Aliases & Classifications for Gingival Disease

MalaCards integrated aliases for Gingival Disease:

Name: Gingival Disease 12 15
Gingival Diseases 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1483
MeSH 44 D005882
SNOMED-CT 68 18718003
UMLS 73 C0017563

Summaries for Gingival Disease

MalaCards based summary : Gingival Disease, also known as gingival diseases, is related to periodontal disease and gingival overgrowth, and has symptoms including snoring, halitosis and tenderness of gums. An important gene associated with Gingival Disease is ANTXR2 (ANTXR Cell Adhesion Molecule 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Doxycycline and Levonorgestrel have been mentioned in the context of this disorder. Affiliated tissues include testes, tonsil and lung, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Gingival Disease

Diseases related to Gingival Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 periodontal disease 30.7 ELANE IL1A IL1B IL6 MMP1 MMP8
2 gingival overgrowth 30.3 FAM20A IL1A IL6 MMP1 SOS1 TGFB1
3 gingivitis 30.2 ELANE IL1A IL1B IL6 MMP8
4 arthritis 28.9 IL1A IL1B IL6 MMP1 TGFB1
5 rheumatoid arthritis 28.7 IL1A IL1B IL6 MMP1 TGFB1 TIMP1
6 asthma 28.6 ELANE IL1A IL1B IL6 MMP1 TGFB1
7 alpha thalassemia-x-linked intellectual disability syndrome 10.2 SMARCA2 SMARCA4
8 recurrent corneal erosion 10.2 IL1B IL6
9 tendinopathy 10.2 MMP1 MMP8
10 bagassosis 10.2 IL1B IL6
11 paraneoplastic syndromes 10.2 IL1B IL6
12 enamel erosion 10.2 GPI SMARCA2 SMARCA4
13 root caries 10.2 GPI SMARCA2 SMARCA4
14 tooth erosion 10.2 GPI SMARCA2 SMARCA4
15 kashin-beck disease 10.2 IL1B MMP1
16 funisitis 10.1 IL1B IL6 MMP8
17 carotid artery disease 10.1 MMP1 MMP8 TIMP1
18 bacterial meningitis 10.1 IL1B IL6 MMP8
19 autoimmune vasculitis 10.1 ELANE IL1B
20 teeth hard tissue disease 10.1 FAM20A GPI SMARCA2
21 chronic ulcer of skin 10.1 ELANE MMP1 MMP8
22 lymph node disease 10.1 IL1B IL6 MMP1
23 mid-dermal elastolysis 10.1 ELANE TIMP1
24 joint disorders 10.1 IL1B IL6 TIMP1
25 cerebral palsy 10.1 IL1B IL6 MMP8
26 bronchiolitis obliterans 10.1 IL6 MMP8 TIMP1
27 mouth disease 10.1 IL1B IL6 MMP8
28 central nervous system tuberculosis 10.1 ELANE IL1B TIMP1
29 synovitis 10.1 IL1B IL6 MMP1
30 inguinal hernia 10.1 IL6 MMP1 TIMP1
31 uremic pruritus 10.0 IL1B IL6
32 acute respiratory distress syndrome 10.0 ELANE IL1B IL6
33 newborn respiratory distress syndrome 10.0 ELANE IL1B IL6
34 periodontitis, chronic 10.0 IL1B IL6 MMP1 MMP8
35 chronic follicular conjunctivitis 10.0 IL1A IL1B
36 giant hemangioma 10.0 SERPINF2 TGFB1
37 pulmonary fibrosis 10.0 IL1B TGFB1 TIMP1
38 preterm premature rupture of the membranes 10.0 IL1B IL6 MMP1 MMP8
39 bronchial disease 10.0 ELANE IL1B IL6
40 appendicitis 10.0 IL1B IL6 MMP8 TIMP1
41 fibromatosis, gingival, 1 10.0 MMP1 SOS1 TGFB1
42 diabetic foot ulcers 10.0 IL6 TGFB1
43 glossitis 10.0 IL1B IL6
44 laryngitis 10.0 IL1B IL6 TGFB1
45 pulmonary emphysema 10.0 ELANE MMP1 MMP8 TIMP1
46 prostatitis 10.0 IL1B IL6 TGFB1
47 fungal keratitis 10.0 MMP8 TIMP1
48 kawasaki disease 10.0 ELANE IL6 TIMP1
49 carpal tunnel syndrome 10.0 IL1B IL6 TGFB1
50 pneumoconiosis 10.0 IL1B IL6 TGFB1

