MCID: GST052
MIFTS: 45

Gestational Choriocarcinoma

Categories: Cancer diseases, Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Gestational Choriocarcinoma

MalaCards integrated aliases for Gestational Choriocarcinoma:

Name: Gestational Choriocarcinoma 12 59 15 73
Molar Pregnancy with Choriocarcinoma 12
Gestational Chorionepithelioma 12

Characteristics:

Orphanet epidemiological data:

59
gestational choriocarcinoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:2025
NCIt 50 C4646
SNOMED-CT 68 1884006
Orphanet 59 ORPHA99926
UMLS via Orphanet 74 C0349557
ICD10 via Orphanet 34 C58
UMLS 73 C0349557

Summaries for Gestational Choriocarcinoma

Disease Ontology : 12 A choriocarcicoma that develops in the presence of a preceding gestational event.

MalaCards based summary : Gestational Choriocarcinoma, also known as molar pregnancy with choriocarcinoma, is related to placental choriocarcinoma and choriocarcinoma. An important gene associated with Gestational Choriocarcinoma is H19 (H19, Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Cytokine Signaling in Immune system. The drugs leucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include ovary, placenta and cervix.

Related Diseases for Gestational Choriocarcinoma

Diseases related to Gestational Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 placental choriocarcinoma 31.6 ABCG2 SLC6A4
2 choriocarcinoma 31.5 ABCG2 CSH1 H19
3 gestational trophoblastic neoplasm 30.5 CSH1 H19
4 fallopian tube gestational choriocarcinoma 12.7
5 non-gestational choriocarcinoma 12.5
6 primary non-gestational choriocarcinoma of ovary 12.2
7 gestational trophoblastic tumor 11.4
8 gestational uterine corpus choriocarcinoma 11.2
9 ectopic pregnancy 10.4
10 hydatidiform mole, recurrent, 1 10.3
11 adenocarcinoma 10.2
12 invasive mole 10.2
13 trophoblastic neoplasm 10.1 CSH1 H19
14 central nervous system disease 10.0 H19 IFNG SLC6A4
15 persistent fetal circulation syndrome 9.9 ABCG2 CSH1
16 intussusception 9.9
17 pulmonary hypertension 9.9
18 infective endocarditis 9.9
19 endocarditis 9.9
20 respiratory failure 9.9
21 leiomyoma 9.9
22 pulmonary tuberculosis 9.9
23 teratoma 9.9
24 choriocarcinoma of ovary 9.9
25 malignant teratoma 9.9
26 glioblastoma 9.9
27 cerebral aneurysms 9.9
28 long qt syndrome 15 9.7 CALM3 CALM2 CALM1
29 long qt syndrome 1 9.7 CALM1 CALM2 CALM3
30 long qt syndrome 9.7 CALM1 CALM2 CALM3
31 external ear disease 9.7 CALM3 CALM2 CALM1
32 otomycosis 9.7 CALM3 CALM2 CALM1
33 otitis externa 9.7 CALM3 CALM2 CALM1
34 emery-dreifuss muscular dystrophy 5, autosomal dominant 9.7 CALM3 CALM2 CALM1
35 spontaneous ocular nystagmus 9.7 CALM3 CALM2 CALM1
36 deafness, autosomal recessive 44 9.7 CALM3 CALM2 CALM1
37 acute dacryocystitis 9.7 CALM3 CALM2 CALM1
38 dystonia 24 9.7 CALM3 CALM2 CALM1
39 triosephosphate isomerase deficiency 9.7 CALM3 CALM2 CALM1
40 tinea unguium 9.7 CALM3 CALM2 CALM1
41 leber congenital amaurosis 2 9.7 CALM3 CALM2 CALM1
42 clear cell acanthoma 9.7 CALM3 CALM2 CALM1
43 cardiomyopathy, dilated, 1a 9.7 CALM3 CALM2 CALM1
44 cardiomyopathy, dilated, 1p 9.7 CALM1 CALM2 CALM3
45 phaeohyphomycosis 9.7 CALM1 CALM2 CALM3
46 deafness, autosomal dominant 2a 9.7 CALM1 CALM2 CALM3
47 microcephaly 2, primary, autosomal recessive, with or without cortical malformations 9.6 CALM1 CALM2 CALM3
48 ceroid lipofuscinosis, neuronal, 11 9.6 CALM1 CALM2 CALM3
49 primary cutaneous amyloidosis 9.6 CALM1 CALM2 CALM3
50 catecholaminergic polymorphic ventricular tachycardia 9.6 CALM1 CALM2 CALM3

