MCID: GST052
MIFTS: 37

Gestational Choriocarcinoma

Categories: Cancer diseases, Fetal diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Gestational Choriocarcinoma

MalaCards integrated aliases for Gestational Choriocarcinoma:

Name: Gestational Choriocarcinoma 12 60 15 74
Molar Pregnancy with Choriocarcinoma 12
Gestational Chorionepithelioma 12

Characteristics:

Orphanet epidemiological data:

60
gestational choriocarcinoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:2025
NCIt 51 C4646
SNOMED-CT 69 1884006
ICD10 via Orphanet 35 C58
UMLS via Orphanet 75 C0349557
Orphanet 60 ORPHA99926
UMLS 74 C0349557

Summaries for Gestational Choriocarcinoma

Disease Ontology : 12 A choriocarcicoma that develops in the presence of a preceding gestational event.

MalaCards based summary : Gestational Choriocarcinoma, also known as molar pregnancy with choriocarcinoma, is related to placental choriocarcinoma and choriocarcinoma. An important gene associated with Gestational Choriocarcinoma is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Aryl Hydrocarbon Receptor Pathway and Amino acid transport across the plasma membrane. The drugs leucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include ovary, placenta and cervix.

Related Diseases for Gestational Choriocarcinoma

Diseases related to Gestational Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 placental choriocarcinoma 31.7 ABCG2 SLC6A4
2 choriocarcinoma 31.1 ABCG2 CSH1 ENPEP H19
3 gestational trophoblastic neoplasm 30.6 CSH1 H19
4 fallopian tube gestational choriocarcinoma 12.7
5 non-gestational choriocarcinoma 12.6
6 primary non-gestational choriocarcinoma of ovary 12.3
7 gestational trophoblastic tumor 11.4
8 gestational uterine corpus choriocarcinoma 11.2
9 ectopic pregnancy 10.4
10 hydatidiform mole, recurrent, 1 10.3
11 adenocarcinoma 10.2
12 invasive mole 10.2
13 microscopic colitis 10.2 IFNG SLC6A4
14 trophoblastic neoplasm 10.1 CSH1 H19
15 sclerosing cholangitis, neonatal 10.1
16 central nervous system disease 10.0 H19 IFNG SLC6A4
17 human immunodeficiency virus infectious disease 10.0 ENPEP IFNG
18 persistent fetal circulation syndrome 9.9 ABCG2 CSH1
19 intussusception 9.9
20 graves disease 1 9.9
21 endometrial cancer 9.9
22 hemorrhage, intracerebral 9.9
23 pulmonary hypertension 9.9
24 infective endocarditis 9.9
25 thrombosis 9.9
26 endocarditis 9.9
27 respiratory failure 9.9
28 allergic hypersensitivity disease 9.9
29 leiomyoma 9.9
30 pulmonary tuberculosis 9.9
31 glioblastoma multiforme 9.9
32 teratoma 9.9
33 choriocarcinoma of ovary 9.9
34 malignant teratoma 9.9
35 active peptic ulcer disease 9.9
36 glioblastoma 9.9
37 cerebral aneurysms 9.9
38 renal cell carcinoma, nonpapillary 9.7 ABCG2 H19 IFNG

Graphical network of the top 20 diseases related to Gestational Choriocarcinoma:



Diseases related to Gestational Choriocarcinoma

Symptoms & Phenotypes for Gestational Choriocarcinoma

Drugs & Therapeutics for Gestational Choriocarcinoma

Drugs for Gestational Choriocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved 58-05-9 143 6006
2
Methotrexate Approved 1959-05-2, 59-05-2 126941
3
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
4 Immunosuppressive Agents
5 Folic Acid Antagonists
6 Immunologic Factors
7 Vitamin B9
8 Vitamin B Complex
9 Antirheumatic Agents
10 Folate
11 Antimetabolites
12 Nucleic Acid Synthesis Inhibitors
13 Antimetabolites, Antineoplastic
14 Dermatologic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chemoresistance of Trophoblastic Tumors Not yet recruiting NCT03488901