Graphical network of the top 20 diseases related to Gingival Disease:



Diseases related to Gingival Disease

Symptoms & Phenotypes for Gingival Disease

UMLS symptoms related to Gingival Disease:


snoring, halitosis, tenderness of gums

MGI Mouse Phenotypes related to Gingival Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 ELANE GPI IL1A IL1B IL6 MMP1
2 cardiovascular system MP:0005385 10.07 ANTXR2 FAM20A GPI IL1A IL1B IL6
3 immune system MP:0005387 10.03 ANTXR2 ELANE GPI IL1A IL1B IL6
4 mortality/aging MP:0010768 9.9 ANTXR2 ELANE FAM20A GPI IL1B IL6
5 neoplasm MP:0002006 9.65 ELANE IL1A IL1B IL6 MMP1 MMP8
6 skeleton MP:0005390 9.23 FAM20A IL1B IL6 SMARCA2 SMARCA4 SOS1

Drugs & Therapeutics for Gingival Disease

Drugs for Gingival Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 257)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Levonorgestrel Approved, Investigational Phase 4 17489-40-6, 797-63-7 13109
3
Hexetidine Approved, Investigational Phase 4 141-94-6
4
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 55-56-1 2713 9552079
5
Miconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 22916-47-8 4189
6 sodium fluoride Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 7681-49-4
7
Minocycline Approved, Investigational Phase 4,Phase 3,Not Applicable 10118-90-8 5281021
8
Ethanol Approved Phase 4,Phase 3,Not Applicable 64-17-5 702
9 Lycopene Approved, Investigational Phase 4 502-65-8 446925
10
Thymol Approved Phase 4,Not Applicable 89-83-8 6989
11
Zinc Approved, Investigational Phase 4,Phase 2 7440-66-6
12
Methyl salicylate Approved, Vet_approved Phase 4,Not Applicable 119-36-8 4133
13
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
14
Azithromycin Approved Phase 4,Not Applicable 83905-01-5 55185 447043
15
Metronidazole Approved Phase 4,Phase 3,Not Applicable 443-48-1 4173
16
Cetylpyridinium Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 7773-52-6
17
Triclosan Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 3380-34-5 5564
18
Acetaminophen Approved Phase 4 103-90-2 1983
19
Epinephrine Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 51-43-4 5816
20
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
21
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
22
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
23
Racepinephrine Approved Phase 4,Not Applicable,Early Phase 1 329-65-7 838
24
Coal tar Approved Phase 4,Not Applicable 8007-45-2
25
Eucalyptol Approved, Nutraceutical Phase 4,Not Applicable 470-82-6 2758
26
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 5785 54670067
27
Epicatechin Investigational Phase 4 490-46-0 72276
28 Anesthetics Phase 4,Not Applicable
29 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
30 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Contraceptives, Oral Phase 4
32 Contraceptive Agents Phase 4
33 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
34 Antimalarials Phase 4
35 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
36 Progestins Phase 4
37 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2,Not Applicable
38 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Antifungal Agents Phase 4,Not Applicable
40 Disinfectants Phase 4,Phase 3,Phase 2,Not Applicable
41 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
42 Dermatologic Agents Phase 4,Phase 3,Phase 2,Not Applicable
43 Fluorides Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
44 Listerine Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
45 Cariostatic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