Graphical network of the top 20 diseases related to Gestational Choriocarcinoma:



Diseases related to Gestational Choriocarcinoma

Symptoms & Phenotypes for Gestational Choriocarcinoma

Drugs & Therapeutics for Gestational Choriocarcinoma

Drugs for Gestational Choriocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved 58-05-9 6006 143
2
Methotrexate Approved 59-05-2, 1959-05-2 126941
3
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
4 Dermatologic Agents
5 Immunologic Factors
6 Immunosuppressive Agents
7 Vitamin B9
8 Antimetabolites, Antineoplastic
9 Vitamin B Complex
10 Antimetabolites
11 Antirheumatic Agents
12 Nucleic Acid Synthesis Inhibitors
13 Folic Acid Antagonists
14 Folate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chemoresistance of Trophoblastic Tumors Not yet recruiting NCT03488901

Search NIH Clinical Center for Gestational Choriocarcinoma

Genetic Tests for Gestational Choriocarcinoma

Anatomical Context for Gestational Choriocarcinoma

MalaCards organs/tissues related to Gestational Choriocarcinoma:

41
Ovary, Placenta, Cervix, Liver, Lung, Brain, Uterus

Publications for Gestational Choriocarcinoma

Articles related to Gestational Choriocarcinoma:

(show top 50) (show all 175)
# Title Authors Year
1
Transmission of a <i>TP53</i> germline mutation from unaffected male carrier associated with pediatric glioblastoma in his child and gestational choriocarcinoma in his female partner. ( 29581140 )
2018
2
Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature. ( 29681814 )
2018
3
Debulking Surgery for Pelvic Recurrence After Surgically-treated Tubal Gestational Choriocarcinoma - A Case Report and Literature Review. ( 29277804 )
2018
4
Relative Effects of Age, Race, and Stage on Mortality in Gestational Choriocarcinoma. ( 29232272 )
2018
5
Short tandem repeat analysis for confirmation of uterine non-gestational choriocarcinoma in a postmenopausal Taiwanese woman. ( 29465578 )
2018
6
Nonmetastatic Excised Gestational Choriocarcinoma: To Treat or Not to Treat. ( 29406249 )
2018
7
Clinical significance of circulating tumor cells in predicting disease progression and chemotherapy resistance in patients with gestational choriocarcinoma. ( 30070688 )
2018
8
High-risk gestational choriocarcinoma with an unusual presentation and the treatment course of refractory or quiescent/minimally invasive disease. ( 30302364 )
2018
9
Stage IV Gestational Choriocarcinoma Diagnosed in the Third Trimester. ( 30531566 )
2018
10
Gestational choriocarcinoma associated with a germline TP53 mutation. ( 28477316 )
2017
11
Metastatic gestational choriocarcinoma: a masquerader in obstetrics. ( 28550508 )
2017
12
A Rare Case of Gestational Choriocarcinoma Presenting as Cornual Ectopic Pregnancy. ( 29032067 )
2017
13
Prognosis of gestational choriocarcinoma diagnosed incidentally during laparoscopy for a presumed cornual pregnancy: a report of five cases. ( 28607811 )
2017
14
A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature. ( 28728581 )
2017
15
An extremely rare case of postpartum gestational choriocarcinoma with long-term survival. ( 28777426 )
2017
16
Successful detection of SRY gene via fine needle biopsy: A case of extragenital gestational choriocarcinoma in the kidney. ( 29285373 )
2017
17
Primary non-gestational choriocarcinoma of the uterine cervix with metaplastic transformation from adenocarcinoma: a case report. ( 28830246 )
2017
18
Gestational choriocarcinoma complicated by infective endocarditis during chemotherapy. ( 28217736 )
2017
19
An unusual pulmonary metastatic manifestation of gestational choriocarcinoma: A diagnostic dilemma. ( 28869244 )
2017
20
