MCID: GRD001
MIFTS: 42

Giardiasis

Categories: Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Giardiasis

MalaCards integrated aliases for Giardiasis:

Name: Giardiasis 12 76 55 3 44 15 73
Infection by Giardia Lamblia 12
Beaver Feaver 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10718
ICD10 33 A07.1
ICD9CM 35 007.1
MeSH 44 D005873
SNOMED-CT 68 10679007 58265007
UMLS 73 C0017536

Summaries for Giardiasis

CDC : 3 Giardia is a microscopic parasite that causes the diarrheal illness known as giardiasis. Giardia (also known as Giardia intestinalis, Giardia lamblia, or Giardia duodenalis) is found on surfaces or in soil, food, or water that has been contaminated with feces (poop) from infected humans or animals.

MalaCards based summary : Giardiasis, also known as infection by giardia lamblia, is related to cryptosporidiosis and strongyloidiasis, and has symptoms including fever and pruritus. An important gene associated with Giardiasis is TPI1 (Triosephosphate Isomerase 1). The drugs Metronidazole and Tinidazole have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and liver.

Disease Ontology : 12 A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting.

Wikipedia : 76 Giardiasis, popularly known as beaver fever, is a parasitic disease caused by Giardia lamblia. About 10%... more...

Related Diseases for Giardiasis

Diseases related to Giardiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 cryptosporidiosis 30.8 TPI1 CD79A
2 strongyloidiasis 30.0 TGFB1 CD79A
3 diarrhea 10.3
4 orbit lymphoma 10.2 TIA1 GZMB
5 lymphomatoid granulomatosis 10.2 TIA1 GZMB
6 amebiasis 10.2
7 lichen sclerosus et atrophicus 10.2 TIA1 GZMB
8 lymphocytic gastritis 10.2 TIA1 GZMB
9 primary cutaneous anaplastic large cell lymphoma 10.2 TIA1 GZMB
10 subcutaneous panniculitis-like t-cell lymphoma 10.2 TIA1 GZMB
11 panniculitis 10.2 TIA1 GZMB
12 composite lymphoma 10.2 TIA1 GZMB
13 hepatosplenic t-cell lymphoma 10.2 TIA1 GZMB
14 lymphomatoid papulosis 10.1 TIA1 GZMB
15 choriocarcinoma of the testis 10.1 TIA1 GZMB
16 natural killer cell leukemia 10.1 TIA1 GZMB
17 infiltrating lipoma 10.1 TIA1 GZMB
18 common variable immunodeficiency 10.1
19 necrotizing sialometaplasia 10.1 TIA1 GZMB
20 lung lymphoma 10.1 GZMB CD79A
21 clonorchiasis 10.1 TGFB1 CD79A
22 lymphatic system cancer 10.1 TIA1 CD79A
23 fibromuscular dysplasia 10.1 TGFB1 MYLK
24 ileum cancer 10.1 TIA1 GZMB
25 celiac disease 1 10.1
26 iron metabolism disease 10.1
27 irritable bowel syndrome 10.1
28 pustulosis palmaris et plantaris 10.1 TGFB1 CD79A
29 angioimmunoblastic t-cell lymphoma 10.1 TIA1 GZMB
30 viral esophagitis 10.0 TIA1 GZMB CD79A
31 reticulosarcoma 10.0 TIA1 GZMB
32 ocular cicatricial pemphigoid 10.0 TGFB1 CD79A
33 helicobacter pylori infection 10.0
34 protein-losing enteropathy 10.0
35 urticaria 10.0
36 b-cell expansion with nfkb and t-cell anergy 10.0 TIA1 GZMB
37 cystic fibrosis 10.0
38 deficiency anemia 10.0
39 iron deficiency anemia 10.0
40 trichomoniasis 10.0
41 chronic fatigue syndrome 10.0
42 iga glomerulonephritis 10.0 TGFB1 CD79A
43 peripheral t-cell lymphoma 9.9 TIA1 GZMB
44 pancreatic cancer 9.9
45 agammaglobulinemia, x-linked 9.9
46 crohn's disease 9.9
47 ulcerative colitis 9.9
48 colitis 9.9
49 schistosomiasis 9.9
50 hypothyroidism 9.9