46 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
47 Gelatin Sponge, Absorbable Phase 4
48 Coagulants Phase 4,Phase 3,Not Applicable
49 Hemostatics Phase 4,Phase 3,Not Applicable
50 Acidophilus Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 410)
# Name Status NCT ID Phase Drugs
1 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
2 Norplant and Irregular Bleeding/Spotting Unknown status NCT00064766 Phase 4 doxycycline
3 Methodology Antiseptic Application, Influence on Oral Biofilm. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
4 Pinhole Surgical Technique With And Without Use Of Buttons For Treatment Of Multiple Gingival Recessions: RCT Unknown status NCT02632968 Phase 4
5 Laser De-epithelialization for Epithelial Exclusion in Root Coverage Procedure: a Clinical Study Unknown status NCT02626117 Phase 4
6 Platelet Rich Fibrin in the Treatment of Palatal Wounds Unknown status NCT02438046 Phase 4
7 Efficacy of Different Chlorhexidine Concentrations Unknown status NCT02911766 Phase 4 Chlorhexidine 0.2% Mouthrinse;Chlorhexidine 0.12% mouthrinse;Chlorhexidine 0.06% mouthrinse
8 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). Unknown status NCT01778699 Phase 4
9 Long-term Safety of Minocycline in Patients With Gum Disease Completed NCT00668746 Phase 4 Minocycline HCl microspheres
10 A Clinical Trial to Test the Effect of Experimental Mouth Rinse on Gum Disease Completed NCT02065414 Phase 4
11 A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus Completed NCT02263352 Phase 4 Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
12 Mechanical-chemical Gingival Therapy in Diabetics and/or Obese Completed NCT02123563 Phase 4
13 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
14 Treatment of Periodontitis by Conventional 4 Weekly Sections or Within 24 Hours Completed NCT02215460 Phase 4 FMS chlorhexidine rinse;FMS placebo rinse;FMS azithromycin tablets;FMS placebo tablets;QS azithromycin tablets;QS placebo tablets;QS chlorhexidine rinse;QS placebo rinse
15 Evaluation of the Effects of Different Analgesics on Pericoronitis Pain and Quality of Life Completed NCT03745599 Phase 4 Diclofenac;Flurbiprofen;Benzydamine
16 Effectiveness of Metronidazole Gel and Mobile SMS Reminders on Gingivitis in Orthodontic Patients Completed NCT03508999 Phase 4 Metronidazole gel
17 Estimation of Interleukin-21 Levels in Gingival Crevicular Fluid in Patients With Periodontal Health and Disease Following Non-surgical Periodontal Therapy: A Clinico-biochemical Study Completed NCT02861937 Phase 4
18 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs Completed NCT02515929 Phase 4
19 "The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients. Completed NCT02154594 Phase 4 Acacia catechu;Chlorhexidine gluconate
20 An Efficacy Study of Chlorhexidine Mouthwashes Completed NCT01751178 Phase 4 Chlorhexidine Digluconate Mouthwash with Alcohol;Chlorhexidine Digluconate Mouthwash without Alcohol
21 Effect of Probiotic on the Plaque pH. A Randomized Double Blind Interventional Study Completed NCT01601145 Phase 4
22 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00855933 Phase 4
23 Compare Anti-inflammatory Dentifrices Completed NCT00762528 Phase 4 Triclosan/Copolymer/fluoride toothpaste;Sodium monofluorophosphate toothpaste
24 Clinical Examination of Metal Free Interdental Brushes Completed NCT01593540 Phase 4
25 Evaluation of the Inflammatory and Healing Profile After Root Coverage With Emdogain® Completed NCT03059966 Phase 4
