MCID: GST052
MIFTS: 39

Gestational Choriocarcinoma

Categories: Reproductive diseases, Rare diseases, Cancer diseases, Fetal diseases

Aliases & Classifications for Gestational Choriocarcinoma

MalaCards integrated aliases for Gestational Choriocarcinoma:

Name: Gestational Choriocarcinoma 12 59 15 73
Molar Pregnancy with Choriocarcinoma 12
Gestational Chorionepithelioma 12

Characteristics:

Orphanet epidemiological data:

59
gestational choriocarcinoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:2025
NCIt 50 C4646
Orphanet 59 ORPHA99926
UMLS via Orphanet 74 C0349557
ICD10 via Orphanet 34 C58
UMLS 73 C0349557

Summaries for Gestational Choriocarcinoma

MalaCards based summary : Gestational Choriocarcinoma, also known as molar pregnancy with choriocarcinoma, is related to choriocarcinoma and gestational trophoblastic neoplasm. An important gene associated with Gestational Choriocarcinoma is H19 (H19, Imprinted Maternally Expressed Transcript
Prominent expression of H19 was found in placental site trophoblastic tumor and gestational choriocarcinoma.
Dysfunction Pattern: Regulation [up-regulated]), and among its related pathways/superpathways are Toll Comparative Pathway and Tuberculosis. Affiliated tissues include ovary, placenta and cervix.

Wikipedia : 76 Gestational choriocarcinoma is a malignant trophoblastic tumour arising from any gestational event... more...

Related Diseases for Gestational Choriocarcinoma

Diseases related to Gestational Choriocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 choriocarcinoma 31.1 ABCG2 CSH1 H19
2 gestational trophoblastic neoplasm 30.8 CSH1 H19
3 fallopian tube gestational choriocarcinoma 12.3
4 non-gestational choriocarcinoma 12.3
5 primary non-gestational choriocarcinoma of ovary 12.1
6 gestational trophoblastic tumor 11.3
7 microscopic colitis 10.4 IFNG SLC6A4
8 trophoblastic neoplasm 10.3 CSH1 H19
9 ectopic pregnancy 10.2
10 hydatidiform mole, recurrent, 1 10.1
11 adenocarcinoma 10.1
12 invasive mole 10.1
13 choroiditis 9.9
14 intussusception 9.8
15 aging 9.8
16 pulmonary hypertension 9.8
17 hepatitis 9.8
18 infective endocarditis 9.8
19 endocarditis 9.8
20 respiratory failure 9.8
21 leiomyoma 9.8
22 pulmonary tuberculosis 9.8
23 cerebritis 9.8
24 choriocarcinoma of ovary 9.8
25 germ cells tumors 9.8
26 glioblastoma 9.8
27 malignant germ cell tumor 9.8
28 aneurysm 9.8
29 cerebral aneurysms 9.8
30 acute dacryocystitis 9.8 CALM1 CALM3
31 external ear disease 9.7 CALM1 CALM3
32 long qt syndrome 15 9.7 CALM1 CALM3
33 otitis externa 9.7 CALM1 CALM3
34 otomycosis 9.7 CALM1 CALM3
35 spontaneous ocular nystagmus 9.7 CALM1 CALM3
36 deafness, autosomal recessive 44 9.7 CALM1 CALM3
37 dystonia 24 9.7 CALM1 CALM3
38 persistent fetal circulation syndrome 9.7 ABCG2 CSH1
39 triosephosphate isomerase deficiency 9.7 CALM1 CALM3
40 leber congenital amaurosis 2 9.6 CALM1 CALM3
41 clear cell acanthoma 9.6 CALM1 CALM3
42 cardiomyopathy, dilated, 1a 9.5 CALM1 CALM3
43 cardiomyopathy, dilated, 1p 9.5 CALM1 CALM3
44 sporotrichosis 9.5 CALM1 CALM3 IFNG
45 primary systemic mycosis 9.4 CALM1 CALM3 IFNG
46 deafness, autosomal dominant 2a 9.3 CALM1 CALM3
47 placental choriocarcinoma 9.3 ABCG2 SLC6A4
48 long qt syndrome 9.2 CALM1 CALM3 ENPEP

Graphical network of the top 20 diseases related to Gestational Choriocarcinoma:



Diseases related to Gestational Choriocarcinoma

Symptoms & Phenotypes for Gestational Choriocarcinoma

Drugs & Therapeutics for Gestational Choriocarcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chemoresistance of Trophoblastic Tumors Not yet recruiting NCT03488901

