MCID: GNT005
MIFTS: 34

Giant Hemangioma

Categories: Blood diseases

Aliases & Classifications for Giant Hemangioma

MalaCards integrated aliases for Giant Hemangioma:

Name: Giant Hemangioma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5774
NCIt 50 C27777
UMLS 73 C1333817

Summaries for Giant Hemangioma

MalaCards based summary : Giant Hemangioma is related to hemangioma of liver and purpura. An important gene associated with Giant Hemangioma is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). Affiliated tissues include liver, spleen and tongue, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Giant Hemangioma

Diseases related to Giant Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 hemangioma of liver 30.4 F2 IFNA2
2 purpura 29.8 F2 F3 SERPINC1
3 thrombosis 29.6 F2 F3 SERPINC1
4 budd-chiari syndrome 29.6 F2 F3 SERPINC1
5 disseminated intravascular coagulation 29.5 F2 F3 SERPINC1 SERPINF2
6 hemangioma 10.7
7 thrombocytopenia 10.3
8 endocarditis 10.2 F2 SERPINC1
9 retinal artery occlusion 10.2 F2 SERPINC1
10 spinal cord infarction 10.2 F2 SERPINC1
11 prothrombin deficiency, congenital 10.2 F2 SERPINC1
12 ischemic colitis 10.2 F2 SERPINC1
13 subendocardial myocardial infarction 10.2 F2 SERPINC1
14 sneddon syndrome 10.2 F2 SERPINC1
15 osteonecrosis 10.2 F2 SERPINC1
16 esophageal varix 10.2 F2 SERPINC1
17 antithrombin iii deficiency 10.2 F2 SERPINC1
18 post-thrombotic syndrome 10.2 F2 SERPINC1
19 hypersplenism 10.2 F2 SERPINC1
20 hemangioma-thrombocytopenia syndrome 10.2
21 central retinal vein occlusion 10.2 F2 SERPINC1
22 retinal vein occlusion 10.2 F2 SERPINC1
23 portal vein thrombosis 10.2 F2 SERPINC1
24 dysfibrinogenemia 10.2 F2 SERPINC1
25 hepatitis d 10.2 F2 IFNA2
26 platelet aggregation, spontaneous 10.1 SERPINC1 SERPINF2
27 cold urticaria 10.1 SERPINC1 SERPINF2
28 placental abruption 10.1 F2 SERPINC1
29 protein c deficiency 10.1 F2 SERPINC1
30 afibrinogenemia 10.1 F2 F3
31 ischemic optic neuropathy 10.1 F2 SERPINC1
32 intermittent claudication 10.1 F2 SERPINC1
33 heparin-induced thrombocytopenia 10.1 F3 SERPINC1
34 hemophilia 10.1 F2 F3
35 nonarteritic anterior ischemic optic neuropathy 10.1 F2 SERPINC1
36 prothrombin deficiency 10.1 F2 F3
37 cerebral sinovenous thrombosis 10.1 F2 F3
38 qualitative platelet defect 10.1 F2 F3
39 alcohol-related birth defect 10.1 F2 F3
40 hantavirus pulmonary syndrome 10.1 F2 F3
41 von willebrand disease, type 1 10.1 F2 F3
42 vascular hemostatic disease 10.1 F2 F3
43 splenic disease 10.1 F2 F3
44 factor xii deficiency 10.1 F3 SERPINC1
45 acute poststreptococcal glomerulonephritis 10.1 PLG SERPINF2
46 coronary thrombosis 10.1 F3 SERPINC1
47 pulmonary immaturity 10.1 F3 SERPINC1
48 acute cor pulmonale 10.1 PLG SERPINF2
49 conjunctival disease 10.1 IFNA2 PLG
50 acute pulmonary heart disease 10.1 PLG SERPINF2

Graphical network of the top 20 diseases related to Giant Hemangioma:



Diseases related to Giant Hemangioma

Symptoms & Phenotypes for Giant Hemangioma

MGI Mouse Phenotypes related to Giant Hemangioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 DLL1 F2 F3 PLG SERPINC1 TGFB1
2 hematopoietic system MP:0005397 9.73 DLL1 F2 F3 PLG SERPINC1 TGFB1
3 embryo MP:0005380 9.72 DLL1 F2 F3 SERPINC1 TGFB1
4 homeostasis/metabolism MP:0005376 9.7 DLL1 F2 F3 PLG SERPINC1 SERPINF2
5 immune system MP:0005387 9.43 DLL1 F2 F3 PLG SERPINC1 TGFB1
6 nervous system MP:0003631 9.1 DLL1 F2 F3 PLG SERPINC1 TGFB1

