MCID: GRM005
MIFTS: 52

Germ Cell Cancer

Categories: Cancer diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Germ Cell Cancer

MalaCards integrated aliases for Germ Cell Cancer:

Name: Germ Cell Cancer 12 55 15
Neoplasms, Germ Cell and Embryonal 44
Malignant Tumor of the Germ Cell 12
Malignant Germ Cell Tumor 53
Germ Cell Neoplasm 12
Germ Cell Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2994
MeSH 44 D009373
NCIt 50 C3708
SNOMED-CT 68 28307001
UMLS 73 C0205851

Summaries for Germ Cell Cancer

Disease Ontology : 12 A cell type cancer that has material basis in abnormally proliferating cells derives from germ cells.

MalaCards based summary : Germ Cell Cancer, also known as neoplasms, germ cell and embryonal, is related to extragonadal germ cell cancer and testicular germ cell cancer. An important gene associated with Germ Cell Cancer is H19 (H19, Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Gastric cancer and Pathways in cancer. The drugs Paclitaxel and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and bone marrow, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Related Diseases for Germ Cell Cancer

Diseases related to Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 extragonadal germ cell cancer 34.3 AFP POU5F1
2 testicular germ cell cancer 33.9 ALPP AR DMRT1 ESR2 KITLG
3 testicular malignant germ cell cancer 33.8 AFP ALPP
4 ovarian mixed germ cell neoplasm 33.8 AFP CGA
5 testicular cancer 30.8 AFP ALPP AR CGA
6 seminoma 30.6 AFP ALPG ALPP CGA ESR2 POU5F1
7 teratoma 30.4 AFP CGA DMRT1 POU5F1
8 testicular seminoma 30.4 AFP CGA
9 choriocarcinoma 30.1 ALPG ALPP CGA H19
10 intratubular embryonal carcinoma 30.1 AFP POU5F1
11 cryptorchidism, unilateral or bilateral 30.0 ALPG AR CGA
12 malignant teratoma 30.0 AFP POU5F1
13 embryonal carcinoma 29.6 AFP FGF4 H19 IGF2 POU5F1 TUBB3
14 ovarian germ cell cancer 12.6
15 mixed germ cell cancer 12.4
16 mixed extragonadal germ cell cancer 12.4
17 pediatric germ cell cancer 12.4
18 retroperitoneal germ cell neoplasm 12.3
19 malignant pineal area germ cell neoplasm 12.2
20 malignant childhood germ cell neoplasm 12.2
21 fallopian tube germ cell cancer 12.2
22 malignant germ cell tumor of the cervix uteri 11.3
23 malignant cardiac germ cell tumor 11.3
24 malignant non-dysgerminomatous germ cell tumor of ovary 11.2
25 malignant germ cell tumor of the vagina 11.2
26 malignant germ cell tumor of the corpus uteri 11.2
27 malignant dysgerminomatous germ cell tumor of the ovary 11.2
28 vaginal yolk sac tumor 11.2
29 central nervous system childhood germ cell tumor 11.2
30 pediatric testicular germ cell tumor 11.2
31 childhood testicular mixed germ cell tumor 11.2
32 childhood germ cell brain tumor 11.2
33 ovarian primitive germ cell tumor 11.1
34 choriocarcinoma of ovary 11.1
35 immature teratoma of ovary 11.1
36 endodermal sinus tumor 11.0
37 germ cell and embryonal cancer 11.0
38 dysgerminoma 11.0
39 fallopian tube teratoma 11.0
40 extragonadal nonseminomatous germ cell tumor 11.0
41 pediatric ovarian germ cell tumor 11.0
42 polyembryoma 10.3 AFP CGA
43 sacrococcygeal teratoma 10.3 AFP CGA
44 mixed germ cell tumor 10.3 AFP CGA
45 central nervous system germinoma 10.3 ALPP POU5F1
46 triploidy 10.3 AFP CGA
47 brain germinoma 10.3 AFP POU5F1
48 trigonitis 10.3 CSF3 ESR1
49 leydig cell hypoplasia 10.3 CGA LHCGR
50 oncocytic breast carcinoma 10.3 AR ESR1

Graphical network of the top 20 diseases related to Germ Cell Cancer:



