MCID: GNT001
MIFTS: 41

Giant Cell Reparative Granuloma

Categories: Bone diseases, Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Giant Cell Reparative Granuloma

MalaCards integrated aliases for Giant Cell Reparative Granuloma:

Name: Giant Cell Reparative Granuloma 12 15 17
Central Giant Cell Granuloma 12 54
Central Giant Cell Reparative Granuloma of Jaw 12
Granuloma, Giant Cell Reparative 71
Giant Cell Lesion of Small Bones 71
Central Giant Cell Granuloma 12
Granuloma, Giant Cell 43

Classifications:



External Ids:

Disease Ontology 12 DOID:1866
ICD9CM 34 526.3
MeSH 43 D006101
SNOMED-CT 67 15350006
ICD10 32 K10.1 M27.1
UMLS 71 C0162375 C4049867

Summaries for Giant Cell Reparative Granuloma

MalaCards based summary : Giant Cell Reparative Granuloma, also known as central giant cell granuloma, is related to hyperparathyroidism and aneurysmal bone cysts, and has symptoms including pain An important gene associated with Giant Cell Reparative Granuloma is SH3BP2 (SH3 Domain Binding Protein 2), and among its related pathways/superpathways are Presynaptic function of Kainate receptors and Osteoclast differentiation. The drugs Salmon calcitonin and Denosumab have been mentioned in the context of this disorder. Affiliated tissues include bone, salivary gland and testes, and related phenotypes are hematopoietic system and immune system

Related Diseases for Giant Cell Reparative Granuloma

Diseases related to Giant Cell Reparative Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 hyperparathyroidism 30.6 TNFSF11 PTH CALCA
2 aneurysmal bone cysts 30.5 USP6 TNFSF11 TNFRSF11A CALCA
3 epulis 30.5 SERPINA3 CD68
4 root resorption 30.4 TNFSF11 TNFRSF11A CALCR CALCA
5 osteitis fibrosa 30.3 PTH CALCA
6 fibrous dysplasia 30.2 TNFSF11 TNFRSF11A SH3BP2 CALCA
7 exophthalmos 30.0 NF1 CD68
8 primary hyperparathyroidism 29.9 TNFSF11 PTH CALCA
9 chondroblastoma 29.9 USP6 TNFSF11 SERPINA3
10 cherubism 29.9 USP6 TNFSF11 SH3BP2 SERPINA3 CALCA
11 mammary paget's disease 29.8 TNFSF11 TNFRSF11A PTH CALCA
12 osteomalacia 29.6 TNFSF11 PTH CALCA
13 paget's disease of bone 29.4 TNFSF11 TNFRSF11A PTH CALCA
14 fibroma 29.4 USP6 SERPINA3 NF1 CD68
15 benign giant cell tumor 29.3 USP6 TNFSF11 TNFRSF11A SERPINA3 CD68 CALCA
16 ossifying fibroma 29.2 USP6 SH3BP2 SERPINA3 PTH NF1
17 bone disease 29.1 TNFSF11 TNFRSF11A SERPINA3 PTH CALCA
18 bone resorption disease 28.7 TNFSF11 TNFRSF11A SERPINA3 PTH CALCR CALCA
19 bone giant cell tumor 27.0 USP6 TNFSF11 TNFRSF11A SH3BP2 SERPINA3 PTH
20 pancreatic somatostatinoma 10.3 NF1 CALCA
21 somatostatinoma 10.3 NF1 CALCA
22 peripheral nerve schwannoma 10.3 SERPINA3 NF1
23 perianal hematoma 10.3 NF1 CALCA
24 cerebellar astrocytoma 10.3 SERPINA3 NF1
25 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
26 chondroma 10.3
27 enchondroma 10.3
28 autonomic nervous system benign neoplasm 10.3 NF1 CALCA
29 peripheral nervous system benign neoplasm 10.3 NF1 CALCA
30 chronic pyelonephritis 10.3 SERPINA3 CALCA
31 substernal goiter 10.2 PTH CALCA
32 atypical depressive disorder 10.2 SERPINA3 NR3C1
33 steroid-induced glaucoma 10.2 SERPINA3 NR3C1
34 multiple endocrine neoplasia, type iib 10.2 NF1 CALCA
35 persistent generalized lymphadenopathy 10.2 SERPINA3 NF1
36 otitis media 10.2
37 osteogenic sarcoma 10.2
38 hypercalcemia, infantile, 1 10.2 PTH CALCA
39 hypervitaminosis d 10.2 PTH CALCA
40 polyarticular onset juvenile idiopathic arthritis 10.2 TNFSF11 TNFRSF11A
41 endemic goiter 10.2 PTH CALCA
42 hemophilic arthropathy 10.2 TNFSF11 TNFRSF11A
43 nontoxic goiter 10.2 PTH CALCA
44 conventional central osteosarcoma 10.2 USP6 SERPINA3
45 pleomorphic xanthoastrocytoma 10.1 SERPINA3 NF1
46 disseminated chorioretinitis 10.1 TNFSF11 TNFRSF11A
47 verruciform xanthoma of skin 10.1 SERPINA3 CD68
48 congenital epulis 10.1 SERPINA3 CD68
49 graves disease 1 10.1 PTH CALCA
50 xanthogranulomatous pyelonephritis 10.1 SERPINA3 CD68

