GCM
MCID: GNT019
MIFTS: 29

Giant Cell Myocarditis (GCM)

Categories: Rare diseases

Aliases & Classifications for Giant Cell Myocarditis

MalaCards integrated aliases for Giant Cell Myocarditis:

Name: Giant Cell Myocarditis 20 70
Idiopathic Giant-Cell Myocarditis 20
Idiopathic Giant Cell Myocarditis 58
Igcm 58
Gcm 20

Characteristics:

Orphanet epidemiological data:

58
idiopathic giant cell myocarditis
Age of onset: Adolescent,Adult;

Classifications:



External Ids:

ICD10 via Orphanet 33 I40.8
Orphanet 58 ORPHA329874
UMLS 70 C0264856

Summaries for Giant Cell Myocarditis

MalaCards based summary : Giant Cell Myocarditis, also known as idiopathic giant-cell myocarditis, is related to myocarditis and myositis. An important gene associated with Giant Cell Myocarditis is CD68 (CD68 Molecule). The drugs Prednisolone acetate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and bone marrow.

Wikipedia : 73 Idiopathic giant-cell myocarditis (IGCM) is a cardiovascular disease of the muscle of the heart... more...

Related Diseases for Giant Cell Myocarditis

Diseases related to Giant Cell Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 myocarditis 31.4 MB HLA-B CD68
2 myositis 30.4 MB HLA-B
3 leprosy 3 29.7 HLA-B CD68
4 fontaine progeroid syndrome 11.6
5 sarcoidosis 1 10.6
6 cardiogenic shock 10.6
7 cardiac sarcoidosis 10.6
8 thymoma, familial 10.5
9 thymoma 10.5
10 myasthenia gravis 10.4
11 autoimmune myocarditis 10.4
12 atrioventricular block 10.4
13 acute myocarditis 10.4
14 autoimmune disease 10.4
15 dilated cardiomyopathy 10.3
16 polymyositis 10.3
17 hemopericardium 10.3
18 orbital plasma cell granuloma 10.3
19 cardiac conduction defect 10.2
20 allergic disease 10.2
21 thrombocytopenia 10.2
22 mitral valve stenosis 10.2
23 thymic carcinoma 10.2
24 ulcerative colitis 10.2
25 vitiligo-associated multiple autoimmune disease susceptibility 6 10.2
26 vitiligo-associated multiple autoimmune disease susceptibility 1 10.2
27 ptosis 10.2
28 pericardial effusion 10.2
29 congestive heart failure 10.2
30 thyroiditis 10.2
31 heparin-induced thrombocytopenia 10.2
32 syncope 10.2
33 fibrous histiocytoma 10.1 DES CD68
34 progressive familial heart block, type ia 10.1
35 kaposi sarcoma 10.1
36 atrioventricular dissociation 10.1
37 immune deficiency disease 10.1
38 sjogren syndrome 10.1
39 ventricular fibrillation, paroxysmal familial, 1 10.1
40 progressive familial heart block, type ib 10.1
41 arrhythmogenic right ventricular cardiomyopathy 10.1
42 exanthem 10.1
43 colitis 10.1
44 cardiac arrest 10.1
45 fiedler's myocarditis 10.1
46 sarcoma 10.1
47 right bundle branch block 10.1
48 hypothyroidism 10.1
49 pericarditis 10.1
50 agammaglobulinemia 10.1

Graphical network of the top 20 diseases related to Giant Cell Myocarditis:



Diseases related to Giant Cell Myocarditis

Symptoms & Phenotypes for Giant Cell Myocarditis

Drugs & Therapeutics for Giant Cell Myocarditis

Drugs for Giant Cell Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
2
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
4
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
5
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
6
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
7
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
8
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
9
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
10 Neuroprotective Agents Phase 2
11 Gastrointestinal Agents Phase 2
12 Methylprednisolone Acetate Phase 2
13 glucocorticoids Phase 2
14 Muromonab-CD3 Phase 2
15 Antirheumatic Agents Phase 2
16 Immunosuppressive Agents Phase 2
17 Hormones Phase 2
18 Anti-Infective Agents Phase 2
19 Cyclosporins Phase 2
20 Hormone Antagonists Phase 2
21 Calcineurin Inhibitors Phase 2
22 Antineoplastic Agents, Hormonal Phase 2
23 Immunologic Factors Phase 2
24 Anti-Inflammatory Agents Phase 2
25 Dermatologic Agents Phase 2
26 Antiemetics Phase 2
27 Antifungal Agents Phase 2
28 Protective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Randomized Study of Muromonab-CD3, Cyclosporine, Methylprednisolone, and Prednisone in Patients With Giant Cell Myocarditis Completed NCT00004482 Phase 2 Cyclosporine;methylprednisolone;Muromonab-CD3;prednisone
2 Giant Cell Myocarditis Treatment Trial Pilot Study Completed NCT00027443 Muromonab-CD3;Cyclosporine

Search NIH Clinical Center for Giant Cell Myocarditis

Genetic Tests for Giant Cell Myocarditis

Anatomical Context for Giant Cell Myocarditis

MalaCards organs/tissues related to Giant Cell Myocarditis:

40
Heart, T Cells, Bone Marrow, Skeletal Muscle

Publications for Giant Cell Myocarditis

Articles related to Giant Cell Myocarditis:

(show top 50) (show all 441)
# Title Authors PMID Year
1
Cardiac Sarcoidosis and Giant Cell Myocarditis: Actually, 2 Ends of the Same Disease? 61
33660527 2021
2
Manifestations and Outcome of Cardiac Sarcoidosis and Idiopathic Giant Cell Myocarditis by 25-Year Nationwide Cohorts. 61
33660520 2021
3
Fulminant cardiac sarcoidosis resembling giant cell myocarditis: a case report. 61
33733047 2021
4
Late gadolinium enhancement characteristics in giant cell myocarditis. 61
33655686 2021
5
Management of Patients With Giant Cell Myocarditis: JACC Review Topic of the Week. 61
33632487 2021
6
Eosinophilic Myocarditis Progresses to Giant Cell Myocarditis Requiring Heart Transplantation: A Case Report. 61
33474869 2021
7
Prophylactic use of vacuum-assisted closure system for cannula sites: A case of extracorporeal biventricular assist devices for 295 days. 61
33530821 2021
8
Giant Cell Myocarditis Presenting with Predominant Right Ventricular Dysfunction Treated Successfully with Heart Transplantation. 61
33488035 2021
9
Heart Transplantation for Giant Cell Myocarditis: A Case Series. 61
33384178 2021
10
Giant Cell, Giant Problems: A case of giant cell myocarditis complicated by cardiogenic shock and refractory ventricular tachycardia managed with a mechanical circulatory support device. 61
33574004 2021
11
Outcomes of Mechanical Circulatory Support for Giant Cell Myocarditis: A Systematic Review. 61
33271929 2020
12
An immunosuppression tightrope: Successful heart transplantation after giant cell myocarditis in a patient with HIV complicated by recurrent giant cell myocarditis and Kaposi sarcoma. 61
33067104 2020
13
Giant cell myositis and myocarditis revisited. 61
33458585 2020
14
[ANMCO/SIC Consensus document on the management of myocarditis]. 61
33231216 2020
15
Giant cell myocarditis causing sudden death in a patient with sarcoidosis. 61
33344333 2020
16
Giant cell myocarditis in an older patient - reassessing the threshold for endomyocardial biopsy. 61
32644298 2020
17
Evaluation of Myocardial Gene Expression Profiling for Superior Diagnosis of Idiopathic Giant-Cell Myocarditis and Clinical Feasibility in a Large Cohort of Patients with Acute Cardiac Decompensation. 61
32825201 2020
18
Giant Cell Myocarditis: Still the Deadly Giant. 61
32840493 2020
19
Intravenous Immunoglobulin Therapy in Myocarditis. 61
33463100 2020
20
Long-term outcome and its predictors in giant cell myocarditis. Letter regarding the article 'Long-term outcome and its predictors in giant cell myocarditis'. 61
32613726 2020
21
Virome Sequencing in Patients With Myocarditis. 61
32586108 2020
22
Low rank and primiparity increase fecal glucocorticoid metabolites across gestation in wild geladas. 61
32333913 2020
23
Idiopathic giant cell myocarditis or cardiac sarcoidosis? A retrospective audit of a nationwide case series. 61
32343481 2020
24
Haemophagocytic lymphohistiocytosis after heart transplantation: a case report. 61
32617508 2020
25
Sudden cardiac death due to ventricular fibrillation in a case of giant cell myocarditis. 61
32547658 2020
26
Inflammatory cardiomyopathies: short- and long-term outcomes after heart transplantation-a protocol for a systematic review and meta-analysis. 61
31932994 2020
27
Management of a patient presenting with giant cell myocarditis - A case report. 61
32373244 2020
28
Mechanical Circulatory Support Combined With Immunosuppression for the Treatment of Giant Cell Myocarditis - A Single-Center Experience in Japan. 61
32173690 2020
29
Clinicopathological manifestations of myocarditis in a heart failure population. 61
31896440 2020
30
Serial 18F-Fluorodeoxyglucose Positron Emission Tomography Imaging in a Patient With Giant Cell Myocarditis. 61
32000512 2020
31
A giant mystery in giant cell myocarditis: navigating diagnosis, immunosuppression, and mechanical circulatory support. 61
31872976 2020
32
Giant cell myocarditis with central diabetes insipidus: A case report. 61
31933698 2020
33
Giant Cell Myocarditis: A Time Sensitive Distant Diagnosis. 61
32133246 2020
34
Long-term continuous flow mechanical biventricular support: 9 years and counting. 61
31580433 2020
35
Sudden death in cardiac sarcoidosis: an analysis of nationwide clinical and cause-of-death registries. 61
31230070 2019
36
Sirolimus for Recurrent Giant Cell Myocarditis After Heart Transplantation: A Unique Therapeutic Strategy. 61
29889677 2019
37
An autopsy case of giant cell myocarditis showing shared pathology in the myocardium and skeletal muscles. 61
31202079 2019
38
The spectrum of myocarditis: from pathology to the clinics. 61
31297595 2019
39
Successful Triple Combination Immunosuppressive Therapy with Prednisolone, Cyclosporine, and Mycophenolate Mofetil to Treat Recurrent Giant Cell Myocarditis. 61
30918193 2019
40
Fulminant Versus Acute Nonfulminant Myocarditis in Patients With Left Ventricular Systolic Dysfunction. 61
31319912 2019
41
Importance of endomyocardial biopsy in distinguishing between cardiac sarcoidosis and giant cell myocarditis : Need to distinguish between sarcoidosis and giant cell myocarditis. 61
30470883 2019
42
Rejection in heart transplantation for cardiac sarcoidosis mimicking idiopathic giant cell myocarditis: long-term follow-up. 61
30720635 2019
43
Churg-Strauss Syndrome Presenting as Acute Necrotizing Eosinophilic Myocarditis: Concise Review of the Literature. 61
30179138 2019
44
Monomorphic Ventricular Tachycardia as a Presentation of Giant Cell Myocarditis. 61
31321103 2019
45
Clinical and Histological Response to Immunosuppressive Therapy in Giant Cell Myocarditis. 61
30637996 2019
46
Clinical perspective on the myocarditis and cardiomyopathies. 61
31842551 2019
47
Conduction Dysfunction and Near Expunction: Giant Cell Myocarditis. 61
29729236 2018
48
Therapeutic implications of a combined diagnostic workup including endomyocardial biopsy in an all-comer population of patients with heart failure: a retrospective analysis. 61
29745463 2018
49
Hemoadsorption in cardiac shock with bi ventricular failure and giant-cell myocarditis: A case report. 61
29843541 2018
50
Atrial giant cell myocarditis after atrial fibrillation ablation. 61
31020143 2018

Variations for Giant Cell Myocarditis

Expression for Giant Cell Myocarditis

Search GEO for disease gene expression data for Giant Cell Myocarditis.

Pathways for Giant Cell Myocarditis

GO Terms for Giant Cell Myocarditis

Sources for Giant Cell Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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