MCID: GRM005
MIFTS: 46

Germ Cell Cancer

Categories: Cancer diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Germ Cell Cancer

MalaCards integrated aliases for Germ Cell Cancer:

Name: Germ Cell Cancer 12 54 15 70
Malignant Germ Cell Tumor 20 17
Neoplasms, Germ Cell and Embryonal 44
Malignant Tumor of the Germ Cell 12
Malignant Germ Cell Neoplasm 70
Neoplasms Germ Cell 54
Germ Cell Neoplasm 12
Germ Cell Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2994
MeSH 44 D009373
NCIt 50 C3708
SNOMED-CT 67 302853003
UMLS 70 C0205851 C0740345 C4048549

Summaries for Germ Cell Cancer

Disease Ontology : 12 A cell type cancer that has material basis in abnormally proliferating cells derives from germ cells.

MalaCards based summary : Germ Cell Cancer, also known as malignant germ cell tumor, is related to extragonadal germ cell cancer and mixed germ cell cancer. An important gene associated with Germ Cell Cancer is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Pathways in cancer and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. The drugs Thiotepa and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include testis, bone and lymph node, and related phenotypes are endocrine/exocrine gland and liver/biliary system

Related Diseases for Germ Cell Cancer

Diseases related to Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 290)
# Related Disease Score Top Affiliating Genes
1 extragonadal germ cell cancer 33.1 ATF7IP AFP
2 mixed germ cell cancer 33.0 MIR371A AFP
3 pediatric germ cell cancer 33.0 SPRY4 MIR371A H19 DMRT1 AFP
4 pediatric testicular germ cell tumor 32.7 POU5F1 AFP
5 ovarian mixed germ cell neoplasm 32.7 CGA AFP
6 central nervous system germ cell tumor 32.6 POU5F1 AFP
7 ovarian primitive germ cell tumor 32.4 POU5F1 AFP
8 endodermal sinus tumor 32.4 MIR371A ALPP ALPG AFP
9 dysgerminoma 32.4 MIR371A KITLG ALPP ALPG AFP
10 testicular germ cell cancer 32.3 TERT SPRY4 MIR373 MIR372 MIR371A MIR367
11 germinoma 32.3 POU5F1 MIR371A CGA ALPP AFP
12 germ cell and embryonal cancer 32.2 POU5F1 MIR373 MIR371A FGF4 AFP
13 testicular cancer 31.7 TERT SPRY4 KITLG FGF4 DMRT1 CGA
14 seminoma 31.7 POU5F1 IGF2 ESR2 DMRT1 CGA ALPP
15 teratoma 31.6 POU5F1 DMRT1 CGA AFP
16 mature teratoma 31.4 POU5F1 MIR371A AFP
17 embryonal carcinoma 31.2 POU5F1 IGF2 H19 FGF4 ALPG AFP
18 testicular germ cell tumor 31.0 SPRY4 MIR373 MIR372 MIR371A MIR367 KITLG
19 gonadoblastoma 30.9 POU5F1 DMRT1 ALPP ALPG
20 cryptorchidism, unilateral or bilateral 30.9 SPRY4 POU5F1 KITLG ESR2 DMRT1 CGA
21 choriocarcinoma 30.8 IGF2 H19 CGA ALPP ALPG
22 polyembryoma 30.8 CGA AFP
23 androgen insensitivity syndrome 30.7 IGF2 CGA AR ALPG
24 ovarian gonadoblastoma 30.7 POU5F1 DMRT1 AFP
25 mediastinum seminoma 30.6 ALPP AFP
26 sertoli cell tumor 30.6 AR ALPP AFP
27 testicular disease 30.6 SPRY4 POU5F1 MIR371A KITLG DMRT1 AR
28 mixed germ cell tumor 30.6 CGA AFP
29 brain germinoma 30.6 SPRY4 POU5F1 AFP
30 central nervous system germinoma 30.6 POU5F1 ALPP
31 spermatocytoma 30.5 POU5F1 MIR371A DMRT1 AFP
32 malignant teratoma 30.5 POU5F1 MIR371A AFP
33 disorder of sexual development 30.5 DMRT1 AR AFP
34 leukemia, acute myeloid 30.5 TERT POU5F1 MIR372 MIR367 KITLG CSF3
35 trophoblastic neoplasm 30.5 MIR371A H19 CGA AFP
36 gestational trophoblastic neoplasm 30.5 IGF2 H19 AFP
37 esophageal cancer 30.1 TERT MIR373 IGF2 H19 FGF4 AR
38 ovarian germ cell cancer 11.5
39 mixed extragonadal germ cell cancer 11.4
40 malignant cardiac germ cell tumor 11.4
41 malignant gastric germ cell tumor 11.4
42 central nervous system adult germ cell tumor 11.4
43 testicular malignant germ cell cancer 11.3
44 malignant germ cell tumor of the cervix uteri 11.3
45 malignant pineal area germ cell neoplasm 11.3
46 central nervous system childhood germ cell tumor 11.3
47 childhood germ cell brain tumor 11.3
48 malignant childhood germ cell neoplasm 11.3
49 vaginal yolk sac tumor 11.2
50 retroperitoneal germ cell neoplasm 11.2

