MCID: GNT006
MIFTS: 39

Giant Papillary Conjunctivitis

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Giant Papillary Conjunctivitis

MalaCards integrated aliases for Giant Papillary Conjunctivitis:

Name: Giant Papillary Conjunctivitis 12 76 53 15
Conjunctivitis, Giant Papillary 73
Conjunctivitis Giant Papillary 55
Gpc 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:2457
MeSH 44 D003233
NCIt 50 C34507
SNOMED-CT 68 231857004
UMLS 73 C0009769

Summaries for Giant Papillary Conjunctivitis

MalaCards based summary : Giant Papillary Conjunctivitis, also known as conjunctivitis, giant papillary, is related to vernal conjunctivitis and blepharitis. An important gene associated with Giant Papillary Conjunctivitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Loteprednol and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye and neutrophil.

Wikipedia : 76 Allergic conjunctivitis is inflammation of the conjunctiva (the membrane covering the white part of the... more...

Related Diseases for Giant Papillary Conjunctivitis

Diseases related to Giant Papillary Conjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 vernal conjunctivitis 30.6 IL4 RNASE3
2 blepharitis 30.3 CCL11 IL4
3 vernal keratoconjunctivitis 29.7 CCL11 IL4 RNASE3
4 papillary conjunctivitis 29.6 CCL11 CXCL8 IL11 IL4
5 conjunctivitis 29.6 CCL11 CXCL8 IL4 RNASE3
6 keratoconjunctivitis 28.4 CCL11 CXCL8 IL4 RNASE3
7 blood group, gerbich system 11.3
8 angiostrongyliasis 10.4 CCL11 IL4
9 eosinophilic meningitis 10.4 CCL11 IL4
10 eosinophilic gastritis 10.4 CCL11 IL4
11 folliculitis 10.4 CCL11 IL4
12 eosinophilic gastroenteritis 10.4 CCL11 RNASE3
13 dermatitis herpetiformis 10.3 CCL11 IL4
14 chronic eosinophilic pneumonia 10.3 CCL11 RNASE3
15 cough variant asthma 10.3 IL4 RNASE3
16 inflammatory bowel disease 4 10.3 IL4 RNASE3
17 intrinsic asthma 10.3 IL4 RNASE3
18 atopic keratoconjunctivitis 10.3 IL4 RNASE3
19 eosinophilic pneumonia 10.3 CCL11 RNASE3
20 latex allergy 10.3 IL4 RNASE3
21 urinary schistosomiasis 10.3 IL4 RNASE3
22 milk allergy 10.3 IL4 RNASE3
23 ocular cicatricial pemphigoid 10.2 IL4 RNASE3
24 parasitic helminthiasis infectious disease 10.2 IL4 RNASE3
25 food allergy 10.1 IL4 RNASE3
26 keratoconjunctivitis sicca 10.1 IL4 LTF
27 ige responsiveness, atopic 10.1 IL4 RNASE3
28 proctitis 10.1 LTF RNASE3
29 scabies 10.0 CCL11 CXCL8
30 schistosomiasis 10.0 IL4 RNASE3
31 vulvovaginitis 10.0 CCL11 CXCL8
32 bullous pemphigoid 10.0 CCL11 RNASE3
33 tungiasis 10.0 CXCL8 IL4
34 ptosis 10.0
35 opisthorchiasis 9.9 CXCL8 IL4
36 lymphocytic choriomeningitis 9.9
37 blepharoconjunctivitis 9.9 CCL11 IL4 RNASE3
38 gastrointestinal allergy 9.9 CCL11 IL4 RNASE3
39 chronic conjunctivitis 9.9 CCL11 IL4 RNASE3
40 kimura disease 9.9 CCL11 IL4 RNASE3
41 conjunctival disease 9.9 CCL11 IL4 RNASE3
42 pulmonary eosinophilia 9.9 CCL11 IL4 RNASE3
43 onchocerciasis 9.9 CCL11 IL4 RNASE3
44 leukocyte disease 9.9 CCL11 IL4 RNASE3
45 interstitial cystitis 9.9 CXCL8 IL4
46 allergic hypersensitivity disease 9.9 CCL11 IL4 RNASE3
47 hypereosinophilic syndrome 9.8 CCL11 IL4 RNASE3
48 brucellosis 9.8 CXCL8 IL4
49 dermatitis 9.8 CCL11 IL4 RNASE3
50 status asthmaticus 9.8 CXCL8 RNASE3

Graphical network of the top 20 diseases related to Giant Papillary Conjunctivitis:



