MCID: GGR001
MIFTS: 41

Geographic Tongue

Categories: Gastrointestinal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Geographic Tongue

MalaCards integrated aliases for Geographic Tongue:

Name: Geographic Tongue 12 74 52 15 17 32
Glossitis, Benign Migratory 43 71
Benign Migratory Glossitis 12 52
Glossitis Areata Exfoliativa 12
Erythema Chronicum Migrans 71
Ectopic Geographic Tongue 52
Pityriasis Linguae 12
Erythema Migrans 52

Classifications:



External Ids:

Disease Ontology 12 DOID:1455
ICD9CM 34 529.1
MeSH 43 D005929
NCIt 49 C84588
SNOMED-CT 67 59032001
ICD10 32 K14.1
UMLS 71 C0014740 C0017677

Summaries for Geographic Tongue

NIH Rare Diseases : 52 Geographic tongue is a condition that causes chronic and recurrent lesions on the tongue that resemble psoriasis of the skin. It is characterized by pink to red, slightly depressed lesions with irregular, elevated, white or yellow borders. The lesions may also occur in the mucosa of the mouth and labia; this condition is called "areata migrans" because these lesions typically disappear from one area and show up in another. The tongue is normally covered with tiny, pinkish-white bumps (papillae ), which are actually short, fine, hair-like projections. With geographic tongue , patches on the surface of the tongue are missing papillae and appear as smooth, red "islands," often with slightly raised borders. These patches (lesions) give the tongue a map-like, or geographic, appearance. In most cases there are no symptoms but sometimes it is painful when inflamed. The cause of this condition is unknown. Many researchers think it is linked with psoriasis, but more research is needed to better understand the connection. Also, hereditary and environmental factors may be involved. The condition is benign and localized, generally requiring no treatment except reassurance. If painful, it may be treated with steroid gels or antihistamine mouth rinses.

MalaCards based summary : Geographic Tongue, also known as glossitis, benign migratory, is related to pustulosis of palm and sole and alopecia areata, and has symptoms including exanthema, erythema of the eyelids and glossalgia. An important gene associated with Geographic Tongue is IL36RN (Interleukin 36 Receptor Antagonist), and among its related pathways/superpathways are Interferon gamma signaling and Human T-cell leukemia virus 1 infection. The drugs Doxycycline and Cefuroxime have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and whole blood, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 An atrophic glossitis that is characterized as an inflammatory condition of the mucous membrane of the tongue, usually on the dorsal surface.

Wikipedia : 74 Geographic tongue, also known by several other terms,[note 1] is an inflammatory condition of the mucous... more...

Related Diseases for Geographic Tongue

Diseases related to Geographic Tongue via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 pustulosis of palm and sole 30.5 IL36RN IL1RL2 CARD14
2 alopecia areata 29.8 HLA-DQB1 HLA-C HLA-A
3 celiac disease 1 29.6 HLA-DQB1 HLA-C HLA-A
4 acrodermatitis 29.4 IL36RN IL1RL2 CARD14
5 psoriasis 29.4 IL36RN HLA-C HLA-A CARD14
6 lyme disease 12.1
7 fissured tongue 11.8
8 acrodermatitis chronica atrophicans 10.6
9 glossitis 10.5
10 cellulitis 10.3
11 atrioventricular block 10.3
12 annular erythema 10.2
13 tick-borne encephalitis 10.2
14 facial paralysis 10.2
15 arthritis 10.2
16 dermatophytosis 10.2
17 cytokine deficiency 10.2
18 median rhomboid glossitis 10.2
19 moyamoya angiopathy 10.2 HLA-DQB1 HLA-A
20 red cell aplasia 10.2 HLA-DQB1 HLA-A
21 pustular psoriasis 10.1
22 pure red-cell aplasia 10.1 HLA-DQB1 HLA-A
23 autoimmune disease 10.1
24 spotted fever 10.1
25 erysipelas 10.1
26 aseptic meningitis 10.1
27 neutropenia 10.1
28 urticaria 10.1
29 thrombocytopenia 10.1
30 myelitis 10.1
31 syphilis 10.1
32 systemic scleroderma 10.1
33 myocarditis 10.1
34 localized scleroderma 10.1
35 encephalitis 10.1
36 alopecia 10.1
37 47,xyy 10.1
38 cytomegalovirus retinitis 10.1 HLA-DQB1 HLA-A
39 colorectal cancer, hereditary nonpolyposis, type 8 10.1 HLA-C HLA-A
40 hairy tongue 10.1
41 stomatitis 10.1
42 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 HLA-C HLA-A
43 ige responsiveness, atopic 10.0
44 bronchitis 10.0
45 seborrheic dermatitis 10.0
46 birdshot chorioretinopathy 10.0 HLA-C HLA-A
47 familial cold autoinflammatory syndrome 2 10.0 IL1RL2 CARD14
48 pfeiffer syndrome 10.0
49 lichen sclerosus et atrophicus 10.0
50 chromosome 2q35 duplication syndrome 10.0

