MCID: GNT001
MIFTS: 41

Giant Cell Reparative Granuloma

Categories: Bone diseases, Cancer diseases, Gastrointestinal diseases, Oral diseases
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Aliases & Classifications for Giant Cell Reparative Granuloma

MalaCards integrated aliases for Giant Cell Reparative Granuloma:

Name: Giant Cell Reparative Granuloma 11 14 16
Central Giant Cell Reparative Granuloma of Jaw 11 33
Central Giant Cell Granuloma 11 53
Granuloma, Giant Cell Reparative 71
Giant Cell Lesion of Small Bones 71
Central Giant Cell Granuloma 11
Giant Cell Granuloma, Nos 33
Granuloma, Giant Cell 43

Classifications:



External Ids:

Disease Ontology 11 DOID:1866
ICD9CM 34 526.3
MeSH 43 D006101
NCIt 49 C173930
SNOMED-CT 68 15350006
ICD10 31 K10.1
ICD11 33 1844801204
UMLS 71 C0162375 C4049867

Summaries for Giant Cell Reparative Granuloma

MalaCards based summary: Giant Cell Reparative Granuloma, also known as central giant cell reparative granuloma of jaw, is related to hyperparathyroidism and root resorption, and has symptoms including pain An important gene associated with Giant Cell Reparative Granuloma is SH3BP2 (SH3 Domain Binding Protein 2), and among its related pathways/superpathways are G alpha (s) signalling events and Clock-controlled autophagy in bone metabolism. The drugs Salmon calcitonin and Denosumab have been mentioned in the context of this disorder. Affiliated tissues include bone, lymph node and temporal lobe, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Giant Cell Reparative Granuloma

Diseases related to Giant Cell Reparative Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
# Related Disease Score Top Affiliating Genes
1 hyperparathyroidism 30.6 TNFSF11 PTH CALCA
2 root resorption 30.5 TNFSF11 TNFRSF11A CALCR CALCA
3 fibrous dysplasia 30.4 TNFSF11 TNFRSF11A CALCA
4 osteitis fibrosa 30.4 PTH CALCA
5 epulis 30.3 SH3BP2 SERPINA3 CD68
6 cherubism 30.2 USP6 TNFSF11 SH3BP2 CALCA
7 cutaneous fibrous histiocytoma 30.1 SERPINA3 CD68
8 primary hyperparathyroidism 30.0 TNFSF11 PTH CALCA
9 mammary paget's disease 29.9 TNFSF11 TNFRSF11A PTH CALCA
10 fibroma 29.8 USP6 SERPINA3 NF1 CD68
11 osteomyelitis 29.7 TNFSF11 TNFRSF11A CALCA
12 osteomalacia 29.7 TNFSF11 PTH CALCA
13 paget's disease of bone 29.6 TNFSF11 TNFRSF11A PTH CALCA
14 bone disease 29.3 TNFSF11 TNFRSF11A SERPINA3 PTH CALCA
15 ossifying fibroma 29.3 USP6 SH3BP2 SERPINA3 PTH NF1 H3-3A
16 bone giant cell tumor 28.8 USP6 TNFSF11 SH3BP2 SERPINA3 PTH H3-3A
17 benign giant cell tumor 28.7 USP6 TNFSF11 TNFRSF11A SERPINA3 H3-3A CD68
18 aneurysmal bone cysts 10.8
19 enchondroma 10.3
20 multiple mucosal neuroma 10.3 NF1 CALCA
21 perianal hematoma 10.3 NF1 CALCA
22 otitis media 10.3
23 osteogenic sarcoma 10.3
24 congenital hemidysplasia with ichthyosiform erythroderma and limb defects 10.2
25 osteonecrosis 10.2
26 children's interstitial lung disease 10.2
27 horner's syndrome 10.2 NF1 CALCA
28 peripheral nerve schwannoma 10.2 SERPINA3 NF1
29 tetanic cataract 10.2 PTH CALCA
30 substernal goiter 10.2 PTH CALCA
31 kohler's disease 10.2 PTH CALCA
32 autonomic nervous system benign neoplasm 10.2 NF1 CALCA
33 isthmus cancer 10.2 PTH CALCA
34 peripheral nervous system benign neoplasm 10.2 NF1 CALCA
35 malignant spindle cell melanoma 10.2 SERPINA3 NF1
36 hypervitaminosis d 10.2 PTH CALCA
37 hypercalcemia, infantile, 1 10.2 PTH CALCA
38 endemic goiter 10.2 PTH CALCA
39 plummer's disease 10.2 PTH CALCA
40 nontoxic goiter 10.2 PTH CALCA
41 hemifacial hyperplasia 10.2
42 ameloblastoma 10.2
43 melorheostosis 10.2
44 juvenile ossifying fibroma 10.2
45 lipoadenoma 10.2 SERPINA3 PTH
46 ectopic cushing syndrome 10.2 NR3C1 CALCA
47 bursitis 10.2 PTH CALCA
48 multiple endocrine neoplasia, type iib 10.1 NF1 CALCA
49 spinal cord astrocytoma 10.1 NF1 H3-3A
50 pilocytic astrocytoma of cerebellum 10.1 NF1 H3-3A