26 Coronally Advanced Flap and PRF With or Without Demineralized Freeze-dried Bone Allograft in Gingival Recession Completed NCT02835430 Phase 4
27 Treatment of Multiple Gingival Recessions Completed NCT02818855 Phase 4 Collagen Matrix
28 Tunnel With and Without Intramucosal Vertical Incisions Completed NCT02486991 Phase 4
29 Semilunar Coronally Positioned Flap With or Without Enamel Matrix Derivative for the Treatment of Gingival Recessions Completed NCT02459704 Phase 4
30 Xenogenous Collagen Matrix Graft With or Without Enamel Matrix Proteins Derivative for Root Coverage Completed NCT02456337 Phase 4
31 Clinical Evaluation of Single-stage Advanced Versus Rotated Flaps in the Treatment of Gingival Recessions Completed NCT02433912 Phase 4 750 mg paracetamol;chlorhexidine gluconate
32 Microsurgical Versus Conventional Semilunar Coronally Advanced Flap Completed NCT02433899 Phase 4 Dexamethasone;Chlorhexidine gluconate;2.0% Mepivacaine + 1:100.000 epinephrine
33 Coronally Advanced Flap With or Without Porcine Collagen Matrix for Root Coverage Completed NCT02242500 Phase 4
34 Gingival Recession Coverage With and Without Emdogain Completed NCT02230787 Phase 4
35 Connective Tissue Graft Versus Mucograft Collagen Matrix for Coverage of Multiple Gingival Recession Defects Completed NCT01440426 Phase 4
36 Coronally Advanced Flap in Combination With Acellular Dermal Matrix and Enamel Matrix Derivatives for Root Coverage Completed NCT00720707 Phase 4
37 Effect of Mouthrinsing on Inflammation of the Gums. Completed NCT01317446 Phase 4 amine fluoride/stannous fluoride
38 Evaluate Inflammation Caused by Gingivitis in Adults Completed NCT00941668 Phase 4 Triclosan/Copolymer/fluoride toothpaste;sodium monofluorophosphate toothpaste
39 Essential Oil+ELA, Plaque and Gingivitis Completed NCT02884817 Phase 4 Experimental: essential oils and ELA
40 Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash) Completed NCT02366689 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride only toothpaste;Cetylpyridinium chloride mouthwash;Fluoride only mouthwash
41 The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Completed NCT02360995 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride toothpaste;Fluoride Mouthwash;cetylpyridinium chloride Mouthwash
42 Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste Completed NCT02080273 Phase 4 Colgate Cavitity Protection toothpaste;Colgate Total toothpaste;Parodontax toothpaste
43 Effects of Two Sugar Substituted Chewing Gums on Caries and Gingivitis Variables Completed NCT01578603 Phase 4
44 Treatment of Periodontitis in Obese Individuals Recruiting NCT03103204 Phase 4
45 A Clinical Trial Testing Root Coverage With Acellular Dermal Matrix in Thin and Thick Gingival Biotypes Recruiting NCT03057730 Phase 4
46 Randomized Trial to Evaluate the Efficacy of Two Different Toothbrushes on Plaque Control Active, not recruiting NCT03099551 Phase 4
47 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis Active, not recruiting NCT03219840 Phase 4 CPC;Placebo
48 Mouthwashes During Orthodontic Treatment Enrolling by invitation NCT03179735 Phase 4 Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
49 Evaluation of The Effect of Live Probiotic Cultures Present in Fermented Dairy Product (Yogurt) Versus The Effect of Freeze-Dried Probiotic Sachets on Gingival Bleeding, Dental Plaque pH and Oral Health of Adolescents Not yet recruiting NCT03640065 Phase 4 freeze-dried probiotic sachets
50 Efficacy of a Mouthwash Containing Propolis Unknown status NCT01750801 Phase 3 Propolis;chlorhexidine

