MCID: GGN004
MIFTS: 25

Gigantomastia

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Gigantomastia

MalaCards integrated aliases for Gigantomastia:

Name: Gigantomastia 52
Gestational Gigantomastia 52 71
Medication-Induced Gigantomastia 52
Pregnancy-Induced Gigantomastia 52
Puberty-Induced Gigantomastia 52
Pubertal Breast Hypertrophy 71
Drug-Induced Gigantomastia 52
Idiopathic Gigantomastia 52
Juvenile Gigantomastia 52
Macromastia 52

Classifications:



External Ids:

UMLS 71 C0405471 C2936844

Summaries for Gigantomastia

NIH Rare Diseases : 52 Gigantomastia is a rare condition characterized by excessive breast growth. It may occur spontaneously, during puberty or pregnancy, or while taking certain medications. There is no universally accepted definition of gigantomastia, but the majority of medical articles refer to a particular weight of excess breast tissue . Symptoms of gigantomastic may include mastalgia (breast pain), ulceration/infection, posture problems, back pain and chronic traction injury to 4th/5th/6th intercostal nerves with resultant loss of nipple sensation. It is also associated with decreased fetal growth, if it occurs during pregnancy. The exact cause of gigantomastia is not known; however, hormonal and hereditary factors may be involved. Additionally, gigantomastia has been noted as a side effect of treatment with certain medications, such as like D-penicillamine. Treatment may include breast reduction, mastectomy with or without reconstruction, hormonal treatment, or a combination of treatments.

MalaCards based summary : Gigantomastia, also known as gestational gigantomastia, is related to hypertrophy of the breast, juvenile and hypertrophy of breast. The drugs Acetylcholine and Neurotransmitter Agents have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and kidney.

Wikipedia : 74 Breast hypertrophy is a rare medical condition of the breast connective tissues in which the breasts... more...

Related Diseases for Gigantomastia

Diseases related to Gigantomastia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 hypertrophy of the breast, juvenile 12.1
2 hypertrophy of breast 11.6
3 aromatase excess syndrome 11.2
4 ptosis 10.4
5 allergic hypersensitivity disease 10.4
6 breast fibroadenoma 10.3
7 pseudoangiomatous stromal hyperplasia 10.3
8 gynecomastia 10.2
9 hypertrichosis 10.2
10 autoimmune disease 10.2
11 systemic lupus erythematosus 10.2
12 carpal tunnel syndrome 10.1
13 hypertrichosis lanuginosa congenita 10.1
14 infant gynecomastia 10.1
15 eating disorder 10.1
16 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.1
17 myasthenia gravis 10.1
18 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
19 hyperprolactinemia 10.1
20 angiosarcoma 10.1
21 lymphoma 10.1
22 scoliosis 10.1
23 mastitis 10.1
24 lupus erythematosus 10.1
25 alagille syndrome 1 10.0
26 hashimoto thyroiditis 10.0
27 poland syndrome 10.0
28 schizophrenia 10.0
29 thymoma, familial 10.0
30 bulimia nervosa 10.0
31 congenital hypothyroidism 10.0
32 exanthem 10.0
33 squamous cell papilloma 10.0
34 hypothyroidism 10.0
35 intraductal papilloma 10.0
36 hyperinsulinism 10.0
37 papilloma 10.0
38 lobular neoplasia 10.0
39 thymoma 10.0
40 thymic carcinoma 10.0
41 breast disease 10.0
42 lung disease 10.0
43 in situ carcinoma 10.0
44 carcinoma showing thymus-like differentiation 10.0
45 lymphangiomatosis 10.0
46 symmastia 10.0
47 inflammatory myopathy with abundant macrophages 10.0
48 breast cancer 10.0
49 lipomatosis, multiple 10.0
50 facioscapulohumeral muscular dystrophy 1 10.0

Graphical network of the top 20 diseases related to Gigantomastia:



Diseases related to Gigantomastia

Symptoms & Phenotypes for Gigantomastia

Drugs & Therapeutics for Gigantomastia

Drugs for Gigantomastia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 2, Phase 3 51-84-3 187
2 Neurotransmitter Agents Phase 2, Phase 3
3 abobotulinumtoxinA Phase 2, Phase 3
4 Acetylcholine Release Inhibitors Phase 2, Phase 3
5 Cholinergic Agents Phase 2, Phase 3
6 Botulinum Toxins, Type A Phase 2, Phase 3
7 Botulinum Toxins Phase 2, Phase 3

