Germ Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GRM002 MIFTS: 39	Germ Cell Tumor Categories: Cancer diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Germ Cell Tumor

MalaCards integrated aliases for Germ Cell Tumor:

Name: Germ Cell Tumor ⁵⁸ ²⁸ ¹⁶ ⁷⁵

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

UMLS via Orphanet ⁷² C0740345

Orphanet ⁵⁸ ORPHA3399

EFO ¹⁶ EFO_0000514

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Summaries for Germ Cell Tumor

MalaCards based summary: Germ Cell Tumor is related to mixed germ cell cancer and testicular germ cell cancer. An important gene associated with Germ Cell Tumor is DMRT1 (Doublesex And Mab-3 Related Transcription Factor 1). The drugs Cisplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and lymph node, and related phenotype is Increased cell viability after pRB stimulation.

Wikipedia: ⁷⁵ Germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ-cell tumors can be cancerous or... more...

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Related Diseases for Germ Cell Tumor

Diseases related to Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 603)

#	Related Disease	Score	Top Affiliating Genes
1	mixed germ cell cancer	32.7	KIT DMRT1
2	testicular germ cell cancer	32.0	STK11 KIT FGFR3 DMRT1
3	testicular germ cell tumor	31.7	TGCT1 STK11 STK10 KIT FGFR3
4	spermatocytoma	31.4	KIT FGFR3 DMRT1
5	testicular cancer	31.4	STK11 KIT FGFR3 DMRT1
6	gonadoblastoma	30.8	KIT DMRT1
7	ovarian gonadoblastoma	30.2	KIT DMRT1
8	testicular disease	29.9	KIT DMRT1
9	ovarian germ cell cancer	11.9
10	testicular seminoma	11.8
11	malignant pineal area germ cell neoplasm	11.7
12	extragonadal germ cell cancer	11.7
13	nonseminomatous germ cell tumor	11.7
14	testicular germ cell tumor 1	11.7
15	malignant non-dysgerminomatous germ cell tumor of ovary	11.6
16	ovarian mixed germ cell neoplasm	11.6
17	malignant germ cell tumor of the cervix uteri	11.6
18	childhood central nervous system mixed germ cell tumor	11.5
19	central nervous system germ cell tumor	11.5
20	endodermal sinus tumor	11.5
21	childhood testicular germ cell tumor	11.5
22	childhood ovarian germ cell tumor	11.5
23	germ cell cancer	11.5
24	malignant gastric germ cell tumor	11.5
25	adult central nervous system mixed germ cell tumor	11.5
26	malignant germ cell tumor of the vagina	11.5
27	malignant germ cell tumor of the corpus uteri	11.5
28	malignant dysgerminomatous germ cell tumor of the ovary	11.5
29	childhood germ cell cancer	11.5
30	extragonadal nonseminomatous germ cell tumor	11.5
31	malignant cardiac germ cell tumor	11.4
32	ovarian primitive germ cell tumor	11.4
33	polyembryoma	11.4
34	seminoma	11.4
35	pigmented villonodular synovitis	11.4
36	testicular pure germ cell tumor	11.3
37	central nervous system adult germ cell tumor	11.3
38	retroperitoneal germ cell neoplasm	11.3
39	childhood testicular mixed germ cell tumor	11.3
40	malignant childhood germ cell neoplasm	11.3
41	primary germ cell tumor of central nervous system	11.3
42	mixed germ cell tumor of central nervous system	11.3
43	teratocarcinoma	11.3
44	choriocarcinoma	11.3
45	germinoma	11.3
46	childhood cns embryonal cell carcinoma	11.3
47	childhood germ cell brain tumor	11.3
48	gonadal germ cell tumor	11.3
49	dysgerminoma	11.3
50	testicular yolk sac tumor	11.2

Graphical network of the top 20 diseases related to Germ Cell Tumor:

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Symptoms & Phenotypes for Germ Cell Tumor

