Aliases & Classifications for Germinoma

MalaCards integrated aliases for Germinoma:

Name: Germinoma 12 56 6 45 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3304
MeSH 45 D018237
NCIt 51 C3753
SNOMED-CT 69 28307001
UMLS 74 C0206660

Summaries for Germinoma

Disease Ontology : 12 A germ cell cancer that lacks histologic differentiation. It usually refers to a tumor in the brain.

MalaCards based summary : Germinoma is related to central nervous system germinoma and brain germinoma. An important gene associated with Germinoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Peptide hormone metabolism and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Mechlorethamine and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include pineal, brain and spinal cord, and related phenotypes are endocrine/exocrine gland and liver/biliary system

Wikipedia : 77 A germinoma is a type of germ-cell tumor, which is not differentiated upon examination. It may be benign... more...

Related Diseases for Germinoma

Diseases related to Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 central nervous system germinoma 33.6 ALPP AVP POU5F1
2 brain germinoma 33.6 AFP AVP POU5F1
3 diabetes insipidus 30.7 AVP PRL
4 seminoma 30.6 AFP ALPP CGA CGB3 INHA KIT
5 mature teratoma 30.6 AFP POU5F1
6 testicular seminoma 30.5 AFP CGA CGB3
7 embryonal testis carcinoma 30.2 AFP POU5F1
8 choriocarcinoma 30.0 ALPP CGA CGB3
9 embryonal carcinoma 30.0 AFP KIT POU5F1
10 gonadoblastoma 30.0 ALPP KIT
11 teratoma 30.0 AFP CGA CGB3 KIT POU5F1
12 dysgerminoma 29.8 AFP ALPP KIT
13 mixed germ cell tumor 29.7 AFP CGA CGB3 KIT
14 pituitary hormone deficiency, combined, 2 29.7 AVP PRL
15 testicular cancer 29.6 AFP ALPP CGA CGB3
16 childhood brain germinoma 12.4
17 pineal region germinoma 12.3
18 extragonadal germinoma 12.1
19 adult central nervous system germinoma 12.1
20 childhood central nervous system germinoma 12.1
21 malignant pineal area germ cell neoplasm 11.2
22 extragonadal germ cell cancer 10.3 AFP POU5F1
23 ovarian embryonal carcinoma 10.3 AFP POU5F1
24 endodermal sinus tumor 10.3 AFP CGB3
25 testicular malignant germ cell cancer 10.3 AFP ALPP
26 ovarian mixed germ cell neoplasm 10.3 AFP CGA
27 polyembryoma 10.3 AFP CGA
28 sacrococcygeal teratoma 10.3 AFP CGA
29 triploidy 10.3 AFP CGA
30 pineoblastoma 10.3 AFP POU5F1
31 mixed germ cell cancer 10.3 AFP POU5F1
32 hydrocele 10.2 AFP CGA
33 precocious puberty 10.2
34 germ cell and embryonal cancer 10.2 AFP POU5F1
35 hydatidiform mole, recurrent, 1 10.2 CGA CGB3
36 ovarian cyst 10.2 AFP PRL
37 oculomotor nerve paralysis 10.2 AFP AVP
38 third cranial nerve disease 10.2 AFP AVP
39 germ cells tumors 10.2
40 testicular leydig cell tumor 10.2 CGB3 CYP21A2
41 leydig cell tumor 10.2 AFP CYP21A2
42 lymphocytic hypophysitis 10.2
43 testicular yolk sac tumor 10.2 AFP POU5F1
44 luteoma 10.2 CGA CYP21A2
45 hepatic angiomyolipoma 10.2 AFP KIT
46 sarcomatoid renal cell carcinoma 10.2 CGB3 KIT
47 endometrial small cell carcinoma 10.2 AFP KIT
48 intermittent explosive disorder 10.2 CGA PRL
49 rete testis adenocarcinoma 10.1 AFP KIT
50 mediastinal cancer 10.1 AFP KIT

Graphical network of the top 20 diseases related to Germinoma:



