MCID: GGR001
MIFTS: 52

Geographic Tongue

Categories: Rare diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Geographic Tongue

MalaCards integrated aliases for Geographic Tongue:

Name: Geographic Tongue 12 76 53 15
Glossitis, Benign Migratory 44 73
Benign Migratory Glossitis 12 53
Glossitis Areata Exfoliativa 12
Erythema Chronicum Migrans 73
Ectopic Geographic Tongue 53
Pityriasis Linguae 12
Erythema Migrans 53

Classifications:



External Ids:

Disease Ontology 12 DOID:1455
ICD10 33 K14.1
ICD9CM 35 529.1
MeSH 44 D005929
NCIt 50 C84588

Summaries for Geographic Tongue

NIH Rare Diseases : 53 Geographic tongue is a condition that causes chronic and recurrent lesions on the tongue that resemble psoriasis of the skin. It is characterized by pink to red, slightly depressed lesions with irregular, elevated, white or yellow borders. The lesions may also occur in the mucosa of the mouth and labia; this condition is called "areata migrans" because these lesions typically disappear from one area and show up in another. The tongue is normally covered with tiny, pinkish-white bumps (papillae), which are actually short, fine, hair-like projections. With geographic tongue, patches on the surface of the tongue are missing papillae and appear as smooth, red "islands," often with slightly raised borders. These patches (lesions) give the tongue a map-like, or geographic, appearance. In most cases there are no symptoms but sometimes it is painful when inflamed. The cause of this condition is unknown. Many researchers think it is linked with psoriasis, but more research is needed to better understand the connection. Also, hereditary and environmental factors may be involved. The condition is benign and localized, generally requiring no treatment except reassurance. If painful, it may be treated with steroid gels or antihistamine mouth rinses. 

MalaCards based summary : Geographic Tongue, also known as glossitis, benign migratory, is related to pustulosis of palm and sole and pustular psoriasis, and has symptoms including exanthema, glossalgia and erythema of the eyelids. An important gene associated with Geographic Tongue is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Cytokine Signaling in Immune system. The drugs Doxycycline and Penicillin V have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and testes, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 An atrophic glossitis that is characterized as an inflammatory condition of the mucous membrane of the tongue, usually on the dorsal surface.

Wikipedia : 76 Geographic tongue, also known by several other terms,[note 1] is an inflammatory condition of the mucous... more...

