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GPC
MCID: GNT006
MIFTS: 34

Giant Papillary Conjunctivitis (GPC)

Categories: Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Giant Papillary Conjunctivitis

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MalaCards integrated aliases for Giant Papillary Conjunctivitis:

Name: Giant Papillary Conjunctivitis 12 73 20 15
Conjunctivitis, Giant Papillary 70
Conjunctivitis Giant Papillary 54
Gpc 20

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2457
MeSH 44 D003233
NCIt 50 C34507
SNOMED-CT 67 231857004
UMLS 70 C0009769
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Summaries for Giant Papillary Conjunctivitis

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MalaCards based summary : Giant Papillary Conjunctivitis, also known as conjunctivitis, giant papillary, is related to vernal conjunctivitis and vernal keratoconjunctivitis. An important gene associated with Giant Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include eye, skin and t cells.

Wikipedia : 73 Allergic conjunctivitis (AC) is inflammation of the conjunctiva (the membrane covering the white part of... more...

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Related Diseases for Giant Papillary Conjunctivitis

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Diseases related to Giant Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 301)
# Related Disease Score Top Affiliating Genes
1 vernal conjunctivitis 31.0 RNASE3 IL4
2 vernal keratoconjunctivitis 30.3 RNASE3 IL4 CCL24 CCL11
3 blepharitis 30.2 LTF IL4 CXCL8
4 allergic conjunctivitis 30.0 RNASE3 IL4 CXCL8 CCL11
5 eye disease 29.7 IL6 IL4 CXCL8 CCL11
6 keratoconjunctivitis 29.6 RNASE3 IL6 IL4 CXCL8 CCL24 CCL11
7 conjunctivitis 29.5 RNASE3 IL7 IL6 IL4 CXCL9 CXCL8
8 proteasome-associated autoinflammatory syndrome 1 29.4 RNASE3 IL6 IL4 CXCL8 CCL11
9 papillary conjunctivitis 29.2 LTF IL7 IL6 IL4 IL11 CXCL9
10 allergic disease 29.1 RNASE3 IL6 IL4 CXCL8 CCL24 CCL11
11 blood group, gerbich system 11.3
12 ptosis 10.4
13 pemphigoid 10.3 IL4 CCL11
14 loiasis 10.3 IL4 CCL11
15 trichinosis 10.3 IL4 CCL11
16 eosinophilic gastritis 10.3 CCL24 CCL11
17 strongyloidiasis 10.3 IL4 CCL11
18 sodoku disease 10.3 IL11 CCL11
19 ige responsiveness, atopic 10.2
20 vulvovaginitis 10.2 CXCL8 CCL11
21 scabies 10.2 CXCL8 CCL11
22 tungiasis 10.2 IL4 CXCL8
23 eales disease 10.2 IL6 IL4
24 cervicitis 10.2 IL6 CXCL8
25 idiopathic nephrotic syndrome 10.2 IL6 IL4
26 enterocolitis 10.2 IL6 CXCL8
27 acute asthma 10.2 RNASE3 IL4
28 opisthorchiasis 10.2 IL4 CXCL8
29 taeniasis 10.2 IL6 IL4
30 autoimmune vasculitis 10.2 IL6 IL4
31 adhesive otitis media 10.2 RNASE3 CCL11
32 idiopathic anterior uveitis 10.2 IL6 CXCL8
33 osteitis fibrosa 10.2 IL6 IL11
34 epilepsy, familial temporal lobe, 2 10.2 IL6 IL11
35 atopic keratoconjunctivitis 10.2 RNASE3 IL4
36 eustachian tube disease 10.2 RNASE3 CCL11
37 streptococcal toxic-shock syndrome 10.2 IL6 CXCL8
38 acute transverse myelitis 10.2 IL6 CXCL8
39 transverse myelitis 10.2 IL6 CXCL8
40 patulous eustachian tube 10.2 RNASE3 CCL11
41 cough variant asthma 10.2 RNASE3 IL4
42 fuchs' heterochromic uveitis 10.2 IL6 CXCL8
43 pemphigoid gestationis 10.2 RNASE3 CCL11
44 kimura disease 10.2 RNASE3 IL4
45 primary systemic mycosis 10.2 IL6 IL4
46 suppurative periapical periodontitis 10.2 IL6 CXCL8
47 periapical periodontitis 10.2 IL6 CXCL8
48 timothy grass allergy 10.2 RNASE3 IL4
49 bacterial conjunctivitis 10.2 IL6 CXCL8
50 tracheitis 10.2 IL6 CXCL8