Graphical network of the top 20 diseases related to Geographic Tongue:



Diseases related to Geographic Tongue

Symptoms & Phenotypes for Geographic Tongue

UMLS symptoms related to Geographic Tongue:


exanthema, erythema of the eyelids, glossalgia, heliotrope rash

GenomeRNAi Phenotypes related to Geographic Tongue according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.81 HLA-A HLA-C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.81 CARD14
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.81 HLA-A HLA-C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.81 CARD14
5 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.81 HLA-A HLA-C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.81 CARD14
7 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.81 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.81 CARD14
9 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.81 HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.81 CARD14
11 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.81 HLA-C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.81 HLA-A HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.81 HLA-A HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.81 CARD14
15 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.81 HLA-C
16 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.81 CARD14
17 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.81 HLA-A HLA-C
18 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.81 HLA-C
19 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.81 CARD14
20 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.81 HLA-A HLA-C
21 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.81 CARD14 HLA-A HLA-C
22 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.81 HLA-C

Drugs & Therapeutics for Geographic Tongue

Drugs for Geographic Tongue (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
3
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
4
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
5 Antiprotozoal Agents Phase 4
6 Antiparasitic Agents Phase 4
7 Antimalarials Phase 4
8 cefuroxime axetil Phase 4
9 penicillins Phase 4
10 Anti-Bacterial Agents Phase 1, Phase 2
11 Antibiotics, Antitubercular Phase 1, Phase 2
12 Anti-Infective Agents Phase 1, Phase 2
13
Ceftriaxone Approved 73384-59-5 5479530 5361919
14 Antitubercular Agents
15 Immunoglobulins
16 Antibodies