GenomeRNAi Phenotypes related to Germ Cell Tumor according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased cell viability after pRB stimulation	GR00230-A-1	8.8	KIT STK10 STK11

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Drugs & Therapeutics for Germ Cell Tumor

Drugs for Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 258)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cisplatin

Approved

Phase 3

15663-27-1

2767 5702198 441203

Etoposide

Approved

Phase 3

33419-42-0

36462

Granisetron

Approved, Investigational

Phase 3

109889-09-0

3510 5284566

Levofloxacin

Approved, Investigational

Phase 3

100986-85-4

149096

Ofloxacin

Approved

Phase 3

82419-36-1

4583

Coenzyme M

Approved, Investigational

Phase 3

3375-50-6

598 23662354

Diphenhydramine

Approved, Investigational

Phase 3

147-24-0, 58-73-1

3100

Promethazine

Approved, Investigational

Phase 3

60-87-7

4927

Bleomycin

Approved, Investigational

Phase 3

9041-93-4, 11056-06-7

5360373

Ifosfamide

Approved

Phase 3

3778-73-2

3690

Vinblastine

Approved

Phase 3

865-21-4

241903 13342

Estradiol

Approved, Investigational, Vet_approved

Phase 3

50-28-2

5757

Ethinylestradiol

Approved

Phase 3

57-63-6

5991

Polyestradiol phosphate

Approved

Phase 3

28014-46-2

Norgestimate

Approved, Investigational

Phase 3

35189-28-7

6540478

Moxifloxacin

Approved, Investigational

Phase 3

186826-86-8, 354812-41-2, 151096-09-2

152946

Palifosfamide

Investigational

Phase 3

31645-39-3

100427

Etoposide phosphate

Phase 3

16760419

Hormones

Phase 3

Calcium, Dietary

Phase 3

Cytochrome P-450 Enzyme Inhibitors

Phase 3

Histamine H2 Antagonists

Phase 3

Anti-Bacterial Agents

Phase 3

Anti-Infective Agents

Phase 3

Estradiol 3-benzoate

Phase 3

Estradiol 17 beta-cypionate

Phase 3

Contraceptives, Oral, Combined

Phase 3

Contraceptives, Oral

Phase 3

Contraceptive Agents

Phase 3

Norgestimate, ethinyl estradiol drug combination

Phase 3

Calcium

Nutraceutical

Phase 3

7440-70-2

271

Magnesium sulfate

Approved, Investigational, Vet_approved

Phase 1, Phase 2

7487-88-9

Ranitidine

Approved, Withdrawn

Phase 1, Phase 2

66357-59-3, 82530-72-1, 66357-35-5

3001055 5039

Furosemide

Approved, Vet_approved

Phase 1, Phase 2

54-31-9

3440

Chlorpheniramine

Approved

Phase 1, Phase 2

113-92-8, 132-22-9

2725

Topotecan

Approved, Investigational

Phase 2

123948-87-8, 119413-54-6

60699 60700

Paclitaxel

Approved, Vet_approved

Phase 2

33069-62-4

36314

Levoleucovorin

Approved, Experimental, Investigational

Phase 2

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Fluorouracil

Approved

Phase 2

51-21-8

3385

Oxaliplatin

Approved, Investigational

Phase 2

61825-94-3

43805 11947679 6857599

Ondansetron

Approved, Withdrawn

Phase 2

99614-02-5

4595

Sargramostim

Approved, Investigational

Phase 2

123774-72-1

Sunitinib

Approved, Investigational

Phase 2

557795-19-4

5329102

Gemcitabine

Approved

Phase 2

95058-81-4, 122111-03-9

60750

Arsenic trioxide

Approved, Investigational

Phase 2

1327-53-3

518740

Docetaxel

Approved, Investigational

Phase 2

114977-28-5

148124

Vincristine

Approved, Investigational

Phase 2

2068-78-2, 57-22-7

5978

Darbepoetin alfa

Approved, Investigational

Phase 2

209810-58-2

Alemtuzumab

Approved, Investigational

Phase 2

216503-57-0

Prednisolone phosphate

Approved, Vet_approved

Phase 2

302-25-0

Interventional clinical trials:

(show top 50) (show all 248)

#	Name	Status	NCT ID	Phase	Drugs
1	Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer	Unknown status	NCT00003643	Phase 2, Phase 3	cisplatin;etoposide;paclitaxel
2	Protocol for the Treatment of Extracranial Germ Cell Tumours in Children and Adolescents (GC III)	Unknown status	NCT00274950	Phase 3	carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
3	Trial of Imaging and Schedule in Seminoma Testis	Unknown status	NCT00589537	Phase 3
4	Randomized Double-Blind Controlled Phase III Trial of Hyperbaric Oxygen Therapy in Patients Suffering Long-Term Adverse Effects of Radiotherapy for Pelvic Cancer (HOT II)	Unknown status	NCT01087268	Phase 3
5	A Study to Investigate the Efficacy and Tolerability of Two Dose Levels of Lerisetron Compared With Granisetron in Patients Receiving Radiotherapy for Stage I Seminoma	Unknown status	NCT00004219	Phase 3	granisetron hydrochloride;lerisetron
6	A Single Group Trial Evaluating One Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Tumours of the Testis (NSGCTT)	Unknown status	NCT01726374	Phase 3	BEP(500)
7	A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors	Completed	NCT00053352	Phase 3	cisplatin;etoposide
8	RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS	Completed	NCT00002596	Phase 3	carboplatin;cisplatin;cyclophosphamide;etoposide
9	A Randomized Phase III Study of Sodium Thiosulfate for the Prevention of Cisplatin-Induced Ototoxicity in Children	Completed	NCT00716976	Phase 3	sodium thiosulfate
10	A Randomized, Prospective Double-Blind, Placebo-Controlled Trial of Prophylactic Oral Levofloxacin Following Chemotherapy for Lymphoma and Solid Tumors	Completed	NCT00005590	Phase 3	levofloxacin
11	INTERNATIONAL RANDOMIZED STUDY FOR THE SALVAGE TREATMENT OF GERM CELL TUMOURS	Completed	NCT00002566	Phase 3	carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
12	A Randomized Phase III Toxicity Study of Day 2, 3, 8, 15 Short (30 Minute) Versus Day 1, 2, 3 Long (72 Hours) Infusion Bleomycin for Patients With IGCCCG Good Prognosis Germ Cell Tumors, TE3	Completed	NCT00324298	Phase 3	cisplatin;etoposide
13	A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer	Completed	NCT00003941	Phase 3	cisplatin;etoposide;ifosfamide
14	Carboplatin in the Adjuvant Treatment of Stage I Seminoma: A Radomized Comparison of Single Agent Carboplatin With Radiotherapy in the Adjuvant Treatment of Stage I Seminoma of the Testis, Following Orchidectomy	Completed	NCT00003014	Phase 3	carboplatin
15	A Randomized Double Blinded Trial of Topical Caphosol to Prevent Oral Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation	Completed	NCT01305200	Phase 3	supersaturated calcium phosphate rinse
16	A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors	Recruiting	NCT03067181	Phase 3	Carboplatin;Cisplatin;Etoposide
17	A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors	Recruiting	NCT02375204	Phase 3	paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
18	Phase 3 Accelerated BEP: A Randomised Phase 3 Trial of Accelerated Versus Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours	Recruiting	NCT02582697	Phase 3	Bleomycin (active name: Bleomycin Sulfate);Etoposide;Cisplatin;Pegylated G-CSF (Pegfilgrastim);Filgrastim
19	A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors	Active, not recruiting	NCT00104676	Phase 3	cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
20	A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors	Terminated	NCT00072215	Phase 3	cisplatin;ifosfamide;paclitaxel;vinblastine
21	Randomized, Double Blinded, Placebo-Controlled Trial of Antibacterial Prophylaxis for the Prevention of Bacterial Infections in the Post-Engraftment Phase After Allogeneic Hematopoeitic Stem Cell Transplantation	Terminated	NCT00324324	Phase 3	moxifloxacin hydrochloride;Placebo
22	Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer	Unknown status	NCT00551122	Phase 1, Phase 2	cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
23	Tandem High-Dose Chemotherapy (HDCT) With Peripheral-Blood Stem-Cell Rescue for Patients With Metastatic Germ-Cell Tumors Failing First-Line Treatment	Unknown status	NCT01172912	Phase 2	carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
24	Clinical Correlative Studies In Primary Central Nervous System Germ Cell Tumors: The Third International CNS Germ Cell Tumor Study Group Protocol	Unknown status	NCT00025324	Phase 2	carboplatin;cyclophosphamide;etoposide;thiotepa
