MCID: GNT008
MIFTS: 49

Giant Cell Tumor

Categories: Cancer diseases

Aliases & Classifications for Giant Cell Tumor

MalaCards integrated aliases for Giant Cell Tumor:

Name: Giant Cell Tumor 12 15
Giant Cell Tumors 12 55 44 73
Tumor of the Giant Cell 12
Giant Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:200
MeSH 44 D005870
NCIt 50 C3055 C7069
UMLS 73 C0017525

Summaries for Giant Cell Tumor

MalaCards based summary : Giant Cell Tumor, also known as giant cell tumors, is related to tenosynovial giant cell tumor and malignant giant cell tumor. An important gene associated with Giant Cell Tumor is ZNF687 (Zinc Finger Protein 687), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Xgeva and Denosumab have been mentioned in the context of this disorder. Affiliated tissues include bone, pancreas and lung, and related phenotypes are limbs/digits/tail and muscle

Related Diseases for Giant Cell Tumor

Diseases in the Giant Cell Tumor family:

Malignant Giant Cell Tumor

Diseases related to Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)
# Related Disease Score Top Affiliating Genes
1 tenosynovial giant cell tumor 34.0 CSF1 SERPINA3
2 malignant giant cell tumor 33.9 ACTC1 H3F3A
3 malignant giant cell tumor of soft parts 33.8 ACTC1 PTPRC
4 bone giant cell tumor 33.7 CALCA CTSK H3F3A TNFSF11 VIM
5 pigmented villonodular synovitis 32.9 CSF1 MMP9 PTPRC TNFSF11
6 nodular tenosynovitis 32.8 PTPRC SERPINA3
7 villonodular synovitis 30.9 MMP9 TNFSF11 VIM
8 aneurysmal bone cysts 30.5 CALCA TNFRSF11A TNFSF11
9 epulis 30.3 DES VIM
10 mucinous cystadenocarcinoma 30.2 MUC1 PTPRC VIM
11 giant cell reparative granuloma 30.2 CALCA TNFRSF11A
12 fibrosarcoma 29.9 DES MMP9 VIM
13 leiomyosarcoma 29.8 ACTC1 DES VIM
14 hyperparathyroidism 29.8 BGLAP CALCA TNFRSF11B
15 spindle cell sarcoma 29.7 ACTC1 DES MUC1 VIM
16 chordoma 29.7 CTSK DES MUC1 VIM
17 paget's disease of bone 29.7 BGLAP CALCA CSF1 TNFRSF11A TNFRSF11B TNFSF11
18 fibrous histiocytoma 29.7 ACTC1 DES SERPINA3 VIM
19 pleomorphic adenoma 29.6 ACTC1 MUC1 VIM
20 arthritis 29.6 CSF1 MMP9 TNFRSF11A TNFSF11
21 sarcoma, synovial 29.6 DES MUC1 VIM
22 chondromyxoid fibroma 29.6 ACTC1 DES VIM
23 osteonecrosis 29.5 BGLAP TNFRSF11B TNFSF11
24 osteitis fibrosa 29.5 BGLAP CALCA
25 rheumatoid arthritis 29.5 CSF1 CTSK MMP9 TNFRSF11A TNFRSF11B TNFSF11
26 dermatofibrosarcoma protuberans 29.4 ACTC1 DES SERPINA3 VIM
27 bone resorption disease 29.4 BGLAP CALCA CTSK TNFRSF11A TNFRSF11B TNFSF11
28 malignant fibroxanthoma 29.3 ACTC1 DES MUC1 PTPRC SERPINA3 VIM
29 bone inflammation disease 29.3 BGLAP CTSK TNFRSF11B TNFSF11
30 bone disease 28.5 BGLAP CALCA CSF1 CTSK TNFRSF11A TNFRSF11B
31 malignant giant cell tumor of the tendon sheath 12.3
32 osteoclast-like giant cell neoplasm of the pancreas 12.2
33 osteoclastic giant cell tumor of pancreas 12.2
34 bone giant cell sarcoma 11.9
35 cherubism 11.5
36 paget disease of bone 6 11.2
37 synovitis 10.4
38 degos 'en cocarde' erythrokeratoderma 10.3
39 breast leiomyosarcoma 10.3 TNFRSF11A TNFSF11
40 mandibular cancer 10.2 CSF1 TNFSF11
41 retroperitoneal fibrosis 10.2 PTPRC VIM
42 sarcoma 10.2
43 kummell's disease 10.2 TNFRSF11B TNFSF11
44 gingival hypertrophy 10.2 MMP9 VIM
45 periodontitis, chronic 10.2 TNFRSF11B TNFSF11
46 lymphangiectasis 10.2 ACTC1 VIM
47 chronic apical periodontitis 10.2 TNFRSF11B TNFSF11
48 malignant peritoneal mesothelioma 10.2 MUC1 VIM
49 glomangiomyoma 10.2 ACTC1 VIM
50 papillary tumor of the pineal region 10.2 MUC1 VIM

