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MCID: GNT006
MIFTS: 40

Giant Papillary Conjunctivitis

Categories: Eye diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Giant Papillary Conjunctivitis

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MalaCards integrated aliases for Giant Papillary Conjunctivitis:

Name: Giant Papillary Conjunctivitis 12 77 54 15
Conjunctivitis, Giant Papillary 74
Conjunctivitis Giant Papillary 56
Gpc 54

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2457
MeSH 45 D003233
NCIt 51 C34507
UMLS 74 C0009769
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Summaries for Giant Papillary Conjunctivitis

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MalaCards based summary : Giant Papillary Conjunctivitis, also known as conjunctivitis, giant papillary, is related to vernal conjunctivitis and papillary conjunctivitis. An important gene associated with Giant Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Prednisolone phosphate and Loteprednol have been mentioned in the context of this disorder. Affiliated tissues include eye, neutrophil and lung.

Wikipedia : 77 Allergic conjunctivitis is inflammation of the conjunctiva (the membrane covering the white part of the... more...

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Related Diseases for Giant Papillary Conjunctivitis

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Diseases related to Giant Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 vernal conjunctivitis 30.6 IL4 RNASE3
2 papillary conjunctivitis 30.6 CCL11 CXCL8 IL11 IL4
3 conjunctivitis 30.6 CCL11 CXCL8 IL4 RNASE3
4 vernal keratoconjunctivitis 30.0 CCL11 IL4 RNASE3
5 keratoconjunctivitis 29.4 CCL11 CXCL8 IL4 RNASE3
6 blood group, gerbich system 11.5
7 angiostrongyliasis 10.2 CCL11 IL4
8 eosinophilic meningitis 10.2 CCL11 IL4
9 granulomatosis with polyangiitis 10.2
10 eosinophilic gastritis 10.2 CCL11 IL4
11 folliculitis 10.2 CCL11 IL4
12 ptosis 10.2
13 eosinophilic gastroenteritis 10.2 CCL11 RNASE3
14 chronic eosinophilic pneumonia 10.2 CCL11 RNASE3
15 eosinophilic pneumonia 10.2 CCL11 RNASE3
16 cough variant asthma 10.1 IL4 RNASE3
17 inflammatory bowel disease 4 10.1 IL4 RNASE3
18 atopic keratoconjunctivitis 10.1 IL4 RNASE3
19 intrinsic asthma 10.1 IL4 RNASE3
20 latex allergy 10.1 IL4 RNASE3
21 urinary schistosomiasis 10.1 IL4 RNASE3
22 schistosomiasis 10.1 IL4 RNASE3
23 milk allergy 10.1 IL4 RNASE3
24 ocular cicatricial pemphigoid 10.1 IL4 RNASE3
25 leukocyte disease 10.1 CCL11 IL4
26 parasitic helminthiasis infectious disease 10.1 IL4 RNASE3
27 ige responsiveness, atopic 10.1 IL4 RNASE3
28 food allergy 10.1 IL4 RNASE3
29 multiple sclerosis 10.0
30 lymphocytic choriomeningitis 10.0
31 pelvic inflammatory disease 10.0
32 keratoconjunctivitis sicca 10.0 IL4 LTF
33 proctitis 10.0 LTF RNASE3
34 vulvovaginitis 10.0 CCL11 CXCL8
35 scabies 10.0 CCL11 CXCL8
36 periodontitis 10.0 CXCL8 IL4
37 tungiasis 10.0 CXCL8 IL4
38 radiculopathy 10.0 CCL11 CXCL8
39 opisthorchiasis 10.0 CXCL8 IL4
40 blepharoconjunctivitis 9.9 CCL11 IL4 RNASE3
41 chronic conjunctivitis 9.9 CCL11 IL4 RNASE3
42 kimura disease 9.9 CCL11 IL4 RNASE3
43 conjunctival disease 9.9 CCL11 IL4 RNASE3
44 pulmonary eosinophilia 9.9 CCL11 IL4 RNASE3
45 onchocerciasis 9.9 CCL11 IL4 RNASE3
46 nasal cavity disease 9.9 CCL11 IL4 RNASE3
47 cataract 9.9
48 blepharitis 9.9
49 superior limbic keratoconjunctivitis 9.9
50 respiratory allergy 9.9 CCL11 IL4 RNASE3

Graphical network of the top 20 diseases related to Giant Papillary Conjunctivitis:



Diseases related to Giant Papillary Conjunctivitis
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Symptoms & Phenotypes for Giant Papillary Conjunctivitis

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Drugs & Therapeutics for Giant Papillary Conjunctivitis