Graphical network of the top 20 diseases related to Germ Cell Cancer:



Diseases related to Germ Cell Cancer

Symptoms & Phenotypes for Germ Cell Cancer

MGI Mouse Phenotypes related to Germ Cell Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.81 AFP AR CGA DMRT1 ESR2 IGF2
2 liver/biliary system MP:0005370 9.5 AFP AR ESR2 IGF2 KITLG POU5F1
3 reproductive system MP:0005389 9.36 AFP ALPG AR CGA DMRT1 ESR2

Drugs & Therapeutics for Germ Cell Cancer

Drugs for Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 244)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thiotepa Approved, Investigational Phase 4 52-24-4 5453
2
Cisplatin Approved Phase 4 15663-27-1 84093 441203 2767
3
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
4
Etoposide Approved Phase 4 33419-42-0 36462
5
Mesna Approved, Investigational Phase 4 3375-50-6 598
6
Cyclophosphamide Approved, Investigational Phase 4 50-18-0, 6055-19-2 2907
7
Carboplatin Approved Phase 4 41575-94-4 10339178 498142 38904
8
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
9
Vincristine Approved, Investigational Phase 4 2068-78-2, 57-22-7 5978
10
leucovorin Approved Phase 4 58-05-9 6006
11
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
12 Etoposide phosphate Phase 4
13 Antirheumatic Agents Phase 4
14 Tubulin Modulators Phase 4
15 Antimitotic Agents Phase 4
16 Antimetabolites Phase 4
17 Dermatologic Agents Phase 4
18 Vitamin B9 Phase 4
19 Folate Phase 4
20 Vitamin B Complex Phase 4
21 Folic Acid Antagonists Phase 4
22
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
23
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
24
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
25
Ofloxacin Approved Phase 3 82419-36-1 4583
26
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
27
Pembrolizumab Approved Phase 3 1374853-91-4
28
Gemcitabine Approved Phase 3 95058-81-4 60750
29
Promethazine Approved, Investigational Phase 3 60-87-7 4927
30
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
31
Pemetrexed Approved, Investigational Phase 3 150399-23-8, 137281-23-3 60843 446556
32
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
33
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
34
Vinblastine Approved Phase 3 865-21-4 241903 13342
35
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
36
Polyestradiol phosphate Approved Phase 3 28014-46-2
37
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
38
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
39
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
40
Tyrosine Approved, Investigational, Nutraceutical Phase 3 60-18-4 6057
41 Protective Agents Phase 3
42 Cytochrome P-450 Enzyme Inhibitors Phase 3
43 Neurotransmitter Agents Phase 3
44 Antidotes Phase 3
45 Gastrointestinal Agents Phase 3
46 Neurokinin-1 Receptor Antagonists Phase 3
47 Chelating Agents Phase 3
48 sodium thiosulfate Phase 3
49 Antioxidants Phase 3
50 Antitubercular Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 254)
# Name Status NCT ID Phase Drugs
1 SIOP CNS GCT II: Prospective Trial for the Diagnosis and Treatment of Children, Adolescents and Young Adults With Intracranial Germ Cell Tumors Unknown status NCT01424839 Phase 4 Carboplatin, Etoposide, Ifosfamide;Cisplatin, etoposide, Ifosfamide (standard);Cisplatin, Etoposide, Ifosfamide (high dose)
2 HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors Clinical and Molecular Risk-Tailored Intensive and Compressed Induction Chemotherapy Followed by Consolidation With Randomization to Either Single Cycle or to Three Tandem Cycles of Marrow-Ablative Chemotherapy With Autologous Hematopoietic Progenitor Cell Rescue Recruiting NCT02875314 Phase 4 Induction;Single Cycle Intensive Chemotherapy;Tandem 3 Cycle Intensive Chemotherapy
3 Protocol for the Treatment of Extracranial Germ Cell Tumours in Children and Adolescents (GC III) Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
4 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