Graphical network of the top 20 diseases related to Giardiasis:



Diseases related to Giardiasis

Symptoms & Phenotypes for Giardiasis

UMLS symptoms related to Giardiasis:


fever, pruritus

Drugs & Therapeutics for Giardiasis

Drugs for Giardiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved Phase 4,Phase 2,Not Applicable 443-48-1 4173
2
Tinidazole Approved, Investigational Phase 4 19387-91-8 5479
3
Azithromycin Approved Phase 4 83905-01-5 55185 447043
4 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
5 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Not Applicable
6 Antiprotozoal Agents Phase 4,Phase 2,Not Applicable
7 Alkylating Agents Phase 4
8 Antibiotics, Antitubercular Phase 4,Phase 2
9 Anti-Bacterial Agents Phase 4,Phase 2
10
Lactulose Approved Phase 2, Phase 3 4618-18-2 11333
11
Nitazoxanide Approved, Investigational, Vet_approved Phase 2, Phase 3 55981-09-4 41684
12 Gastrointestinal Agents Phase 2, Phase 3
13
Auranofin Approved, Investigational Phase 2 34031-32-8 6333901 6918453
14
Ceftriaxone Approved Phase 2 73384-59-5 5479530 5361919
15 Antirheumatic Agents Phase 2
16 Liver Extracts Phase 2
17
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
18
Secnidazole Approved Not Applicable 3366-95-8
19
Iron Approved Not Applicable 7439-89-6 23925
20
Methadone Approved 76-99-3 4095
21
Formaldehyde Approved, Vet_approved 50-00-0 712
22
Iodine Approved, Investigational 7553-56-2 807
23
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
24 Immunologic Factors
25 Immunoglobulins ,Not Applicable
26 Antibodies ,Not Applicable
27 Anthelmintics Not Applicable
28 Antimitotic Agents Not Applicable
29 Disinfectants ,Not Applicable
30 Ether
31 Vitamins Not Applicable
32 Retinol palmitate Not Applicable
33 retinol Not Applicable
34 Micronutrients Not Applicable
35 Trace Elements Not Applicable
36 cadexomer iodine
37 Vaccines

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Giardia Induced Fatigue and Functional Gastrointestinal Diseases Completed NCT00860236 Phase 4
2 Treatment of Giardia Lamblia Infections in Children Recruiting NCT02942485 Phase 4 Metronidazole;Tinidazole
3 Mortality Reduction After Oral Azithromycin: Morbidity Study Enrolling by invitation NCT02048007 Phase 4 Azithromycin;Placebo
4 Nitazoxanide Plus Lactulose Versus Lactulose Alone Treatment of Hepatic Encephalopathy Recruiting NCT02464124 Phase 2, Phase 3 Nitazoxanide;Lactulose
5 Clinical Trial of the Reprofiled Drug Auranofin for GI Protozoa Recruiting NCT02736968 Phase 2 Auranofin
6 Optimising Antibiotic Treatment for Sick Malnourished Children Active, not recruiting NCT02746276 Phase 2 Ceftriaxone;Metronidazole
7 300 Antibody Diagnostic Test Kit Unknown status NCT01646411
8 Impact of Anti-Giardia and Antihelmintic Treatment on Infant Growth in Bangladesh Completed NCT00607074 Not Applicable Anti-Giardia and antihelmintic treatment (secnidazole or albendazole);Anti-Giardia treatment only (secnidazole or albendazole);Control group (placebo)
9 Malabsorption as a Cause of Iron Treatment Failure in Infants Completed NCT00456729 Not Applicable Metronidazole
10 Surveillance and Medical Help for HIV-infected Intravenous Drug Users in and Out of Prison Completed NCT00739258
11 Fecal Transplantation in Patients With IBS Completed NCT03333291 Not Applicable
12 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
13 Normative State and Variation in Growth, Hematology, Hydration, Oxidation, Infection, Inflammation, Guatemalan Children Completed NCT02203890
14 WASH Benefits Kenya Completed NCT01704105 Not Applicable
15 Intestinal Parasites in Inhabitants of Kuyavian-Pomeranian Province in Poland Recruiting NCT03490435
16 SaniVac Trial - Sanitation and Oral Rotavirus Vaccine Performance Recruiting NCT03313128
17 Epidemiology of Chronic Diarrhea Among Children Admitted to Gastroenterology Unit at Assuit University Children Hospital Recruiting NCT03261297
18 The Effect of an Urban Sanitation Intervention on Child Health Recruiting NCT02362932 Not Applicable
19 The Safe Start Trial - Kisumu, Kenya Recruiting NCT03468114 Not Applicable
20 WASH Benefits Bangladesh Active, not recruiting NCT01590095 Not Applicable
21 Effectiveness of Point-of-use Water Treatment Technologies to Prevent Stunting Among Children in South Africa Active, not recruiting NCT03012048 Not Applicable
22 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Giardiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: giardiasis

