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MCID: GGR001
MIFTS: 38

Geographic Tongue

Categories: Gastrointestinal diseases, Oral diseases, Rare diseases, Smell/Taste diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Geographic Tongue

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MalaCards integrated aliases for Geographic Tongue:

Name: Geographic Tongue 12 73 20 15 17 32
Glossitis, Benign Migratory 44 70
Benign Migratory Glossitis 12 20
Glossitis Areata Exfoliativa 12
Erythema Chronicum Migrans 70
Ectopic Geographic Tongue 20
Pityriasis Linguae 12
Erythema Migrans 20

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Oral diseases Smell/Taste diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1455
ICD9CM 34 529.1
MeSH 44 D005929
NCIt 50 C84588
SNOMED-CT 67 59032001
ICD10 32 K14.1
UMLS 70 C0014740 C0017677
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Summaries for Geographic Tongue

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GARD : 20 Geographic tongue is a condition that causes chronic and recurrent lesions on the tongue that resemble psoriasis of the skin. It is characterized by pink to red, slightly depressed lesions with irregular, elevated, white or yellow borders. The lesions may also occur in the mucosa of the mouth and labia; this condition is called "areata migrans" because these lesions typically disappear from one area and show up in another. The tongue is normally covered with tiny, pinkish-white bumps ( papillae ), which are actually short, fine, hair-like projections. With geographic tongue, patches on the surface of the tongue are missing papillae and appear as smooth, red "islands," often with slightly raised borders. These patches (lesions) give the tongue a map-like, or geographic, appearance. In most cases there are no symptoms but sometimes it is painful when inflamed. The cause of this condition is unknown. Many researchers think it is linked with psoriasis, but more research is needed to better understand the connection. Also, hereditary and environmental factors may be involved. The condition is benign and localized, generally requiring no treatment except reassurance. If painful, it may be treated with steroid gels or antihistamine mouth rinses.

MalaCards based summary : Geographic Tongue, also known as glossitis, benign migratory, is related to pustulosis of palm and sole and psoriasis 14, pustular, and has symptoms including exanthema, erythema of the eyelids and glossalgia. An important gene associated with Geographic Tongue is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Phagosome and Intraflagellar transport. The drugs Cefuroxime and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include tongue, whole blood and skin.

Disease Ontology : 12 An atrophic glossitis that is characterized as an inflammatory condition of the mucous membrane of the tongue, usually on the dorsal surface.

Wikipedia : 73 Geographic tongue, also known by several other terms,[note 1] is a condition of the mucous membrane of... more...

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Related Diseases for Geographic Tongue

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Diseases related to Geographic Tongue via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 pustulosis of palm and sole 30.6 LPIN2 IL36RN IL1RL2
2 psoriasis 14, pustular 30.3 IL36RN IL1RL2
3 lyme disease 11.6
4 fissured tongue 11.3
5 glossitis 10.5
6 acrodermatitis chronica atrophicans 10.5
7 psoriasis 10.5
8 cellulitis 10.3
9 median rhomboid glossitis 10.3
10 atrioventricular block 10.2
11 localized scleroderma 10.2
12 dermatophytosis 10.2
13 impetigo herpetiformis 10.2 IL36RN IL1RL2
14 pustular psoriasis 10.2
15 annular erythema 10.2
16 tick-borne encephalitis 10.2
17 facial paralysis 10.2
18 cytokine deficiency 10.2
19 ige responsiveness, atopic 10.1
20 hairy tongue 10.1
21 dermatitis 10.1
22 htlv-1 associated myelopathy/tropical spastic paraparesis 10.1 HLA-DQB1 HLA-A
23 pityriasis rosea 10.1 HLA-DQB1 HLA-A
24 short-rib thoracic dysplasia 8 with or without polydactyly 10.1 DYNLT2B DYNC2H1
25 alveolar echinococcosis 10.1 HLA-DQB1 HLA-A
26 miliaria pustulosa 10.1 LPIN2 IL1RL2
27 short-rib thoracic dysplasia 11 with or without polydactyly 10.1 DYNLT2B DYNC2H1
28 paraneoplastic pemphigus 10.1 HLA-DQB1 HLA-A
29 cytomegalovirus retinitis 10.1 HLA-DQB1 HLA-A
30 autoimmune disease 10.1
31 anxiety 10.1
32 secondary syphilis 10.1
33 syphilis 10.1
34 pure red-cell aplasia 10.1 HLA-DQB1 HLA-A
35 disease by infectious agent 10.1
36 spotted fever 10.1
37 erysipelas 10.1
38 aseptic meningitis 10.1
39 tinea corporis 10.1
40 neutropenia 10.1
41 urticaria 10.1
42 thrombocytopenia 10.1
43 myelitis 10.1
44 systemic scleroderma 10.1
45 myocarditis 10.1
46 herpes zoster 10.1
47 encephalitis 10.1
48 alopecia 10.1
49 47,xyy 10.1
50 burning mouth syndrome 10.1

