Gilbert Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GLB001 MIFTS: 56	Gilbert Syndrome Categories: Genetic diseases, Rare diseases, Metabolic diseases, Liver diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Download Expand all tables

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Aliases & Classifications for Gilbert Syndrome

MalaCards integrated aliases for Gilbert Syndrome:

Name: Gilbert Syndrome ⁵⁷ ¹² ⁵³ ²⁵ ⁷⁵ ³⁷ ¹⁵

Gilbert's Syndrome ¹² ⁷⁶ ²⁵ ²⁹ ⁶ ⁴⁰

Gilbert's Disease ¹² ⁵³ ²⁵

Gilbert Disease ²⁵ ⁴⁴ ⁷³

Gilbert Syndrome, Susceptibility to ²⁹ ⁶

Hyperbilirubinemia, Gilbert Type; Hblrg ⁵⁷

Constitutional Hyperbilirubinemia ¹²

Unconjugated Benign Bilirubinemia ²⁵

Hyperbilirubinemia, Gilbert Type ⁵⁷

Hereditary Nonhemolytic Jaundice ¹²

Constitutional Liver Dysfunction ²⁵

Hyperbilirubinemia, Arias Type ⁵⁷

Familial Nonhemolytic Jaundice ²⁵

Gilbert-Meulengracht Syndrome ¹²

Hyperbilirubinemia Arias Type ⁵³

Gilbert-Lereboullet Syndrome ²⁵

Hyperbilirubinemia Type 1 ⁵³

Meulengracht Syndrome ²⁵

Hyperbilirubinemia I ⁵⁷

Hyperbilirubinemia 1 ²⁵

Cholemia, Familial ⁵³

Gilberts Syndrome ⁵⁵

Hblrg ⁵⁷

Gilbs ⁷⁵

Characteristics:

OMIM:

⁵⁷

Inheritance:
autosomal recessive

Miscellaneous:
common (up to 7% of the population)
rarely produces clinical jaundice
decreased bilirubin concentration with phenobarbital administration
does not lead to hepatic failure

HPO:

³²

gilbert syndrome:
Inheritance autosomal recessive inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Metabolic diseases
Anatomical: Liver diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Endocrine, nutritional and metabolic diseases

Metabolic disorders

Disorders of porphyrin and bilirubin metabolism

Gilbert syndrome

External Ids:

OMIM ⁵⁷ 143500

Disease Ontology ¹² DOID:2739

ICD10 ³³ E80.4

MeSH ⁴⁴ D005878

NCIt ⁵⁰ C84729

SNOMED-CT ⁶⁸ 154770008 267509000 27503000

MedGen ⁴² C0017551

KEGG ³⁷ H02055

SNOMED-CT via HPO ⁶⁹ 258211005 18165001 7752002

UMLS ⁷³ C0017551

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Summaries for Gilbert Syndrome

Genetics Home Reference : ²⁵ Gilbert syndrome is a relatively mild condition characterized by periods of elevated levels of a toxic substance called bilirubin in the blood (hyperbilirubinemia). Bilirubin, which has an orange-yellow tint, is produced when red blood cells are broken down. This substance is removed from the body only after it undergoes a chemical reaction in the liver, which converts the toxic form of bilirubin (unconjugated bilirubin) to a nontoxic form called conjugated bilirubin. People with Gilbert syndrome have a buildup of unconjugated bilirubin in their blood (unconjugated hyperbilirubinemia). In affected individuals, bilirubin levels fluctuate and very rarely increase to levels that cause jaundice, which is yellowing of the skin and whites of the eyes.

MalaCards based summary : Gilbert Syndrome, also known as gilbert's syndrome, is related to cholelithiasis and crigler-najjar syndrome, type i. An important gene associated with Gilbert Syndrome is UGT1A1 (UDP Glucuronosyltransferase Family 1 Member A1), and among its related pathways/superpathways are Porphyrin and chlorophyll metabolism and Metabolism. The drugs Ritonavir and Zinc have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and eye, and related phenotypes are jaundice and unconjugated hyperbilirubinemia

OMIM : ⁵⁷ The hereditary hyperbilirubinemias (Wolkoff et al., 1983) include (1) those resulting in predominantly unconjugated hyperbilirubinemia: Gilbert or Arias syndrome, Crigler-Najjar syndrome type I (218800), and Crigler-Najjar syndrome type II (606785); and (2) those resulting in predominantly conjugated hyperbilirubinemia: Dubin-Johnson syndrome (237500), Rotor syndrome (237450), and several forms of intrahepatic cholestasis (147480, 211600, 214950, 243300). Detailed studies show that patients with Gilbert syndrome have reduced activity of bilirubin glucuronosyltransferase (Bosma et al., 1995, Koiwai et al., 1995). (143500)

UniProtKB/Swiss-Prot : ⁷⁵ Gilbert syndrome: Occurs as a consequence of reduced bilirubin transferase activity and is often detected in young adults with vague non-specific complaints.

NIH Rare Diseases : ⁵³ Gilbert syndrome is a common, mild liver disorder in which the liver doesn't properly process bilirubin, a substance produced by the breakdown of red blood cells. Gilbert syndrome typically doesn't require treatment or pose serious complications. In fact, Gilbert syndrome is usually not considered a disease because of its benign nature. Many individuals find out they have the disorder by accident, when they have a blood test that shows elevated bilirubin levels. More males than females have been diagnosed with Gilbert syndrome. This condition is caused by mutations in the UGT1A1 gene and is inherited in an autosomal recessive pattern.

Disease Ontology : ¹² A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin as bilirubin is not being conjugated as a result of reduced glucuronyltransferase activity.