Graphical network of the top 20 diseases related to Giant Cell Reparative Granuloma:



Diseases related to Giant Cell Reparative Granuloma

Symptoms & Phenotypes for Giant Cell Reparative Granuloma

UMLS symptoms related to Giant Cell Reparative Granuloma:


pain

MGI Mouse Phenotypes related to Giant Cell Reparative Granuloma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 CALCA CALCR H3-3A NF1 NR3C1 PTH
2 immune system MP:0005387 9.97 CALCR CD68 NF1 NR3C1 PTH SERPINA3
3 limbs/digits/tail MP:0005371 9.88 CALCR NF1 PTH SH3BP2 TNFRSF11A TNFSF11
4 skeleton MP:0005390 9.81 CALCA CALCR CD68 NF1 NR3C1 PTH
5 respiratory system MP:0005388 9.73 CALCA NF1 NR3C1 SH3BP2 TNFRSF11A TNFSF11
6 hematopoietic system MP:0005397 9.61 CALCR CD68 NF1 NR3C1 PTH SERPINA3
7 integument MP:0010771 9.17 CALCA NF1 NR3C1 SERPINA3 SH3BP2 TNFRSF11A

Drugs & Therapeutics for Giant Cell Reparative Granuloma

Drugs for Giant Cell Reparative Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salmon calcitonin Approved, Investigational Phase 2 47931-85-1 155817456
2
Denosumab Approved Phase 2 615258-40-7
3
Calcitonin gene-related peptide Investigational Phase 2 83652-28-2 91976570
4
Calcitonin Phase 2
5 Hormones Phase 2
6 Vasodilator Agents Phase 2
7 Calcium, Dietary Phase 2
8 Katacalcin Phase 2 16172926
9
Calcium Nutraceutical Phase 2 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Aggressive Central Giant Cell Granuloma Completed NCT02358304 Phase 2 nasal spray calcitonin;Placebo
2 An Open-label, Multi-center, Phase 2 Study of Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab

Search NIH Clinical Center for Giant Cell Reparative Granuloma

Cochrane evidence based reviews: granuloma, giant cell

Genetic Tests for Giant Cell Reparative Granuloma

Anatomical Context for Giant Cell Reparative Granuloma

Organs/tissues related to Giant Cell Reparative Granuloma:

MalaCards : Bone, Lymph Node, Temporal Lobe, Smooth Muscle, Endothelial, Thyroid, Heart

Publications for Giant Cell Reparative Granuloma

Articles related to Giant Cell Reparative Granuloma:

