MCID: GNT001
MIFTS: 33

Giant Cell Reparative Granuloma

Categories: Gastrointestinal diseases, Cancer diseases, Bone diseases, Oral diseases

Aliases & Classifications for Giant Cell Reparative Granuloma

MalaCards integrated aliases for Giant Cell Reparative Granuloma:

Name: Giant Cell Reparative Granuloma 12 15
Central Giant Cell Granuloma 12 55
Central Giant Cell Reparative Granuloma of Jaw 12
Granuloma, Giant Cell Reparative 73
Giant Cell Lesion of Small Bones 73
Central Giant Cell Granuloma 12
Granuloma, Giant Cell 44

Classifications:



External Ids:

Disease Ontology 12 DOID:1866
ICD10 33 M27.1 K10.1
ICD9CM 35 526.3
MeSH 44 D006101
SNOMED-CT 68 15350006

Summaries for Giant Cell Reparative Granuloma

MalaCards based summary : Giant Cell Reparative Granuloma, also known as central giant cell granuloma, is related to fibrous dysplasia and giant cell tumor, and has symptoms including pain An important gene associated with Giant Cell Reparative Granuloma is SH3BP2 (SH3 Domain Binding Protein 2), and among its related pathways/superpathways are G alpha (s) signalling events and Osteoclast differentiation. Affiliated tissues include bone and temporal lobe, and related phenotype is limbs/digits/tail.

Related Diseases for Giant Cell Reparative Granuloma

Graphical network of the top 20 diseases related to Giant Cell Reparative Granuloma:



Diseases related to Giant Cell Reparative Granuloma

Symptoms & Phenotypes for Giant Cell Reparative Granuloma

UMLS symptoms related to Giant Cell Reparative Granuloma:


pain

MGI Mouse Phenotypes related to Giant Cell Reparative Granuloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 CALCR NF1 SH3BP2 TNFRSF11A

Drugs & Therapeutics for Giant Cell Reparative Granuloma

Search Clinical Trials , NIH Clinical Center for Giant Cell Reparative Granuloma

Cochrane evidence based reviews: granuloma, giant cell

Genetic Tests for Giant Cell Reparative Granuloma

Anatomical Context for Giant Cell Reparative Granuloma

MalaCards organs/tissues related to Giant Cell Reparative Granuloma:

41
Bone, Temporal Lobe

Publications for Giant Cell Reparative Granuloma

Articles related to Giant Cell Reparative Granuloma:

(show top 50) (show all 180)
# Title Authors Year
1
Giant Cell Reparative Granuloma Mimicking Aneurysmal Bone Cyst in Proximal Phalanx of Toe. ( 28435549 )
2016
2
A rapidly enlarging maxillary lesion. Left maxillary giant cell reparative granuloma (GCRG). ( 25590797 )
2015
3
Multifocal giant cell reparative granuloma involving maxilla and mandible: a rare entity. ( 26497714 )
2015
4
Giant cell reparative granuloma of the hallux following enchondroma. ( 26985281 )
2015
5
Effect of denosumab on recurrent giant cell reparative granuloma of the lumbar spine. ( 25955096 )
2015
6
Giant Cell Reparative Granuloma of the Temporal Bone Treated With Calcitonin--10 Years on. ( 25985319 )
2015
7
USP6 gene rearrangements occur preferentially in giant cell reparative granulomas of the hands and feet but not in gnathic location. ( 24742829 )
2014
8
Peripheral giant cell reparative granuloma of maxilla in a patient with aggressive periodontitis. ( 25284527 )
2014
9
Aggressive giant cell reparative granuloma of the nasal cavity. ( 23585980 )
2013
10
Giant cell reparative granuloma of the orbit. ( 23511994 )
2013
11
A case of pseudogout of the temporomandibular joint with giant cell reparative granuloma of the temporal bone. ( 23969082 )
2013
12
Double localization of Giant Cell Reparative Granuloma of the bone in the same finger Differential diagnosis and treatment. ( 23917683 )
2013
13
Giant cell reparative granuloma of the temporal bone successfully resected with preservation of hearing. ( 23750668 )
2013
14
Giant cell reparative granuloma of the pediatric cranium: case report and review of the literature. ( 23943191 )
2013
15
Immunophenotype of Dental Implant-Associated Peripheral Giant Cell Reparative Granuloma in a representative case report. ( 24059329 )
2013
16
Central giant cell reparative granuloma of the ethmoids with bilateral proptosis and intracranial extension. ( 23460226 )
2013
17
Giant cell reparative granuloma of the sphenoid: Case report and review of the literature. ( 23230521 )
2012
18
A novel t(6;13)(q15;q34) translocation in a giant cell reparative granuloma (solid aneurysmal bone cyst). ( 22285042 )
2012
19
Giant cell-rich osteosarcoma or giant cell reparative granuloma of the mandible? ( 21586969 )
2011
20
Giant cell reparative granuloma of the proximal phalanx: A case report and literature review. ( 22654539 )
2011
21
Giant cell reparative granuloma in the temporal bone of the skull base: report of two cases. ( 21772802 )
2010
22
Giant cell reparative granuloma in the mandible. ( 20549093 )
2010
23
Giant cell reparative granuloma of nasal cavity, a case report. ( 19501517 )
2010
24
Idiopathic bilateral central giant cell reparative granuloma of jaws: a case report and literature review. ( 20219254 )
2010
25
Metastasis of high grade renal cell carcinoma, clear cell type, in fibrous dysplasia with superimposed giant cell reparative granuloma. ( 20387711 )
2009
26
Mandible giant-cell reparative granuloma. ( 19784432 )
2009
27
Giant cell reparative granuloma of the axis. ( 19847766 )
2009
28
Giant cell tumour and central giant cell reparative granuloma of the skull: do these represent ends of a spectrum? A case report and literature review. ( 19011995 )
2009
29
Giant cell reparative granuloma of the cranial vault-case report and review of literature. ( 18291468 )
2009
30
Giant cell reparative granuloma of the temporal bone. ( 19224123 )
2009
31
Giant cell reparative granuloma of the proximal tibia: a case report. ( 19126908 )
2008
32
Re: is giant cell reparative granuloma of the hand undertreated? ( 18443074 )
2008
33
Giant cell reparative granuloma of the orbits, maxillae and mandible. ( 18722171 )
2008
34
Giant cell reparative granuloma in the mandible--case report and review of the literature. ( 18807393 )
2008
35
Giant cell reparative granuloma of the middle phalanx of the foot: a review and case report. ( 19239873 )
2008
36
Giant cell reparative granuloma of foot. ( 19087067 )
2008
37
Giant cell reparative granuloma concurrent with squamous cell carcinoma of the temporal bone: a case report and review of the literature. ( 17375645 )
2007
38
Unstable translocation (8;22) in a case of giant cell reparative granuloma. ( 17693193 )
2007
39
Alternative surgical treatment for giant-cell reparative granuloma in the metacarpal, using phenol and ethanol adjuvant therapy. ( 17606072 )
2007
40
Central giant cell reparative granuloma of the mandible caused by a molar tooth extraction: special reference to the maneuver of drilling the surgical field. ( 16246431 )
2006
41
Temporal giant cell reparative granuloma: a reappraisal of pathology and imaging features. ( 16971609 )
2006
42
Giant cell reparative granuloma of the sphenoid bone. ( 16971612 )
2006
43
Advanced giant cell reparative granuloma of the mandible: radiological features and surgical treatment. ( 17063987 )
2006
44
Giant cell reparative granuloma of the temporal bone treated with calcitonin. ( 16788413 )
2006
45
Clinicopathological review: giant cell reparative granuloma of the orbit. ( 16239891 )
2005
46
Giant cell reparative granuloma of posterior ethmoid: A case report. ( 23120208 )
2005
47
Giant cell reparative granuloma of the orbit. ( 16304531 )
2005
48
Giant cell reparative granuloma of the nasal cavity. ( 15313721 )
2004
49
Giant-cell reparative granuloma of the hands and feet. ( 14763535 )
2004
50
Giant cell reparative granuloma originating from the ethmoid sinus. ( 12560155 )
2003

Variations for Giant Cell Reparative Granuloma

Expression for Giant Cell Reparative Granuloma

Search GEO for disease gene expression data for Giant Cell Reparative Granuloma.

Pathways for Giant Cell Reparative Granuloma

Pathways related to Giant Cell Reparative Granuloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.32 CALCA CALCR
2 11.06 CALCR TNFRSF11A
3 10.45 CALCA CALCR TNFRSF11A

GO Terms for Giant Cell Reparative Granuloma

Biological processes related to Giant Cell Reparative Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.46 CALCA CALCR
2 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.43 CALCA CALCR
3 monocyte chemotaxis GO:0002548 9.4 CALCA TNFRSF11A
4 activation of adenylate cyclase activity GO:0007190 9.37 CALCA CALCR
5 osteoclast differentiation GO:0030316 9.32 CALCR TNFRSF11A
6 negative regulation of osteoclast differentiation GO:0045671 9.26 CALCA NF1
7 negative regulation of ossification GO:0030279 9.16 CALCA CALCR
8 positive regulation of cAMP metabolic process GO:0030816 8.96 CALCA CALCR
9 amylin receptor signaling pathway GO:0097647 8.62 CALCA CALCR

Sources for Giant Cell Reparative Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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