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MCID: GST010
MIFTS: 46

Gestational Trophoblastic Neoplasm

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Gestational Trophoblastic Neoplasm

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MalaCards integrated aliases for Gestational Trophoblastic Neoplasm:

Name: Gestational Trophoblastic Neoplasm 12 15
Hydatidiform Mole 12 44 15 73
Gestational Trophoblastic Disease 44 73
Gestational Trophoblastic Neoplasia 12
Gestational Trophoblastic Neoplasms 73
Hydatidiform Mole, Recurrent, 1 73
Molar Pregnancy 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Gestational Trophoblastic Neoplasm

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MalaCards based summary : Gestational Trophoblastic Neoplasm, also known as hydatidiform mole, is related to partial hydatidiform mole and hydatidiform mole, recurrent, 1. An important gene associated with Gestational Trophoblastic Neoplasm is H19 (H19, Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways is Nucleotide-binding Oligomerization Domain (NOD) pathway. The drugs Nitroglycerin and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include placenta, testes and lung, and related phenotypes are spontaneous abortion and menometrorrhagia

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Related Diseases for Gestational Trophoblastic Neoplasm

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Diseases related to Gestational Trophoblastic Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 partial hydatidiform mole 34.6 KHDC3L NLRP7
2 hydatidiform mole, recurrent, 1 32.3 CDKN1C H19 KHDC3L NLRP7 PHLDA2
3 choriocarcinoma 31.4 CSH1 CSH2 H19
4 triploidy 31.1 KHDC3L NLRP7
5 gestational choriocarcinoma 30.9 CSH1 H19
6 trophoblastic neoplasm 30.3 CDKN1C CSH1 H19 KHDC3L NLRP2 NLRP7
7 recurrent hydatidiform mole 12.9
8 hydatidiform mole, recurrent, 2 12.8
9 invasive mole 12.1
10 gestational trophoblastic tumor 11.5
11 placental site trophoblastic tumor 11.4
12 pulmonary arterio-veinous fistula 11.2
13 hyperthyroidism, familial gestational 11.0
14 hyperthyroidism 10.7
15 eclampsia 10.6
16 ectopic pregnancy 10.5
17 pre-eclampsia 10.4
18 placenta praevia 10.4
19 severe pre-eclampsia 10.4
20 herpes gestationis 10.3
21 infertility 10.3
22 anencephaly 10.2
23 choroideremia 10.2
24 ovarian hyperstimulation syndrome 10.2
25 pemphigus gestationis 10.2
26 thrombosis 10.2
27 endometritis 10.2
28 sarcoma 10.2
29 endometriosis of ovary 10.2
30 nephrotic syndrome 10.2
31 ulceration of vulva 10.2
32 acromegaly 10.2
33 endometriosis 10.2
34 arthropathy 10.2
35 dysgerminoma 10.2
36 ovarian cyst 10.2
37 adenoma 10.2
38 chromosomal triplication 10.2
39 pemphigoid gestationis 10.2
40 tetraploidy 10.2
41 hemihyperplasia, isolated 10.2 CDKN1C H19
42 intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies 10.1 CDKN1C NR0B1
43 umbilical hernia 10.1 CDKN1C H19
44 silver-russell syndrome 10.1 CDKN1C CSH1 H19
45 preeclampsia/eclampsia 1 10.1
46 diabetes mellitus, transient neonatal, 1 10.1 KHDC3L NLRP2 NLRP7
47 pyle disease 10.1 CDKN1C NR0B1
48 breast cancer 10.1
49 milia, multiple eruptive 10.1
50 pelger-huet anomaly 10.1

Graphical network of the top 20 diseases related to Gestational Trophoblastic Neoplasm:



Diseases related to Gestational Trophoblastic Neoplasm
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Symptoms & Phenotypes for Gestational Trophoblastic Neoplasm

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Human phenotypes related to Gestational Trophoblastic Neoplasm:

32
# Description HPO Frequency HPO Source Accession
1 spontaneous abortion 32 hallmark (90%) HP:0005268
2 menometrorrhagia 32 hallmark (90%) HP:0400008
3 high maternal serum chorionic gonadotropin 32 hallmark (90%) HP:0011433
Sources