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Drugs for Giant Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Loteprednol Approved, Experimental Phase 4 82034-46-6, 129260-79-3 9865442 444025
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
6
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
7 Hormones Phase 4
8 Hormone Antagonists Phase 4
9 Gastrointestinal Agents Phase 4
10 glucocorticoids Phase 4
11 Methylprednisolone Acetate Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 Peripheral Nervous System Agents Phase 4
14 Anti-Allergic Agents Phase 4
15 Antiemetics Phase 4
16 Protective Agents Phase 4
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
18 Prednisolone acetate Phase 4
19 Anti-Inflammatory Agents Phase 4
20 Autonomic Agents Phase 4
21 Neuroprotective Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5% Unknown status NCT01437982 Phase 4 Loteprednol Etabonate;Prednisolone Acetate 1% Oph Susp

Search NIH Clinical Center for Giant Papillary Conjunctivitis

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Genetic Tests for Giant Papillary Conjunctivitis

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Anatomical Context for Giant Papillary Conjunctivitis

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MalaCards organs/tissues related to Giant Papillary Conjunctivitis:

42
Eye, Neutrophil, Lung, Skin, Bone, Tonsil
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Publications for Giant Papillary Conjunctivitis

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Articles related to Giant Papillary Conjunctivitis:

(show top 50) (show all 100)
# Title Authors Year
1
Surgical treatment outcome of medically refractory huge giant papillary conjunctivitis. ( 29260110 )
2017
2
Giant papillary conjunctivitis. ( 18769199 )
2008
3
Filtering bleb-induced giant papillary conjunctivitis. ( 17826299 )
2008
4
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. ( 18216583 )
2008
5
Giant papillary conjunctivitis. ( 18282547 )
2008
6
Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. ( 17760635 )
2007
7
M cells are involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis. ( 17557145 )
2007
8
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. ( 16767372 )
2006
9
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. ( 15677951 )
2005
10
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 14566648 )
2003
11
Contact lens chemistry and giant papillary conjunctivitis. ( 12772728 )
2003
12
Giant papillary conjunctivitis associated with an ocular prosthesis. ( 12366372 )
2001
13
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study ( 10844086 )
2000
14
Meibomian gland status and prevalence of giant papillary conjunctivitis in contact lens wearers. ( 15326900 )
2000
15
Giant papillary conjunctivitis--a review. ( 10337425 )
1999
16
Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. ( 10410873 )
1999
17
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. ( 10444049 )
1999
18
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. ( 10703125 )
1999
19
Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 9785608 )
1998
20
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. ( 9124242 )
1997
21
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. ( 9001768 )
1997
22
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. ( 8755197 )
1996
23
Localised giant papillary conjunctivitis secondary to a dermolipoma. ( 7556754 )
1995
24
Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. ( 7586473 )
1995
25
Contact lens type, material, and deposits and giant papillary conjunctivitis. ( 7712614 )
1995
26
Effect of extended wear disposable contact lenses on tear LTC4 in giant papillary conjunctivitis. ( 22827277 )
1995
27
Giant papillary conjunctivitis. ( 7886881 )
1994
28
Bilateral giant papillary conjunctivitis related to glaucoma drainage surgery blebs. ( 7995075 )
1994
29
Causative factors in unilateral giant papillary conjunctivitis. ( 8495560 )
1993
30
Comparison of the clinical performance of the Acuvue disposable contact lens and CSI lens in patients with giant papillary conjunctivitis. ( 8470716 )
1993
31
Unusual causes of giant papillary conjunctivitis. ( 8458237 )
1993
32
Meibomian gland function and giant papillary conjunctivitis. ( 8420369 )
1993
33
Meibomian gland function and giant papillary conjunctivitis. ( 8420368 )
1993
34
Safety and efficacy of loteprednol etabonate for treatment of papillae in contact lens-associated giant papillary conjunctivitis. ( 8319490 )
1993
35
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). ( 7910133 )
1993
36
Daily enzyme cleaning for giant papillary conjunctivitis. ( 1498575 )
1992
37
Evaluation of tear protein deposits on contact lenses from patients with and without giant papillary conjunctivitis. ( 1499118 )
1992
38
Treatment of giant papillary conjunctivitis with cromolyn sodium. ( 1559288 )
1992
39
Meibomian gland function and giant papillary conjunctivitis. ( 1642294 )
1992
40
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. ( 1499122 )
1992
41
Neutrophil chemotactic factors in the tears of giant papillary conjunctivitis patients. ( 1846131 )
1991
42
Continued contact lens wear in patients with giant papillary conjunctivitis. ( 1904798 )
1991
43
Immunoglobulin deposition on soft contact lenses: relationship to hydrogel structure and mode of use and giant papillary conjunctivitis. ( 2407379 )
1990
44
Association of giant papillary conjunctivitis with seasonal allergies. ( 2320363 )
1990
45
Eosinophil granule major basic protein in contact lenses of patients with giant papillary conjunctivitis. ( 2199092 )
1990
46
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. ( 2196302 )
1990
47
Giant papillary conjunctivitis. ( 2193971 )
1990
48
Some unusual nonallergic causes of giant papillary conjunctivitis. ( 2095029 )
1990
49
Giant papillary conjunctivitis associated with elevated corneal deposits. ( 1706653 )
1990
50
Contact lens induced giant papillary conjunctivitis: a retrospective study. ( 2708768 )
1989
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Variations for Giant Papillary Conjunctivitis

