GCM
MCID: GNT019
MIFTS: 33

Giant Cell Myocarditis (GCM)

Categories: Rare diseases

Aliases & Classifications for Giant Cell Myocarditis

MalaCards integrated aliases for Giant Cell Myocarditis:

Name: Giant Cell Myocarditis 53 73
Idiopathic Giant-Cell Myocarditis 53
Idiopathic Giant Cell Myocarditis 59
Igcm 59
Gcm 53

Characteristics:

Orphanet epidemiological data:

59
idiopathic giant cell myocarditis
Age of onset: Adolescent,Adult;

Classifications:



External Ids:

Orphanet 59 ORPHA329874
ICD10 via Orphanet 34 I40.8
UMLS 73 C0264856

Summaries for Giant Cell Myocarditis

MalaCards based summary : Giant Cell Myocarditis, also known as idiopathic giant-cell myocarditis, is related to myocarditis and fontaine progeroid syndrome. An important gene associated with Giant Cell Myocarditis is HLA-B (Major Histocompatibility Complex, Class I, B). The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and lung.

Wikipedia : 76 Idiopathic giant-cell myocarditis (IGCM) is a cardiovascular disease of the muscle of the heart... more...

Related Diseases for Giant Cell Myocarditis

Diseases related to Giant Cell Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 myocarditis 31.5 HLA-B MB
2 fontaine progeroid syndrome 12.1
3 myositis 10.3
4 thymoma 10.3
5 cardiac sarcoidosis 10.2
6 myasthenia gravis 10.1
7 myasthenia gravis congenital 10.1
8 thrombocytopenia 10.1
9 atrioventricular block 10.1
10 heparin-induced thrombocytopenia 10.1
11 polymyositis 10.1
12 cardiogenic shock 10.1
13 inflammatory leiomyosarcoma 10.0 CD68 DES
14 ischemic fasciitis 10.0 CD68 DES
15 indeterminate leprosy 10.0 CD68 HLA-B
16 granular cell tumor 10.0 CD68 DES
17 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 10.0
18 mevalonic aciduria 10.0
19 myoclonic-atonic epilepsy 10.0
20 hypogonadotropic hypogonadism 10.0
21 hypoparathyroidism 10.0
22 hypogonadism 10.0
23 myoblastoma 10.0
24 congenital epulis 10.0 CD68 DES
25 cytomegalovirus retinitis 10.0 HLA-B IL10RA
26 autoimmune disease 10.0
27 sarcoidosis 1 10.0
28 dilated cardiomyopathy 10.0
29 ulcerative colitis 10.0
30 lymphoma 10.0
31 colitis 10.0
32 virus associated hemophagocytic syndrome 9.9 CD68 MB
33 malignant triton tumor 9.9 DES MB
34 botryoid rhabdomyosarcoma 9.9 DES MB
35 rhabdomyosarcoma 9.9 DES MB
36 mesenchymoma 9.9 DES MB
37 spindle cell rhabdomyosarcoma 9.9 DES MB
38 myofibroma 9.9 DES MB
39 leiomyosarcoma 9.9 DES MB
40 bilateral retinoblastoma 9.9 DES MB
41 mixed liposarcoma 9.9 CD68 MB
42 liposarcoma 9.9 DES MB
43 adenosarcoma 9.9 DES MB
44 dedifferentiated liposarcoma 9.9 DES MB
45 myxosarcoma 9.9 CD68 MB
46 sarcomatoid squamous cell skin carcinoma 9.9 CD68 MB
47 infantile myofibromatosis 9.9 DES MB
48 medullomyoblastoma 9.9 DES MB
49 malignant mesenchymoma 9.9 DES MB
50 uterine sarcoma 9.9 DES MB

Graphical network of the top 20 diseases related to Giant Cell Myocarditis:



Diseases related to Giant Cell Myocarditis

Symptoms & Phenotypes for Giant Cell Myocarditis

Drugs & Therapeutics for Giant Cell Myocarditis

Drugs for Giant Cell Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
4
Miconazole Approved, Investigational, Vet_approved Phase 2,Not Applicable 22916-47-8 4189
5
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
6
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
7
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
8 Neuroprotective Agents Phase 2
9 Hormones Phase 2
10 Antirheumatic Agents Phase 2,Not Applicable
11 Protective Agents Phase 2
12 Autonomic Agents Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
14 Calcineurin Inhibitors Phase 2,Not Applicable
15 Cyclosporins Phase 2,Not Applicable
16 Antiemetics Phase 2
17 Gastrointestinal Agents Phase 2
18 Immunologic Factors Phase 2,Not Applicable
19 Immunosuppressive Agents Phase 2,Not Applicable
20 glucocorticoids Phase 2
21 Peripheral Nervous System Agents Phase 2
22 Anti-Inflammatory Agents Phase 2
23 Muromonab-CD3 Phase 2,Not Applicable
24 Antifungal Agents Phase 2,Not Applicable
25 Methylprednisolone acetate Phase 2
26 Antineoplastic Agents, Hormonal Phase 2
27 Prednisolone acetate Phase 2
28 Dermatologic Agents Phase 2,Not Applicable
29 Hormone Antagonists Phase 2
30 Anti-Infective Agents Phase 2,Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Randomized Study of Muromonab-CD3, Cyclosporine, Methylprednisolone, and Prednisone in Patients With Giant Cell Myocarditis Completed NCT00004482 Phase 2 Cyclosporine;methylprednisolone;Muromonab-CD3;prednisone
2 Study of Muromonab-CD3 and Cyclosporine in Patients With Giant Cell Myocarditis Completed NCT00027443 Not Applicable Muromonab-CD3;Cyclosporine
3 Sahlgrenska Cardiomyopathy Project Enrolling by invitation NCT03527342

Search NIH Clinical Center for Giant Cell Myocarditis

Genetic Tests for Giant Cell Myocarditis

Anatomical Context for Giant Cell Myocarditis

MalaCards organs/tissues related to Giant Cell Myocarditis:

41
Heart, Bone, Lung, Skin, Thyroid, T Cells, Bone Marrow

Publications for Giant Cell Myocarditis

Articles related to Giant Cell Myocarditis:

(show top 50) (show all 241)
# Title Authors Year
1
Hemoadsorption in cardiac shock with biventricular failure and giant-cell myocarditis: A case report. ( 29843541 )
2018
2
Fulminant giant-cell myocarditis on mechanical circulatory support: Management and outcomes of a French multicentre cohort. ( 29306448 )
2018
3
Sirolimus for Recurrent Giant Cell Myocarditis After Heart Transplantation: A Unique Therapeutic Strategy. ( 29889677 )
2018
4
Giant cell myocarditis causing refractory ventricular tachycardia in a pediatric patient. ( 29636926 )
2018
5
Images of atrial giant cell myocarditis. ( 29186397 )
2018
6
Still poor prognosis for patients with giant cell myocarditis in the era of temporary mechanical circulatory supports. ( 29306450 )
2018
7
Conduction Dysfunction and Near Expunction: Giant Cell Myocarditis. ( 29729236 )
2018
8
Importance of endomyocardial biopsy in distinguishing between cardiac sarcoidosis and giant cell myocarditis : Need to distinguish between sarcoidosis and giant cell myocarditis. ( 30470883 )
2018
9
Left Atrial Giant Cell Myocarditis Presenting as a Tumor: First-in-Man Case Report. ( 30043925 )
2018
10
Giant cell myocarditis presenting with acute heart failure. ( 28536222 )
2017
11
Giant cell myocarditis masquerading as orbital myositis with a rapid, fulminant course necessitating mechanical support and heart transplantation. ( 28772042 )
2017
12
A fulminant case of idiopathic giant cell myocarditis. ( 28745125 )
2017
13
A Complex Heart Team's Approach to a Patient With Giant Cell Myocarditis. ( 28822649 )
2017
14
Comparative immunologic characterization of autoimmune giant cell myocarditis with ipilimumab. ( 29209563 )
2017
15
Heart Transplantation in Giant Cell Myocarditis: Analysis of the United Network for Organ Sharing Registry. ( 28449952 )
2017
16
Immunosuppressive treatment in fulminant myocarditis and gene expression pattern associated with, but no histological confirmation of giant cell myocarditis. ( 28451456 )
2017
17
Treatment of Fulminant Giant Cell Myocarditis Associated with Polymyositis Using a Left Ventricular Assist Device and Subsequent Corticosteroid and Immunosuppressive Therapy Leading to Remission. ( 28781324 )
2017
18
Ablation of an electrical storm in a patient with giant cell myocarditis using continuous flow left ventricular assist device and percutaneous right ventricular assist device. ( 26882191 )
2016
19
Long-term outcome and its predictors in giant cell myocarditis. ( 27407025 )
2016
20
Lack of Relationship Between Serum Cardiac Troponin I Level and Giant Cell Myocarditis Diagnosis and Outcomes. ( 26768222 )
2016
21
Incidence, Risk Factors, and Outcome of Life-Threatening Ventricular Arrhythmias in Giant Cell Myocarditis. ( 27913400 )
2016
22
Giant cell myocarditis associated with multiple autoimmune disorders following highly active antiretroviral therapy for human immunodeficiency virus type 1 infection. ( 26780680 )
2016
23
Giant Cell Myocarditis: A Brief Review. ( 27922771 )
2016
24
Giant cell myocarditis: a life-threatening disorder heralded by orbital myositis. ( 27009192 )
2016
25
Hemodynamic Transesophageal Echocardiography-Guided Venous-Arterial Extracorporeal Membrane Oxygenation Support in a Case of Giant Cell Myocarditis. ( 27648312 )
2016
26
Poster 224 Giant Cell Myocarditis Masked by Acute Inflammatory Demyelinating Polyneuropathy: A Case Report. ( 27672982 )
2016
27
Giant cell myocarditis: still a conundrum. The need for a worldwide registry. ( 27647798 )
2016
28
Idiopathic giant cell myocarditis in a newborn: case report. ( 28276219 )
2016
29
Acute cytomegalovirus infection triggering fatal giant cell myocarditis. ( 27070993 )
2016
30
A case of a giant cell myocarditis that developed massive left ventricular thrombus during percutaneous cardiopulmonary support. ( 29492436 )
2016
31
Spontaneous Remission in a Case of Giant Cell Myocarditis with Preserved Left Ventricular Ejection Fraction. ( 26581394 )
2015
32
Small Steps for Idiopathic Giant Cell Myocarditis. ( 25895034 )
2015
33
Modern day management of giant cell myocarditis. ( 25464225 )
2015
34
Usefulness of Rabbit Anti-thymocyte Globulin in Patients With Giant Cell Myocarditis. ( 26048854 )
2015
35
Rapidly Progressive Cardiac Failure Due to Giant Cell Myocarditis: A Clinical Pathology Conference Held by the Division of Rheumatology at Hospital for Special Surgery. ( 26140040 )
2015
36
Giant Cell Myocarditis: Not Always a Presentation of Cardiogenic Shock. ( 26257963 )
2015
37
Alemtuzumab as a novel treatment for refractory giant cell myocarditis after heart transplantation. ( 26508724 )
2015
38
Giant cell myocarditis in hypersensitivity reactions: is an early diagnose possible? ( 26165744 )
2015
39
Giant cell myocarditis successfully treated with antithymocyte globuline and extracorporeal membrane oxygenation for 21 days. ( 25643196 )
2015
40
Fulminant heart failure due to giant cell myocarditis affecting the left ventricle. ( 26677392 )
2015
41
Idiopathic giant cell myocarditis in childhood: A case report. ( 26275338 )
2015
42
Long term biventricular support with Berlin Heart Excor in a Septuagenarian with giant-cell myocarditis. ( 25637129 )
2015
43
Long-Term Risk of Recurrence, Morbidity and Mortality in Giant Cell Myocarditis. ( 25882774 )
2015
44
Sudden Death Due to Giant Cell Myocarditis: A Case Report. ( 28197261 )
2015
45
A passionate endurance cyclist ultimately survives sudden death in right ventricular giant cell myocarditis. ( 24290425 )
2014
46
When Should We Consider the Diagnosis of Giant Cell Myocarditis? Revisiting "Classic" Echocardiographic and Clinical Features of This Rare Pathology. ( 24650294 )
2014
47
Epsilon waves in giant-cell myocarditis. ( 23990602 )
2014
48
Recovery of giant-cell myocarditis using combined cytolytic immunosuppression and mechanical circulatory support. ( 24656644 )
2014
49
Fatal recurrence of fulminant giant cell myocarditis and recovery after initialisation of an alternative immunosuppressive regime. ( 25246472 )
2014
50
BehAset's disease complicated by giant-cell myocarditis. ( 25088896 )
2014

Variations for Giant Cell Myocarditis

Expression for Giant Cell Myocarditis

Search GEO for disease gene expression data for Giant Cell Myocarditis.

Pathways for Giant Cell Myocarditis

GO Terms for Giant Cell Myocarditis

Sources for Giant Cell Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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