Drugs & Therapeutics for Gestational Trophoblastic Neoplasm

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Drugs for Gestational Trophoblastic Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 171)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitroglycerin Approved, Investigational Phase 4,Phase 2 55-63-0 4510
2
Levoleucovorin Approved, Investigational Phase 2, Phase 3,Phase 3 68538-85-2
3
leucovorin Approved Phase 2, Phase 3,Phase 3 58-05-9 6006 143
4
Methotrexate Approved Phase 2, Phase 3,Phase 3 59-05-2, 1959-05-2 126941
5
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 457193 2019
6
Amifostine Approved, Investigational Phase 3 20537-88-6 2141
7
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
8
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
9
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Not Applicable 22916-47-8 4189
10
Cyclophosphamide Approved, Investigational Phase 3,Not Applicable 6055-19-2, 50-18-0 2907
11
Captopril Approved Phase 3 62571-86-2 44093
12
Ribavirin Approved Phase 3 36791-04-5 37542
13
Palivizumab Approved, Investigational Phase 3 188039-54-5
14
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
15
Itraconazole Approved, Investigational Phase 3,Not Applicable 84625-61-6 55283
16
Acyclovir Approved Phase 3 59277-89-3 2022
17
Carboplatin Approved Phase 3,Phase 1 41575-94-4 10339178 38904 498142
18
Etoposide Approved Phase 3,Phase 1 33419-42-0 36462
19
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
20
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
21
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
22
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
23
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
24 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
25
Polyestradiol phosphate Approved Phase 3 28014-46-2
26
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
27
Ethinyl Estradiol Approved Phase 3 57-63-6 5991
28
Mycophenolic acid Approved Phase 3 24280-93-1 446541
29
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3 59-30-3 6037
30 Bone Density Conservation Agents Phase 2, Phase 3,Phase 3
31 Micronutrients Phase 2, Phase 3,Phase 3
32 Immunosuppressive Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
33 Immunologic Factors Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
34 Vitamin B9 Phase 2, Phase 3,Phase 3
35 Vitamins Phase 2, Phase 3,Phase 3
36 Dermatologic Agents Phase 2, Phase 3,Phase 3,Not Applicable
37 Antimetabolites, Antineoplastic Phase 2, Phase 3,Phase 3
38 Vitamin B Complex Phase 2, Phase 3,Phase 3
39 Antirheumatic Agents Phase 2, Phase 3,Phase 3,Not Applicable
40 Liver Extracts Phase 2, Phase 3,Phase 3,Phase 1
41 Folic Acid Antagonists Phase 2, Phase 3,Phase 3
42 Antimetabolites Phase 2, Phase 3,Phase 3
43 Hematinics Phase 2, Phase 3,Phase 3
44 Folate Phase 2, Phase 3,Phase 3
45 Trace Elements Phase 2, Phase 3,Phase 3
46 Protective Agents Phase 2, Phase 3,Phase 3,Not Applicable
47 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Phase 3
48 Calcium, Dietary Phase 2, Phase 3,Phase 3,Not Applicable
49 Antidotes Phase 2, Phase 3,Phase 3,Not Applicable
50 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 76)
# Name Status NCT ID Phase Drugs
1 A Comparison of Single Versus Double Evacuation for Treatment of Hydatidiform Mole Recruiting NCT01630954 Phase 4
2 Surgery Plus Single Agent Chemotherapy Versus Primary Chemotherapy for Gestational Trophoblastic Neoplasms Unknown status NCT02606539 Phase 2, Phase 3 Methotrexate plus folinic acid alone
3 Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic Neoplasia Completed NCT00003702 Phase 3 Methotrexate
4 RCT on the Efficacy of Methotrexate for the Prevention of GTD Completed NCT01984099 Phase 3 Methotrexate;Vitamin B Complex
5 Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer Completed NCT00058071 Phase 3 amifostine trihydrate
6 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
7 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
8 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
9 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
10 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
11 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
12 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
13 Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor Recruiting NCT02639650 Phase 3 Etoposide;actinomycin D;methotrexate;vincristine;cyclophosphamide;Paclitaxel;Cisplatin;Carboplatin
