MCID: GRM001
MIFTS: 35

Germ Cell and Embryonal Cancer

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Germ Cell and Embryonal Cancer

MalaCards integrated aliases for Germ Cell and Embryonal Cancer:

Name: Germ Cell and Embryonal Cancer 12 15
Germ Cell and Embryonal Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3095
MeSH 44 D009373
UMLS 73 C0027658

Summaries for Germ Cell and Embryonal Cancer

Disease Ontology : 12 A germ cell cancer that is derives from a mixture of germs cells and embryonal cells.

MalaCards based summary : Germ Cell and Embryonal Cancer, also known as germ cell and embryonal neoplasm, is related to trophoblastic neoplasm and teratoma. An important gene associated with Germ Cell and Embryonal Cancer is POU5F1 (POU Class 5 Homeobox 1), and among its related pathways/superpathways are Wnt Signaling Pathway and Pluripotency and Mesodermal Commitment Pathway. Affiliated tissues include lung, brain and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Germ Cell and Embryonal Cancer

Diseases related to Germ Cell and Embryonal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 trophoblastic neoplasm 31.9 CDKN1C CSH1 KHDC3L NLRP7 PAM
2 teratoma 31.7 AFP KRT7 MNX1 POU5F1 SOX2 TP53
3 partial hydatidiform mole 10.3 KHDC3L NLRP7
4 brain germinoma 10.3 AFP POU5F1
5 sacrococcygeal teratoma 10.3 AFP MNX1
6 extragonadal germ cell cancer 10.3 AFP POU5F1
7 intrahepatic bile duct adenoma 10.3 AFP KRT7
8 childhood endodermal sinus tumor 10.3 AFP LIN28A
9 central nervous system germ cell tumor 10.3 AFP POU5F1 SOX2
10 embryonal testis carcinoma 10.3 AFP POU5F1
11 hepatic angiomyolipoma 10.2 AFP MYC
12 triploidy 10.2 AFP KHDC3L NLRP7
13 gallbladder signet ring cell adenocarcinoma 10.2 KRT7 MYC
14 renal pelvis adenocarcinoma 10.2 AFP KRT7
15 ovarian germ cell cancer 10.2 AFP KRT7
16 intratubular embryonal carcinoma 10.2 AFP KRT7 POU5F1
17 testicular trophoblastic tumor 10.2 CSH1 CSH2
18 methylmalonic aciduria, cblb type 10.2 KLF4 MYC SOX2
19 malignant teratoma 10.2 AFP POU5F1 TP53
20 mature teratoma 10.2 AFP POU5F1 TP53
21 secretory meningioma 10.2 KLF4 KRT7
22 omphalocele 10.2 AFP CDKN1C MNX1
23 liver lymphoma 10.2 AFP FUT4
24 hydatidiform mole, recurrent, 1 10.2 CDKN1C KHDC3L NLRP7
25 lung acinar adenocarcinoma 10.2 KRT7 MYC
26 epithelioid trophoblastic tumor 10.2 CSH1 KRT7
27 malignant spiradenoma 10.2 KRT7 TP53
28 sternum cancer 10.2 AFP FUT4
29 phosphoglycerate dehydrogenase deficiency 10.2 NANOG POU5F1 SOX2
30 vulvar intraepithelial neoplasia 10.2 KRT7 TP53
31 choriocarcinoma of ovary 10.2 CSH1 CSH2
32 bile duct cystadenocarcinoma 10.2 AFP KRT7
33 testicular infarct 10.2 AFP FUT4 POU5F1
34 rh isoimmunization 10.2 AFP CSH1 CSH2
35 central nervous system cancer 10.2 MYC SOX2 TP53
36 acinar cell carcinoma 10.2 AFP KRT7 TP53
37 bile duct adenocarcinoma 10.2 AFP KRT7 TP53
38 central nervous system primitive neuroectodermal neoplasm 10.1 LIN28A TP53
39 ovarian embryonal carcinoma 10.1 AFP NANOG POU5F1 SOX2
40 intrahepatic cholangiocarcinoma 10.1 AFP KRT7 TP53
41 extragonadal seminoma 10.1 AFP NANOG POU5F1 SOX2
42 maturity-onset diabetes of the young, type 8, with exocrine dysfunction 10.1 KLF4 NANOG POU5F1 SOX2
43 malignant leydig cell tumor 10.1 KRT7 POU5F1
44 ocular cancer 10.1 MYC POU5F1 SOX2 TP53
45 chronic salpingitis 10.1 CSH1 CSH2 TP53
46 bladder carcinoma in situ 10.1 KRT7 TP53
47 endocrine gland cancer 10.1 AFP MYC TP53
48 male reproductive organ cancer 10.1 DIO3 MYC TP53
49 male reproductive system disease 10.1 DIO3 MYC TP53
50 reproductive system disease 10.1 DIO3 MYC TP53