Genetic Tests for Giardiasis

Anatomical Context for Giardiasis

MalaCards organs/tissues related to Giardiasis:

41
Small Intestine, Testes, Liver, T Cells, B Cells, Lung, Testis

Publications for Giardiasis

Articles related to Giardiasis:

(show top 50) (show all 1003)
# Title Authors Year
1
Why Are Patients With Giardiasis Not Treated Earlier? Two Sides of the Same Coin. ( 29596575 )
2018
2
The course of experimental giardiasis in Mongolian gerbil. ( 29797082 )
2018
3
Giardiasis: Serum antibodies and coproantigens in brown rats (<i>Rattus norvegicus</i>) from Grenada, West Indies. ( 29657419 )
2018
4
Irritable Bowel Syndrome with predominant diarrhea and giardiasis: is it one or the other? ( 29500067 )
2018
5
Secnidazole for control of giardiasis in dairy calves. ( 29684664 )
2018
6
Giardiasis: a diagnosis that should be considered regardless of the setting. ( 29886858 )
2018
7
Giardiasis and subsequent diagnosis of HIV infection in a patient with persistent diarrhoea: a case report. ( 29525804 )
2018
8
Beaver Fever: Whole-Genome Characterization of Waterborne Outbreak and Sporadic Isolates To Study the Zoonotic Transmission of Giardiasis. ( 29695621 )
2018
9
Intestinal Giardiasis Disguised as Ulcerative Colitis. ( 29854495 )
2018
10
Under-reporting giardiasis; Time to consider the public health implications - ERRATUM. ( 29352816 )
2018
11
Rapid diagnostic tests relying on antigen detection from stool as an efficient point of care testing strategy for giardiasis and cryptosporidiosis? Evaluation of a new immunochromatographic duplex assay. ( 30122511 )
2018
12
A spatial analysis of giardiasis and cryptosporidiosis in relation to public water supply distribution in North West England. ( 30409377 )
2018
13
Methodological innovations for the study of irreplaceable samples reveal giardiasis in extinct animals (Nothrotherium maquinense and Palaeolama maior). ( 30053542 )
2018
14
A natural zoonotic giardiasis: Infection of a child via Giardia cysts in pet chinchilla droppings. ( 30053544 )
2018
15
Efficacy of mebendazole in paediatric patients with giardiasis: A systematic review and meta-analysis. ( 30092225 )
2018
16
Effect of probiotic Saccharomyces boulardii in experimental giardiasis. ( 30165752 )
2018
17
Epidemiology and associated risk factors of giardiasis in a peri-urban setting in New South Wales Australia. ( 30264685 )
2018
18
Giardiasis: characteristics, pathogenesis and new insights about treatment. ( 30277155 )
2018
19
The Influence of Climate and Livestock Reservoirs on Human Cases of Giardiasis. ( 30350000 )
2018
20
Genetics and serology of celiac disease during giardiasis. ( 30353768 )
2018
21
Activity of Thioallyl Compounds From Garlic Against Giardia duodenalis Trophozoites and in Experimental Giardiasis. ( 30374433 )
2018
22
A Rare Complication of Giardiasis in Children: Protein-losing Enteropathy. ( 30408010 )
2018
23
Treatment-refractory giardiasis: challenges and solutions. ( 30498364 )
2018
24
Treatment of refractory paediatric giardiasis using secnidazole plus albendazole: a case series. ( 30555145 )
2018
25
Giardiasis as a neglected disease in Brazil: Systematic review of 20 years of publications. ( 29065126 )
2017
26
Stimulated and Unstimulated Saliva Levels of Calcium and Magnesium in Giardiasis. ( 28111708 )
2017
27
Giardiasis Diagnosis and Treatment Practices Among Commercially Insured Persons in the United States. ( 28207070 )
2017
28
