MCID: GRM001
MIFTS: 25

Germ Cell and Embryonal Cancer

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Germ Cell and Embryonal Cancer

MalaCards integrated aliases for Germ Cell and Embryonal Cancer:

Name: Germ Cell and Embryonal Cancer 12 15
Germ Cell and Embryonal Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3095
MeSH 44 D009373
UMLS 70 C0027658

Summaries for Germ Cell and Embryonal Cancer

Disease Ontology : 12 A germ cell cancer that is derives from a mixture of germs cells and embryonal cells.

MalaCards based summary : Germ Cell and Embryonal Cancer, also known as germ cell and embryonal neoplasm, is related to teratoma and trophoblastic neoplasm. An important gene associated with Germ Cell and Embryonal Cancer is MIR371A (MicroRNA 371a), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Human Embryonic Stem Cell Pluripotency. Related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Germ Cell and Embryonal Cancer

Diseases related to Germ Cell and Embryonal Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 teratoma 32.6 SOX2 POU5F1 NES AFP
2 trophoblastic neoplasm 11.3
3 pediatric testicular germ cell tumor 10.5 POU5F1 AFP
4 ovarian embryonal carcinoma 10.5 POU5F1 AFP
5 childhood endodermal sinus tumor 10.5 MIR371A MIR302A AFP
6 dysgerminoma 10.5 MIR371A MIR302C AFP
7 mixed germ cell cancer 10.5 MIR371A MIR302A AFP
8 central nervous system immature teratoma 10.5 SOX2 NES
9 central nervous system germinoma 10.5 POU5F1 MIR302C MIR302A
10 ovarian primitive germ cell tumor 10.5 POU5F1 AFP
11 ovarian endodermal sinus tumor 10.5 POU5F1 AFP
12 intratubular embryonal carcinoma 10.5 POU5F1 AFP
13 spermatogenic failure, y-linked, 1 10.5 POU5F1 MYC KLF4
14 parkinson disease 17 10.5 SOX2 POU5F1 NANOG
15 epilepsy, idiopathic generalized 15 10.5 SOX2 MYC KLF4
16 mixed cell type cancer 10.5 LCOR H2AC18 AFP
17 germinoma 10.5 POU5F1 MIR371A MIR302A AFP
18 dysgerminoma of ovary 10.5 POU5F1 NANOG MIR371A AFP
19 central nervous system primitive neuroectodermal neoplasm 10.5 NES MIR371A LIN28A
20 testicular germ cell tumor 10.5 MIR373 MIR371A AFP
21 ependymoblastoma 10.5 NES MIR371A LIN28A
22 macular degeneration, age-related, 7 10.5 SOX2 POU5F1 NANOG KLF4
23 spermatocytoma 10.5 POU5F1 NANOG MIR371A AFP
24 central nervous system benign neoplasm 10.5 LCOR KDM4C H2AC18
25 pediatric germ cell cancer 10.5 MIR371A MIR302C MIR302A AFP
26 testicular germ cell cancer 10.5 MIR373 MIR371A AFP
27 mediastinal malignant lymphoma 10.5 KDM4C FUT4
28 hepatic angiomyolipoma 10.5 MYC AFP
29 endodermal sinus tumor 10.5 MIR371A MIR302C MIR302A AFP
30 bone osteosarcoma 10.5 MYC LCOR H2AC18
31 pre-malignant neoplasm 10.5 MYC LCOR H2AC18
32 colonic benign neoplasm 10.5 MYC KDM4C H2AC18
33 tyrosinemia 10.5 SOX2 POU5F1 NANOG AFP
34 central nervous system hematologic cancer 10.5 MYC LCOR KDM4C
35 in situ carcinoma 10.5 MYC LCOR H2AC18
36 placenta disease 10.5 MIR371A H2AC18 AFP
37 ovarian germ cell teratoma 10.5 MIR302C AFP
38 inflammatory bowel disease 28 10.5 SOX2 POU5F1 MYC KLF4
39 hodgkin's lymphoma, nodular sclerosis 10.5 KDM4C FUT4
40 mature t-cell and nk-cell lymphoma 10.5 MYC KDM4C H2AC18
41 non-gestational choriocarcinoma 10.5 MIR302C AFP
42 mediastinal gray zone lymphoma 10.5 KDM4C FUT4
43 rhabdoid cancer 10.5 MYC KDM4C H2AC18
44 dysembryoplastic neuroepithelial tumor 10.5 NES LCOR KDM4C
45 medulloepithelioma 10.5 NES LIN28A FGF2
46 juvenile type testicular granulosa cell tumor 10.4 MIR302C AFP
47 lymphangioma 10.4 MYC KDM4C H2AC18
48 central nervous system germ cell tumor 10.4 POU5F1 AFP
49 teratocarcinoma 10.4 POU5F1 NANOG MIR302A FGF2
50 testicular granulosa cell tumor 10.4 MIR302C AFP