25	Salvage Chemotherapy for Poor Prognosis Germ Cell Tumors - A Phase I-II Sequential Chemotherapy Protocol of Bevacizumab (Avastin) Plus High-dose ICE (Ifosfamide - Carboplatin - Etoposide) Intensification	Unknown status	NCT01966913	Phase 1, Phase 2	Bevacizumab;ICE chemotherapy regimen
26	High-Dose Chemotherapy With Tandem Peripheral Blood Stem Cell (PBSC) Rescue for the Treatment of High-Risk Pediatric Solid Tumors.	Unknown status	NCT00179816	Phase 1, Phase 2	High-Dose Chemotherapy with Tandem PBSC Rescue.
27	A Prospective Multicenter Phase II Trial of Gemcitabine, Cisplatin, and Ifosfamide (GIP) in Patients With Relapsed Non-Seminomatous Germ-Cell Tumors (NSGCT) and a Predicted Favorable Prognosis	Unknown status	NCT00127049	Phase 2	gemcitabine, ifosfamide, cisplatin, G-CSF
28	Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer	Completed	NCT01037790	Phase 2	PD-0332991
29	Psychosexual Intervention for Gynecologic and Breast Cancer Patients	Completed	NCT01764802	Phase 2
30	Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors With Paclitaxel, Ifosfamide and Carboplatin	Completed	NCT00467051	Phase 2	Carboplatin;Ifosfamide;Paclitaxel
31	A Non-randomized Phase 2 Study of Alvocidib (Flavopiridol) Plus Oxaliplatin With or Without 5-FU and Leucovorin for Relapsed or Refractory Germ-Cell Tumors	Completed	NCT00957905	Phase 2	Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
32	A Phase II Study of Oxaliplatin in Children With Recurrent Solid Tumors	Completed	NCT00091182	Phase 2	oxaliplatin
33	Prevention of DMSO-Related Nausea and Vomiting by Prophylactic Administration of Ondansetron for Patients Receiving Autologous Cryopreserved Peripheral Blood Stem Cells	Completed	NCT00795769	Phase 2	ondansetron
34	Myeloablative Chemotherapy With Bone Marrow Rescue For Rare Poor-Prognosis Cancers	Completed	NCT00002515	Phase 2	carboplatin;thiotepa;topotecan hydrochloride
35	A Prospective Evaluation of a Palliative Radio-Surgical Approach for the Treatment of Gynecologic Malignancies	Completed	NCT01079832	Phase 2
36	High-Dose Thiotepa With Autologous Stem Cell Rescue in Patients With Malignancies Refractory to Conventional Chemotherapy	Completed	NCT00003173	Phase 2	thiotepa
37	Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor	Completed	NCT00453232	Phase 2	cisplatin;etoposide
38	Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients	Completed	NCT00470366	Phase 2	cisplatin;ifosfamide;paclitaxel
39	A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors	Completed	NCT00453310	Phase 2	sunitinib malate
40	Phase I/II Trial of Sequential Paclitaxel/Ifosfamide Followed by Dose-Escalated, Dose-Intensive Carboplatin, Paclitaxel and Ifosfamide With Stem Cell Support in Cisplatin-Resistant Germ Cell Tumor Patients	Completed	NCT00423852	Phase 1, Phase 2	carboplatin;ifosfamide;paclitaxel
41	Phase II Study Of Arsenic Trioxide In Patients With Refractory Germ Cell Malignancies	Completed	NCT00036842	Phase 2	arsenic trioxide
42	Phase II Study of Arsenic Trioxide in Neuroblastoma and Other Pediatric Solid Tumors	Completed	NCT00024258	Phase 2	arsenic trioxide
43	High Dose Carboplatin, Etoposide, Cyclophosphamide and Autologous Bone Marrow Transplantation for Relapsed and Refractory Germ Cell Cancer: A Phase II Pilot Study	Completed	NCT00002943	Phase 2	carboplatin;cyclophosphamide;etoposide
44	Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer	Completed	NCT00002931	Phase 2	carboplatin;etoposide;ifosfamide;paclitaxel
45	PHASE II TRIAL WITH DOCETAXEL IN PATIENTS WITH RELAPSING GERM CELL CANCER	Completed	NCT00002903	Phase 2	docetaxel
46	A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL	Completed	NCT00070096	Phase 2	ixabepilone
47	High-Dose Cisplatin, Etoposide and Bleomycin (HD-PEB) Combined With Amifostine in Children With High-Risk Malignant Germ Cell Tumors - A POG Pilot Study	Completed	NCT00003811	Phase 2	amifostine trihydrate;cisplatin;etoposide
48	PHASE I/II TRIAL OF SEQUENTIAL TAXOL/IFOSFAMIDE AND DOSEINTENSIVE CARBOPLATIN/ETOPOSIDE WITH STEM CELL SUPPORT IN CISPLATIN-RESISTANT GERM CELL TUMOR PATIENTS WITH UNFAVORABLE PROGNOSTIC FEATURES	Completed	NCT00002558	Phase 1, Phase 2	carboplatin;etoposide;ifosfamide;paclitaxel
49	INTENSIVE CHEMOTHERAPY FOR RELAPSED OR REFRACTORY GERM CELL TUMORS EMPLOYING HIGH-DOSE CARBOPLATIN, ETOPOSIDE, AND THIOTEPA WITH AUTOLOGOUS BONE MARROW RESCUE FOR PATIENTS 15 TO 60 YEARS OF AGE	Completed	NCT00002508	Phase 1, Phase 2	carboplatin;etoposide
50	High Dose Ifosfamide, Carboplatin and Etoposide With Amifostine Chemoprotection	Completed	NCT00003657	Phase 2	Amifostine;Carboplatin;Etoposide;Ifosfamide