Graphical network of the top 20 diseases related to Geographic Tongue:



Diseases related to Geographic Tongue
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Symptoms & Phenotypes for Geographic Tongue

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UMLS symptoms related to Geographic Tongue:


exanthema; erythema of the eyelids; glossalgia; heliotrope rash
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Drugs & Therapeutics for Geographic Tongue

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Drugs for Geographic Tongue (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
3
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
4 cefuroxime axetil Phase 4
5 penicillins Phase 4
6
Ceftriaxone Approved 73384-59-5 5479530 5361919
7
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
8 Antibodies
9 Immunoglobulins
10 Antibiotics, Antitubercular
11 Anti-Bacterial Agents
12 Antimalarials
13 Antiparasitic Agents
14 Anti-Infective Agents
15 Antiprotozoal Agents

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Risk Factors for Failure of Erythema Migrans Treatment - Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Adult Patients With Erythema Migrans: Clinical and Microbiological Outcome. Completed NCT01518192 Phase 4 doxycycline;cefuroxime axetil
2 Tick Borne Diseases in Norwegian General Practice. A Randomized, Controlled Trial for Treatment of Erythema Migrans in Norwegian General Practice. A Comparison of Phenoxymethylpenicillin, Amoxicillin and Doxycycline. Completed NCT01368341 Phase 4 Doxycycline;Phenoxymethylpenicillin;Amoxicillin
3 Comparison of Ceftriaxone and Doxycycline for Treatment of Multiple Erythema Migrans Unknown status NCT01163994 ceftriaxone;doxycycline
4 Inflammatory Proteins, Gene Polymorphisms, and Transcriptome Profiles in Patients With Erythema Migrans Unknown status NCT02147249 antibiotic treatment
5 Doxycycline and Ceftriaxone in Patients With Suspected Early Lyme Neuroborreliosis and Normal CSF Cell Count. Unknown status NCT00942006 doxycycline;ceftriaxone
6 The Relationship Between Allergic Rhinitis and Geographic Tongue Unknown status NCT01454492
7 One-Health Approach to Identify Threat Posed by Tick-borne Pathogens Responsible of Unexplained Infectious Syndrome in Humans Unknown status NCT03501407
8 Duration of Antibiotic Treatment of Erythema Migrans. A Randomized Clinical Trial. Completed NCT00910715 doxycycline;doxycycline;placebo
9 Comparison of Two Culture Media for Cultivation of Borrelia Burgdorferi Sensu Lato Completed NCT02145754
10 Comparison of Doxycycline and Cefuroxime Axetil in Patients With Erythema Migrans Completed NCT03584919 doxycycline;Cefuroxime Axetil 500Mg Tab
11 Doxycycline in Therapy of Erythema Migrans - do the Accompanying Symptoms Influence the Outcome? Completed NCT01475708 Doxycycline
12 Inflammatory Proteins, Gene Polymorphisms, and Transcriptome Profiles in Patients With Erythema Migrans Completed NCT03956212 Doxycycline 7 days;Doxycycline 14 days
13 Analysis of Erythema Migrans Lesions Completed NCT00132327
14 Inflammatory Responses in Borrelia Afzelii Culture Positive Patients With Early Disseminated or Early Localized Lyme Borreliosis Completed NCT03980015
15 Clinical Course, Serologic Response and Long-term Outcome in Elderly Patients With Early Lyme Borreliosis Completed NCT03371563 Antibiotics
16 Duration of Doxycycline Treatment in Patients With Erythema Migrans (EM). A Randomized Clinical Trial. Completed NCT03153267 Doxycycline 100 MG Oral Tablet bid, 7 days;Doxycycline 100 MG Oral Tablet bid, 14 days;Controls without a history of lyme disease.
17 Sofia 2 Lyme FIA Whole Blood Clinical Study Completed NCT03238274
18 Lyme Borreliosis and Early Cutaneous Diagnostic Recruiting NCT02414789
19 Different Duration and Dosing of Amoxicillin in Patients With Erythema Migrans. A Randomized Clinical Trial. Recruiting NCT03966014 EM-amoxicillin 3 x 10 days;EM-amoxicillin 3 x 14 days;EM-amoxicillin 2 x 14 days
20 Impact of Patient's Pretreatment Expectations on Treatment Outcome of Early Lyme Borreliosis Recruiting NCT03462329 Antibiotics (preferentially oral doxycycline 100 mg bid)
21 Next Generation Sequencing to Detect Borrelia Burgdorferi DNA in the Blood of Pediatric Patients With Lyme Disease Recruiting NCT03505879
22 Duration of Doxycycline Treatment in Patients With Multiple Erythema Migrans (MEM). A Randomized Clinical Trial Recruiting NCT03337932 Doxycycline 100 milligram Oral Tablet bid, 7 days;Doxycycline 100 milligram Oral Tablet bid, 14 days;Controls without a history of lyme disease.

