MCID: GST052
MIFTS: 39

Gestational Choriocarcinoma

Categories: Cancer diseases, Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Gestational Choriocarcinoma

MalaCards integrated aliases for Gestational Choriocarcinoma:

Name: Gestational Choriocarcinoma 12 58 15 71
Molar Pregnancy with Choriocarcinoma 12
Gestational Chorionepithelioma 12

Characteristics:

Orphanet epidemiological data:

58
gestational choriocarcinoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:2025
NCIt 49 C4646
SNOMED-CT 67 1884006
ICD10 via Orphanet 33 C58
UMLS via Orphanet 72 C0349557
Orphanet 58 ORPHA99926
UMLS 71 C0349557

Summaries for Gestational Choriocarcinoma

Disease Ontology : 12 A choriocarcicoma that develops in the presence of a preceding gestational event.

MalaCards based summary : Gestational Choriocarcinoma, also known as molar pregnancy with choriocarcinoma, is related to non-gestational choriocarcinoma and gestational trophoblastic neoplasm. An important gene associated with Gestational Choriocarcinoma is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways is NRF2 pathway. The drugs Methotrexate and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include ovary, placenta and brain, and related phenotypes are choriocarcinoma and metrorrhagia

Related Diseases for Gestational Choriocarcinoma

Diseases related to Gestational Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 non-gestational choriocarcinoma 34.5 CSH2 CSH1
2 gestational trophoblastic neoplasm 32.7 NLRP7 H19 CSH2 CSH1
3 choriocarcinoma 32.1 SLC6A4 HLA-G H19 ENPEP CSH2 CSH1
4 choriocarcinoma of ovary 30.9 CSH2 CSH1
5 trophoblastic neoplasm 30.8 H19 CSH2 CSH1
6 hydatidiform mole, recurrent, 1 30.7 NLRP7 H19
7 gestational ovarian choriocarcinoma 30.5 CSH2 CSH1
8 fallopian tube gestational choriocarcinoma 12.8
9 primary non-gestational choriocarcinoma of ovary 12.4
10 placental choriocarcinoma 11.7
11 recurrent hydatidiform mole 11.4
12 gestational uterine corpus choriocarcinoma 11.4
13 ectopic pregnancy 10.6
14 testicular trophoblastic tumor 10.4 CSH2 CSH1
15 choriocarcinoma of the testis 10.4 CSH2 CSH1
16 non-gestational ovarian choriocarcinoma 10.4 CSH2 CSH1
17 invasive mole 10.4
18 rh isoimmunization 10.4 CSH2 CSH1
19 corpus luteum cyst 10.4 CSH2 CSH1
20 epithelioid trophoblastic tumor 10.3 CSH2 CSH1
21 endometrial cancer 10.3
22 atrial septal defect 4 10.3 H19 ENPEP
23 supine hypotensive syndrome 10.3 CSH2 CSH1
24 cockayne syndrome b 10.2 CSH2 CSH1
25 adenocarcinoma 10.2
26 amenorrhea 10.2
27 placental site trophoblastic tumor 10.2 CSH2 CSH1
28 placenta disease 10.2 HLA-G CSH2 CSH1
29 peritonitis 10.1
30 graves disease 1 10.1
31 persistent fetal circulation syndrome 10.0 HLA-G CSH2 CSH1 ABCG2
32 microscopic colitis 9.9 SLC6A4 IFNG
33 rare tumor 9.9
34 partial hydatidiform mole 9.9
35 cerebral aneurysms 9.9
36 aneurysm 9.9
37 germ cells tumors 9.9
38 chromosomal triplication 9.9
39 alopecia 9.9
40 acute cor pulmonale 9.9
41 hyperthyroidism 9.9
42 active peptic ulcer disease 9.9
43 malignant teratoma 9.9
44 uremia 9.9
45 gastric adenocarcinoma 9.9
46 appendix adenocarcinoma 9.9
47 teratoma 9.9
48 astrocytoma 9.9
49 glioblastoma multiforme 9.9
50 mucinous adenocarcinoma 9.9

Graphical network of the top 20 diseases related to Gestational Choriocarcinoma:



Diseases related to Gestational Choriocarcinoma

Symptoms & Phenotypes for Gestational Choriocarcinoma

Human phenotypes related to Gestational Choriocarcinoma:

58 31 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 choriocarcinoma 58 31 obligate (100%) Obligate (100%) HP:0100768
2 metrorrhagia 58 31 hallmark (90%) Very frequent (99-80%) HP:0100608
3 spontaneous abortion 58 31 hallmark (90%) Very frequent (99-80%) HP:0005268
4 high maternal serum chorionic gonadotropin 58 31 hallmark (90%) Very frequent (99-80%) HP:0011433
5 neoplasm 58 Very frequent (99-80%)
6 trophoblastic tumor 58 Very frequent (99-80%)