14 Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01823315 Phase 3 MTX 1;MTX 2
15 Dactinomycin or Methotrexate in Treating Patients With Low-Risk Gestational Trophoblastic Neoplasia Active, not recruiting NCT01535053 Phase 3 Leucovorin Calcium;Methotrexate
16 Study of Hysteroscopic Repeat Curettage as the First-line Treatment in Low-risk Postmolar Gestational Trophoblastic Neoplasia Not yet recruiting NCT03703271 Phase 3 Methotrexate
17 Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia Not yet recruiting NCT03280979 Phase 2, Phase 3 rescue regimen;high dose methotrxate
18 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
19 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
20 Dactinomycin in Treating Patients With Persistent or Recurrent Gestational Trophoblastic Neoplasia Completed NCT00003688 Phase 2
21 A Trial for Patients With Gestational Trophoblastic Disease Completed NCT00190918 Phase 2 Pemetrexed
22 Second Curettage in Treating Patients With Persistent Non-metastatic Gestational Trophoblastic Tumors Completed NCT00521118 Phase 2
23 Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant Completed NCT00410657 Phase 2 methylprednisolone;prednisone
24 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
25 Campath-1H + FK506 and Methylprednisolone for GVHD Completed NCT00109993 Phase 2 methylprednisolone;tacrolimus
26 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
27 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
28 Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation Completed NCT00064311 Phase 1, Phase 2 ravuconazole
29 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
30 Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer Completed NCT01764802 Phase 2
31 Ondansetron in Preventing Nausea and Vomiting in Patients Undergoing Stem Cell Transplant Completed NCT00795769 Phase 2 ondansetron
32 Caspofungin Acetate in Treating Aspergillosis in Patients With Hematologic Cancer or in Patients Who Have Undergone a Stem Cell Transplant Completed NCT00110045 Phase 2 caspofungin acetate
33 Methotrexate and Glucocorticoids in Treating Patients With Newly Diagnosed Acute Graft-Versus-Host Disease After Donor Stem Cell Transplant Completed NCT00357084 Phase 2 methotrexate;methylprednisolone;prednisone
34 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
35 Avelumab in Chemo-resistant Gestational Trophoblastic Neoplasias Recruiting NCT03135769 Phase 2 Avelumab administration at 10mg/kg
36 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
37 Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Low-Risk Gestational Trophoblastic Tumor After a Molar Pregnancy Terminated NCT00096187 Phase 2 pemetrexed disodium
38 Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN) Terminated NCT02664961 Phase 2 TRC105;Bevacizumab
39 Deferasirox for Treating Patients Who Have Undergone Allogeneic Stem Cell Transplant and Have Iron Overload Terminated NCT01159067 Phase 2 deferasirox
40 Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions Unknown status NCT00066404 Phase 1
41 Emergency Use of Donor Lymphocytes in Treating Patients Who Have Undergone Donor Stem Cell Transplant and Have Cytomegalovirus Infections Unknown status NCT00769613 Phase 1
42 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
43 Prolonged or Standard Infusion of Cefepime Hydrochloride in Treating Patients With Febrile Neutropenia Completed NCT01484015 Phase 1 cefepime hydrochloride
44 Aminocamptothecin in Treating Patients With Advanced Cancer of the Peritoneal Cavity Completed NCT00003548 Phase 1 aminocamptothecin colloidal dispersion
45 Colony-Stimulating Factors in Treating Children With Recurrent or Refractory Solid Tumors Completed NCT00003597 Phase 1 carboplatin;etoposide;ifosfamide
46 Donor Natural Killer Cell Infusion in Preventing Relapse or Graft Failure in Patients Who Have Undergone Donor Bone Marrow Transplant Completed NCT00569283 Phase 1
47 Vaccine Therapy in Treating Patients Who Have Undergone a Donor Stem Cell Transplant and Have Cytomegalovirus Infection That Has Not Responded to Therapy Completed NCT00509691 Phase 1
48 Donor Mesenchymal Stem Cell Infusion in Treating Patients With Acute or Chronic Graft-Versus-Host Disease After Undergoing a Donor Stem Cell Transplant Completed NCT00361049 Phase 1
49 Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803 Recruiting NCT02890758 Phase 1
50 Detection of Human Chorionic Gonadotropin by Interferometry in Gestational Trophoblastic Disease Unknown status NCT00166790 chemotherapy agents