Giardia-specific cellular immune responses in post-giardiasis chronic fatigue syndrome. ( 28129747 )
2017
29
The influence of serial fecal sampling on the diagnosis of giardiasis in humans, dogs, and cats. ( 28902297 )
2017
30
Antigiardial Effect of Kramecyne in Experimental Giardiasis. ( 29387130 )
2017
31
Prophylactic Potential of Synbiotic (Lactobacillus casei and Inulin) in Malnourished Murine Giardiasis: an Immunological and Ultrastructural Study. ( 29260483 )
2017
32
Incidental giardiasis diagnosed during transduodenal EUS-FNA. ( 28713065 )
2017
33
The Intersection of Immune Responses, Microbiota, and Pathogenesis in Giardiasis. ( 28830665 )
2017
34
Diffuse Nodular Lymphoid Hyperplasia of the Intestine Caused by Common Variable Immunodeficiency and Refractory Giardiasis. ( 28154271 )
2017
35
Giardiasis and Subsequent Irritable Bowel Syndrome: A Longitudinal Cohort Study Using Health Insurance Data. ( 28329069 )
2017
36
Foodborne giardiasis: Is there any relationship between food handlers and transmission of Giardia duodenalis? ( 28079004 )
2017
37
Giardiasis Treatment Challenges in a Pediatric International Adoption Clinic. ( 28056536 )
2017
38
Significance of Nitric Oxide Level in Giardiasis. ( 28164484 )
2017
39
A novel inA vitro image-based assay identifies new drug leads for giardiasis. ( 28171818 )
2017
40
Under-reporting giardiasis: time to consider the public health implications. ( 28879824 )
2017
41
TLR2<sup>-/-</sup>Mice Display Decreased Severity of Giardiasis<i>via</i>Enhanced Proinflammatory Cytokines Production Dependent on AKT Signal Pathway. ( 28979269 )
2017
42
Giardia's primitive GPL biosynthesis pathways with parasitic adaptation 'patches': implications for Giardia's evolutionary history and for finding targets against Giardiasis. ( 28842650 )
2017
43
Spontaneous Resolution of Pancreatic Cyst After Treatment for Giardiasis. ( 28085756 )
2017
44
Giardiasis Outbreak Associated with Asymptomatic Food Handlers in New York State, 2015. ( 28402185 )
2017
45
Could the Fight Against Treatment Failures in Giardiasis Lead to a Second Childhood for Quinacrine? ( 28973255 )
2017
46
Associations between extreme precipitation and acute gastro-intestinal illness due to cryptosporidiosis and giardiasis in an urban Canadian drinking water system (1997-2009). ( 29215354 )
2017
47
Nitroimidazole-refractory giardiasis: a growing problem requiring rational solutions. ( 28624613 )
2017
48
Giardiasis mimicking celiac disease in a patient of common variable immunodeficiency. ( 29114494 )
2017
49
Erratum to: Stimulated and Unstimulated Saliva Levels of Calcium and Magnesium in Giardiasis. ( 28243850 )
2017
50
Comparative efficacy of drugs for treating giardiasis: a systematic update of the literature and network meta-analysis of randomized clinical trials. ( 29186570 )
2017

Variations for Giardiasis

Expression for Giardiasis

Search GEO for disease gene expression data for Giardiasis.

Pathways for Giardiasis

GO Terms for Giardiasis

Biological processes related to Giardiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gluconeogenesis GO:0006094 9.16 ENO1 TPI1
2 glycolytic process GO:0006096 8.96 ENO1 TPI1
3 canonical glycolysis GO:0061621 8.62 ENO1 TPI1

Molecular functions related to Giardiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 8.92 CD79A ENO1 SOHLH2 TGFB1

Sources for Giardiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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