Drugs & Therapeutics for Gestational Choriocarcinoma

Drugs for Gestational Choriocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved 1959-05-2, 59-05-2 126941
2
leucovorin Approved 58-05-9 6006 143
3
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
4 Immunologic Factors
5 Vitamin B Complex
6 Folic Acid Antagonists
7 Vitamin B9
8 Dermatologic Agents
9 Antirheumatic Agents
10 Folate
11 Immunosuppressive Agents
12 Antimetabolites

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prediction of Chemoresistance in Patients Treated for Gestational Trophoblastic Tumors Not yet recruiting NCT03488901

Search NIH Clinical Center for Gestational Choriocarcinoma

Genetic Tests for Gestational Choriocarcinoma

Anatomical Context for Gestational Choriocarcinoma

MalaCards organs/tissues related to Gestational Choriocarcinoma:

40
Ovary, Placenta, Brain, Lung, Uterus, Cervix, Liver

Publications for Gestational Choriocarcinoma

Articles related to Gestational Choriocarcinoma:

(show top 50) (show all 375)
# Title Authors PMID Year
1
Widespread choriocarcinoma metastases from de-differentiated gastro-esophageal junction primary adenocarcinoma: A case report with literature review. 61
31886402 2020
2
Fluorescence In Situ Hybridization for the X and Y Chromosome Centromeres Helps Differentiate Between Gestational and Nongestational Choriocarcinoma in Clinically Ambiguous Cases. 61
31846368 2019
3
[Endometrioid adenocarcinoma with a co-existing non-gestational choriocarcinoma in uterus]. 61
31791448 2019
4
A Case of Intraplacental Choriocarcinoma with Pulmonary Metastasis. 61
31762752 2019
5
Precision genotyping diagnosis of lung tumors with trophoblastic morphology in young women. 61
31028360 2019
6
Using short tandem repeat analysis for choriocarcinoma diagnosis: a case series. 61
31421690 2019
7
Short Tandem Repeats Define a Gestational Origin for Metastatic Choriocarcinoma. 61
30685255 2019
8
A case of intraplacental gestational choriocarcinoma; characterised by the methylation pattern of the early placenta and an absence of driver mutations. 61
31357948 2019
9
[A case of misdiagnose of non-gestational choriocarcinoma metastasis to left atrium]. 61
31366001 2019
10
An unusual cause of gynaecomastia in a male 61
31373476 2019
11
Male primary mediastinal choriocarcinoma with diffuse metastases: A case report. 61
31305456 2019
12
Oral etoposide for metastatic choriocarcinoma: a case report and review of guidelines. 61
30569343 2019
13
Clinical significance of circulating tumor cells in predicting disease progression and chemotherapy resistance in patients with gestational choriocarcinoma. 61
30070688 2019
14
Primary non-gestational uterine choriocarcinoma mimicking leiomyoma. 61
30775828 2019
15
The role of a semi-automated NanoVelcro system in capturing circulating tumor cells and evaluating their prognostic value for gestational choriocarcinoma. 61
30656300 2019
16
Stage IV Gestational Choriocarcinoma Diagnosed in the Third Trimester. 61
30531566 2019
17
A pilot study comparing the genetic molecular biology of gestational and non-gestational choriocarcinoma. 61
31814908 2019
18
Long noncoding RNA PCA3 contributes to the progression of choriocarcinoma by acting as a ceRNA against miR-106b. 61
31933978 2019
19
Pure nongestational uterine choriocarcinoma in postmenopausal women: a case report with literature review. 61
31132027 2019
20
Gestational Trophoblastic Tumors: A Timely Review of Diagnostic Pathology. 61
30407075 2019
21
High-risk gestational choriocarcinoma with an unusual presentation and the treatment course of refractory or quiescent/minimally invasive disease. 61
30302364 2018
22
Metastatic Nongestational Choriocarcinoma to the Brain: Case Report and Proposed Treatment Recommendations. 61
29678709 2018
23
Spontaneous renal hemorrhage secondary to choriocarcinoma in a man with congenital hypospadias and cryptorchidism: a case report and literature review. 61
29739453 2018
24
Transmission of a TP53 germline mutation from unaffected male carrier associated with pediatric glioblastoma in his child and gestational choriocarcinoma in his female partner. 61
29581140 2018
25
Daidzein induces choriocarcinoma cell apoptosis in a dose-dependent manner via the mitochondrial apoptotic pathway. 61
29436666 2018
26
A Rare Case of Gestational Choriocarcinoma Presenting as Cornual Ectopic Pregnancy. 61
29032067 2018
27
Metastatic gestational choriocarcinoma: a masquerader in obstetrics. 61
28550508 2018
28
Short tandem repeat analysis for confirmation of uterine non-gestational choriocarcinoma in a postmenopausal Taiwanese woman. 61
29465578 2018
29
Laparoscopic splenectomy for splenic rupture secondary to metastatic choriocarcinoma. 61
29536060 2018
30
Nonmetastatic Excised Gestational Choriocarcinoma: To Treat or Not to Treat. 61
29406249 2018
31
Relative Effects of Age, Race, and Stage on Mortality in Gestational Choriocarcinoma. 61
29232272 2018
32
Primary non-gestational choriocarcinoma of the uterine cervix with metaplastic transformation from adenocarcinoma: a case report. 61
28830246 2018
33
Is chemotherapy always necessary for patients with nonmetastatic gestational trophoblastic neoplasia with histopathological diagnosis of choriocarcinoma? 61
29248195 2018
34
A rare case of a giant arterio-venous fistula (AVF) following metastatic choriocarcinoma conditioning pulmonary embolism: multimodal transcatheter embolization using a simultaneous transarterial and transvenous approach. 61
30652161 2018
35
Gestational choriocarcinoma associated with a germline TP53 mutation. 61
28477316 2018
36
Gestational Tubal Choriocarcinoma Presenting as a Pregnancy of Unknown Location following Ovarian Induction. 61
29854512 2018
37
Debulking Surgery for Pelvic Recurrence After Surgically-treated Tubal Gestational Choriocarcinoma - A Case Report and Literature Review. 61
29277804 2018
38
Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature. 61
29681814 2018
39
Successful detection of SRY gene via fine needle biopsy: A case of extragenital gestational choriocarcinoma in the kidney. 61
29285373 2017
40
Choriocarcinoma in Women: Analysis of a Case Series With Genotyping. 61
28877059 2017
41
An extremely rare case of postpartum gestational choriocarcinoma with long-term survival. 61
28777426 2017
42
An unusual pulmonary metastatic manifestation of gestational choriocarcinoma: A diagnostic dilemma. 61
28869244 2017
43
A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature. 61
28728581 2017
44
Inhibitory Effects of Quercetin on Progression of Human Choriocarcinoma Cells Are Mediated Through PI3K/AKT and MAPK Signal Transduction Cascades. 61
27714811 2017
45
Gestational choriocarcinoma complicated by infective endocarditis during chemotherapy. 61
28217736 2017
46
Prognosis of gestational choriocarcinoma diagnosed incidentally during laparoscopy for a presumed cornual pregnancy: a report of five cases. 61
28607811 2017
47
Hemoptysis as primary manifestation in three women with choriocarcinoma with pulmonary metastasis: a case series. 61
28411623 2017
48
Biochemical analysis of intraplacental choriocarcinoma and fetomaternal transfusion. 61
28168818 2017
49
Primary Gastric Choriocarcinoma Presenting as a Pregnancy of Unknown Location. 61
28079767 2017
50
Gestational choriocarcinoma: Rare spinal metastasis during a viable pregnancy. 61
27987335 2017