Graphical network of the top 20 diseases related to Giant Cell Tumor:



Diseases related to Giant Cell Tumor

Symptoms & Phenotypes for Giant Cell Tumor

MGI Mouse Phenotypes related to Giant Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.63 CSF1 CTSK MMP9 TNFRSF11A TNFRSF11B TNFSF11
2 muscle MP:0005369 9.5 ACTC1 ADAM12 CSF1 DES MMP9 TNFSF11
3 respiratory system MP:0005388 9.17 CSF1 CTSK MMP9 PTPRC TNFRSF11A TNFSF11

Drugs & Therapeutics for Giant Cell Tumor

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Xgeva 18 49 DENOSUMAB Amgen June 2013/ November 2010

Drugs for Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1 615258-40-7
2 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1
3 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
4 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
5 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2
6 Immunologic Factors Phase 4,Phase 2,Early Phase 1
7 Immunoglobulin G Phase 4
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
9
Ethanol Approved Phase 3 64-17-5 702
10
Phenol Approved, Experimental Phase 3 108-95-2 996
11
Zoledronic acid Approved Phase 3,Phase 1,Phase 2 118072-93-8 68740
12 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
13 Cola Phase 3,Early Phase 1
14 Central Nervous System Depressants Phase 3,Phase 1
15 Adjuvants, Anesthesia Phase 3,Phase 1
16 Liver Extracts Phase 3,Early Phase 1
17 Anesthetics, Intravenous Phase 3,Phase 1
18 Analgesics, Opioid Phase 3
19 Peripheral Nervous System Agents Phase 3
20 Anesthetics, General Phase 3,Phase 1
21 Analgesics Phase 3
22 Narcotics Phase 3
23 Anesthetics Phase 3,Phase 1
24 Diphosphonates Phase 3,Phase 2
25 Polymethyl Methacrylate Phase 3
26
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
27
Nivolumab Approved Phase 2 946414-94-4
28
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
29 Micronutrients Phase 2
30 Calciferol Phase 2
31 Trace Elements Phase 2
32 Calcium, Dietary Phase 2
33 Vitamins Phase 2
34 Grapefruit Seed Extract Phase 2
35 Protein Kinase Inhibitors Phase 2
36 Pharmaceutical Solutions Phase 2,Phase 1
37
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
38
Tolbutamide Approved, Investigational Phase 1 64-77-7 5505
39
Midazolam Approved, Illicit Phase 1 59467-70-8 4192
40 Antineoplastic Agents, Phytogenic Phase 1
41 Albumin-Bound Paclitaxel Phase 1
42 Antimitotic Agents Phase 1
43 Hypnotics and Sedatives Phase 1
44 Anti-Anxiety Agents Phase 1
45 Hypoglycemic Agents Phase 1
46 GABA Agents Phase 1
47 Neurotransmitter Agents Phase 1
48 Tranquilizing Agents Phase 1
49 Psychotropic Drugs Phase 1
50 GABA Modulators Phase 1