5 A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors Unknown status NCT00053352 Phase 3 cisplatin;etoposide
6 A Study to Investigate the Efficacy and Tolerability of Two Dose Levels of Lerisetron Compared With Granisetron in Patients Receiving Radiotherapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
7 Randomized Double-Blind Controlled Phase III Trial of Hyperbaric Oxygen Therapy in Patients Suffering Long-Term Adverse Effects of Radiotherapy for Pelvic Cancer (HOT II) Unknown status NCT01087268 Phase 3
8 Trial of Imaging and Schedule in Seminoma Testis Unknown status NCT00589537 Phase 3
9 SIOP Intracranial Germ Cell Tumours Protocol Completed NCT00293358 Phase 3 carboplatin;cisplatin;etoposide phosphate;ifosfamide
10 INTERNATIONAL RANDOMIZED STUDY FOR THE SALVAGE TREATMENT OF GERM CELL TUMOURS Completed NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
11 A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
12 A Randomized, Prospective Double-Blind, Placebo-Controlled Trial of Prophylactic Oral Levofloxacin Following Chemotherapy for Lymphoma and Solid Tumors Completed NCT00005590 Phase 3 levofloxacin
13 A Randomized Phase III Toxicity Study of Day 2, 3, 8, 15 Short (30 Minute) Versus Day 1, 2, 3 Long (72 Hours) Infusion Bleomycin for Patients With IGCCCG Good Prognosis Germ Cell Tumors, TE3 Completed NCT00324298 Phase 3 cisplatin;etoposide
14 Carboplatin in the Adjuvant Treatment of Stage I Seminoma: A Radomized Comparison of Single Agent Carboplatin With Radiotherapy in the Adjuvant Treatment of Stage I Seminoma of the Testis, Following Orchidectomy Completed NCT00003014 Phase 3 carboplatin
15 RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
16 Phase III, Double-Blind, Placebo-Controlled, Crossover Study Evaluating Aprepitant in Combination With a 5HT3 & Dexamethasone in Patients With Germ Cell Tumors Undergoing 5 Day Cisplatin-Based Chemotherapy Regimen Completed NCT00572572 Phase 3 Aprepitant;Placebo
17 A Randomized Phase III Study of Sodium Thiosulfate for the Prevention of Cisplatin-Induced Ototoxicity in Children Completed NCT00716976 Phase 3 sodium thiosulfate
18 Phase 3 Accelerated BEP: A Randomised Phase 3 Trial of Accelerated Versus Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours Recruiting NCT02582697 Phase 3 Bleomycin (active name: Bleomycin Sulfate);Etoposide;Cisplatin;Pegylated G-CSF (Pegfilgrastim);Filgrastim
19 A Multicenter, Prospective, Randomized Trial Comparing Paclitaxel and Carboplatin or Bleomycin, Etoposide and Cisplatin in the Treatment of Malignant Ovarian Germ Cell Tumors Recruiting NCT02429687 Phase 3 Paclitaxel;Carboplatin;Bleomycin;Etoposide;Cisplatin
20 A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
21 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
22 A Randomized, Open-Label, Phase 3 Study of Pralsetinib Versus Standard of Care for First Line Treatment of RET Fusion-positive, Metastatic Non-Small Cell Lung Cancer Recruiting NCT04222972 Phase 3 Pralsetinib;Carboplatin;Cisplatin;Pemetrexed;Pembrolizumab;Gemcitabine
23 A Single Group Trial Evaluating One Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Tumours of the Testis (NSGCTT) Active, not recruiting NCT01726374 Phase 3 BEP(500)
24 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Active, not recruiting NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
25 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
26 Randomized, Double Blinded, Placebo-Controlled Trial of Antibacterial Prophylaxis for the Prevention of Bacterial Infections in the Post-Engraftment Phase After Allogeneic Hematopoeitic Stem Cell Transplantation Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
27 Sorafenib (NEXAVAR) Monotherapy in Patients With Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy Unknown status NCT00772694 Phase 2 sorafenib
28 A Novel Single Arm Phase II Study for Relapsed Germ Cell Tumours With Poor Prognosis Unknown status NCT01782339 Phase 2 Combination Chemotherapy
29 Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
