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GPC
MCID: GNT006
MIFTS: 38

Giant Papillary Conjunctivitis (GPC)

Categories: Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Giant Papillary Conjunctivitis

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MalaCards integrated aliases for Giant Papillary Conjunctivitis:

Name: Giant Papillary Conjunctivitis 12 74 52 15
Conjunctivitis, Giant Papillary 71
Conjunctivitis Giant Papillary 54
Gpc 52

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2457
MeSH 43 D003233
NCIt 49 C34507
SNOMED-CT 67 231857004
UMLS 71 C0009769
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Summaries for Giant Papillary Conjunctivitis

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MalaCards based summary : Giant Papillary Conjunctivitis, also known as conjunctivitis, giant papillary, is related to vernal conjunctivitis and blepharitis. An important gene associated with Giant Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells.

Wikipedia : 74 Allergic conjunctivitis (AC) is inflammation of the conjunctiva (the membrane covering the white part of... more...

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Related Diseases for Giant Papillary Conjunctivitis

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Diseases related to Giant Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
# Related Disease Score Top Affiliating Genes
1 vernal conjunctivitis 30.9 RNASE3 IL4
2 blepharitis 30.2 LTF IL6 IL4
3 vernal keratoconjunctivitis 30.1 RNASE3 IL4 CCL24 CCL11
4 allergic conjunctivitis 29.6 RNASE3 IL4 CXCL8 CCL11
5 eye disease 29.6 IL6 IL4 CXCL8 CCL11
6 allergic hypersensitivity disease 29.2 RNASE3 IL4 CXCL8 CCL24 CCL11
7 proteasome-associated autoinflammatory syndrome 1 29.1 RNASE3 IL6 IL4 CXCL8 CCL11
8 conjunctivitis 29.0 RNASE3 IL7 IL6 IL4 CXCL9 CXCL8
9 keratoconjunctivitis 28.7 RNASE3 IL6 IL4 CXCL9 CXCL8 CCL24
10 papillary conjunctivitis 27.8 PRG2 LTF IL7 IL6 IL4 IL11
11 blood group, gerbich system 11.6
12 eosinophilic gastritis 10.4 CCL24 CCL11
13 sodoku disease 10.4 IL11 CCL11
14 vulvovaginitis 10.3 CXCL8 CCL11
15 eales disease 10.3 IL6 IL4
16 ptosis 10.3
17 idiopathic anterior uveitis 10.3 IL6 CXCL8
18 streptococcal toxic-shock syndrome 10.3 IL6 CXCL8
19 acute transverse myelitis 10.3 IL6 CXCL8
20 transverse myelitis 10.3 IL6 CXCL8
21 scabies 10.3 CXCL8 CCL11
22 fuchs' heterochromic uveitis 10.3 IL6 CXCL8
23 osteitis fibrosa 10.3 IL6 IL11
24 orchitis 10.2 IL6 IL4
25 lymphocytic choriomeningitis 10.2
26 fungal meningitis 10.2 IL6 IL4
27 recurrent corneal erosion 10.2 IL6 CXCL8
28 denture stomatitis 10.2 IL6 CXCL8
29 pouchitis 10.2 LTF CXCL8
30 pyuria 10.2 IL6 CXCL8
31 haemophilus influenzae 10.2 LTF CXCL8
32 progressive myoclonus epilepsy 8 10.2 IL6 CXCL8
33 chlamydia pneumonia 10.2 IL6 CXCL8
34 juvenile arthritis 10.2 IL6 CXCL8
35 peptic esophagitis 10.2 IL6 CXCL8
36 pemphigoid gestationis 10.2 RNASE3 CCL11
37 adhesive otitis media 10.2 RNASE3 CCL11
38 cough variant asthma 10.2 RNASE3 IL4
39 periapical periodontitis 10.2 IL6 CXCL8
40 dental pulp disease 10.2 IL6 CXCL8
41 autoimmune disease of eyes, ear, nose and throat 10.2 IL6 IL4
42 opisthorchiasis 10.2 IL4 CXCL8
43 angiostrongyliasis 10.2 IL4 CCL24 CCL11
44 toxocariasis 10.2 RNASE3 IL4
45 cardiomyopathy, familial hypertrophic, 20 10.2 IL6 CXCL8
46 eosinophilic meningitis 10.2 IL4 CCL24 CCL11
47 vaginal discharge 10.2 IL6 CXCL8
48 trichomoniasis 10.2 IL6 CXCL8
49 elephantiasis 10.2 RNASE3 IL4
50 funisitis 10.2 IL6 CXCL8

Graphical network of the top 20 diseases related to Giant Papillary Conjunctivitis:



Diseases related to Giant Papillary Conjunctivitis
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Symptoms & Phenotypes for Giant Papillary Conjunctivitis

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Drugs & Therapeutics for Giant Papillary Conjunctivitis

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Drugs for Giant Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Loteprednol Approved, Experimental Phase 4 129260-79-3, 82034-46-6 9865442 444025
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Gastrointestinal Agents Phase 4
9 Hormones Phase 4
10 Methylprednisolone Acetate Phase 4
11 Hormone Antagonists Phase 4
12 Anti-Allergic Agents Phase 4
13 glucocorticoids Phase 4
14 Antineoplastic Agents, Hormonal Phase 4
15 Neuroprotective Agents Phase 4
16 Antiemetics Phase 4
17 Anti-Inflammatory Agents Phase 4
18 Protective Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Post Marketing Surveillance to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5% Completed NCT01437982 Phase 4 Loteprednol Etabonate;Prednisolone Acetate 1% Oph Susp
2 Comparison Between Nylon and Polyglactin Corneal Suture in Pediatric Cataract Surgery: a Randomized Controlled Clinical Trial Recruiting NCT03812640

Search NIH Clinical Center for Giant Papillary Conjunctivitis

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Genetic Tests for Giant Papillary Conjunctivitis

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Anatomical Context for Giant Papillary Conjunctivitis

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MalaCards organs/tissues related to Giant Papillary Conjunctivitis:

40
Eye, Testes, T Cells, Skin, B Cells, Neutrophil
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Publications for Giant Papillary Conjunctivitis

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Articles related to Giant Papillary Conjunctivitis:

(show top 50) (show all 248)
# Title Authors PMID Year
1
Giant papillary conjunctivitis. 54 61
18769199 2008
2
Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. 61 54
17760635 2007
3
Increased eotaxin in tears of patients wearing contact lenses. 61 54
15502476 2004
4
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. 61 54
14566648 2003
5
Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases. 54 61
10682966 2000
6
Cytokine production and mRNA expression by conjunctival T-cell lines in chronic allergic eye disease. 61 54
10469030 1999
7
Lactoferrin in tears in contact lens wearers. 61 54
9108979 1997
8
Giant papillary conjunctivitis: A review. 61
32339665 2020
9
Ocular allergy test and biomarkers on the ocular surface: Clinical test for evaluating the ocular surface condition in allergic conjunctival diseases. 61
32563624 2020
10
Potential Biomarkers for Allergic Conjunctival Diseases. 61
32097185 2020
11
Tear Inflammatory Molecules in Contact Lens Wearers: A Literature Review. 61
30963963 2020
12
Contact lens complications among wearers in Ghana. 61
31784334 2019
13
[Application of corticosteroid eye drops for allergic eye diseases in children]. 61
30798620 2019
14
Surgical treatment outcome of medically refractory huge giant papillary conjunctivitis. 61
29260110 2017
15
[Characteristics of allergic conjunctivitis with positive skin prick test]. 61
28926887 2017
16
Japanese guidelines for allergic conjunctival diseases 2017. 61
28209324 2017
17
Contact Lenses for Keratoconus- Current Practice. 61
28932340 2017
18
A retrospective analysis of vision correction and safety in keratoconus patients wearing Toris K soft contact lenses. 61
26895272 2016
19
An update on ocular allergy. 61
27490123 2016
20
Allergic manifestations of contact lens wearing. 61
27518840 2016
21
Changes in the Eye Microbiota Associated with Contact Lens Wearing. 61
27006462 2016
22
[Ocular prosthetics. Fitting, daily use and complications]. 61
26160105 2016
23
[. Oсumethyl in the treatment of allergic diseases of eyelids and conjunctiva]. 61
27911431 2016
24
Treatment of asymmetrical vernal keratoconjunctivitis with supratarsal corticosteroid injection. 61
25410033 2014
25
Compliance study of contact lens wearers in Japan--part 2: evaluation of a subscribed membership system. 61
25162289 2014
26
[Giant papillary conjunctivitis]. 61
24799171 2014
27
Pharmacokinetic evaluation of topical calcineurin inhibitors for treatment of allergic conjunctivitis. 61
24490943 2014
28
A case of recalcitrant bacterial conjunctivitis. 61
24555257 2013
29
Allergic conjunctivitis: an update on diagnosis and management. 61
23974684 2013
30
Allergic conjunctivitis: a comprehensive review of the literature. 61
23497516 2013
31
Diagnostics and new developments in the treatment of ocular allergies. 61
22382607 2012
32
[Evaluation of the efficacy of subjective symptoms, objective findings, and of a total tear IgE detection kit in diagnosis of allergic conjunctival diseases]. 61
22690539 2012
33
Topical interferon alfa-2b for management of ocular surface squamous neoplasia in 23 cases: outcomes based on American Joint Committee on Cancer classification. 61
22332208 2012
34
Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate. 61
22536546 2012
35
[Follicular conjunctivitis of unknown origin]. 61
22134344 2012
36
Ocular allergy in the Asia Pacific region. 61
22053306 2011
37
Cyclosporine a eye drop-induced elongated eyelashes: a case report. 61
22291642 2011
38
Not only hard contact lens wear but also soft contact lens wear may be associated with blepharoptosis. 61
21816253 2011
39
Japanese guideline for allergic conjunctival diseases. 61
21636966 2011
40
Recent patents and emerging therapeutics in the treatment of allergic conjunctivitis. 61
21171952 2011
41
A survey of contact lens complications in Singapore. 61
21139501 2011
42
The management of allergic eye diseases in primary eye care. 61
19879797 2009
43
[Ophthalmology]. 61
19899534 2009
44
Prevalence of contact lens-related complications: UCLA contact lens study. 61
19474751 2009
45
[Therapeutic contact lenses and the advantages of high Dk materials]. 61
19274406 2008
46
Use of sealant (HFG) in corneal perforations. 61
18812759 2008
47
Nutritional therapies for ocular disorders: Part Three. 61
18950246 2008
48
Long-term results of a suture burial technique. 61
18465718 2008
49
Treatment of ocular inflammatory conditions with loteprednol etabonate. 61
18245274 2008
50
Giant papillary conjunctivitis. 61
18282547 2008
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Variations for Giant Papillary Conjunctivitis

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Expression for Giant Papillary Conjunctivitis

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Search GEO for disease gene expression data for Giant Papillary Conjunctivitis.
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Pathways for Giant Papillary Conjunctivitis

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Pathways related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.82 RNASE3 PRG2 LTF IL7 IL6 IL4
2
ERK Signaling 63
Show member pathways
 13.58 PRG2 IL7 IL6 IL4 IL11 CXCL9
3
PEDF Induced Signaling 63
Show member pathways
 13.48 IL7 IL6 IL4 IL11 CXCL9 CXCL8
4
TGF-Beta Pathway 63
Show member pathways
 13.37 IL7 IL6 IL4 IL11 CXCL8 CCL24
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.19 IL7 IL6 IL4 IL11 CXCL8 CCL11
6
Akt Signaling 63
Show member pathways
 13.12 IL7 IL6 IL4 IL11 CXCL9 CXCL8
7
PAK Pathway 63
Show member pathways
 12.93 IL7 IL6 IL4 IL11 CXCL9 CXCL8
8
CCR5 Pathway in Macrophages 63
Show member pathways
 12.7 CXCL9 CXCL8 CCL24 CCL11
9
Pathways in cancer 36
12.66 IL7 IL6 IL4 CXCL8
10
JAK-STAT signaling pathway 36
Show member pathways
 12.31 IL7 IL6 IL4 IL11
11
Allograft rejection 1 36
Show member pathways
 12.24 RNASE3 PRG2 IL6 IL4 CXCL9 CXCL8
12
IL-17 Family Signaling Pathways 64
Show member pathways
 12.2 IL6 IL4 CXCL8 CCL11
13
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.17 IL6 CXCL9 CXCL8 CCL24 CCL11
14
Bacterial infections in CF airways 22
Show member pathways
 11.94 IL6 IL4 IL11 CXCL8 CCL11
15
Spinal Cord Injury 1
11.88 IL6 IL4 CXCL8
16
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.88 IL7 IL6 IL4 IL11
17
Interleukin-4 and 13 signaling 65
11.85 IL6 IL4 CXCL8 CCL11
18
Hematopoietic cell lineage 36
11.77 IL7 IL6 IL4 IL11
19
Rheumatoid arthritis 36
11.75 IL6 IL11 CXCL8
20
Glucocorticoid receptor regulatory network 1
11.68 IL6 IL4 CXCL8
21
Lung fibrosis 1
11.5 IL6 IL4 CXCL8 CCL11
22
Interleukin-10 signaling 65
11.42 IL6 IL4 CXCL8
23
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.4 IL6 CXCL8 CCL11
24
Development and heterogeneity of the ILC family 1
11.21 IL7 IL6 IL4
25
Cytokines and Inflammatory Response 1
10.92 IL7 IL6 IL4 IL11
26
Overview of nanoparticle effects 1
10.91 IL6 CXCL8
27
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
10.7 IL6 IL4
28
G-protein signaling_Rap2B regulation pathway 22
10.18 PRG2 IL7 IL6 IL4 IL11 CXCL9
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GO Terms for Giant Papillary Conjunctivitis

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Cellular components related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 RNASE3 LTF IL7 IL6 IL4 IL11
2 extracellular region GO:0005576 9.36 RNASE3 PRG2 LTF IL7 IL6 IL4

Biological processes related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.01 CCL11 CCL24 CXCL8 CXCL9 IL11 IL4
2 positive regulation of cell proliferation GO:0008284 9.91 IL11 IL4 IL6 IL7
3 negative regulation of apoptotic process GO:0043066 9.91 IL4 IL6 IL7 LTF
4 inflammatory response GO:0006954 9.83 CCL11 CCL24 CXCL8 CXCL9 IL6
5 cellular response to lipopolysaccharide GO:0071222 9.77 CXCL8 CXCL9 IL6
6 chemotaxis GO:0006935 9.76 CCL11 CCL24 CXCL8 CXCL9
7 positive regulation of angiogenesis GO:0045766 9.74 CCL11 CCL24 CXCL8
8 cellular response to tumor necrosis factor GO:0071356 9.71 CCL11 CCL24 CXCL8
9 defense response to Gram-negative bacterium GO:0050829 9.7 IL6 LTF RNASE3
10 cellular response to interleukin-1 GO:0071347 9.69 CCL11 CCL24 CXCL8
11 humoral immune response GO:0006959 9.67 IL6 IL7 LTF
12 monocyte chemotaxis GO:0002548 9.65 CCL11 CCL24 IL6
13 negative regulation of neurogenesis GO:0050768 9.62 CCL11 IL6
14 neutrophil chemotaxis GO:0030593 9.62 CCL11 CCL24 CXCL8 CXCL9
15 eosinophil chemotaxis GO:0048245 9.59 CCL11 CCL24
16 leukocyte chemotaxis GO:0030595 9.58 CXCL8 CXCL9
17 positive regulation of T cell differentiation GO:0045582 9.58 IL4 IL7
18 positive regulation of chemokine production GO:0032722 9.56 IL6 IL7
19 chemokine-mediated signaling pathway GO:0070098 9.56 CCL11 CCL24 CXCL8 CXCL9
20 positive regulation of myoblast fusion GO:1901741 9.55 CXCL9 IL4
21 innate immune response in mucosa GO:0002227 9.54 IL4 LTF RNASE3
22 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.46 CXCL8 CXCL9 LTF RNASE3
23 cytokine-mediated signaling pathway GO:0019221 9.43 CCL11 CXCL8 IL11 IL4 IL6 IL7
24 immune response GO:0006955 9.23 CCL11 CCL24 CXCL8 CXCL9 IL4 IL6

Molecular functions related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 IL7 IL6 IL4 IL11
2 cytokine receptor binding GO:0005126 9.37 IL7 IL4
3 CXCR chemokine receptor binding GO:0045236 9.32 CXCL9 CXCL8
4 CCR3 chemokine receptor binding GO:0031728 9.26 CCL24 CCL11
5 chemokine activity GO:0008009 9.26 CXCL9 CXCL8 CCL24 CCL11
6 cytokine activity GO:0005125 9.23 IL7 IL6 IL4 IL11 CXCL9 CXCL8
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Sources for Giant Papillary Conjunctivitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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