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004 Active, not recruiting NCT03301857 Phase 4 Denosumab (Cohort A)
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Characteristics and Mechanism of Denosumab-treated Giant Cell Tumor of Bone Recruiting NCT03259152 Phase 3 Denosumab
4 Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone Recruiting NCT03295981 Phase 3 Zoledronic Acid
5 Phase 3 Study of Pexidartinib for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS) Active, not recruiting NCT02371369 Phase 3 Pexidartinib;Placebo
6 Safety and Efficacy Study of Denosumab in Patients With Recurrent or Unresectable Giant Cell Tumor of Bone Completed NCT00396279 Phase 2
7 Study of Denosumab in Subjects With Giant Cell Tumor of Bone Completed NCT00680992 Phase 2 Denosumab
8 Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT) Completed NCT01261429 Phase 2 Tasigna
9 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
10 Trial of Dasatinib in Advanced Sarcomas Completed NCT00464620 Phase 2 Dasatinib
11 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
12 Study of Cabiralizumab in Patients With Pigmented Villonodular Synovitis / Diffuse Type Tenosynovial Giant Cell Tumor Active, not recruiting NCT02471716 Phase 1, Phase 2
13 Nilotinib in Patients With Relapsed or Metastatic Pigmented Villonodular Synovitis/Tenosynovial Giant Cell Tumor/Diffuse-Type Giant Cell Tumor Active, not recruiting NCT01207492 Phase 2 nilotinib
14 MCS110 in Patients With Pigmented Villonodular Synovitis (PVNS) Active, not recruiting NCT01643850 Phase 2 MCS110;Placebo;MCS110;Placebo
15 Denosumab Treatment for Fibrous Dysplasia Enrolling by invitation NCT03571191 Phase 2 Denosumab;Denosumab;Denosumab
16 Reduced Dose-density of Denosumab for Unresectable GCTB Not yet recruiting NCT03620149 Phase 2 Denosumab 120 MG/1.7 ML Subcutaneous Solution [XGEVA]
17 Study of the Effect of Zoledronate on Local Recurrence After Surgical Treatment of Giant Cell Tumors of Bone Zométa Terminated NCT01564121 Phase 1, Phase 2 acid Zoledronic
18 Adjuvant Zoledronic Acid in High Risk Giant Cell Tumour of Bone (GCT) Terminated NCT00889590 Phase 2 Zoledronic acid
19 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Completed NCT01494688 Phase 1 Paclitaxel;RO5509554
20 Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics) Active, not recruiting NCT03291288 Phase 1 Tolbutamide;Midazolam;Pexidartinib
21 A Study of PLX73086 in Advanced Solid Tumors and Locally Advanced or Refractory Tenosynovial Giant Cell Tumor Terminated NCT02673736 Phase 1 PLX73086
22 Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors Terminated NCT01804530 Phase 1 PLX7486 TsOH
23 Giant Cell Tumor of the Extremities Treated With Surgery and/or Medical Treatment Completed NCT02996734
24 Tenosynovial Giant Cell Tumors (TGCT) Observational Platform Project Recruiting NCT02948088
25 Evaluation of the Effectiveness of Surgical Treatment of Villo-nodular Synovitis of the Hip in Children Recruiting NCT03507933
26 Safety and Efficacy of Post-operative Denosumab Strategy for Giant Cell Tumor of Bone Treatment in China Not yet recruiting NCT03358212 Denosumab
27 Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer Terminated NCT00499733 Early Phase 1 cyclophosphamide

Search NIH Clinical Center for Giant Cell Tumor

Cochrane evidence based reviews: giant cell tumors

Genetic Tests for Giant Cell Tumor

Anatomical Context for Giant Cell Tumor

MalaCards organs/tissues related to Giant Cell Tumor:

41
Bone, Pancreas, Lung, Liver, Thyroid, Skin, Spinal Cord

Publications for Giant Cell Tumor

Articles related to Giant Cell Tumor:

(show top 50) (show all 1878)
# Title Authors Year
1
Giant Cell Tumor of the Temporal Bone and Skull Base: A Case Report. ( 29764791 )
2018
2
Osteonecrosis of the Jaw and Rebound Hypercalcemia in Young People Treated With Denosumab for Giant Cell Tumor of Bone. ( 29211870 )
2018
3
Expression of MMP-2 and TIMP-3 with incidence and prognosis of giant-cell tumor of the bone. ( 29963137 )
2018
4
Giant Cell Tumor of the Ribs and Aneurysmal Bone Cyst Presenting with Hemothorax in a Child: Erratum. ( 29738344 )
2018
5
Retrospective investigation of "paint brush borders" sign in association with local recurrence of giant cell tumor of bone after intralesional curettage. ( 29255669 )
2018
6
First Case Report of a Huge Giant Cell Tumor of Soft Tissue Originating from the Retroperitoneum. ( 29867073 )
2018
7
Mid- to long-term clinical outcome of giant cell tumor of bone treated with calcium phosphate cement following thorough curettage and phenolization. ( 29315595 )
2018
8
Therapeutic benefits of neoadjuvant and post-operative denosumab on sacral giant cell tumor: a retrospective cohort study of 30 cases. ( 29745092 )
2018
9
Bone combined cement grafting in giant cell tumor around the knee reduces mechanical failure. ( 29700587 )
2018
10
Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints. ( 29637236 )
2018
11
The Values of Receptor Activator Nuclear Kappa-B Ligand Expression in Stage III Giant Cell Tumor of the Bone. ( 29416167 )
2018
12
Extra-articular tenosynovial giant cell tumor of diffuse type in the temporal area with brain parenchymal invasion: a case report. ( 29334779 )
2018
13
Primary Pulmonary Giant Cell Tumor. ( 29909079 )
2018
14
Giant Cell Tumor of Bone in Patients 55 Years and Older: A Study of 34 Patients. ( 29425276 )
2018
15
Retrospective Analysis of Giant Cell Tumor Lower End Radius Treated with<i>En bloc</i>Excision and Translocation of Ulna. ( 29416164 )
2018
16
Norcantharidin modulates the miR-30a/Metadherin/AKT signaling axis to suppress proliferation and metastasis of stromal tumor cells in giant cell tumor of bone. ( 29710674 )
2018
17
An extremely rare case of primary malignancy in giant cell tumor of bone, arising in the right femur and harboring H3F3A mutation. ( 29970305 )
2018
18
Detection of H3F3A p.G35W and p.G35R in giant cell tumor of bone by Allele Specific Locked Nucleic Acid quantitative PCR (ASLNAqPCR). ( 29254795 )
2018
19
Multiple Giant Cell Tumor of Tendon Sheath Involving Both Flexor and Extensor Tendons in a Single Digit: A Case Report and Review of the Literatures. ( 29734904 )
2018
20
Successful treatment of a diffuse type tenosynovial giant cell tumor in the thoracic spine mimicking spinal metastasis by frozen recapping laminoplasty in a patient with thyroid cancer. ( 29663145 )
2018
21
Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy. ( 29757500 )
2018
22
Uncemented three-dimensional-printed prosthetic replacement for giant cell tumor of distal radius: a new design of prosthesis and surgical techniques. ( 29445303 )
2018
23
Denosumab-Treated Giant Cell Tumor of the Bone Mimicking Low-Grade Central Osteosarcoma. ( 29429326 )
2018
24
Response evaluation of giant-cell tumor of bone treated by denosumab: Histogram and texture analysis of CT images. ( 29429890 )
2018
25
Osteoscopic Surgery of Giant Cell Tumor of Bone for Preservation of Proximal Fibula. ( 29715130 )
2018
26
Vascularized Iliac Bone Lining in Downgraded Treatment of Campanacci Grade III Giant Cell Tumor of the Distal Radius. ( 29734913 )
2018
27
Giant Cell Tumor of the Lateral Skull Base: Diagnostic and Management Options. ( 29845001 )
2018
28
Osteolytic lesions (brown tumors) of primary hyperparathyroidism misdiagnosed as multifocal giant cell tumor of the distal ulna and radius: a case report. ( 29936913 )
2018
29
Pycnodysostosis: Novel Variants in<i>CTSK</i>and Occurrence of Giant Cell Tumor. ( 29441215 )
2018
30
Tuberculosis of knee joint mimicking giant cell tumor - A case report. ( 29933871 )
2018
31
Recurrence of Giant Cell Tumor of The Larynx. ( 29419584 )
2018
32
Giant cell tumor of bone: updated molecular pathogenesis and tumor biology. ( 29944971 )
2018
33
Giant cell tumor at the clivus: Not an area 51. ( 29766962 )
2018
34
Prognosis of metastatic giant cell tumor of bone in the pre-denosumab era. A systematic review and a meta-analysis. ( 29741702 )
2018
35
A Triple-Classification Radiomics Model for the Differentiation of Primary Chordoma, Giant Cell Tumor, and Metastatic Tumor of Sacrum Based on T2-Weighted and Contrast-Enhanced T1-Weighted MRI. ( 30430686 )
2018
36
A Rare Case Report of Giant Cell Tumor of the Sphenoid Bone in a Patient Who Developed "Erythema Multiforme Associated with Phenytoin and Cranial Radiation Therapy Syndrome". ( 30283572 )
2018
37
Recommencement of Denosumab for Unresectable Giant Cell Tumor of the Cervical Spine: A Case Report. ( 29016442 )
2018
38
Treatment of giant cell tumor of distal radius with limited soft tissue invasion: Curettage and cementing versus wide excision. ( 29110910 )
2018
39
Giant cell tumor of temporomandibular joint presenting as a parotid tumor: Challenges in the accurate subclassification of giant cell tumors in an unusual location. ( 29193882 )
2018
40
Magnetic resonance feature of "paintbrush borders" sign as a novel way to predict recurrence of giant cell tumor of bone after curettage: a pilot study. ( 29239274 )
2018
41
Resection of a Giant-Cell Tumor of the Proximal Aspect of the Radius with Osteoarticular Allograft Reconstruction: A Case Report. ( 29443818 )
2018
42
ALCAM+ stromal cells: role in giant cell tumor of bone progression. ( 29463803 )
2018
43
Expression of H3.3 G34W Distinguishes Giant Cell Tumor of Bone From Its Major Giant Cell-containing Bone and Soft Tissue Mimics, in Particular Aneurysmal Bone Cyst and Giant Cell Tumor of Soft Tissue. ( 29489506 )
2018
44
En-bloc Resection of a Giant Cell Tumor Causing Cervical Vertebral Collapse. ( 29492149 )
2018
45
Primary thoracic giant cell tumor of bone sensitive to steroids. ( 29502130 )
2018
46
Third-Ray and Capitate Resection with Limited Midcarpal Fusion for Recurrent Giant Cell Tumor: A Case Report. ( 29538093 )
2018
47
Giant-cell tumor of the rib cage extending to the spine : Case report. ( 29556745 )
2018
48
Denosumab May Increase the Risk of Local Recurrence in Patients with Giant-Cell Tumor of Bone Treated with Curettage. ( 29557866 )
2018
49
Giant Cell Tumor of Bone Presenting as Left Posteromedial Chest Wall Tumor. ( 29577929 )
2018
50
The Most Appropriate Reconstruction Method Following Giant Cell Tumor Curettage: A Biomechanical Approach. ( 29600259 )
2018