Search NIH Clinical Center for Gingival Disease

Cochrane evidence based reviews: gingival diseases

Genetic Tests for Gingival Disease

Anatomical Context for Gingival Disease

MalaCards organs/tissues related to Gingival Disease:

41
Testes, Tonsil, Lung, Skin, Liver, Bone, Lymph Node

Publications for Gingival Disease

Articles related to Gingival Disease:

(show all 47)
# Title Authors Year
1
Non-plaque-induced gingival diseases. ( 29926497 )
2018
2
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. ( 29926499 )
2018
3
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. ( 29926944 )
2018
4
Non-plaque-induced gingival diseases. ( 29926945 )
2018
5
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. ( 30050201 )
2018
6
Factors associated with the risk of gingival disease in patients with rheumatoid arthritis. ( 29023518 )
2017
7
Assessment of Vitamin B12 and Its Correlation with Dental Caries and Gingival Diseases in 10- to 14-year-old Children: A Cross-sectional Study. ( 28890613 )
2017
8
Angiosarcoma: A Case Report of Gingival Disease with Both Palatine Tonsils Localization. ( 27746875 )
2016
9
The antiplaque effect of herbal mouthwash in comparison to chlorhexidine in human gingival disease: a randomized placebo controlled clinical trial. ( 24698829 )
2014
10
Gingival diseases in childhood - a review. ( 25478471 )
2014
11
Arsenicals for dental and gingival diseases in medieval Persia. ( 23332432 )
2013
12
Gingival disease and secretory immunoglobulin a in non-stimulated saliva in children. ( 21462892 )
2010
13
Is bronchial asthma a risk factor for gingival diseases? A control study. ( 19280828 )
2009
14
Oral medicine case book 10. Gingival diseases. ( 19054910 )
2008
15
Prevalence of gingival diseases, malocclusion and fluorosis in school-going children of rural areas in Udaipur district. ( 17660647 )
2007
16
Sulcular sulfide monitoring: an indicator of early dental plaque-induced gingival disease. ( 16451765 )
2006
17
Differential gene expression of human beta-defensins (hBD-1, -2, -3) in inflammatory gingival diseases. ( 15836521 )
2005
18
A clinical trial of the effect of a mouth-rinse prepared with Lippia sidoides Cham essential oil in dogs with mild gingival disease. ( 12719020 )
2003
19
Gingival disease associated with a decorative crown. ( 11874059 )
2002
20
Factitial (self-induced) gingival disease: four case reports. ( 11820044 )
2001
21
Dental plaque-induced gingival diseases. ( 10863371 )
1999
22
An evaluation of a dentifrice containing salivary peroxidase elements for the control of gingival disease in patients with irradiated head and neck cancer. ( 8887803 )
1996
23
Serum responses of cats with periodontal/gingival disease to members of the genus Porphyromonas. ( 7548583 )
1995
24
Posttransplantation lymphoproliferative gingival disease. ( 7579379 )
1995
25
Serum antibody levels to oral microorganisms in children and young adults with relation to the severity of gingival disease. ( 1815198 )
1991
26
Socio-economic risk factors for gingival disease in children. ( 2637359 )
1989
27
A clinical and microbiologic examination of gingival disease in parapubescent females. ( 3489831 )
1986
28
Gingival disease in children--an emerging problem. ( 6954255 )
1982
29
The relationships between irregular teeth, plaque, calculus and gingival disease. A study of 300 subjects. ( 6928101 )
1980
30
Some characteristics of collagenase activity in gingival crevicular fluid and its relationship to gingival diseases in humans. ( 187631 )
1976
31
The effect of 0.5% chlorhexidine gel on gingival disease--report of pilot study. ( 1071093 )
1975
32
Lymphocyte-fibroblast interaction in the pathogenesis of inflammatory gingival disease. ( 5087049 )
1972
33
Studies in dentifrices. 3. The prevalence of gingival disease in children 12-14 years of age in relation to toothbrushing by means of different dentifrices. ( 5273241 )
1970
34
Dental calculus and bacterial plaque and their relationship to gingival disease in 400 individuals. ( 5272470 )
1970
35
Gingival disease prevalence in mentally handicapped adults. The effects of an oral hygiene programme. ( 5260558 )
1969
36
The differential diagnosis of gingival disease with special reference to Vincent's infection. ( 5231147 )
1967
37
The differential diagnosis of gingival disease with special reference to Vincent's infection. ( 5945751 )
1966
38
Effect of geographic location and race on gingival disease in children. ( 13788544 )
1960
39
The effect of clorpactin on gingival disease; preliminary report. ( 13322423 )
1956
40
Gingival disease in the Virgin Islands. ( 15402122 )
1950
41
Gingival disease in relation to systemic disorders. ( 20291904 )
1947
42
Experimental investigation of parodontal disease; further clinical studies of sugar-cane gnawing in treatment of gingival disease. ( 18895814 )
1947
43
A basic approach to the problem of gingival disease. ( 20294315 )
1947
44
Gingival disease in postwar Italy (1945) gingivosis in hospitalized children in Naples. ( 20266565 )
1947
45
Gingival disease in postwar Italy (1945) prevalence of gingivitis in various age groups. ( 20260900 )
1947
46
A basic approach to the problems of gingival disease. ( 20292533 )
1947
47
Experimental investigations of parodontal disease; gnawing of sugar cane in the treatment of non-ulcerative gingival disease in man. ( 20294239 )
1947

Variations for Gingival Disease

Expression for Gingival Disease

Search GEO for disease gene expression data for Gingival Disease.