Search NIH Clinical Center for Geographic Tongue

Cochrane evidence based reviews: glossitis, benign migratory

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Genetic Tests for Geographic Tongue

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Anatomical Context for Geographic Tongue

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MalaCards organs/tissues related to Geographic Tongue:

40
Tongue, Whole Blood, Skin
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Publications for Geographic Tongue

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Articles related to Geographic Tongue:

(show top 50) (show all 285)
# Title Authors PMID Year
1
Non-specific oral and cutaneous manifestations of Coronavirus Disease 2019 in children. 61
33772567 2021
2
Geographic tongue as a reaction-diffusion system. 61
33810753 2021
3
Scrotal erythema and geographic tongue subsequent to multikinase inhibiting therapy with Pazopanib. 61
33277963 2021
4
A novel evaluation method for Ki-67 immunostaining in paraffin-embedded tissues. 61
33464376 2021
5
Prevalence of oral mucosal normal variations and lesions in a middle-aged population: a Northern Finland Birth Cohort 1966 study. 61
33298037 2020
6
Impact of oral lesions on the quality of life of psoriatic individuals: A case-control study. 61
33107194 2020
7
Differences in the Incidence of Pathologic Lesions on the Oral Mucosa in Patients Undergoing Hemodialysis vs Renal Organ Transplant Recipients Subjected to Long-term Pharmacologic Immunosuppressive Therapy. 61
32222390 2020
8
Oral rehabilitation in a patient with Jeune syndrome presenting with multiple teeth agenesis. 61
32620036 2020
9
Oral mucosal lesions in psoriatic patients based on disease severity and treatment approach. 61
33245622 2020
10
Oral mucosal lesions in a COVID-19 patient: New signs or secondary manifestations? 61
32526392 2020
11
Taste and Pain Response in Burning Mouth Syndrome With and Without Geographic Tongue. 61
32870950 2020
12
Investigation of oral atopic diseases: Correlation between geographic tongue and fungiform papillary glossitis. 61
32540362 2020
13
The use of Velscope to assess cellular changes occuring in oral premalignancy. 61
32211285 2020
14
Geographic tongue severity index: A new and clinical scoring system. 61
31974034 2020
15
Photobiomodulation Effect of Low-level Laser Therapy as a Palliative Treatment of Symptomatic Geographic Tongue (A Double-blinded Randomized Clinical Trial). 61
32584285 2020
16
Increased levels of calprotectin in the saliva of patients with geographic tongue. 61
31845422 2020
17
Assessment of salivary antioxidant status and immunoglobulin E in patients with geographic tongue. 61
32110568 2020
18
Clinical Orodental Anomalies in Taiwanese Children under Age Six: a Study Based on the 1995-1997 National Dental Survey. 61
32766305 2020
19
Feeding problems and gastrointestinal diseases in Down syndrome. 61
31784293 2020
20
Photobiomodulation in Oral Medicine. 61
31873066 2019
21
Evaluation of the Th17 pathway in psoriasis and geographic tongue. 61
31789253 2019
22
Geographic stomatitis: An enigmatic condition with multiple clinical presentations. 61
31636878 2019
23
Red patches on the tongue with white borders • history of geographic tongue • incompletely treated celiac disease • Dx? 61
31532821 2019
24
Geographic stomatitis with palate involvement. 61
33272509 2019
25
World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review. 61
31034120 2019
26
Association of geographic tongue and fissured tongue with ABO blood group among adult psoriasis patients: a novel study from a tertiary care hospital in Saudi Arabia. 61
30902460 2019
27
Genetic and developmental disorders of the oral mucosa: Epidemiology; molecular mechanisms; diagnostic criteria; management. 61
31090139 2019
28
Geographic Tongue: What a Dermatologist Should Know. 61
31005233 2019
29
GEOGRAPHIC TONGUE INDUCED BY VENETOCLAX IN A PATIENT WITH CHRONIC LYMPHOCYTIC LEUKEMIA. 61
31320968 2019
30
Association between geographic tongue and psoriasis: A systematic review and meta-analyses. 61
