MCID: GRM002
MIFTS: 39

Germ Cell Tumor

Categories: Cancer diseases, Rare diseases
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Aliases & Classifications for Germ Cell Tumor

MalaCards integrated aliases for Germ Cell Tumor:

Name: Germ Cell Tumor 58 28 16 75

Classifications:



External Ids:

UMLS via Orphanet 72 C0740345
Orphanet 58 ORPHA3399

Summaries for Germ Cell Tumor

MalaCards based summary: Germ Cell Tumor is related to mixed germ cell cancer and testicular germ cell cancer. An important gene associated with Germ Cell Tumor is DMRT1 (Doublesex And Mab-3 Related Transcription Factor 1). The drugs Cisplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include testis, ovary and lymph node, and related phenotype is Increased cell viability after pRB stimulation.

Wikipedia: 75 Germ cell tumor (GCT) is a neoplasm derived from germ cells. Germ-cell tumors can be cancerous or... more...

Related Diseases for Germ Cell Tumor

Diseases related to Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 603)
# Related Disease Score Top Affiliating Genes
1 mixed germ cell cancer 32.7 KIT DMRT1
2 testicular germ cell cancer 32.0 STK11 KIT FGFR3 DMRT1
3 testicular germ cell tumor 31.7 TGCT1 STK11 STK10 KIT FGFR3
4 spermatocytoma 31.4 KIT FGFR3 DMRT1
5 testicular cancer 31.4 STK11 KIT FGFR3 DMRT1
6 gonadoblastoma 30.8 KIT DMRT1
7 ovarian gonadoblastoma 30.2 KIT DMRT1
8 testicular disease 29.9 KIT DMRT1
9 ovarian germ cell cancer 11.9
10 testicular seminoma 11.8
11 malignant pineal area germ cell neoplasm 11.7
12 extragonadal germ cell cancer 11.7
13 nonseminomatous germ cell tumor 11.7
14 testicular germ cell tumor 1 11.7
15 malignant non-dysgerminomatous germ cell tumor of ovary 11.6
16 ovarian mixed germ cell neoplasm 11.6
17 malignant germ cell tumor of the cervix uteri 11.6
18 childhood central nervous system mixed germ cell tumor 11.5
19 central nervous system germ cell tumor 11.5
20 endodermal sinus tumor 11.5
21 childhood testicular germ cell tumor 11.5
22 childhood ovarian germ cell tumor 11.5
23 germ cell cancer 11.5
24 malignant gastric germ cell tumor 11.5
25 adult central nervous system mixed germ cell tumor 11.5
26 malignant germ cell tumor of the vagina 11.5
27 malignant germ cell tumor of the corpus uteri 11.5
28 malignant dysgerminomatous germ cell tumor of the ovary 11.5
29 childhood germ cell cancer 11.5
30 extragonadal nonseminomatous germ cell tumor 11.5
31 malignant cardiac germ cell tumor 11.4
32 ovarian primitive germ cell tumor 11.4
33 polyembryoma 11.4
34 seminoma 11.4
35 pigmented villonodular synovitis 11.4
36 testicular pure germ cell tumor 11.3
37 central nervous system adult germ cell tumor 11.3
38 retroperitoneal germ cell neoplasm 11.3
39 childhood testicular mixed germ cell tumor 11.3
40 malignant childhood germ cell neoplasm 11.3
41 primary germ cell tumor of central nervous system 11.3
42 mixed germ cell tumor of central nervous system 11.3
43 teratocarcinoma 11.3
44 choriocarcinoma 11.3
45 germinoma 11.3
46 childhood cns embryonal cell carcinoma 11.3
47 childhood germ cell brain tumor 11.3
48 gonadal germ cell tumor 11.3
49 dysgerminoma 11.3
50 testicular yolk sac tumor 11.2

Graphical network of the top 20 diseases related to Germ Cell Tumor:



Diseases related to Germ Cell Tumor

Symptoms & Phenotypes for Germ Cell Tumor

GenomeRNAi Phenotypes related to Germ Cell Tumor according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell viability after pRB stimulation GR00230-A-1 8.8 KIT STK10 STK11