Diseases related to Germ Cell Cancer

Symptoms & Phenotypes for Germ Cell Cancer

MGI Mouse Phenotypes related to Germ Cell Cancer:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.24 AFP AR CGA DMRT1 ESR1 ESR2
2 growth/size/body region MP:0005378 10.22 ALPG AR CGA ESR1 ESR2 FGF4
3 mortality/aging MP:0010768 10.18 AFP ALPG AR ESR1 ESR2 FGF4
4 digestive/alimentary MP:0005381 10.11 AR ESR1 ESR2 IGF2 KITLG LHCGR
5 limbs/digits/tail MP:0005371 10.06 AR ESR1 ESR2 FGF4 IGF2 KITLG
6 nervous system MP:0003631 10.06 AR CGA ESR1 ESR2 IGF2 KITLG
7 liver/biliary system MP:0005370 10.03 AFP AR ESR1 ESR2 IGF2 KITLG
8 reproductive system MP:0005389 9.97 AFP ALPG AR CGA DMRT1 ESR1
9 normal MP:0002873 9.86 ALPG AR ESR1 ESR2 FGF4 LHCGR
10 neoplasm MP:0002006 9.85 AFP AR ESR1 ESR2 KITLG TERT
11 respiratory system MP:0005388 9.56 ESR1 ESR2 FGF4 IGF2 LHCGR SPRY4
12 skeleton MP:0005390 9.28 AR ESR1 ESR2 FGF4 IGF2 KITLG

Drugs & Therapeutics for Germ Cell Cancer

Drugs for Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
2
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
3
Bleomycin Approved, Investigational Phase 2, Phase 3,Phase 3 11056-06-7 5360373
4
Etoposide Approved Phase 2, Phase 3,Phase 3,Phase 1 33419-42-0 36462
5
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 2767 441203 84093
6
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
7
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
8
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
9 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
10 Etoposide phosphate Phase 2, Phase 3,Phase 3,Phase 1
11 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
12 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3
13 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3,Phase 1
14 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
15 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
16
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
17 Alkylating Agents Phase 3,Phase 1,Phase 2
18 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
19 Liver Extracts Phase 3
20
Dexamethasone Approved, Investigational, Vet_approved Phase 1, Phase 2 50-02-2 5743
21
Mannitol Approved, Investigational Phase 1, Phase 2 69-65-8 453 6251
22
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1, Phase 2 1177-87-3
23
Gemcitabine Approved Phase 1, Phase 2,Phase 2 95058-81-4 60750
24
Mesna Approved, Investigational Phase 1, Phase 2 3375-50-6 598
25
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9 24083
26
Furosemide Approved, Vet_approved Phase 1, Phase 2 54-31-9 3440
27
Ranitidine Approved Phase 1, Phase 2 66357-35-5, 66357-59-3 3001055
28
Nicotinamide Approved, Investigational Phase 2 98-92-0 936
29
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
30
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
31
Everolimus Approved Phase 2 159351-69-6 6442177
32
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
33
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
34
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
35
Arsenic trioxide Approved, Investigational Phase 2 1327-53-3 518740
36
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
37
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 6857599 5310940 9887054
38
Bevacizumab Approved, Investigational Phase 2 216974-75-3
39
Thiotepa Approved, Investigational Phase 1, Phase 2 52-24-4 5453
40
Olaparib Approved Phase 2 763113-22-0 23725625
41
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
43
Veliparib Investigational Phase 2 912444-00-9 11960529
44 Adjuvants, Immunologic Phase 1, Phase 2
45 Immunologic Factors Phase 1, Phase 2,Phase 2
46 Antimetabolites, Antineoplastic Phase 1, Phase 2,Phase 2
47 Antiviral Agents Phase 1, Phase 2,Phase 2
48 Ranitidine bismuth citrate Phase 1, Phase 2
49 Anti-Infective Agents Phase 1, Phase 2,Phase 2
50
Chlorpheniramine Phase 1, Phase 2 113-92-8, 132-22-9 2725

