GDM
MCID: GST033
MIFTS: 62

Gestational Diabetes (GDM)

Categories: Blood diseases, Metabolic diseases

Aliases & Classifications for Gestational Diabetes

MalaCards integrated aliases for Gestational Diabetes:

Name: Gestational Diabetes 12 25 15 63 73
Gestational Diabetes Mellitus 12 76 25 15
Gdm 12 25 48
Diabetes Mellitus, Gestational 25 13
Maternal Gestational Diabetes Mellitus 12
Diabetes Mellitus Arising in Pregnancy 25
Diabetes Mellitus, Pregnancy Related 25
Diabetes, Pregnancy-Induced 25
Diabetes, Gestational 44
Diabetes Gestational 55

Classifications:



External Ids:

Disease Ontology 12 DOID:11714
ICD10 33 O24.4
MeSH 44 D016640
NCIt 50 C34942
SNOMED-CT 68 11687002
UMLS 73 C0085207

Summaries for Gestational Diabetes

PubMed Health : 63 About gestational diabetes: Most women's blood sugar levels remain normal during pregnancy. But if blood sugar levels go above a certain value, they are considered to have gestational diabetes. This is the case in about 4 out of 100 women.It is not always clear whether a woman just has slightly higher blood sugar levels or whether she has gestational diabetes. Women’s metabolism changes over the course of pregnancy anyway: It takes longer for the cells in their body to absorb the sugar in their blood after meals. This means that elevated blood sugar levels are often a normal part of pregnancy – and they usually return to normal afterwards. Having gestational diabetes doesn’t mean that you have developed chronic diabetes.The raised blood sugar levels in gestational diabetes slightly increase the risk of certain rare birth complications. This risk can usually be lowered by changing your diet, though.The vast majority of women who develop gestational diabetes experience an otherwise normal pregnancy and go on to give birth to a healthy baby.

MalaCards based summary : Gestational Diabetes, also known as gestational diabetes mellitus, is related to maturity-onset diabetes of the young, type 2 and fetal macrosomia, and has symptoms including hyperemesis gravidarum, pelvic pain and morning sickness. An important gene associated with Gestational Diabetes is INS (Insulin), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Metformin and Resveratrol have been mentioned in the context of this disorder. Affiliated tissues include testes, placenta and ovary, and related phenotypes are Decreased viability and Decreased viability

Genetics Home Reference : 25 Gestational diabetes is a disorder characterized by abnormally high blood sugar levels during pregnancy. Affected women do not have diabetes before they are pregnant, and most of these women go back to being nondiabetic soon after the baby is born. The disease has a 30 to 70 percent chance of recurring in subsequent pregnancies. Additionally, about half of women with gestational diabetes develop another form of diabetes, known as type 2 diabetes, within a few years after their pregnancy.

Wikipedia : 76 Gestational diabetes is a condition in which a woman without diabetes develops high blood sugar levels... more...