Drugs & Therapeutics for Germ Cell Tumor

Drugs for Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 258)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 2767 5702198 441203
2
Etoposide Approved Phase 3 33419-42-0 36462
3
Granisetron Approved, Investigational Phase 3 109889-09-0 3510 5284566
4
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
5
Ofloxacin Approved Phase 3 82419-36-1 4583
6
Coenzyme M Approved, Investigational Phase 3 3375-50-6 598 23662354
7
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
8
Promethazine Approved, Investigational Phase 3 60-87-7 4927
9
Bleomycin Approved, Investigational Phase 3 9041-93-4, 11056-06-7 5360373
10
Ifosfamide Approved Phase 3 3778-73-2 3690
11
Vinblastine Approved Phase 3 865-21-4 241903 13342
12
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
13
Ethinylestradiol Approved Phase 3 57-63-6 5991
14
Polyestradiol phosphate Approved Phase 3 28014-46-2
15
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
16
Moxifloxacin Approved, Investigational Phase 3 186826-86-8, 354812-41-2, 151096-09-2 152946
17
Palifosfamide Investigational Phase 3 31645-39-3 100427
18
Etoposide phosphate Phase 3 16760419
19 Hormones Phase 3
20 Calcium, Dietary Phase 3
21 Cytochrome P-450 Enzyme Inhibitors Phase 3
22 Histamine H2 Antagonists Phase 3
23 Anti-Bacterial Agents Phase 3
24 Anti-Infective Agents Phase 3
25 Estradiol 3-benzoate Phase 3
26 Estradiol 17 beta-cypionate Phase 3
27 Contraceptives, Oral, Combined Phase 3
28 Contraceptives, Oral Phase 3
29 Contraceptive Agents Phase 3
30 Norgestimate, ethinyl estradiol drug combination Phase 3
31
Calcium Nutraceutical Phase 3 7440-70-2 271
32
Magnesium sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9
33
Ranitidine Approved, Withdrawn Phase 1, Phase 2 66357-59-3, 82530-72-1, 66357-35-5 3001055 5039
34
Furosemide Approved, Vet_approved Phase 1, Phase 2 54-31-9 3440
35
Chlorpheniramine Approved Phase 1, Phase 2 113-92-8, 132-22-9 2725
36
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60699 60700
37
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
38
Levoleucovorin Approved, Experimental, Investigational Phase 2 68538-85-2, 58-05-9, 73951-54-9 149436 6006
39
Fluorouracil Approved Phase 2 51-21-8 3385
40
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 11947679 6857599
41
Ondansetron Approved, Withdrawn Phase 2 99614-02-5 4595
42
Sargramostim Approved, Investigational Phase 2 123774-72-1
43
Sunitinib Approved, Investigational Phase 2 557795-19-4 5329102
44
Gemcitabine Approved Phase 2 95058-81-4, 122111-03-9 60750
45
Arsenic trioxide Approved, Investigational Phase 2 1327-53-3 518740
46
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
47
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
48
Darbepoetin alfa Approved, Investigational Phase 2 209810-58-2
49
Alemtuzumab Approved, Investigational Phase 2 216503-57-0
50
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0

Interventional clinical trials:

(show top 50) (show all 248)
# Name Status NCT ID Phase Drugs
1 Randomized Phase II/III Study of Taxol/Paclitaxel-BEP Versus BEP in Patients With Intermediate Prognosis Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Protocol for the Treatment of Extracranial Germ Cell Tumours in Children and Adolescents (GC III) Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
3 Trial of Imaging and Schedule in Seminoma Testis Unknown status NCT00589537 Phase 3
4 Randomized Double-Blind Controlled Phase III Trial of Hyperbaric Oxygen Therapy in Patients Suffering Long-Term Adverse Effects of Radiotherapy for Pelvic Cancer (HOT II) Unknown status NCT01087268 Phase 3
5 A Study to Investigate the Efficacy and Tolerability of Two Dose Levels of Lerisetron Compared With Granisetron in Patients Receiving Radiotherapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
6 A Single Group Trial Evaluating One Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Tumours of the Testis (NSGCTT) Unknown status NCT01726374 Phase 3 BEP(500)
7 A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
8 RANDOMIZED MULTIINSTITUTIONAL PHASE III TRIAL OF BEP AND HIGH DOSE CHEMOTHERAPY VERSUS BEP ALONE IN PREVIOUSLY UNTREATED PATIENTS WITH POOR RISK GERM CELL TUMORS Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
9 A Randomized Phase III Study of Sodium Thiosulfate for the Prevention of Cisplatin-Induced Ototoxicity in Children Completed NCT00716976 Phase 3 sodium thiosulfate
10 A Randomized, Prospective Double-Blind, Placebo-Controlled Trial of Prophylactic Oral Levofloxacin Following Chemotherapy for Lymphoma and Solid Tumors Completed NCT00005590 Phase 3 levofloxacin
11 INTERNATIONAL RANDOMIZED STUDY FOR THE SALVAGE TREATMENT OF GERM CELL TUMOURS Completed NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
12 A Randomized Phase III Toxicity Study of Day 2, 3, 8, 15 Short (30 Minute) Versus Day 1, 2, 3 Long (72 Hours) Infusion Bleomycin for Patients With IGCCCG Good Prognosis Germ Cell Tumors, TE3 Completed NCT00324298 Phase 3 cisplatin;etoposide
13 A Randomized Phase III Study of Sequential High-Dose Cisplatinum/Etoposide/Ifosfamide Plus Stem Cell Support Versus BEP in Patients With Poor Prognosis Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
14 Carboplatin in the Adjuvant Treatment of Stage I Seminoma: A Radomized Comparison of Single Agent Carboplatin With Radiotherapy in the Adjuvant Treatment of Stage I Seminoma of the Testis, Following Orchidectomy Completed NCT00003014 Phase 3 carboplatin
15 A Randomized Double Blinded Trial of Topical Caphosol to Prevent Oral Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
16 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Carboplatin;Cisplatin;Etoposide
17 A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
18 Phase 3 Accelerated BEP: A Randomised Phase 3 Trial of Accelerated Versus Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours Recruiting NCT02582697 Phase 3 Bleomycin (active name: Bleomycin Sulfate);Etoposide;Cisplatin;Pegylated G-CSF (Pegfilgrastim);Filgrastim
19 A Risk-Adapted Strategy of the Use of Dose-Dense Chemotherapy in Patients With Poor-Prognosis Disseminated Non-Seminomatous Germ Cell Tumors Active, not recruiting NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
20 A Randomized Phase III Study of Paclitaxel, Ifosfamide and Cisplatin Versus Vinblastine, Ifosfamide and Cisplatin as Second-Line Therapy for Patients With Relapsed/Resistant Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
21 Randomized, Double Blinded, Placebo-Controlled Trial of Antibacterial Prophylaxis for the Prevention of Bacterial Infections in the Post-Engraftment Phase After Allogeneic Hematopoeitic Stem Cell Transplantation Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
22 Phase I/II Multicentre Trial of Salvage Chemotherapy With Gem-TIP for Relapsed Germ Cell Cancer Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
23 Tandem High-Dose Chemotherapy (HDCT) With Peripheral-Blood Stem-Cell Rescue for Patients With Metastatic Germ-Cell Tumors Failing First-Line Treatment Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
24 Clinical Correlative Studies In Primary Central Nervous System Germ Cell Tumors: The Third International CNS Germ Cell Tumor Study Group Protocol Unknown status NCT00025324 Phase 2 carboplatin;cyclophosphamide;etoposide;thiotepa