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
3 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
4 Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles Completed NCT00324298 Phase 3 cisplatin;etoposide
5 TC or BEP in Treating Patients With Malignant Ovarian Germ Cell Tumors Recruiting NCT02429687 Phase 3 Paclitaxel;Carboplatin;Bleomycin;Etoposide;Cisplatin
6 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
7 Sorafenib Monotherapy in Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy Unknown status NCT00772694 Phase 2 sorafenib
8 Phase-II Study of SU011248 (Sunitinib)in Male Patients With Relapsed or Cisplatin-Refractory Germ Cell Cancer Completed NCT00371553 Phase 2 SU011248 (Sunitinib)
9 Everolimus in Refractory Testicular Germ Cell Cancer Completed NCT01466231 Phase 2 Everolimus
10 Everolimus for Patients With Relapsed/Refractory Germ Cell Cancer Completed NCT01242631 Phase 2 Everolimus
11 Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer Completed NCT00002903 Phase 2 docetaxel
12 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
13 Arsenic Trioxide in Treating Men With Germ Cell Cancer Completed NCT00036842 Phase 2 arsenic trioxide
14 Brentuximab Vedotin (SGN-35) as Salvage Treatment for CD30-positive Germ Cell Tumors Completed NCT01851200 Phase 2 Brentuximab Vedotin
15 Carboplatin, Etoposide, Cyclophosphamide, and Autologous Bone Marrow Transplantation in Patients With Relapsed or Refractory Cancer Completed NCT00002943 Phase 2 carboplatin;cyclophosphamide;etoposide
16 Phase II Study of Oxaliplatine-Paclitaxel in Patients With Metastatic Germ Cell Tumor Refractory to Cisplatin Completed NCT00611962 Phase 2 Oxaliplatin, Paclitaxel
17 Study of Oxaliplatin Plus Bevacizumab in Germ Cell Tumor Patients Completed NCT00393861 Phase 2 Bevacizumab and Oxaliplatin
18 Combination Chemotherapy Followed by Bone Marrow or Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00002508 Phase 1, Phase 2 carboplatin;etoposide
19 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors Completed NCT00002558 Phase 1, Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
20 Sunitinib® in Patients With Recurrent Ovarian Clear Cell Carcinoma Completed NCT01824615 Phase 2 Sunitinib
21 Effectiveness of an Individualized Program of Muscular Strength and Endurance Program for Improving Germ Cell Cancer Recruiting NCT02433197 Phase 1, Phase 2
22 Avelumab in Refractory Testicular Germ Cell Cancer. Recruiting NCT03403777 Phase 2 Avelumab
23 Study of Gemcitabine, Carboplatin and VELIPARIB (ABT-888) in Refractory Testicular Germ Cell Cancer Recruiting NCT02860819 Phase 2 Veliparib;Gemcitabine;Carboplatin
24 Testis CAB: Cabazitaxel as Salvage Treatment for Cisplatin-resistant Germ Cell Cancer Recruiting NCT02478502 Phase 2 cabazitaxel
25 First Line TIP in Poor Prognosis TGCTs. Recruiting NCT02414685 Phase 2 Paclitaxel;Ifosfamide;Cisplatin
26 Role of Axumin PET Scan in Germ Cell Tumor Recruiting NCT03426865 Phase 2 Axumin PET scan
27 Low-Dose CT - Stage I Testicular Cancer Active, not recruiting NCT03142802 Phase 2
28 Olaparib as Salvage Treatment for Cisplatin-resistant Germ Cell Tumor Active, not recruiting NCT02533765 Phase 2 Olaparib
29 Trial of Paclitaxel, Gemcitabine and Cisplatin in Patients With Relapsing Germ Cell Cancer Terminated NCT00531687 Phase 2 Paclitaxel;Cisplatin;Gemcitabine
30 Genetics of Familial Testicular Cancer Completed NCT00342537
31 A Case-Control Study of Testicular Germ Cell Tumors Among U.S. Military Servicemen Completed NCT00341588
32 Toxicity Attributed to Genetic Polymorphisms in Testicular Germ Cell Tumor Survivors Recruiting NCT02303015
33 Clinical Characterisation of the Vascular Effects of Cis-platinum Based Chemotherapy in Patients With Testicular Cancer Recruiting NCT03557177
34 Swiss Austrian German Testicular Cancer Cohort Study - SAG TCCS Recruiting NCT02229916
35 Acute Changes in Endothelial Function in Germ Cell Tumor Patients Treated With Cisplatin and Untreated Germ Cell Tumor Controls Active, not recruiting NCT01453660
36 Genomic Structural Variation in Cancer Susceptibility Enrolling by invitation NCT00996710
37 Multicenter Database of Patients With Germ Cell Tumor Not yet recruiting NCT02863003
38 Quality-of-Life Study of Patients With Previously Treated Ovarian Cancer Terminated NCT00003794

Search NIH Clinical Center for Germ Cell Cancer

Cochrane evidence based reviews: neoplasms, germ cell and embryonal

Genetic Tests for Germ Cell Cancer

Anatomical Context for Germ Cell Cancer

MalaCards organs/tissues related to Germ Cell Cancer:

41
Testis, Bone, Bone Marrow, Liver, Brain, Lymph Node, Prostate

Publications for Germ Cell Cancer

Articles related to Germ Cell Cancer:

(show top 50) (show all 397)
# Title Authors Year
1
Complex Polygenic Nature of Testicular Germ Cell Cancer Suggests Multifactorial Aetiology. ( 29530636 )
2018
2
A Risk-Adapted Approach to Patients with Stage I Seminoma according to the Status of Rete Testis: The Fourth Spanish Germ Cell Cancer Group Study. ( 29587278 )
2018
3
Is the FSHR 2039A>G variant associated with susceptibility to testicular germ cell cancer? ( 29179257 )
2018
4
Improved survival in metastatic germ-cell cancer. ( 29161363 )
2018
5
Long-term toxicity of the treatment for germ cell-cancer. A review. ( 29279100 )
2018
6
Therapeutic approaches for refractory germ cell cancer. ( 29516750 )
2018
7
High β-1,4-Galactosyltransferase-I expression in peripheral T-lymphocytes is associated with a low risk of relapse in germ-cell cancer patients receiving high-dose chemotherapy with autologous stem cell reinfusion. ( 29721375 )
2018
8
Testis-Sparing Surgery in Patients with Germ Cell Cancer: Indications and Clinical Outcome. ( 29763922 )
2018
9
Biological basis and early clinical results of immunotherapy for cisplatin-resistant germ cell cancer. ( 29957683 )
2018
10
Risk of Solid Cancer After Treatment of Testicular Germ Cell Cancer in the Platinum Era. ( 29989856 )
2018
11
ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up. ( 30113631 )
2018
12
Salvage Chemotherapy With Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin for Relapsed Germ Cell Cancer. ( 30115544 )
2018
13
Management of Refractory Germ Cell Cancer. ( 30231348 )
2018
14
Questioning the Value of Fluorodeoxyglucose Positron Emission Tomography for Residual Lesions After Chemotherapy for Metastatic Seminoma: Results of an International Global Germ Cell Cancer Group Registry. ( 30285559 )
2018
15
Palliative treatment of germ cell cancer. ( 30415106 )
2018
16
microRNA-371a-3p as informative biomarker for the follow-up of testicular germ cell cancer patients. ( 28612337 )
2017
17
Cisplatin-related Cerebral Infarction in Testicular Germ Cell Cancer: Short Report of Three Cases and P in testicular germ cell cancer: Short report of three cases and pathomechanism. ( 27923208 )
2017
18
Long-term ototoxicity in women after cisplatin treatment for ovarian germ cell cancer. ( 28202195 )
2017
19
Risk of low bone mineral density in testicular germ cell cancer survivors: association with hypogonadism and treatment modality. ( 28591464 )
2017
20
Animacroxam, a novel dual-mode compound targeting histone deacetylases and cytoskeletal integrity of testicular germ cell cancer cells. ( 28838999 )
2017
21
Prognostic Factors and Treatment Results After Bleomycin, Etoposide, and Cisplatin in Germ Cell Cancer: A Population-based Study. ( 27649970 )
2017
22
High-dose chemotherapy as salvage treatment in germ-cell cancer: when, in whom and how. ( 27678272 )
2017
23
Prognostic Significance of Venous Thromboembolic Events in Disseminated Germ Cell Cancer Patients. ( 28122896 )
2017
24
Response to anti-programmed cell death protein-1 antibodies in men treated for platinum refractory germ cell cancer relapsed after high-dose chemotherapy and stem cell transplantation. ( 28262583 )
2017
25
Retinal toxicity after cisplatin-based chemotherapy in patients with germ cell cancer. ( 28281024 )
2017
26
Efficacy of targeted drugs in germ cell cancer cell lines with differential cisplatin sensitivity. ( 28591197 )
2017
27
Consensus Recommendations from the Spanish Germ Cell Cancer Group on the Use of High-dose Chemotherapy in Germ Cell Cancer. ( 28753776 )
2017
28
Age ≥40 Years Is Associated with Adverse Outcome in Metastatic Germ Cell Cancer Despite Appropriate Intended Chemotherapy. ( 28753801 )
2017
29
No longer any role for routine follow-up chest x-rays in men with stage I germ cell cancer. ( 28866371 )
2017
30
Accurate primary germ cell cancer diagnosis using serum based microRNA detection (ampTSmiR test). ( 28938535 )
2017
31
Re: Second Malignant Neoplasms and Cause of Death in Patients with Germ Cell Cancer: A Danish Nationwide Cohort Study. ( 29059778 )
2017
32
A Brief Review of the Link between Environment and Male Reproductive Health: Lessons from Studies of Testicular Germ Cell Cancer. ( 26871895 )
2016
33
Effectiveness of an individualized program of muscular strength and endurance with aerobic training for improving germ cell cancer-related fatigue in men undergoing chemotherapy: EFICATEST study protocol for a randomized controlled trial. ( 26732120 )
2016
34
Pulmonary Function in Patients With Germ Cell Cancer Treated With Bleomycin, Etoposide, and Cisplatin. ( 26903578 )
2016
35
High Rates of Thromboembolic Events in Patients with Germ Cell Cancer Undergoing Cisplatin-Based Polychemotherapy. ( 27074038 )
2016
36
Efficacy and safety of gemcitabine, oxaliplatin, and paclitaxel in cisplatin-refractory germ cell cancer in routine care-Registry data from an outcomes research project of the German Testicular Cancer Study Group. ( 26699830 )
2016
37
Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review. ( 27821802 )
2016
38
Muscle satellite cell content and mRNA signaling in germ cell cancer patients - effects of chemotherapy and resistance training. ( 27218150 )
2016
39
Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment. ( 27873769 )
2016
40
Elucidating human male germ cell development by studying germ cell cancer. ( 27512122 )
2016
41
Second Malignant Neoplasms and Cause of Death in Patients With Germ Cell Cancer: A Danish Nationwide Cohort Study. ( 27711914 )
2016
42
The prognostic value of DNA damage level in peripheral blood lymphocytes of chemotherapy-naïve patients with germ cell cancer. ( 27732956 )
2016
43
Validation of a prediction model for avoiding post-chemotherapy retroperitoneal lymphadenectomy in patients with metastatic nonseminomatous germ cell cancer. ( 27878048 )
2016
44
Increasing international efforts to understand and conquer testicular germ cell cancer. ( 25711179 )
2015
45
Intensive chemotherapy as salvage treatment for solid tumors: focus on germ cell cancer. ( 25493378 )
2015
46
Re: First Salvage Treatment in Patients with Advanced Germ Cell Cancer after Cisplatin-Based Chemotherapy: Analysis of a Registry of the German Testicular Cancer Study Group (GTCSG). ( 25765390 )
2015
47
Germ Cell Cancer and Multiple Relapses: Toxicity and Survival. ( 26240225 )
2015
48
Involvement of epigenetic modifiers in the pathogenesis of testicular dysgenesis and germ cell cancer. ( 26103631 )
2015
49
Low RBM3 Protein Expression Correlates with Clinical Stage, Prognostic Classification and Increased Risk of Treatment Failure in Testicular Non-Seminomatous Germ Cell Cancer. ( 25811459 )
2015
50
Treatment-related cardiovascular late effects and exercise training countermeasures in testicular germ cell cancer survivorship. ( 25751759 )
2015