Related Diseases for Geographic Tongue

Diseases related to Geographic Tongue via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 pustulosis of palm and sole 30.0 IL36RN TNF
2 pustular psoriasis 30.0 IL36RN TNF
3 celiac disease 1 27.5 CD79A HLA-A HLA-DQB1 HLA-DQB2 TGM2 TNF
4 lyme disease 11.6
5 fissured tongue 11.5
6 limbic encephalitis with lgi1 antibodies 10.9 HLA-DQB1 HLA-DRB1
7 phenytoin or carbamazepine toxicity 10.8 HLA-A HLA-B
8 recurrent hypersomnia 10.8 HLA-DQB1 HLA-DQB2
9 metal allergy 10.8 HLA-DQB1 HLA-DRB1
10 focal epithelial hyperplasia 10.8 HLA-DQB1 HLA-DRB1
11 hypersomnia 10.8 HLA-DQB1 HLA-DRB1
12 atrial tachyarrhythmia with short pr interval 10.7 HLA-A HLA-B
13 lichen planopilaris 10.7 HLA-DQB1 HLA-DRB1
14 type ii mixed cryoglobulinemia 10.7 HLA-DQB1 HLA-DRB1
15 postherpetic neuralgia 10.6 HLA-A HLA-B HLA-DRB1
16 idiopathic inflammatory myopathy 10.6 HLA-B HLA-DRB1
17 autoimmune hepatitis 10.6 HLA-A HLA-DQB1 HLA-DRB1
18 pars planitis 10.5 HLA-A HLA-B HLA-DRB1
19 atrophic glossitis 10.5 HLA-A HLA-DQB2 IL36RN WHRN
20 glaucomatocyclitic crisis 10.5 HLA-A HLA-B HLA-C
21 histoplasmosis 10.5 HLA-A HLA-B HLA-DRB1
22 pure red-cell aplasia 10.5 HLA-A HLA-B HLA-DRB1
23 acute disseminated encephalomyelitis 10.5 HLA-B HLA-DQB1 HLA-DRB1
24 human herpesvirus 8 10.5 HLA-A HLA-B HLA-C
25 recurrent respiratory papillomatosis 10.4 EGFR HLA-DQB1 HLA-DRB1
26 beryllium disease 10.3 HLA-DQB1 HLA-DRB1 TNF
27 autoimmune pancreatitis 10.3 HLA-DQB1 HLA-DRB1 TNF
28 chronic beryllium disease 10.3 HLA-DQB1 HLA-DRB1 TNF
29 lichen sclerosus 10.3 HLA-DQB1 HLA-DRB1 TNF
30 rheumatic heart disease 10.3 HLA-A HLA-DRB1 TNF
31 vogt-koyanagi-harada disease 10.3 HLA-A HLA-B HLA-DQB1 HLA-DRB1
32 oligoarticular juvenile idiopathic arthritis 10.3 HLA-DQB1 HLA-DRB1 TNF
33 dengue hemorrhagic fever 10.3 HLA-A HLA-DRB1 TNF
34 severe hemophilia a 10.3 HLA-DQB1 HLA-DRB1 TNF
35 sympathetic ophthalmia 10.2 HLA-C HLA-DRB1 TNF
36 aphthous stomatitis 10.2 HLA-A HLA-B TNF
37 microscopic polyangiitis 10.2 HLA-B HLA-DRB1 TNF
38 severe cutaneous adverse reaction 10.2 EPHX1 HLA-A HLA-B HLA-C
39 cytomegalovirus retinitis 10.2 HLA-B HLA-DQB1 TNF
40 melanoma, uveal 10.2 HLA-A HLA-B NME1
41 osteonecrosis of the jaw 10.2 HLA-DQB1 HLA-DRB1 VEGFA
42 anterior uveitis 10.2 HLA-A HLA-B
43 psoriasis 10.1
44 glossitis 10.1
45 leishmaniasis 10.1 HLA-DQB1 HLA-DRB1 TNF
46 cholangitis 10.1 HLA-B HLA-DRB1 TNF
47 rheumatic disease 10.1 HLA-B HLA-DRB1 TNF
48 myocarditis 10.0 HLA-B HLA-DQB1 TNF
49 spondylitis 10.0 HLA-B HLA-C TNF
50 juvenile dermatitis herpetiformis 10.0 CD79A HLA-A

Graphical network of the top 20 diseases related to Geographic Tongue:



Diseases related to Geographic Tongue

Symptoms & Phenotypes for Geographic Tongue

UMLS symptoms related to Geographic Tongue:


exanthema, glossalgia, erythema of the eyelids, heliotrope rash

GenomeRNAi Phenotypes related to Geographic Tongue according to GeneCards Suite gene sharing:

26 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.48 HLA-B HLA-C HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.48 CD79A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.48 HLA-B HLA-C HLA-A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.48 HLA-C HLA-B HLA-A EGFR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.48 EGFR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.48 HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.48 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.48 HLA-B HLA-C HLA-A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.48 HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.48 CD79A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.48 HLA-B HLA-C HLA-A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.48 HLA-B HLA-C HLA-A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.48 EGFR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.48 HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.48 EGFR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.48 EGFR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.48 HLA-B HLA-C HLA-A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.48 EGFR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.48 HLA-C
20 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.48 CD79A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.48 HLA-B HLA-C HLA-A
22 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.48 CD79A
23 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.48 HLA-B HLA-C HLA-A CD79A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.48 EGFR
25 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.48 HLA-C

