Aliases & Classifications for Gigantism

MalaCards integrated aliases for Gigantism:

Name: Gigantism 53 55 73

Classifications:



External Ids:

UMLS 73 C0017547

Summaries for Gigantism

NIH Rare Diseases : 53 Gigantism is abnormally large growth due to an excess of growth hormone (GH) during childhood, before the bone growth plates have closed (epiphyseal fusion). It causes excessive growth in height, muscles, and organs, making the child extremely large for his or her age. Other symptoms may include delayed puberty; double vision or difficulty with side (peripheral) vision; prominent forehead (frontal bossing) and a prominent jaw; headache; increased sweating (hyperhidrosis); irregular periods; large hands and feet with thick fingers and toes; thickening of the facial features; and weakness. It may begin at any age before epiphyseal fusion. The most common cause is a non-cancerous (benign) tumor of the pituitary gland, which may cause it to make too much GH, but it can be caused by other underlying conditions (which may cause a pituitary tumor) including Carney complex; McCune-Albright syndrome ; Multiple endocrine neoplasia type 1 (MEN-1) and type 4; and Neurofibromatosis. In some cases the disease is caused by mutations in the GPR101 gene. Treatment typically includes surgery to remove the tumor and can cure many cases. Medication or radiation therapy may be used to reduce GH release or block the effect of GH.  If the condition occurs after normal bone growth has stopped (in adulthood), it is referred to as acromegaly.

MalaCards based summary : Gigantism is related to pituitary adenoma 1, multiple types and mccune-albright syndrome, and has symptoms including endocrine system signs and symptoms An important gene associated with Gigantism is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways is Growth hormone receptor signaling. The drugs lanreotide and Somatostatin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and breast.

Wikipedia : 76 Gigantism, also known as giantism (from Greek γίγας gigas, \"giant\", plural γίγαντες gigantes), is a... more...

Related Diseases for Gigantism

Diseases related to Gigantism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 pituitary adenoma 1, multiple types 31.4 AIP GH1 PRL
2 mccune-albright syndrome 31.3 GH1 PRL
3 dwarfism 29.8 GH1 GHRH
4 acromegaly 29.4 AIP GH1 GHRH GPR101 PRL
5 fibrous dysplasia 29.3 GH1 PRL
6 hyperprolactinemia 29.1 GH1 PRL
7 growth hormone secreting pituitary adenoma 29.0 AIP PRL
8 pituitary apoplexy 28.8 AIP PRL
9 adenoma 28.8 AIP GH1 PRL
10 hypopituitarism 28.8 GH1 GHRH PRL
11 insulin-like growth factor i 28.7 GH1 GHRH PRL
12 pituitary tumors 28.2 AIP GH1 PRL
13 multiple endocrine neoplasia, type i 28.0 GHRH PRL
14 pituitary adenoma, prolactin-secreting 28.0 AIP GH1 PRL
15 cerebral gigantism jaw cysts 12.2
16 sotos syndrome 1 12.0
17 gigantism advanced bone age hoarse cry 11.9
18 perlman syndrome 11.9
19 beckwith-wiedemann syndrome 11.8
20 chromosome xq26.3 duplication syndrome 11.7
21 simpson-golabi-behmel syndrome, type 1 11.6
22 simpson-golabi-behmel syndrome 11.5
23 proteus syndrome 11.4
24 x-linked acrogigantism due to a point mutation 11.2
25 lipodystrophy, congenital generalized, type 2 11.1
26 cowden syndrome 1 10.8
27 simpson-golabi-behmel syndrome, type 2 10.8
28 pituitary adenoma 2, growth hormone-secreting 10.8
29 lipodystrophy, congenital generalized, type 1 10.8
30 macrocephaly mesodermal hamartoma spectrum 10.8
31 cerebritis 10.5
32 isolated growth hormone deficiency, type ib 10.2 GH1 GHRH
33 isolated growth hormone deficiency, type ii 10.2 GH1 GHRH
34 isolated growth hormone deficiency 10.1 GH1 GHRH
35 macroglossia 10.1
36 pituitary adenoma 10.0
37 growth hormone deficiency 10.0 GH1 GHRH
38 carney complex variant 10.0 AIP GPR101
39 sella turcica neoplasm 9.9 GHRH PRL
40 tuberculum sellae meningioma 9.9 GHRH PRL
41 wilms tumor 5 9.9
42 wilms tumor 6 9.9
43 lymphoma 9.8
44 tuberous sclerosis 9.8
45 lipomatosis 9.8
46 renal dysplasia 9.8
47 pituitary-dependent cushing's disease 9.8 GHRH PRL
48 fibrous dysplasia/mccune-albright syndrome 9.8 GH1 PRL
49 tsh producing pituitary tumor 9.8 GH1 PRL
50 adenohypophysitis 9.8 GH1 PRL