Pathways for Gingival Disease

Pathways related to Gingival Disease according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 ELANE GPI IL1A IL1B IL6 MMP1
2
Show member pathways
13.62 IL1A IL1B IL6 SMARCA2 SMARCA4 SOS1
3
Show member pathways
13.22 IL1A IL1B IL6 MMP1 SMARCA4 SOS1
4
Show member pathways
12.82 IL1A IL1B IL6 SOS1 TGFB1
5
Show member pathways
12.68 ELANE MMP1 MMP8 TGFB1 TIMP1
6
Show member pathways
12.64 IL1A IL1B IL6 TGFB1 TIMP1
7
Show member pathways
12.53 IL1A IL1B IL6 TGFB1
8
Show member pathways
12.52 IL1B IL6 SOS1 TIMP1
9
Show member pathways
12.3 IL1A IL1B IL6 SOS1 TGFB1
10
Show member pathways
12.25 IL1A IL1B IL6 SOS1
11
Show member pathways
12.17 IL1A IL1B MMP1 MMP8 SOS1
12 12.17 IL1A IL1B IL6 TGFB1
13
Show member pathways
12.17 IL1A IL1B IL6 TGFB1 TIMP1
14
Show member pathways
12.15 IL1A IL1B IL6 SOS1
15 12.1 IL6 MMP1 SOS1 TGFB1
16
Show member pathways
11.99 IL1B IL6 TGFB1
17 11.98 IL1A IL1B TGFB1
18 11.92 IL1A IL1B IL6 TGFB1
19
Show member pathways
11.92 IL1A IL1B IL6 SOS1 TGFB1 TIMP1
20 11.85 IL1A IL1B IL6 TGFB1
21 11.84 IL1A IL1B IL6
22 11.83 IL1B IL6 TGFB1
23
Show member pathways
11.78 IL6 SOS1 TIMP1
24 11.77 IL1A IL1B IL6
25 11.77 IL1A IL1B IL6 TGFB1
26
Show member pathways
11.75 ELANE MMP1 MMP8 TIMP1
27 11.74 IL6 MMP1 SMARCA4
28 11.7 IL1A IL1B IL6
29 11.69 IL1B IL6 TGFB1
30 11.68 IL6 SOS1 TGFB1 TIMP1
31 11.66 IL1B IL6 TGFB1
32 11.5 IL1B IL6 TGFB1 TIMP1
33
Show member pathways
11.47 IL1A IL1B IL6 MMP1
34 11.46 IL1B IL6 TGFB1
35 11.45 IL1A IL1B IL6
36 11.41 IL1A IL1B IL6
37 11.33 IL6 MMP1 SOS1 TGFB1
38 11.31 IL1A IL1B IL6 MMP1 TGFB1
39 11.28 IL1A IL1B IL6
40 11.27 IL1A IL1B IL6
41 11.25 IL1A IL1B IL6 TIMP1
42 11.16 IL1A IL1B IL6 MMP1 TGFB1 TIMP1
43 10.97 MMP1 TIMP1
44 10.96 IL1A IL1B IL6 TGFB1 TIMP1
45 10.92 MMP1 TGFB1
46 10.92 IL1A IL1B IL6 TGFB1
47 10.48 IL1A IL1B