MGI Mouse Phenotypes related to Geographic Tongue:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.56 WHRN CD79A EGFR HLA-DQB1 NME1 THEM5
2 neoplasm MP:0002006 9.17 CD79A EGFR EPHX1 NME1 TGM2 TNF

Drugs & Therapeutics for Geographic Tongue

Drugs for Geographic Tongue (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Not Applicable 564-25-0 54671203
2
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
3
Cefuroxime Approved Phase 4,Not Applicable 55268-75-2 5361202 5479529
4
Amoxicillin Approved, Vet_approved Phase 4,Not Applicable 26787-78-0 33613
5 Anti-Bacterial Agents Phase 4,Phase 1,Phase 2,Not Applicable
6 Anti-Infective Agents Phase 4,Phase 1,Phase 2,Not Applicable
7 Antiparasitic Agents Phase 4,Not Applicable
8 Antiprotozoal Agents Phase 4,Not Applicable
9 Antimalarials Phase 4,Not Applicable
10 penicillins Phase 4
11 cefuroxime axetil Phase 4,Not Applicable
12 Antibiotics, Antitubercular Phase 4,Phase 1,Phase 2,Not Applicable
13
Ceftriaxone Approved Not Applicable 73384-59-5 5479530 5361919
14 Antibodies
15 Immunoglobulins
16 Immunoglobulin A
17 Immunoglobulin G
18 Immunoglobulin M
19 Antitubercular Agents Not Applicable

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed NCT01518192 Phase 4 doxycycline;cefuroxime axetil
2 Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice Completed NCT01368341 Phase 4 Doxycycline;Phenoxymethylpenicillin;Amoxicillin
3 Xenodiagnosis After Antibiotic Treatment for Lyme Disease Recruiting NCT02446626 Phase 1, Phase 2
4 The Relationship Between Allergic Rhinitis and Geographic Tongue Unknown status NCT01454492
5 Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis Unknown status NCT00942006 Not Applicable doxycycline;ceftriaxone
6 Duration of Antibiotic Treatment of Erythema Migrans Completed NCT00910715 Not Applicable doxycycline;doxycycline;placebo
7 Doxycycline in Therapy of Erythema Migrans Completed NCT01475708 Doxycycline
8 Culture Media for Borrelia Burgdorferi Sensu Lato Completed NCT02145754 Not Applicable
9 Searching for Persistence of Infection in Lyme Disease Completed NCT01143558 Early Phase 1
10 Sofia 2 Lyme FIA Whole Blood Clinical Study Completed NCT03238274
11 Cytokines and Chemokines in Erythema Migrans Recruiting NCT02147249 Not Applicable antibiotic treatment
12 Antibiotic Treatment of Multiple Erythema Migrans Recruiting NCT01163994 Not Applicable ceftriaxone;doxycycline
13 Duration of Doxycycline Treatment in EM Patients Recruiting NCT03153267 Not Applicable Doxycycline 100 MG Oral Tablet bid, 7 days;Doxycycline 100 MG Oral Tablet bid, 14 days;Controls without a history of lyme disease.
14 Analysis of Lyme Disease Lesions Recruiting NCT00132327
15 Duration of Doxycycline Treatment in MEM Patients Recruiting NCT03337932 Not Applicable Doxycycline 100 milligram Oral Tablet bid, 7 days;Doxycycline 100 milligram Oral Tablet bid, 14 days;Controls without a history of lyme disease.
16 Lyme Borreliosis and Early Cutaneous Diagnostic Recruiting NCT02414789 Not Applicable
17 Detection of Borrelia Bacteria in Early Stage Lyme Borreliosis Using the T2Lyme Panel Recruiting NCT03581279 Not Applicable
18 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082
19 Lyme Test Indication Combinations (LyTIC) Study Recruiting NCT03201042
20 Erythema Migrans in Elderly Active, not recruiting NCT03371563 Antibiotics
21 Patient's Pretreatment Expectations About Post-Lyme Symptoms Not yet recruiting NCT03462329 Not Applicable Antibiotics (preferentially oral doxycycline 100 mg bid)
22 Next Generation Sequencing Detection of Lyme Disease Not yet recruiting NCT03505879
23 Understanding Tick-borne Diseases Not yet recruiting NCT03501407
24 Investigation of Southern Tick-Associated Rash Illness (STARI) Terminated NCT00358761
25 A Multicenter Study to Evaluate a Borrelia Diagnostic Test in Subjects With Early Stage or Late Stage Lyme Disease Terminated NCT02741609 Not Applicable