Gestational choriocarcinoma: Rare spinal metastasis during a viable pregnancy. ( 27987335 )
2016
21
Gestational choriocarcinoma with renal and pulmonary metastases lacking a primary uterine origin. ( 28040140 )
2016
22
Disseminated gestational choriocarcinoma presenting with hepatic and uveal metastases, hook effect, and choriocarcinoma syndrome. ( 28104943 )
2016
23
Pure non-gestational choriocarcinoma arising in the ovary. ( 29894083 )
2016
24
Ectopic pregnancy with associated gestational choriocarcinoma in a California sea lion (Zalophus californianus). ( 27409239 )
2016
25
Solitary lung metastasis from gestational choriocarcinoma resected six years after hydatidiform mole: A case report. ( 27744215 )
2016
26
Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings. ( 27095467 )
2016
27
A retrospective study to evaluate single agent methotrexate treatment in low risk gestational choriocarcinoma in the United Kingdom. ( 25542400 )
2015
28
FIGO Stage III Metastatic Gestational Choriocarcinoma Developed From an Antecedent Partial Hydatidiform Molar Pregnancy Bearing a Numerical Chromosomal Aberration 68, XX: A Case Report and Literature Review. ( 26352546 )
2015
29
FIGO stage IV gestational choriocarcinoma misdiagnosed as pulmonary tuberculosis: A case report. ( 26622776 )
2015
30
Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case. ( 26075121 )
2015
31
Gestational choriocarcinoma after term pregnancy: a case report. ( 25826515 )
2015
32
Gestational choriocarcinoma with uterine serosal metastasis mimicking ruptured ectopic pregnancy: A case report. ( 26137037 )
2015
33
Intussusception in gestational choriocarcinoma (not histologically proven), resolving spontaneously with chemotherapy. ( 26420692 )
2015
34
Gestational choriocarcinoma of the cervix. ( 25365622 )
2014
35
Unusual gestational choriocarcinoma arising in an interstitial pregnancy. ( 25290382 )
2014
36
Gestational choriocarcinoma at Ibn Rochd Hospital, Casablanca, 2004-2010. ( 24995750 )
2014
37
Glycan profiling of gestational choriocarcinoma using a lectin microarray. ( 24424471 )
2014
38
An unusual cause of lower GI bleeding in a young woman: metastatic gestational choriocarcinoma. ( 22421497 )
2013
39
Primary intraplacental gestational choriocarcinoma: histologic and genetic analyses. ( 23202784 )
2013
40
Coexistent gestational choriocarcinoma and mixed adenocarcinoma of the uterus. ( 24020150 )
2013
41
Gestational choriocarcinoma in the fallopian tube. ( 24219747 )
2013
42
Treatment of gestational choriocarcinoma and massive ascites by hypothermic intraperitoneal perfusion chemotherapy guided by ultrasound followed by cytoreductive surgery. ( 24353600 )
2013
43
Clinical Outcome of a FIGO Stage IV Gestational Choriocarcinoma. ( 24163669 )
2013
44
Gestational Choriocarcinoma Metastasis to the Extraocular Muscle: A Case Report. ( 23924991 )
2013
45
Hypersensitivity to Etoposide in case of metastatic gestational choriocarcinoma. ( 24163666 )
2013
46
Gestational choriocarcinoma in liver mimicking ruptured ectopic pregnancy. ( 22663336 )
2012
47
Gestational choriocarcinoma arising in a tubal ectopic pregnancy: case report. ( 22053686 )
2011
48
Trophoblastic vasculogenic mimicry in gestational choriocarcinoma. ( 21217646 )
2011
49
Gestational choriocarcinoma of Fallopian tube diagnosed with a combination of p57KIP2 immunostaining and short tandem repeat analysis: case report. ( 21599798 )
2011
50
Subcutaneous mass as the primary manifestation of gestational choriocarcinoma: A case report. ( 24371601 )
2011

Variations for Gestational Choriocarcinoma

Expression for Gestational Choriocarcinoma

Search GEO for disease gene expression data for Gestational Choriocarcinoma.