30 A Prospective Multicenter Phase II Trial of Gemcitabine, Cisplatin, and Ifosfamide (GIP) in Patients With Relapsed Non-Seminomatous Germ-Cell Tumors (NSGCT) and a Predicted Favorable Prognosis Unknown status NCT00127049 Phase 2 gemcitabine, ifosfamide, cisplatin, G-CSF
31 High-Dose Chemotherapy With Tandem Peripheral Blood Stem Cell (PBSC) Rescue for the Treatment of High-Risk Pediatric Solid Tumors. Unknown status NCT00179816 Phase 1, Phase 2 High-Dose Chemotherapy with Tandem PBSC Rescue.
32 Clinical Correlative Studies In Primary Central Nervous System Germ Cell Tumors: The Third International CNS Germ Cell Tumor Study Group Protocol Unknown status NCT00025324 Phase 2 carboplatin;cyclophosphamide;etoposide;thiotepa
33 Tandem High-Dose Chemotherapy (HDCT) With Peripheral-Blood Stem-Cell Rescue for Patients With Metastatic Germ-Cell Tumors Failing First-Line Treatment Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
34 An Open Label, Randomized, Phase 2 Study of the Anti-Programmed Death-Ligand 1 (PD-L1) Durvalumab, Alone or in Combination With Tremelimumab, in Patients With Advanced and Relapsed Germ Cell Tumors Unknown status NCT03081923 Phase 2 Durvalumab;Tremelimumab
35 Phase II Study of Single-agent Pazopanib (Votrient®) for Patients With Relapsed or Refractory Germ-cell Tumors (GCT). Unknown status NCT01743482 Phase 2 Pazopanib
36 Salvage Chemotherapy for Poor Prognosis Germ Cell Tumors - A Phase I-II Sequential Chemotherapy Protocol of Bevacizumab (Avastin) Plus High-dose ICE (Ifosfamide - Carboplatin - Etoposide) Intensification Unknown status NCT01966913 Phase 1, Phase 2 Bevacizumab;ICE chemotherapy regimen
37 A Prospective Phase II Trial of Cabazitaxel in Male Patients With Chemotherapy Pre-treated Metastatic Nonseminomatous Germ-cell Tumors Unknown status NCT02115165 Phase 2 Cabazitaxel
38 Prospective Open-Labeled Non Randomised Phase-II Study of SU011248 (Sunitinib) in Male Patients With Relapsed or Cisplatin-Refractory Germ Cell Cancer - A CUOG / GTCSG Cooperative Phase II Study - Completed NCT00371553 Phase 2 SU011248 (Sunitinib)
39 Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors With Paclitaxel, Ifosfamide and Carboplatin Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
40 High-Dose Cisplatin, Etoposide and Bleomycin (HD-PEB) Combined With Amifostine in Children With High-Risk Malignant Germ Cell Tumors - A POG Pilot Study Completed NCT00003811 Phase 2 amifostine trihydrate;cisplatin;etoposide
41 Brentuximab Vedotin (SGN-35) as Salvage Therapy for Males With Advanced and Platinum-resistant Germ-cell Tumors. An Open Label, Single Group, Phase 2 Trial. Completed NCT01851200 Phase 2 Brentuximab Vedotin
42 Phase II Study of Everolimus in Refractory Testicular Germ Cell Cancer. Completed NCT01466231 Phase 2 Everolimus
43 PHASE II TRIAL WITH DOCETAXEL IN PATIENTS WITH RELAPSING GERM CELL CANCER Completed NCT00002903 Phase 2 docetaxel
44 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
45 Phase II Study of Gemcitabine, Carboplatin and VELIPARIB (ABT-888) in Refractory Testicular Germ Cell Cancer Completed NCT02860819 Phase 2 Veliparib;Gemcitabine;Carboplatin
46 A Single Arm, Open-label Multicenter Phase II Trial of Everolimus in Patients With Relapsed/Refractory Germ Cell Cancer Completed NCT01242631 Phase 2 Everolimus
47 High Dose Carboplatin, Etoposide, Cyclophosphamide and Autologous Bone Marrow Transplantation for Relapsed and Refractory Germ Cell Cancer: A Phase II Pilot Study Completed NCT00002943 Phase 2 carboplatin;cyclophosphamide;etoposide
48 Phase II Study of Avelumab in Multiple Relapsed/Refractory Testicular Germ Cell Cancer. Completed NCT03403777 Phase 2 Avelumab
49 Phase II Study of Oxaliplatin Plus Bevacizumab Salvage Chemotherapy in Patients With Germ Cell Tumors Completed NCT00393861 Phase 2 Bevacizumab and Oxaliplatin
50 Phase II Study of Combined Oxaliplatin and Paclitaxel for Metastatic Germ Cell Tumors Completed NCT00611962 Phase 2 Oxaliplatin, Paclitaxel

