MCID: GNT001
MIFTS: 40

Giant Cell Reparative Granuloma

Categories: Bone diseases, Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Giant Cell Reparative Granuloma

MalaCards integrated aliases for Giant Cell Reparative Granuloma:

Name: Giant Cell Reparative Granuloma 12 15 17
Central Giant Cell Granuloma 12 54
Central Giant Cell Reparative Granuloma of Jaw 12
Granuloma, Giant Cell Reparative 70
Giant Cell Lesion of Small Bones 70
Central Giant Cell Granuloma 12
Granuloma, Giant Cell 44

Classifications:



External Ids:

Disease Ontology 12 DOID:1866
ICD9CM 34 526.3
MeSH 44 D006101
SNOMED-CT 67 15350006
ICD10 32 K10.1 M27.1
UMLS 70 C0162375 C4049867

Summaries for Giant Cell Reparative Granuloma

MalaCards based summary : Giant Cell Reparative Granuloma, also known as central giant cell granuloma, is related to root resorption and aneurysmal bone cysts, and has symptoms including pain An important gene associated with Giant Cell Reparative Granuloma is SH3BP2 (SH3 Domain Binding Protein 2), and among its related pathways/superpathways are Presynaptic function of Kainate receptors and G alpha (s) signalling events. The drugs Salmon calcitonin and Denosumab have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and lymph node, and related phenotypes are hematopoietic system and immune system

Related Diseases for Giant Cell Reparative Granuloma

Diseases related to Giant Cell Reparative Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 root resorption 30.9 TNFSF11 TNFRSF11A CALCA
2 aneurysmal bone cysts 30.7 USP6 TNFSF11 TNFRSF11A CALCA
3 hyperparathyroidism 30.7 TNFSF11 PTH CALCA
4 benign giant cell tumor 30.7 TNFSF11 TNFRSF11A SERPINA3 CALCA
5 fibrous dysplasia 30.4 TNFSF11 TNFRSF11A SH3BP2 CALCA
6 cherubism 30.4 USP6 TNFSF11 SH3BP2 CALCA
7 epulis 30.4 SERPINA3 CD68
8 osteitis fibrosa 30.3 PTH CALCA
9 exophthalmos 30.1 NF1 CD68
10 primary hyperparathyroidism 30.1 TNFSF11 PTH CALCA
11 chondroblastoma 30.0 USP6 TNFSF11 SERPINA3
12 mammary paget's disease 30.0 TNFSF11 TNFRSF11A PTH CALCA
13 ossifying fibroma 29.7 USP6 SERPINA3 PTH NF1
14 bone disease 29.6 TNFSF11 TNFRSF11A PTH CALCA
15 paget's disease of bone 29.6 TNFSF11 TNFRSF11A PTH CALCA
16 fibroma 29.5 USP6 SERPINA3 NF1 CD68
17 bone resorption disease 29.1 TNFSF11 TNFRSF11A SERPINA3 PTH CALCR CALCA
18 bone giant cell tumor 28.5 USP6 TNFSF11 TNFRSF11A SH3BP2 SERPINA3 PTH
19 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
20 chondroma 10.3
21 enchondroma 10.3
22 perianal hematoma 10.3 NF1 CALCA
23 pancreatic somatostatinoma 10.2 NF1 CALCA
24 somatostatinoma 10.2 NF1 CALCA
25 otitis media 10.2
26 osteogenic sarcoma 10.2
27 peripheral nerve schwannoma 10.2 SERPINA3 NF1
28 chronic pyelonephritis 10.2 SERPINA3 CALCA
29 cerebellar astrocytoma 10.2 SERPINA3 NF1
30 autonomic nervous system benign neoplasm 10.2 NF1 CALCA
31 peripheral nervous system benign neoplasm 10.2 NF1 CALCA
32 syringomyelia 10.2 NF1 CALCA
33 kummell's disease 10.2 TNFSF11 CALCA
34 ectopic cushing syndrome 10.2 NR3C1 CALCA
35 multiple endocrine neoplasia, type iib 10.2 NF1 CALCA
36 osteonecrosis 10.2
37 melorheostosis 10.2
38 juvenile ossifying fibroma 10.2
39 persistent generalized lymphadenopathy 10.1 SERPINA3 NF1
40 conventional central osteosarcoma 10.1 USP6 SERPINA3
41 polyarticular onset juvenile idiopathic arthritis 10.1 TNFSF11 TNFRSF11A
42 substernal goiter 10.1 PTH CALCA
43 hemophilic arthropathy 10.1 TNFSF11 TNFRSF11A
44 disseminated chorioretinitis 10.1 TNFSF11 TNFRSF11A
45 atypical depressive disorder 10.1 SERPINA3 NR3C1
46 steroid-induced glaucoma 10.1 SERPINA3 NR3C1
47 acute stress disorder 10.1 SERPINA3 NR3C1
48 hypervitaminosis d 10.1 PTH CALCA
49 endemic goiter 10.1 PTH CALCA
50 renal cell carcinoma, nonpapillary 10.1