Wikipedia : ⁷⁶ Gilbert\'s syndrome (GS) is a mild liver disorder in which the liver does not properly process... more...

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Related Diseases for Gilbert Syndrome

Diseases related to Gilbert Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)

#	Related Disease	Score	Top Affiliating Genes
1	cholelithiasis	29.9	UGT1A1 UGT1A6
2	crigler-najjar syndrome, type i	29.1	UGT1A1 UGT1A4 UGT1A6 UGT1A9
3	neonatal jaundice	28.5	G6PD SLCO1B1 UGT1A1
4	kernicterus	28.3	G6PD UGT1A1 UGT1A4 UGT1A6 UGT1A9
5	crigler-najjar syndrome, type ii	25.7	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
6	mental retardation with spastic paraplegia and palmoplantar hyperkeratosis	11.1
7	congenital nonhemolytic jaundice	11.0
8	anemia, congenital dyserythropoietic, type iii	10.9
9	hyperbilirubinemia, shunt, primary	10.9
10	descending colon cancer	10.2	UGT1A1 UGT1A6
11	dihydropyrimidine dehydrogenase deficiency	10.2	UGT1A1 UGT1A6
12	hereditary spherocytosis	10.1
13	sickle cell anemia	10.0	UGT1A1 UGT1A6
14	thalassemia	9.9
15	hypertrophic pyloric stenosis	9.9
16	pyloric stenosis	9.9
17	irinotecan toxicity	9.8	SLCO1B1 UGT1A1 UGT1A7
18	beta-thalassemia	9.8
19	inherited metabolic disorder	9.7	UGT1A1 UGT1A6
20	pigmentation disease	9.7	SLCO1B1 UGT1A1 UGT1A6
21	autism	9.7
22	cystic fibrosis	9.7
23	factor vii deficiency	9.7
24	hemochromatosis, type 1	9.7
25	alpha-thalassemia	9.7
26	aplastic anemia	9.7
27	kawasaki disease	9.7
28	leukemia, acute lymphoblastic	9.7
29	pulmonary fibrosis and/or bone marrow failure, telomere-related, 2	9.7
30	alacrima, achalasia, and mental retardation syndrome	9.7
31	hemolytic anemia	9.7
32	hepatitis	9.7
33	hepatitis b	9.7
34	ischemic heart disease	9.7
35	leukemia	9.7
36	ulcerative colitis	9.7
37	colitis	9.7
38	scoliosis	9.7
39	lymphoblastic leukemia	9.7
40	heart disease	9.7
41	choledocholithiasis	9.7
42	gaucher's disease	9.7
43	hemoglobinopathy	9.7
44	endotheliitis	9.7
45	glucosephosphate dehydrogenase deficiency	9.2	G6PD SLCO1B1 UGT1A1
46	pericholangitis	9.0	UGT1A10 UGT1A3 UGT1A4 UGT1A8
47	acetaminophen metabolism	8.8	UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9
48	bilirubin metabolic disorder	8.4	G6PD SLCO1B1 UGT1A1 UGT1A6 UGT1A7
49	bilirubin, serum level of, quantitative trait locus 1	7.3	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7

Graphical network of the top 20 diseases related to Gilbert Syndrome:

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Symptoms & Phenotypes for Gilbert Syndrome

Symptoms via clinical synopsis from OMIM:

⁵⁷

Laboratory Abnormalities:
decreased hepatic udp-glucuronyl-transferase activity
hyperbilirubinemia, non-hemolytic unconjugated (may rise with fasting or dehydration)
normal liver function test

Clinical features from OMIM:

143500

Human phenotypes related to Gilbert Syndrome:

³²

#	Description	HPO Frequency	HPO Source Accession
1	jaundice ³²		HP:0000952
2	unconjugated hyperbilirubinemia ³²		HP:0008282

GenomeRNAi Phenotypes related to Gilbert Syndrome according to GeneCards Suite gene sharing:

²⁶ (show all 11)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	9.5	UGT1A4
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-127	9.5	UGT1A3 UGT1A4
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-130	9.5	UGT1A7
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-138	9.5	UGT1A4
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-147	9.5	UGT1A3 UGT1A7
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-19	9.5	UGT1A7
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-21	9.5	UGT1A3 UGT1A4 UGT1A7
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-215	9.5	UGT1A3
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	9.5	UGT1A7
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-56	9.5	UGT1A7
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	9.5	UGT1A7

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Drugs & Therapeutics for Gilbert Syndrome