Search NIH Clinical Center for Gestational Choriocarcinoma

Genetic Tests for Gestational Choriocarcinoma

Anatomical Context for Gestational Choriocarcinoma

MalaCards organs/tissues related to Gestational Choriocarcinoma:

42
Ovary, Placenta, Cervix, Liver, Lung, Brain, Uterus

Publications for Gestational Choriocarcinoma

Articles related to Gestational Choriocarcinoma:

(show top 50) (show all 176)
# Title Authors Year
1
Clinical significance of circulating tumor cells in predicting disease progression and chemotherapy resistance in patients with gestational choriocarcinoma. ( 30070688 )
2019
2
Stage IV Gestational Choriocarcinoma Diagnosed in the Third Trimester. ( 30531566 )
2019
3
The role of a semi-automated NanoVelcro system in capturing circulating tumor cells and evaluating their prognostic value for gestational choriocarcinoma. ( 30656300 )
2019
4
Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature. ( 29681814 )
2018
5
High-risk gestational choriocarcinoma with an unusual presentation and the treatment course of refractory or quiescent/minimally invasive disease. ( 30302364 )
2018
6
Gestational choriocarcinoma associated with a germline TP53 mutation. ( 28477316 )
2018
7
Metastatic gestational choriocarcinoma: a masquerader in obstetrics. ( 28550508 )
2018
8
Primary non-gestational choriocarcinoma of the uterine cervix with metaplastic transformation from adenocarcinoma: a case report. ( 28830246 )
2018
9
A Rare Case of Gestational Choriocarcinoma Presenting as Cornual Ectopic Pregnancy. ( 29032067 )
2018
10
Relative Effects of Age, Race, and Stage on Mortality in Gestational Choriocarcinoma. ( 29232272 )
2018
11
Debulking Surgery for Pelvic Recurrence After Surgically-treated Tubal Gestational Choriocarcinoma - A Case Report and Literature Review. ( 29277804 )
2018
12
Nonmetastatic Excised Gestational Choriocarcinoma: To Treat or Not to Treat. ( 29406249 )
2018
13
Short tandem repeat analysis for confirmation of uterine non-gestational choriocarcinoma in a postmenopausal Taiwanese woman. ( 29465578 )
2018
14
Transmission of a TP53 germline mutation from unaffected male carrier associated with pediatric glioblastoma in his child and gestational choriocarcinoma in his female partner. ( 29581140 )
2018
15
Gestational choriocarcinoma: Rare spinal metastasis during a viable pregnancy. ( 27987335 )
2017
16
Gestational choriocarcinoma complicated by infective endocarditis during chemotherapy. ( 28217736 )
2017
17
Prognosis of gestational choriocarcinoma diagnosed incidentally during laparoscopy for a presumed cornual pregnancy: a report of five cases. ( 28607811 )
2017
18
A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature. ( 28728581 )
2017
19
An extremely rare case of postpartum gestational choriocarcinoma with long-term survival. ( 28777426 )
2017
20
An unusual pulmonary metastatic manifestation of gestational choriocarcinoma: A diagnostic dilemma. ( 28869244 )
2017
21
Successful detection of SRY gene via fine needle biopsy: A case of extragenital gestational choriocarcinoma in the kidney. ( 29285373 )
2017
22
Gestational choriocarcinoma with renal and pulmonary metastases lacking a primary uterine origin. ( 28040140 )
2016
23
Disseminated gestational choriocarcinoma presenting with hepatic and uveal metastases, hook effect, and choriocarcinoma syndrome. ( 28104943 )
2016
24
FIGO Stage III Metastatic Gestational Choriocarcinoma Developed From an Antecedent Partial Hydatidiform Molar Pregnancy Bearing a Numerical Chromosomal Aberration 68, XX: A Case Report and Literature Review. ( 26352546 )
2016
25
Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings. ( 27095467 )
2016
26
Ectopic pregnancy with associated gestational choriocarcinoma in a California sea lion (Zalophus californianus). ( 27409239 )
2016
27
