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MCID: GST010
MIFTS: 45

Gestational Trophoblastic Neoplasm

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Gestational Trophoblastic Neoplasm

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MalaCards integrated aliases for Gestational Trophoblastic Neoplasm:

Name: Gestational Trophoblastic Neoplasm 12 15
Hydatidiform Mole 12 44 73
Gestational Trophoblastic Disease 44 73
Gestational Trophoblastic Neoplasia 12
Gestational Trophoblastic Neoplasms 73
Hydatidiform Mole, Recurrent, 1 73
Molar Pregnancy 12

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Gestational Trophoblastic Neoplasm

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MalaCards based summary : Gestational Trophoblastic Neoplasm, also known as hydatidiform mole, is related to hydatidiform mole, recurrent, 1 and choriocarcinoma. An important gene associated with Gestational Trophoblastic Neoplasm is H19 (H19, Imprinted Maternally Expressed Transcript
LOI,deregulation of IGF2 promoters,and the altered expression levels of IGF2 and H19 genes might be associated with the progression of GTD.
Dysfunction Pattern: Expression [differentially expressed]), and among its related pathways/superpathways is Nucleotide-binding Oligomerization Domain (NOD) pathway. The drugs Nitroglycerin and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and placenta, and related phenotypes are spontaneous abortion and high maternal serum chorionic gonadotropin

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Related Diseases for Gestational Trophoblastic Neoplasm

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Diseases related to Gestational Trophoblastic Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 hydatidiform mole, recurrent, 1 31.6 CDKN1C H19 KHDC3L NLRP7 PHLDA2
2 choriocarcinoma 29.7 CSH1 CSH2 H19
3 trophoblastic neoplasm 28.7 CDKN1C CSH1 H19 KHDC3L NLRP2 NLRP7
4 gestational trophoblastic tumor 11.4
5 placental site trophoblastic tumor 11.2
6 partial hydatidiform mole 10.8 KHDC3L NLRP7
7 triploidy 10.7 KHDC3L NLRP7
8 hemihyperplasia, isolated 10.7 CDKN1C H19
9 umbilical hernia 10.6 CDKN1C H19
10 intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 10.5 CDKN1C NR0B1
11 gestational choriocarcinoma 10.5 CSH1 H19
12 pyle disease 10.4 CDKN1C NR0B1
13 silver-russell syndrome 10.3 CDKN1C CSH1 H19
14 wilms tumor 5 10.3 CDKN1C H19
15 diabetes mellitus, transient neonatal, 1 10.3 KHDC3L NLRP2 NLRP7
16 adrenocortical carcinoma, hereditary 10.3 CDKN1C H19 NR0B1
17 testicular trophoblastic tumor 10.0 CSH1 CSH2
18 choriocarcinoma of ovary 10.0 CSH1 CSH2
19 testicular granulosa cell tumor 9.9 CSH1 CSH2
20 juvenile type testicular granulosa cell tumor 9.9 CSH1 CSH2
21 klippel-trenaunay-weber syndrome 9.9
22 pleurisy 9.9
23 hypothyroidism 9.9
24 epithelioid trophoblastic tumor 9.9
25 placenta accreta 9.9
26 non-gestational choriocarcinoma 9.9 CSH1 CSH2
27 choriocarcinoma of the testis 9.9 CSH1 CSH2
28 rh isoimmunization 9.8 CSH1 CSH2
29 chronic salpingitis 9.7 CSH1 CSH2
30 beckwith-wiedemann syndrome 9.7 CDKN1C H19 NLRP2 PHLDA2
31 uterine anomalies 9.7 CSH1 CSH2
32 placenta disease 9.5 CSH1 CSH2
33 female reproductive system disease 9.2 CSH1 CSH2
34 germ cell and embryonal cancer 8.1 CDKN1C CSH1 CSH2 KHDC3L LGALS1 NLRP7

Graphical network of the top 20 diseases related to Gestational Trophoblastic Neoplasm:



Diseases related to Gestational Trophoblastic Neoplasm
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Symptoms & Phenotypes for Gestational Trophoblastic Neoplasm

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Human phenotypes related to Gestational Trophoblastic Neoplasm:

32
# Description HPO Frequency HPO Source Accession
1 spontaneous abortion 32 hallmark (90%) HP:0005268
2 high maternal serum chorionic gonadotropin 32 hallmark (90%) HP:0011433
3 menometrorrhagia 32 hallmark (90%) HP:0400008
Sources

Drugs & Therapeutics for Gestational Trophoblastic Neoplasm

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Drugs for Gestational Trophoblastic Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 178)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitroglycerin Approved, Investigational Phase 4,Phase 2 55-63-0 4510
2 Vaccines Phase 4,Phase 3,Phase 1
3
Levoleucovorin Approved, Investigational Phase 2, Phase 3,Phase 3 68538-85-2
4
Methotrexate Approved Phase 2, Phase 3,Phase 3 1959-05-2, 59-05-2 126941
5
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 2019 457193
6
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
7
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
8
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
9
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 22916-47-8 4189
10
Captopril Approved Phase 3 62571-86-2 44093
11
Cyclophosphamide Approved, Investigational Phase 3,Not Applicable 50-18-0, 6055-19-2 2907
12
Palivizumab Approved, Investigational Phase 3 188039-54-5
13
Ribavirin Approved Phase 3 36791-04-5 37542
14
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
15
Itraconazole Approved, Investigational Phase 3,Not Applicable 84625-61-6 55283
16
Acyclovir Approved Phase 3 59277-89-3 2022
17
Carboplatin Approved Phase 3,Phase 1 41575-94-4 10339178 498142 38904
18
Etoposide Approved Phase 3,Phase 1 33419-42-0 36462
19
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
20
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
21
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
22
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
23 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
24
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
25
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
26
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
27
Polyestradiol phosphate Approved Phase 3 28014-46-2
28
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
29
Mycophenolic acid Approved Phase 3 24280-93-1 446541
30
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3,Not Applicable 59-30-3 6037
31
leucovorin Approved, Nutraceutical Phase 2, Phase 3,Phase 3,Not Applicable 58-05-9 143 6006
32 Antidotes Phase 2, Phase 3,Phase 3,Not Applicable
33 Antimetabolites Phase 2, Phase 3,Phase 3
34 Antimetabolites, Antineoplastic Phase 2, Phase 3,Phase 3
35 Antirheumatic Agents Phase 2, Phase 3,Phase 3,Not Applicable
36 Bone Density Conservation Agents Phase 2, Phase 3,Phase 3
37 Calcium, Dietary Phase 2, Phase 3,Phase 3,Not Applicable
38 Dermatologic Agents Phase 2, Phase 3,Phase 3,Not Applicable
39 Folic Acid Antagonists Phase 2, Phase 3,Phase 3
40 Hematinics Phase 2, Phase 3,Phase 3,Not Applicable
41 Immunosuppressive Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
42 Liver Extracts Phase 2, Phase 3,Phase 3,Phase 1
43 Micronutrients Phase 2, Phase 3,Phase 3,Not Applicable
44 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Phase 3
45 Protective Agents Phase 2, Phase 3,Phase 3,Not Applicable
46 Trace Elements Phase 2, Phase 3,Phase 3,Not Applicable
47 Vitamin B Complex Phase 2, Phase 3,Phase 3,Not Applicable
48 Vitamins Phase 2, Phase 3,Phase 3,Not Applicable
49 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable
50 Antibiotics, Antitubercular Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 82)
# Name Status NCT ID Phase Drugs
1 Effectiveness, Safety and Immunogenicity of GSK Biologicals' HPV Vaccine GSK580299 (Cervarix TM) Administered in Healthy Adolescents Completed NCT00534638 Phase 4
2 A Comparison of Single Versus Double Evacuation for Treatment of Hydatidiform Mole Recruiting NCT01630954 Phase 4
3 Surgery Plus Single Agent Chemotherapy Versus Primary Chemotherapy for Gestational Trophoblastic Neoplasms Unknown status NCT02606539 Phase 2, Phase 3 Methotrexate plus folinic acid alone
4 Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia Completed NCT00003702 Phase 3 Methotrexate
5 RCT on the Efficacy of Methotrexate for the Prevention of GTD Completed NCT01984099 Phase 3 Methotrexate;Vitamin B Complex
6 Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer Completed NCT00058071 Phase 3 amifostine trihydrate
7 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
8 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
9 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
10 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
11 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
12 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
13 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
14 Efficacy, Immunogenicity and Safety of GSK Biologicals' HPV GSK 580299 Vaccine in Healthy Chinese Female Subjects Completed NCT00779766 Phase 3
15 Human Papilloma Virus (HPV) Vaccine Efficacy Trial Against Cervical Pre-cancer in Young Adults With GlaxoSmithKline (GSK) Biologicals HPV-16/18 Completed NCT00122681 Phase 3
16 Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01823315 Phase 3 MTX 1;MTX 2
17 Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01535053 Phase 3 Leucovorin Calcium;Methotrexate
18 Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor Not yet recruiting NCT02639650 Phase 3 Etoposide;actinomycin D;methotrexate;vincristine;cyclophosphamide;Paclitaxel;Cisplatin;Carboplatin
19 Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia Not yet recruiting NCT03280979 Phase 2, Phase 3 rescue regimen;high dose methotrxate
20 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
21 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
22 Dactinomycin in Treating Patients With Persistent or Recurrent Gestational Trophoblastic Neoplasia Completed NCT00003688 Phase 2
23 A Trial for Patients With Gestational Trophoblastic Disease Completed NCT00190918 Phase 2 Pemetrexed
24 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
25 Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant Completed NCT00410657 Phase 2 methylprednisolone;prednisone
26 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
27 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
28 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
29 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
30 Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation Completed NCT00064311 Phase 1, Phase 2 ravuconazole
31 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
32 Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer Completed NCT01764802 Phase 2
33 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2 ondansetron
34 Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant Completed NCT00357084 Phase 2 methotrexate;methylprednisolone;prednisone
35 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
36 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
37 Avelumab in Chemo-resistant Gestational Trophoblastic Neoplasias Recruiting NCT03135769 Phase 2 Avelumab administration at 10mg/kg
38 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Recruiting NCT02664961 Phase 2 TRC105;Bevacizumab
39 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
40 Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Low-Risk Gestational Trophoblastic Tumor After a Molar Pregnancy Terminated NCT00096187 Phase 2 pemetrexed disodium
41 Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload Terminated NCT01159067 Phase 2 deferasirox
42 Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions Unknown status NCT00066404 Phase 1
43 Emergency Use of Donor Lymphocytes in Treating Patients Who Have Undergone Donor Stem Cell Transplant and Have Cytomegalovirus Infections Unknown status NCT00769613 Phase 1
44 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
45 Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia Completed NCT01484015 Phase 1 cefepime hydrochloride
46 Aminocamptothecin in Treating Patients With Advanced Cancer of the Peritoneal Cavity Completed NCT00003548 Phase 1 aminocamptothecin colloidal dispersion
47 Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors Completed NCT00003597 Phase 1 carboplatin;etoposide;ifosfamide
48 Donor Natural Killer Cell Infusion in Preventing Relapse or Graft Failure in Patients Who Have Undergone Donor Bone Marrow Transplant Completed NCT00569283 Phase 1
49 Vaccine Therapy in Treating Patients Who Have Undergone a Donor Stem Cell Transplant and Have Cytomegalovirus Infection That Has Not Responded to Therapy Completed NCT00509691 Phase 1
50 Donor Mesenchymal Stem Cell Infusion in Treating Patients With Acute or Chronic Graft-Versus-Host Disease After Undergoing a Donor Stem Cell Transplant Completed NCT00361049 Phase 1