Drugs for Gilbert Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Ritonavir

Approved, Investigational

Phase 4

155213-67-5

392622

Zinc

Approved, Investigational

Phase 4

7440-66-6

23994

Zinc sulfate

Approved, Investigational

Phase 4

7733-02-0

Ursodeoxycholic acid

Approved, Investigational

Phase 4

128-13-2

31401

Anti-HIV Agents

Phase 4

Anti-Infective Agents

Phase 4

Anti-Retroviral Agents

Phase 4

Antiviral Agents

Phase 4

Astringents

Phase 4

Atazanavir Sulfate

Phase 4

Bilirubin

Phase 4

635-65-4

5280352

Cytochrome P-450 CYP3A Inhibitors

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Dermatologic Agents

Phase 4,Phase 3

HIV Protease Inhibitors

Phase 4

Micronutrients

Phase 4

protease inhibitors

Phase 4

Trace Elements

Phase 4

Cholagogues and Choleretics

Phase 4

Gastrointestinal Agents

Phase 4

N-Methylaspartate

Phase 4

alanine

Nutraceutical

Phase 4

Aspartic Acid

Nutraceutical

Phase 4

Methotrexate

Approved

Phase 3

1959-05-2, 59-05-2

126941

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 3

59-30-3

6037

leucovorin

Approved, Nutraceutical

Phase 3

58-05-9

143 6006

Antimetabolites

Phase 3

Antimetabolites, Antineoplastic

Phase 3

Antirheumatic Agents

Phase 3

Folic Acid Antagonists

Phase 3

Immunosuppressive Agents

Phase 3

Nucleic Acid Synthesis Inhibitors

Phase 3

Vitamin B Complex

Phase 3

Folate

Nutraceutical

Phase 3

Vitamin B9

Nutraceutical

Phase 3

Carboplatin

Approved

Phase 1, Phase 2

41575-94-4

10339178 498142 38904

Paclitaxel

Approved, Vet_approved

Phase 1, Phase 2

33069-62-4

36314

Lapatinib

Approved March 2007, Investigational

Phase 1, Phase 2

231277-92-2, 388082-78-8

208908 9941095

Albumin-Bound Paclitaxel

Phase 1, Phase 2

Antimitotic Agents

Phase 1, Phase 2

Antineoplastic Agents, Phytogenic

Phase 1, Phase 2

Protein Kinase Inhibitors

Phase 1, Phase 2

Pharmaceutical Solutions

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Atazanavir/Ritonavir and Zinc Pharmacokinetic Study	Completed	NCT01475227	Phase 4	1 Solvazinc tablet, day 2 to day 15;1 Solvazinc tablet, day 15 to day 28
2	The Role of Ursodeoxycholic Acid in Treatment of Gallstones in Hemolytic Disorders	Terminated	NCT02472509	Phase 4	Ursodeoxycholic Acid
3	A Study to Evaluate Efficacy of Tocilizumab Administered as Monotherapy or in Combination With Methotrexate and/or Other Disease Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis (RA) Participants	Completed	NCT01941940	Phase 3	Tocilizumab;DMARDs
4	Study Of White Blood Cells In The Cerebrospinal Fluid And Blood Of Patients With Relapsing Forms Of Multiple Sclerosis	Completed	NCT00469378	Phase 2	firategrast
5	Lapatinib With Carboplatin and Paclitaxel in Esophagus and Gastroesophageal Junction (GEJ)	Terminated	NCT01395537	Phase 1, Phase 2	Carboplatin AUC;Paclitaxel;lapatinib
6	Safety, Tolerability and Pharmacokinetics of Multiple Rising Doses of BI 201335 NA in Healthy Male Subjects	Completed	NCT02182362	Phase 1	BI 201335 NA;Placebo
7	Demographic, Metabolic, and Genomic Description of Neonates With Severe Hyperbilirubinemia	Completed	NCT00383318
8	Biomarker for Patients With Gilbert Disease	Recruiting	NCT02712138

Search NIH Clinical Center for Gilbert Syndrome

Cochrane evidence based reviews: gilbert disease

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Genetic Tests for Gilbert Syndrome

Genetic tests related to Gilbert Syndrome:

#	Genetic test	Affiliating Genes
1	Gilbert's Syndrome ²⁹	UGT1A1
2	Gilbert Syndrome, Susceptibility to ²⁹

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Anatomical Context for Gilbert Syndrome

MalaCards organs/tissues related to Gilbert Syndrome:

⁴¹

Liver, Skin, Eye, Testes, Heart, Breast, Endothelial

Sources

Publications for Gilbert Syndrome

Articles related to Gilbert Syndrome:

(show top 50) (show all 98)