Search NIH Clinical Center for Gestational Trophoblastic Neoplasm

Cochrane evidence based reviews: hydatidiform mole

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Genetic Tests for Gestational Trophoblastic Neoplasm

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Anatomical Context for Gestational Trophoblastic Neoplasm

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MalaCards organs/tissues related to Gestational Trophoblastic Neoplasm:

41
Placenta, Testes, Lung, Thyroid, Liver, Uterus, Ovary
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Publications for Gestational Trophoblastic Neoplasm

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Articles related to Gestational Trophoblastic Neoplasm:

(show top 50) (show all 1042)
# Title Authors Year
1
Clinical and genetic-epignetic aspects of recurrent hydatidiform mole: A review of literature. ( 29458875 )
2018
2
Hysteroscopic Management of Partial Hydatidiform Mole: A Novel Approach to an Old Disease. ( 29631009 )
2018
3
Choriocarcinoma with multiple lung metastases from complete hydatidiform mole with coexistent fetus during pregnancy. ( 29845692 )
2018
4
Serum angiogenesis profile in gestational trophoblastic neoplasm using multiplex immunoassay. ( 30195618 )
2018
5
Multiple metastatic gestational trophoblastic disease after a twin pregnancy with complete hydatidiform mole and coexisting fetus, following assisted reproductive technology: Case report and literature review. ( 30122584 )
2018
6
Hydatidiform mole: validity of the registration in the Danish National Patient Registry, the Danish Cancer Registry, and the Danish Pathology Registry 1999-2009. ( 30271218 )
2018
7
Ultrasound and MRI Findings of Twin Pregnancies with Complete Hydatidiform Mole and Coexisting Normal Fetus: Two Case Reports. ( 30282891 )
2018
8
Correction to: ''Bunch of grapes'' in complete hydatidiform mole. ( 30284604 )
2018
9
DNA Genotyping of Nonmolar Donor Egg Pregnancies With Abnormal Villous Morphology: Allele Zygosity Patterns Prevent Misinterpretation as Complete Hydatidiform Mole. ( 28463912 )
2018
10
New insights in the pathophysiology of complete hydatidiform mole. ( 29405964 )
2018
11
A fetus coexisting with a complete hydatidiform mole with trisomy 9 of maternal origin. ( 29436108 )
2018
12
Temporal trends in incidence and outcome of hydatidiform mole: a retrospective cohort study. ( 29451409 )
2018
13
Does a human chorionic gonadotropin level of over 20,000 IU/L four weeks after uterine evacuation for complete hydatidiform mole constitute an indication for chemotherapy for gestational trophoblastic neoplasia? ( 29477553 )
2018
14
A 34-Week Size Uterus with a Complete Hydatidiform Mole: Hook Effect and Severe Anemia with No Vaginal Bleeding. ( 29670785 )
2018
15
Recurrent complete hydatidiform mole: where we are, is there a safe gestational horizon? Opinion and mini-review. ( 29737470 )
2018
16
Accuracy of p57KIP2 compared with genotyping to diagnose complete hydatidiform mole: a systematic review and meta-analysis. ( 29782064 )
2018
17
Prevalence and Factors Associated with Hydatidiform Mole among Patients Undergoing Uterine Evacuation at Mbarara Regional Referral Hospital. ( 29805452 )
2018
18
Invasive hydatidiform mole in the cervix. ( 29875909 )
2018
19
p57KIP2 immunostaining for diagnosis of hydatidiform mole. ( 29904999 )
2018
20
miR-21 Is Overexpressed in Hydatidiform Mole Tissues and Promotes Proliferation, Migration, and Invasion in Choriocarcinoma Cells. ( 27922982 )
2017
21
A pilot randomized controlled clinical trial of second uterine curettage versus usual care to determine the effect of re-curettage on patients' need for chemotherapy among women with low risk, nonmetastatic gestational trophoblastic neoplasm in Urmia, Iran. ( 29033610 )
2017
22
Prenatal Diagnosis of Twin Pregnancies with Complete Hydatidiform Mole and Coexistent Normal Fetus: A Series of 13 Cases. ( 27522447 )
2017
23
"Bunch of grapes" in complete hydatidiform mole. ( 27933479 )
2017
24
Role of Surgery in the Management of Hydatidiform Mole in Elderly Patients: A Single-Center Clinical Experience. ( 28129241 )
2017
25
HDLive Silhouette Inversion Mode in Diagnosis of Complete Hydatidiform Mole. ( 28133778 )
2017
26
Complete hydatidiform mole with co-existing fetus: Predictors of live birth. ( 28301807 )
2017
27
F10, a novel hydatidiform mole-associated gene, inhibits the paclitaxel sensitivity of A549 lung cancer cells by downregulating BAX and caspase-3. ( 28454434 )
2017
28