Search NIH Clinical Center for Geographic Tongue

Cochrane evidence based reviews: glossitis, benign migratory

Genetic Tests for Geographic Tongue

Anatomical Context for Geographic Tongue

MalaCards organs/tissues related to Geographic Tongue:

41
Tongue, Skin, Testes, Whole Blood

Publications for Geographic Tongue

Articles related to Geographic Tongue:

(show top 50) (show all 57)
# Title Authors Year
1
An infant with generalized pustular psoriasis and geographic tongue had a heterozygous IL36RN mutation and IgG2 deficiency. ( 29454537 )
2018
2
Acrodermatitis continua of Hallopeau and geographic tongue are variants of pustular psoriasis. ( 29687071 )
2018
3
Geographic tongue: Predisposing factors, diagnosis and treatment. A systematic review. ( 29903400 )
2018
4
Geographic tongue: assessment of peripheral nerve status, Langerhans cell, and HLA-DR expression. ( 28757081 )
2017
5
Geographic Tongue. ( 28716459 )
2017
6
Investigation of the clinical features of geographic tongue: unveiling its relationship with oral psoriasis. ( 28188609 )
2017
7
Salivary levels of interleukin-8 and growth factors are modulated in patients with geographic tongue. ( 28178402 )
2017
8
Lingual microbiota profiles of patients with geographic tongue. ( 28839519 )
2017
9
IMAGES IN CLINICAL MEDICINE. Geographic Tongue. ( 26886524 )
2016
10
Geographic tongue and psoriasis: clinical, histopathological, immunohistochemical and genetic correlation - a literature review. ( 27579734 )
2016
11
Oral medicine: Factors associated with geographic tongue and fissured tongue. ( 27388082 )
2016
12
The prevalence of celiac disease in patients with geographic tongue. ( 27131886 )
2016
13
Geographic Tongue. ( 27436616 )
2016
14
Paediatric Geographic Tongue: A Case Report, Review and Recent Updates. ( 27042597 )
2016
15
Geographic tongue associated with sialadenitis. ( 27726175 )
2016
16
Geographic tongue. ( 27505875 )
2016
17
Treatment of Symptomatic Geographic Tongue with Triamcinolone Acetonide Alone and in Combination with Retinoic Acid: A Randomized Clinical Trial. ( 27536325 )
2016
18
Mutations in IL36RN are associated with geographic tongue. ( 27900482 )
2016
19
Factors associated with geographic tongue and fissured tongue. ( 26381370 )
2015
20
Prevalence of Geographic tongue and Related Predisposing Factors in 7-18 Year-Old Students in Kermanshah, Iran 2014. ( 26156909 )
2015
21
Geographic tongue and fissured tongue in 348 patients with psoriasis: correlation with disease severity. ( 25685842 )
2015
22
Psychological parameters associated with geographic tongue: a clinical observation. ( 25482552 )
2015
23
Psychological parameters associated with geographic tongue: a clinical observation. ( 25482551 )
2015
24
A possible relationship of human leucocyte antigens with psoriasis vulgaris and geographic tongue. ( 25176018 )
2014
25
Medical image. A benign glossal lesion. Geographic tongue. ( 24929575 )
2014
26
Relation between psoriasis and geographic tongue. ( 25584342 )
2014
27
Treatment of geographic tongue with topical tacrolimus. ( 25085945 )
2014
28
Immunologic and psychologic parameters associated with geographic tongue. ( 24842481 )
2014
29
Case of the month. Ectopic geographic tongue (erythema migrans). ( 24937889 )
2014
30
Geographic tongue in monozygotic twins. ( 24959517 )
2014
31
Geographic tongue induced by angiogenesis inhibitors. ( 23576484 )
2013
32
Geographic tongue and tenofovir. ( 23598934 )
2013
33
Geographic Tongue and Associated Risk Factors among Iranian Dental Patients. ( 23515238 )
2013
34
Oral and maxillofacial pathology case of the month. Erythema migrans (ectopic migratory glossitis/ectopic geographic tongue). ( 24236384 )
2013
35
The comparison of salivary level of estrogen and progesterone in 1(st) , 2(nd) and 3(rd) trimester in pregnant women with and without geographic tongue. ( 24348617 )
2013
36
Increased prevalence of geographic tongue in burning mouth complaints: a retrospective study. ( 22901641 )
2012
37
Migratory stomatitis (ectopic geographic tongue) on the floor of the mouth. ( 21763590 )
2011
38
Geographic tongue treated with topical tacrolimus. ( 21886753 )
2010
39
Images in clinical medicine. Geographic tongue. ( 19907039 )
2009
40
Allergic contact stomatitis presenting as geographical tongue with pruritus. ( 19207382 )
2009
41
Oral medicine case book 7. Migratory stomatitis and geographic tongue. ( 18689340 )
2008
42
Recurrent geographical tongue and fissured tongue in association with pregnancy. ( 17243991 )
2007
43
Ectopic geographic tongue--a case report. ( 17432777 )
2007
44
Prevalence and risk factors associated with geographic tongue among US adults. ( 16792723 )
2006
45
The prevalence and significance of fissured tongue and geographical tongue in psoriatic patients. ( 16487088 )
2006
46
Geographic tongue: clinical characteristics of 188 cases. ( 15719084 )
2005
47
Geographic tongue: literature review and case reports. ( 16161818 )
2005
48
Painful geographic tongue (benign migratory glossitis) in a child. ( 15482313 )
2004
49
Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. ( 15316160 )
2004
50
Benign migratory glossitis or geographic tongue: an enigmatic oral lesion. ( 12517366 )
2002