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Multi-centre Study to Show Equivalence of Prineo (DERMABOND PROTAPE) to Intradermal Sutures for Skin Closure of Full-thickness Surgical Incisions Associated With Breast Procedures Completed NCT00558246 Phase 4
2 The Efficacy and Molecular Mechanism of Botulinum Toxin in the Reduction of Breast Reduction Mammoplasty Scar Formation: A Prospective, Controlled, Randomized, Double-blinded Study Not yet recruiting NCT03887377 Phase 2, Phase 3 Botulinum Toxins;Normal saline
3 The Difference in Presentation Level of Variant Receptors in Female Breast Tissue in Macromastia and Micromastia Unknown status NCT00173251 Phase 1
4 Reduction Mammaplasty Safely Increases the Quality of Life in Patients With Mammary Hypetrophy. Completed NCT02769559
5 Weight Loss by Low Energy Diet as Treatment Prior Mamma Reduction in Overweight Women - A Pilot Study Completed NCT02659371
6 Sexuality and Depression Predictors Among Breast Hypertrophy Women Undergoing Reduction Mammaplasty Completed NCT01020422
7 Characterization and Implication of Prolactin Receptor Mutants in Human Breast Diseases Completed NCT00842465
8 Superomedial Pedicle Versus Inferior Pedicle in Breast Reduction Surgery Completed NCT03669679
9 Twenty-four Hours or 6 Days? A Prospective Randomized Trial Comparing Dressing Wear Time After Reduction Mammaplasty Completed NCT01002391
10 A Prospective, Randomized, Controlled Study to Evaluate Use of the PEAK PlasmaBlade 4.0 in Bilateral Breast Reduction Completed NCT00986453
11 A Prospective, Randomized, Controlled Study to Evaluate Cutaneous Scar Quality Following Bilateral Breast Reduction With the PEAK PlasmaBlade 4.0 Terminated NCT01284491
12 An Observational Study Exploring the Esthetic Outcomes of Breast Reduction Surgery and /or Mastopexy Terminated NCT02016677
13 A Prospective, Randomized, Controlled Superiority Study to Evaluate Use of the PEAK PlasmaBlade® 4.0 in Bilateral Breast Reduction Withdrawn NCT01404351

Search NIH Clinical Center for Gigantomastia

Genetic Tests for Gigantomastia

Anatomical Context for Gigantomastia

MalaCards organs/tissues related to Gigantomastia:

40
Breast, Skin, Kidney, B Cells

Publications for Gigantomastia

Articles related to Gigantomastia:

(show top 50) (show all 207)
# Title Authors PMID Year
1
Redefining gigantomastia. 52 61
20965141 2011
2
Gigantomastia--a classification and review of the literature. 61 52
18054304 2008
3
Idiopathic gigantomastia: newer mechanistic insights implicating the paracrine milieu. 61
31502211 2019
4
Response to Letter to the Editor: "Gestational Gigantomastia Complicated by PTHrP-Mediated Hypercalcemia". 61
30977835 2019
5
Supero-Septum Pedicle Mammaplasty: A New Modification for Reduction Mammaplasty. 61
31745547 2019
6
Batwing mammoplasty: a safe oncoplastic technique for breast conservation in breast cancer patients with gigantomastia. 61
31538808 2019
7
[Oncoplasty by the Thorek technique for lower quadrant cancers in a condition of gigantomastia]. 61
31386918 2019
8
A Rare Case of Persistent Unilateral Gestational Gigantomastia. 61
31592388 2019
9
Inferior and Central Mound Pedicle Breast Reduction in Gigantomastia: A Safe Alternative? 61
31405319 2019
10
The medial-central septum based mammaplasty: A reliable technique to preserve nipple-areola complex sensitivity in post bariatric patients. 61
31077504 2019
11
A rare case of gestational gigantomastia. 61
29316177 2019
12
Letter to the Editor: "Gestational Gigantomastia Complicated by PTHrP-Mediated Hypercalcemia". 61
30541082 2019
13
Gestational Gigantomastia in the Setting of Myasthenia Gravis. 61
30956501 2019
14
Gestational gigantomastia. 61
30389173 2019
15
Breast Reduction Using the Superomedial Pedicle- and Septal Perforator-Based Technique: Our Clinical Experience. 61
29948104 2019
16
Prednisolone-induced virginal mammary hypertrophy: Case report. 61
31146195 2019
17
The Place of Reductive Surgery in the Management of Gestational Ulcerative Gigantomastia: A Case Report at Sourô Sanou Teaching Hospital. 61
31236302 2019
18
[A case of bilateral gestational gigantomastia]. 61
31143355 2019
19
Gestational Gigantomastia Complicated by PTHrP-Mediated Hypercalcemia. 61
30032172 2018
20
Supero-medial reduction mammaplasty: a safe and reliable technique in gigantomastia and severe breast ptosis. 61
30214706 2018
21
The Evolution of Breast Reduction Publications: A Bibliometric Analysis. 61
29352346 2018
22
Gestational gigantomastia complicated with deep vein thrombosis 61
30064186 2018
23
Extreme gigantomastia. 61
29157631 2018
24
[How I do…for the surgical management of gestational gigantomastia]. 61
29776839 2018
25
Resolution Of Gestational Gigantomastia With Termination Of Pregnancy. 61
29938441 2018
26
Concurrent giant tumoral pseudoangiomatous stromal hyperplasia necessitating bilateral mastectomy. 61
29536962 2018
27
In Pursuit of Effective Volume Reduction and Enhanced Aesthetics for Treatment of Gigantomastia Using Superior Dermoglandular Pedicle. 61
29340749 2018
28
Gestational gigantomastia with spontaneous resolution in an Indian woman. 61
29592998 2018
29
Combining Breast Reduction Techniques to Treat Gigantomastia in Ghana. 61
29616171 2018
30
Treatment of Gigantomastia Using a Medial-Lateral Bipedicle Reduction Mammoplasty: The Role of Doppler-Assisted Preoperative Perforator Identification. 61
29273932 2018
31
[Ribeiro-Technique in Gigantomastia - Review of 294 Reduction Mammaplasties in 8 Years]. 61
28763811 2017
32
A journey through liposuction and liposculture: Review. 61
29158895 2017
33
Gestational gigantomastia in systemic lupus erythematosus. 61
29272260 2017
34
The Classic Pitanguy Technique and Its Modifications in Mammaplasty: Ten Years of Experiences. 61
28650403 2017
35
Septum-Enhanced Mammaplasty in Inferocentral Pedicled Breast Reduction for Macromastia and Gigantomastia Patients. 61
28374304 2017
36
Pregnancy-associated gigantomastia recurrence and ectopic breast after reduction mammaplasty: A case report. 61
28869443 2017
37
Management of Gigantomastia: Outcomes of Superomedial Pedicle with Vertical Scar or Wise Pattern Skin Excision. 61
28713712 2017
38
Septum-Inferior-Medial (SIM)-Based Pedicle: A Safe Pedicle with Well-Preserved Nipple Sensation for Reduction in Gigantomastia. 61
28032174 2017
39
Gestational Gigantomastia: A Case Report. 61
29927570 2017
40
Gestational Gigantomastia: A Systematic Review of Case Reports. 61
28458479 2017
41
A case of gestational gigantomastia in a 37-years-old woman associated with elevated ANA: a casual linkage? 61
28904695 2017
42
Gigantomastia due to retromammary lipoma: An aesthetic management. 61
28598828 2017
43
[Polymastia in unusual localization during pregnancy]. 61
28537415 2017
44
Macromastia and gigantomastia: efficacy of the superomedial pedicle pattern for breast reduction surgery. 61
28272856 2016
45
Bilateral Diffuse Pseudoangiomatous Stromal Hyperplasia (PASH) Causing Gigantomastia in a 33-Year-Old Pregnant Woman: Case Report. 61
27920630 2016
46
A Rare Case of Gestational Gigantomastia with Hypercalcemia: The Challenges of Management and Follow up. 61
27921004 2016
47
Bilateral Gigantomastia, Multiple Synchronous Nodular Pseudoangiomatous Stromal Hyperplasia Involving Breast and Bilateral Axillary Accessory Breast Tissue, and Perianal Mammary-Type Hamartoma of Anogenital Mammary-Like Glands: A Case Report. 61
26863057 2016
48
Central Pedicle Reduction in Gigantomastia Without Free Nipple Graft. 61
26954750 2016
49
Gestational Gigantomastia. 61
28331740 2016
50
Avoiding Complications in Gigantomastia. 61
27012802 2016

Variations for Gigantomastia

Expression for Gigantomastia

Search GEO for disease gene expression data for Gigantomastia.

Pathways for Gigantomastia

GO Terms for Gigantomastia

Sources for Gigantomastia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....