Pathways for Gestational Choriocarcinoma

Pathways related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.27 ABCG2 CALM1 CALM2 CALM3 SLC7A5
2
Show member pathways
13.25 CALM1 CALM2 CALM3 CSH1 IFNG
3
Show member pathways
12.78 CALM1 CALM2 CALM3 IFNG
4 12.73 CALM1 CALM2 CALM3 IFNG
5
Show member pathways
12.54 CALM1 CALM2 CALM3 IFNG
6
Show member pathways
12.41 CALM1 CALM2 CALM3 IFNG
7
Show member pathways
12.34 CALM1 CALM2 IFNG
8
Show member pathways
12.34 CALM1 CALM2 CALM3
9
Show member pathways
12.33 CALM1 CALM2 CALM3
10
Show member pathways
12.33 CALM1 CALM2 CALM3
11
Show member pathways
12.31 CALM1 CALM2 CALM3
12
Show member pathways
12.3 CALM1 CALM2 CALM3
13
Show member pathways
12.29 CALM1 CALM2 CALM3
14 12.27 CALM1 CALM2 CALM3
15
Show member pathways
12.26 CALM1 CALM2 CALM3
16
Show member pathways
12.25 CALM1 CALM2 CALM3
17
Show member pathways
12.24 CALM1 CALM2 CALM3
18
Show member pathways
12.24 CALM1 CALM2 CALM3
19
Show member pathways
12.23 CALM1 CALM2 CALM3
20
Show member pathways
12.21 CALM1 CALM2 CALM3
21
Show member pathways
12.19 CALM1 CALM2 CALM3 IFNG
22
Show member pathways
12.17 CALM1 CALM2 CALM3
23
Show member pathways
12.17 CALM1 CALM2 CALM3
24
Show member pathways
12.15 CALM1 CALM2 CALM3
25
Show member pathways
12.12 CALM1 CALM2 CALM3
26
Show member pathways
12.12 CALM1 CALM2 CALM3
27 12.11 CALM1 CALM2 CALM3 IFNG
28
Show member pathways
12.1 CALM1 CALM2 CALM3
29
Show member pathways
12.09 CALM1 CALM2 CALM3
30
Show member pathways
12.08 CALM1 CALM2 CALM3
31 12.08 CALM1 CALM2 CALM3
32
Show member pathways
12.06 CALM1 CALM2 CALM3
33
Show member pathways
12.04 CALM1 CALM2 CALM3
34 12 CALM1 CALM2 CALM3
35
Show member pathways
11.98 CALM1 CALM2 CALM3 IFNG
36
Show member pathways
11.94 CALM1 CALM2 CALM3
37
Show member pathways
11.92 CALM1 CALM2 CALM3
38 11.92 CALM1 CALM2 CALM3 IFNG
39
Show member pathways
11.89 CALM1 CALM2 CALM3
40
Show member pathways
11.86 CALM1 CALM2 CALM3
41 11.84 CALM1 CALM2 CALM3
42 11.84 CALM1 CALM2 CALM3
43 11.82 CALM1 CALM2 CALM3
44
Show member pathways
11.81 CALM1 CALM2 CALM3
45
Show member pathways
11.78 CALM1 CALM2 CALM3
46
Show member pathways
11.77 CALM1 CALM2 CALM3
47
Show member pathways
11.7 CALM1 CALM2 CALM3
48
Show member pathways
11.69 CALM1 CALM2 CALM3
49 11.67 CALM1 CALM2 CALM3
50
Show member pathways
11.66 CALM1 CALM2 CALM3