Related Diseases for Gestational Diabetes

Diseases related to Gestational Diabetes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 maturity-onset diabetes of the young, type 2 31.8 GCK INS
2 fetal macrosomia 30.9 INS INSR LEP
3 diabetes mellitus 30.8 ADIPOQ ADRB3 GCK HKDC1 INS INSR
4 polycystic ovary syndrome 30.6 INS INSR IRS1 LEP SHBG
5 hypoglycemia 30.4 GCK INS INSR KCNJ11
6 sleep apnea 30.4 ADIPOQ INS LEP
7 hyperglycemia 30.3 ADIPOQ GCK INS INSR IRS1 KCNJ11
8 monogenic diabetes 30.2 GCK INS KCNJ11
9 maturity-onset diabetes of the young 30.1 GCK INS IRS1 KCNJ11
10 lipid metabolism disorder 30.1 ADIPOQ INS LEP RBP4 RETN
11 glucose intolerance 30.0 ADIPOQ ADRB3 GCK INS INSR IRS1
12 hyperinsulinism 29.9 GCK INS INSR KCNJ11 LEP SHBG
13 nonalcoholic steatohepatitis 29.9 ADIPOQ INS LEP
14 nonalcoholic fatty liver disease 29.9 ADIPOQ INS LEP RBP4 RETN
15 diabetes mellitus, insulin-dependent 29.9 GCK INS LEP PTPRN
16 severe pre-eclampsia 29.8 ADIPOQ LEP RBP4
17 acanthosis nigricans 29.8 ADIPOQ INS INSR LEP SHBG
18 fatty liver disease, nonalcoholic 1 29.8 ADIPOQ INS LEP RETN
19 hyperinsulinemic hypoglycemia 29.7 GCK INS INSR KCNJ11
20 morbid obesity 29.6 ADIPOQ ADRB3 INS LEP RETN
21 overnutrition 29.1 ADIPOQ ADRB3 INS IRS1 LEP NAMPT
22 fatty liver disease 29.1 ADIPOQ ADIPOR1 INS INSR IRS1 IRS2
23 glucose metabolism disease 28.3 ADIPOQ GCK INS IRS1 IRS2 KCNJ11
24 body mass index quantitative trait locus 11 28.1 ADIPOQ ADIPOR1 ADRB3 GCK INS INSR
25 diabetes mellitus, noninsulin-dependent 28.1 ADIPOQ ADIPOR1 ADRB3 GCK INS INSR
26 gestational diabetes insipidus 12.3
27 congenital anomalies of kidney and urinary tract 2 11.0
28 diabetes mellitus, transient neonatal, 3 11.0
29 pre-eclampsia 10.4
30 body mass index quantitative trait locus 1 10.3
31 eclampsia 10.3
32 pancreas disease 10.3 INS KCNJ11 LEP
33 munchausen by proxy 10.3 GCK KCNJ11
34 diabetes insipidus 10.3
35 lipodystrophy, congenital generalized, type 1 10.2 ADIPOQ INS LEP
36 acute insulin response 10.2 INS KCNJ11 TCF7L2
37 apnea, obstructive sleep 10.2 ADIPOQ INS LEP
38 alstrom syndrome 10.2 INS KCNJ11 LEP
39 pancreatic agenesis 10.2 GCK INS KCNJ11
40 lipodystrophy, familial partial, type 1 10.2 INS LEP
41 inherited metabolic disorder 10.2 ADIPOQ INS LEP
42 obesity-hypoventilation syndrome 10.2 ADIPOQ LEP RETN
43 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.2 INS INSR
44 coronary artery aneurysm 10.2 ADIPOQ LEP RETN
45 diabetes mellitus, permanent neonatal 10.2 GCK INS KCNJ11
46 arteries, anomalies of 10.2 ADIPOQ INS LEP
47 anovulation 10.2 INS LEP SHBG
48 prediabetes syndrome 10.2 ADIPOQ INS LEP TCF7L2
49 uremia 10.2 INS LEP RETN
50 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.2 ADIPOQ INS

Graphical network of the top 20 diseases related to Gestational Diabetes:



Diseases related to Gestational Diabetes

Symptoms & Phenotypes for Gestational Diabetes

UMLS symptoms related to Gestational Diabetes:


hyperemesis gravidarum, pelvic pain, morning sickness

GenomeRNAi Phenotypes related to Gestational Diabetes according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.25 IRS2
2 Decreased viability GR00173-A 10.25 PTPRN
3 Decreased viability GR00221-A-1 10.25 GCK INSR IRS1
4 Decreased viability GR00221-A-2 10.25 GCK INSR IRS1
5 Decreased viability GR00221-A-3 10.25 GCK INSR
6 Decreased viability GR00221-A-4 10.25 GCK INSR
7 Decreased viability GR00231-A 10.25 GCK
8 Decreased viability GR00342-S-2 10.25 IRS1
9 Decreased viability GR00342-S-3 10.25 IRS1
10 Decreased viability GR00381-A-1 10.25 ADRB3 RBP4
11 Decreased viability GR00381-A-2 10.25 RBP4
12 Decreased viability GR00381-A-3 10.25 RBP4
13 Decreased viability GR00402-S-2 10.25 ADIPOQ ADIPOR1 ADRB3 GCK HKDC1 INS
14 no effect GR00402-S-1 9.62 ADIPOQ ADIPOR1 ADRB3 GCK HKDC1 INS

MGI Mouse Phenotypes related to Gestational Diabetes:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.38 ADIPOQ ADIPOR1 ADRB3 GCK HKDC1 INS
2 adipose tissue MP:0005375 10.32 ADIPOQ ADIPOR1 ADRB3 INS INSR IRS1
3 growth/size/body region MP:0005378 10.31 ADIPOQ ADIPOR1 ADRB3 GCK INS INSR
4 endocrine/exocrine gland MP:0005379 10.3 ADIPOQ ADRB3 GCK INS INSR IRS1
5 cardiovascular system MP:0005385 10.26 ADIPOQ INS INSR IRS1 IRS2 KCNJ11
6 behavior/neurological MP:0005386 10.19 ADIPOQ ADIPOR1 ADRB3 INS INSR IRS2
7 immune system MP:0005387 10.11 ADIPOQ INS INSR IRS1 IRS2 LEP
8 liver/biliary system MP:0005370 10.1 ADIPOQ ADIPOR1 GCK HKDC1 INS INSR
9 mortality/aging MP:0010768 10.03 ADIPOQ GCK HKDC1 INS INSR IRS1
10 muscle MP:0005369 9.9 ADIPOQ ADIPOR1 INS INSR IRS1 IRS2
11 renal/urinary system MP:0005367 9.56 ADIPOQ GCK INS INSR IRS2 LEP
12 skeleton MP:0005390 9.28 ADIPOQ ADIPOR1 INS IRS1 LEP PAPPA

Drugs & Therapeutics for Gestational Diabetes

PubMedHealth treatment related to Gestational Diabetes: 63

A change in diet is usually enough to make the levels return to normal. Women with gestational diabetes can get advice from their doctor. Special dietary counseling can be helpful too. Another way to lower your blood sugar levels is by getting more exercise. In some pregnant women the blood sugar levels stay high for so long that they have to inject insulin or, in rare cases, take medicine for diabetes.The doctor will offer to measure the woman’s blood sugar levels again after the baby is born. If her blood sugar levels have returned to normal, no more treatment is needed.

Drugs for Gestational Diabetes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 289)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 657-24-9 14219 4091
2
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
3
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-66-6
4
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Not Applicable 116094-23-6 16132418
5
Glyburide Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 10238-21-8 3488
6
leucovorin Approved Phase 4,Phase 2,Phase 3,Not Applicable 58-05-9 6006 143
7
Silicon Approved, Investigational Phase 4 7440-21-3 4082203
8
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
9
Cyproterone Acetate Approved, Investigational Phase 4 427-51-0
10
Polyestradiol phosphate Approved Phase 4 28014-46-2
11 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
12
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
13
Insulin Lispro Approved Phase 4,Phase 2,Not Applicable 133107-64-9
14
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
15
Liraglutide Approved Phase 4,Phase 3 204656-20-2 44147092
16
Exenatide Approved, Investigational Phase 4,Not Applicable 141758-74-9 15991534
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 59-30-3 6037
18
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 67-97-0 5280795 6221
19
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 1406-16-2
20
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 50-14-6 5280793
21
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
22
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
23 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
25 insulin Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
26 Insulin, Globin Zinc Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
27 Analgesics, Non-Narcotic Phase 4,Phase 3
28 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
29 Antioxidants Phase 4,Phase 2,Phase 3,Not Applicable
30 Antirheumatic Agents Phase 4,Phase 3,Phase 2
31 Analgesics Phase 4,Phase 3
32 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
33 Antineoplastic Agents, Phytogenic Phase 4
34 Platelet Aggregation Inhibitors Phase 4,Phase 3
35 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
36 Pharmaceutical Solutions Phase 4,Not Applicable
37 Vitamins Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
38 Vitamin B9 Phase 4,Phase 2,Phase 3,Not Applicable
39 Vitamin B Complex Phase 4,Phase 2,Phase 3,Not Applicable
40 Micronutrients Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
41 Folate Phase 4,Phase 2,Phase 3,Not Applicable
42 Hematinics Phase 4,Phase 2,Phase 3,Not Applicable
43 Trace Elements Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
44 Bifidobacterium Phase 4,Not Applicable
45 Acidophilus Phase 4,Phase 3,Not Applicable
46 Sulfalene Phase 4
47 Estradiol 17 beta-cypionate Phase 4
48 Estradiol 3-benzoate Phase 4
49 Cyproterone acetate, ethinyl estradiol drug combination Phase 4
50 Contraceptive Agents, Male Phase 4

Interventional clinical trials:

(show top 50) (show all 600)
# Name Status NCT ID Phase Drugs
1 Preventing Recurrent Gestational Diabetes With Metformin Unknown status NCT02394158 Phase 4 Metformin;placebo
2 Can Resveratrol Improve Insulin Sensitivity and Preserve Beta Cell Function Following Gestational Diabetes? Unknown status NCT01997762 Phase 4
3 Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial Unknown status NCT02590016 Phase 4 Insulin, Aspart
4 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4 Metformin
5 Prevention of Diabetes Mellitus Development in Women Who Had Already Experienced A Gestational Diabetes Unknown status NCT00265746 Phase 4 Metformin
6 Oral Antidiabetic Agents in Pregnancy Unknown status NCT02091336 Phase 4 Metformin;Glyburide
7 Efficacy of Myo-inositol in Preventing Gestational Diabetes in High-risk Pregnant Women Unknown status NCT01511835 Phase 4 Folic Acid
8 Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia Unknown status NCT01718340 Phase 4 Metformin
9 Effect of Probiotics (Vivomixx®) on Weight, Microbiota and Glucose Tolerance in Obese Pregnant Women and Their Newborn Unknown status NCT02508844 Phase 4
10 the Effect of Diane-35 Pretreatment on In-vitro Fertilization Outcome for Patients With Polycystic Ovary Syndrome Unknown status NCT01752270 Phase 4 Diane-35 pretreatment;Diane-35 pretreatment
11 Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome Unknown status NCT01366391 Phase 4 Metformin
12 Probiotics in Newly Recognized Type 1 Diabetes Unknown status NCT03032354 Phase 4 Lactobacillus rhamnosus GG and Bifidobacterium lactis BB12
13 A Trial to Study the Effect of Long Term Vitamin D Supplementation on Insulin Sensitivity Unknown status NCT01052181 Phase 4 Cholecalciferol;placebo
14 Antioxidants in Gestational Diabetes Completed NCT02355197 Phase 4 L-ascorbic acid
15 Metformin Versus Insulin in Gestational Diabetes Completed NCT01240785 Phase 4 metformin;insulin
16 Medical Nutrition Therapy Plus Transgestational Metformin For Preventing Gestational Diabetes In High Risk Mexican Women Completed NCT01675310 Phase 4 medical nutrition therapy + metformin
17 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4 Glyburide;Placebo
18 Humalog® Mix50/50(tm) as a Treatment for Gestational Diabetes Completed NCT01613807 Phase 4 Insulin LISPRO;Insulin, Long-Acting and Insulin LISPRO
19 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4 metformin;glybenclamide
20 Metformin Postpartum for GDM RCT for Reduced Weight Retention Completed NCT01280409 Phase 4 Metformin;Placebo
21 Sitagliptin + Metformin Compared to Metformin Monotherapy and Placebo in Women With a Recent GDM Completed NCT01856907 Phase 4 Sitagliptin-Metformin;Metformin;Placebo pill
22 Resistance Exercise Training During Pregnancy: a Randomized Controlled Trial Completed NCT00813657 Phase 4
23 Efficacy of Corifollitropin Alfa Versus Follitropin Beta in Aged IVF (In-vitro Fertilization) Patients Completed NCT02466204 Phase 4 corifollitropin alfa;Follitropin Beta
24 The Safety of Anti-viral Therapy in Preventing HBV MTCT in Pregnant Women After Discontinuation Completed NCT03468907 Phase 4 Telbivudine 600mg;Tenofovir disoproxil fumarate 300mg
25 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Boostrix™ Vaccine in Pregnant Women Completed NCT02377349 Phase 4 Saline placebo
26 Metabolic Analysis for Treatment Choice in Gestational Diabetes Mellitus Recruiting NCT03029702 Phase 4 Insulin;Glyburide;Metformin
27 ZIMBA: Clinical Trial in Paediatric Obesity Recruiting NCT03283813 Phase 4 Placebos;Myoinositol
28 Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology Recruiting NCT03177122 Phase 4 Myo-inositol
29 The Impact of Liraglutide on Glucose Tolerance and the Risk of Type 2 Diabetes in Women With Previous Pregnancy-induced Diabetes Active, not recruiting NCT01795248 Phase 4 Liraglutide;Placebo
30 The Impact of Vitamin D Supplementation on Glucose Metabolism in Chinese Women With Former Gestational Diabetes Mellitus Enrolling by invitation NCT03138616 Phase 4 vitamin D
31 Threshold for Initiation of Medical Treatment for Women With Gestational Diabetes Not yet recruiting NCT03527537 Phase 4 Insulin;Glyburide;Metformin
32 Insulin Fiasp During Pregnancy and Laction in Women With Pre-existing Diabetes Not yet recruiting NCT03770767 Phase 4 Faster-acting Aspart insulin Fiasp;Control (insulin Novorapid or insulin Lispro)
33 Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus Not yet recruiting NCT03570632 Phase 4 Metformin
34 The Effectiveness and Safety of the Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation Not yet recruiting NCT03809221 Phase 4 Triptorelin acetate
35 Glyburide Compared to Insulin in the Management of White's Classification A2 Gestational Diabetes Withdrawn NCT00160485 Phase 4 Glyburide;Insulin
36 Pilot Study of Exenatide Pharmacokinetics and Pharmacodynamics in Gestational Diabetes Withdrawn NCT00572689 Phase 4 Exenatide
37 Glycemic Profile in Women With Gestational Diabetes Treated With Glyburide Withdrawn NCT01947699 Phase 4 Glyburide
38 Failure Rate of GLyburide And Metformin Among Gestational Diabetics Withdrawn NCT03078725 Phase 4 Glyburide;Metformin
39 Medico-GDM Trial - Metformine to Prevent Gestational Diabetes Mellitus Unknown status NCT02275845 Phase 3 Metformin
40 Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country Unknown status NCT01855763 Phase 2, Phase 3 Metformin;Insulin
41 Metformin for Prevention Gestational Diabetes in Pregnant Women With Polycystic Ovarian Syndrome Unknown status NCT02802215 Phase 2, Phase 3 metformin;placebo (folic acid )
42 Metformin for the Treatment of Diabetes in Pregnancy Unknown status NCT00414245 Phase 3 metformin
43 Modulation of the Intestinal Flora With the Probiotic VIVOMIXX™ in Pregnant Women at Risk of Metabolic Complications Unknown status NCT02768818 Phase 3
44 Probiotics (Lactobacillus Rhamnosus) in Reducing Glucose Intolerance During and After Pregnancy Unknown status NCT01436448 Phase 3 Probiotics Lactobacillus Rhamnosus
45 A Randomized Clinical Trial of Oral Magnesium Supplementation in Pregnancy Unknown status NCT02032186 Phase 3 Magnesium citrate
46 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Unknown status NCT02336243 Phase 3
47 Metformin Versus Insulin in the Treatment of Gestational Diabetes Mellitus Completed NCT01087866 Phase 2, Phase 3 Metformin;Insulin
48 Gestational Diabetes: Insulin or Oral Hypoglycemic Agents? Completed NCT01215331 Phase 3 Insulin;Metformin, glyburide and insulin
49 Comparison of Metformin and Insulin for Management of Gestational Diabetes Mellitus Completed NCT03320694 Phase 3 Metformin;Insulin
50 Multicenter Randomized Trial of Non-inferiority Between Glyburide and Insulin for the Treatment of Gestational Diabetes Completed NCT01731431 Phase 3 Glyburide

Search NIH Clinical Center for Gestational Diabetes

Cochrane evidence based reviews: diabetes, gestational

Genetic Tests for Gestational Diabetes

Anatomical Context for Gestational Diabetes

MalaCards organs/tissues related to Gestational Diabetes:

41
Testes, Placenta, Ovary, Liver, Endothelial, Breast, Heart

Publications for Gestational Diabetes

Articles related to Gestational Diabetes:

(show top 50) (show all 2650)
# Title Authors Year
1
A randomized controlled trial of a web-based education intervention for women with gestational diabetes mellitus. ( 30343264 )
2019
2
Association between early introduction of fruit juice during infancy and childhood consumption of sweet-tasting foods and beverages among children exposed and unexposed to gestational diabetes mellitus in utero. ( 30171916 )
2019
3
Pregnancy and post-partum muscle and cerebral oxygenation during intermittent exercise in gestational diabetes: A pilot study. ( 30468984 )
2019
4
Interactions among insulin resistance, inflammation factors, obesity-related gene polymorphisms, environmental risk factors, and diet in the development of gestational diabetes mellitus. ( 29519182 )
2019
5
Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation. ( 29149816 )
2019
6
A retrospective study comparing outcomes in a midwestern US population after introduction of IADPSG guidelines for gestational diabetes. ( 28835142 )
2019
7
Metabolic effects of breastfeeding in women with previous gestational diabetes diagnosed according to the IADPSG criteria. ( 28877616 )
2019
8
Maternal lipids, BMI and IL-17/IL-35 imbalance in concurrent gestational diabetes mellitus and preeclampsia. ( 29977366 )
2018
9
Hemoglobin levels during the first trimester of pregnancy are associated with the risk of gestational diabetes mellitus, pre-eclampsia and preterm birth in Chinese women: a retrospective study. ( 29940874 )
2018
10
Postpartum risk of diabetes and predictive factors for glucose intolerance in East Asian women with gestational diabetes. ( 29596944 )
2018
11
Recent gestational diabetes was associated with mothers stopping predominant breastfeeding earlier in a multi-ethnic population. ( 29432660 )
2018
12
Barriers to a healthy lifestyle for three- to four-year-old children of Australian-born and overseas-born mothers with post-gestational diabetes: An Australian qualitative study. ( 29444583 )
2018
13
Type 2 Diabetes after Gestational diabetes: Can the progression be prevented? ( 29430798 )
2018
14
History of mood or anxiety disorders and risk of gestational diabetes mellitus in a population-based cohort. ( 29120506 )
2018
15
Maternal gestational diabetes mellitus: is it associated with long-term pediatric ophthalmic morbidity of the offspring? ( 29429374 )
2018
16
A Cautionary Response to SMFM Statement: Pharmacological Treatment of Gestational Diabetes. ( 29959933 )
2018
17
Hyperlipidemia during gestational diabetes and its relation with maternal and offspring complications. ( 29974782 )
2018
18
Inflammatory Markers in Older Women with a History of Gestational Diabetes and the Effects of Weight Loss. ( 29951553 )
2018
19
Level of maternal triglycerides is a predictor of fetal macrosomia in non-obese pregnant women with gestational diabetes mellitus. ( 29398554 )
2018
20
Association between chemerin rs17173608 and rs4721 gene polymorphisms and gestational diabetes mellitus in Iranian pregnant women. ( 29360607 )
2018
21
Screening for gestational diabetes in low-risk women: effect of maternal age. ( 29425107 )
2018
22
Exploration of predictive metabolic factors for gestational diabetes mellitus in Japanese women using metabolomic analysis. ( 29956893 )
2018
23
Analysis of the correlation of gestational diabetes mellitus and peripheral ferritin with iron levels in early pregnancy. ( 29442476 )
2018
24
Metformin or insulin: logical treatment in women with gestational diabetes in the Middle East, our experience. ( 29970197 )
2018
25
Calcium Channel Blockers as Drug Repurposing Candidates for Gestational Diabetes: Mining large scale genomic and electronic health records data to repurpose medications. ( 29448118 )
2018
26
Circulating B-type natriuretic peptide in women with and without recent gestational diabetes: The impact of current glucose intolerance. ( 29112786 )
2018
27
The Impact of Health Locus of Control and Anxiety on Self-Monitored Blood Glucose Concentration in Women with Gestational Diabetes Mellitus. ( 28829663 )
2018
28
The Impact of Prepregnancy Body Mass Index and Gestational Weight Gain on Perinatal Outcomes for Women With Gestational Diabetes Mellitus. ( 29962105 )
2018
29
A nested case-control study of the association between exposure to polybrominated diphenyl ethers and the risk of gestational diabetes mellitus. ( 29980046 )
2018
30
Cadmium Body Burden and Gestational Diabetes Mellitus: A Prospective Study. ( 29425094 )
2018
31
Evidence for the utility of antenatal HbA1c to predict early postpartum diabetes after gestational diabetes in South Africa. ( 29969724 )
2018
32
Effects of Vitamin D Deficiency on Incidence Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis. ( 29449829 )
2018
33
Daily walking is effective for the management of pregnant women with gestational diabetes mellitus. ( 29974564 )
2018
34
Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: A population-based cohort study. ( 29337985 )
2018
35
A retrospective study of supplemental iron intake in singleton pregnancy women with risk of developing gestational diabetes mellitus. ( 29952938 )
2018
36
The impact of a daily smartphone-based feedback system among women with gestational diabetes on compliance, glycemic control, satisfaction, and pregnancy outcome: a randomized controlled trial. ( 29425836 )
2018
37
Combination of first trimester serum afamin levels and three-dimensional placental bed vascularization as a possible screening method to detect women at-risk for adverse pregnancy complications like pre-eclampsia and gestational diabetes mellitus in low-risk pregnancies. ( 29405972 )
2018
38
Therapies for gestational diabetes and their implications for maternal and offspring health: Evidence from human and animal studies. ( 29421161 )
2018
39
Factors predicting early postpartum glucose intolerance in Japanese women with gestational diabetes mellitus: decision-curve analysis. ( 29706019 )
2018
40
A case-control study and meta-analysis confirm glucokinase regulatory gene rs780094 is a risk factor for gestational diabetes mellitus. ( 29410004 )
2018
41
Temporal changes in characteristics and outcomes among pregnant women with pre-gestational diabetes. ( 29978470 )
2018
42
Effectiveness of a diabetes prevention program for rural women with prior gestational diabetes mellitus: study protocol of a multi-site randomized clinical trial. ( 29954367 )
2018
43
Correlation between plasma ferritin level and gestational diabetes mellitus and its impact on fetal macrosomia. ( 29542249 )
2018
44
Is Chemerin associated with gestational diabetes mellitus? An evidence-based clinical research from Chinese women. ( 29430984 )
2018
45
Urinary Inorganic Arsenic Concentration and Gestational Diabetes Mellitus in Pregnant Women from Arica, Chile. ( 29976896 )
2018
46
Evaluation of the diabetes in pregnancy study group of India criteria and Carpenter-Coustan criteria in the diagnosis of gestational diabetes mellitus. ( 29971182 )
2018
47
Fatty acid-binding protein 4 predicts gestational hypertension and preeclampsia in women with gestational diabetes mellitus. ( 29394285 )
2018
48
Incidence and risk factors for gestational diabetes mellitus in twin versus singleton pregnancies. ( 29971559 )
2018
49
Effect of gestational diabetes and hypertensive disorders of pregnancy on postpartum cardiometabolic risk. ( 29444890 )
2018
50
HBsAg positivity during pregnancy and risk of gestational diabetes mellitus: a systematic review and meta-analysis. ( 29968379 )
2018

Variations for Gestational Diabetes

Expression for Gestational Diabetes

Search GEO for disease gene expression data for Gestational Diabetes.

Pathways for Gestational Diabetes

Pathways related to Gestational Diabetes according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 ADIPOQ ADIPOR1 ADRB3 INS INSR IRS1
2
Show member pathways
12.86 GCK HKDC1 INS INSR IRS1 IRS2
3
Show member pathways
12.72 INS INSR IRS1 IRS2 SLC2A4
4
Show member pathways
12.65 ADRB3 INS INSR IRS1 IRS2
5
Show member pathways
12.63 ADIPOQ INS INSR IRS1 IRS2 LEP
6 12.51 ADIPOQ INS INSR IRS1 IRS2 NAMPT
7
Show member pathways
12.46 INS INSR IRS1 IRS2 SLC2A4
8
Show member pathways
12.43 GCK INS IRS1 IRS2 LEP
9
Show member pathways
12.34 ADIPOQ ADIPOR1 INS INSR IRS1 IRS2
10
Show member pathways
12.29 ADIPOQ ADIPOR1 INS KCNJ11
11
Show member pathways
12.21 INS INSR IRS1 IRS2 LEP SLC2A4
12
Show member pathways
12.11 ADIPOQ ADIPOR1 INS INSR IRS1 IRS2
13
Show member pathways
12.06 INS INSR IRS1 IRS2 SLC2A4
14
Show member pathways
11.95 INS INSR IRS1 IRS2 SLC2A4
15 11.88 INSR IRS1 TCF7L2
16 11.88 ADIPOQ INS IRS1 IRS2 LEP NAMPT
17 11.81 HKDC1 INS INSR
18 11.68 ADIPOQ ADIPOR1 IRS1 IRS2 LEP SLC2A4
19 11.61 INS INSR IRS1
20 11.56 ADRB3 INS INSR IRS1 IRS2
21 11.54 INS INSR IRS1 LEP
22 11.52 IRS1 IRS2 KCNJ11 LEP SLC2A4
23 11.42 GCK INS KCNJ11
24 11.41 INS INSR IRS1
25 11.34 INS INSR IRS1
26
Show member pathways
11.26 ADIPOQ GCK HKDC1 INS INSR IRS1
27 11.21 INS INSR SLC2A4
28
Show member pathways
10.94 INSR IRS1 SLC2A4
29 10.85 INS SLC2A4
30 10.78 ADIPOQ INSR IRS1 IRS2 LEP SLC2A4

GO Terms for Gestational Diabetes

Cellular components related to Gestational Diabetes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor complex GO:0005899 8.62 INSR IRS1

Biological processes related to Gestational Diabetes according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.93 ADRB3 GCK HKDC1 INS INSR SLC2A4
2 positive regulation of protein kinase B signaling GO:0051897 9.88 INS INSR IRS1 IRS2 LEP TCF7L2
3 positive regulation of MAPK cascade GO:0043410 9.87 ADRB3 INS INSR LEP
4 response to ethanol GO:0045471 9.85 ADIPOQ LEP RBP4 SLC2A4
5 positive regulation of cold-induced thermogenesis GO:0120162 9.84 ADIPOQ ADIPOR1 ADRB3 LEP
6 female pregnancy GO:0007565 9.83 LEP NAMPT PAPPA
7 circadian rhythm GO:0007623 9.83 ADIPOQ LEP NAMPT
8 response to glucose GO:0009749 9.83 ADIPOQ IRS2 PTPRN TCF7L2
9 insulin receptor signaling pathway GO:0008286 9.83 INS INSR IRS1 IRS2 NAMPT
10 response to insulin GO:0032868 9.81 IRS1 LEP PTPRN RETN
11 cellular response to insulin stimulus GO:0032869 9.8 ADIPOQ GCK INSR IRS1 IRS2 SLC2A4
12 regulation of insulin secretion GO:0050796 9.78 GCK KCNJ11 LEP
13 positive regulation of insulin secretion GO:0032024 9.78 GCK IRS2 RBP4 TCF7L2
14 cellular response to glucose stimulus GO:0071333 9.77 IRS2 KCNJ11 SLC29A1
15 cellular glucose homeostasis GO:0001678 9.67 GCK HKDC1
16 positive regulation of cellular protein metabolic process GO:0032270 9.67 ADIPOQ INS
17 negative regulation of gluconeogenesis GO:0045721 9.67 ADIPOQ GCK INS
18 positive regulation of insulin receptor signaling pathway GO:0046628 9.67 ADIPOR1 INS IRS1 LEP
19 fatty acid oxidation GO:0019395 9.66 ADIPOQ ADIPOR1
20 energy reserve metabolic process GO:0006112 9.66 ADRB3 LEP
21 cellular response to leptin stimulus GO:0044320 9.65 GCK LEP
22 positive regulation of glucose import GO:0046326 9.65 ADIPOQ INS INSR IRS1 IRS2
23 glucose 6-phosphate metabolic process GO:0051156 9.64 GCK HKDC1
24 neuron projection maintenance GO:1990535 9.64 INS INSR
25 positive regulation of fatty acid beta-oxidation GO:0032000 9.63 IRS1 IRS2
26 positive regulation of glucose metabolic process GO:0010907 9.63 IRS1 IRS2
27 glucose metabolic process GO:0006006 9.63 ADIPOQ GCK INS IRS2 KCNJ11 LEP
28 regulation of fatty acid biosynthetic process GO:0042304 9.62 ADIPOQ ADIPOR1
29 leptin-mediated signaling pathway GO:0033210 9.62 ADIPOR1 LEP
30 negative regulation of feeding behavior GO:2000252 9.59 INS RETN
31 positive regulation of respiratory burst GO:0060267 9.58 INS INSR
32 positive regulation of developmental growth GO:0048639 9.58 INSR LEP
33 positive regulation of glycogen biosynthetic process GO:0045725 9.35 GCK INS INSR IRS1 IRS2
34 glucose homeostasis GO:0042593 9.32 ADIPOQ ADIPOR1 GCK INS INSR IRS1
35 positive regulation of cell proliferation GO:0008284 10.03 INS INSR IRS1 IRS2 LEP NAMPT
36 regulation of signaling receptor activity GO:0010469 10.01 ADIPOQ INS LEP NAMPT RETN

Molecular functions related to Gestational Diabetes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.56 ADIPOQ INS LEP RETN
2 glucose binding GO:0005536 9.46 GCK HKDC1
3 fructokinase activity GO:0008865 9.43 GCK HKDC1
4 glucokinase activity GO:0004340 9.4 GCK HKDC1
5 hexokinase activity GO:0004396 9.37 GCK HKDC1
6 insulin receptor binding GO:0005158 9.33 INS IRS1 IRS2
7 mannokinase activity GO:0019158 9.32 GCK HKDC1
8 phosphatidylinositol 3-kinase binding GO:0043548 9.13 INSR IRS1 IRS2
9 insulin-like growth factor receptor binding GO:0005159 8.8 INS INSR IRS1

Sources for Gestational Diabetes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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