Variations for Germ Cell Cancer

Expression for Germ Cell Cancer

Search GEO for disease gene expression data for Germ Cell Cancer.

Pathways for Germ Cell Cancer

GO Terms for Germ Cell Cancer

Biological processes related to Germ Cell Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 AR CGA CSF3 FGF4 IGF2 KITLG
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.8 AR ATF7IP DMRT1 ESR1 ESR2 IGF2
3 regulation of signaling receptor activity GO:0010469 9.77 CGA CSF3 FGF4 IGF2 KITLG
4 positive regulation of transcription by RNA polymerase II GO:0045944 9.76 AR CGA CSF3 DMRT1 ESR1 FGF4
5 transcription, DNA-templated GO:0006351 9.71 AR ESR1 ESR2 POU5F1
6 phosphatidylinositol phosphorylation GO:0046854 9.67 ESR1 FGF4 KITLG
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.65 CSF3 ESR1 ESR2
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.61 CSF3 IGF2 KITLG
9 mammary gland alveolus development GO:0060749 9.46 AR ESR1
10 positive regulation of protein kinase B signaling GO:0051897 9.35 CSF3 ESR1 FGF4 IGF2 KITLG
11 male gonad development GO:0008584 9.02 AR DMRT1 ESR1 KITLG LHCGR

Molecular functions related to Germ Cell Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.89 AR DMRT1 ESR1 ESR2 POU5F1
2 growth factor activity GO:0008083 9.67 CSF3 FGF4 IGF2 KITLG
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.63 ESR1 FGF4 KITLG
4 steroid hormone receptor activity GO:0003707 9.58 AR ESR1 ESR2
5 transcription coactivator binding GO:0001223 9.48 ESR1 TERT
6 alkaline phosphatase activity GO:0004035 9.43 ALPG ALPP
7 nuclear receptor activity GO:0004879 9.43 AR ESR1 ESR2
8 estrogen receptor activity GO:0030284 9.32 ESR1 ESR2
9 estrogen response element binding GO:0034056 9.16 ESR1 ESR2
10 steroid binding GO:0005496 9.13 AR ESR1 ESR2
11 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.62 ESR1 ESR2

Sources for Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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