MCID: GNT005
MIFTS: 34

Giant Hemangioma

Categories: Blood diseases

Aliases & Classifications for Giant Hemangioma

MalaCards integrated aliases for Giant Hemangioma:

Name: Giant Hemangioma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5774
NCIt 51 C27777
UMLS 74 C1333817

Summaries for Giant Hemangioma

MalaCards based summary : Giant Hemangioma is related to hemangioma of liver and purpura. An important gene associated with Giant Hemangioma is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). Affiliated tissues include liver, spleen and tongue, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Giant Hemangioma

Diseases related to Giant Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 hemangioma of liver 30.3 F2 IFNA2
2 purpura 29.7 F2 F3 SERPINC1
3 thrombosis 29.5 F2 F3 SERPINC1
4 budd-chiari syndrome 29.4 F2 F3 SERPINC1
5 disseminated intravascular coagulation 29.3 F2 F3 SERPINC1 SERPINF2
6 hemangioma 10.7
7 thrombocytopenia 10.3
8 platelet aggregation, spontaneous 10.3 SERPINC1 SERPINF2
9 cold urticaria 10.3 SERPINC1 SERPINF2
10 heparin-induced thrombocytopenia 10.2 F3 SERPINC1
11 endocarditis 10.2 F2 SERPINC1
12 angina pectoris 10.2 SERPINC1 SERPINF2
13 hemangioma-thrombocytopenia syndrome 10.2
14 retinal artery occlusion 10.2 F2 SERPINC1
15 factor xii deficiency 10.2 F3 SERPINC1
16 acute poststreptococcal glomerulonephritis 10.2 PLG SERPINF2
17 spinal cord infarction 10.2 F2 SERPINC1
18 coronary thrombosis 10.2 F3 SERPINC1
19 prothrombin deficiency, congenital 10.2 F2 SERPINC1
20 acute cor pulmonale 10.2 PLG SERPINF2
21 pulmonary immaturity 10.2 F3 SERPINC1
22 ischemic colitis 10.2 F2 SERPINC1
23 factor xiii deficiency 10.2 F3 SERPINF2
24 acute pulmonary heart disease 10.2 PLG SERPINF2
25 subendocardial myocardial infarction 10.2 F2 SERPINC1
26 sneddon syndrome 10.2 F2 SERPINC1
27 osteonecrosis 10.2 F2 SERPINC1
28 esophageal varix 10.1 F2 SERPINC1
29 antithrombin iii deficiency 10.1 F2 SERPINC1
30 post-thrombotic syndrome 10.1 F2 SERPINC1
31 conjugate gaze palsy 10.1 F3 PLG
32 hypersplenism 10.1 F2 SERPINC1
33 von willebrand disease, type 3 10.1 DLL1 F3
34 central retinal vein occlusion 10.1 F2 SERPINC1
35 retinal vein occlusion 10.1 F2 SERPINC1
36 von willebrand disease, type 2 10.1 DLL1 F3
37 portal vein thrombosis 10.1 F2 SERPINC1
38 dysbaric osteonecrosis 10.1 F3 PLG
39 vertebral artery occlusion 10.1 F3 PLG
40 afibrinogenemia 10.1 F2 F3
41 conjunctival disease 10.1 IFNA2 PLG
42 dysfibrinogenemia 10.1 F2 SERPINC1
43 hepatitis d 10.1 F2 IFNA2
44 lemierre's syndrome 10.1 F3 PLG
45 hemophilia 10.1 F2 F3
46 pyoderma 10.1 F3 IFNA2
47 prothrombin deficiency 10.1 F2 F3
48 cerebral sinovenous thrombosis 10.1 F2 F3
49 qualitative platelet defect 10.1 F2 F3
50 placental abruption 10.1 F2 SERPINC1

Graphical network of the top 20 diseases related to Giant Hemangioma:



Diseases related to Giant Hemangioma

Symptoms & Phenotypes for Giant Hemangioma

MGI Mouse Phenotypes related to Giant Hemangioma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 DLL1 F2 F3 PLG SERPINC1 TGFB1
2 hematopoietic system MP:0005397 9.73 DLL1 F2 F3 PLG SERPINC1 TGFB1
3 embryo MP:0005380 9.72 DLL1 F2 F3 SERPINC1 TGFB1
4 homeostasis/metabolism MP:0005376 9.7 DLL1 F2 F3 PLG SERPINC1 SERPINF2
5 immune system MP:0005387 9.43 DLL1 F2 F3 PLG SERPINC1 TGFB1
6 nervous system MP:0003631 9.1 DLL1 F2 F3 PLG SERPINC1 TGFB1