Graphical network of the top 20 diseases related to Giant Cell Reparative Granuloma:



Diseases related to Giant Cell Reparative Granuloma

Symptoms & Phenotypes for Giant Cell Reparative Granuloma

UMLS symptoms related to Giant Cell Reparative Granuloma:


pain

MGI Mouse Phenotypes related to Giant Cell Reparative Granuloma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CALCR CALCRL CD68 NF1 NR3C1 PTH
2 immune system MP:0005387 9.91 CALCR CALCRL CD68 NF1 NR3C1 PTH
3 integument MP:0010771 9.7 CALCRL NF1 NR3C1 SERPINA3 SH3BP2 TNFRSF11A
4 limbs/digits/tail MP:0005371 9.43 CALCR NF1 PTH SH3BP2 TNFRSF11A TNFSF11
5 skeleton MP:0005390 9.23 CALCR CD68 NF1 NR3C1 PTH SH3BP2

Drugs & Therapeutics for Giant Cell Reparative Granuloma

Drugs for Giant Cell Reparative Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salmon calcitonin Approved, Investigational Phase 2 47931-85-1 16129616
2
Denosumab Approved Phase 2 615258-40-7
3
Calcitonin gene-related peptide Investigational Phase 2 83652-28-2
4 Hormones Phase 2
5 Vasodilator Agents Phase 2
6 Calcium, Dietary Phase 2
7 calcitonin Phase 2
8 Katacalcin Phase 2
9
Calcium Nutraceutical Phase 2 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Aggressive Central Giant Cell Granuloma Completed NCT02358304 Phase 2 nasal spray calcitonin;Placebo
2 An Open-label, Multi-center, Phase 2 Study of Denosumab in Subjects With Giant Cell Rich Tumors of Bone Recruiting NCT03605199 Phase 2 Denosumab

Search NIH Clinical Center for Giant Cell Reparative Granuloma

Cochrane evidence based reviews: granuloma, giant cell

Genetic Tests for Giant Cell Reparative Granuloma

Anatomical Context for Giant Cell Reparative Granuloma

MalaCards organs/tissues related to Giant Cell Reparative Granuloma:

40
Bone, Salivary Gland, Testes, Endothelial, Lymph Node, Heart, Smooth Muscle

Publications for Giant Cell Reparative Granuloma

Articles related to Giant Cell Reparative Granuloma:

(show top 50) (show all 631)
# Title Authors PMID Year
1
Interventions for central giant cell granuloma (CGCG) of the jaws. 54 61
19821413 2009
2
Central giant cell lesion of the jaw: nonsurgical treatment with calcitonin nasal spray. 61 54
19464656 2009
3
Calcitonin: a non-invasive giant cells therapy. 54 61
18466982 2008
4
DNA analysis of the SH3BP2 gene in patients with aggressive central giant cell granuloma. 54 61
16713042 2007
5
Calcitonin nasal spray for treatment of central giant cell granuloma: clinical, radiological, and histological findings and immunohistochemical expression of calcitonin and glucocorticoid receptors. 54 61
17630098 2007
6
Giant cell reparative granuloma of the temporal bone treated with calcitonin. 61 54
16788413 2006
7
Calcitonin therapy in central giant cell granuloma of the jaw: a randomized double-blind placebo-controlled study. 61 54
16829031 2006
8
Limited regression of central giant cell granuloma by interferon alpha after failed calcitonin therapy: a report of 2 cases. 54 61
16584870 2006
9
Immunohistochemical expression of glucocorticoid and calcitonin receptors as a tool for selecting therapeutic approach in central giant cell granuloma of the jawbones. 61 54
16580179 2006
10
Immunohistochemical expression of RANK, GRalpha and CTR in central giant cell granuloma of the jaws. 61 54
15878752 2005
11
Calcitonin therapy for central giant cell granuloma. 61 54
12796868 2003
12
Neurofibromatosis 1: a novel NF1 mutation in an 11-year-old girl with a giant cell granuloma. 54 61
12822827 2003
13
Treatment of central giant cell granuloma of the jaw with calcitonin. 61 54
10535540 1999
14
[Calcitonin therapy in large or recurrent central giant cell granulomas of the lower jaw]. 61 54
9132608 1997
15
Immunohistochemical expression of stem cell markers OCT-4 and SOX-2 in giant cell tumor, central giant cell granuloma, and peripheral giant cell granuloma. 61
32493681 2020
16
Central Giant Cell Granuloma Treated with Intralesional Corticosteroid Injections and Bisphosphonates: A Long-Term Follow-Up Case Study. 61
31297738 2020
17
Central giant cell granuloma: A clinicopathological and immunohistochemical study of macrophages, blood vessels, lymphatic vessels and regulatory proteins. 61
32339965 2020
18
Cervical-Thoracic Epidural Giant Cell Reparative Granuloma: Case Report and Review of the Literature. 61
31931251 2020
19
Pathologic evaluation of the solid variant of aneurysmal bone cysts with USP6 rearrangement with an emphasis on the frequent diagnostic pitfalls. 61
32342641 2020
20
Soft Tissue Special Issue: Giant Cell-Rich Lesions of the Head and Neck Region. 61
31950466 2020
21
Incidental findings in a consecutive series of digital panoramic radiographs. 61
32206621 2020
22
Giant cell reparative granuloma of the mandible with an aggressive radiological appearance. 61
31850797 2020
23
Commentary to: Giant cell reparative granuloma of the scapula: report of a case and literature review. 61
31712837 2020
24
Response to a letter to the editor concerning "Giant Cell Reparative Granuloma of the Scapula: report of a case and literature review". 61
31642972 2020
25
Central giant cell granuloma of the mandibular condyle: A rare case and a literature review. 61
31909260 2020
26
Giant Cell Lesions of the Jaws:A Review and Comparative Histopathological Study. 61
32030708 2020
27
Maxillary Giant Cell Granuloma: A Long-Term Follow-Up. 61
31012347 2020
28
A Comparative Analysis of p63 Expression in Giant Cell Tumour (GCT), Central Giant Cell Granuloma (CGCG) and Peripheral Giant Cell Granuloma (PGCG). 61
31873936 2019
29
Explanation for different behavior of peripheral and central giant cell granuloma by CD44 and CD34 immunostaining. 61
31433127 2019
30
Use of Denosumab in Children With Osteoclast Bone Dysplasias: Report of Three Cases. 61
31687646 2019
31
Potential role of Hedgehog signaling pathway and myofibroblastic differentiation in central giant cell granuloma-A preliminary study. 61
31408546 2019
32
Aggressive type of central giant cell granuloma in a woman on hormone replacement therapy: a histopathological insight. 61
31413060 2019
33
[Unique Experience of Cherubism Targeted Therapy]. 61
31747153 2019
34
[Giant cell reparative granuloma of the temporal bone: A case report]. 61
31570683 2019
35
Giant cell reparative granuloma of the scapula: report of a case and literature review. 61
30607456 2019
36
Maxillary Giant Cell Granuloma: A Long-Term Follow-Up. 61
31064243 2019
37
Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone. 61
30844887 2019
38
An aggressive central giant cell granuloma in a pediatric patient: case report and review of literature. 61
31319877 2019
39
Radiotherapy for recurrent central Giant cell granuloma: a case report. 61
31324249 2019
40
Common conditions associated with displacement of the inferior alveolar nerve canal: A radiographic diagnostic aid. 61
31281784 2019
41
Diffuse Tenosynovial Giant Cell Tumor Around the Temporomandibular Joint: An Entity With Special Radiologic and Pathologic Features. 61
30796908 2019
42
Giant Cell Granulomas of Jaws: a Clinicopathologic Study. 61
31404210 2019
43
A comparative study of osteopontin and MMP-2 protein expression in peripheral and central giant cell granuloma of the jaw. 61
29339027 2019
44
Central giant cell granuloma - A case report. 61
30900672 2019
45
Case Report: rare hybrid lesion of a central giant cell granuloma within a juvenile ossifying fibroma. 61
31632653 2019
46
Regional Lymph Node Enlargement in Clinically Severe Cherubism. 61
31321387 2019
47
Foreign body reaction simulating mandibular osteosarcoma-Case report. 61
31203000 2019
48
Management of Central Giant Cell Granulomas of the Jaws: An Unusual Case Report with Critical Appraisal of Existing Literature. 61
31293928 2019
49
Evaluation of Cyclin D1 Expression in Aggressive and Nonaggressive Central Giant Cell Granuloma of the Jaws. 61
30680296 2018
50
Coordinated pediatric reconstruction and rehabilitation of maxillary central giant cell granuloma: A case report. 61
30243428 2018