Diseases related to Germinoma

Symptoms & Phenotypes for Germinoma

MGI Mouse Phenotypes related to Germinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 AFP CGA INHA KIT POU5F1 PRL
2 liver/biliary system MP:0005370 9.35 AFP INHA KIT POU5F1 PRL
3 reproductive system MP:0005389 9.1 AFP CGA INHA KIT POU5F1 PRL

Drugs & Therapeutics for Germinoma

Drugs for Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 195)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 51-75-2 4033
2
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 38904 10339178 498142
3
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1 3778-73-2 3690
4
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
5
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 441203 84093 2767
6 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
7 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1
8 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1
9
Isophosphamide mustard Phase 4,Phase 3,Phase 2,Phase 1 0
10 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1
11 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1
12
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
13
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 6055-19-2, 50-18-0 2907
14
Bleomycin Approved, Investigational Phase 3,Phase 2 11056-06-7 5360373
15
Sargramostim Approved, Investigational Phase 3,Phase 2,Phase 1 123774-72-1, 83869-56-1
16
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
17
Ondansetron Approved Phase 3,Phase 2 99614-02-5 4595
18
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1 1177-87-3
19
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
20
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
21
Mesna Approved, Investigational Phase 3 3375-50-6 598
22
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
23
Promethazine Approved, Investigational Phase 3 60-87-7 4927
24 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
25 Antiemetics Phase 3,Phase 2,Phase 1
26 Serotonin Antagonists Phase 3,Phase 2
27 Autonomic Agents Phase 3,Phase 2,Phase 1
28 Serotonin Agents Phase 3,Phase 2
29 Neurotransmitter Agents Phase 3,Phase 2,Early Phase 1
30 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
31 Immunologic Factors Phase 3,Phase 2,Phase 1
32 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
33 Antirheumatic Agents Phase 3,Phase 2,Phase 1
34 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
35 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
36 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
37 Emetics Phase 3
38 BB 1101 Phase 3,Phase 1
39 Antimitotic Agents Phase 3,Phase 2,Phase 1
40 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
41 Histamine H2 Antagonists Phase 3
42
Serotonin Investigational, Nutraceutical Phase 3,Phase 2 50-67-9 5202
43
Sirolimus Approved, Investigational Phase 2,Phase 1 53123-88-9 46835353 6436030 5284616
44
Everolimus Approved Phase 2,Phase 1 159351-69-6 6442177 70789204
45
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
46
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
47
Darbepoetin alfa Approved, Investigational Phase 2 11096-26-7, 209810-58-2
48
Thiotepa Approved, Investigational Phase 2,Phase 1 52-24-4 5453
49
Levoleucovorin Approved, Investigational Phase 2,Phase 1 68538-85-2
50
Fluorouracil Approved Phase 2,Phase 1 51-21-8 3385