Search NIH Clinical Center for Gestational Trophoblastic Neoplasm

Cochrane evidence based reviews: hydatidiform mole

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Genetic Tests for Gestational Trophoblastic Neoplasm

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Anatomical Context for Gestational Trophoblastic Neoplasm

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MalaCards organs/tissues related to Gestational Trophoblastic Neoplasm:

41
Bone, Bone Marrow, Placenta, Breast, Liver, Colon, T Cells
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Publications for Gestational Trophoblastic Neoplasm

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Articles related to Gestational Trophoblastic Neoplasm:

(show top 50) (show all 326)
# Title Authors Year
1
Clinical and genetic-epignetic aspects of recurrent hydatidiform mole: A review of literature. ( 29458875 )
2018
2
Hysteroscopic Management of Partial Hydatidiform Mole: A Novel Approach to an Old Disease. ( 29631009 )
2018
3
Choriocarcinoma with multiple lung metastases from complete hydatidiform mole with coexistent fetus during pregnancy. ( 29845692 )
2018
4
Is Ki-67 of Diagnostic Value in Distinguishing Between Partial and Complete Hydatidiform Moles? A Systematic Review and Meta-analysis. ( 29374747 )
2018
5
miR-21 Is Overexpressed in Hydatidiform Mole Tissues and Promotes Proliferation, Migration, and Invasion in Choriocarcinoma Cells. ( 27922982 )
2017
6
A pilot randomized controlled clinical trial of second uterine curettage versus usual care to determine the effect of re-curettage on patients' need for chemotherapy among women with low risk, nonmetastatic gestational trophoblastic neoplasm in Urmia, Iran. ( 29033610 )
2017
7
Role of P57KIP2 Immunohistochemical Expression in Histological Diagnosis of Hydatidiform Moles. ( 27221896 )
2016
8
Trends in ectopic pregnancy, hydatidiform mole and miscarriage in the largest obstetrics and gynaecology hospital in China from 2003 to 2013. ( 27206481 )
2016
9
Partial hydatidiform mole in a phenylketonuria patient treated with sapropterin dihydrochloride. ( 27898272 )
2016
10
Diginyc partial hydatidiform mole with increased fetal nuchal translucency and ovarian hyperstimulation syndrome. ( 27328519 )
2016
11
Two novel mutations in the KHDC3L gene in Asian patients with recurrent hydatidiform mole. ( 27621838 )
2016
12
Expression patterns of ERVWE1/Syncytin-1 and other placentally expressed human endogenous retroviruses along the malignant transformation process of hydatidiform moles. ( 26992684 )
2016
13
Unusual Presentation of Hypothyroidism in a Pregnant Woman, Mimicking Gestational Trophoblastic Neoplasm. ( 27034864 )
2016
14
E-Cadherin, CD44v6, and Insulin-Like Growth Factor-II mRNA-Binding Protein 3 Expressions in Different Stages of Hydatidiform Moles. ( 27238915 )
2016
15
Histological comparison of partial hydatidiform mole and trisomy gestation specimens. ( 27575970 )
2016
16
A Reappraisal of the Incidence of Placental Hydatidiform Mole Using Selective Molecular Genotyping. ( 27258730 )
2016
17
Solitary lung metastasis from gestational choriocarcinoma resected six years after hydatidiform mole: A case report. ( 27744215 )
2016
18
Clinical Presentation of Complete Hydatidiform Mole and Partial Hydatidiform Mole at a Regional Trophoblastic Disease Center in the United States Over the Past 2 Decades. ( 26588240 )
2016
19
Immunohistochemical Analysis of E-Cadherin, p53 and Inhibin-I+ Expression in Hydatidiform Mole and Hydropic Abortion. ( 26683836 )
2016
20
Medical termination of a partial hydatidiform mole and coexisting fetus during the second trimester: A case report. ( 26788180 )
2015
21
Live births in women with recurrent hydatidiform mole and two NLRP7 mutations. ( 25982095 )
2015
22