Drugs & Therapeutics for Giant Hemangioma

Search Clinical Trials , NIH Clinical Center for Giant Hemangioma

Genetic Tests for Giant Hemangioma

Anatomical Context for Giant Hemangioma

MalaCards organs/tissues related to Giant Hemangioma:

42
Liver, Spleen, Tongue, Testes, Heart, Spinal Cord, Placenta

Publications for Giant Hemangioma

Articles related to Giant Hemangioma:

(show top 50) (show all 90)
# Title Authors Year
1
Detection and monitoring of postinterventional success and complications of the liver using contrast-enhanced ultrasound (CEUS) - a case report after interventional treatment of a giant hemangioma. ( 30534665 )
2018
2
Pure laparoscopic right hepatectomy for giant hemangioma using anterior approach. ( 27620909 )
2017
3
Transoral ultrasonic surgery of pharyngolaryngeal giant hemangioma after ethylene-vinyl alcohol copolymer (Onyx) embolization. ( 28263419 )
2017
4
Giant hemangioma of anterior mediastinum mimicking bilateral pleural effusion. ( 29354184 )
2017
5
Resection of Giant Hemangioma of the Tongue Utilizing a Miniature Tourniquet Technique. ( 27391511 )
2016
6
Enucleation is Better for a Giant Hemangioma Proximal to the Hepatic Portal Vascular Structures. ( 27574349 )
2016
7
A rare case of intra and extra testicular varicocele caused by giant hemangioma of liver. ( 30005524 )
2016
8
Tumor size is not a criterion for resection during the management of giant hemangioma of the liver. ( 25923944 )
2015
9
Enucleation of a Giant Hemangioma of Liver: Old School Revisited. ( 26844001 )
2015
10
Giant hemangioma causing budd-Chiari syndrome. ( 25755587 )
2014
11
Feasibility of laparoscopic liver resection for giant hemangioma of greater than 6 cm in diameter. ( 26155263 )
2014
12
Successful liver resection in a giant hemangioma with intestinal obstruction after embolization. ( 23704832 )
2013
13
Giant hemangioma presenting as a scalp mass leading to a craniofacial deformity. ( 24431843 )
2013
14
Pre-operative arterial embolization of symptomatic giant hemangioma of the liver. ( 22691287 )
2012
15
Resection for progressively growing giant hemangioma of anterior abdominal wall. ( 22808765 )
2012
16
Airway management in a toddler with a giant hemangioma of the tongue. ( 23429176 )
2012
17
Hepatic angiomyolipoma with a giant hemangioma. ( 22041879 )
2011
18
Robotic right hepatectomy for giant hemangioma in a Jehovah's Witness. ( 20596878 )
2011
19
Management of giant hemangioma of the liver: resection versus observation. ( 20980175 )
2010
20
Laparoscopic partial splenectomy for giant hemangioma misdiagnosed as splenic cyst: a case report. ( 21180283 )
2010
21
Elective laparoscopic splenectomy for giant hemangioma: a case report. ( 19123949 )
2009
22
Solitary giant hemangioma of the humerus. ( 19968232 )
2009
23
Giant hemangioma of liver presenting as deep vein thrombosis of the lower limbs. ( 20083882 )
2009
24
Giant hemangioma. ( 20214002 )
2009
25
Adult Kasabach-Merritt Syndrome due to Hepatic Giant Hemangioma. ( 21103246 )
2009
26
Coagulation of a giant hemangioma in glans penis with holmium laser. ( 18097507 )
2008
27
Recurrent giant hemangioma causing severe respiratory distress. ( 17404885 )
2007
28
Giant hemangioma of the fetal neck, mimicking a teratoma. ( 16445525 )
2006
29
Adult giant hemangioma of the larynx: a case report. ( 16934420 )
2006
30
Antenatal sonographic and magnetic resonance images of a giant hemangioma of the fetal skull. ( 15846768 )
2005
31
Liver transplantation after backtable resection of giant hemangioma. ( 15973725 )
2005
32
Spontaneous rapid regression of a giant hemangioma mimicking a liver abscess. ( 16120941 )
2005
33
Giant hemangioma of the adrenal. ( 15562815 )
2004
34
Anesthesia during intralesional bare fiber laser treatment of a giant hemangioma of head and neck region of an infant using the laryngeal mask airway. ( 15662735 )
2004
35
Giant hemangioma of the liver: MR imaging characteristics in 24 patients. ( 12670595 )
2003
36
Hemoperitoneum from a spontaneous rupture of a giant hemangioma of the liver: report of a case. ( 12768374 )
2003
37
Capsular retraction in hepatic giant hemangioma: CT and MR features. ( 11116357 )
2001
38
Hepatobiliary and pancreatic: a woman with abdominal pain. Giant hemangioma of the liver. ( 11422625 )
2001
39
Metastatic angiosarcoma of the liver preoperatively presenting as giant hemangioma. ( 11070413 )
2000
40
Spontaneous rupture of a giant hemangioma of the liver. ( 11014019 )
2000
41
Successful transcutaneous arterial embolization of a giant hemangioma associated with high-output cardiac failure and Kasabach-Merritt syndrome in a neonate: a case report. ( 10642962 )
1999
42
Prenatal diagnosis of giant hemangioma of the thigh. ( 10659901 )
1999
43
[Interferon treatment of giant hemangioma]. ( 10570861 )
1999
44
Inflammatory process complicating giant hemangioma of the liver: report of three cases. ( 9563958 )
1998
45
Giant hemangioma of the sternocleidomastoid muscle: report of a case. ( 9024361 )
1997
46
Pedunculated giant hemangioma of liver. ( 9167384 )
1997
47
[Giant hemangioma treated with interferon alpha-2a]. ( 14685404 )
1997
48
Giant hemangioma in infant. A case presentation and literature review. ( 9157830 )
1996
49
A case of giant hemangioma of the liver presenting with fever of unknown origin. ( 7986396 )
1994
50
Successful management of an infant with a giant hemangioma of the retroperitoneum and Kasabach-Merritt syndrome with alpha-interferon. ( 8263701 )
1993