Search NIH Clinical Center for Germ Cell Tumor

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Genetic Tests for Germ Cell Tumor

Genetic tests related to Germ Cell Tumor:

#	Genetic test	Affiliating Genes
1	Germ Cell Tumor ²⁸

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Anatomical Context for Germ Cell Tumor

Organs/tissues related to Germ Cell Tumor:

MalaCards : Testis, Ovary, Lymph Node, T Cells, Bone Marrow, Brain, Spinal Cord

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Publications for Germ Cell Tumor

Articles related to Germ Cell Tumor:

(show top 50) (show all 4121)

#	Title	Authors	PMID	Year
1	Lost in descent: Complications of cryptorchidism. ⁶²	Facer L...Rogers D	36345463	2023
2	Relationship between the timing of chemotherapy and surgical complications following surgical biopsy in children with malignant solid tumors. ⁶²	Hayashi K...Kawashima H	36184783	2023
3	A case of germinoma located in the fornix inducing transsynaptic atrophy of the Papez circuit. ⁶²	Kano S...Mori H	36425391	2023
4	Oxaliplatin related multiple focal nodular hyperplasia mimicking metastasis from a gastric cancer. ⁶²	Gonzalez-Ballesteros XA...Negreros-Osuna AA	35225712	2022
5	First-line salvage treatment options for germ cell tumor patients failing stage-adapted primary treatment : A comprehensive review compiled by the German Testicular Cancer Study Group. ⁶²	Pfister D...Oing C	35226138	2022
6	Feasibility of treating pediatric intracranial germ cell tumors in a middle-income country: The Jordanian experience. ⁶²	Amayiri N...Bartels U	36131594	2022
7	High prevalence of overweight/obesity and dyslipidemia in patients with intracranial germ cell tumors. ⁶²	Wang S...Zhu H	36088446	2022
8	Endodermal sinus tumor with pancreatic origin: A case report. ⁶²	Zahid MJ...Khan HB	36413894	2022
9	Role of Lactate Dehydrogenase in Identifying Relapse for Patients With Stage I Testicular Cancer on Surveillance. ⁶²	Bobrowski A...Hamilton RJ	35997696	2022
10	[Multimodal treatment of testicular cancer: chemotherapy, surgery or radiotherapy?] ⁶²	Nestler T...Seidel C	36224397	2022
11	A curious case of ovarian cysts. ⁶²	Hodges R...Watkins E	36412944	2022
12	Familial Male-limited Precocious Puberty (FMPP) and Testicular Germ Cell Tumors. ⁶²	Kooij CD...Verrijn Stuart AA	36071555	2022
13	Split-Tendon Medial Transposition of Lateral Rectus for Pediatric Complete Oculomotor Palsy. ⁶²	Zhang KX...Shah VS	36342135	2022
14	A Prospective Evaluation of Fatigue in Pediatric Brain Tumor Patients Treated With Radiation Therapy. ⁶²	Gandy K...Douglas Ris M	36285825	2022
15	Atypical cartilage in type II germ cell tumors of the mediastinum show significantly different patterns of IDH1/2 mutations from conventional chondrosarcoma. ⁶²	Warmke LM...Ulbright TM	35660795	2022
16	Testis-expressed gene 11 inhibits cisplatin-induced DNA damage and contributes to chemoresistance in testicular germ cell tumor. ⁶²	Kitayama S...Horie K	36319719	2022