Drugs & Therapeutics for Giant Hemangioma

Search Clinical Trials , NIH Clinical Center for Giant Hemangioma

Genetic Tests for Giant Hemangioma

Anatomical Context for Giant Hemangioma

MalaCards organs/tissues related to Giant Hemangioma:

41
Liver, Spleen, Tongue, Testes, Heart, Spinal Cord, Placenta

Publications for Giant Hemangioma

Articles related to Giant Hemangioma:

(show top 50) (show all 90)
# Title Authors Year
1
Detection and monitoring of postinterventional success and complications of the liver using contrast-enhanced ultrasound (CEUS) - a case report after interventional treatment of a giant hemangioma. ( 30534665 )
2018
2
Giant hemangioma of anterior mediastinum mimicking bilateral pleural effusion. ( 29354184 )
2017
3
Transoral ultrasonic surgery of pharyngolaryngeal giant hemangioma after ethylene-vinyl alcohol copolymer (Onyx) embolization. ( 28263419 )
2017
4
Resection of Giant Hemangioma of the Tongue Utilizing a Miniature Tourniquet Technique. ( 27391511 )
2016
5
Enucleation is Better for a Giant Hemangioma Proximal to the Hepatic Portal Vascular Structures. ( 27574349 )
2016
6
Pure laparoscopic right hepatectomy for giant hemangioma using anterior approach. ( 27620909 )
2016
7
A rare case of intra and extra testicular varicocele caused by giant hemangioma of liver. ( 30005524 )
2016
8
Tumor size is not a criterion for resection during the management of giant hemangioma of the liver. ( 25923944 )
2015
9
Enucleation of a Giant Hemangioma of Liver: Old School Revisited. ( 26844001 )
2015
10
Giant hemangioma causing budd-Chiari syndrome. ( 25755587 )
2014
11
Feasibility of laparoscopic liver resection for giant hemangioma of greater than 6 cm in diameter. ( 26155263 )
2014
12
Successful liver resection in a giant hemangioma with intestinal obstruction after embolization. ( 23704832 )
2013
13
Giant hemangioma presenting as a scalp mass leading to a craniofacial deformity. ( 24431843 )
2013
14
Airway management in a toddler with a giant hemangioma of the tongue. ( 23429176 )
2012
15
Pre-operative arterial embolization of symptomatic giant hemangioma of the liver. ( 22691287 )
2012
16
Resection for progressively growing giant hemangioma of anterior abdominal wall. ( 22808765 )
2012
17
Hepatic angiomyolipoma with a giant hemangioma. ( 22041879 )
2011
18
Robotic right hepatectomy for giant hemangioma in a Jehovah's Witness. ( 20596878 )
2011
19
Laparoscopic partial splenectomy for giant hemangioma misdiagnosed as splenic cyst: a case report. ( 21180283 )
2010
20
Management of giant hemangioma of the liver: resection versus observation. ( 20980175 )
2010
21
Solitary giant hemangioma of the humerus. ( 19968232 )
2009
22
Giant hemangioma of liver presenting as deep vein thrombosis of the lower limbs. ( 20083882 )
2009
23
Elective laparoscopic splenectomy for giant hemangioma: a case report. ( 19123949 )
2009
24
Giant hemangioma. ( 20214002 )
2009
25
Adult Kasabach-Merritt Syndrome due to Hepatic Giant Hemangioma. ( 21103246 )
2009
26
Coagulation of a giant hemangioma in glans penis with holmium laser. ( 18097507 )
2008
27
Recurrent giant hemangioma causing severe respiratory distress. ( 17404885 )
2007
28
Giant hemangioma of the fetal neck, mimicking a teratoma. ( 16445525 )
2006
29
Adult giant hemangioma of the larynx: a case report. ( 16934420 )
2006
30
Antenatal sonographic and magnetic resonance images of a giant hemangioma of the fetal skull. ( 15846768 )
2005
31
Liver transplantation after backtable resection of giant hemangioma. ( 15973725 )
2005
32
Spontaneous rapid regression of a giant hemangioma mimicking a liver abscess. ( 16120941 )
2005
33
Anesthesia during intralesional bare fiber laser treatment of a giant hemangioma of head and neck region of an infant using the laryngeal mask airway. ( 15662735 )
2004
34
Giant hemangioma of the adrenal. ( 15562815 )
2004
35
Hemoperitoneum from a spontaneous rupture of a giant hemangioma of the liver: report of a case. ( 12768374 )
2003
36
Giant hemangioma of the liver: MR imaging characteristics in 24 patients. ( 12670595 )
2003
37
Hepatobiliary and pancreatic: a woman with abdominal pain. Giant hemangioma of the liver. ( 11422625 )
2001
38
Capsular retraction in hepatic giant hemangioma: CT and MR features. ( 11116357 )
2001
39
Spontaneous rupture of a giant hemangioma of the liver. ( 11014019 )
2000
40
Metastatic angiosarcoma of the liver preoperatively presenting as giant hemangioma. ( 11070413 )
2000
41
Prenatal diagnosis of giant hemangioma of the thigh. ( 10659901 )
1999
42
Successful transcutaneous arterial embolization of a giant hemangioma associated with high-output cardiac failure and Kasabach-Merritt syndrome in a neonate: a case report. ( 10642962 )
1999
43
[Interferon treatment of giant hemangioma]. ( 10570861 )
1999
44
Inflammatory process complicating giant hemangioma of the liver: report of three cases. ( 9563958 )
1998
45
[Giant hemangioma treated with interferon alpha-2a]. ( 14685404 )
1997
46
Giant hemangioma of the sternocleidomastoid muscle: report of a case. ( 9024361 )
1997
47
Pedunculated giant hemangioma of liver. ( 9167384 )
1997
48
Giant hemangioma in infant. A case presentation and literature review. ( 9157830 )
1996
49
A case of giant hemangioma of the liver presenting with fever of unknown origin. ( 7986396 )
1994
50
Giant hemangioma of the parotid gland associated with Kasabach-Merritt syndrome: a case report. ( 8450364 )
1993

Variations for Giant Hemangioma

Expression for Giant Hemangioma

Search GEO for disease gene expression data for Giant Hemangioma.

Pathways for Giant Hemangioma

GO Terms for Giant Hemangioma

Cellular components related to Giant Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 F2 F3 IFNA2 PLG SERPINC1 SERPINF2
2 extracellular region GO:0005576 9.76 DLL1 F2 F3 IFNA2 PLG SERPINC1
3 cell surface GO:0009986 9.67 F3 PLG SERPINF2 TGFB1
4 platelet alpha granule lumen GO:0031093 9.5 PLG SERPINF2 TGFB1
5 blood microparticle GO:0072562 9.35 F2 PLG SERPINC1 SERPINF2 TGFB1
6 collagen-containing extracellular matrix GO:0062023 9.1 F3 IFNA2 PLG SERPINC1 SERPINF2 TGFB1

Biological processes related to Giant Hemangioma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.69 F3 IFNA2 TGFB1
2 cellular protein metabolic process GO:0044267 9.65 F2 PLG SERPINC1
3 platelet degranulation GO:0002576 9.54 PLG SERPINF2 TGFB1
4 inner ear development GO:0048839 9.52 DLL1 TGFB1
5 positive regulation of collagen biosynthetic process GO:0032967 9.5 F2 SERPINF2 TGFB1
6 acute-phase response GO:0006953 9.49 F2 SERPINF2
7 negative regulation of myoblast differentiation GO:0045662 9.46 DLL1 TGFB1
8 positive regulation of protein localization to nucleus GO:1900182 9.43 F2 TGFB1
9 fibrinolysis GO:0042730 9.43 F2 PLG SERPINF2
10 regulation of blood coagulation GO:0030193 9.4 F2 SERPINC1
11 negative regulation of fibrinolysis GO:0051918 9.33 F2 PLG SERPINF2
12 hemostasis GO:0007599 9.26 F2 F3 PLG SERPINC1
13 blood coagulation GO:0007596 9.02 F2 F3 IFNA2 PLG SERPINC1

Molecular functions related to Giant Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 F2 F3 PLG
2 protease binding GO:0002020 8.8 F3 SERPINC1 SERPINF2

Sources for Giant Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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