Search NIH Clinical Center for Germ Cell Cancer

Cochrane evidence based reviews: neoplasms, germ cell and embryonal

Genetic Tests for Germ Cell Cancer

Anatomical Context for Germ Cell Cancer

MalaCards organs/tissues related to Germ Cell Cancer:

40
Testis, Bone, Lymph Node, Bone Marrow, Ovary, T Cells, Liver

Publications for Germ Cell Cancer

Articles related to Germ Cell Cancer:

(show top 50) (show all 1291)
# Title Authors PMID Year
1
Results of retroperitoneal lymph node dissection after chemotherapy in patients with pure seminoma in the orchidectomy specimen but elevated serum alpha-fetoprotein. 54 61
19493258 2009
2
Outcome analysis for patients with elevated serum tumor markers at postchemotherapy retroperitoneal lymph node dissection. 54 61
16135481 2005
3
[Diagnosis and primary treatment of testicular tumor]. 54 61
15592706 2004
4
Early predicted time to normalization of tumor markers predicts outcome in poor-prognosis nonseminomatous germ cell tumors. 61 54
15302906 2004
5
Down-regulation of estrogen receptor beta and transcriptional coregulator SNURF/RNF4 in testicular germ cell cancer. 54 61
14644130 2003
6
Analysis of the polymorphic CAG repeat length in the androgen receptor gene in patients with testicular germ cell cancer. 61 54
12385020 2002
7
Nuclear DNA content and proliferative potential of human carcinoma in situ cells in testes of intersex children. 61 54
11374808 2001
8
HCG induced hyperthyreosis in germ cell cancer. 61 54
11326684 2000
9
Semen quality and reproductive hormones before orchiectomy in men with testicular cancer. 54 61
10071288 1999
10
FGF4 dissociates anti-tumorigenic from differentiation signals of retinoic acid in human embryonal carcinomas. 54 61
9715278 1998
11
Salvage management of patients with relapsing testicular germ cell tumors. 61
33742980 2021
12
Risk of second primary malignancies of adolescent and young adult patients with germ cell cancer: A US population-based analysis. 61
32928566 2021
13
Lung autotransplantation for bronchial necrosis after radiotherapy: a case report. 61
33796902 2021
14
The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer. 61
33650343 2021
15
Screening for cancers with a good prognosis: The case of testicular germ cell cancer. 61
33710779 2021
16
Primary intracranial pure endodermal sinus tumor: a retrospective series of 6 cases in a single center and a systematic review of overall survival. 61
33753128 2021
17
Surgical Management of Retrocrural Disease in Germ Cell Tumors: Outcomes and Evolution of Practice. 61
33180596 2021
18
[Using preorchiectomy tumor marker serum concentrations for International Germ Cell Consensus Classification (IGCCCG) risk group assignment results in significant numbers of up- and downstaging]. 61
33427889 2021
19
Survival and New Prognosticators in Metastatic Seminoma: Results From the IGCCCG-Update Consortium. 61
33729863 2021
20
Multimodality treatment outcome in patients with primary malignant mediastinal germ cell tumor in adults. 61
33029924 2021
21
Incidence and clinical pattern of contralateral synchronous and metachronous germ cell testicular cancer. 61
33189529 2021
22
Cisplatin, Gemcitabine, and Paclitaxel as a Salvage Second-Line Therapy for Metastatic Germ-Cell Cancer. 61
32636079 2021
23
Improved outcomes in metastatic germ cell cancer: results from a large cohort study. 61
32772232 2021
24
Frequent azoospermia in patients with testicular germ cell cancer and a history of cryptorchidism: a report of nine cases and review of the literature. 61
33630670 2021
25
Neutropenic sepsis rates in patients receiving bleomycin, etoposide and cisplatin chemotherapy using olanzapine and reduced doses of dexamethasone compared to a standard antiemetic regimen. 61
32668505 2021
26
Prophylactic corticosteroid use prevents engraftment syndrome in patients after autologous stem cell transplantation. 61
32979278 2021
27
A phase 1 study of combined guadecitabine and cisplatin in platinum refractory germ cell cancer. 61
33135391 2021
28
Management of Germ Cell Tumours of the Testis in Adult Patients. German Clinical Practice Guideline Part I: Epidemiology, Classification, Diagnosis, Prognosis, Fertility Preservation, and Treatment Recommendations for Localized Stages. 61
33412555 2021
29
Patterns of relapse and treatment outcome after active surveillance or adjuvant carboplatin for stage I seminoma: a retrospective study of the Spanish Germ Cell Cancer Group. 61
32462393 2021
30
Three-Dimensional Cultivation of Germ Cell Cancer Cell Lines as Hanging Drops. 61
32852758 2021
31
Evaluation of Chemotherapeutic Drugs for Treatment of (Cisplatin-Resistant) Germ Cell Cancer Cell Lines. 61
32852760 2021
32
Quality improvement for cancer multidisciplinary teams: lessons learned from the Anglian Germ Cell Cancer Collaborative Group. 61
32989228 2021
33
The impact of a supranetwork multidisciplinary team (SMDT) on decision-making in testicular cancers: a 10-year overview of the Anglian Germ Cell Cancer Collaborative Group (AGCCCG). 61
32989229 2021
34
Low Survival in Poor Prognosis Metastatic Germ Cell Cancer in Belarus. 61
33434070 2021
35
Cultivation of Testicular Germ Cell Cancer Cell Lines and Establishment of Gene-Edited Subclones Using CRISPR/Cas9. 61
32852759 2021
36
Outcomes of adolescent males with extracranial metastatic germ cell tumors: A report from the Malignant Germ Cell Tumor International Consortium. 61
33079404 2021
37
Immature teratoma of the ovary in a 1 year and 9-month-old child: a case report and review of the literature. 61
33542817 2021
38
A Circulating MicroRNA Panel for Malignant Germ Cell Tumor Diagnosis and Monitoring. 61
32852767 2021
39
The Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Metastatic Testicular Cancer. 61
33622996 2020
40
Yolk sac tumor of the fourth ventricle in a 3-year-old boy: imaging features. 61
32253490 2020
41
Utility of Serum miR-371a-3p in Predicting Relapse on Surveillance in Patients with Clinical Stage I Testicular Germ Cell Cancer. 61
33288479 2020
42
Tumors Widely Express Hundreds of Embryonic Germline Genes. 61
33348709 2020
43
[French ccAFU guidelines - update 2020-2022: penile cancer]. 61
33349426 2020
44
[French ccAFU guidelines - update 2020-2022: testicular germ cell tumors]. 61
33349427 2020
45
Imaging in gynecological disease: clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors. 61
33142349 2020
46
A Case of Primary Sinonasal Yolk Sac Tumor. 61
32910044 2020
47
Successful emergency endovascular aortic repair for intratumoral hemorrhage in extensive retroperitoneal mass of testicular origin. 61
33160340 2020
48
Intraoperative and early postoperative complications in postchemotherapy retroperitoneal lymphadenectomy among patients with germ cell tumors using validated grading classifications. 61
32940929 2020
49
Successful treatment of non-midline primary malignant germ cell tumors with yolk sac components in neonates: report of 2 cases. 61
33126205 2020
50
Venous Thromboembolism During Chemotherapy for Testicular Cancer: A Population-Based Study. 61
32387044 2020

