MCID: GNT005
MIFTS: 31

Giant Hemangioma

Categories: Blood diseases

Aliases & Classifications for Giant Hemangioma

MalaCards integrated aliases for Giant Hemangioma:

Name: Giant Hemangioma 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:5774
NCIt 50 C27777
UMLS 72 C1333817

Summaries for Giant Hemangioma

MalaCards based summary : Giant Hemangioma is related to hemangioma of liver and afibrinogenemia. An important gene associated with Giant Hemangioma is IFNA2 (Interferon Alpha 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). Affiliated tissues include liver, spleen and tongue, and related phenotypes are cardiovascular system and respiratory system

Related Diseases for Giant Hemangioma

Diseases related to Giant Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 hemangioma of liver 31.0 IFNA2 F2
2 afibrinogenemia 30.1 F3 F2
3 purpura 29.8 SERPINC1 F3 F2
4 disseminated intravascular coagulation 29.7 SERPINF2 SERPINC1 F3 F2
5 thrombosis 29.6 SERPINC1 F3 F2
6 budd-chiari syndrome 29.6 SERPINC1 F3 F2
7 thrombocytosis 29.5 SERPINC1 F3 F2
8 blood coagulation disease 28.4 SERPINC1 PLG F3 F2
9 hemangioma 10.9
10 platelet aggregation, spontaneous 10.5 SERPINF2 SERPINC1
11 cold urticaria 10.5 SERPINF2 SERPINC1
12 hemangioma-thrombocytopenia syndrome 10.4
13 heparin-induced thrombocytopenia 10.4 SERPINC1 F3
14 mitral valve stenosis 10.4 SERPINC1 HCK
15 thrombocytopenia 10.4
16 retinal artery occlusion 10.4 SERPINC1 F2
17 spinal cord infarction 10.4 SERPINC1 F2
18 prothrombin deficiency, congenital 10.4 SERPINC1 F2
19 hepatitis d 10.4 IFNA2 F2
20 ischemic colitis 10.4 SERPINC1 F2
21 factor xiii deficiency 10.3 SERPINF2 F3
22 subendocardial myocardial infarction 10.3 SERPINC1 F2
23 sneddon syndrome 10.3 SERPINC1 F2
24 osteonecrosis 10.3 SERPINC1 F2
25 angina pectoris 10.3 SERPINF2 SERPINC1
26 factor xii deficiency 10.3 SERPINC1 F3
27 esophageal varix 10.3 SERPINC1 F2
28 hemometra 10.3 HCK F3
29 pulmonary immaturity 10.3 SERPINC1 F3
30 coronary thrombosis 10.3 SERPINC1 F3
31 hypersplenism 10.3 SERPINC1 F2
32 post-thrombotic syndrome 10.3 SERPINC1 F2
33 antithrombin iii deficiency 10.3 SERPINC1 F2
34 pyoderma 10.3 IFNA2 F3
35 central retinal vein occlusion 10.3 SERPINC1 F2
36 retinal vein occlusion 10.3 SERPINC1 F2
37 peyronie disease 10.3 TGFB1 IFNA2
38 hemophilia 10.3 F3 F2
39 prothrombin deficiency 10.3 F3 F2
40 cerebral sinovenous thrombosis 10.3 F3 F2
41 qualitative platelet defect 10.3 F3 F2
42 hantavirus pulmonary syndrome 10.2 F3 F2
43 alcohol-related birth defect 10.2 F3 F2
44 portal vein thrombosis 10.2 SERPINC1 F2
45 von willebrand disease, type 1 10.2 F3 F2
46 penile disease 10.2 TGFB1 IFNA2
47 dysfibrinogenemia 10.2 SERPINC1 F2
48 splenic disease 10.2 F3 F2
49 peyronie's disease 10.2 TGFB1 IFNA2
50 placental abruption 10.2 SERPINC1 F2

Graphical network of the top 20 diseases related to Giant Hemangioma:



Diseases related to Giant Hemangioma

Symptoms & Phenotypes for Giant Hemangioma

MGI Mouse Phenotypes related to Giant Hemangioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 F2 F3 HCK PLG SERPINC1 TGFB1
2 respiratory system MP:0005388 9.02 F2 F3 HCK PLG TGFB1

Drugs & Therapeutics for Giant Hemangioma

Search Clinical Trials , NIH Clinical Center for Giant Hemangioma

Genetic Tests for Giant Hemangioma

Anatomical Context for Giant Hemangioma

MalaCards organs/tissues related to Giant Hemangioma:

41
Liver, Spleen, Tongue, Heart, Lung, Kidney, Eye

Publications for Giant Hemangioma

Articles related to Giant Hemangioma:

(show top 50) (show all 196)
# Title Authors PMID Year
1
Detection and monitoring of postinterventional success and complications of the liver using contrast-enhanced ultrasound (CEUS) - a case report after interventional treatment of a giant hemangioma. 38
30534665 2018
2
[A case of infant giant hemangioma]. 38
30347541 2018
3
Neonatal giant hepatic hemangioma: A case report. 38
30334996 2018
4
[Streptococcal toxic shock syndrome caused by Streptococcus pyogenes: a retrospective study of 15 pediatric cases]. 38
30078239 2018
5
Surgical Management of Giant Hepatic Hemangioma: Single Center's Experience with 144 Patients. 38
29488123 2018
6
[Giant hepatic hemangioma, an uncommon presentation of a frequent disease]. 38
30118469 2018
7
Coexistence of Kasabach-Merritt Syndrome and placental chorioangioma in a premature infant. 38
29991142 2018
8
Giant hemangioma of anterior mediastinum mimicking bilateral pleural effusion. 38
29354184 2017
9
Propranolol in the preoperative treatment of Kasabach-Merritt syndrome: a case report. 38
29073926 2017
10
Intratumoral coagulation by radiofrequency ablation facilitated the laparoscopic resection of giant hepatic hemangioma: a surgical technique report of two cases. 38
28881707 2017
11
Transoral ultrasonic surgery of pharyngolaryngeal giant hemangioma after ethylene-vinyl alcohol copolymer (Onyx) embolization. 38
28263419 2017
12
Characteristics and operative treatment of extremely giant liver hemangioma >20 cm. 38
28126252 2017
13
Pure laparoscopic right hepatectomy for giant hemangioma using anterior approach. 38
27620909 2017
14
A rare case of intra and extra testicular varicocele caused by giant hemangioma of liver. 38
30005524 2016
15
Enucleation is Better for a Giant Hemangioma Proximal to the Hepatic Portal Vascular Structures. 38
27574349 2016
16
Resection of Giant Hemangioma of the Tongue Utilizing a Miniature Tourniquet Technique. 38
27391511 2016
17
Successful treatment by coil embolization for infantile hemangioma with Kasabach-Meritt syndrome of newborn. 38
26044386 2015
18
Tumor size is not a criterion for resection during the management of giant hemangioma of the liver. 38
25923944 2015
19
Management of Giant Hepatic Hemangioma in Atypical Localization; Report of a Case and Literature Review. 38
26146110 2015
20
Enucleation of a Giant Hemangioma of Liver: Old School Revisited. 38
26844001 2015
21
Giant hemangioma causing budd-Chiari syndrome. 38
25755587 2014
22
Feasibility of laparoscopic liver resection for giant hemangioma of greater than 6 cm in diameter. 38
26155263 2014
23
Right hepatectomy for giant cavernous hemangioma with diffuse hemangiomatosis around Glisson's capsule. 38
25009410 2014
24
[Pingyangmycin injection under suspension laryngoscopy for giant hemangioma at hypopharynx and laryngeal in 12 cases hemangioma at hypopharynx and laryngeal in 12 cases]. 38
25195276 2014
25
Extended hemangioma from pharynx to esophagus that could be misdiagnosed as an esophageal varix on endoscopy. 38
24164602 2013
26
Giant mesenteric hemangioma of cavernous and venous mixed type: a rare case report. 38
24168418 2013
27
[Giant hemangioma of the rib]. 38
23917134 2013
28
Management of hemangioma of the liver: surgical therapy or observation? 38
23354918 2013
29
Giant hemangioma presenting as a scalp mass leading to a craniofacial deformity. 38
24431843 2013
30
Successful liver resection in a giant hemangioma with intestinal obstruction after embolization. 38
23704832 2013
31
Management of giant liver hemangiomas: an update. 38
23445235 2013
32
Spontaneous rupture of giant liver hemangioma: case report. 38
23539918 2013
33
Airway management in a toddler with a giant hemangioma of the tongue. 38
23429176 2012
34
Recurrent giant hemangiomas of liver: Report of two rare cases with literature review. 38
23494295 2012
35
Resection for progressively growing giant hemangioma of anterior abdominal wall. 38
22808765 2012
36
[The treatment of the sponateneous biloma and choledocholithiasis after the liver resection on the reason of the giant hemangioma]. 38
22810542 2012
37
Pre-operative arterial embolization of symptomatic giant hemangioma of the liver. 38
22691287 2012
38
[Successful anesthetic management for resection of a giant hepatic hemangioma with Kasabach-Merritt syndrome using FloTrac system]. 38
22175175 2011
39
Resection of giant liver hemangioma in a pregnant woman with coagulopathy: Case report and literature review. 38
22905301 2011
40
Surgical Management for Giant liver Hemangiomas Greater Than 20 cm in Size. 38
21814606 2011
41
A symptomatic giant hepatic hemangioma treated with hepatectomy. 38
21389646 2011
42
Hepatic angiomyolipoma with a giant hemangioma. 38
22041879 2011
43
Robotic right hepatectomy for giant hemangioma in a Jehovah's Witness. 38
20596878 2011
44
Management of giant hemangioma of the liver: resection versus observation. 38
20980175 2010
45
Laparoscopic partial splenectomy for giant hemangioma misdiagnosed as splenic cyst: a case report. 38
21180283 2010
46
Giant liver hemangioma resected by trisectorectomy after efficient volume reduction by transcatheter arterial embolization: a case report. 38
20731839 2010
47
Resection of a rapid-growing 40-cm giant liver hemangioma. 38
21161011 2010
48
Solitary giant hemangioma of the humerus. 38
19968232 2009
49
Brachial plexus paralysis due to giant cavernous hemangioma with Kasabach-Merritt syndrome: successful management with interferon alpha. 38
19929246 2009
50
Adult Kasabach-Merritt Syndrome due to Hepatic Giant Hemangioma. 38
21103246 2009

Variations for Giant Hemangioma

Expression for Giant Hemangioma

Search GEO for disease gene expression data for Giant Hemangioma.

Pathways for Giant Hemangioma

GO Terms for Giant Hemangioma

Cellular components related to Giant Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 TGFB1 SERPINF2 SERPINC1 PLG IFNA2 F3
2 extracellular space GO:0005615 9.76 TGFB1 SERPINF2 SERPINC1 PLG IFNA2 F3
3 cell surface GO:0009986 9.67 TGFB1 SERPINF2 PLG F3
4 platelet alpha granule lumen GO:0031093 9.5 TGFB1 SERPINF2 PLG
5 blood microparticle GO:0072562 9.35 TGFB1 SERPINF2 SERPINC1 PLG F2
6 collagen-containing extracellular matrix GO:0062023 9.1 TGFB1 SERPINF2 SERPINC1 PLG IFNA2 F3

Biological processes related to Giant Hemangioma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.7 TGFB1 SERPINF2 APELA
2 cellular protein metabolic process GO:0044267 9.67 SERPINC1 PLG F2
3 cytokine-mediated signaling pathway GO:0019221 9.67 TGFB1 IFNA2 HCK F3
4 platelet degranulation GO:0002576 9.58 TGFB1 SERPINF2 PLG
5 acute-phase response GO:0006953 9.54 SERPINF2 F2
6 lipopolysaccharide-mediated signaling pathway GO:0031663 9.51 TGFB1 HCK
7 positive regulation of collagen biosynthetic process GO:0032967 9.5 TGFB1 SERPINF2 F2
8 endoderm development GO:0007492 9.48 TGFB1 APELA
9 positive regulation of protein localization to nucleus GO:1900182 9.46 TGFB1 F2
10 regulation of blood coagulation GO:0030193 9.43 SERPINC1 F2
11 fibrinolysis GO:0042730 9.43 SERPINF2 PLG F2
12 blood coagulation GO:0007596 9.35 SERPINC1 PLG IFNA2 F3 F2
13 negative regulation of fibrinolysis GO:0051918 9.33 SERPINF2 PLG F2
14 hemostasis GO:0007599 8.92 SERPINC1 PLG F3 F2

Molecular functions related to Giant Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 PLG F3 F2
2 protease binding GO:0002020 8.8 SERPINF2 SERPINC1 F3

Sources for Giant Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....