Diseases related to Giant Papillary Conjunctivitis

Symptoms & Phenotypes for Giant Papillary Conjunctivitis

Drugs & Therapeutics for Giant Papillary Conjunctivitis

Drugs for Giant Papillary Conjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved Phase 4 82034-46-6, 129260-79-3 444025 9865442
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Anti-Allergic Agents Phase 4
5 Antiemetics Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Autonomic Agents Phase 4
9 Gastrointestinal Agents Phase 4
10 glucocorticoids Phase 4
11 Hormone Antagonists Phase 4
12 Hormones Phase 4
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
14 Methylprednisolone acetate Phase 4
15 Methylprednisolone Hemisuccinate Phase 4
16 Neuroprotective Agents Phase 4
17 Peripheral Nervous System Agents Phase 4
18 Prednisolone acetate Phase 4
19 Prednisolone hemisuccinate Phase 4
20 Prednisolone phosphate Phase 4
21 Protective Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study to Evaluate the Safety and Efficacy of Lotemax Ophthalmic Suspension 0.5% Active, not recruiting NCT01437982 Phase 4 Loteprednol Etabonate;Prednisolone Acetate 1% Oph Susp

Search NIH Clinical Center for Giant Papillary Conjunctivitis

Genetic Tests for Giant Papillary Conjunctivitis

Anatomical Context for Giant Papillary Conjunctivitis

MalaCards organs/tissues related to Giant Papillary Conjunctivitis:

41
Eye, Neutrophil

Publications for Giant Papillary Conjunctivitis

Articles related to Giant Papillary Conjunctivitis:

(show top 50) (show all 100)
# Title Authors Year
1
Surgical treatment outcome of medically refractory huge giant papillary conjunctivitis. ( 29260110 )
2017
2
Tacrolimus ointment 0.03% in the eye for treatment of giant papillary conjunctivitis. ( 18216583 )
2008
3
Filtering bleb-induced giant papillary conjunctivitis. ( 17826299 )
2008
4
Giant papillary conjunctivitis. ( 18769199 )
2008
5
Giant papillary conjunctivitis. ( 18282547 )
2008
6
Immunohistochemical findings in prosthesis-associated giant papillary conjunctivitis. ( 17760635 )
2007
7
M cells are involved in pathogenesis of human contact lens-associated giant papillary conjunctivitis. ( 17557145 )
2007
8
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. ( 16767372 )
2006
9
Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses. ( 15677951 )
2005
10
Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 14566648 )
2003
11
Contact lens chemistry and giant papillary conjunctivitis. ( 12772728 )
2003
12
Giant papillary conjunctivitis associated with an ocular prosthesis. ( 12366372 )
2001
13
Meibomian gland status and prevalence of giant papillary conjunctivitis in contact lens wearers. ( 15326900 )
2000
14
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study ( 10844086 )
2000
15
Giant papillary conjunctivitis in frequent-replacement contact lens wearers: a retrospective study. ( 10703125 )
1999
16
Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. ( 10410873 )
1999
17
Giant papillary conjunctivitis in frequent replacement contact lens wearers: a retrospective study. ( 10444049 )
1999
18
Giant papillary conjunctivitis--a review. ( 10337425 )
1999
19
Effect of lodoxamide on tear leukotriene levels in giant papillary conjunctivitis associated with ocular prosthesis. ( 9785608 )
1998
20
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. ( 9001768 )
1997
21
A double-masked, placebo-controlled evaluation of the efficacy and safety of loteprednol etabonate in the treatment of giant papillary conjunctivitis. The Loteprednol Etabonate Giant Papillary Conjunctivitis Study Group I. ( 9124242 )
1997
22
Increased numbers of Langerhans cell and expression of HLA-Dr antigen in the giant papilla of patients with giant papillary conjunctivitis. ( 8755197 )
1996
23
Contact lens type, material, and deposits and giant papillary conjunctivitis. ( 7712614 )
1995
24
Effect of extended wear disposable contact lenses on tear LTC4 in giant papillary conjunctivitis. ( 22827277 )
1995
25
Localised giant papillary conjunctivitis secondary to a dermolipoma. ( 7556754 )
1995
26
Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. ( 7586473 )
1995
27
Bilateral giant papillary conjunctivitis related to glaucoma drainage surgery blebs. ( 7995075 )
1994
28
Giant papillary conjunctivitis. ( 7886881 )
1994
29
Safety and efficacy of loteprednol etabonate for treatment of papillae in contact lens-associated giant papillary conjunctivitis. ( 8319490 )
1993
30
Causative factors in unilateral giant papillary conjunctivitis. ( 8495560 )
1993
31
Meibomian gland function and giant papillary conjunctivitis. ( 8420369 )
1993
32
Unusual causes of giant papillary conjunctivitis. ( 8458237 )
1993
33
N-acetyl-aspartyl glutamic acid (NAAGA) topical eyedrops in the treatment of giant papillary conjunctivitis (GPC). ( 7910133 )
1993
34
Comparison of the clinical performance of the Acuvue disposable contact lens and CSI lens in patients with giant papillary conjunctivitis. ( 8470716 )
1993
35
Meibomian gland function and giant papillary conjunctivitis. ( 8420368 )
1993
36
Daily enzyme cleaning for giant papillary conjunctivitis. ( 1498575 )
1992
37
Meibomian gland function and giant papillary conjunctivitis. ( 1642294 )
1992
38
Giant papillary conjunctivitis and meibomian gland dysfunction blepharitis. ( 1499122 )
1992
39
Treatment of giant papillary conjunctivitis with cromolyn sodium. ( 1559288 )
1992
40
Evaluation of tear protein deposits on contact lenses from patients with and without giant papillary conjunctivitis. ( 1499118 )
1992
41
Continued contact lens wear in patients with giant papillary conjunctivitis. ( 1904798 )
1991
42
Neutrophil chemotactic factors in the tears of giant papillary conjunctivitis patients. ( 1846131 )
1991
43
Immunoglobulin deposition on soft contact lenses: relationship to hydrogel structure and mode of use and giant papillary conjunctivitis. ( 2407379 )
1990
44
Eosinophil granule major basic protein in contact lenses of patients with giant papillary conjunctivitis. ( 2199092 )
1990
45
Giant papillary conjunctivitis. ( 2193971 )
1990
46
Giant papillary conjunctivitis associated with elevated corneal deposits. ( 1706653 )
1990
47
Human conjunctival mast cells: distribution of MCT and MCTC in vernal conjunctivitis and giant papillary conjunctivitis. ( 2196302 )
1990
48
Association of giant papillary conjunctivitis with seasonal allergies. ( 2320363 )
1990
49
Some unusual nonallergic causes of giant papillary conjunctivitis. ( 2095029 )
1990
50
Protein and elemental analysis of contact lenses of patients with superior limbic keratoconjunctivitis or giant papillary conjunctivitis. ( 2717140 )
1989