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Tick Borne Diseases in Norwegian General Practice. A Randomized, Controlled Trial for Treatment of Erythema Migrans in Norwegian General Practice. A Comparison of Phenoxymethylpenicillin, Amoxicillin and Doxycycline. Completed NCT01368341 Phase 4 Doxycycline;Phenoxymethylpenicillin;Amoxicillin
2 Risk Factors for Failure of Erythema Migrans Treatment - Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Adult Patients With Erythema Migrans: Clinical and Microbiological Outcome. Completed NCT01518192 Phase 4 doxycycline;cefuroxime axetil
3 Effectiveness of Mucolox® and Clonazepam in Treatment of Burning Mouth Syndrome Withdrawn NCT02690844 Phase 4 Clonazepam mixed with Mucolox®;Mucolox® alone;Clonazepam
4 Xenodiagnosis After Antibiotic Treatment for Lyme Disease - Phase II Study Recruiting NCT02446626 Phase 1, Phase 2
5 Comparison of Ceftriaxone and Doxycycline for Treatment of Multiple Erythema Migrans Unknown status NCT01163994 ceftriaxone;doxycycline
6 The Relationship Between Allergic Rhinitis and Geographic Tongue Unknown status NCT01454492
7 Doxycycline and Ceftriaxone in Patients With Suspected Early Lyme Neuroborreliosis and Normal CSF Cell Count. Unknown status NCT00942006 doxycycline;ceftriaxone
8 Duration of Antibiotic Treatment of Erythema Migrans. A Randomized Clinical Trial. Completed NCT00910715 doxycycline;doxycycline;placebo
9 Comparison of Two Culture Media for Cultivation of Borrelia Burgdorferi Sensu Lato Completed NCT02145754
10 Comparison of Doxycycline and Cefuroxime Axetil in Patients With Erythema Migrans Completed NCT03584919 doxycycline;Cefuroxime Axetil 500Mg Tab
11 Inflammatory Responses in Borrelia Afzelii Culture Positive Patients With Early Disseminated or Early Localized Lyme Borreliosis Completed NCT03980015
12 Doxycycline in Therapy of Erythema Migrans - do the Accompanying Symptoms Influence the Outcome? Completed NCT01475708 Doxycycline
13 Analysis of Erythema Migrans Lesions Completed NCT00132327
14 Clinical Course, Serologic Response and Long-term Outcome in Elderly Patients With Early Lyme Borreliosis Completed NCT03371563 Antibiotics
15 Sofia 2 Lyme FIA Whole Blood Clinical Study Completed NCT03238274
16 Searching for Persistence of Infection in Lyme Disease Completed NCT01143558 Early Phase 1
17 Inflammatory Proteins, Gene Polymorphisms, and Transcriptome Profiles in Patients With Erythema Migrans Recruiting NCT02147249 antibiotic treatment
18 Different Duration and Dosing of Amoxicillin in Patients With Erythema Migrans. A Randomized Clinical Trial. Recruiting NCT03966014 EM-amoxicillin 3 x 10 days;EM-amoxicillin 3 x 14 days;EM-amoxicillin 2 x 14 days
19 Inflammatory Proteins, Gene Polymorphisms, and Transcriptome Profiles in Patients With Erythema Migrans Recruiting NCT03956212 Doxycycline 7 days;Doxycycline 14 days
20 Impact of Patient's Pretreatment Expectations on Treatment Outcome of Early Lyme Borreliosis Recruiting NCT03462329 Antibiotics (preferentially oral doxycycline 100 mg bid)
21 Lyme Borreliosis and Early Cutaneous Diagnostic Recruiting NCT02414789
22 Next Generation Sequencing to Detect Borrelia Burgdorferi DNA in the Blood of Pediatric Patients With Lyme Disease Recruiting NCT03505879
23 Duration of Doxycycline Treatment in Patients With Multiple Erythema Migrans (MEM). A Randomized Clinical Trial Recruiting NCT03337932 Doxycycline 100 milligram Oral Tablet bid, 7 days;Doxycycline 100 milligram Oral Tablet bid, 14 days;Controls without a history of lyme disease.
24 Detection of Borrelia Bacteria in Early Stage Lyme Borreliosis Using the T2Lyme Panel Recruiting NCT03581279
25 DIVERSITY OF BORRELIA SPECIES INVOLVED IN CUTANEOUS MANIFESTATIONS OF LYME BORRELIOSIS IN FRANCE Recruiting NCT00576082
26 One-Health Approach to Identify Threat Posed by Tick-borne Pathogens Responsible of Unexplained Infectious Syndrome in Humans Recruiting NCT03501407
27 Novel Diagnostics for Early Lyme Disease Recruiting NCT03963635
28 Duration of Doxycycline Treatment in Patients With Erythema Migrans (EM). A Randomized Clinical Trial. Active, not recruiting NCT03153267 Doxycycline 100 MG Oral Tablet bid, 7 days;Doxycycline 100 MG Oral Tablet bid, 14 days;Controls without a history of lyme disease.
29 Comparison of Immunofluorescence Assay (IFA) and Chemiluminiscence Immunoassay (LIAISON®) for Diagnosis of Early Disseminated Lyme Borreliosis in Children, Younger Than 18 Years Not yet recruiting NCT03798704
30 An Intervention in a Primary Healthcare Setting to Reduce Lyme Neuroborreliosis Treatment Delay Not yet recruiting NCT03820999
31 A Retrospective Analysis of Oral and Maxillofacial Pathological Lesions in Egyptian Children Not yet recruiting NCT04074395
32 Transcranial Direct Current Stimulation (tDCS) for Cognitive Deficit, Fatigue and Pain in Patients With Post Treatment Lyme Disease Syndrome Suspended NCT03500770
33 Investigation of Southern Tick-Associated Rash Illness (STARI) Terminated NCT00358761