Graphical network of the top 20 diseases related to Giant Cell Reparative Granuloma:



Diseases related to Giant Cell Reparative Granuloma

Symptoms & Phenotypes for Giant Cell Reparative Granuloma

UMLS symptoms related to Giant Cell Reparative Granuloma:


pain

MGI Mouse Phenotypes related to Giant Cell Reparative Granuloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 CALCR CD68 NF1 NR3C1 PTH SH3BP2
2 immune system MP:0005387 9.76 CALCR CD68 NF1 NR3C1 PTH SH3BP2
3 limbs/digits/tail MP:0005371 9.43 CALCR NF1 PTH SH3BP2 TNFRSF11A TNFSF11
4 skeleton MP:0005390 9.23 CALCR CD68 NF1 NR3C1 PTH SH3BP2

Drugs & Therapeutics for Giant Cell Reparative Granuloma

Drugs for Giant Cell Reparative Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salmon calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
2
Denosumab Approved Phase 2 615258-40-7
3
Calcitonin gene-related peptide Investigational Phase 2 83652-28-2
4 Vasodilator Agents Phase 2
5 Hormones Phase 2
6 Katacalcin Phase 2
7 calcitonin Phase 2
8 Calcium, Dietary Phase 2
9
Calcium Nutraceutical Phase 2 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Aggressive Central Giant Cell Granuloma Completed NCT02358304 Phase 2 nasal spray calcitonin;Placebo
2 An Open-label, Multi-center, Phase 2 Study of Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab

Search NIH Clinical Center for Giant Cell Reparative Granuloma

Cochrane evidence based reviews: granuloma, giant cell

Genetic Tests for Giant Cell Reparative Granuloma

Anatomical Context for Giant Cell Reparative Granuloma

MalaCards organs/tissues related to Giant Cell Reparative Granuloma:

40
Bone, Endothelial, Lymph Node, Heart, Smooth Muscle, Thyroid, Temporal Lobe

Publications for Giant Cell Reparative Granuloma

Articles related to Giant Cell Reparative Granuloma:

(show top 50) (show all 648)
# Title Authors PMID Year
1
Interventions for central giant cell granuloma (CGCG) of the jaws. 54 61
19821413 2009
2
Central giant cell lesion of the jaw: nonsurgical treatment with calcitonin nasal spray. 61 54
19464656 2009
3
Calcitonin: a non-invasive giant cells therapy. 54 61
18466982 2008
4
DNA analysis of the SH3BP2 gene in patients with aggressive central giant cell granuloma. 61 54
16713042 2007
5
Calcitonin nasal spray for treatment of central giant cell granuloma: clinical, radiological, and histological findings and immunohistochemical expression of calcitonin and glucocorticoid receptors. 61 54
17630098 2007
6
Giant cell reparative granuloma of the temporal bone treated with calcitonin. 54 61
16788413 2006
7
Calcitonin therapy in central giant cell granuloma of the jaw: a randomized double-blind placebo-controlled study. 61 54
16829031 2006
8
Limited regression of central giant cell granuloma by interferon alpha after failed calcitonin therapy: a report of 2 cases. 54 61
16584870 2006
9
Immunohistochemical expression of glucocorticoid and calcitonin receptors as a tool for selecting therapeutic approach in central giant cell granuloma of the jawbones. 61 54
16580179 2006
10
Immunohistochemical expression of RANK, GRalpha and CTR in central giant cell granuloma of the jaws. 54 61
15878752 2005
11
Calcitonin therapy for central giant cell granuloma. 54 61
12796868 2003
12
Neurofibromatosis 1: a novel NF1 mutation in an 11-year-old girl with a giant cell granuloma. 61 54
12822827 2003
13
Treatment of central giant cell granuloma of the jaw with calcitonin. 61 54
10535540 1999
14
[Calcitonin therapy in large or recurrent central giant cell granulomas of the lower jaw]. 61 54
9132608 1997
15
A systematic review of the clinical and radiographic features of hybrid central giant cell granuloma lesions of the jaws. 61
32730731 2021
16
Successful denosumab treatment for central giant cell granuloma in a 9-year-old child. 61
33760257 2021
17
Treatment of central giant cell granuloma in children with denosumab. 61
33089644 2021
18
Mandibular Reconstruction Following Central Giant Cell Granuloma Resection in Primary Dentition: A Case for the Use of a Costochondral Graft. 61
32757776 2021
19
Denosumab for the management of central giant cell granuloma of the jaws-a case series. 61
33468436 2021
20
Central giant cell granuloma of the maxilla: Long-term follow-up of a patient treated with an adjuvant corticosteroid. 61
33471401 2021
21
Central giant cell granuloma mimicking a periapical lesion of endodontic origin: A case report. 61
32820589 2020
22
Retinal ischemia following mandible tumor treatment with steroid injection. 61
33470284 2020
23
SATB2 is not a reliable diagnostic marker for distinguishing between oral osteosarcoma and fibro-osseous lesions of the jaws. 61
33309262 2020
24
Letter to the editor: giant cell reparative granuloma of the temporal bone. 61
33010020 2020
25
A Comparative Analysis of p63 Expression in Giant Cell Tumour (GCT), Central Giant Cell Granuloma (CGCG) and Peripheral Giant Cell Granuloma (PGCG). 61
31873936 2020
26
Pediatric Mandibular Central Giant Cell Granuloma: Neoadjuvant Immunotherapy to Minimize Surgical Resection. 61
32969939 2020
27
Management of recurrent central giant cell granuloma of mandible using intralesional corticosteroid with long-term follow-up. 61
32928838 2020
28
[Surgery technique of combined different infratemporal fossa approaches for lesions in lateral skull base]. 61
32911883 2020
29
Pathologic evaluation of the solid variant of aneurysmal bone cysts with USP6 rearrangement with an emphasis on the frequent diagnostic pitfalls. 61
32342641 2020
30
Giant Cell Reparative Granuloma of Parotid Region Infiltrating the Zygomatic Bone: A case report. 61
32637090 2020
31
Immunohistochemical expression of stem cell markers OCT-4 and SOX-2 in giant cell tumor, central giant cell granuloma, and peripheral giant cell granuloma. 61
32493681 2020
32
"Radiographic demonstration of association of ubernaculum Dentis (Gubernaculum tract) in odontogenic cysts and tumors"-A CBCT finding. 61
33273768 2020
33
Central giant cell granuloma: A clinicopathological and immunohistochemical study of macrophages, blood vessels, lymphatic vessels and regulatory proteins. 61
32339965 2020
34
Central Giant Cell Granuloma Treated with Intralesional Corticosteroid Injections and Bisphosphonates: A Long-Term Follow-Up Case Study. 61
31297738 2020
35
Giant cell reparative granuloma of the nasal cavity: a rare site of presentation with review of literature. 61
33344278 2020
36
Cervical-Thoracic Epidural Giant Cell Reparative Granuloma: Case Report and Review of the Literature. 61
31931251 2020
37
Intramandibular plexiform schwannoma presenting as a nonspecific benign lesion: How specific can we be? A case report with a review of the literature. 61
32719282 2020
38
Soft Tissue Special Issue: Giant Cell-Rich Lesions of the Head and Neck Region. 61
31950466 2020
39
Giant cell reparative granuloma of the mandible with an aggressive radiological appearance. 61
31850797 2020
40
Incidental findings in a consecutive series of digital panoramic radiographs. 61
32206621 2020
41
Response to a letter to the editor concerning "Giant Cell Reparative Granuloma of the Scapula: report of a case and literature review". 61
31642972 2020
42
Commentary to: Giant cell reparative granuloma of the scapula: report of a case and literature review. 61
31712837 2020
43
Central giant cell granuloma of the mandibular condyle: A rare case and a literature review. 61
31909260 2020
44
Maxillary Giant Cell Granuloma: A Long-Term Follow-Up. 61
31012347 2020
45
Giant Cell Lesions of the Jaws:A Review and Comparative Histopathological Study. 61
32030708 2020
46
Explanation for different behavior of peripheral and central giant cell granuloma by CD44 and CD34 immunostaining. 61
31433127 2019
47
Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study. 61
31408546 2019
48
Use of Denosumab in Children With Osteoclast Bone Dysplasias: Report of Three Cases. 61
31687646 2019
49
[Unique Experience of Cherubism Targeted Therapy]. 61
31747153 2019
50
[Giant cell reparative granuloma of the temporal bone: A case report]. 61
31570683 2019

Variations for Giant Cell Reparative Granuloma

Expression for Giant Cell Reparative Granuloma

Search GEO for disease gene expression data for Giant Cell Reparative Granuloma.

Pathways for Giant Cell Reparative Granuloma

GO Terms for Giant Cell Reparative Granuloma

Biological processes related to Giant Cell Reparative Granuloma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.7 TNFRSF11A PTH CALCA
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.58 PTH CALCR CALCA
3 activation of adenylate cyclase activity GO:0007190 9.54 CALCR CALCA
4 calcium ion homeostasis GO:0055074 9.51 TNFSF11 PTH
5 bone resorption GO:0045453 9.49 TNFSF11 PTH
6 negative regulation of ossification GO:0030279 9.48 CALCR CALCA
7 positive regulation of bone resorption GO:0045780 9.46 TNFSF11 TNFRSF11A
8 mammary gland alveolus development GO:0060749 9.43 TNFSF11 TNFRSF11A
9 monocyte chemotaxis GO:0002548 9.43 TNFSF11 TNFRSF11A CALCA
10 amylin receptor signaling pathway GO:0097647 9.37 CALCR CALCA
11 TNFSF11-mediated signaling pathway GO:0071847 9.32 TNFSF11 TNFRSF11A
12 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.16 TNFSF11 TNFRSF11A
13 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFSF11 TNFRSF11A
14 osteoclast differentiation GO:0030316 8.8 TNFSF11 TNFRSF11A CALCR

Sources for Giant Cell Reparative Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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