MCID: GRM001
MIFTS: 29

Germ Cell and Embryonal Cancer

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Germ Cell and Embryonal Cancer

MalaCards integrated aliases for Germ Cell and Embryonal Cancer:

Name: Germ Cell and Embryonal Cancer 12 15
Germ Cell and Embryonal Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3095
MeSH 43 D009373
UMLS 71 C0027658

Summaries for Germ Cell and Embryonal Cancer

Disease Ontology : 12 A germ cell cancer that is derives from a mixture of germs cells and embryonal cells.

MalaCards based summary : Germ Cell and Embryonal Cancer, also known as germ cell and embryonal neoplasm, is related to teratoma and trophoblastic neoplasm. An important gene associated with Germ Cell and Embryonal Cancer is MIR371A (MicroRNA 371a), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Human Embryonic Stem Cell Pluripotency. The drugs Pembrolizumab and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Germ Cell and Embryonal Cancer

Diseases related to Germ Cell and Embryonal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 teratoma 33.1 SOX2 POU5F1 AFP
2 trophoblastic neoplasm 11.4
3 pediatric testicular germ cell tumor 10.7 POU5F1 AFP
4 central nervous system germinoma 10.7 POU5F1 MIR302C MIR302A
5 childhood endodermal sinus tumor 10.7 MIR371A MIR302A AFP
6 mixed germ cell cancer 10.7 MIR371A MIR302A AFP
7 ovarian endodermal sinus tumor 10.7 POU5F1 AFP
8 ovarian embryonal carcinoma 10.7 SOX2 POU5F1 AFP
9 parkinson disease 17 10.7 SOX2 POU5F1 NANOG
10 spermatogenic failure, y-linked, 1 10.7 POU5F1 MYC KLF4
11 intratubular embryonal carcinoma 10.7 POU5F1 AFP
12 ovarian primitive germ cell tumor 10.7 POU5F1 AFP
13 ovarian germ cell cancer 10.7 POU5F1 MIR302C AFP
14 germinoma 10.7 POU5F1 MIR371A MIR302A AFP
15 dysgerminoma of ovary 10.6 POU5F1 NANOG MIR371A AFP
16 mixed cell type cancer 10.6 LCOR H2AC18 AFP
17 macular degeneration, age-related, 7 10.6 SOX2 POU5F1 NANOG KLF4
18 pediatric germ cell cancer 10.6 MIR371A MIR302C MIR302A AFP
19 mediastinal malignant lymphoma 10.6 KDM4C FUT4
20 dysgerminoma 10.6 POU5F1 MIR371A MIR302C AFP
21 central nervous system benign neoplasm 10.6 LCOR KDM4C H2AC18
22 testicular germ cell tumor 10.6 MIR373 MIR371A AFP
23 rhabdoid cancer 10.6 MYC KDM4C H2AC18
24 colonic benign neoplasm 10.6 MYC KDM4C H2AC18
25 tyrosinemia 10.6 SOX2 POU5F1 NANOG AFP
26 non-gestational choriocarcinoma 10.6 MIR302C AFP
27 central nervous system hematologic cancer 10.6 MYC LCOR KDM4C
28 pre-malignant neoplasm 10.6 MYC LCOR H2AC18
29 juvenile type testicular granulosa cell tumor 10.6 MIR302C AFP
30 mediastinal gray zone lymphoma 10.6 KDM4C FUT4
31 hepatic angiomyolipoma 10.6 MYC AFP
32 in situ carcinoma 10.6 MYC LCOR H2AC18
33 testicular granulosa cell tumor 10.6 MIR302C AFP
34 hypotrichosis 1 10.6 MYC KDM4C H2AC18
35 central nervous system germ cell tumor 10.6 POU5F1 AFP
36 ovarian germ cell teratoma 10.6 MIR302C AFP
37 hodgkin's lymphoma, nodular sclerosis 10.6 KDM4C FUT4
38 lymphangioma 10.6 MYC KDM4C H2AC18
39 ovarian gonadoblastoma 10.6 POU5F1 AFP
40 placenta disease 10.6 MIR371A H2AC18 AFP
41 nut midline carcinoma 10.6 SOX2 MYC KDM4C H2AC18
42 teratocarcinoma 10.6 POU5F1 NANOG MIR302A FGF2
43 brain germinoma 10.6 POU5F1 AFP
44 breast carcinoma in situ 10.6 MYC H2AC18 FGF2
45 infratentorial cancer 10.6 SOX2 MYC KDM4C H2AC18
46 luminal breast carcinoma a 10.6 MYC LCOR KDM4C H2AC18
47 mature b-cell neoplasm 10.6 MYC KDM4C H2AC18
48 retinitis pigmentosa 11 10.6 MYC KDM4C H2AC18
49 bile duct adenocarcinoma 10.6 MYC KDM4C H2AC18 AFP
50 bone sarcoma 10.6 MYC MIR369 KDM4C H2AC18

Graphical network of the top 20 diseases related to Germ Cell and Embryonal Cancer:



Diseases related to Germ Cell and Embryonal Cancer

Symptoms & Phenotypes for Germ Cell and Embryonal Cancer

MGI Mouse Phenotypes related to Germ Cell and Embryonal Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.9 FGF2 FUT4 KDM4C KLF4 LIF LIN28A
2 endocrine/exocrine gland MP:0005379 9.61 AFP KDM4C KLF4 LIF LIN28A MYC
3 reproductive system MP:0005389 9.28 AFP FGF2 KLF4 LIF LIN28A MYC