17	Testis-sparing Surgery in Adult Patients with Germ Cell Tumors: Systematic Search of the Literature and Focused Review. ⁶²	Heidenreich A...Laguna MP	36418210	2022
18	Robotic post-chemotherapy retroperitoneal lymph node dissection for testicular cancer: A multicenter collaborative study. ⁶²	Ghoreifi A...Djaladat H	36437156	2022
19	Anesthesia for mandibular yolk sac tumor in children after radiotherapy and chemotherapy: A case report. ⁶²	Zhang S...Dai R	36408079	2022
20	Primary Retroperitoneal Lymph Node Dissection for Patients With Pathologic Stage II Nonseminomatous Germ Cell Tumor-N1, N2, and N3 Disease: Is Adjuvant Chemotherapy Necessary? ⁶²	Tachibana I...Cary C	35675585	2022
21	Growing teratoma syndrome - ovarian germ cell tumor. ⁶²	Shukkur N...Srinivas BH	36347301	2022
22	A comprehensive evaluation of sexual and reproductive outcomes following robot-assisted retroperitoneal lymph node dissection for nonseminomatous germ cell tumor. ⁶²	Mistretta FA...Musi G	35381697	2022
23	Endoscopic aqueductal membrane fenestration was effective for intractable hydrocephalus after removal of a nongerminomatous germ cell tumor exhibiting growing teratoma syndrome: a case report. ⁶²	Kajiwara S...Morioka M	36443673	2022
24	Burned-out germ cell tumor presenting with acute abdomen. ⁶²	Cimen SG...Han U	36282162	2022
25	Spontaneous rupture of a retroperitoneal lymph node metastasis causing massive hemorrhage in a patient with advanced mixed germ cell tumor. ⁶²	Filho LHCP...Sadi MV	35968525	2022
26	Case Report: A Giant Epignathus with a Well-Developed Skeleton of Head and Neck. ⁶²	Goto S...Kijima H	36412010	2022
27	Effect of the PARP inhibitor veliparib on germ cell tumor cell lines. ⁶²	Schmidtova S...Mego M	36276487	2022
28	CNS non-germinomatous germ cell tumor (NGGCT): Lessons from the recent past. ⁶²	Yeo KK...MacDonald SM	35512703	2022
29	Expanded endoscopic endonasal transtuberculum approach for resection of Germ cell tumor. ⁶²	Gimenez P...Abhinav K	36427692	2022
30	Isolated corpora cavernosa germ cell tumor metastasis requiring complex excision and reconstruction. ⁶²	Bieber C...Amend G	36281436	2022
31	Germ cell tumor with duodenal involvement: a rare case of gastrointestinal bleeding. ⁶²	Goncalves M...Rebelo A	36412989	2022
32	Metastatic germ cell tumor in ascitic effusion cytology- Is it that uncommon? ⁶²	Jindal A...Kaur Rana M	36308413	2022
33	Reply to Alireza Ghoreifi and Hooman Djaladat's Letter to the Editor re: Isamu Tachibana, Sean Q. Kern, Antoin Douglawi, et al. Primary Retroperitoneal Lymph Node Dissection for Patients with Pathologic Stage II Nonseminomatous Germ Cell Tumor-N1, N2, and N3 Disease: Is Adjuvant Chemotherapy Necessary? J Clin Oncol. In press. https://doi.org/10.1200/JCO.22.00118: Is Retroperitoneal Lymph Node Dissection Without Adjuvant Chemotherapy Enough for All Patients with Pathologic Stage II Nonseminoma Germ Cell Tumor? ⁶²	Tachibana I...Cary C	36195478	2022
