MCID: GRM001
MIFTS: 27

Germ Cell and Embryonal Cancer

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Germ Cell and Embryonal Cancer

MalaCards integrated aliases for Germ Cell and Embryonal Cancer:

Name: Germ Cell and Embryonal Cancer 12 15
Neoplasms, Germ Cell and Embryonal 44
Germ Cell and Embryonal Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3095
MeSH 44 D009373
UMLS 73 C0027658

Summaries for Germ Cell and Embryonal Cancer

Disease Ontology : 12 A germ cell cancer that is derives from a mixture of germs cells and embryonal cells.

MalaCards based summary : Germ Cell and Embryonal Cancer, also known as neoplasms, germ cell and embryonal, is related to teratoma and trophoblastic neoplasm. An important gene associated with Germ Cell and Embryonal Cancer is POU5F1 (POU Class 5 Homeobox 1), and among its related pathways/superpathways are Wnt Signaling Pathway and Pluripotency and Mesodermal Commitment Pathway. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Germ Cell and Embryonal Cancer

Diseases related to Germ Cell and Embryonal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 teratoma 31.8 AFP KRT7 MNX1 POU5F1 SOX2
2 trophoblastic neoplasm 31.8 CDKN1C CSH1 KHDC3L NLRP7 PAM
3 brain germinoma 10.9 AFP POU5F1
4 partial hydatidiform mole 10.9 KHDC3L NLRP7
5 extragonadal germ cell cancer 10.9 AFP POU5F1
6 sacrococcygeal teratoma 10.9 AFP MNX1
7 central nervous system germ cell tumor 10.8 AFP POU5F1 SOX2
8 embryonal testis carcinoma 10.8 AFP POU5F1
9 intrahepatic bile duct adenoma 10.8 AFP KRT7
10 childhood endodermal sinus tumor 10.8 AFP LIN28A
11 mature teratoma 10.8 AFP ANO6 POU5F1
12 hepatic angiomyolipoma 10.8 AFP MYC
13 triploidy 10.8 AFP KHDC3L NLRP7
14 malignant teratoma 10.7 AFP POU5F1 TG
15 renal pelvis adenocarcinoma 10.7 AFP KRT7
16 gallbladder signet ring cell adenocarcinoma 10.7 KRT7 MYC
17 intratubular embryonal carcinoma 10.6 AFP KRT7 POU5F1
18 testicular trophoblastic tumor 10.6 CSH1 CSH2
19 hydatidiform mole, recurrent, 1 10.6 CDKN1C KHDC3L NLRP7
20 ocular cancer 10.6 MYC POU5F1 SOX2
21 omphalocele 10.6 AFP CDKN1C MNX1
22 epithelioid trophoblastic tumor 10.6 CSH1 KRT7
23 bile duct cystadenocarcinoma 10.6 AFP KRT7
24 ovarian germ cell teratoma 10.6 KRT7 TG
25 malignant struma ovarii 10.5 AFP TG
26 malignant leydig cell tumor 10.5 KRT7 POU5F1
27 lung acinar adenocarcinoma 10.5 KRT7 MYC
28 sex cord-gonadal stromal tumor 10.5 AFP ANO6 KRT7
29 choriocarcinoma of ovary 10.5 CSH1 CSH2
30 ovarian germ cell cancer 10.5 AFP KRT7 TG
31 cystadenofibroma 10.5 AFP KRT7 TG
32 testicular granulosa cell tumor 10.5 AFP CSH1 CSH2
33 juvenile type testicular granulosa cell tumor 10.5 AFP CSH1 CSH2
34 liver lymphoma 10.4 AFP FUT4
35 rh isoimmunization 10.4 AFP CSH1 CSH2
36 hepatoblastoma 10.4 AFP CDKN1C KRT7
37 uterine anomalies 10.4 AFP CSH1 CSH2
38 sternum cancer 10.4 AFP FUT4
39 placenta disease 10.4 AFP CSH1 CSH2
40 adenomatoid tumor 10.4 AFP KRT7
41 gastrointestinal system cancer 10.4 AFP KRT7 MYC
42 ovarian embryonal carcinoma 10.4 AFP NANOG POU5F1 SOX2
43 extragonadal seminoma 10.3 AFP NANOG POU5F1 SOX2
44 embryonal carcinoma 10.3 AFP POU5F1 SOX2
45 testicular infarct 10.3 AFP FUT4 POU5F1
46 mixed germ cell cancer 10.3 AFP FUT4 POU5F1
47 non-gestational choriocarcinoma 10.3 CSH1 CSH2
48 seminal vesicle tumor 10.2 AFP KRT7
49 cell type cancer 10.1 AFP KRT7 MYC POU5F1 SOX2
50 choriocarcinoma of the testis 10.1 AFP CSH1 CSH2 KRT7

Graphical network of the top 20 diseases related to Germ Cell and Embryonal Cancer:



Diseases related to Germ Cell and Embryonal Cancer

Symptoms & Phenotypes for Germ Cell and Embryonal Cancer

GenomeRNAi Phenotypes related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.47 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.47 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.47 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.47 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.47 KRT7
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.47 POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.47 KRT7 POU5F1 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.47 AFP
9 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.47 POU5F1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.47 POU5F1 KRT7

MGI Mouse Phenotypes related to Germ Cell and Embryonal Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.23 SOX2 AFP DIO3 KHDC3L KLF4 LIN28A

Drugs & Therapeutics for Germ Cell and Embryonal Cancer

Search Clinical Trials , NIH Clinical Center for Germ Cell and Embryonal Cancer

Cochrane evidence based reviews: neoplasms, germ cell and embryonal

Genetic Tests for Germ Cell and Embryonal Cancer

Anatomical Context for Germ Cell and Embryonal Cancer

Publications for Germ Cell and Embryonal Cancer

Variations for Germ Cell and Embryonal Cancer

Expression for Germ Cell and Embryonal Cancer

Search GEO for disease gene expression data for Germ Cell and Embryonal Cancer.

Pathways for Germ Cell and Embryonal Cancer

GO Terms for Germ Cell and Embryonal Cancer

Biological processes related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.88 KLF4 MYC NANOG POU5F1 SOX2
2 response to wounding GO:0009611 9.58 MYC POU5F1 SOX2
3 regulation of gene expression GO:0010468 9.55 MYC NANOG NLRP7 POU5F1 SOX2
4 stem cell population maintenance GO:0019827 9.5 KLF4 LIN28A NANOG
5 response to growth factor GO:0070848 9.46 MYC SOX2
6 hormone biosynthetic process GO:0042446 9.43 DIO3 TG
7 thyroid hormone metabolic process GO:0042403 9.37 DIO3 TG
8 cellular response to cycloheximide GO:0071409 9.26 KLF4 MYC
9 endodermal cell fate specification GO:0001714 9.13 NANOG POU5F1 SOX2
10 somatic stem cell population maintenance GO:0035019 9.02 KLF4 LIN28A NANOG POU5F1 SOX2

Molecular functions related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.43 KLF4 MNX1 MYC NANOG POU5F1 SOX2
2 hormone activity GO:0005179 9.33 CSH1 CSH2 TG
3 miRNA binding GO:0035198 8.8 LIN28A POU5F1 SOX2

Sources for Germ Cell and Embryonal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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