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Expression for Giant Papillary Conjunctivitis

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Search GEO for disease gene expression data for Giant Papillary Conjunctivitis.
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Pathways for Giant Papillary Conjunctivitis

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Pathways related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.53 CCL11 CXCL8 IL11 IL4 LTF RNASE3
2
Akt Signaling 65
Show member pathways
 13.02 CCL11 CXCL8 IL11 IL4
3
Cytokine Signaling in Immune system 67
Show member pathways
 12.96 CCL11 CXCL8 IL11 IL4
4
PAK Pathway 65
Show member pathways
 12.9 CCL11 CXCL8 IL11 IL4
5
Allograft rejection 38 1
Show member pathways
 12.44 CCL11 CXCL8 IL4 RNASE3
6
IL-17 Family Signaling Pathways 66
Show member pathways
 11.94 CCL11 CXCL8 IL4
7
Hematopoietic cell lineage 38
11.59 IL11 IL4
8
Immune response IFN gamma signaling pathway 23
Show member pathways
 11.57 CCL11 CXCL8 IL11 IL4
9
Rheumatoid arthritis 38
11.56 CXCL8 IL11
10
Interleukin-4 and 13 signaling 67
11.55 CCL11 CXCL8 IL4
11
Glucocorticoid receptor regulatory network 1
11.51 CXCL8 IL4
12
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.46 CXCL8 IL4
13
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.42 CCL11 IL4
14
IL4-mediated signaling events 1
11.36 CCL11 IL4
15
Interleukin-10 signaling 67
11.21 CXCL8 IL4
16
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.18 CCL11 CXCL8
17
Th2 Differentiation Pathway 66
11.16 CCL11 IL4
18
Bacterial infections in CF airways 23
Show member pathways
 11.14 CCL11 CXCL8 IL11 IL4
19
Lung fibrosis 1
11.13 CCL11 CXCL8 IL4
20
Cytokines and Inflammatory Response 1
10.94 IL11 IL4
21
G-protein signaling_Rap2B regulation pathway 23
10.57 CCL11 CXCL8 IL11 IL4
22
G-protein signaling_RhoB regulation pathway 23
10.49 CCL11 CXCL8 IL11 IL4
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GO Terms for Giant Papillary Conjunctivitis

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Cellular components related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL11 CXCL8 IL11 IL4 LTF RNASE3
2 extracellular space GO:0005615 9.1 CCL11 CXCL8 IL11 IL4 LTF RNASE3

Biological processes related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.65 CCL11 CXCL8 IL4
2 defense response to Gram-negative bacterium GO:0050829 9.52 LTF RNASE3
3 neutrophil chemotaxis GO:0030593 9.51 CCL11 CXCL8
4 cellular response to interleukin-1 GO:0071347 9.49 CCL11 CXCL8
5 B cell differentiation GO:0030183 9.46 IL11 IL4
6 regulation of signaling receptor activity GO:0010469 9.46 CCL11 CXCL8 IL11 IL4
7 chemokine-mediated signaling pathway GO:0070098 9.43 CCL11 CXCL8
8 antimicrobial humoral response GO:0019730 9.4 LTF RNASE3
9 antibacterial humoral response GO:0019731 9.37 LTF RNASE3
10 negative regulation of endothelial cell apoptotic process GO:2000352 9.32 IL11 IL4
11 innate immune response in mucosa GO:0002227 9.26 LTF RNASE3
12 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.13 CXCL8 LTF RNASE3
13 cytokine-mediated signaling pathway GO:0019221 8.92 CCL11 IL4 IL11 CXCL8

Molecular functions related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.16 CCL11 CXCL8
2 lipopolysaccharide binding GO:0001530 8.96 LTF RNASE3
3 cytokine activity GO:0005125 8.92 CCL11 CXCL8 IL11 IL4
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Sources for Giant Papillary Conjunctivitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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