34	Re: Isamu Tachibana, Sean Q. Kern, Antoin Douglawi, et al. Primary Retroperitoneal Lymph Node Dissection for Patients with Pathologic Stage II Nonseminomatous Germ Cell Tumor-N1, N2, and N3 Disease: Is Adjuvant Chemotherapy Necessary? J Clin Oncol. In press. https://doi.org/10.1200/JCO.22.00118: Is Retroperitoneal Lymph Node Dissection Without Adjuvant Chemotherapy Enough for All Patients with Pathologic Stage II Nonseminoma Germ Cell Tumor? ⁶²	Ghoreifi A...Djaladat H	36195480	2022
35	[Expert consensus on specimen handling and pathological diagnosis of germ cell tumor of testis]. ⁶²		36207904	2022
36	Precocious puberty due to intracranial germ cell tumors: a case-control study. ⁶²	Chen H...Zhong LY	35938923	2022
37	Updates in 2022 on the staging of testicular germ cell tumors. ⁶²	Canete Portillo S...Magi-Galluzzi C	35926809	2022
38	18F-FDG PET/CT Showing Rare Mediastinal Growing Teratoma Syndrome Following Chemotherapy. ⁶²	Sasahara M...Harada M	36268930	2022
39	DUSP5 and PHLDA1 mutations in mature cystic teratomas of the ovary identified on whole-exome sequencing may explain teratoma characteristics. ⁶²	Wang WC...Lai YC	36289533	2022
40	Posterior mediastinal teratoma presenting as an abdominal mass in a child: A case report. ⁶²	Haloua M...Boubbou M	35965932	2022
41	Applications of the Grading Scales for the Detection of Ototoxicity in Children after Treatment of Neuroblastoma and Extracranial Germinal Tumor. ⁶²	Polski B...Januszkiewicz-Lewandowska D	36191558	2022
42	Phase II study of Disulfiram and Cisplatin in Refractory Germ Cell Tumors. The GCT-SK-006 phase II trial. ⁶²	Mego M...Chovanec M	35763178	2022
43	Accuracy of germ cell tumor histology and stage within a Canadian cancer registry. ⁶²	Holland P...Wood LA	36218319	2022
44	Evaluation of miR-371a-3p to predict viable germ cell tumor in patients with pure seminoma receiving retroperitoneal lymph node dissection. ⁶²	Konneh B...Bagrodia A	36254623	2022
45	[Analysis of 42 cases of childhood superior vena cava syndrome associated with mediastinal malignancy]. ⁶²	Yang QS...Gao YJ	36207849	2022
46	All pineal tumors expressing germ cell tumor markers are not necessarily germ cell tumors: histopathological and molecular study of a midline primary intracranial sarcoma DICER1-mutant. ⁶²	Wolf T...Lhermitte B	36307659	2022
47	Primary vaginal endodermal sinus tumor in infants and children: experience from a tertiary center. ⁶²	Yin M...Zhang X	36207682	2022
48	Ruptured dermoid cyst of ovary developing into chronic peritonitis; a rare complication diagnosed by contrast CT: A case study. ⁶²	Rai K...Timilsina B	36268424	2022
49	Somatic-type malignancies in testicular germ cell tumors. ⁶²	Guo CC...Czerniak B	35803413	2022
50	[Genetic analysis and pathological features of one 46,XX testicular disorder of sex development cases with prostate germ cell tumor]. ⁶²	Xie L...Wang H	36082576	2022