Gestational trophoblastic neoplasm and women living with HIV and/or AIDS. ( 29568578 )
2015
23
Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm. ( 26599757 )
2015
24
Absence of Maternal Methylation in Biparental Hydatidiform Moles from Women with NLRP7 Maternal-Effect Mutations Reveals Widespread Placenta-Specific Imprinting. ( 26544189 )
2015
25
Novel Nonsense Mutation in the NLRP7 Gene Associated with Recurrent Hydatidiform Mole. ( 26606510 )
2015
26
Trophoblast subtype-specific EGFR/ERBB4 expression correlates with cell cycle progression and hyperplasia in complete hydatidiform moles. ( 25740878 )
2015
27
[Diagnostic utility of STR genotyping for partial hydatidiform moles]. ( 26888503 )
2015
28
Partial hydatidiform mole with extensive angiomatoid vessel configuration in a first trimester miscarriage. ( 25844548 )
2015
29
Early Detection by Ultrasound of Partial Hydatidiform Mole With a Coexistent Live Fetus. ( 26726342 )
2015
30
NLRP7 and KHDC3L, the two maternal-effect proteins responsible for recurrent hydatidiform moles, co-localize to the oocyte cytoskeleton. ( 25358348 )
2015
31
Clinical utility of selective molecular genotyping for diagnosis of partial hydatidiform mole; a retrospective study from a regional trophoblastic disease unit. ( 25078332 )
2014
32
Partial hydatidiform mole following intracytoplasmic sperm injection and transfer of a cryopreserved-thawed blastocyst. ( 25093925 )
2014
33
Current clinical features of complete and partial hydatidiform mole in Sweden. ( 24597287 )
2014
34
Rare Case of Twin Pregnancy with Complete Hydatidiform Mole and Coexisting Fetus (CHMF) following Infertility Treatment. ( 25404812 )
2014
35
Utility of fluorescence in situ hybridization for ploidy and p57 immunostaining in discriminating hydatidiform moles. ( 24613849 )
2014
36
A well-circumscribed border with peripheral Doppler signal in sonographic image distinguishes epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. ( 25396428 )
2014
37
Characteristics of hydatidiform moles: analysis of a prospective series with p57 immunohistochemistry and molecular genotyping. ( 23887308 )
2014
38
Klippel-Trenaunay syndrome and gestational trophoblastic neoplasm. ( 25228614 )
2014
39
Rare case of peritoneal complete hydatidiform mole. ( 24428592 )
2014
40
In patients with neoplasia after partial hydatidiform mole immunohistochemistry or genotyping is essential to differentiate partial hydatidiform mole from complete mole, histologic examination is insufficient. ( 25340289 )
2014
41
Partial hydatidiform mole diagnosis in a cat: a case report. ( 23817014 )
2014
42
Novel NLRP7 mutations in familial recurrent hydatidiform mole: are NLRP7 mutations a risk for recurrent reproductive wastage? ( 23880596 )
2013
43
Placental expression of VEGF is increased in pregnancies with hydatidiform mole: possible association with developing very early onset preeclampsia. ( 23522390 )
2013
44
Mutations in NLRP7 and KHDC3L confer a complete hydatidiform mole phenotype on digynic triploid conceptions. ( 23125094 )
2013
45
Partial hydatidiform mole: histologic parameters in correlation with DNA genotyping. ( 23518914 )
2013
46
Partial hydatidiform mole and coexisting viable twin pregnancy. ( 24300477 )
2013
47
Pemphigoid gestationis after spontaneous expulsion of a massive complete hydatidiform mole. ( 24083041 )
2013
48
Ultrasonographic signs of partial hydatidiform mole. ( 23848045 )
2013
49
The impact of ultrasonographic lesion size and initial human chorionic gonadotropin values on treatment success in cases with complete hydatidiform mole. ( 24379071 )
2013
50
No evidence for mutations in NLRP7 and KHDC3L in women with androgenetic hydatidiform moles. ( 24105752 )
2013
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Variations for Gestational Trophoblastic Neoplasm