Search NIH Clinical Center for Geographic Tongue

Cochrane evidence based reviews: glossitis, benign migratory

Genetic Tests for Geographic Tongue

Anatomical Context for Geographic Tongue

MalaCards organs/tissues related to Geographic Tongue:

40
Tongue, Skin, Whole Blood, Salivary Gland, Kidney, Liver

Publications for Geographic Tongue

Articles related to Geographic Tongue:

(show top 50) (show all 267)
# Title Authors PMID Year
1
Feeding problems and gastrointestinal diseases in Down syndrome. 61
31784293 2020
2
Geographic tongue severity index: A new and clinical scoring system. 61
31974034 2020
3
Increased levels of calprotectin in the saliva of patients with geographic tongue. 61
31845422 2019
4
Photobiomodulation in Oral Medicine. 61
31873066 2019
5
Evaluation of the Th17 pathway in psoriasis and geographic tongue. 61
31789253 2019
6
Geographic stomatitis: An enigmatic condition with multiple clinical presentations. 61
31636878 2019
7
Red patches on the tongue with white borders • history of geographic tongue • incompletely treated celiac disease • Dx? 61
31532821 2019
8
Genetic and developmental disorders of the oral mucosa: Epidemiology; molecular mechanisms; diagnostic criteria; management. 61
31090139 2019
9
Association of geographic tongue and fissured tongue with ABO blood group among adult psoriasis patients: a novel study from a tertiary care hospital in Saudi Arabia. 61
30902460 2019
10
World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review. 61
31034120 2019
11
Geographic Tongue: What a Dermatologist Should Know. 61
31005233 2019
12
Association between geographic tongue and psoriasis: A systematic review and meta-analyses. 61
30739339 2019
13
GEOGRAPHIC TONGUE INDUCED BY VENETOCLAX IN A PATIENT WITH CHRONIC LYMPHOCYTIC LEUKEMIA. 61
31320968 2019
14
Erythematous and Vascular Oral Mucosal Lesions: A Clinicopathologic Review of Red Entities. 61
30693460 2019
15
Prevalence of Dental Enamel Defects, Aphthous-Like Ulcers and Other Oral Manifestations in Celiac Children and Adolescents: A Comparative Study. 61
31283894 2019
16
Geographic tongue that responds to the treatment of pregabalin: Can it be a new treatment choice? 61
30365234 2019
17
Determining salivary and serum levels of iron, zinc and vitamin B12 in patients with geographic tongue. 61
31857869 2019
18
Geographic stomatitis with palate involvement. 61
31644619 2019
19
GEOGRAPHIC TONGUE: PATTERN OF PRESENTATION IN A SOUTH WESTERN NIGERIAN TEACHING HOSPITAL. 61
31217770 2018
20
Effectiveness of the Tacrolimus Swish-and-Spit Treatment Regimen in Patients With Geographic Tongue. 61
30419108 2018
21
Geographic tongue induced by angiogenesis inhibitors. 61
30336939 2018
22
Geographic tongue: Predisposing factors, diagnosis and treatment. A systematic review. 61
29903400 2018
23
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails. 61
30374901 2018
24
Tongue psoriasis: Clinical aspects and analysis of epidemiological associations in 313 children, with a systematic literature review. 61
29773283 2018
25
Frequency of Pathologic Changes in the Oral Cavity in Patients Subjected to Long-term Pharmacologic Immunosuppressive Therapy After Kidney, Liver, and Hematopoietic Cell Transplantation. 61
30177132 2018
26
Epidemiology of oral mucosal lesions in Slovenia. 61
30210036 2018
27
The burden of Diabetes, Its Oral Complications and Their Prevention and Management. 61
30159091 2018
28
An infant with generalized pustular psoriasis and geographic tongue had a heterozygous IL36RN mutation and IgG2 deficiency. 61
29454537 2018
29
Acrodermatitis continua of Hallopeau and geographic tongue are variants of pustular psoriasis. 61
29687071 2018
30
A pragmatic evidence-based clinical management algorithm for burning mouth syndrome. 61
29750091 2018
31
Geographic tonguelike presentation in a child with pityriasis rosea: Case report and review of oral manifestations of pityriasis rosea. 61
29436009 2018
32
Oral features in patients with psoriasis: an observational study. 61
29307171 2018
33
[Oral allergies]. 61
30320994 2018
34
Tooth Wear Is Frequent in Adult Patients with Celiac Disease. 61
29207559 2017
35
Geographic Tongue. 61
28716459 2017
36
Prevalence of Oral Mucosal Lesions and Their Association with Severity of Psoriasis among Psoriatic Patients Referred To Dermatology Clinic: A Cross-Sectional Study in Kashan/Iran. 61
29362631 2017
37
Digestive system in psoriasis: an update. 61
28905102 2017
38
Geographic tongue: assessment of peripheral nerve status, Langerhans cell, and HLA-DR expression. 61
28757081 2017
39
Salivary levels of interleukin-8 and growth factors are modulated in patients with geographic tongue. 61
28178402 2017
40
Geographic tongue associated with sialadenitis. 61
27726175 2017
41
Oral mucosal lesions in teenagers: a cross-sectional study. 61
28569171 2017
42
Investigation of the clinical features of geographic tongue: unveiling its relationship with oral psoriasis. 61
28188609 2017
43
[Atypical scurvy associated with anorexia nervosa]. 61
27502755 2017
44
Mutations in IL36RN are associated with geographic tongue. 61
27900482 2017
45
The Journey of "Geographic Atrophy" through Past, Present, and Future. 61
28076857 2017
46
Geographic Tongue. 61
27436616 2017
47
Lingual microbiota profiles of patients with geographic tongue. 61
28839519 2017
48
The prevalence of celiac disease in patients with geographic tongue. 61
27131886 2016
49
Prevalence and distribution of oral mucosal non-malignant lesions in the western Sicilian population. 61
27374359 2016
50
[Melkersson Rosenthal syndrome. Report of two pediatric cases]. 61
27399021 2016