Graphical network of the top 20 diseases related to Germ Cell and Embryonal Cancer:



Diseases related to Germ Cell and Embryonal Cancer

Symptoms & Phenotypes for Germ Cell and Embryonal Cancer

MGI Mouse Phenotypes related to Germ Cell and Embryonal Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 FGF2 FUT4 KDM4C KLF4 LIF LIN28A
2 endocrine/exocrine gland MP:0005379 9.28 AFP KDM4C KLF4 LIF LIN28A MYC

Drugs & Therapeutics for Germ Cell and Embryonal Cancer

Search Clinical Trials , NIH Clinical Center for Germ Cell and Embryonal Cancer

Genetic Tests for Germ Cell and Embryonal Cancer

Anatomical Context for Germ Cell and Embryonal Cancer

Publications for Germ Cell and Embryonal Cancer

Variations for Germ Cell and Embryonal Cancer

Expression for Germ Cell and Embryonal Cancer

Search GEO for disease gene expression data for Germ Cell and Embryonal Cancer.

Pathways for Germ Cell and Embryonal Cancer

Pathways related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.43 SOX2 SOX17 POU5F1 NANOG MIR373 MIR302C
2
Show member pathways
12.28 SOX2 POU5F1 NANOG FGF2
3 12.13 SOX2 POU5F1 NANOG LIN28A KLF4 FUT4
4
Show member pathways
12.06 SOX2 POU5F1 NANOG MYC
5 11.96 SOX2 POU5F1 NANOG MYC LIF KLF4
6 11.89 SOX2 NANOG MYC LIF FGF2
7 11.6 SOX2 NES FGF2
8 11.54 SOX2 POU5F1 NANOG MIR302A KLF4
9 11.49 SOX2 SOX17 POU5F1 NES NANOG MYC
10 11.37 MYC MIR373 MIR371A
11 11.36 SOX2 SOX17 POU5F1 NANOG LIN28A FGF2
12
Show member pathways
11.12 SOX2 POU5F1 NANOG LIN28A KLF4 FGF2
13 10.88 SOX2 POU5F1 NANOG
14
Show member pathways
10.63 SOX2 POU5F1 NANOG

GO Terms for Germ Cell and Embryonal Cancer

Cellular components related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 9.26 SOX2 SOX17 POU5F1 KLF4
2 chromatin GO:0000785 9.23 SOX2 SOX17 POU5F1 NANOG MYC KLF4

Biological processes related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.97 SOX2 POU5F1 NANOG MYC LCOR KLF4
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 SOX2 SOX17 POU5F1 NANOG MYC LIF
3 gene silencing by miRNA GO:0035195 9.91 MIR373 MIR371A MIR369 MIR302C MIR302A
4 positive regulation of gene expression GO:0010628 9.87 SOX17 POU5F1 MYC LIF KLF4 KDM4C
5 cytokine-mediated signaling pathway GO:0019221 9.83 SOX2 NANOG MYC LIF FGF2
6 stem cell differentiation GO:0048863 9.58 SOX17 LIN28A LIF
7 regulation of cell differentiation GO:0045595 9.56 SOX17 NANOG LIF KLF4
8 response to growth factor GO:0070848 9.54 SOX2 MYC
9 positive regulation of DNA biosynthetic process GO:2000573 9.52 MYC FGF2
10 stem cell proliferation GO:0072089 9.48 NES FGF2
11 cardiac cell fate determination GO:0060913 9.46 SOX17 POU5F1
12 stem cell population maintenance GO:0019827 9.46 NANOG LIN28A LIF KLF4
13 somatic stem cell population maintenance GO:0035019 9.43 SOX2 POU5F1 NANOG LIN28A KLF4 FGF2
14 endodermal cell fate specification GO:0001714 8.92 SOX2 SOX17 POU5F1 NANOG

Molecular functions related to Germ Cell and Embryonal Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.63 SOX2 SOX17 POU5F1 NANOG MYC KLF4
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.56 MIR373 MIR371A MIR302C MIR302A
3 miRNA binding GO:0035198 9.13 SOX2 POU5F1 LIN28A
4 transcription regulatory region sequence-specific DNA binding GO:0000976 9.02 SOX2 SOX17 POU5F1 NANOG KLF4

Sources for Germ Cell and Embryonal Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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