#	Title	Authors	Year
1	Gilbert syndrome combined with prolonged jaundice caused by contrast agent: Case report. ( 29632429 )	Qian J.D....Wang G.Q.	2018
2	Frequency of the UGT1A1*28 Polymorphism in a Romanian Cohort of Gilbert Syndrome Individuals. ( 28338110 )	Radoi V.E....Bohiltea R.	2017
3	Mixed Dubin-Gilbert Syndrome: A Compound Heterozygous Phenotype of Two Novel Variants in ABCC2 Gene. ( 28397734 )	Jiang J....Peng X.X.	2017
4	Differences in UGT1A1 gene mutations and pathological liver changes between Chinese patients with Gilbert syndrome and Crigler-Najjar syndrome type II. ( 29137095 )	Sun L....Wang P.	2017
5	Gilbert Syndrome with Concomitant Hereditary Spherocytosis Presenting with Moderate Unconjugated Hyperbilirubinemia. ( 28321066 )	Aiso M....Takikawa H.	2017
6	Oncology Drug Dosing in Gilbert Syndrome Associated with UGT1A1: A Summary of the Literature. ( 28494109 )	Ha V.H....Tsang R.Y.	2017
7	Gilbert Syndrome ( 29262099 )	Thoguluva Chandrasekar V....John S.	2017
8	An Infant With Unusually High Unconjugated Hyperbilirubinemia Due to Coexistence of Hereditary Spherocytosis and Gilbert Syndrome. ( 29200157 )	Butorac Ahel I....Roganovic J.	2017
9	Gilbert syndrome in patients with type 1 diabetes-Prevalence, glycemic control, and microalbuminuria. ( 28093842 )	Singer S....Pinhas-Hamiel O.	2017
10	Disease-modifying influences of coexistent G6PD-deficiency, Gilbert syndrome and deletional alpha thalassemia in hereditary spherocytosis: A report of three cases. ( 27108201 )	Jamwal M....Das R.	2016
11	Effectiveness of switching from oral ziprasidone to risperidone in a patient with comorbid autistic disorder, profound intellectual disability, Gilbert syndrome, and exacerbation of psychosis. ( 26938829 )	Del Casale A....Girardi P.	2016
12	Scoliosis in a Patient With Gilbert Syndrome: A Case Report and Review of the Literature. ( 26632744 )	Li Z....Liang J.	2015
13	Protective effect of elevated bilirubin levels on cardiovascular disease in patients with Gilbert syndrome. ( 26536982 )	GA1rel E....Tigen M.K.	2015
14	Gilbert syndrome acts as a risk factor of developing gallstone among I^ hemoglobinopathy tunisian patients. ( 26375741 )	Chaouch L....Abbes S.	2015
15	Outcome and toxicities associated to chemotherapy in children with acute lymphoblastic leukemia and Gilbert syndrome. Usefulness of UGT1A1 mutational screening. ( 25855413 )	Berrueco R....Rives S.	2015
16	Donor Safety and Recipient Liver Function After Right-Lobe Liver Transplantation From Living Donors With Gilbert Syndrome. ( 26707296 )	Kang W.H....Lee S.G.	2015
17	Evaluation of aortic stiffness in Gilbert syndrome patients: a protective effect of elevated bilirubin levels. ( 26536984 )	YA1ce S....KA+zA+lkaya B.	2015
18	Genotype of UGT1A1 and phenotype correlation between Crigler-Najjar syndrome type II and Gilbert syndrome. ( 26250421 )	Maruo Y....Takeuchi Y.	2015
19	Patterns and genetic polymorphisms in unconjugated hyperbilirubinemia (gilbert syndrome). ( 25646240 )	Kamal S....Huda H.	2015
20	Relation between Neonatal Icter and Gilbert Syndrome in Gloucose-6-Phosphate Dehydrogenase Deficient Subjects. ( 24783083 )	Zahedpasha Y....Alaee E.	2014
21	Perfluorocarbons and Gilbert syndrome (phenotype) in the C8 Health Study Population. ( 25262077 )	Fan H....Zhang J.	2014
22	Coexistence of gilbert syndrome and hereditary spherocytosis in a child presenting with extreme jaundice. ( 25587528 )	Lee J.H....Moon K.R.	2014
23	Role of co-inherited Gilbert syndrome on hyperbilirubinemia in Indian beta thalassemia patients. ( 24620945 )	Dabke P.S....Nadkarni A.H.	2014
24	Pregnancy with gilbert syndrome - a case report. ( 25121033 )	Mohan M....Reddy P.V.	2014
25	Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome. ( 22773454 )	Maruhashi T....Higashi Y.	2012
26	Right-lobe liver transplant from donors with Gilbert syndrome. ( 22309418 )	Demirbas T....Yuzer Y.	2012
27	Coexistence of Gilbert syndrome with hereditary haemolytic anaemias. ( 22554963 )	Rawa K....Burzynska B.	2012
28	Association of a glucose-6-phosphate deficiency and a Gilbert syndrome as risk factors for a severe choledocholithiasis in a 2-month-old male infant. ( 21793186 )	Rivet C....Joly P.	2012
29	Gilbert syndrome redefined: a complex genetic haplotype influences the regulation of glucuronidation. ( 22213127 )	Ehmer U....Strassburg C.P.	2012
30	Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. ( 22521902 )	Boon A.C....Bulmer A.C.	2012
31	Impact of UGT1A1 gene variants on total bilirubin levels in Gilbert syndrome patients and in healthy subjects. ( 22325916 )	Rodrigues C....Bronze-da-Rocha E.	2012
32	Severe jaundice in two children with Kawasaki disease: a possible association with Gilbert syndrome. ( 22219623 )	Karpathios T....Fretzayas A.	2012
33	Gilbert syndrome. ( 22160004 )	Fretzayas A....Karpathios T.	2012
34	Gilbert syndrome increasing unconjugated hyperbilirubinemia in a child with hereditary spherocytosis. ( 22134611 )	Kumar D....Sharma S.	2012
35	Gilbert syndrome: the UGT1A1*28 promoter polymorphism as a biomarker of multifactorial diseases and drug metabolism. ( 22448797 )	Gil J....SA8siadek M.M.	2012
36	Diagnosis and treatment difficulties in 18-year-old male patient with hereditary hemochromatosis, chronic hepatitis B, Gilbert syndrome and ulcerative colitis. ( 21633730 )	Sikorska K....Bielawski K.P.	2011
37	Prevalence of Gilbert syndrome in parents of neonates with pathologic indirect hyperbilirubinemia. ( 21403409 )	Saki F....Haghighat M.	2011
38	Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab. ( 21412181 )	Lee J.S....Krasnow J.	2011
39	Snapback primer genotyping of the Gilbert syndrome UGT1A1 (TA)(n) promoter polymorphism by high-resolution melting. ( 21771946 )	Farrar J.S....Wittwer C.T.	2011
40	Is Gilbert syndrome a new risk factor for breast cancer? ( 21636218 )	Astolfi R.H....Baracat E.C.	2011
41	Gilbert syndrome in Iran, Fars Province. ( 20103965 )	Hemmati F....Haghighat M.	2010
42	Combined effect of regulatory polymorphisms on transcription of UGT1A1 as a cause of Gilbert syndrome. ( 20529348 )	Matsui K....Takeuchi Y.	2010
43	Gilbert syndrome as a predisposing factor for cholelithiasis risk in the Greek adult population. ( 19309288 )	Tsezou A....Kitsiou-Tzeli S.	2009
44	Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin. ( 18343383 )	Schwertner H.A....VA-tek L.	2008
45	''Iatrogenic Gilbert syndrome''--a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin. ( 17825497 )	McCarty M.F.	2007
46	Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes. ( 17895455 )	Inoguchi T....Yamada T.	2007
47	Severe hyperbilirubinemia in a 10-year-old girl with a combined disorder of hereditary spherocytosis and Gilbert syndrome. ( 17587286 )	Sugita K....Eguchi M.	2007
48	Urinary excretion of oxidative metabolites of bilirubin in subjects with Gilbert syndrome. ( 17565639 )	VA-tek L....Yamaguchi T.	2007
49	Gilbert syndrome presenting in a young boy, confirmed by the rifampin test. ( 17877076 )	Keren G....Mazilis A.	2007
50	Gilbert syndrome in the newborn. ( 17990369 )	Kaplan M....Hammerman C.	2007

