Aliases & Classifications for Giardiasis

MalaCards integrated aliases for Giardiasis:

Name: Giardiasis 12 76 55 3 44 15 73
Infection by Giardia Lamblia 12
Beaver Feaver 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10718
ICD10 33 A07.1
ICD9CM 35 007.1
MeSH 44 D005873
UMLS 73 C0017536

Summaries for Giardiasis

CDC : 3 Giardia is a microscopic parasite that causes the diarrheal illness known as giardiasis. Giardia (also known as Giardia intestinalis, Giardia lamblia, or Giardia duodenalis) is found on surfaces or in soil, food, or water that has been contaminated with feces (poop) from infected humans or animals.

MalaCards based summary : Giardiasis, also known as infection by giardia lamblia, is related to strongyloidiasis and cryptosporidiosis, and has symptoms including fever and pruritus. An important gene associated with Giardiasis is CD79A (CD79a Molecule), and among its related pathways/superpathways are Apoptosis and Autophagy and Primary immunodeficiency. The drugs Azithromycin and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and liver.

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.

Wikipedia : 76 Giardiasis, popularly known as beaver fever, is a parasitic disease caused by Giardia lamblia. About 10%... more...

Related Diseases for Giardiasis

Diseases related to Giardiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 strongyloidiasis 30.7 CD79A TGFB1
2 cryptosporidiosis 30.6 CD40LG CD79A
3 cryofibrinogenemia 29.8 CD40LG CD79A
4 immunoglobulin a deficiency 1 29.7 CD40LG CD79A
5 coccidiosis 29.6 CD40LG CD79A
6 granulomatous hepatitis 29.4 CD40LG CD79A
7 celiac disease 1 29.4 CD40LG CD79A GZMB
8 gastrointestinal system disease 29.4 CD40LG CD79A SCT
9 b cell deficiency 29.0 CD40LG CD79A
10 clonorchiasis 10.7 CD79A TGFB1
11 rapidly progressive glomerulonephritis 10.7 CD79A TGFB1
12 fibromuscular dysplasia 10.6 MYLK TGFB1
13 orbit lymphoma 10.6 GZMB TIA1
14 lichen sclerosus et atrophicus 10.6 GZMB TIA1
15 lymphomatoid granulomatosis 10.6 GZMB TIA1
16 lymphocytic gastritis 10.6 GZMB TIA1
17 subcutaneous panniculitis-like t-cell lymphoma 10.6 GZMB TIA1
18 primary cutaneous anaplastic large cell lymphoma 10.6 GZMB TIA1
19 natural killer cell leukemia 10.6 GZMB TIA1
20 composite lymphoma 10.6 GZMB TIA1
21 hepatosplenic t-cell lymphoma 10.6 GZMB TIA1
22 lymphomatoid papulosis 10.6 GZMB TIA1
23 choriocarcinoma of the testis 10.6 GZMB TIA1
24 gingival disease 10.6 CD79A TGFB1
25 erythema multiforme 10.5 CD79A GZMB
26 infiltrating lipoma 10.5 GZMB TIA1
27 paranasal sinus disease 10.5 CD79A TGFB1
28 necrotizing sialometaplasia 10.5 GZMB TIA1
29 ocular cicatricial pemphigoid 10.5 CD79A TGFB1
30 panniculitis 10.4 GZMB TIA1
31 sialolithiasis 10.3 GZMB TGFB1
32 selective igg deficiency disease 10.3 CD40LG CD79A
33 c1q nephropathy 10.3 CD40LG CD79A
34 meningovascular neurosyphilis 10.3 CD40LG CD79A
35 alpha chain disease 10.2 CD40LG CD79A
36 brill-zinsser disease 10.2 CD40LG CD79A
37 exudative glomerulonephritis 10.2 CD40LG CD79A
38 cork-handlers' disease 10.2 CD40LG CD79A
39 viral esophagitis 10.2 CD79A GZMB TIA1
40 salpingo-oophoritis 10.2 CD40LG CD79A
41 early yaws 10.2 CD40LG CD79A
42 ventilation pneumonitis 10.2 CD40LG CD79A
43 chronic interstitial cystitis 10.2 CD40LG CD79A
44 axillary adenitis 10.2 CD40LG CD79A
45 trichostrongyloidiasis 10.2 CD40LG CD79A
46 subacute bacterial endocarditis 10.2 CD40LG CD79A
47 heterophyiasis 10.2 CD40LG CD79A
48 immunoglobulin g deficiency 10.2 CD40LG CD79A
49 orbital granuloma 10.2 CD40LG CD79A
50 transient hypogammaglobulinemia of infancy 10.2 CD40LG CD79A