Search NIH Clinical Center for Gestational Choriocarcinoma

Genetic Tests for Gestational Choriocarcinoma

Anatomical Context for Gestational Choriocarcinoma

MalaCards organs/tissues related to Gestational Choriocarcinoma:

41
Ovary, Placenta, Cervix, Liver, Uterus, Lung, Brain

Publications for Gestational Choriocarcinoma

Articles related to Gestational Choriocarcinoma:

(show top 50) (show all 171)
# Title Authors Year
1
Transmission of a <i>TP53</i> germline mutation from unaffected male carrier associated with pediatric glioblastoma in his child and gestational choriocarcinoma in his female partner. ( 29581140 )
2018
2
Non-Gestational Choriocarcinoma with Widespread Metastases Presenting with Type 1 Respiratory Failure in a 39-Year-Old Female: Case Report and Review of the Literature. ( 29681814 )
2018
3
Debulking Surgery for Pelvic Recurrence After Surgically-treated Tubal Gestational Choriocarcinoma - A Case Report and Literature Review. ( 29277804 )
2018
4
Relative Effects of Age, Race, and Stage on Mortality in Gestational Choriocarcinoma. ( 29232272 )
2018
5
Short tandem repeat analysis for confirmation of uterine non-gestational choriocarcinoma in a postmenopausal Taiwanese woman. ( 29465578 )
2018
6
Nonmetastatic Excised Gestational Choriocarcinoma: To Treat or Not to Treat. ( 29406249 )
2018
7
Gestational choriocarcinoma associated with a germline TP53 mutation. ( 28477316 )
2017
8
Metastatic gestational choriocarcinoma: a masquerader in obstetrics. ( 28550508 )
2017
9
A Rare Case of Gestational Choriocarcinoma Presenting as Cornual Ectopic Pregnancy. ( 29032067 )
2017
10
Prognosis of gestational choriocarcinoma diagnosed incidentally during laparoscopy for a presumed cornual pregnancy: a report of five cases. ( 28607811 )
2017
11
A gestational choriocarcinoma of the ovary diagnosed by DNA polymorphic analysis: a case report and systematic review of the literature. ( 28728581 )
2017
12
An extremely rare case of postpartum gestational choriocarcinoma with long-term survival. ( 28777426 )
2017
13
Successful detection of SRY gene via fine needle biopsy: A case of extragenital gestational choriocarcinoma in the kidney. ( 29285373 )
2017
14
Primary non-gestational choriocarcinoma of the uterine cervix with metaplastic transformation from adenocarcinoma: a case report. ( 28830246 )
2017
15
Gestational choriocarcinoma complicated by infective endocarditis during chemotherapy. ( 28217736 )
2017
16
An unusual pulmonary metastatic manifestation of gestational choriocarcinoma: A diagnostic dilemma. ( 28869244 )
2017
17
Gestational choriocarcinoma: Rare spinal metastasis during a viable pregnancy. ( 27987335 )
2016
18
Gestational choriocarcinoma with renal and pulmonary metastases lacking a primary uterine origin. ( 28040140 )
2016
19
Disseminated gestational choriocarcinoma presenting with hepatic and uveal metastases, hook effect, and choriocarcinoma syndrome. ( 28104943 )
2016
20
Pure non-gestational choriocarcinoma arising in the ovary. ( 29894083 )
2016
21
Ectopic pregnancy with associated gestational choriocarcinoma in a California sea lion (Zalophus californianus). ( 27409239 )
2016
22
Solitary lung metastasis from gestational choriocarcinoma resected six years after hydatidiform mole: A case report. ( 27744215 )
2016
23
Primary gestational choriocarcinoma of the vagina: magnetic resonance imaging findings. ( 27095467 )
2016
24
A retrospective study to evaluate single agent methotrexate treatment in low risk gestational choriocarcinoma in the United Kingdom. ( 25542400 )
2015
25
FIGO Stage III Metastatic Gestational Choriocarcinoma Developed From an Antecedent Partial Hydatidiform Molar Pregnancy Bearing a Numerical Chromosomal Aberration 68, XX: A Case Report and Literature Review. ( 26352546 )
2015
26
FIGO stage IV gestational choriocarcinoma misdiagnosed as pulmonary tuberculosis: A case report. ( 26622776 )
2015
27
Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case. ( 26075121 )
2015
28
Gestational choriocarcinoma after term pregnancy: a case report. ( 25826515 )
2015
29
Gestational choriocarcinoma with uterine serosal metastasis mimicking ruptured ectopic pregnancy: A case report. ( 26137037 )
2015
30
Intussusception in gestational choriocarcinoma (not histologically proven), resolving spontaneously with chemotherapy. ( 26420692 )
2015
31
Gestational choriocarcinoma of the cervix. ( 25365622 )
2014
32
Unusual gestational choriocarcinoma arising in an interstitial pregnancy. ( 25290382 )
2014
33
Gestational choriocarcinoma at Ibn Rochd Hospital, Casablanca, 2004-2010. ( 24995750 )
2014
34
Glycan profiling of gestational choriocarcinoma using a lectin microarray. ( 24424471 )
2014
35
An unusual cause of lower GI bleeding in a young woman: metastatic gestational choriocarcinoma. ( 22421497 )
2013
36
Primary intraplacental gestational choriocarcinoma: histologic and genetic analyses. ( 23202784 )
2013
37
Coexistent gestational choriocarcinoma and mixed adenocarcinoma of the uterus. ( 24020150 )
2013
38
Gestational choriocarcinoma in the fallopian tube. ( 24219747 )
2013
39
Treatment of gestational choriocarcinoma and massive ascites by hypothermic intraperitoneal perfusion chemotherapy guided by ultrasound followed by cytoreductive surgery. ( 24353600 )
2013
40
Clinical Outcome of a FIGO Stage IV Gestational Choriocarcinoma. ( 24163669 )
2013
41
Gestational Choriocarcinoma Metastasis to the Extraocular Muscle: A Case Report. ( 23924991 )
2013
42
Hypersensitivity to Etoposide in case of metastatic gestational choriocarcinoma. ( 24163666 )
2013
43
Gestational choriocarcinoma in liver mimicking ruptured ectopic pregnancy. ( 22663336 )
2012
44
Gestational choriocarcinoma arising in a tubal ectopic pregnancy: case report. ( 22053686 )
2011
45
Trophoblastic vasculogenic mimicry in gestational choriocarcinoma. ( 21217646 )
2011
46
Gestational choriocarcinoma of Fallopian tube diagnosed with a combination of p57KIP2 immunostaining and short tandem repeat analysis: case report. ( 21599798 )
2011
47
Subcutaneous mass as the primary manifestation of gestational choriocarcinoma: A case report. ( 24371601 )
2011
48
A case of primary tubal gestational choriocarcinoma. ( 20522081 )
2010
49
Gestational choriocarcinoma presenting as hemothorax. ( 22842324 )
2010
50
Gestational choriocarcinoma analyzed by polymerase chain reaction amplification of polymorphic VNTR and human leukocyte antigen regions. ( 20435306 )
2010

Variations for Gestational Choriocarcinoma

Expression for Gestational Choriocarcinoma

Search GEO for disease gene expression data for Gestational Choriocarcinoma.

Pathways for Gestational Choriocarcinoma

GO Terms for Gestational Choriocarcinoma

Cellular components related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle GO:0031982 9.33 CALM1 CALM3 CSH1
2 spindle microtubule GO:0005876 9.26 CALM1 CALM3
3 calcium channel complex GO:0034704 8.96 CALM1 CALM3
4 catalytic complex GO:1902494 8.62 CALM1 CALM3

Biological processes related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 regulation of cytokinesis GO:0032465 9.58 CALM1 CALM3
2 regulation of heart rate GO:0002027 9.57 CALM1 CALM3
3 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.56 CALM1 CALM3
4 positive regulation of protein autophosphorylation GO:0031954 9.55 CALM1 CALM3
5 positive regulation of protein dephosphorylation GO:0035307 9.54 CALM1 CALM3
6 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.52 CALM1 CALM3
7 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.51 CALM1 CALM3
8 regulation of cardiac muscle contraction GO:0055117 9.49 CALM1 CALM3
9 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.48 CALM1 CALM3
10 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.46 CALM1 CALM3
11 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.43 CALM1 CALM3
12 detection of calcium ion GO:0005513 9.4 CALM1 CALM3
13 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.37 CALM1 CALM3
14 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.32 CALM1 CALM3
15 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.26 CALM1 CALM3
16 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.16 CALM1 CALM3
17 positive regulation of protein serine/threonine kinase activity GO:0071902 9.13 CALM1 CALM3 IFNG
18 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.62 CALM1 CALM3

Molecular functions related to Gestational Choriocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 9.37 CALM1 CALM3
2 protein serine/threonine kinase activator activity GO:0043539 9.32 CALM1 CALM3
3 titin binding GO:0031432 9.26 CALM1 CALM3
4 adenylate cyclase binding GO:0008179 9.16 CALM1 CALM3
5 protein phosphatase activator activity GO:0072542 8.96 CALM1 CALM3
6 N-terminal myristoylation domain binding GO:0031997 8.62 CALM1 CALM3

Sources for Gestational Choriocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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