(show top 50) (show all 694)
# Title Authors PMID Year
1
Interventions for central giant cell granuloma (CGCG) of the jaws. 53 62
19821413 2009
2
Central giant cell lesion of the jaw: nonsurgical treatment with calcitonin nasal spray. 53 62
19464656 2009
3
Calcitonin: a non-invasive giant cells therapy. 53 62
18466982 2008
4
DNA analysis of the SH3BP2 gene in patients with aggressive central giant cell granuloma. 53 62
16713042 2007
5
Calcitonin nasal spray for treatment of central giant cell granuloma: clinical, radiological, and histological findings and immunohistochemical expression of calcitonin and glucocorticoid receptors. 53 62
17630098 2007
6
Giant cell reparative granuloma of the temporal bone treated with calcitonin. 53 62
16788413 2006
7
Limited regression of central giant cell granuloma by interferon alpha after failed calcitonin therapy: a report of 2 cases. 53 62
16584870 2006
8
Calcitonin therapy in central giant cell granuloma of the jaw: a randomized double-blind placebo-controlled study. 53 62
16829031 2006
9
Immunohistochemical expression of glucocorticoid and calcitonin receptors as a tool for selecting therapeutic approach in central giant cell granuloma of the jawbones. 53 62
16580179 2006
10
Immunohistochemical expression of RANK, GRalpha and CTR in central giant cell granuloma of the jaws. 53 62
15878752 2005
11
Calcitonin therapy for central giant cell granuloma. 53 62
12796868 2003
12
Neurofibromatosis 1: a novel NF1 mutation in an 11-year-old girl with a giant cell granuloma. 53 62
12822827 2003
13
Treatment of central giant cell granuloma of the jaw with calcitonin. 53 62
10535540 1999
14
[Calcitonin therapy in large or recurrent central giant cell granulomas of the lower jaw]. 53 62
9132608 1997
15
Significant association between FGFR1 mutation frequency and age in central giant cell granuloma. 62
36428107 2022
16
Central Giant Cell Granuloma of Maxilla: A Case Report. 62
36452637 2022
17
Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours. 62
35612673 2022
18
Central giant cell granuloma of the head & neck: A case report and systematic review. 62
34411774 2022
19
Scalloped border as a possible diagnostic aid for differentiating jaw lesions: A pictorial essay. 62
36238702 2022
20
Clinico-Pathological Characteristics, Management, and Outcome of Benign Intraosseous Maxillary Tumors in Adolescents: A Prospective Study. 62
35762625 2022
21
Giant Cell Tumor and Giant Cell Reparative Granuloma of Bone of the Head: CT and MR Imaging Findings. 62
35984022 2022
22
Novel regimen of combined intralesional triamcinolone and salmon calcitonin nasal spray to treat a large central giant cell granuloma. 62
36393951 2022
23
Central Giant Cell Granuloma in the Mandibular Condyle in a Teenager. A Case Report with Literature Review. 62
35888004 2022
24
Recurrent Mandibular Giant Cell Lesion in Neurofibromatosis Type 1: Second Hit Mutation on the NF1 Gene in the Osseous Lesion. 62
35641267 2022
25
Treatment of central giant cell granuloma with denosumab: A case report of a complicated treatment course. 62
34767309 2022
26
Regarding "Denosumab for the management of central giant cell granuloma of the jaws-a case series". 62
34657767 2022
27
Response to the comments to the Editor regarding "Denosumab for the management of central giant cell granuloma of the jaws-a case series". 62
34696943 2022
28
Cone-beam computed tomographic imaging of central giant cell granuloma: A comprehensive review. 62
35799967 2022
29
Denosumab for central giant cell granuloma in an Australian tertiary paediatric centre. 62
35331976 2022
30
Sclerostin Immunohistochemical Staining in Aggressive Maxillofacial Giant Cell Lesions: Initial Results and Potential Therapeutic Target. 62
34753866 2022
31
Pediatric Aggressive Benign Mandibular Tumors: Clinical Features and Management. 62
34387270 2022
32
Combined lesion of central giant cell granuloma and ossifying fibroma: A case report of a rare event in oral cavity. 62
35439729 2022
33
[Giant-cell tumor of bone in 2022]. 62
35523609 2022
34
[Bilateral giant cell central granuloma of the jaws in a Noonan syndrome: About one case with emphasizing on bone giant cell lesions of the jaws]. 62
35058088 2022
35
Clinical and Radiologic Response of Central Giant Cell Granuloma to Denosumab: A 6-Year Prospective Observational Study. 62
35088118 2022
36
[Experience with Denosumab in central giant-cell granuloma]. 62
35735304 2022
37
Non-surgical treatment as an alternative for the management of central giant cell granuloma: a systematic review. 62
34599398 2022
38
Hybrid odontogenic lesions: A systematic review of 203 cases reported in the literature. 62
34469012 2022
39
A Unique Case of Aggressive Central Giant Cell Granuloma in a 10-Year-Old Boy With 16p13.11 Microdeletion Syndrome. 62
36154495 2022
40
Central odontogenic fibroma in association with brown tumor of hyperparathyroidism in a patient with neurofibromatosis type 1. 62
34511348 2022
41
Pediatric Mandibular Reconstruction Using the Vascularized Fibula Free Flap: Functional Outcomes in 34 Consecutive Patients. 62
34334671 2021
42
Reconstruction of bilateral ramus-condyle unit defect using custom titanium prosthesis with preservation of both condyles. 62
34509905 2021
43
Dilemma in the Treatment of a Central Giant Cell Granuloma. 62
34740263 2021
44
An Intraosseous Giant Cell Granuloma: An Uncommon Presentation. 62
35018067 2021
45
[Multiple giant cell reparative granuloma of craniofacial bone: a case report]. 62
34666474 2021
46
Correction to: Central Giant Cell Granuloma Treated with Intralesional Corticosteroid Injections and Bisphosphonates: A Long‑Term Follow‑Up Case Study. 62
34259981 2021
47
A rare mandibular neoplasm: case report of a Central Giant Cell Granuloma. 62
34569469 2021
48
A Literature Review of the Rare Coexistence of Central Giant Cell Granuloma with Aneurysmal Bone Cyst: A Case Report. 62
34692579 2021
49
Worsening Lower Jaw Swelling and Pain in a Teenager: Differential Diagnosis and Management. 62
34722071 2021
50
Denosumab for the management of central giant cell granuloma of the jaws-a case series. 62
33468436 2021