Graphical network of the top 20 diseases related to Germ Cell and Embryonal Cancer:



Diseases related to Germ Cell and Embryonal Cancer

Symptoms & Phenotypes for Germ Cell and Embryonal Cancer

GenomeRNAi Phenotypes related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.47 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.47 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.47 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.47 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.47 KRT7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.47 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.47 AFP KRT7 POU5F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.47 AFP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.47 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.47 KRT7 POU5F1

MGI Mouse Phenotypes related to Germ Cell and Embryonal Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.03 DIO3 FUT4 KLF4 KRT7 LIN28A MNX1
2 endocrine/exocrine gland MP:0005379 9.81 AFP KLF4 LIN28A MNX1 MYC POU5F1
3 mortality/aging MP:0010768 9.77 AFP DIO3 KLF4 LGALS1 LIN28A MNX1
4 reproductive system MP:0005389 9.36 AFP DIO3 KHDC3L KLF4 LGALS1 LIN28A

Drugs & Therapeutics for Germ Cell and Embryonal Cancer

Search Clinical Trials , NIH Clinical Center for Germ Cell and Embryonal Cancer

Genetic Tests for Germ Cell and Embryonal Cancer

Anatomical Context for Germ Cell and Embryonal Cancer

MalaCards organs/tissues related to Germ Cell and Embryonal Cancer:

41
Lung, Brain, Kidney, Liver, Bone, Ovary, Testis

Publications for Germ Cell and Embryonal Cancer

Variations for Germ Cell and Embryonal Cancer

Expression for Germ Cell and Embryonal Cancer

Search GEO for disease gene expression data for Germ Cell and Embryonal Cancer.

Pathways for Germ Cell and Embryonal Cancer

GO Terms for Germ Cell and Embryonal Cancer

Cellular components related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.02 KLF4 MYC POU5F1 TP53 ZFP42

Biological processes related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.86 MYC NANOG SOX2 TP53
2 transcription by RNA polymerase II GO:0006366 9.85 KLF4 MYC NANOG POU5F1 SOX2 TP53
3 regulation of gene expression GO:0010468 9.8 MYC NANOG POU5F1 SOX2
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 CSH1 CSH2 TP53
5 negative regulation of transcription by RNA polymerase II GO:0000122 9.7 CDKN1C KLF4 MYC POU5F1 SOX2 TP53
6 response to wounding GO:0009611 9.69 MYC POU5F1 SOX2
7 cellular response to organic cyclic compound GO:0071407 9.63 KLF4 LGALS1 MYC
8 stem cell population maintenance GO:0019827 9.61 KLF4 LIN28A NANOG
9 animal organ development GO:0048513 9.58 CSH1 CSH2
10 response to growth factor GO:0070848 9.57 MYC SOX2
11 cell cycle arrest GO:0007050 9.56 CDKN1C MYC SOX2 TP53
12 growth hormone receptor signaling pathway GO:0060396 9.54 CSH1 CSH2
13 positive regulation of growth GO:0045927 9.52 CSH1 CSH2
14 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.48 LIN28A TP53
15 cellular response to cycloheximide GO:0071409 9.32 KLF4 MYC
16 endodermal cell fate specification GO:0001714 9.13 NANOG POU5F1 SOX2
17 somatic stem cell population maintenance GO:0035019 9.02 KLF4 LIN28A NANOG POU5F1 SOX2
18 regulation of transcription, DNA-templated GO:0006355 10.01 LIN28A MNX1 MYC NANOG POU5F1 SOX2

Molecular functions related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.97 KLF4 LIN28A MNX1 MYC NANOG POU5F1
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.86 KLF4 MNX1 MYC NANOG POU5F1 SOX2
3 transcription regulatory region DNA binding GO:0044212 9.71 KLF4 NANOG SOX2 TP53
4 sequence-specific DNA binding GO:0043565 9.5 KLF4 MNX1 MYC NANOG POU5F1 SOX2
5 growth hormone receptor binding GO:0005131 9.37 CSH1 CSH2
6 miRNA binding GO:0035198 9.33 LIN28A POU5F1 SOX2
7 DNA-binding transcription factor activity GO:0003700 9.23 KLF4 MNX1 MYC NANOG POU5F1 SOX2

Sources for Germ Cell and Embryonal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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