Variations for Gestational Choriocarcinoma

Expression for Gestational Choriocarcinoma

Search GEO for disease gene expression data for Gestational Choriocarcinoma.

Pathways for Gestational Choriocarcinoma

Pathways related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 SLC6A6 SLC6A4 SLC5A6

GO Terms for Gestational Choriocarcinoma

Biological processes related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of JAK-STAT cascade GO:0046427 9.43 CSH2 CSH1
2 transmembrane transport GO:0055085 9.43 SLC6A6 SLC6A4 SLC5A6 SLC23A3 KCNH6 ABCG2
3 positive regulation of interleukin-12 production GO:0032735 9.4 IFNG HLA-G
4 animal organ development GO:0048513 9.37 CSH2 CSH1
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.33 IFNG CSH2 CSH1
6 growth hormone receptor signaling pathway GO:0060396 9.32 CSH2 CSH1
7 positive regulation of growth GO:0045927 9.26 CSH2 CSH1
8 biotin transport GO:0015878 8.62 SLC5A6 ABCG2

Molecular functions related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 symporter activity GO:0015293 9.33 SLC6A6 SLC6A4 SLC5A6
2 neurotransmitter:sodium symporter activity GO:0005328 8.96 SLC6A6 SLC6A4
3 growth hormone receptor binding GO:0005131 8.62 CSH2 CSH1

Sources for Gestational Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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