Variations for Geographic Tongue

Expression for Geographic Tongue

Search GEO for disease gene expression data for Geographic Tongue.

Pathways for Geographic Tongue

Pathways related to Geographic Tongue according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 CD79A EGFR HLA-A HLA-B HLA-C HLA-DQB1
2
Show member pathways
13.17 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2
3
Show member pathways
12.87 EGFR HLA-A HLA-B HLA-C TNF VEGFA
4
Show member pathways
12.8 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
5
Show member pathways
12.52 EGFR HLA-A HLA-B HLA-C TNF
6
Show member pathways
12.45 CD79A HLA-DQB1 HLA-DQB2 HLA-DRB1
7
Show member pathways
12.45 HLA-A HLA-B HLA-C TNF VEGFA
8
Show member pathways
12.39 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 TNF
9
Show member pathways
12.38 HLA-A HLA-B HLA-C TNF TNFRSF10B
10
Show member pathways
12.29 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
11 12.27 EGFR HLA-A HLA-B HLA-C
12 12.13 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
13
Show member pathways
12.03 HLA-DQB1 HLA-DQB2 HLA-DRB1
14
Show member pathways
11.97 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
15 11.95 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
16 11.84 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1 TNF
17 11.83 EGFR HLA-DQB1 HLA-DQB2 HLA-DRB1
18
Show member pathways
11.82 HLA-DQB1 HLA-DQB2 HLA-DRB1
19 11.81 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
20 11.79 HLA-DQB1 HLA-DQB2 HLA-DRB1
21 11.76 HLA-DQB1 HLA-DRB1 TNF
22 11.71 HLA-DQB1 HLA-DRB1 TNF VEGFA
23 11.43 EGFR TNF VEGFA
24 11.05 HLA-A HLA-B HLA-C