Sources

Genes for Gilbert Syndrome

Genes related to Gilbert Syndrome (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	1045.54	Molecular basis known ⁵⁷ Causative variation ⁷⁵ Genetic Tests ²⁹ Typically genetic variations that lead to apparently abnormal laboratory test values ⁵⁷ Pathogenic ⁶ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)	11906189 15378351 1692835 (more) 7565971 8514037 9342374 9653159 9621515 9375768 9375769 9446675 10190918 10968441 11061796 11370628 12402338 12859413 11003624 15372086 11425418 12850492 16114182 15857854 17496722 19243019 10091406 7565971 12499798 12139570 17496722 10340924 11013440 10359058 10190918 11422622 9630669 14647407 11316168 11259359 18324905 15378351 11230743 11061796 16210851 16610035 15771689 15304120 10421657 11394668 12732365 12800608 15853761 16792515 16557566 17353700 18491077 18982743 19845429 20389299 8912353 9375768 10546817 10390262 11106326 10850406 18004206 17347060 17105600 16012956 11174102 11141380 11003624 16498946 14744740 12198827 11915038 11868392 11783956 10498597 9796407 18437170 16386929 15388579 11827650 10427468 9653159 18349289 17058217 15858133 15560369 12618960 19932091 19672597 17196409 15049432 12480553 10412811 19309288 19021734 17850628 16969497 15205079 11906189 11857560 11097345 10960450 9466980 9435989 9252066 20194756 16469709 15304109 12371080 10720749
2	UGT1A4	UDP Glucuronosyltransferase Family 1 Member A4	Protein Coding	44.82	Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications Variants (show sections)	12012638 1920916
3	UGT1A7	UDP Glucuronosyltransferase Family 1 Member A7	Protein Coding	43.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications Variants (show sections)	18349289 19303655 17850628
4	UGT1A6	UDP Glucuronosyltransferase Family 1 Member A6	Protein Coding	36.75	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
5	UGT1A3	UDP Glucuronosyltransferase Family 1 Member A3	Protein Coding	33.31	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
6	UGT1A9	UDP Glucuronosyltransferase Family 1 Member A9	Protein Coding	32.04	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
7	G6PD	Glucose-6-Phosphate Dehydrogenase	Protein Coding	26.16	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11803413 10091404 9342374 (more) 16166048 10359058 10541948 11114816 11787865 9375769 10192462 12368976 11277384 9724685 15686267 12680285 19324225 12208096
8	SLCO1B1	Solute Carrier Organic Anion Transporter Family Member 1B1	Protein Coding	23.68	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	UGT1A10	UDP Glucuronosyltransferase Family 1 Member A10	Protein Coding	23.33	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)
10	UGT1A8	UDP Glucuronosyltransferase Family 1 Member A8	Protein Coding	22.36	DISEASES inferred ¹⁵ GeneCards inferred via : Variants (show sections)

Sources

Variations for Gilbert Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Gilbert Syndrome:

⁷⁵

#	Symbol	AA change	Variation ID	SNP ID
1	UGT1A1	p.Tyr486Asp	VAR_007709	rs34993780
2	UGT1A1	p.Gly71Arg	VAR_009504	rs4148323
3	UGT1A1	p.Pro229Gln	VAR_009505	rs35350960
4	UGT1A1	p.Arg367Gly	VAR_012283	rs55750087
5	UGT1A1	p.Phe83Leu	VAR_026136	rs56059937
6	UGT1A1	p.Ile294Thr	VAR_026139	rs72551347

ClinVar genetic disease variations for Gilbert Syndrome:

⁶

(show all 30)