Graphical network of the top 20 diseases related to Gigantism:



Diseases related to Gigantism

Symptoms & Phenotypes for Gigantism

UMLS symptoms related to Gigantism:


endocrine system signs and symptoms

Drugs & Therapeutics for Gigantism

Drugs for Gigantism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 lanreotide Approved Phase 4 108736-35-2
2
Somatostatin Approved, Investigational Phase 4 38916-34-6, 51110-01-1 53481605
3 Hormone Antagonists Phase 4,Phase 2
4 Hormones Phase 4,Phase 2
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
6 Angiopeptin Phase 4
7 Liver Extracts Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Pilot Study of Pre- and Post-operative Use of Somatuline Depot. Terminated NCT01861717 Phase 4 lanreotide
2 Efficacy and Safety of Pasireotide LAR in Japanese Patients With Acromegaly or Pituitary Gigantism Completed NCT01673646 Phase 2 SOM230LAR
3 Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools Unknown status NCT01775332 Not Applicable
4 Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA Recruiting NCT00461188

Search NIH Clinical Center for Gigantism

Genetic Tests for Gigantism

Anatomical Context for Gigantism

MalaCards organs/tissues related to Gigantism:

41
Pituitary, Bone, Breast, Liver, Hypothalamus, Colon, B Cells

Publications for Gigantism

Articles related to Gigantism:

(show top 50) (show all 487)
# Title Authors Year
1
Deep Invasive Fungal Infection of the Hand in a Child Mimicking a Local Gigantism. ( 29706736 )
2018
2
Submucosal tunneling endoscopic resection of a gigantic cardiac leiomyoma. ( 29901859 )
2018
3
A Gigantic Anal Mass: Buschke-LAPwenstein Tumor in a Patient with Controlled HIV Infection with Fatal Outcome. ( 29808133 )
2018
4
Dental Management of a Young Child Affected by Galactosialidosis and a Gigantic Abdominal Growth. ( 29808128 )
2018
5
The evolution of foraging capacity and gigantism in cetaceans. ( 29895582 )
2018
6
An orphan G-protein-coupled receptor causes human gigantism and/or acromegaly: Molecular biology and clinical correlations. ( 29678281 )
2018
7
Surgical trauma induces overgrowth in lower limb gigantism: regulation with use of rapamycin is promising. ( 29301794 )
2018
8
Gigantism Precedes Filter Feeding in Baleen Whale Evolution. ( 29754903 )
2018
9
Unusual <i>AIP</i> mutation and phenocopy in the family of a young patient with acromegalic gigantism. ( 29472986 )
2018
10
Oldest case of gigantism? Assessment of the alleged remains of Sa-Nakht, king of ancient Egypt. ( 28732663 )
2017
11
Independent evolution of baleen whale gigantism linked to Plio-Pleistocene ocean dynamics. ( 28539520 )
2017
12
Earth's oldest 'Bobbit worm' - gigantism in a Devonian eunicidan polychaete. ( 28220886 )
2017
13
AIP mutations and gigantism. ( 28483363 )
2017
14
Regional endothermy as a trigger for gigantism in some extinct macropredatory sharks. ( 28938002 )
2017
15
Multiple organ gigantism caused by mutation in VmPPD gene in blackgram (Vigna mungo). ( 28588392 )
2017
16
In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism. ( 28634279 )
2017
17
Efficacy and safety of long-acting pasireotide in Japanese patients with acromegaly or pituitary gigantism: results from a multicenter, open-label, randomized, phase 2 study. ( 28592706 )
2017
18
Submucosal tunneling endoscopic resection of a gigantic esophageal leiomyoma. ( 28946172 )
2017
19
Tyrannosauroid integument reveals conflicting patterns of gigantism and feather evolution. ( 28592520 )
2017
20
A Paleocene penguin from New Zealand substantiates multiple origins of gigantism in fossil Sphenisciformes. ( 29233963 )
2017
21
Corrigendum: Gigantism and comparative life-history parameters of tyrannosaurid dinosaurs. ( 26675726 )
2016
22
Bilateral gigantic earlobe keloids. ( 26833527 )
2016
23
Gigantism: X-linked acrogigantism and GPR101 mutations. ( 27743704 )
2016
24
Multiple origins of gigantism in stem baleen whales. ( 27717969 )
2016
25
Genetic drift and mutational hazard in the evolution of salamander genomic gigantism. ( 27714793 )
2016
26
Increased Population Risk of AIP-related Acromegaly and Gigantism in Ireland. ( 27650164 )
2016
27
Combined treatment with octreotide LAR and pegvisomant in patients with pituitary gigantism: clinical evaluation and genetic screening. ( 27287035 )
2016
28
Gigantic vascular anomaly in a PHACE syndrome patient managed with photodynamic therapy. ( 27229363 )
2016
29
Gigantism and Its Implications for the History of Life. ( 26771527 )
2016
30
Pituitary gigantism: a retrospective case series. ( 26887033 )
2016
31
Coexisting diseases modifying each othera89s presentation - lack of growth failure in Turner syndrome due to the associated pituitary gigantism. ( 29328563 )
2016
32
Genetics of gigantism and acromegaly. ( 27657986 )
2016
33
Gigantic Suprapubic Lymphedema: A Case Study. ( 27574599 )
2016
34
Aggressive tumor growth and clinical evolution in a patient with X-linked acro-gigantism syndrome. ( 26607152 )
2016
35
Benign or Malignant? Two Case Reports of Gigantic Prostatic Cyst. ( 27500085 )
2016
36
Giants among larges: how gigantism impacts giant virus entry into amoebae. ( 27039270 )
2016
37
A rare case of Acro-gigantism. ( 27728208 )
2016
38
Salamanders' slow slither into genomic gigantism(). ( 27861781 )
2016
39
Macrodystrophia Lipomatosa: An Unusual Cause of Localized Gigantism. ( 27293271 )
2016
40
Convergent evolution of sperm gigantism and the developmental origins of sperm size variability in Caenorhabditis nematodes. ( 27565121 )
2016
41
Localized gigantism. ( 25987124 )
2015
42
Pituitary gigantism: update on molecular biology and management. ( 26574647 )
2015
43
Pituitary gigantism: Causes and clinical characteristics. ( 26585365 )
2015
44
Ecological explanations to island gigantism: dietary niche divergence, predation, and size in an endemic lizard. ( 26405734 )
2015
45
Gigantism Remains a Clinical Challenge. ( 26621024 )
2015
46
The Oldest Recorded Case of Acromegaly and Gigantism in Iran. ( 26443258 )
2015
47
Gigantism, acromegaly, and GPR101 mutations. ( 25806920 )
2015
48
Gigantism, acromegaly, and GPR101 mutations. ( 25806919 )
2015
49
Pituitary Gigantism - Experience of a Single Centre from Western India. ( 25716640 )
2015
50
Localised gigantism. ( 25849020 )
2015

Variations for Gigantism

Expression for Gigantism

Search GEO for disease gene expression data for Gigantism.

Pathways for Gigantism

Pathways related to Gigantism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.24 GH1 PRL

GO Terms for Gigantism

Cellular components related to Gigantism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 GH1 GHRH GPC3 PRL
2 endosome lumen GO:0031904 8.62 GH1 PRL

Biological processes related to Gigantism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.54 GH1 GHRH PRL
2 response to nutrient levels GO:0031667 9.32 GH1 PRL
3 positive regulation of multicellular organism growth GO:0040018 9.26 GH1 GHRH
4 positive regulation of JAK-STAT cascade GO:0046427 9.16 GH1 PRL
5 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.96 GH1 PRL
6 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.62 GH1 GHRH

Molecular functions related to Gigantism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 GH1 PRL
2 prolactin receptor binding GO:0005148 8.62 GH1 PRL

Sources for Gigantism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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