Graphical network of the top 20 diseases related to Giant Papillary Conjunctivitis:



Diseases related to Giant Papillary Conjunctivitis
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Symptoms & Phenotypes for Giant Papillary Conjunctivitis

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Drugs & Therapeutics for Giant Papillary Conjunctivitis

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Search Clinical Trials , NIH Clinical Center for Giant Papillary Conjunctivitis

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Genetic Tests for Giant Papillary Conjunctivitis

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Anatomical Context for Giant Papillary Conjunctivitis

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MalaCards organs/tissues related to Giant Papillary Conjunctivitis:

40
Eye, Skin, T Cells, Neutrophil
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Publications for Giant Papillary Conjunctivitis

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Articles related to Giant Papillary Conjunctivitis:

(show top 50) (show all 252)
# Title Authors PMID Year
1
Giant papillary conjunctivitis. 54 61
18769199 2008
2
Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. 54 61
17760635 2007
3
Increased eotaxin in tears of patients wearing contact lenses. 54 61
15502476 2004
4
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. 54 61
14566648 2003
5
Tear and serum soluble leukocyte activation markers in conjunctival allergic diseases. 54 61
10682966 2000
6
Cytokine production and mRNA expression by conjunctival T-cell lines in chronic allergic eye disease. 61 54
10469030 1999
7
Lactoferrin in tears in contact lens wearers. 54 61
9108979 1997
8
Contact lens complications among wearers in Ghana. 61
31784334 2021
9
Current Knowledge in Allergic Conjunctivitis. 61
33631915 2021
10
Ocular allergy test and biomarkers on the ocular surface: Clinical test for evaluating the ocular surface condition in allergic conjunctival diseases. 61
32563624 2020
11
The Presentation and Surgical Treatment of Peribulbar Dermolipomas. 61
33079762 2020
12
Japanese guidelines for allergic conjunctival diseases 2020. 61
33211650 2020
13
Giant papillary conjunctivitis: A review. 61
32339665 2020
14
Thelaziasis as an uncommon cause of giant papillary conjunctivitis. 61
32586115 2020
15
Potential Biomarkers for Allergic Conjunctival Diseases. 61
32097185 2020
16
Tear Inflammatory Molecules in Contact Lens Wearers: A Literature Review. 61
30963963 2020
17
[Application of corticosteroid eye drops for allergic eye diseases in children]. 61
30798620 2019
18
Surgical treatment outcome of medically refractory huge giant papillary conjunctivitis. 61
29260110 2017
19
[Characteristics of allergic conjunctivitis with positive skin prick test]. 61
28926887 2017
20
Japanese guidelines for allergic conjunctival diseases 2017. 61
28209324 2017
21
Contact Lenses for Keratoconus- Current Practice. 61
28932340 2017
22
A retrospective analysis of vision correction and safety in keratoconus patients wearing Toris K soft contact lenses. 61
26895272 2016
23
An update on ocular allergy. 61
27490123 2016
24
Allergic manifestations of contact lens wearing. 61
27518840 2016
25
Changes in the Eye Microbiota Associated with Contact Lens Wearing. 61
27006462 2016
26
[Ocular prosthetics. Fitting, daily use and complications]. 61
26160105 2016
27
[. Oсumethyl in the treatment of allergic diseases of eyelids and conjunctiva]. 61
27911431 2016
28
Treatment of asymmetrical vernal keratoconjunctivitis with supratarsal corticosteroid injection. 61
25410033 2014
29
Compliance study of contact lens wearers in Japan--part 2: evaluation of a subscribed membership system. 61
25162289 2014
30
[Giant papillary conjunctivitis]. 61
24799171 2014
31
Pharmacokinetic evaluation of topical calcineurin inhibitors for treatment of allergic conjunctivitis. 61
24490943 2014
32
A case of recalcitrant bacterial conjunctivitis. 61
24555257 2013
33
Allergic conjunctivitis: an update on diagnosis and management. 61
23974684 2013
34
Allergic conjunctivitis: a comprehensive review of the literature. 61
23497516 2013
35
Diagnostics and new developments in the treatment of ocular allergies. 61
22382607 2012
36
[Evaluation of the efficacy of subjective symptoms, objective findings, and of a total tear IgE detection kit in diagnosis of allergic conjunctival diseases]. 61
22690539 2012
37
Topical interferon alfa-2b for management of ocular surface squamous neoplasia in 23 cases: outcomes based on American Joint Committee on Cancer classification. 61
22332208 2012
38
Advances in corticosteroid therapy for ocular inflammation: loteprednol etabonate. 61
22536546 2012
39
[Follicular conjunctivitis of unknown origin]. 61
22134344 2012
40
Ocular allergy in the Asia Pacific region. 61
22053306 2011
41
Cyclosporine a eye drop-induced elongated eyelashes: a case report. 61
22291642 2011
42
Not only hard contact lens wear but also soft contact lens wear may be associated with blepharoptosis. 61
21816253 2011
43
Japanese guideline for allergic conjunctival diseases. 61
21636966 2011
44
A survey of contact lens complications in Singapore. 61
21139501 2011
45
Recent patents and emerging therapeutics in the treatment of allergic conjunctivitis. 61
21171952 2011
46
The management of allergic eye diseases in primary eye care. 61
19879797 2009
47
[Ophthalmology]. 61
19899534 2009
48
Prevalence of contact lens-related complications: UCLA contact lens study. 61
19474751 2009
49
[Therapeutic contact lenses and the advantages of high Dk materials]. 61
19274406 2008
50
Use of sealant (HFG) in corneal perforations. 61
18812759 2008
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Variations for Giant Papillary Conjunctivitis