Variations for Giant Papillary Conjunctivitis

Expression for Giant Papillary Conjunctivitis

Search GEO for disease gene expression data for Giant Papillary Conjunctivitis.

Pathways for Giant Papillary Conjunctivitis

Pathways related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.48 CCL11 CXCL8 IL11 IL4 LTF RNASE3
2
Show member pathways
13.11 CCL11 CXCL8 IL11 IL4
3
Show member pathways
13 CCL11 CXCL8 IL11 IL4
4
Show member pathways
12.96 CCL11 CXCL8 IL11 IL4
5
Show member pathways
12.89 CCL11 CXCL8 IL11 IL4
6
Show member pathways
12.36 CCL11 CXCL8 IL4 RNASE3
7
Show member pathways
12.23 CXCL8 IL11 IL4
8
Show member pathways
11.88 CCL11 CXCL8 IL4
9 11.59 IL11 IL4
10 11.55 CXCL8 IL11
11 11.5 CXCL8 IL4
12 11.49 CCL11 CXCL8 IL4
13
Show member pathways
11.47 CCL11 CXCL8 IL11 IL4
14
Show member pathways
11.45 CXCL8 IL4
15 11.34 CCL11 IL4
16 11.2 CXCL8 IL4
17 11.17 CCL11 CXCL8
18 11.14 CCL11 IL4
19
Show member pathways
11.14 CCL11 CXCL8 IL11 IL4
20 10.93 CCL11 CXCL8 IL4
21 10.91 IL11 IL4

GO Terms for Giant Papillary Conjunctivitis

Cellular components related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL11 CXCL8 IL11 IL4 LTF RNASE3
2 extracellular space GO:0005615 9.1 CCL11 CXCL8 IL11 IL4 LTF RNASE3

Biological processes related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.69 CCL11 CXCL8 IL4
2 defense response to Gram-negative bacterium GO:0050829 9.52 LTF RNASE3
3 cellular response to interleukin-1 GO:0071347 9.49 CCL11 CXCL8
4 chemokine-mediated signaling pathway GO:0070098 9.48 CCL11 CXCL8
5 B cell differentiation GO:0030183 9.46 IL11 IL4
6 neutrophil chemotaxis GO:0030593 9.43 CCL11 CXCL8
7 antimicrobial humoral response GO:0019730 9.4 LTF RNASE3
8 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.37 LTF RNASE3
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.32 IL11 IL4
10 antibacterial humoral response GO:0019731 9.26 LTF RNASE3
11 regulation of signaling receptor activity GO:0010469 9.26 CCL11 CXCL8 IL11 IL4
12 innate immune response in mucosa GO:0002227 9.16 LTF RNASE3
13 cytokine-mediated signaling pathway GO:0019221 8.92 CCL11 CXCL8 IL11 IL4

Molecular functions related to Giant Papillary Conjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.16 CCL11 CXCL8
2 lipopolysaccharide binding GO:0001530 8.96 LTF RNASE3
3 cytokine activity GO:0005125 8.92 CCL11 CXCL8 IL11 IL4

Sources for Giant Papillary Conjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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