Variations for Geographic Tongue

Expression for Geographic Tongue

Search GEO for disease gene expression data for Geographic Tongue.

Pathways for Geographic Tongue

Pathways related to Geographic Tongue according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.99 HLA-DQB1 HLA-C HLA-A
2 11.77 HLA-DQB1 HLA-C HLA-A
3 11.31 HLA-DQB1 HLA-C HLA-A
4 10.97 HLA-DQB1 HLA-C HLA-A
5 10.55 HLA-C HLA-A

GO Terms for Geographic Tongue

Cellular components related to Geographic Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class I protein complex GO:0042612 9.16 HLA-C HLA-A
2 ER to Golgi transport vesicle membrane GO:0012507 9.13 HLA-DQB1 HLA-C HLA-A
3 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-DQB1 HLA-C HLA-A

Biological processes related to Geographic Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.67 IL36RN HLA-DQB1 HLA-C HLA-A
2 immune response GO:0006955 9.56 IL36RN HLA-DQB1 HLA-C HLA-A
3 positive regulation of interleukin-6 production GO:0032755 9.4 IL36RN IL1RL2
4 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.32 HLA-C HLA-A
5 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.16 HLA-C HLA-A
6 interferon-gamma-mediated signaling pathway GO:0060333 9.13 HLA-DQB1 HLA-C HLA-A
7 antigen processing and presentation GO:0019882 8.8 HLA-DQB1 HLA-C HLA-A

Molecular functions related to Geographic Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.8 HLA-DQB1 HLA-C HLA-A

Sources for Geographic Tongue

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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