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors Unknown status NCT01424839 Phase 4 Carboplatin, Etoposide, Ifosfamide;Cisplatin, etoposide, Ifosfamide (standard);Cisplatin, Etoposide, Ifosfamide (high dose)
2 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
3 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
4 Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor Completed NCT00085098 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
5 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
6 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
7 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
8 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
9 Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer Recruiting NCT02341989 Phase 3 Bleomycin Etoposide and Cisplatin;Carboplatin
10 Chemotherapy Plus Reduced Radiotherapy in Intracranial Germinoma Unknown status NCT02782754 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin
11 Proton Radiotherapy for Stage I, IIA, and IIB Seminoma Unknown status NCT01557790 Phase 2
12 Everolimus and Letrozole in Treating Patients With Recurrent Hormone Receptor Positive Ovarian, Fallopian Tube, or Primary Peritoneal Cavity Cancer Unknown status NCT02283658 Phase 2 Everolimus;Letrozole
13 ARQ 197 for Subjects With Relapsed or Refractory Germ Cell Tumors Completed NCT01055067 Phase 2 Tivantinib (ARQ 197)
14 Darbepoetin Alfa in Patients With "Poor Prognosis" Germ Cell Tumor Treated With High-Dose Chemotherapy (HD-VIP) Completed NCT00204633 Phase 2 Darbepoetin alfa
15 Carboplatin AUC-10 With Early PET Scanning in Metastatic Seminoma Completed NCT02272816 Phase 2 Carboplatin AUC-10
16 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
17 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
18 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors Completed NCT00957905 Phase 2 Alvocidib Hydrochloride;Fluorouracil;Leucovorin Calcium;Oxaliplatin
19 Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer Completed NCT01764802 Phase 2
20 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
21 Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies Completed NCT01079832 Phase 2
22 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2 ondansetron
23 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
24 Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx) Recruiting NCT01270724 Phase 2 Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx).
25 Therapeutic Strategy Guided by PET-TDM for Patients With Seminoma Recruiting NCT01887340 Phase 2 Carboplatin;Etoposide;Cisplatin
26 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
27 Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Recruiting NCT02122185 Phase 2 metformin hydrochloride;placebo;Chemotherapy
28 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
29 Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Active, not recruiting NCT01602666 Phase 2 Carboplatin;Etoposide;Ifosfamide
30 Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas Active, not recruiting NCT01966809 Phase 2 Photofrin photodynamic therapy.
31 Therapy De-escalation in Seminoma Stage IIA/B Active, not recruiting NCT01593241 Phase 2 Carboplatin
32 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
33 Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors Active, not recruiting NCT03158064 Phase 2 Durvalumab;Tremelimumab
34 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
35 Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage II or Stage III Testicular or Ovarian Cancer Terminated NCT00042952 Phase 2 imatinib mesylate
36 Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload Terminated NCT01159067 Phase 2 deferasirox
37 Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
38 Sunitinib in Treating Young Patients With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
39 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
40 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
41 Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00929903 Phase 1 pazopanib hydrochloride
42 Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors Completed NCT01682746 Phase 1 Photofrin (porfimer sodium) & photodynamic therapy.
43 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
44 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
45 Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors Completed NCT00003141 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;thiotepa;vincristine sulfate
46 Carboplatin, Gemcitabine Hydrochloride, and Stereotactic Body Radiation Therapy in Gynecological Cancer Completed NCT01652794 Phase 1 carboplatin;gemcitabine hydrochloride
47 Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia Completed NCT01484015 Phase 1 cefepime hydrochloride
48 Temsirolimus and Vinorelbine Ditartrate in Treating Patients With Unresectable or Metastatic Solid Tumors Completed NCT01155258 Phase 1 temsirolimus;vinorelbine ditartrate
49 Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors Completed NCT01131234 Phase 1 Gamma-Secretase Inhibitor RO4929097;Cediranib Maleate
50 Temsirolimus, Carboplatin, and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00408655 Phase 1 paclitaxel;carboplatin;temsirolimus

Search NIH Clinical Center for Germinoma

Cochrane evidence based reviews: germinoma

Genetic Tests for Germinoma

Anatomical Context for Germinoma

MalaCards organs/tissues related to Germinoma:

42
Pineal, Brain, Spinal Cord, Breast, Lung, Pituitary, T Cells

Publications for Germinoma

Articles related to Germinoma:

(show top 50) (show all 628)
# Title Authors Year
1
Germinoma Involving the Retina: An Unusual Presentation of Recurrent Intracranial Mixed Germ Cell Tumor. ( 30630044 )
2019
2
Ectopic germinoma in the corpus callosum with severe restrictive anorexia: case report and review of literature. ( 30682514 )
2019
3
Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome. ( 30738016 )
2019
4
Primary cavernous sinus germinoma with atypical extension pattern: a case report and review of the literature. ( 30796559 )
2019
5
Early diagnosis in a case of atypically located germinoma: 1H-MR-spectroscopy as a decision tool. ( 30834129 )
2019
6
Pontomedullary germinoma with suprasellar and spinal metastasis: A report and comprehensive review of literature. ( 30860147 )
2019
7
Bifocal germinoma of the septum pellucidum and the sellar-supra-sellar region: An uncommon presentation for a rare tumor. ( 30886913 )
2019
8
A Craniopharyngioma Associated With Elevated Cerebrospinal Fluid HCG Concentrations Misdiagnosed as a Germinoma. ( 29963005 )
2018
9
Intracranial germinoma causing cerebral haemiatrophy and hypopituitarism. ( 29378909 )
2018
10
Unusual presentation of epilepsy of germinoma located in the frontal-lobe: case report and literature review. ( 30450984 )
2018
11
Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report. ( 30392398 )
2018
12
Secondary glioblastoma after treatment of intracranial germinoma - would radiation-only therapy still be safe? Case report. ( 30445947 )
2018
13
Fast-developing fatal diffuse leptomeningeal dissemination of a pineal germinoma in a young child: a case report and literature review. ( 30451003 )
2018
14
Bromocriptine-responsive supersellar germinoma with the expression of dopamine receptors: A case report. ( 30476699 )
2018
15
A Rare Localized Pituitary Stalk Germinoma Presenting in the Third Decade. ( 30647977 )
2018
16
Pineal granuloma masking a germinoma: do not hesitate to repeat the biopsy. ( 27654456 )
2018
17
Identification of characteristic features of pineal germinoma that enhance accuracy of preoperative differentiation in pineal region tumors: its significance on optimum surgical treatment. ( 28247123 )
2018
18
Significance of human chorionic gonadotropin as a predictor of resistance to standard chemo-radiotherapy for pure germinoma. ( 28819802 )
2018
19
Practice patterns and survival outcomes of intracranial germinoma: an analysis of the National Cancer Database. ( 29177595 )
2018
20
Paraneoplastic Optic Neuropathy and Pineal Germinoma With Collapsin Response-Mediating Protein Antibodies. ( 29266032 )
2018
21
PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes. ( 29617441 )
2018
22
Capsuloganglionic Germinoma: A Rare Site for Uncommon Childhood Tumor. ( 29682070 )
2018
23
High-dose chemotherapy with autologous stem cell transplantation spares re-irradiation for recurrent intracranial germinoma. ( 29693779 )
2018
24
Unilateral paraneoplastic optic disc edema and retinal periphlebitis in pineal germinoma. ( 29780941 )
2018
25
Thalamic germinoma: a challenging diagnosis, case report and literature review. ( 29992007 )
2018
26
A case of bilateral vasculitis associated with pineal germinoma. ( 30094391 )
2018
27
Treatment outcomes of intracranial germinoma: a retrospective analysis of 170 patients from a single institution. ( 30209611 )
2018
28
Clinical case seminar: Familial intracranial germinoma. ( 30379323 )
2018
29
Pineal and Suprasellar Germinoma Cooccurence with Vertebra Plana: A Case Report. ( 30381920 )
2018
30
Suprasellar Germinoma Presenting with Slipped Capital Femoral Epiphysis: Case Report. ( 29487768 )
2017
31
Hypothalamic-pituitary germinoma presenting as generalized hypohidrosis. ( 28202423 )
2017
32
Mixed Gonadal Germ Cell Tumor Composed of a Spermatocytic Tumor-Like Component and Germinoma Arising in Gonadoblastoma in a Phenotypic Woman With a 46, XX Peripheral Karyotype: Report of the First Case. ( 28614211 )
2017
33
Mixed pineal mature teratoma and germinoma in two brothers of the fraternal triplets. ( 28236067 )
2017
34
Primary Mediastinal Pure Seminomatous Germ Cell Tumor (Germinoma) as a Rare Cause of Precocious Puberty in a 9 Year-Old Patient. ( 28888750 )
2017
35
Adipsic diabetes insipidus revealing a bifocal intracranial germinoma. ( 28483362 )
2017
36
Efficacy of Ifosfamide-Cisplatin-Etoposide (ICE) Chemotherapy for a CNS Germinoma in a Child With Down Syndrome. ( 27879538 )
2017
37
Primary extramedullary spinal germinoma: case report and review of the literature. ( 27822593 )
2017
38
Perifocal Inflammatory Reaction with Volume Fluctuation Caused by Diagnostic Radiation-Induced Regression in Germinoma Makes Histological Diagnosis Difficult despite Its Disappearance following Treatment: A Significant Pitfall and Countermeasures to It. ( 27832656 )
2017
39
Primary Germinoma Originating from the Insular Lobe: A Case Report and Review of the Literature. ( 28007604 )
2017
40
Atypical major depressive episode as initial presentation of intracranial germinoma in a male adolescent. ( 28053535 )
2017
41
Anomalous intracranial germinoma with unilateral cerebral peduncle swelling. ( 28283777 )
2017
42
Progressive hemiparesis in a young man: Hemicerebral atrophy as the initial manifestation of basal ganglia germinoma. ( 28413537 )
2017
43
Holmes' tremor secondary to a posterior third ventricular germinoma: a rare case report. ( 28470382 )
2017
44
Successful Treatment of Pituitary Germinoma with Etoposide, Cisplatin, Vincristine, Methotrexate and Bleomycin Chemotherapy Without Radiotherapy. ( 28551652 )
2017
45
Radiotherapy and chemotherapy plus radiation in the treatment of patients with pure intracranial germinoma: A meta-analysis. ( 28602629 )
2017
46
Intracranial Germinoma: Systemic Chemotherapy in Addition to Dose-Reduced Radiation Therapy. ( 28614087 )
2017
47
A rare case report and literatures review on primary germinoma in cerebellar hemisphere. ( 28689343 )
2017
48
Pediatric intracranial germinoma: use chemotherapy first. ( 29044451 )
2017
49
Cerebral germinoma revealed through a polydipsic polyuric syndrome in a 10-year-old girl: case report. ( 29232188 )
2017
50
Brain dose-sparing radiotherapy techniques for localized intracranial germinoma: Case report and literature review of modern irradiation. ( 27080575 )
2016