Uterine artery Doppler flow velocimetry parameters for predicting gestational trophoblastic neoplasia after complete hydatidiform mole, a prospective cohort study. ( 28591340 )
2017
29
Establishment and characterization of cell lines derived from complete hydatidiform mole. ( 28713902 )
2017
30
Molecular Diagnosis of Placental Hydatidiform Mole: Innovation and Outcomes. ( 28757408 )
2017
31
18F-FDG PET/CT Demonstrating Chorioadenoma Destruens After Evacuation of Complete Hydatidiform Mole. ( 28759528 )
2017
32
Heterotopic Pregnancy Including Intrauterine Normal Gestation and Tubal Complete Hydatidiform Mole: A Case Report and Review of the Literature. ( 28800576 )
2017
33
Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia. ( 28892119 )
2017
34
An unexpected invasive hydatidiform mole in a rudimentary uterine horn: A case report. ( 28927039 )
2017
35
Challenges in the Routine Praxis Diagnosis of Hydatidiform Mole: a Tertiary Health Center Experience. ( 28974845 )
2017
36
Risk Factors for Hydatidiform Mole: Is Husband’s Job a Major Risk Factor? ( 29072060 )
2017
37
Whole-exome sequencing reveals genetic variants in ERC1 and KCNG4 associated with complete hydatidiform mole in Chinese Han women. ( 29088863 )
2017
38
Comparison of different therapeutic strategies for complete hydatidiform mole in women at least 40 years old: a retrospective cohort study. ( 29121880 )
2017
39
A twin pregnancy with a hydatidiform mole and a coexisting live fetus: prenatal diagnosis, treatment, and follow-up. ( 29375907 )
2017
40
May supplementation of coenzyme Q10 help prevent development of hydatidiform mole?. ( 29949281 )
2017
41
Unusual twin pregnancy: complete hydatidiform mole with coexistent normal fetus. ( 29949305 )
2017
42
Trends in ectopic pregnancy, hydatidiform mole and miscarriage in the largest obstetrics and gynaecology hospital in China from 2003 to 2013. ( 27206481 )
2016
43
Partial hydatidiform mole in a phenylketonuria patient treated with sapropterin dihydrochloride. ( 27898272 )
2016
44
Diginyc partial hydatidiform mole with increased fetal nuchal translucency and ovarian hyperstimulation syndrome. ( 27328519 )
2016
45
Two novel mutations in the KHDC3L gene in Asian patients with recurrent hydatidiform mole. ( 27621838 )
2016
46
Unusual Presentation of Hypothyroidism in a Pregnant Woman, Mimicking Gestational Trophoblastic Neoplasm. ( 27034864 )
2016
47
Histological comparison of partial hydatidiform mole and trisomy gestation specimens. ( 27575970 )
2016
48
A Reappraisal of the Incidence of Placental Hydatidiform Mole Using Selective Molecular Genotyping. ( 27258730 )
2016
49
Solitary lung metastasis from gestational choriocarcinoma resected six years after hydatidiform mole: A case report. ( 27744215 )
2016
50
Clinical Presentation of Complete Hydatidiform Mole and Partial Hydatidiform Mole at a Regional Trophoblastic Disease Center in the United States Over the Past 2 Decades. ( 26588240 )
2016
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Variations for Gestational Trophoblastic Neoplasm

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Expression for Gestational Trophoblastic Neoplasm

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Search GEO for disease gene expression data for Gestational Trophoblastic Neoplasm.
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Pathways for Gestational Trophoblastic Neoplasm

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Pathways related to Gestational Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Nucleotide-binding Oligomerization Domain (NOD) pathway 1
10.24 NLRP2 NLRP7
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GO Terms for Gestational Trophoblastic Neoplasm

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Biological processes related to Gestational Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-1 beta secretion GO:0050718 9.37 NLRP2 NLRP7
2 positive regulation of JAK-STAT cascade GO:0046427 9.32 CSH1 CSH2
3 adrenal gland development GO:0030325 9.26 CDKN1C NR0B1
4 animal organ development GO:0048513 9.16 CSH1 CSH2
5 growth hormone receptor signaling pathway GO:0060396 8.96 CSH1 CSH2
6 positive regulation of growth GO:0045927 8.62 CSH1 CSH2

Molecular functions related to Gestational Trophoblastic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 CSH1 CSH2 OXT
2 growth hormone receptor binding GO:0005131 8.62 CSH1 CSH2
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Sources for Gestational Trophoblastic Neoplasm

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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