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	UGT1A1	NM_000463.2(UGT1A1): c.1021C> T (p.Arg341Ter)	single nucleotide variant	Pathogenic	rs72551349	GRCh37	Chromosome 2, 234676519: 234676519
2	UGT1A1	NM_000463.2(UGT1A1): c.1021C> T (p.Arg341Ter)	single nucleotide variant	Pathogenic	rs72551349	GRCh38	Chromosome 2, 233767873: 233767873
3	UGT1A1	UGT1A1*6	single nucleotide variant	drug response	rs4148323	GRCh37	Chromosome 2, 234669144: 234669144
4	UGT1A1	UGT1A1*6	single nucleotide variant	drug response	rs4148323	GRCh38	Chromosome 2, 233760498: 233760498
5	UGT1A1	NM_000463.2(UGT1A1): c.1198A> G (p.Asn400Asp)	single nucleotide variant	Pathogenic	rs28934877	GRCh37	Chromosome 2, 234676979: 234676979
6	UGT1A1	NM_000463.2(UGT1A1): c.1198A> G (p.Asn400Asp)	single nucleotide variant	Pathogenic	rs28934877	GRCh38	Chromosome 2, 233768333: 233768333
7	UGT1A1	NM_000463.2(UGT1A1): c.674T> G (p.Val225Gly)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs35003977	GRCh37	Chromosome 2, 234669607: 234669607
8	UGT1A1	NM_000463.2(UGT1A1): c.674T> G (p.Val225Gly)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs35003977	GRCh38	Chromosome 2, 233760961: 233760961
9	UGT1A1	NM_000463.2(UGT1A1): c.996+15T> C	single nucleotide variant	Conflicting interpretations of pathogenicity	rs4148327	GRCh37	Chromosome 2, 234675826: 234675826
10	UGT1A1	NM_000463.2(UGT1A1): c.996+15T> C	single nucleotide variant	Conflicting interpretations of pathogenicity	rs4148327	GRCh38	Chromosome 2, 233767180: 233767180
11	UGT1A1	NM_000463.2(UGT1A1): c.1122T> C (p.Gly374=)	single nucleotide variant	Uncertain significance	rs139698110	GRCh37	Chromosome 2, 234676903: 234676903
12	UGT1A1	NM_000463.2(UGT1A1): c.1122T> C (p.Gly374=)	single nucleotide variant	Uncertain significance	rs139698110	GRCh38	Chromosome 2, 233768257: 233768257
13	UGT1A1	NM_000463.2(UGT1A1): c.*211T> C	single nucleotide variant	Benign	rs10929303	GRCh37	Chromosome 2, 234681416: 234681416
14	UGT1A1	NM_000463.2(UGT1A1): c.*211T> C	single nucleotide variant	Benign	rs10929303	GRCh38	Chromosome 2, 233772770: 233772770
15	UGT1A1	NM_000463.2(UGT1A1): c.*585G> T	single nucleotide variant	Uncertain significance	rs886055800	GRCh37	Chromosome 2, 234681790: 234681790
16	UGT1A1	NM_000463.2(UGT1A1): c.*585G> T	single nucleotide variant	Uncertain significance	rs886055800	GRCh38	Chromosome 2, 233773144: 233773144
17	UGT1A1	NM_000463.2(UGT1A1): c.294T> C (p.Asn98=)	single nucleotide variant	Uncertain significance	rs138183896	GRCh37	Chromosome 2, 234669227: 234669227
18	UGT1A1	NM_000463.2(UGT1A1): c.294T> C (p.Asn98=)	single nucleotide variant	Uncertain significance	rs138183896	GRCh38	Chromosome 2, 233760581: 233760581
19	UGT1A1	NM_000463.2(UGT1A1): c.300T> C (p.Phe100=)	single nucleotide variant	Uncertain significance	rs374655757	GRCh37	Chromosome 2, 234669233: 234669233
20	UGT1A1	NM_000463.2(UGT1A1): c.300T> C (p.Phe100=)	single nucleotide variant	Uncertain significance	rs374655757	GRCh38	Chromosome 2, 233760587: 233760587
21	UGT1A1	NM_000463.2(UGT1A1): c.477C> T (p.Ile159=)	single nucleotide variant	Uncertain significance	rs199766420	GRCh37	Chromosome 2, 234669410: 234669410
22	UGT1A1	NM_000463.2(UGT1A1): c.477C> T (p.Ile159=)	single nucleotide variant	Uncertain significance	rs199766420	GRCh38	Chromosome 2, 233760764: 233760764
23	UGT1A1	NM_000463.2(UGT1A1): c.1322T> C (p.Met441Thr)	single nucleotide variant	Uncertain significance	rs202172337	GRCh37	Chromosome 2, 234680925: 234680925
24	UGT1A1	NM_000463.2(UGT1A1): c.1322T> C (p.Met441Thr)	single nucleotide variant	Uncertain significance	rs202172337	GRCh38	Chromosome 2, 233772279: 233772279
25	UGT1A1	NM_000463.2(UGT1A1): c.*339G> C	single nucleotide variant	Benign	rs1042640	GRCh37	Chromosome 2, 234681544: 234681544
26	UGT1A1	NM_000463.2(UGT1A1): c.*339G> C	single nucleotide variant	Benign	rs1042640	GRCh38	Chromosome 2, 233772898: 233772898
27	UGT1A1	NM_000463.2(UGT1A1): c.*201G> A	single nucleotide variant	Uncertain significance	rs541532523	GRCh37	Chromosome 2, 234681406: 234681406
28	UGT1A1	NM_000463.2(UGT1A1): c.*201G> A	single nucleotide variant	Uncertain significance	rs541532523	GRCh38	Chromosome 2, 233772760: 233772760
29	UGT1A1	NM_000463.2(UGT1A1): c.*440G> C	single nucleotide variant	Benign	rs8330	GRCh37	Chromosome 2, 234681645: 234681645
30	UGT1A1	NM_000463.2(UGT1A1): c.*440G> C	single nucleotide variant	Benign	rs8330	GRCh38	Chromosome 2, 233772999: 233772999

Sources

Expression for Gilbert Syndrome

Search GEO for disease gene expression data for Gilbert Syndrome.

Sources

Pathways for Gilbert Syndrome

Pathways related to Gilbert Syndrome according to KEGG:

³⁷

#	Name	Kegg Source Accession
1	Porphyrin and chlorophyll metabolism	hsa00860

Pathways related to Gilbert Syndrome according to GeneCards Suite gene sharing:

(show all 22)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁶ Show member pathways Metabolic pathways ³⁷ Metabolism of lipids and lipoproteins ⁶⁶	13.89	G6PD SLCO1B1 UGT1A1 UGT1A10 UGT1A3 UGT1A4
2	Cytochrome P450 - arranged by substrate type ⁶⁶ Show member pathways Amine Oxidase reactions ⁶⁶ Aryl hydrocarbon receptor signalling ⁶⁶ Benzo(a)pyrene metabolism ¹ Biological oxidations ⁶⁶ bupropion degradation ¹ Clobazam Pathway, Pharmacokinetics ⁶¹ CYP2E1 reactions ⁶⁶ Cytosolic sulfonation of small molecules ⁶⁶ Diclofenac Metabolic Pathway ¹ Eicosanoids ⁶⁶ Endogenous sterols ⁶⁶ Estradiol metabolism ²² Ethanol oxidation ⁶⁶ Fatty Acid Omega Oxidation ¹ Fatty acids ⁶⁶ Metapathway biotransformation ¹ Methylation ⁶⁶ Miscellaneous substrates ⁶⁶ Oxidation by Cytochrome P450 ¹ Phase 1 - Functionalization of compounds ⁶⁶ Phase II conjugation ⁶⁶ Sterols are 12-hydroxylated by CYP8B1 ⁶⁶ Transport and synthesis of PAPS ⁶⁶ Vitamin D2 (ergocalciferol) metabolism ²² vitamin D3 biosynthesis ¹ Vitamins ⁶⁶ Xenobiotics ⁶⁶	13.13	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
3	Drug metabolism - cytochrome P450 ³⁷ Show member pathways Aflatoxin B1 metabolism ¹ Arylamine metabolism ¹ Benzo[a]pyrene metabolism ²² Benzodiazepine Pathway, Pharmacokinetics ⁶¹ Celecoxib Pathway, Pharmacokinetics ⁶¹ Chemical carcinogenesis ³⁷ Drug metabolism - other enzymes ³⁷ Fluvoxamine Pathway, Pharmacokinetics ⁶¹ Haloperidol Pathway, Pharmacokinetics ⁶¹ Ifosfamide Pathway, Pharmacokinetics ⁶¹ Metabolism of xenobiotics by cytochrome P450 ³⁷ Naproxen Pathway, Pharmacokinetics ⁶¹ Oxycodone Pathway, Pharmacokinetics ⁶¹ Retinol metabolism ³⁷ Retinol metabolism ²² Voriconazole Pathway, Pharmacokinetics ⁶¹	12.8	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
4	Glucose / Energy Metabolism ⁴	12.46	G6PD UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6
5	Porphyrin and chlorophyll metabolism ³⁷ Show member pathways Ascorbate and aldarate metabolism ³⁷ Catabolism of glucuronate to xylulose-5-phosphate ⁶⁶ D-glucuronate degradation ¹ Formation of the active cofactor, UDP-glucuronate ⁶⁶ Glucuronidation ⁶⁶ Glucuronidation ¹ heme biosynthesis ¹ Heme biosynthesis ⁶⁶ Heme Biosynthesis ¹ heme biosynthesis from uroporphyrinogen-III I ¹ heme degradation ¹ Heme degradation ⁶⁶ Metabolism of porphyrins ⁶⁶ Pentose and glucuronate interconversions ³⁷ tetrapyrrole biosynthesis ¹	12.39	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
6	NRF2 pathway ¹	12.18	G6PD UGT1A1 UGT1A3 UGT1A4 UGT1A6 UGT1A7
7	Acetaminophen Pathway (therapeutic doses), Pharmacokinetics ⁶¹ Show member pathways 2-Naphthylamine and 2-Nitronaphtalene metabolism ²² Acetaminophen metabolism ²² Acetaminophen Pathway (toxic doses), Pharmacokinetics ⁶¹	11.81	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A8
8	Statin Pathway - Generalized, Pharmacokinetics ⁶¹ Show member pathways Anti-diabetic Drug Nateglinide Pathway, Pharmacokinetics ⁶¹ Anti-diabetic Drug Repaglinide Pathway, Pharmacokinetics ⁶¹ Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics ⁶¹ Fluvastatin Pathway, Pharmacokinetics ⁶¹ Ibuprofen Pathway, Pharmacokinetics ⁶¹ Pravastatin Pathway, Pharmacokinetics ⁶¹ Rosiglitazone Pathway, Pharmacokinetics ⁶¹ Rosuvastatin Pathway, Pharmacokinetics ⁶¹	11.8	SLCO1B1 UGT1A1 UGT1A3 UGT1A9
9	Aryl Hydrocarbon Receptor Pathway ¹	11.62	UGT1A1 UGT1A3 UGT1A4 UGT1A6 UGT1A7 UGT1A9
10	Phenytoin Pathway, Pharmacokinetics ⁶¹ Show member pathways Atomoxetine Pathway, Pharmacokinetics ⁶¹ Carbamazepine Pathway, Pharmacokinetics ⁶¹ Cyclophosphamide Pathway, Pharmacokinetics ⁶¹ Sorafenib Pharmacokinetics ⁶¹	11.59	UGT1A1 UGT1A4 UGT1A6 UGT1A9
11	Tamoxifen Pathway, Pharmacokinetics ⁶¹ Show member pathways Artemisinin and Derivatives Pathway, Pharmacokinetics ⁶¹ Efavirenz Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Tamoxifen metabolism ¹	11.59	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A7 UGT1A8
12	Imipramine/Desipramine Pathway, Pharmacokinetics ⁶¹ Show member pathways Amitriptyline and Nortriptyline Pathway, Pharmacokinetics ⁶¹ Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 ⁶⁶ Citalopram Pathway, Pharmacokinetics ⁶¹ Clomipramine Pathway, Pharmacokinetics ⁶¹ Clopidogrel Pathway, Pharmacokinetics ⁶¹ Clozapine Pathway, Pharmacokinetics ⁶¹ Colchicine Metabolic Pathway ¹ Lidocaine metabolism ¹ Olanzapine Pathway, Pharmacokinetics ⁶¹ Paroxetine Pathway, Pharmacokinetics ⁶¹ Proton Pump Inhibitor Pathway, Pharmacokinetics ⁶¹ Venlafaxine Pathway, Pharmacokinetics ⁶¹ Verapamil Pathway, Pharmacokinetics ⁶¹	11.5	UGT1A3 UGT1A4
13	Estrogen metabolism ¹ Show member pathways Estrogen Metabolism Pathway ⁶¹	11.41	UGT1A1 UGT1A3 UGT1A4 UGT1A6 UGT1A8 UGT1A9
14	Constitutive Androstane Receptor Pathway ¹	11.4	UGT1A1 UGT1A3 UGT1A4 UGT1A6 UGT1A9
15	Gefitinib Pathway, Pharmacokinetics ⁶¹ Show member pathways Doxepin Pathway, Pharmacokinetics ⁶¹ Fluoxetine Pathway, Pharmacokinetics ⁶¹ Imatinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Nevirapine Pathway, Pharmacokinetics ⁶¹ Pazopanib Pathway, Pharmacokinetics ⁶¹ Warfarin Pathway, Pharmacokinetics ⁶¹	11.39	SLCO1B1 UGT1A1
16	Irinotecan Pathway ¹ Show member pathways Irinotecan Pathway, Pharmacodynamics ⁶¹ Irinotecan Pathway, Pharmacokinetics ⁶¹ Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹	11.35	SLCO1B1 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6
17	Codeine and Morphine Pathway, Pharmacokinetics ⁶¹ Show member pathways Codeine and Morphine Metabolism ¹ Ivacaftor pathway, pharmacokinetics/pharmacodynamics ⁶¹ Macrolide Antibiotic Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Tacrolimus/Cyclosporine Pathway, Pharmacokinetics ⁶¹ Tramadol Pharmacokinetics ⁶¹	11.33	SLCO1B1 UGT1A1 UGT1A8
18	Steroid hormone biosynthesis ³⁷ Show member pathways allopregnanolone biosynthesis ¹	11.04	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
19	Erlotinib Pathway, Pharmacokinetics ⁶¹ Show member pathways Atazanavir Pathway, Pharmacokinetics/Pharmacodynamics ⁶¹ Dasatinib Pathway, Pharmacokinetics ⁶¹	10.97	UGT1A1 UGT1A9
20	Valproic Acid Pathway, Pharmacokinetics ⁶¹	10.96	UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A8 UGT1A9
21	Bupropion Pathway, Pharmacokinetics ⁶¹	10.87	UGT1A3 UGT1A4 UGT1A9
22	Nicotine Pathway, Pharmacokinetics ⁶¹ Show member pathways Nicotine Metabolism ¹	10.79	UGT1A4 UGT1A9