Variations for Giant Cell Reparative Granuloma

Expression for Giant Cell Reparative Granuloma

Search GEO for disease gene expression data for Giant Cell Reparative Granuloma.

Pathways for Giant Cell Reparative Granuloma

GO Terms for Giant Cell Reparative Granuloma

Biological processes related to Giant Cell Reparative Granuloma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 calcium ion homeostasis GO:0055074 9.55 TNFSF11 PTH
2 negative regulation of osteoclast differentiation GO:0045671 9.54 NF1 CALCA
3 monocyte chemotaxis GO:0002548 9.54 TNFSF11 TNFRSF11A CALCA
4 bone resorption GO:0045453 9.52 TNFSF11 PTH
5 negative regulation of ossification GO:0030279 9.51 CALCR CALCA
6 positive regulation of bone resorption GO:0045780 9.49 TNFSF11 TNFRSF11A
7 mammary gland alveolus development GO:0060749 9.48 TNFSF11 TNFRSF11A
8 amylin receptor signaling pathway GO:0097647 9.46 CALCR CALCA
9 negative regulation of smooth muscle contraction GO:0045986 9.43 CALCRL CALCA
10 osteoclast differentiation GO:0030316 9.43 TNFSF11 TNFRSF11A CALCR
11 TNFSF11-mediated signaling pathway GO:0071847 9.4 TNFSF11 TNFRSF11A
12 calcitonin gene-related peptide receptor signaling pathway GO:1990408 9.32 CALCRL CALCA
13 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.16 TNFSF11 TNFRSF11A
14 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFSF11 TNFRSF11A
15 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 8.92 PTH CALCRL CALCR CALCA

Molecular functions related to Giant Cell Reparative Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcitonin gene-related peptide receptor activity GO:0001635 8.96 CALCRL CALCR
2 calcitonin receptor activity GO:0004948 8.62 CALCRL CALCR

Sources for Giant Cell Reparative Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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