GO Terms for Geographic Tongue

Cellular components related to Geographic Tongue according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.87 EGFR HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2
2 endosome membrane GO:0010008 9.83 EGFR HLA-DQB1 HLA-DQB2 HLA-DRB1
3 early endosome membrane GO:0031901 9.76 EGFR HLA-A HLA-B HLA-C
4 cell surface GO:0009986 9.76 EGFR HLA-A HLA-B HLA-C HLA-DRB1 TNF
5 trans-Golgi network membrane GO:0032588 9.73 HLA-DQB1 HLA-DQB2 HLA-DRB1
6 recycling endosome membrane GO:0055038 9.72 HLA-A HLA-B HLA-C
7 phagocytic vesicle membrane GO:0030670 9.71 HLA-A HLA-B HLA-C
8 endocytic vesicle membrane GO:0030666 9.69 HLA-DQB1 HLA-DQB2 HLA-DRB1
9 transport vesicle membrane GO:0030658 9.67 HLA-DQB1 HLA-DQB2 HLA-DRB1
10 clathrin-coated endocytic vesicle membrane GO:0030669 9.58 HLA-DQB1 HLA-DQB2 HLA-DRB1
11 MHC class II protein complex GO:0042613 9.54 HLA-DQB1 HLA-DQB2 HLA-DRB1
12 MHC class I protein complex GO:0042612 9.43 HLA-A HLA-B HLA-C
13 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
14 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.1 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
15 membrane GO:0016020 10.41 AKTIP CD79A EGFR EPHX1 HLA-A HLA-B
16 plasma membrane GO:0005886 10.25 AKTIP CD79A EGFR HLA-A HLA-B HLA-C
17 endoplasmic reticulum GO:0005783 10.08 EGFR EPHX1 HLA-A HLA-B HLA-C HLA-DQB2

Biological processes related to Geographic Tongue according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.87 CD79A HLA-A HLA-B HLA-C HLA-DQB2 HLA-DRB1
2 immune response GO:0006955 9.81 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
3 positive regulation of protein phosphorylation GO:0001934 9.78 AKTIP EGFR TNF VEGFA
4 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.77 HLA-DQB1 HLA-DQB2 HLA-DRB1
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.76 EGFR TNF VEGFA
6 T cell costimulation GO:0031295 9.75 HLA-DQB1 HLA-DQB2 HLA-DRB1
7 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.74 HLA-A HLA-B HLA-C
8 type I interferon signaling pathway GO:0060337 9.73 HLA-A HLA-B HLA-C
9 positive regulation of MAP kinase activity GO:0043406 9.72 EGFR TNF VEGFA
10 positive regulation of epithelial cell proliferation GO:0050679 9.71 EGFR NME1 VEGFA
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.7 EGFR TGM2 TNF
12 positive regulation of cell adhesion GO:0045785 9.63 TGM2 TNF VEGFA
13 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.58 HLA-A HLA-B HLA-C
14 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.54 HLA-DQB1 HLA-DQB2 HLA-DRB1
15 protection from natural killer cell mediated cytotoxicity GO:0042270 9.51 HLA-A HLA-B
16 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.49 HLA-DQB1 HLA-DRB1
17 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.43 HLA-DQB1 HLA-DRB1
18 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.43 HLA-A HLA-B HLA-C
19 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1
20 antigen processing and presentation GO:0019882 9.1 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DQB2 HLA-DRB1

Molecular functions related to Geographic Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 9.13 HLA-DQB1 HLA-DQB2 HLA-DRB1
2 peptide antigen binding GO:0042605 9.02 HLA-A HLA-B HLA-C HLA-DQB1 HLA-DRB1
3 protein binding GO:0005515 10.06 AKTIP CD79A EGFR HLA-A HLA-B HLA-C

Sources for Geographic Tongue

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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