MCID: GNT001
MIFTS: 39

Giant Cell Reparative Granuloma

Categories: Bone diseases, Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Giant Cell Reparative Granuloma

MalaCards integrated aliases for Giant Cell Reparative Granuloma:

Name: Giant Cell Reparative Granuloma 12 15
Central Giant Cell Granuloma 12 55
Central Giant Cell Reparative Granuloma of Jaw 12
Granuloma, Giant Cell Reparative 73
Giant Cell Lesion of Small Bones 73
Central Giant Cell Granuloma 12
Granuloma, Giant Cell 44

Classifications:



External Ids:

Disease Ontology 12 DOID:1866
ICD10 33 M27.1 K10.1
ICD9CM 35 526.3
MeSH 44 D006101
SNOMED-CT 68 15350006

Summaries for Giant Cell Reparative Granuloma

MalaCards based summary : Giant Cell Reparative Granuloma, also known as central giant cell granuloma, is related to giant cell tumor and fibrous dysplasia, and has symptoms including pain An important gene associated with Giant Cell Reparative Granuloma is SH3BP2 (SH3 Domain Binding Protein 2), and among its related pathways/superpathways are G alpha (s) signalling events and Osteoclast differentiation. Affiliated tissues include bone, temporal lobe and testes, and related phenotype is limbs/digits/tail.

Related Diseases for Giant Cell Reparative Granuloma

Diseases related to Giant Cell Reparative Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 giant cell tumor 30.6 CALCA TNFRSF11A
2 fibrous dysplasia 30.3 CALCA SH3BP2
3 paget's disease of bone 30.0 CALCA TNFRSF11A
4 aneurysmal bone cysts 29.9 CALCA TNFRSF11A USP6
5 cherubism 10.3
6 ossifying fibroma 10.2
7 noonan syndrome 1 10.1
8 pseudo-turner syndrome 10.1
9 renal cell carcinoma, nonpapillary 10.0
10 aggressive periodontitis 10.0
11 squamous cell carcinoma 10.0
12 transitional cell carcinoma 10.0
13 periodontitis 10.0
14 enchondroma 10.0
15 paget disease of bone 5, juvenile-onset 10.0 CALCA TNFRSF11A
16 duodenal somatostatinoma 10.0 CALCA NF1
17 amyloid tumor 10.0 CALCA NF1
18 ameloblastoma 10.0
19 hyperparathyroidism 10.0
20 root resorption 10.0 CALCA TNFRSF11A
21 brachial plexus lesion 10.0 CALCA NF1
22 multiple endocrine neoplasia, type iia 10.0 CALCA NF1
23 bone giant cell tumor 10.0 CALCA CALCR
24 multiple endocrine neoplasia 10.0 CALCA NF1
25 bone resorption disease 10.0 CALCA TNFRSF11A
26 bone remodeling disease 10.0 CALCA TNFRSF11A
27 moyamoya disease 1 9.9 CALCR NF1
28 epulis 9.9
29 neurofibromatosis, type i 9.9
30 otitis media 9.9
31 ciliary dyskinesia, primary, 1 9.9
32 pycnodysostosis 9.9
33 neurofibromatosis-noonan syndrome 9.9
34 kartagener syndrome 9.9
35 primary ciliary dyskinesia 9.9
36 osteomyelitis 9.9
37 rickets 9.9
38 primary hyperparathyroidism 9.9
39 central retinal artery occlusion 9.9
40 melorheostosis 9.9
41 retinal artery occlusion 9.9
42 hard palate cancer 9.9
43 periostitis 9.9
44 keratocystic odontogenic tumor 9.9
45 thyroid carcinoma, familial medullary 9.8 CALCA CALCR
46 osteoporosis 9.7 CALCA CALCR TNFRSF11A

Graphical network of the top 20 diseases related to Giant Cell Reparative Granuloma:



Diseases related to Giant Cell Reparative Granuloma

Symptoms & Phenotypes for Giant Cell Reparative Granuloma

UMLS symptoms related to Giant Cell Reparative Granuloma:


pain

MGI Mouse Phenotypes related to Giant Cell Reparative Granuloma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 8.92 CALCR NF1 SH3BP2 TNFRSF11A

Drugs & Therapeutics for Giant Cell Reparative Granuloma

Search Clinical Trials , NIH Clinical Center for Giant Cell Reparative Granuloma

Cochrane evidence based reviews: granuloma, giant cell

Genetic Tests for Giant Cell Reparative Granuloma

Anatomical Context for Giant Cell Reparative Granuloma

MalaCards organs/tissues related to Giant Cell Reparative Granuloma:

41
Bone, Temporal Lobe, Testes, Thyroid, Endothelial, Smooth Muscle

Publications for Giant Cell Reparative Granuloma

Articles related to Giant Cell Reparative Granuloma:

(show top 50) (show all 366)
# Title Authors Year
1
Case Reports of a Giant Cell Reparative Granuloma and a Giant Cell Tumor on Temporal Bone. ( 30203809 )
2018
2
Denosumab as a Treatment Alternative for Central Giant Cell Granuloma: A Long-Term Retrospective Cohort Study. ( 29035698 )
2018
3
Evaluation of the osteopontin in oral peripheral and central giant cell granuloma. ( 29567878 )
2018
4
Central Giant Cell Granuloma with Aneurysmal Bone Cyst in a 28-Year Male Patient: A Rare Concurrence. ( 29866246 )
2018
5
Radiographic Diagnosis of a Central Giant Cell Granuloma Using Advanced Imaging: Cone Beam Computed Tomography. ( 30087811 )
2018
6
Comparative Study of Correlation between Angiogenesis Markers (CD31) and Ki67 Marker with Behavior of Aggressive and Nonaggressive Central Giant Cell Granuloma with Immunohistochemistry Technique ( 30139237 )
2018
7
Clinicopathological profile of central giant cell granulomas: An institutional experience and study of immunohistochemistry expression of p63 in central giant cell granuloma. ( 30158768 )
2018
8
Bilateral Central Giant Cell Granuloma of the mandibular angle in three females from the same family. ( 30180903 )
2018
9
Coordinated pediatric reconstruction and rehabilitation of maxillary central giant cell granuloma: A case report. ( 30243428 )
2018
10
Cellular cannibalism in giant cells of central giant cell granuloma of jaw bones and giant cell tumors of long bones. ( 26991690 )
2017
11
Re: Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws?-a response. ( 27553895 )
2017
12
Re: Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? ( 27939591 )
2017
13
Pharmacological and surgical therapy for the central giant cell granuloma: A long-term retrospective cohort study. ( 28087284 )
2017
14
A central giant cell granuloma in posterior part of maxilla-A case report. ( 28089322 )
2017
15
Age and Expression of CD163 and Colony-Stimulating Factor 1 Receptor (CD115) Are Associated With the Biological Behavior of Central Giant Cell Granuloma. ( 28161361 )
2017
16
Concomitant Central Giant Cell Granuloma and Aneurysmal Bone Cyst in a Young Child. ( 28480084 )
2017
17
A comparative study of osteopontin and MMP-2 protein expression in peripheral and central giant cell granuloma of the jaws. ( 29339027 )
2017
18
Giant Cell Reparative Granuloma Mimicking Aneurysmal Bone Cyst in Proximal Phalanx of Toe. ( 28435549 )
2016
19
Management of central giant cell granuloma of the jaws with intralesional steroid injection and review of the literature. ( 26481917 )
2016
20
Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial. ( 26993105 )
2016
21
Central Giant Cell Granuloma of the Mandible Requiring Multiple Treatment Modalities: A Case Report. ( 27000410 )
2016
22
Central Giant Cell Granuloma in Edentulous Maxilla. ( 27159866 )
2016
23
Regarding "Central Giant Cell Granuloma of the Mandible Requiring Multiple Treatment Modalities: A Case Report". ( 27235184 )
2016
24
A Comparative Study of Cathepsin D Expression in Peripheral and Central Giant Cell Granuloma of the Jaws by Immunohistochemistry Technique. ( 27284554 )
2016
25
Spontaneous Resolution of a Central Giant Cell Granuloma in a Child After an Incisional Biopsy: A Five-year Follow-up. ( 27620523 )
2016
26
Central Giant Cell Granuloma of Jaw with Multiple, Multifocal Recurrences. ( 27656591 )
2016
27
Comments about: "Central giant cell granuloma in children: Presentation of different therapeutic options". ( 27720727 )
2016
28
Multifocal Central Giant Cell Granuloma - A Case Report. ( 27799978 )
2016
29
A recurrent central giant cell granuloma in a young patient and orthodontic treatment: a case report. ( 27805877 )
2016
30
Simultaneous Occurrence of Central Giant Cell Granuloma and Odontogenic Keratocyst in Mandible. ( 28954952 )
2016
31
A rapidly enlarging maxillary lesion. Left maxillary giant cell reparative granuloma (GCRG). ( 25590797 )
2015
32
Multifocal giant cell reparative granuloma involving maxilla and mandible: a rare entity. ( 26497714 )
2015
33
Giant cell reparative granuloma of the hallux following enchondroma. ( 26985281 )
2015
34
Effect of denosumab on recurrent giant cell reparative granuloma of the lumbar spine. ( 25955096 )
2015
35
Giant Cell Reparative Granuloma of the Temporal Bone Treated With Calcitonin--10 Years on. ( 25985319 )
2015
36
Central giant cell granuloma of posterior maxilla: first expression of primary hyperparathyroidism. ( 25692050 )
2015
37
Tumor-induced rickets in a child with a central giant cell granuloma: a case report. ( 26009620 )
2015
38
Immunohistochemical comparison of p53, Ki-67, CD68, vimentin, α-smooth muscle actin and alpha-1-antichymotry-psin in oral peripheral and central giant cell granuloma. ( 25876945 )
2015
39
Aggressive Central Giant Cell Granuloma of the Mandible Treated With Conservative Surgical Enucleation and Interferon-α-2a: Complete Remission With Long-Term Follow-Up. ( 25985764 )
2015
40
A novel approach to the management of a central giant cell granuloma with denosumab: A case report and review of current treatments. ( 26032758 )
2015
41
Zoledronic Acid for the Treatment of Children With Refractory Central Giant Cell Granuloma. ( 26056788 )
2015
42
Central giant cell granuloma in a 4-year-old female child. ( 26381638 )
2015
43
Central giant cell granuloma located in the maxilla in a 8-year old boy. ( 26384122 )
2015
44
Peripheral giant cell reparative granuloma of maxilla in a patient with aggressive periodontitis. ( 25284527 )
2014
45
Total spontaneous regression of a central giant cell granuloma after incisional biopsy: a four-year follow-up case report. ( 24321310 )
2014
46
Nonaggressive central giant cell granuloma mimicking chronic inflammatory enlargement: a case report. ( 24401357 )
2014
47
Bilateral radiolucent lesions of the jaw in a generalized periodontitis patient. Central giant cell granuloma. ( 24440029 )
2014
48
Oral and maxillofacial pathology case of the month. Central giant cell granuloma. ( 24654392 )
2014
49
Alternative pharmacologic therapy for aggressive central giant cell granuloma: denosumab. ( 24835517 )
2014
50
Multidisciplinary approach for the rehabilitation of central giant cell granuloma: a clinical report. ( 24909482 )
2014