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Expression for Giant Papillary Conjunctivitis

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Search GEO for disease gene expression data for Giant Papillary Conjunctivitis.
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Pathways for Giant Papillary Conjunctivitis

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Pathways related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.81 RNASE3 LTF IL7 IL6 IL4 IL11
2
ERK Signaling 63
Show member pathways
 13.6 IL7 IL6 IL4 IL11 CXCL9 CXCL8
3
PEDF Induced Signaling 63
Show member pathways
 13.45 IL7 IL6 IL4 IL11 CXCL9 CXCL8
4
TGF-Beta Pathway 63
Show member pathways
 13.33 IL7 IL6 IL4 IL11 CXCL8 CCL24
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.18 IL7 IL6 IL4 IL11 CXCL8 CCL11
6
Akt Signaling 63
Show member pathways
 13.07 IL7 IL6 IL4 IL11 CXCL9 CXCL8
7
PAK Pathway 63
Show member pathways
 12.82 IL7 IL6 IL4 IL11 CXCL9 CXCL8
8
CCR5 Pathway in Macrophages 63
Show member pathways
 12.7 CXCL9 CXCL8 CCL24 CCL11
9
Pathways in cancer 36
12.66 IL7 IL6 IL4 CXCL8
10
Allograft rejection 1 36
Show member pathways
 12.65 RNASE3 IL6 IL4 CXCL9 CXCL8 CCL11
11
JAK-STAT signaling pathway 36
Show member pathways
 12.28 IL7 IL6 IL4 IL11
12
IL-17 Family Signaling Pathways 64
Show member pathways
 12.21 IL6 IL4 CXCL8 CCL11
13
Immune response CCR3 signaling in eosinophils 23
Show member pathways
 12.16 CXCL8 CCL24 CCL11
14
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.14 IL6 CXCL9 CXCL8 CCL24 CCL11
15
Spinal Cord Injury 1
11.88 IL6 IL4 CXCL8
16
Bacterial infections in CF airways 23
Show member pathways
 11.87 IL6 IL4 IL11 CXCL8 CCL11
17
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.86 IL7 IL6 IL4 IL11
18
Interleukin-4 and 13 signaling 65
11.84 IL6 IL4 CXCL8 CCL11
19
Rheumatoid arthritis 36
11.75 IL6 IL11 CXCL8
20
Hematopoietic cell lineage 36
11.75 IL7 IL6 IL4 IL11
21
Glucocorticoid receptor regulatory network 1
11.69 IL6 IL4 CXCL8
22
Lung fibrosis 1
11.47 IL6 IL4 CXCL8 CCL11
23
Interleukin-10 signaling 65
11.43 IL6 IL4 CXCL8
24
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.41 IL6 CXCL8 CCL11
25
Development and heterogeneity of the ILC family 1
11.22 IL7 IL6 IL4
26
Overview of nanoparticle effects 1
10.91 IL6 CXCL8
27
Cytokines and Inflammatory Response 1
10.72 IL7 IL6 IL4 IL11
28
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.7 IL6 IL4
29
G-protein signaling_Rap2B regulation pathway 23
10.13 IL7 IL6 IL4 IL11 CXCL9 CXCL8
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GO Terms for Giant Papillary Conjunctivitis