Solitary lung metastasis from gestational choriocarcinoma resected six years after hydatidiform mole: A case report. ( 27744215 )
2016
28
Pure non-gestational choriocarcinoma arising in the ovary. ( 29894083 )
2016
29
Gestational choriocarcinoma after term pregnancy: a case report. ( 25826515 )
2015
30
Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case. ( 26075121 )
2015
31
Gestational choriocarcinoma with uterine serosal metastasis mimicking ruptured ectopic pregnancy: A case report. ( 26137037 )
2015
32
Intussusception in gestational choriocarcinoma (not histologically proven), resolving spontaneously with chemotherapy. ( 26420692 )
2015
33
FIGO stage IV gestational choriocarcinoma misdiagnosed as pulmonary tuberculosis: A case report. ( 26622776 )
2015
34
A retrospective study to evaluate single agent methotrexate treatment in low risk gestational choriocarcinoma in the United Kingdom. ( 25542400 )
2015
35
Gestational choriocarcinoma metastasis to the extraocular muscle: a case report. ( 23924991 )
2014
36
Glycan profiling of gestational choriocarcinoma using a lectin microarray. ( 24424471 )
2014
37
Gestational choriocarcinoma at Ibn Rochd Hospital, Casablanca, 2004-2010. ( 24995750 )
2014
38
Unusual gestational choriocarcinoma arising in an interstitial pregnancy. ( 25290382 )
2014
39
Gestational choriocarcinoma of the cervix. ( 25365622 )
2014
40
Coexistent gestational choriocarcinoma and mixed adenocarcinoma of the uterus. ( 24020150 )
2013
41
Hypersensitivity to Etoposide in case of metastatic gestational choriocarcinoma. ( 24163666 )
2013
42
Clinical Outcome of a FIGO Stage IV Gestational Choriocarcinoma. ( 24163669 )
2013
43
Gestational choriocarcinoma in the fallopian tube. ( 24219747 )
2013
44
Treatment of gestational choriocarcinoma and massive ascites by hypothermic intraperitoneal perfusion chemotherapy guided by ultrasound followed by cytoreductive surgery. ( 24353600 )
2013
45
An unusual cause of lower GI bleeding in a young woman: metastatic gestational choriocarcinoma. ( 22421497 )
2013
46
Primary intraplacental gestational choriocarcinoma: histologic and genetic analyses. ( 23202784 )
2013
47
Gestational choriocarcinoma in liver mimicking ruptured ectopic pregnancy. ( 22663336 )
2012
48
Gestational choriocarcinoma arising in a tubal ectopic pregnancy: case report. ( 22053686 )
2011
49
Trophoblastic vasculogenic mimicry in gestational choriocarcinoma. ( 21217646 )
2011
50
Gestational choriocarcinoma of Fallopian tube diagnosed with a combination of p57KIP2 immunostaining and short tandem repeat analysis: case report. ( 21599798 )
2011

Variations for Gestational Choriocarcinoma

Expression for Gestational Choriocarcinoma

Search GEO for disease gene expression data for Gestational Choriocarcinoma.

Pathways for Gestational Choriocarcinoma

Pathways related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.64 IFNG SLC7A5
2
Show member pathways
10.14 SLC6A6 SLC7A5

GO Terms for Gestational Choriocarcinoma

Cellular components related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 8.62 ENPEP SLC7A5

Biological processes related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.37 CSH1 IFNG
2 amino acid transport GO:0006865 9.32 SLC6A6 SLC7A5
3 cellular amino acid metabolic process GO:0006520 9.26 SLC6A6 SLC7A5
4 neurotransmitter transport GO:0006836 9.16 SLC6A4 SLC6A6
5 amino acid transmembrane transport GO:0003333 8.96 SLC6A6 SLC7A5
6 transmembrane transport GO:0055085 8.92 ABCG2 SLC6A4 SLC6A6 SLC7A5

Molecular functions related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid transmembrane transporter activity GO:0015171 8.96 SLC6A6 SLC7A5
2 neurotransmitter:sodium symporter activity GO:0005328 8.62 SLC6A4 SLC6A6

Sources for Gestational Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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