25 Salvage Chemotherapy for Poor Prognosis Germ Cell Tumors - A Phase I-II Sequential Chemotherapy Protocol of Bevacizumab (Avastin) Plus High-dose ICE (Ifosfamide - Carboplatin - Etoposide) Intensification Unknown status NCT01966913 Phase 1, Phase 2 Bevacizumab;ICE chemotherapy regimen
26 High-Dose Chemotherapy With Tandem Peripheral Blood Stem Cell (PBSC) Rescue for the Treatment of High-Risk Pediatric Solid Tumors. Unknown status NCT00179816 Phase 1, Phase 2 High-Dose Chemotherapy with Tandem PBSC Rescue.
27 A Prospective Multicenter Phase II Trial of Gemcitabine, Cisplatin, and Ifosfamide (GIP) in Patients With Relapsed Non-Seminomatous Germ-Cell Tumors (NSGCT) and a Predicted Favorable Prognosis Unknown status NCT00127049 Phase 2 gemcitabine, ifosfamide, cisplatin, G-CSF
28 Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer Completed NCT01037790 Phase 2 PD-0332991
29 Psychosexual Intervention for Gynecologic and Breast Cancer Patients Completed NCT01764802 Phase 2
30 Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors With Paclitaxel, Ifosfamide and Carboplatin Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
31 A Non-randomized Phase 2 Study of Alvocidib (Flavopiridol) Plus Oxaliplatin With or Without 5-FU and Leucovorin for Relapsed or Refractory Germ-Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
32 A Phase II Study of Oxaliplatin in Children With Recurrent Solid Tumors Completed NCT00091182 Phase 2 oxaliplatin
33 Prevention of DMSO-Related Nausea and Vomiting by Prophylactic Administration of Ondansetron for Patients Receiving Autologous Cryopreserved Peripheral Blood Stem Cells Completed NCT00795769 Phase 2 ondansetron
34 Myeloablative Chemotherapy With Bone Marrow Rescue For Rare Poor-Prognosis Cancers Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
35 A Prospective Evaluation of a Palliative Radio-Surgical Approach for the Treatment of Gynecologic Malignancies Completed NCT01079832 Phase 2
36 High-Dose Thiotepa With Autologous Stem Cell Rescue in Patients With Malignancies Refractory to Conventional Chemotherapy Completed NCT00003173 Phase 2 thiotepa
37 Accelerated BEP Chemotherapy for Intermediate and High Risk Metastatic Germ Cell Tumor Completed NCT00453232 Phase 2 cisplatin;etoposide
38 Phase II Trial of Paclitaxel, Ifosfamide, and Cisplatin in Previously Untreated Intermediate and Poor Risk Germ Cell Tumor Patients Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
39 A Phase II Study of Sunitinib in Patients With Refractory or Relapsed Germ Cell Tumors Completed NCT00453310 Phase 2 sunitinib malate
40 Phase I/II Trial of Sequential Paclitaxel/Ifosfamide Followed by Dose-Escalated, Dose-Intensive Carboplatin, Paclitaxel and Ifosfamide With Stem Cell Support in Cisplatin-Resistant Germ Cell Tumor Patients Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
41 Phase II Study Of Arsenic Trioxide In Patients With Refractory Germ Cell Malignancies Completed NCT00036842 Phase 2 arsenic trioxide
42 Phase II Study of Arsenic Trioxide in Neuroblastoma and Other Pediatric Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
43 High Dose Carboplatin, Etoposide, Cyclophosphamide and Autologous Bone Marrow Transplantation for Relapsed and Refractory Germ Cell Cancer: A Phase II Pilot Study Completed NCT00002943 Phase 2 carboplatin;cyclophosphamide;etoposide
44 Tandem High-Dose Chemotherapy With Autologous Stem Cell Rescue for Poor-Prognosis Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
45 PHASE II TRIAL WITH DOCETAXEL IN PATIENTS WITH RELAPSING GERM CELL CANCER Completed NCT00002903 Phase 2 docetaxel
46 A Phase II Study of BMS-247550 In Advanced Germ Cell Tumor Patients - THERAPEUTIC/DIAGNOSTIC PROTOCOL Completed NCT00070096 Phase 2 ixabepilone
47 High-Dose Cisplatin, Etoposide and Bleomycin (HD-PEB) Combined With Amifostine in Children With High-Risk Malignant Germ Cell Tumors - A POG Pilot Study Completed NCT00003811 Phase 2 amifostine trihydrate;cisplatin;etoposide
48 PHASE I/II TRIAL OF SEQUENTIAL TAXOL/IFOSFAMIDE AND DOSEINTENSIVE CARBOPLATIN/ETOPOSIDE WITH STEM CELL SUPPORT IN CISPLATIN-RESISTANT GERM CELL TUMOR PATIENTS WITH UNFAVORABLE PROGNOSTIC FEATURES Completed NCT00002558 Phase 1, Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
49 INTENSIVE CHEMOTHERAPY FOR RELAPSED OR REFRACTORY GERM CELL TUMORS EMPLOYING HIGH-DOSE CARBOPLATIN, ETOPOSIDE, AND THIOTEPA WITH AUTOLOGOUS BONE MARROW RESCUE FOR PATIENTS 15 TO 60 YEARS OF AGE Completed NCT00002508 Phase 1, Phase 2 carboplatin;etoposide
50 High Dose Ifosfamide, Carboplatin and Etoposide With Amifostine Chemoprotection Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide

Search NIH Clinical Center for Germ Cell Tumor

Genetic Tests for Germ Cell Tumor

Genetic tests related to Germ Cell Tumor:

# Genetic test Affiliating Genes
1 Germ Cell Tumor 28

Anatomical Context for Germ Cell Tumor

Organs/tissues related to Germ Cell Tumor:

MalaCards : Testis, Ovary, Lymph Node, T Cells, Bone Marrow, Brain, Spinal Cord

Publications for Germ Cell Tumor

Articles related to Germ Cell Tumor:

(show top 50) (show all 4121)
# Title Authors PMID Year
1
Lost in descent: Complications of cryptorchidism. 62
36345463 2023
2
Relationship between the timing of chemotherapy and surgical complications following surgical biopsy in children with malignant solid tumors. 62
36184783 2023
3
A case of germinoma located in the fornix inducing transsynaptic atrophy of the Papez circuit. 62
36425391 2023
4
Oxaliplatin related multiple focal nodular hyperplasia mimicking metastasis from a gastric cancer. 62
35225712 2022
5
First-line salvage treatment options for germ cell tumor patients failing stage-adapted primary treatment : A comprehensive review compiled by the German Testicular Cancer Study Group. 62
35226138 2022
6
Feasibility of treating pediatric intracranial germ cell tumors in a middle-income country: The Jordanian experience. 62
36131594 2022
7
High prevalence of overweight/obesity and dyslipidemia in patients with intracranial germ cell tumors. 62
36088446 2022
8
Endodermal sinus tumor with pancreatic origin: A case report. 62
36413894 2022
9
Role of Lactate Dehydrogenase in Identifying Relapse for Patients With Stage I Testicular Cancer on Surveillance. 62
35997696 2022
10
[Multimodal treatment of testicular cancer: chemotherapy, surgery or radiotherapy?] 62
36224397 2022
11
A curious case of ovarian cysts. 62
36412944 2022
12
Familial Male-limited Precocious Puberty (FMPP) and Testicular Germ Cell Tumors. 62
36071555 2022
13
Split-Tendon Medial Transposition of Lateral Rectus for Pediatric Complete Oculomotor Palsy. 62
36342135 2022
14
A Prospective Evaluation of Fatigue in Pediatric Brain Tumor Patients Treated With Radiation Therapy. 62
36285825 2022
15
Atypical cartilage in type II germ cell tumors of the mediastinum show significantly different patterns of IDH1/2 mutations from conventional chondrosarcoma. 62
35660795 2022
16
Testis-expressed gene 11 inhibits cisplatin-induced DNA damage and contributes to chemoresistance in testicular germ cell tumor. 62
36319719 2022
17
Testis-sparing Surgery in Adult Patients with Germ Cell Tumors: Systematic Search of the Literature and Focused Review. 62
36418210 2022
18
Robotic post-chemotherapy retroperitoneal lymph node dissection for testicular cancer: A multicenter collaborative study. 62
36437156 2022
19
Anesthesia for mandibular yolk sac tumor in children after radiotherapy and chemotherapy: A case report. 62
36408079 2022
20
Primary Retroperitoneal Lymph Node Dissection for Patients With Pathologic Stage II Nonseminomatous Germ Cell Tumor-N1, N2, and N3 Disease: Is Adjuvant Chemotherapy Necessary? 62
35675585 2022
21
Growing teratoma syndrome - ovarian germ cell tumor. 62
36347301 2022
22
A comprehensive evaluation of sexual and reproductive outcomes following robot-assisted retroperitoneal lymph node dissection for nonseminomatous germ cell tumor. 62
35381697 2022
23
Endoscopic aqueductal membrane fenestration was effective for intractable hydrocephalus after removal of a nongerminomatous germ cell tumor exhibiting growing teratoma syndrome: a case report. 62
36443673 2022
24
Burned-out germ cell tumor presenting with acute abdomen. 62
36282162 2022
25
Spontaneous rupture of a retroperitoneal lymph node metastasis causing massive hemorrhage in a patient with advanced mixed germ cell tumor. 62
35968525 2022
26
Case Report: A Giant Epignathus with a Well-Developed Skeleton of Head and Neck. 62
36412010 2022
27
Effect of the PARP inhibitor veliparib on germ cell tumor cell lines. 62
36276487 2022
28
CNS non-germinomatous germ cell tumor (NGGCT): Lessons from the recent past. 62
35512703 2022
29
Expanded endoscopic endonasal transtuberculum approach for resection of Germ cell tumor. 62
36427692 2022
30