Variations for Germinoma

ClinVar genetic disease variations for Germinoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PMS2 NM_000535.5(PMS2): c.2174C> T (p.Ala725Val) single nucleotide variant Uncertain significance rs150630090 GRCh37 Chromosome 7, 6022455: 6022455
2 PMS2 NM_000535.5(PMS2): c.2174C> T (p.Ala725Val) single nucleotide variant Uncertain significance rs150630090 GRCh38 Chromosome 7, 5982824: 5982824
3 PTCH1 NM_000264.4(PTCH1): c.1234G> A (p.Ala412Thr) single nucleotide variant Uncertain significance rs370354759 GRCh37 Chromosome 9, 98240450: 98240450
4 PTCH1 NM_000264.4(PTCH1): c.1234G> A (p.Ala412Thr) single nucleotide variant Uncertain significance rs370354759 GRCh38 Chromosome 9, 95478168: 95478168
5 PAX5 NM_016734.3(PAX5): c.1169G> A (p.Arg390His) single nucleotide variant Uncertain significance GRCh38 Chromosome 9, 36840567: 36840567
6 PAX5 NM_016734.3(PAX5): c.1169G> A (p.Arg390His) single nucleotide variant Uncertain significance GRCh37 Chromosome 9, 36840564: 36840564

Expression for Germinoma

Search GEO for disease gene expression data for Germinoma.

GO Terms for Germinoma

Cellular components related to Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 AFP AVP CGA CGB3 INHA PRL
2 extracellular space GO:0005615 9.17 AFP AVP CGA CGB3 INHA KIT

Biological processes related to Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.5 AVP CGB3 INHA
2 SMAD protein signal transduction GO:0060395 9.48 AFP INHA
3 somatic stem cell population maintenance GO:0035019 9.46 KIT POU5F1
4 positive regulation of cell proliferation GO:0008284 9.46 AVP CGA KIT PRL
5 erythrocyte differentiation GO:0030218 9.4 INHA KIT
6 ovarian follicle development GO:0001541 9.37 INHA KIT
7 positive regulation of JAK-STAT cascade GO:0046427 9.26 KIT PRL
8 cellular response to hormone stimulus GO:0032870 9.13 CGA
9 regulation of signaling receptor activity GO:0010469 9.02 AVP CGA CGB3 INHA PRL
10 peptide hormone processing GO:0016486 8.96 CGA CGB3

Molecular functions related to Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.02 AVP CGA CGB3 INHA PRL
2 cytokine binding GO:0019955 8.96 KIT POU5F1

Sources for Germinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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