Variations for Giant Cell Reparative Granuloma

Expression for Giant Cell Reparative Granuloma

Search GEO for disease gene expression data for Giant Cell Reparative Granuloma.

Pathways for Giant Cell Reparative Granuloma

Pathways related to Giant Cell Reparative Granuloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.32 CALCA CALCR
2 11.06 CALCR TNFRSF11A
3 10.45 CALCA CALCR TNFRSF11A

GO Terms for Giant Cell Reparative Granuloma

Cellular components related to Giant Cell Reparative Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.8 CALCA CALCR NF1

Biological processes related to Giant Cell Reparative Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.73 CALCR NF1 SH3BP2 TNFRSF11A
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.46 CALCA CALCR
3 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.4 CALCA CALCR
4 monocyte chemotaxis GO:0002548 9.37 CALCA TNFRSF11A
5 activation of adenylate cyclase activity GO:0007190 9.32 CALCA CALCR
6 osteoclast differentiation GO:0030316 9.26 CALCR TNFRSF11A
7 negative regulation of osteoclast differentiation GO:0045671 9.16 CALCA NF1
8 negative regulation of ossification GO:0030279 8.96 CALCA CALCR
9 amylin receptor signaling pathway GO:0097647 8.62 CALCA CALCR

Sources for Giant Cell Reparative Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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