Graphical network of the top 20 diseases related to Giardiasis:



Diseases related to Giardiasis

Symptoms & Phenotypes for Giardiasis

UMLS symptoms related to Giardiasis:


fever, pruritus

Drugs & Therapeutics for Giardiasis

Drugs for Giardiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 447043
2
Metronidazole Approved Phase 4,Phase 2,Not Applicable 443-48-1 4173
3
Tinidazole Approved, Investigational Phase 4 19387-91-8 5479
4 Anti-Bacterial Agents Phase 4,Phase 2
5 Antibiotics, Antitubercular Phase 4,Phase 2
6 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
7 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Not Applicable
8 Antiprotozoal Agents Phase 4,Phase 2,Not Applicable
9 Alkylating Agents Phase 4
10
Lactulose Approved Phase 2, Phase 3 4618-18-2 11333
11
Nitazoxanide Approved, Investigational, Vet_approved Phase 2, Phase 3 55981-09-4 41684
12 Gastrointestinal Agents Phase 2, Phase 3
13
Auranofin Approved, Investigational Phase 2 34031-32-8 6333901 6918453
14
Ceftriaxone Approved Phase 2 73384-59-5 5479530 5361919
15 Antirheumatic Agents Phase 2
16 Liver Extracts Phase 2
17
Iron Approved Not Applicable 7439-89-6 23925
18
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
19
Methadone Approved 76-99-3 4095
20
Formaldehyde Approved, Vet_approved 50-00-0 712
21
Secnidazole Approved Not Applicable 3366-95-8
22
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
23 Antibodies ,Not Applicable
24 Immunoglobulins ,Not Applicable
25 Ether
26 Retinol palmitate Not Applicable
27 Micronutrients Not Applicable
28 Trace Elements Not Applicable
29 Disinfectants ,Not Applicable
30 Anthelmintics Not Applicable
31 Vitamins Not Applicable
32 Antimitotic Agents Not Applicable
33 Vaccines
34 retinol Nutraceutical Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Giardia Induced Fatigue and Functional Gastrointestinal Diseases Completed NCT00860236 Phase 4
2 Mortality Reduction After Oral Azithromycin: Morbidity Study Completed NCT02048007 Phase 4 Azithromycin;Placebo
3 Treatment of Giardia Lamblia Infections in Children Recruiting NCT02942485 Phase 4 Metronidazole;Tinidazole
4 Nitazoxanide Plus Lactulose Versus Lactulose Alone Treatment of Hepatic Encephalopathy Recruiting NCT02464124 Phase 2, Phase 3 Nitazoxanide;Lactulose
5 Clinical Trial of the Reprofiled Drug Auranofin for GI Protozoa Recruiting NCT02736968 Phase 2 Auranofin
6 Optimising Antibiotic Treatment for Sick Malnourished Children Active, not recruiting NCT02746276 Phase 2 Ceftriaxone;Metronidazole
7 300 Antibody Diagnostic Test Kit Unknown status NCT01646411
8 Impact of Anti-Giardia and Antihelmintic Treatment on Infant Growth in Bangladesh Completed NCT00607074 Not Applicable Anti-Giardia and antihelmintic treatment (secnidazole or albendazole);Anti-Giardia treatment only (secnidazole or albendazole);Control group (placebo)
9 Malabsorption as a Cause of Iron Treatment Failure in Infants Completed NCT00456729 Not Applicable Metronidazole
10 Surveillance and Medical Help for HIV-infected Intravenous Drug Users in and Out of Prison Completed NCT00739258
11 Fecal Transplantation in Patients With IBS Completed NCT03333291 Not Applicable
12 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
13 Normative State and Variation in Growth, Hematology, Hydration, Oxidation, Infection, Inflammation, Guatemalan Children Completed NCT02203890
14 WASH Benefits Kenya Completed NCT01704105 Not Applicable
15 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
16 SaniVac Trial - Sanitation and Oral Rotavirus Vaccine Performance Recruiting NCT03313128
17 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297
18 The Effect of an Urban Sanitation Intervention on Child Health Recruiting NCT02362932 Not Applicable
19 The Safe Start Trial - Kisumu, Kenya Recruiting NCT03468114 Not Applicable
20 WASH Benefits Bangladesh Active, not recruiting NCT01590095 Not Applicable
21 Effectiveness of Point-of-use Water Treatment Technologies to Prevent Stunting Among Children in South Africa Active, not recruiting NCT03012048 Not Applicable
22 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Giardiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: giardiasis

Genetic Tests for Giardiasis

Anatomical Context for Giardiasis

MalaCards organs/tissues related to Giardiasis:

41
Small Intestine, Testes, Liver, Pancreas, Skin, Colon, Bone

Publications for Giardiasis

Articles related to Giardiasis:

(show top 50) (show all 605)
# Title Authors Year
1
Why Are Patients With Giardiasis Not Treated Earlier? Two Sides of the Same Coin. ( 29596575 )
2018
2
The course of experimental giardiasis in Mongolian gerbil. ( 29797082 )
2018
3
Giardiasis: Serum antibodies and coproantigens in brown rats (<i>Rattus norvegicus</i>) from Grenada, West Indies. ( 29657419 )
2018
4
Irritable Bowel Syndrome with predominant diarrhea and giardiasis: is it one or the other? ( 29500067 )
2018
5
Secnidazole for control of giardiasis in dairy calves. ( 29684664 )
2018
6
Giardiasis: a diagnosis that should be considered regardless of the setting. ( 29886858 )
2018
7
Giardiasis and subsequent diagnosis of HIV infection in a patient with persistent diarrhoea: a case report. ( 29525804 )
2018
8
Beaver Fever: Whole-Genome Characterization of Waterborne Outbreak and Sporadic Isolates To Study the Zoonotic Transmission of Giardiasis. ( 29695621 )
2018
9
Intestinal Giardiasis Disguised as Ulcerative Colitis. ( 29854495 )
2018
10
Under-reporting giardiasis; Time to consider the public health implications - ERRATUM. ( 29352816 )
2018
11
Giardiasis as a neglected disease in Brazil: Systematic review of 20 years of publications. ( 29065126 )
2017
12
Stimulated and Unstimulated Saliva Levels of Calcium and Magnesium in Giardiasis. ( 28111708 )
2017
13
Giardiasis Diagnosis and Treatment Practices Among Commercially Insured Persons in the United States. ( 28207070 )
2017
14
Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome. ( 28129747 )
2017
15
The influence of serial fecal sampling on the diagnosis of giardiasis in humans, dogs, and cats. ( 28902297 )
2017
16
Antigiardial Effect of Kramecyne in Experimental Giardiasis. ( 29387130 )
2017
17
Prophylactic Potential of Synbiotic (Lactobacillus casei and Inulin) in Malnourished Murine Giardiasis: an Immunological and Ultrastructural Study. ( 29260483 )
2017
18
Incidental giardiasis diagnosed during transduodenal EUS-FNA. ( 28713065 )
2017
19
The Intersection of Immune Responses, Microbiota, and Pathogenesis in Giardiasis. ( 28830665 )
2017
20
Diffuse Nodular Lymphoid Hyperplasia of the Intestine Caused by Common Variable Immunodeficiency and Refractory Giardiasis. ( 28154271 )
2017
21
Giardiasis and Subsequent Irritable Bowel Syndrome: A Longitudinal Cohort Study Using Health Insurance Data. ( 28329069 )
2017
22
Foodborne giardiasis: Is there any relationship between food handlers and transmission of Giardia duodenalis? ( 28079004 )
2017
23
Giardiasis Treatment Challenges in a Pediatric International Adoption Clinic. ( 28056536 )
2017
24
Significance of Nitric Oxide Level in Giardiasis. ( 28164484 )
2017
25
A novel inA vitro image-based assay identifies new drug leads for giardiasis. ( 28171818 )
2017
26
Under-reporting giardiasis: time to consider the public health implications. ( 28879824 )
2017
27
TLR2<sup>-/-</sup>Mice Display Decreased Severity of Giardiasis<i>via</i>Enhanced Proinflammatory Cytokines Production Dependent on AKT Signal Pathway. ( 28979269 )
2017
28
Giardia's primitive GPL biosynthesis pathways with parasitic adaptation 'patches': implications for Giardia's evolutionary history and for finding targets against Giardiasis. ( 28842650 )
2017
29
Spontaneous Resolution of Pancreatic Cyst After Treatment for Giardiasis. ( 28085756 )
2017
30
Giardiasis Outbreak Associated with Asymptomatic Food Handlers in New York State, 2015. ( 28402185 )
2017
31
Could the Fight Against Treatment Failures in Giardiasis Lead to a Second Childhood for Quinacrine? ( 28973255 )
2017
32
Associations between extreme precipitation and acute gastro-intestinal illness due to cryptosporidiosis and giardiasis in an urban Canadian drinking water system (1997-2009). ( 29215354 )
2017
33
Nitroimidazole-refractory giardiasis: a growing problem requiring rational solutions. ( 28624613 )
2017
34
Comparative efficacy of drugs for treating giardiasis: a systematic update of the literature and network meta-analysis of randomized clinical trials. ( 29186570 )
2017
35
Giardiasis mimicking celiac disease in a patient of common variable immunodeficiency. ( 29114494 )
2017
36
A Prospective Longitudinal Cohort to Investigate the Effects of Early Life Giardiasis on Growth and All Cause Diarrhea. ( 27313261 )
2016
37
Demonstration of Trophozoites of G. Lamblia in Ileal Mucosal Biopsy Specimens May Reveal Giardiasis in Patients With Significantly Inflamed Parasite-free Duodenal Mucosa. ( 27186850 )
2016
38
Molecular detection of giardiasis among children at Cairo University Pediatrics Hospitals. ( 27876969 )
2016
39
Giardiasis in NSW: Identification of Giardia duodenalis assemblages contributing to human and cattle cases, and an epidemiological assessment of sporadic human giardiasis. ( 27370572 )
2016
40
Adaptive immune response in symptomatic and asymptomatic enteric protozoal infection: evidence for a determining role of parasite genetic heterogeneity in host immunity to human giardiasis. ( 27401766 )
2016
41
Control of Giardiasis by Interleukin-17 in Humans and Mice--Are the Questions All Answered? ( 26581888 )
2016
42
Evolution of Socioeconomic Conditions and Its Relation to Spatial-Temporal Changes of Giardiasis and Helminthiasis in Amazonian Children. ( 27638472 )
2016
43
Giardiasis outbreaks in the United States, 1971-2011. ( 26750152 )
2016
44
An up-date on Giardia and giardiasis. ( 27501461 )
2016
45
Postinfectious and sporadic functional gastrointestinal disorders have different prevalences and rates of overlap: results from a controlled cohort study 3 years after acute giardiasis. ( 27189227 )
2016
46
Combination therapy in the management of giardiasis: What laboratory and clinical studies tell us, so far. ( 27349189 )
2016
47
Sequelae of giardiasis: an emerging public health concern. ( 27312579 )
2016
48
Giardiasis in the United States - an epidemiologic and geospatial analysis of county-level drinking water and sanitation data, 1993-2010. ( 27105412 )
2016
49
Introducing nitazoxanide as a promising alternative treatment for symptomatic to metronidazole-resistant giardiasis in clinical isolates. ( 27633304 )
2016
50
An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda. ( 27864517 )
2016

Variations for Giardiasis

Expression for Giardiasis

Search GEO for disease gene expression data for Giardiasis.

Pathways for Giardiasis

Pathways related to Giardiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.07 CD40LG GZMB TIA1
2 10.52 CD40LG CD79A

GO Terms for Giardiasis

Biological processes related to Giardiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glycolytic process GO:0006096 9.16 ENO1 TPI1
2 B cell proliferation GO:0042100 8.96 CD40LG CD79A
3 canonical glycolysis GO:0061621 8.62 ENO1 TPI1

Sources for Giardiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....