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Cellular components related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 RNASE3 LTF IL7 IL6 IL4 IL11
2 extracellular space GO:0005615 9.32 RNASE3 LTF IL7 IL6 IL4 IL11

Biological processes related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.01 IL7 IL6 IL4 IL11 CXCL9 CXCL8
2 positive regulation of cell proliferation GO:0008284 9.91 IL7 IL6 IL4 IL11
3 negative regulation of apoptotic process GO:0043066 9.9 LTF IL7 IL6 IL4
4 positive regulation of gene expression GO:0010628 9.88 IL7 IL6 IL4 CXCL8
5 inflammatory response GO:0006954 9.85 IL6 CXCL9 CXCL8 CCL24 CCL11
6 cellular response to lipopolysaccharide GO:0071222 9.77 IL6 CXCL9 CXCL8
7 positive regulation of angiogenesis GO:0045766 9.74 CXCL8 CCL24 CCL11
8 cellular response to tumor necrosis factor GO:0071356 9.72 CXCL8 CCL24 CCL11
9 defense response to Gram-negative bacterium GO:0050829 9.7 RNASE3 LTF IL6
10 cellular response to interleukin-1 GO:0071347 9.69 CXCL8 CCL24 CCL11
11 humoral immune response GO:0006959 9.67 LTF IL7 IL6
12 neutrophil chemotaxis GO:0030593 9.67 CXCL9 CXCL8 CCL24 CCL11
13 monocyte chemotaxis GO:0002548 9.65 IL6 CCL24 CCL11
14 chemokine-mediated signaling pathway GO:0070098 9.62 CXCL9 CXCL8 CCL24 CCL11
15 negative regulation of neurogenesis GO:0050768 9.61 IL6 CCL11
16 innate immune response in mucosa GO:0002227 9.61 RNASE3 LTF IL4
17 positive regulation of T cell differentiation GO:0045582 9.58 IL7 IL4
18 eosinophil chemotaxis GO:0048245 9.56 CCL24 CCL11
19 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.56 RNASE3 LTF CXCL9 CXCL8
20 chemotaxis GO:0006935 9.55 RNASE3 CXCL9 CXCL8 CCL24 CCL11
21 positive regulation of myoblast fusion GO:1901741 9.54 IL4 CXCL9
22 cytokine-mediated signaling pathway GO:0019221 9.43 IL7 IL6 IL4 IL11 CXCL8 CCL11
23 immune response GO:0006955 9.17 IL7 IL6 IL4 CXCL9 CXCL8 CCL24

Molecular functions related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 IL7 IL6 IL4 IL11
2 lipopolysaccharide binding GO:0001530 9.43 RNASE3 LTF
3 CCR chemokine receptor binding GO:0048020 9.4 CCL24 CCL11
4 cytokine receptor binding GO:0005126 9.37 IL7 IL4
5 CXCR chemokine receptor binding GO:0045236 9.32 CXCL9 CXCL8
6 CCR3 chemokine receptor binding GO:0031728 9.26 CCL24 CCL11
7 chemokine activity GO:0008009 9.26 CXCL9 CXCL8 CCL24 CCL11
8 cytokine activity GO:0005125 9.23 IL7 IL6 IL4 IL11 CXCL9 CXCL8
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Sources for Giant Papillary Conjunctivitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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