Sources

Genes for Germ Cell Tumor

Genes related to Germ Cell Tumor (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DMRT1	Doublesex And Mab-3 Related Transcription Factor 1	Protein Coding	16.55	GeneCards inferred via : Disorders Publications (show sections)
2	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	16.55	GeneCards inferred via : Disorders Publications (show sections)
3	TGCT1	Testicular Germ Cell Tumor Susceptibility 1	Genetic Locus	8.64	GeneCards inferred via : Gene name (show sections)
4	MGCT	Male Germ Cell Tumor	Genetic Locus	8.43	GeneCards inferred via : Gene name (show sections)
5	HSERVPRODH	Human-Specific Endogenous Retroviral Insert PRODH Enhancer	Functional Element	7.92	GeneCards inferred via : Summaries (show sections)
6	XAGE2	X Antigen Family Member 2	Protein Coding	7.92	GeneCards inferred via : Summaries (show sections)
7	GOLT1B	Golgi Transport 1B	Protein Coding	7.86	GeneCards inferred via : Gene name (show sections)
8	INTS13	Integrator Complex Subunit 13	Protein Coding	7.86	GeneCards inferred via : Gene name (show sections)
9	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	7.78	GeneCards inferred via : Disorders (show sections)
10	STK10	Serine/Threonine Kinase 10	Protein Coding	7.78	GeneCards inferred via : Disorders (show sections)
11	STK11	Serine/Threonine Kinase 11	Protein Coding	7.78	GeneCards inferred via : Disorders (show sections)

Sources

Variations for Germ Cell Tumor

Sources

Expression for Germ Cell Tumor

Search GEO for disease gene expression data for Germ Cell Tumor.

Sources

Pathways for Germ Cell Tumor

Sources

GO Terms for Germ Cell Tumor

Biological processes related to Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.56	KIT FGFR3
2	phosphorylation	GO:0016310	9.46	STK11 STK10 KIT FGFR3
3	germ cell migration	GO:0008354	9.26	KIT DMRT1
4	protein autophosphorylation	GO:0046777	9.23	STK11 STK10 KIT FGFR3