Variations for Giant Cell Reparative Granuloma

Expression for Giant Cell Reparative Granuloma

Search GEO for disease gene expression data for Giant Cell Reparative Granuloma.

Pathways for Giant Cell Reparative Granuloma

GO Terms for Giant Cell Reparative Granuloma

Biological processes related to Giant Cell Reparative Granuloma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.19 TNFRSF11A SH3BP2 PTH NR3C1 NF1 CALCR
2 monocyte chemotaxis GO:0002548 9.8 CALCA TNFRSF11A TNFSF11
3 positive regulation of bone resorption GO:0045780 9.78 TNFSF11 TNFRSF11A
4 mammary gland alveolus development GO:0060749 9.76 TNFSF11 TNFRSF11A
5 TNFSF11-mediated signaling pathway GO:0071847 9.67 TNFSF11 TNFRSF11A
6 amylin receptor signaling pathway GO:0097647 9.58 CALCR CALCA
7 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.56 TNFSF11 TNFRSF11A
8 ossification GO:0001503 9.5 TNFSF11 TNFRSF11A CALCR CALCA
9 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.46 TNFSF11 TNFRSF11A
10 astrocyte differentiation GO:0048708 9.43 NR3C1 NF1
11 osteoclast differentiation GO:0030316 9.17 TNFSF11 TNFRSF11A NF1 CALCR

Sources for Giant Cell Reparative Granuloma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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