MCID: GNT019
MIFTS: 33

Giant Cell Myocarditis

Categories: Rare diseases

Aliases & Classifications for Giant Cell Myocarditis

MalaCards integrated aliases for Giant Cell Myocarditis:

Name: Giant Cell Myocarditis 53 73
Idiopathic Giant-Cell Myocarditis 53
Idiopathic Giant Cell Myocarditis 59
Igcm 59
Gcm 53

Characteristics:

Orphanet epidemiological data:

59
idiopathic giant cell myocarditis
Age of onset: Adolescent,Adult;

Classifications:



External Ids:

Orphanet 59 ORPHA329874
ICD10 via Orphanet 34 I40.8
UMLS 73 C0264856

Summaries for Giant Cell Myocarditis

MalaCards based summary : Giant Cell Myocarditis, also known as idiopathic giant-cell myocarditis, is related to myocarditis and fontaine progeroid syndrome. An important gene associated with Giant Cell Myocarditis is DES (Desmin), and among its related pathways/superpathways is Epstein-Barr virus infection. The drugs Miconazole and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include heart, monocytes and t cells.

Wikipedia : 76 Idiopathic giant-cell myocarditis (IGCM) is a cardiovascular disease of the muscle of the heart... more...

Related Diseases for Giant Cell Myocarditis

Diseases related to Giant Cell Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 myocarditis 30.7 HLA-B MB
2 fontaine progeroid syndrome 11.9
3 breast rhabdomyosarcoma 10.3 DES MB
4 malignant triton tumor 10.2 DES MB
5 botryoid rhabdomyosarcoma 10.2 DES MB
6 mesenchymoma 10.2 DES MB
7 spindle cell rhabdomyosarcoma 10.2 DES MB
8 myofibroma 10.2 DES MB
9 inflammatory leiomyosarcoma 10.2 CD68 DES
10 bilateral retinoblastoma 10.2 DES MB
11 myositis 10.2
12 ischemic fasciitis 10.2 CD68 DES
13 adenosarcoma 10.2 DES MB
14 virus associated hemophagocytic syndrome 10.2 CD68 MB
15 thymoma 10.2
16 granular cell tumor 10.2 CD68 DES
17 sarcomatoid squamous cell skin carcinoma 10.2 CD68 MB
18 congenital epulis 10.1 CD68 DES
19 infantile myofibromatosis 10.1 DES MB
20 mixed liposarcoma 10.1 CD68 MB
21 medullomyoblastoma 10.1 DES MB
22 malignant mesenchymoma 10.1 DES MB
23 uterine sarcoma 10.1 DES MB
24 myxosarcoma 10.1 CD68 MB
25 glomangioma 10.1 DES MB
26 muscle cancer 10.0 DES MB
27 embryonal rhabdomyosarcoma 10.0 DES MB
28 myasthenia gravis 10.0
29 cardiac sarcoidosis 10.0
30 myasthenia gravis congenital 10.0
31 alveolar soft part sarcoma 10.0 DES MB
32 rhabdomyosarcoma 2 10.0 DES MB
33 thrombocytopenia 9.9
34 atrioventricular block 9.9
35 heparin-induced thrombocytopenia 9.9
36 polymyositis 9.9
37 cardiogenic shock 9.9
38 indeterminate leprosy 9.9 CD68 HLA-B
39 leiomyosarcoma 9.9 DES MB
40 liposarcoma 9.9 DES MB
41 mevalonic aciduria 9.9
42 hypogonadotropic hypogonadism 9.9
43 hypoparathyroidism 9.9
44 hypogonadism 9.9
45 myoblastoma 9.9
46 autoimmune disease 9.8
47 autoimmune disease 1 9.8
48 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
49 dilated cardiomyopathy 9.8
50 ulcerative colitis 9.8

Graphical network of the top 20 diseases related to Giant Cell Myocarditis:



Diseases related to Giant Cell Myocarditis

Symptoms & Phenotypes for Giant Cell Myocarditis

Drugs & Therapeutics for Giant Cell Myocarditis

Drugs for Giant Cell Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2,Not Applicable 22916-47-8 4189
2
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
4
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
5 Prednisolone acetate Phase 2
6 Muromonab-CD3 Phase 2,Not Applicable
7 glucocorticoids Phase 2
8 Methylprednisolone acetate Phase 2
9 Methylprednisolone Hemisuccinate Phase 2
10 Gastrointestinal Agents Phase 2
11 Neuroprotective Agents Phase 2
12 Cyclosporins Phase 2,Not Applicable
13 Hormone Antagonists Phase 2
14 Dermatologic Agents Phase 2,Not Applicable
15 Hormones Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
17 Peripheral Nervous System Agents Phase 2
18 Immunosuppressive Agents Phase 2,Not Applicable
19 Prednisolone hemisuccinate Phase 2
20 Prednisolone phosphate Phase 2
21 Anti-Infective Agents Phase 2,Not Applicable
22 Antiemetics Phase 2
23 Antifungal Agents Phase 2,Not Applicable
24 Protective Agents Phase 2
25 Anti-Inflammatory Agents Phase 2
26 Antirheumatic Agents Phase 2,Not Applicable
27 Autonomic Agents Phase 2
28 Calcineurin Inhibitors Phase 2,Not Applicable
29 Antineoplastic Agents, Hormonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Randomized Study of Muromonab-CD3, Cyclosporine, Methylprednisolone, and Prednisone in Patients With Giant Cell Myocarditis Completed NCT00004482 Phase 2 Cyclosporine;methylprednisolone;Muromonab-CD3;prednisone
2 Study of Muromonab-CD3 and Cyclosporine in Patients With Giant Cell Myocarditis Completed NCT00027443 Not Applicable Muromonab-CD3;Cyclosporine
3 Sahlgrenska Cardiomyopathy Project Not yet recruiting NCT03527342

Search NIH Clinical Center for Giant Cell Myocarditis

Genetic Tests for Giant Cell Myocarditis

Anatomical Context for Giant Cell Myocarditis

MalaCards organs/tissues related to Giant Cell Myocarditis:

41
Heart, Monocytes, T Cells, Skin, Lung, Bone, Bone Marrow

Publications for Giant Cell Myocarditis

Articles related to Giant Cell Myocarditis:

(show top 50) (show all 231)
# Title Authors Year
1
Hemoadsorption in cardiac shock with biventricular failure and giant-cell myocarditis: A case report. ( 29843541 )
2018
2
Fulminant giant-cell myocarditis on mechanical circulatory support: Management and outcomes of a French multicentre cohort. ( 29306448 )
2018
3
Sirolimus for Recurrent Giant Cell Myocarditis After Heart Transplantation: A Unique Therapeutic Strategy. ( 29889677 )
2018
4
Giant cell myocarditis causing refractory ventricular tachycardia in a pediatric patient. ( 29636926 )
2018
5
Images of atrial giant cell myocarditis. ( 29186397 )
2018
6
Still poor prognosis for patients with giant cell myocarditis in the era of temporary mechanical circulatory supports. ( 29306450 )
2018
7
Conduction Dysfunction and Near Expunction: Giant Cell Myocarditis. ( 29729236 )
2018
8
Giant cell myocarditis presenting with acute heart failure. ( 28536222 )
2017
9
Giant cell myocarditis masquerading as orbital myositis with a rapid, fulminant course necessitating mechanical support and heart transplantation. ( 28772042 )
2017
10
A fulminant case of idiopathic giant cell myocarditis. ( 28745125 )
2017
11
A Complex Heart Team's Approach to a Patient With Giant Cell Myocarditis. ( 28822649 )
2017
12
Comparative immunologic characterization of autoimmune giant cell myocarditis with ipilimumab. ( 29209563 )
2017
13
Heart Transplantation in Giant Cell Myocarditis: Analysis of the United Network for Organ Sharing Registry. ( 28449952 )
2017
14
Immunosuppressive treatment in fulminant myocarditis and gene expression pattern associated with, but no histological confirmation of giant cell myocarditis. ( 28451456 )
2017
15
Treatment of Fulminant Giant Cell Myocarditis Associated with Polymyositis Using a Left Ventricular Assist Device and Subsequent Corticosteroid and Immunosuppressive Therapy Leading to Remission. ( 28781324 )
2017
16
Ablation of an electrical storm in a patient with giant cell myocarditis using continuous flow left ventricular assist device and percutaneous right ventricular assist device. ( 26882191 )
2016
17
Long-term outcome and its predictors in giant cell myocarditis. ( 27407025 )
2016
18
Lack of Relationship Between Serum Cardiac Troponin I Level and Giant Cell Myocarditis Diagnosis and Outcomes. ( 26768222 )
2016
19
Incidence, Risk Factors, and Outcome of Life-Threatening Ventricular Arrhythmias in Giant Cell Myocarditis. ( 27913400 )
2016
20
Giant cell myocarditis associated with multiple autoimmune disorders following highly active antiretroviral therapy for human immunodeficiency virus type 1 infection. ( 26780680 )
2016
21
Giant Cell Myocarditis: A Brief Review. ( 27922771 )
2016
22
Giant cell myocarditis: a life-threatening disorder heralded by orbital myositis. ( 27009192 )
2016
23
Hemodynamic Transesophageal Echocardiography-Guided Venous-Arterial Extracorporeal Membrane Oxygenation Support in a Case of Giant Cell Myocarditis. ( 27648312 )
2016
24
Poster 224 Giant Cell Myocarditis Masked by Acute Inflammatory Demyelinating Polyneuropathy: A Case Report. ( 27672982 )
2016
25
Giant cell myocarditis: still a conundrum. The need for a worldwide registry. ( 27647798 )
2016
26
Idiopathic giant cell myocarditis in a newborn: case report. ( 28276219 )
2016
27
Acute cytomegalovirus infection triggering fatal giant cell myocarditis. ( 27070993 )
2016
28
Spontaneous Remission in a Case of Giant Cell Myocarditis with Preserved Left Ventricular Ejection Fraction. ( 26581394 )
2015
29
Small Steps for Idiopathic Giant Cell Myocarditis. ( 25895034 )
2015
30
Modern day management of giant cell myocarditis. ( 25464225 )
2015
31
Usefulness of Rabbit Anti-thymocyte Globulin in Patients With Giant Cell Myocarditis. ( 26048854 )
2015
32
Rapidly Progressive Cardiac Failure Due to Giant Cell Myocarditis: A Clinical Pathology Conference Held by the Division of Rheumatology at Hospital for Special Surgery. ( 26140040 )
2015
33
Giant Cell Myocarditis: Not Always a Presentation of Cardiogenic Shock. ( 26257963 )
2015
34
Alemtuzumab as a novel treatment for refractory giant cell myocarditis after heart transplantation. ( 26508724 )
2015
35
Giant cell myocarditis in hypersensitivity reactions: is an early diagnose possible? ( 26165744 )
2015
36
Giant cell myocarditis successfully treated with antithymocyte globuline and extracorporeal membrane oxygenation for 21 days. ( 25643196 )
2015
37
Fulminant heart failure due to giant cell myocarditis affecting the left ventricle. ( 26677392 )
2015
38
Idiopathic giant cell myocarditis in childhood: A case report. ( 26275338 )
2015
39
Long term biventricular support with Berlin Heart Excor in a Septuagenarian with giant-cell myocarditis. ( 25637129 )
2015
40
Long-Term Risk of Recurrence, Morbidity and Mortality in Giant Cell Myocarditis. ( 25882774 )
2015
41
A passionate endurance cyclist ultimately survives sudden death in right ventricular giant cell myocarditis. ( 24290425 )
2014
42
When Should We Consider the Diagnosis of Giant Cell Myocarditis? Revisiting "Classic" Echocardiographic and Clinical Features of This Rare Pathology. ( 24650294 )
2014
43
Epsilon waves in giant-cell myocarditis. ( 23990602 )
2014
44
Recovery of giant-cell myocarditis using combined cytolytic immunosuppression and mechanical circulatory support. ( 24656644 )
2014
45
Fatal recurrence of fulminant giant cell myocarditis and recovery after initialisation of an alternative immunosuppressive regime. ( 25246472 )
2014
46
BehAset's disease complicated by giant-cell myocarditis. ( 25088896 )
2014
47
Cardiac magnetic resonance imaging in giant cell myocarditis: intriguing associations with clinical and pathological features. ( 24778123 )
2014
48
The Changing Role for Endomyocardial Biopsy in the Diagnosis of Giant-Cell Myocarditis. ( 25135591 )
2014
49
Rituximab in recurrent idiopathic giant cell myocarditis after heart transplantation: a potential therapeutic approach. ( 24444397 )
2014
50
Improved diagnosis of idiopathic giant cell myocarditis and cardiac sarcoidosis by myocardial gene expression profiling. ( 24667923 )
2014

Variations for Giant Cell Myocarditis

Expression for Giant Cell Myocarditis

Search GEO for disease gene expression data for Giant Cell Myocarditis.

Pathways for Giant Cell Myocarditis

Pathways related to Giant Cell Myocarditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.93 HLA-B IL10RA

GO Terms for Giant Cell Myocarditis

Sources for Giant Cell Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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