Isolated corpora cavernosa germ cell tumor metastasis requiring complex excision and reconstruction. 62
36281436 2022
31
Germ cell tumor with duodenal involvement: a rare case of gastrointestinal bleeding. 62
36412989 2022
32
Metastatic germ cell tumor in ascitic effusion cytology- Is it that uncommon? 62
36308413 2022
33
Reply to Alireza Ghoreifi and Hooman Djaladat's Letter to the Editor re: Isamu Tachibana, Sean Q. Kern, Antoin Douglawi, et al. Primary Retroperitoneal Lymph Node Dissection for Patients with Pathologic Stage II Nonseminomatous Germ Cell Tumor-N1, N2, and N3 Disease: Is Adjuvant Chemotherapy Necessary? J Clin Oncol. In press. https://doi.org/10.1200/JCO.22.00118: Is Retroperitoneal Lymph Node Dissection Without Adjuvant Chemotherapy Enough for All Patients with Pathologic Stage II Nonseminoma Germ Cell Tumor? 62
36195478 2022
34
Re: Isamu Tachibana, Sean Q. Kern, Antoin Douglawi, et al. Primary Retroperitoneal Lymph Node Dissection for Patients with Pathologic Stage II Nonseminomatous Germ Cell Tumor-N1, N2, and N3 Disease: Is Adjuvant Chemotherapy Necessary? J Clin Oncol. In press. https://doi.org/10.1200/JCO.22.00118: Is Retroperitoneal Lymph Node Dissection Without Adjuvant Chemotherapy Enough for All Patients with Pathologic Stage II Nonseminoma Germ Cell Tumor? 62
36195480 2022
35
[Expert consensus on specimen handling and pathological diagnosis of germ cell tumor of testis]. 62
36207904 2022
36
Precocious puberty due to intracranial germ cell tumors: a case-control study. 62
35938923 2022
37
Updates in 2022 on the staging of testicular germ cell tumors. 62
35926809 2022
38
18F-FDG PET/CT Showing Rare Mediastinal Growing Teratoma Syndrome Following Chemotherapy. 62
36268930 2022
39
DUSP5 and PHLDA1 mutations in mature cystic teratomas of the ovary identified on whole-exome sequencing may explain teratoma characteristics. 62
36289533 2022
40
Posterior mediastinal teratoma presenting as an abdominal mass in a child: A case report. 62
35965932 2022
41
Applications of the Grading Scales for the Detection of Ototoxicity in Children after Treatment of Neuroblastoma and Extracranial Germinal Tumor. 62
36191558 2022
42
Phase II study of Disulfiram and Cisplatin in Refractory Germ Cell Tumors. The GCT-SK-006 phase II trial. 62
35763178 2022
43
Accuracy of germ cell tumor histology and stage within a Canadian cancer registry. 62
36218319 2022
44
Evaluation of miR-371a-3p to predict viable germ cell tumor in patients with pure seminoma receiving retroperitoneal lymph node dissection. 62
36254623 2022
45
[Analysis of 42 cases of childhood superior vena cava syndrome associated with mediastinal malignancy]. 62
36207849 2022
46
All pineal tumors expressing germ cell tumor markers are not necessarily germ cell tumors: histopathological and molecular study of a midline primary intracranial sarcoma DICER1-mutant. 62
36307659 2022
47
Primary vaginal endodermal sinus tumor in infants and children: experience from a tertiary center. 62
36207682 2022
48
Ruptured dermoid cyst of ovary developing into chronic peritonitis; a rare complication diagnosed by contrast CT: A case study. 62
36268424 2022
49
Somatic-type malignancies in testicular germ cell tumors. 62
35803413 2022
50
[Genetic analysis and pathological features of one 46,XX testicular disorder of sex development cases with prostate germ cell tumor]. 62
36082576 2022

Variations for Germ Cell Tumor

Expression for Germ Cell Tumor

Search GEO for disease gene expression data for Germ Cell Tumor.

Pathways for Germ Cell Tumor

GO Terms for Germ Cell Tumor

Biological processes related to Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.56 KIT FGFR3
2 phosphorylation GO:0016310 9.46 STK11 STK10 KIT FGFR3
3 germ cell migration GO:0008354 9.26 KIT DMRT1
4 protein autophosphorylation GO:0046777 9.23 STK11 STK10 KIT FGFR3

Molecular functions related to Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.26 STK11 STK10 KIT FGFR3
2 protein kinase activity GO:0004672 8.92 STK11 STK10 KIT FGFR3

Sources for Germ Cell Tumor

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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