Variations for Germ Cell Cancer

Expression for Germ Cell Cancer

Search GEO for disease gene expression data for Germ Cell Cancer.

Pathways for Germ Cell Cancer

GO Terms for Germ Cell Cancer

Biological processes related to Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 9.8 MIR373 MIR372 MIR371A MIR367 H19
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.8 POU5F1 IGF2 ESR2 DMRT1 ATF7IP AR
3 positive regulation of transcription by RNA polymerase II GO:0045944 9.76 POU5F1 IGF2 FGF4 ESR2 DMRT1 CSF3
4 male gonad development GO:0008584 9.61 KITLG DMRT1 AR
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.54 KITLG IGF2 CSF3
6 intracellular estrogen receptor signaling pathway GO:0030520 9.46 ESR2 AR
7 positive regulation of protein kinase B signaling GO:0051897 9.35 KITLG IGF2 H19 FGF4 CSF3
8 intracellular steroid hormone receptor signaling pathway GO:0030518 9.26 ESR2 AR
9 positive regulation of cell proliferation GO:0008284 9.17 MIR372 KITLG IGF2 FGF4 CSF3 CGA

Molecular functions related to Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 alkaline phosphatase activity GO:0004035 8.96 ALPP ALPG
2 growth factor activity GO:0008083 8.92 KITLG IGF2 FGF4 CSF3

Sources for Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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