Sources

GO Terms for Gilbert Syndrome

Cellular components related to Gilbert Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of membrane	GO:0016021	9.97	SLCO1B1 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6
2	membrane	GO:0016020	9.96	G6PD SLCO1B1 UGT1A1 UGT1A10 UGT1A3 UGT1A4
3	endoplasmic reticulum	GO:0005783	9.76	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
4	endoplasmic reticulum membrane	GO:0005789	9.56	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
5	intracellular membrane-bounded organelle	GO:0043231	9.28	G6PD UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6

Biological processes related to Gilbert Syndrome according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	metabolic process	GO:0008152	9.97	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
2	xenobiotic glucuronidation	GO:0052697	9.76	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
3	retinoic acid metabolic process	GO:0042573	9.72	UGT1A1 UGT1A3 UGT1A7 UGT1A8 UGT1A9
4	flavone metabolic process	GO:0051552	9.65	UGT1A1 UGT1A10 UGT1A7 UGT1A8 UGT1A9
5	negative regulation of catalytic activity	GO:0043086	9.63	UGT1A1 UGT1A7 UGT1A8
6	flavonoid glucuronidation	GO:0052696	9.56	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
7	drug metabolic process	GO:0017144	9.51	UGT1A1 UGT1A7
8	heme catabolic process	GO:0042167	9.49	UGT1A1 UGT1A4
9	coumarin metabolic process	GO:0009804	9.48	UGT1A7 UGT1A8
10	negative regulation of steroid metabolic process	GO:0045939	9.43	UGT1A1 UGT1A8
11	bilirubin conjugation	GO:0006789	9.4	UGT1A1 UGT1A4
12	cellular glucuronidation	GO:0052695	9.17	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7

Molecular functions related to Gilbert Syndrome according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	transferase activity, transferring glycosyl groups	GO:0016757	9.92	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
2	glucuronosyltransferase activity	GO:0015020	9.86	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
3	transferase activity, transferring hexosyl groups	GO:0016758	9.76	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
4	enzyme inhibitor activity	GO:0004857	9.63	UGT1A1 UGT1A7 UGT1A8
5	UDP-glycosyltransferase activity	GO:0008194	9.56	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
6	protein kinase C binding	GO:0005080	9.49	UGT1A10 UGT1A7
7	steroid binding	GO:0005496	9.48	UGT1A1 UGT1A8
8	retinoic acid binding	GO:0001972	9.23	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
9	transferase activity	GO:0016740	10.03	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7
10	protein homodimerization activity	GO:0042803	10.02	G6PD UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6
11	protein heterodimerization activity	GO:0046982	10.01	UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A6 UGT1A7

Sources

Sources for Gilbert Syndrome

¹ BioSystems

² BitterDB

³ CDC

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¹⁰ dbSNP

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¹⁹ FMA

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²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

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²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

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³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

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⁵¹ NDF-RT

⁵² NIH Clinical Center

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⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

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⁶⁴ QIAGEN

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⁶⁶ Reactome

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⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia