( 30365234 )
2018
6
Effectiveness of the Tacrolimus Swish-and-Spit Treatment Regimen in Patients With Geographic Tongue. ( 30419108 )
2018
7
Geographic tongue: assessment of peripheral nerve status, Langerhans cell, and HLA-DR expression. ( 28757081 )
2017
8
Geographic Tongue. ( 28716459 )
2017
9
Investigation of the clinical features of geographic tongue: unveiling its relationship with oral psoriasis. ( 28188609 )
2017
10
Salivary levels of interleukin-8 and growth factors are modulated in patients with geographic tongue. ( 28178402 )
2017
11
Lingual microbiota profiles of patients with geographic tongue. ( 28839519 )
2017
12
IMAGES IN CLINICAL MEDICINE. Geographic Tongue. ( 26886524 )
2016
13
Geographic tongue and psoriasis: clinical, histopathological, immunohistochemical and genetic correlation - a literature review. ( 27579734 )
2016
14
Oral medicine: Factors associated with geographic tongue and fissured tongue. ( 27388082 )
2016
15
The prevalence of celiac disease in patients with geographic tongue. ( 27131886 )
2016
16
Geographic Tongue. ( 27436616 )
2016
17
Paediatric Geographic Tongue: A Case Report, Review and Recent Updates. ( 27042597 )
2016
18
Geographic tongue associated with sialadenitis. ( 27726175 )
2016
19
Geographic tongue. ( 27505875 )
2016
20
Treatment of Symptomatic Geographic Tongue with Triamcinolone Acetonide Alone and in Combination with Retinoic Acid: A Randomized Clinical Trial. ( 27536325 )
2016
21
Mutations in IL36RN are associated with geographic tongue. ( 27900482 )
2016
22
Factors associated with geographic tongue and fissured tongue. ( 26381370 )
2015
23
Prevalence of Geographic tongue and Related Predisposing Factors in 7-18 Year-Old Students in Kermanshah, Iran 2014. ( 26156909 )
2015
24
Geographic tongue and fissured tongue in 348 patients with psoriasis: correlation with disease severity. ( 25685842 )
2015
25
Psychological parameters associated with geographic tongue: a clinical observation. ( 25482552 )
2015
26
Psychological parameters associated with geographic tongue: a clinical observation. ( 25482551 )
2015
27
A possible relationship of human leucocyte antigens with psoriasis vulgaris and geographic tongue. ( 25176018 )
2014
28
Medical image. A benign glossal lesion. Geographic tongue. ( 24929575 )
2014
29
Relation between psoriasis and geographic tongue. ( 25584342 )
2014
30
Treatment of geographic tongue with topical tacrolimus. ( 25085945 )
2014
31
Immunologic and psychologic parameters associated with geographic tongue. ( 24842481 )
2014
32
Case of the month. Ectopic geographic tongue (erythema migrans). ( 24937889 )
2014
33
Geographic tongue in monozygotic twins. ( 24959517 )
2014
34
Geographic tongue induced by angiogenesis inhibitors. ( 23576484 )
2013
35
Geographic tongue and tenofovir. ( 23598934 )
2013
36
Geographic Tongue and Associated Risk Factors among Iranian Dental Patients. ( 23515238 )
2013
37
Oral and maxillofacial pathology case of the month. Erythema migrans (ectopic migratory glossitis/ectopic geographic tongue). ( 24236384 )
2013
38
The comparison of salivary level of estrogen and progesterone in 1(st) , 2(nd) and 3(rd) trimester in pregnant women with and without geographic tongue. ( 24348617 )
2013
39
Increased prevalence of geographic tongue in burning mouth complaints: a retrospective study. ( 22901641 )
2012
40
Migratory stomatitis (ectopic geographic tongue) on the floor of the mouth. ( 21763590 )
2011
41
Geographic tongue treated with topical tacrolimus. ( 21886753 )
2010
42
Images in clinical medicine. Geographic tongue. ( 19907039 )
2009
43
Oral medicine case book 7. Migratory stomatitis and geographic tongue. ( 18689340 )
2008
44
Ectopic geographic tongue--a case report. ( 17432777 )
2007
45
Prevalence and risk factors associated with geographic tongue among US adults. ( 16792723 )
2006
46
Geographic tongue: clinical characteristics of 188 cases. ( 15719084 )
2005
47
Geographic tongue: literature review and case reports. ( 16161818 )
2005
48
Geographic tongue in two children with nonpustular psoriasis. ( 15660908 )
2005
49
Painful geographic tongue (benign migratory glossitis) in a child. ( 15482313 )
2004
50
Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. ( 15316160 )
2004
Sources

Variations for Geographic Tongue

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Expression for Geographic Tongue

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Search GEO for disease gene expression data for Geographic Tongue.
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Pathways for Geographic Tongue

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Pathways related to Geographic Tongue according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.93 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2
2
Class I MHC mediated antigen processing and presentation 66
Show member pathways
 13.32 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.13 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2
4
Human cytomegalovirus infection 37
Show member pathways
 12.91 EGFR HLA-A HLA-B HLA-C MTOR TNF
5
Actin Nucleation by ARP-WASP Complex 64
Show member pathways
 12.89 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
6
PI3K-Akt signaling pathway 37
Show member pathways
 12.84 EGFR HLA-A HLA-B HLA-C MTOR TNF
7
Th17 cell differentiation 37
Show member pathways
 12.49 HLA-DQB1 HLA-DQB2 HLA-DRB1 MTOR TNF
8
Influenza A 37
Show member pathways
 12.49 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 TNF
9
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.4 HLA-A HLA-B HLA-C TNF TNFRSF10B
10
Interferon gamma signaling 66
Show member pathways
 12.37 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
11
Endocytosis 37
12.31 EGFR HLA-A HLA-B HLA-C
12
Proteoglycans in cancer 37
12.22 EGFR MTOR TNF VEGFA
13
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.16 EGFR HLA-A HLA-B HLA-C TNF
14
CD28 co-stimulation 66
Show member pathways
 12.14 HLA-DQB1 HLA-DQB2 HLA-DRB1 MTOR
15
Cellular senescence (KEGG) 37
12.08 HLA-A HLA-B HLA-C MTOR
16
Human T-cell leukemia virus 1 infection 37
12.04 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 TNF
17
Phagosome 37
12.01 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
18
Allograft rejection 1 37
Show member pathways
 11.96 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
19
IL12-mediated signaling events 1
Show member pathways
 11.88 HLA-A HLA-DRB1 MTOR
20
Cell adhesion molecules (CAMs) 37
11.88 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
21
G-protein signaling N-RAS regulation pathway 22
Show member pathways
 11.87 EGFR HLA-DQB1 HLA-DQB2 HLA-DRB1
22
Translocation of ZAP-70 to Immunological synapse 66
Show member pathways
 11.86 HLA-DQB1 HLA-DQB2 HLA-DRB1
23
S-1P Stimulated Signaling 64
11.85 EGFR HLA-DQB1 HLA-DQB2 HLA-DRB1
24
MHC class II antigen presentation 66
11.82 HLA-DQB1 HLA-DQB2 HLA-DRB1
25
HIF-1 signaling pathway 37
11.8 EGFR MTOR VEGFA
26
Hematopoietic cell lineage 37
11.79 HLA-DQB1 HLA-DRB1 TNF
27
Rheumatoid arthritis 37
11.75 HLA-DQB1 HLA-DRB1 TNF VEGFA
28
Epstein-Barr virus infection 37
11.74 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 TNF
29
Aryl Hydrocarbon Receptor 1
11.45 EGFR TNF VEGFA
30
Antigen Presentation- Folding, assembly and peptide loading of class I MHC 66
11.08 HLA-A HLA-B HLA-C
Sources