Drugs & Therapeutics for Germ Cell and Embryonal Cancer

Drugs for Germ Cell and Embryonal Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2 Immunoglobulins Phase 2
3 Antibodies Phase 2
4 Antibodies, Monoclonal Phase 2
5 Antineoplastic Agents, Immunological Phase 2
6 Calamus Phase 2
7 Cola Phase 1
8 Vaccines Phase 1
9 Liver Extracts Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II, Multi-center, Open-label Study of a Conditionally Replicative Adenovirus (DNX-2401) With Pembrolizumab (KEYTRUDA®) for Recurrent Glioblastoma or Gliosarcoma (CAPTIVE/KEYNOTE-192) Active, not recruiting NCT02798406 Phase 2
2 A Phase I Study of Active Immunotherapy With Carcinoembryonic Antigen RNA-Pulsed, Autologous Human Cultured Dendritic Cells in Patients With Metastatic Malignancies Expressing Carcinoembryonic Antigen Completed NCT00004604 Phase 1

Search NIH Clinical Center for Germ Cell and Embryonal Cancer

Genetic Tests for Germ Cell and Embryonal Cancer

Anatomical Context for Germ Cell and Embryonal Cancer

MalaCards organs/tissues related to Germ Cell and Embryonal Cancer:

40
Liver

Publications for Germ Cell and Embryonal Cancer

Variations for Germ Cell and Embryonal Cancer

Expression for Germ Cell and Embryonal Cancer

Search GEO for disease gene expression data for Germ Cell and Embryonal Cancer.

Pathways for Germ Cell and Embryonal Cancer

Pathways related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.43 SOX2 SOX17 POU5F1 NANOG MIR373 MIR302C
2
Show member pathways
12.27 SOX2 POU5F1 NANOG FGF2
3 12.13 SOX2 POU5F1 NANOG LIN28A KLF4 FUT4
4
Show member pathways
12.06 SOX2 POU5F1 NANOG MYC
5 11.96 SOX2 POU5F1 NANOG MYC LIF KLF4
6 11.89 SOX2 NANOG MYC LIF FGF2
7 11.54 SOX2 POU5F1 NANOG MIR302A KLF4
8 11.45 SOX2 SOX17 POU5F1 NANOG MYC LIN28A
9 11.37 MYC MIR373 MIR371A
10 11.36 SOX2 SOX17 POU5F1 NANOG LIN28A FGF2
11
Show member pathways
11.12 SOX2 POU5F1 NANOG LIN28A KLF4 FGF2
12 10.88 SOX2 POU5F1 NANOG
13
Show member pathways
10.63 SOX2 POU5F1 NANOG

GO Terms for Germ Cell and Embryonal Cancer

Cellular components related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.23 SOX2 SOX17 POU5F1 NANOG MYC KLF4
2 nuclear transcription factor complex GO:0044798 9.13 SOX2 SOX17 KLF4

Biological processes related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10.04 SOX2 SOX17 POU5F1 NANOG KLF4 FGF2
2 regulation of transcription by RNA polymerase II GO:0006357 9.99 POU5F1 NANOG MYC LCOR KLF4 KDM4C
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 SOX2 SOX17 POU5F1 NANOG MYC LIF
4 gene silencing by miRNA GO:0035195 9.93 MIR373 MIR371A MIR369 MIR302C MIR302A
5 regulation of gene expression GO:0010468 9.88 SOX2 POU5F1 NANOG MYC KDM4C
6 negative regulation of gene expression GO:0010629 9.86 POU5F1 MYC KLF4 FGF2
7 cytokine-mediated signaling pathway GO:0019221 9.83 SOX2 NANOG MYC LIF FGF2
8 positive regulation of gene expression GO:0010628 9.8 SOX17 POU5F1 MYC LIF KLF4 KDM4C
9 response to wounding GO:0009611 9.67 SOX2 POU5F1 MYC
10 stem cell differentiation GO:0048863 9.58 SOX17 LIN28A LIF
11 regulation of cell differentiation GO:0045595 9.56 SOX17 NANOG LIF KLF4
12 response to growth factor GO:0070848 9.55 SOX2 MYC
13 positive regulation of DNA biosynthetic process GO:2000573 9.52 MYC FGF2
14 cellular response to cycloheximide GO:0071409 9.46 MYC KLF4
15 stem cell population maintenance GO:0019827 9.35 NANOG LIN28A LIF KLF4 KDM4C
16 endodermal cell fate specification GO:0001714 9.33 SOX2 POU5F1 NANOG
17 somatic stem cell population maintenance GO:0035019 9.1 SOX2 POU5F1 NANOG LIN28A KLF4 FGF2

Molecular functions related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.91 SOX2 SOX17 POU5F1 NANOG MYC KLF4
2 sequence-specific DNA binding GO:0043565 9.73 SOX2 SOX17 POU5F1 NANOG MYC KLF4
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.72 SOX2 SOX17 POU5F1 MYC KLF4
4 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.71 MIR373 MIR371A MIR302C MIR302A
5 transcription regulatory region DNA binding GO:0044212 9.67 SOX2 SOX17 NANOG KLF4
6 transcription regulatory region sequence-specific DNA binding GO:0000976 9.55 SOX2 SOX17 POU5F1 NANOG KLF4
7 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.5 SOX2 SOX17 POU5F1 NANOG MYC LCOR
8 miRNA binding GO:0035198 8.8 SOX2 POU5F1 LIN28A

Sources for Germ Cell and Embryonal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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