GO Terms for Gingival Disease

Cellular components related to Gingival Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ELANE FAM20A GPI IL1A IL1B IL6
2 extracellular matrix GO:0031012 9.67 MMP1 MMP8 TGFB1 TIMP1
3 collagen-containing extracellular matrix GO:0062023 9.62 ELANE MMP8 SERPINF2 TGFB1
4 secretory granule GO:0030141 9.58 ELANE IL1B TGFB1
5 SWI/SNF complex GO:0016514 9.46 SMARCA2 SMARCA4
6 nBAF complex GO:0071565 9.43 SMARCA2 SMARCA4
7 extracellular region GO:0005576 9.4 ANTXR2 ELANE FAM20A GPI IL1A IL1B
8 platelet alpha granule lumen GO:0031093 9.33 SERPINF2 TGFB1 TIMP1
9 npBAF complex GO:0071564 9.26 SMARCA2 SMARCA4

Biological processes related to Gingival Disease according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.95 IL1A IL1B IL6 SMARCA2 TGFB1
2 positive regulation of gene expression GO:0010628 9.92 IL1A IL1B IL6 MMP8 TGFB1
3 regulation of signaling receptor activity GO:0010469 9.85 GPI IL1A IL1B IL6 TGFB1 TIMP1
4 platelet degranulation GO:0002576 9.82 SERPINF2 TGFB1 TIMP1
5 negative regulation of cell growth GO:0030308 9.81 SMARCA2 SMARCA4 TGFB1
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.8 IL1B IL6 SMARCA4
7 response to estradiol GO:0032355 9.8 GPI IL1B TGFB1
8 wound healing GO:0042060 9.79 IL1B TGFB1 TIMP1
9 response to organic substance GO:0010033 9.77 SERPINF2 TGFB1 TIMP1
10 positive regulation of JNK cascade GO:0046330 9.75 IL1B MMP8 SERPINF2
11 positive regulation of interleukin-6 production GO:0032755 9.73 IL1B IL6 MMP8
12 leukocyte migration GO:0050900 9.72 ELANE IL1B MMP1 SOS1 TGFB1
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.71 ELANE IL6 SERPINF2
14 positive regulation of cell division GO:0051781 9.67 IL1A IL1B TGFB1
15 response to vitamin D GO:0033280 9.65 IL1B TGFB1
16 positive regulation of histone acetylation GO:0035066 9.65 IL1B TGFB1
17 positive regulation of glial cell proliferation GO:0060252 9.63 IL1B IL6
18 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.61 IL1A IL1B
19 positive regulation of vascular endothelial growth factor production GO:0010575 9.61 IL1A IL1B TGFB1
20 cell activation GO:0001775 9.59 TGFB1 TIMP1
21 positive regulation of immunoglobulin secretion GO:0051024 9.58 GPI IL6
22 response to immobilization stress GO:0035902 9.58 GPI IL1B TGFB1
23 ectopic germ cell programmed cell death GO:0035234 9.57 IL1A IL1B
24 extracellular matrix disassembly GO:0022617 9.56 ELANE MMP1 MMP8 TIMP1
25 fever generation GO:0001660 9.48 IL1A IL1B
26 negative regulation of chemokine biosynthetic process GO:0045079 9.46 ELANE IL6
27 positive regulation of neuroinflammatory response GO:0150078 9.33 IL1B IL6 MMP8
28 cytokine-mediated signaling pathway GO:0019221 9.17 IL1A IL1B IL6 MMP1 SOS1 TGFB1
29 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.13 IL1A TGFB1 TIMP1
30 positive regulation of transcription by RNA polymerase II GO:0045944 10.05 IL1A IL1B IL6 SERPINF2 SMARCA2 SMARCA4
31 positive regulation of transcription, DNA-templated GO:0045893 10.02 IL1B IL6 SMARCA2 SMARCA4 TGFB1

Molecular functions related to Gingival Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.5 ELANE SERPINF2 TIMP1
2 endopeptidase activity GO:0004175 9.43 ELANE MMP1 MMP8
3 interleukin-1 receptor binding GO:0005149 9.37 IL1A IL1B
4 growth factor activity GO:0008083 9.26 GPI IL6 TGFB1 TIMP1
5 hydrolase activity, acting on acid anhydrides GO:0016817 9.16 SMARCA2 SMARCA4
6 cytokine activity GO:0005125 9.1 GPI IL1A IL1B IL6 TGFB1 TIMP1

Sources for Gingival Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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