GO Terms for Geographic Tongue

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Cellular components related to Geographic Tongue according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 lysosomal membrane GO:0005765 9.88 HLA-DQB1 HLA-DQB2 HLA-DRB1 MTOR
2 cell surface GO:0009986 9.86 EGFR HLA-A HLA-B HLA-C HLA-DRB1 TNF
3 endosome membrane GO:0010008 9.83 EGFR HLA-DQB1 HLA-DQB2 HLA-DRB1
4 early endosome membrane GO:0031901 9.76 EGFR HLA-A HLA-B HLA-C
5 Golgi membrane GO:0000139 9.76 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2
6 trans-Golgi network membrane GO:0032588 9.75 HLA-DQB1 HLA-DQB2 HLA-DRB1
7 recycling endosome membrane GO:0055038 9.72 HLA-A HLA-B HLA-C
8 phagocytic vesicle membrane GO:0030670 9.71 HLA-A HLA-B HLA-C
9 endocytic vesicle membrane GO:0030666 9.69 HLA-DQB1 HLA-DQB2 HLA-DRB1
10 transport vesicle membrane GO:0030658 9.65 HLA-DQB1 HLA-DQB2 HLA-DRB1
11 clathrin-coated endocytic vesicle membrane GO:0030669 9.61 HLA-DQB1 HLA-DQB2 HLA-DRB1
12 MHC class II protein complex GO:0042613 9.54 HLA-DQB1 HLA-DQB2 HLA-DRB1
13 MHC class I protein complex GO:0042612 9.5 HLA-A HLA-B HLA-C
14 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
15 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.1 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
16 membrane GO:0016020 10.4 AKTIP EGFR EPHX1 HLA-A HLA-B HLA-C
17 plasma membrane GO:0005886 10.33 AKTIP EGFR HLA-A HLA-B HLA-C HLA-DQB1
18 endoplasmic reticulum membrane GO:0005789 10.04 EGFR EPHX1 HLA-A HLA-DQB2 HLA-DRB1 MTOR
19 Golgi apparatus GO:0005794 10.04 EGFR HLA-A HLA-B HLA-C HLA-DQB2 HLA-DRB1
20 endoplasmic reticulum GO:0005783 10.01 EGFR EPHX1 HLA-A HLA-B HLA-C HLA-DQB2

Biological processes related to Geographic Tongue according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.97 HLA-A HLA-B HLA-C HLA-DQB2 HLA-DRB1 IL36RN
2 T cell receptor signaling pathway GO:0050852 9.8 HLA-DQB1 HLA-DQB2 HLA-DRB1
3 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.78 HLA-DQB1 HLA-DQB2 HLA-DRB1
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.77 EGFR TNF VEGFA
5 positive regulation of protein phosphorylation GO:0001934 9.77 AKTIP EGFR MTOR TNF VEGFA
6 type I interferon signaling pathway GO:0060337 9.76 HLA-A HLA-B HLA-C
7 immune response GO:0006955 9.76 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
8 positive regulation of epithelial cell proliferation GO:0050679 9.75 EGFR NME1 VEGFA
9 positive regulation of MAP kinase activity GO:0043406 9.74 EGFR TNF VEGFA
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.73 EGFR MTOR TNF
11 cellular response to amino acid stimulus GO:0071230 9.72 EGFR MTOR TNF
12 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.65 HLA-A HLA-B HLA-C
13 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.63 HLA-A HLA-B HLA-C
14 positive regulation of glial cell proliferation GO:0060252 9.62 MTOR TNF
15 regulation of osteoclast differentiation GO:0045670 9.61 MTOR TNF
16 positive regulation of T cell mediated cytotoxicity GO:0001916 9.61 HLA-A HLA-B HLA-C
17 astrocyte activation GO:0048143 9.59 EGFR TNF
18 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.58 HLA-DQB1 HLA-DQB2 HLA-DRB1
19 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.54 HLA-DQB1 HLA-DRB1
20 protection from natural killer cell mediated cytotoxicity GO:0042270 9.52 HLA-A HLA-B
21 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.51 HLA-DQB1 HLA-DRB1
22 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.5 HLA-A HLA-B HLA-C
23 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.43 HLA-A HLA-B HLA-C
24 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
25 antigen processing and presentation GO:0019882 9.1 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1

Molecular functions related to Geographic Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.13 HLA-DQB1 HLA-DQB2 HLA-DRB1
2 peptide antigen binding GO:0042605 9.02 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
Sources

Sources for Geographic Tongue

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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