Variations for Giant Hemangioma

Expression for Giant Hemangioma

Search GEO for disease gene expression data for Giant Hemangioma.

Pathways for Giant Hemangioma

GO Terms for Giant Hemangioma

Cellular components related to Giant Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 F2 F3 IFNA2 PLG SERPINC1 SERPINF2
2 extracellular region GO:0005576 9.76 DLL1 F2 F3 IFNA2 PLG SERPINC1
3 cell surface GO:0009986 9.67 F3 PLG SERPINF2 TGFB1
4 platelet alpha granule lumen GO:0031093 9.5 PLG SERPINF2 TGFB1
5 blood microparticle GO:0072562 9.35 F2 PLG SERPINC1 SERPINF2 TGFB1
6 collagen-containing extracellular matrix GO:0062023 9.1 F3 IFNA2 PLG SERPINC1 SERPINF2 TGFB1

Biological processes related to Giant Hemangioma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.69 F3 IFNA2 TGFB1
2 cellular protein metabolic process GO:0044267 9.65 F2 PLG SERPINC1
3 platelet degranulation GO:0002576 9.54 PLG SERPINF2 TGFB1
4 inner ear development GO:0048839 9.52 DLL1 TGFB1
5 positive regulation of collagen biosynthetic process GO:0032967 9.5 F2 SERPINF2 TGFB1
6 acute-phase response GO:0006953 9.49 F2 SERPINF2
7 negative regulation of myoblast differentiation GO:0045662 9.46 DLL1 TGFB1
8 positive regulation of protein localization to nucleus GO:1900182 9.43 F2 TGFB1
9 fibrinolysis GO:0042730 9.43 F2 PLG SERPINF2
10 regulation of blood coagulation GO:0030193 9.4 F2 SERPINC1
11 negative regulation of fibrinolysis GO:0051918 9.33 F2 PLG SERPINF2
12 hemostasis GO:0007599 9.26 F2 F3 PLG SERPINC1
13 blood coagulation GO:0007596 9.02 F2 F3 IFNA2 PLG SERPINC1

Molecular functions related to Giant Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 F2 F3 PLG
2 protease binding GO:0002020 8.8 F3 SERPINC1 SERPINF2

Sources for Giant Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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