30739339 2019
31
Erythematous and Vascular Oral Mucosal Lesions: A Clinicopathologic Review of Red Entities. 61
30693460 2019
32
Prevalence of Dental Enamel Defects, Aphthous-Like Ulcers and Other Oral Manifestations in Celiac Children and Adolescents: A Comparative Study. 61
31283894 2019
33
Geographic tongue that responds to the treatment of pregabalin: Can it be a new treatment choice? 61
30365234 2019
34
Geographic stomatitis with palate involvement. 61
31644619 2019
35
Comparing the Frequency of Some Oral Lesions in Prediabetic and Healthy Individuals: Is There Any Difference? 61
32133095 2019
36
Determining salivary and serum levels of iron, zinc and vitamin B12 in patients with geographic tongue. 61
31857869 2019
37
Geographic tongue: Predisposing factors, diagnosis and treatment. A systematic review. 61
29903400 2018
38
Geographic tongue induced by angiogenesis inhibitors. 61
30336939 2018
39
GEOGRAPHIC TONGUE: PATTERN OF PRESENTATION IN A SOUTH WESTERN NIGERIAN TEACHING HOSPITAL. 61
31217770 2018
40
Effectiveness of the Tacrolimus Swish-and-Spit Treatment Regimen in Patients With Geographic Tongue. 61
30419108 2018
41
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails. 61
30374901 2018
42
Tongue psoriasis: Clinical aspects and analysis of epidemiological associations in 313 children, with a systematic literature review. 61
29773283 2018
43
Frequency of Pathologic Changes in the Oral Cavity in Patients Subjected to Long-term Pharmacologic Immunosuppressive Therapy After Kidney, Liver, and Hematopoietic Cell Transplantation. 61
30177132 2018
44
Epidemiology of oral mucosal lesions in Slovenia. 61
30210036 2018
45
The burden of Diabetes, Its Oral Complications and Their Prevention and Management. 61
30159091 2018
46
An infant with generalized pustular psoriasis and geographic tongue had a heterozygous IL36RN mutation and IgG2 deficiency. 61
29454537 2018
47
A pragmatic evidence-based clinical management algorithm for burning mouth syndrome. 61
29750091 2018
48
Acrodermatitis continua of Hallopeau and geographic tongue are variants of pustular psoriasis. 61
29687071 2018
49
Geographic tonguelike presentation in a child with pityriasis rosea: Case report and review of oral manifestations of pityriasis rosea. 61
29436009 2018
50
Oral features in patients with psoriasis: an observational study. 61
29307171 2018
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Variations for Geographic Tongue

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Expression for Geographic Tongue

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Search GEO for disease gene expression data for Geographic Tongue.
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Pathways for Geographic Tongue

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Pathways related to Geographic Tongue according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Phagosome 36
10.98 HLA-DQB1 HLA-A DYNC2H1
2
Intraflagellar transport 65
10.57 DYNLT2B DYNC2H1
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GO Terms for Geographic Tongue

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Cellular components related to Geographic Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ER to Golgi transport vesicle membrane GO:0012507 9.16 HLA-DQB1 HLA-A
2 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-A
3 cytoplasmic dynein complex GO:0005868 8.62 DYNLT2B DYNC2H1

Biological processes related to Geographic Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.46 IL36RN IL1RL2 HLA-DQB1 HLA-A
2 antigen processing and presentation GO:0019882 8.96 HLA-DQB1 HLA-A
3 intraciliary retrograde transport GO:0035721 8.62 DYNLT2B DYNC2H1

Molecular functions related to Geographic Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-A
2 dynein intermediate chain binding GO:0045505 8.62 DYNLT2B DYNC2H1
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Sources for Geographic Tongue

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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