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Expression for Gestational Trophoblastic Neoplasm

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Search GEO for disease gene expression data for Gestational Trophoblastic Neoplasm.
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Pathways for Gestational Trophoblastic Neoplasm

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Pathways related to Gestational Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Nucleotide-binding Oligomerization Domain (NOD) pathway 1
10.24 NLRP2 NLRP7
Sources

GO Terms for Gestational Trophoblastic Neoplasm

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Biological processes related to Gestational Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.62 NLRP2 NLRP5 NLRP7 PHLDA2
2 negative regulation of inflammatory response GO:0050728 9.61 NLRP2 NLRP5 NLRP7
3 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.58 NLRP2 NLRP5 NLRP7
4 regulation of inflammatory response GO:0050727 9.54 NLRP2 NLRP5 NLRP7
5 positive regulation of interleukin-1 beta secretion GO:0050718 9.46 NLRP2 NLRP7
6 regulation of cytokine production GO:0001817 9.43 NLRP2 NLRP5 NLRP7
7 signaling GO:0023052 9.33 NLRP2 NLRP5 NLRP7
8 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.13 NLRP2 NLRP5 NLRP7
9 negative regulation of immune response GO:0050777 8.8 NLRP2 NLRP5 NLRP7
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Sources for Gestational Trophoblastic Neoplasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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