GO Terms for Gestational Choriocarcinoma

Cellular components related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.63 CALM1 CALM2 CALM3
2 mitochondrial membrane GO:0031966 9.61 ABCG2 CALM1 CALM3
3 myelin sheath GO:0043209 9.58 CALM1 CALM2 CALM3
4 vesicle GO:0031982 9.56 CALM1 CALM2 CALM3 CSH1
5 spindle pole GO:0000922 9.54 CALM1 CALM2 CALM3
6 sarcomere GO:0030017 9.5 CALM1 CALM2 CALM3
7 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
8 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
9 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 calcium-mediated signaling GO:0019722 9.78 CALM1 CALM2 CALM3
2 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
3 substantia nigra development GO:0021762 9.76 CALM1 CALM2 CALM3
4 regulation of cytokinesis GO:0032465 9.75 CALM1 CALM2 CALM3
5 regulation of heart rate GO:0002027 9.74 CALM1 CALM2 CALM3
6 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.72 CALM1 CALM2 CALM3
7 positive regulation of protein dephosphorylation GO:0035307 9.71 CALM1 CALM2 CALM3
8 positive regulation of protein autophosphorylation GO:0031954 9.7 CALM1 CALM2 CALM3
9 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.69 CALM1 CALM2 CALM3
10 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.67 CALM1 CALM2 CALM3
11 response to amphetamine GO:0001975 9.65 CALM1 CALM3
12 regulation of cardiac muscle contraction GO:0055117 9.65 CALM1 CALM2 CALM3
13 activation of adenylate cyclase activity GO:0007190 9.64 CALM1 CALM3
14 positive regulation of DNA binding GO:0043388 9.64 CALM2 CALM3
15 positive regulation of nitric-oxide synthase activity GO:0051000 9.63 CALM1 CALM3
16 response to corticosterone GO:0051412 9.63 CALM1 CALM3
17 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.63 CALM1 CALM2 CALM3
18 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.62 CALM1 CALM3
19 regulation of synaptic vesicle endocytosis GO:1900242 9.62 CALM1 CALM3
20 establishment of protein localization to membrane GO:0090150 9.61 CALM1 CALM3
21 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.61 CALM1 CALM2 CALM3
22 regulation of high voltage-gated calcium channel activity GO:1901841 9.6 CALM1 CALM3
23 detection of calcium ion GO:0005513 9.58 CALM1 CALM2 CALM3
24 establishment of protein localization to mitochondrial membrane GO:0090151 9.56 CALM1 CALM3
25 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.54 CALM1 CALM2 CALM3
26 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.5 CALM1 CALM2 CALM3
27 positive regulation of protein serine/threonine kinase activity GO:0071902 9.46 CALM1 CALM2 CALM3 IFNG
28 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.43 CALM1 CALM2 CALM3
29 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
30 positive regulation by host of symbiont cAMP-mediated signal transduction GO:0075206 8.8 CALM1 CALM2 CALM3

Molecular functions related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 ion channel binding GO:0044325 9.69 CALM1 CALM2 CALM3
2 disordered domain specific binding GO:0097718 9.63 CALM1 CALM2 CALM3
3 protein serine/threonine kinase activator activity GO:0043539 9.58 CALM1 CALM2 CALM3
4 enzyme regulator activity GO:0030234 9.54 CALM1 CALM3
5 nitric-oxide synthase binding GO:0050998 9.54 CALM1 CALM3 SLC6A4
6 phosphatidylinositol 3-kinase binding GO:0043548 9.52 CALM1 CALM3
7 titin binding GO:0031432 9.5 CALM1 CALM2 CALM3
8 calcium channel inhibitor activity GO:0019855 9.49 CALM1 CALM2
9 nitric-oxide synthase regulator activity GO:0030235 9.48 CALM1 CALM3
10 type 3 metabotropic glutamate receptor binding GO:0031800 9.43 CALM1 CALM3
11 adenylate cyclase binding GO:0008179 9.43 CALM1 CALM2 CALM3
12 protein phosphatase activator activity GO:0072542 9.33 CALM1 CALM2 CALM3
13 adenylate cyclase activator activity GO:0010856 9.13 CALM1 CALM2 CALM3
14 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Gestational Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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