Variations for Giant Cell Tumor

Expression for Giant Cell Tumor

Search GEO for disease gene expression data for Giant Cell Tumor.

Pathways for Giant Cell Tumor

Pathways related to Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 CSF1 CTSK MMP9 MUC1 PTPRC SERPINA3
2
Show member pathways
13.06 CSF1 MMP9 MUC1 TNFRSF11A TNFRSF11B TNFSF11
3
Show member pathways
12.63 ADAM12 MMP9 PTPRC TNFRSF11A TNFRSF11B TNFSF11
4 12.28 ACTC1 DES MUC1 VIM
5
Show member pathways
12.16 CTSK TNFRSF11A TNFRSF11B TNFSF11
6 11.76 MMP9 MUC1 VIM
7 11.66 CSF1 CTSK TNFRSF11A TNFRSF11B TNFSF11
8
Show member pathways
11.65 ADAM12 CTSK MMP9
9 11.58 CSF1 CTSK TNFRSF11A TNFSF11
10 11.47 ACTC1 DES VIM
11 10.67 BGLAP CALCA TNFRSF11A TNFRSF11B TNFSF11
12 10.58 BGLAP TNFRSF11B TNFSF11
13 10.46 CTSK TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Giant Cell Tumor

Cellular components related to Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 ACTC1 DES H3F3A MMP9 MUC1 PTPRC
2 extracellular space GO:0005615 9.65 ACTC1 BGLAP CALCA CSF1 CTSK MMP9
3 extracellular region GO:0005576 9.36 ADAM12 BGLAP CALCA CSF1 CTSK H3F3A

Biological processes related to Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-mediated signaling pathway GO:0033209 9.67 TNFRSF11A TNFRSF11B TNFSF11
2 monocyte chemotaxis GO:0002548 9.65 CALCA TNFRSF11A TNFSF11
3 cytokine-mediated signaling pathway GO:0019221 9.65 CSF1 MMP9 MUC1 TNFSF11 VIM
4 embryo implantation GO:0007566 9.61 CALCA H3F3A MMP9
5 positive regulation of osteoclast differentiation GO:0045672 9.59 CSF1 TNFSF11
6 intermediate filament organization GO:0045109 9.58 DES VIM
7 positive regulation of bone resorption GO:0045780 9.58 TNFRSF11A TNFSF11
8 muscle filament sliding GO:0030049 9.58 ACTC1 DES VIM
9 macrophage differentiation GO:0030225 9.57 CSF1 MMP9
10 mammary gland alveolus development GO:0060749 9.56 TNFRSF11A TNFSF11
11 regulation of osteoclast differentiation GO:0045670 9.55 BGLAP TNFSF11
12 positive regulation of macrophage differentiation GO:0045651 9.54 CALCA CSF1
13 negative regulation of bone resorption GO:0045779 9.52 CALCA TNFRSF11B
14 response to inorganic substance GO:0010035 9.51 BGLAP TNFRSF11B
15 osteoclast differentiation GO:0030316 9.5 CSF1 TNFRSF11A TNFSF11
16 TNFSF11-mediated signaling pathway GO:0071847 9.46 TNFRSF11A TNFSF11
17 osteoclast proliferation GO:0002158 9.37 CSF1 TNFSF11
18 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.16 TNFRSF11A TNFSF11
19 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFRSF11A TNFSF11
20 ossification GO:0001503 8.92 BGLAP MMP9 TNFRSF11A TNFSF11

Sources for Giant Cell Tumor

3 CDC
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10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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44 MeSH
45 MESH via Orphanet
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
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71 TGDB
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