Aliases & Classifications for Gingival Disease

MalaCards integrated aliases for Gingival Disease:

Name: Gingival Disease 12 15 17
Gingival Diseases 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1483
MeSH 43 D005882
SNOMED-CT 67 18718003
UMLS 71 C0017563

Summaries for Gingival Disease

MalaCards based summary : Gingival Disease, also known as gingival diseases, is related to gingival overgrowth and gingivitis, and has symptoms including halitosis, snoring and tenderness of gums. An important gene associated with Gingival Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs sodium fluoride and Triclosan have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and liver, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Gingival Disease

Diseases related to Gingival Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 584)
# Related Disease Score Top Affiliating Genes
1 gingival overgrowth 31.5 TNF TIMP1 SOS1 MMP8 MMP1 IL6
2 gingivitis 31.5 TNF MMP8 MMP1 IL6 IL1B ELANE
3 candidiasis 30.3 TNF IL6 IL1B CXCL8
4 gingival recession 30.1 SERPINF2 MMP8 KCNK6 IL1B CRP AMBN
5 stomatitis 30.1 TNF IL6 IL1B CXCL8 CD4
6 periodontitis 29.6 TNFSF11 TNF TIMP1 MMP8 MMP1 IL6
7 rheumatoid arthritis 28.5 TNFSF11 TNF TIMP1 SERPINA3 MMP8 MMP1
8 external pathological resorption 10.7 TNF IL6
9 scorpion envenomation 10.7 TNF IL6
10 systemic onset juvenile idiopathic arthritis 10.7 TNF IL1B
11 angelucci's syndrome 10.7 IL1B CXCL8
12 dermatitis, atopic, 8 10.7 IL1B CXCL8
13 osteosclerotic myeloma 10.6 IL6 IL1B
14 staphylococcal toxic shock syndrome 10.6 TNF IL1B
15 acute transverse myelitis 10.6 IL6 CXCL8
16 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 TNF IL6
17 drug reaction with eosinophilia and systemic symptoms 10.6 TNF CRP
18 conjunctivitis 10.6 TNF IL6 CXCL8
19 gastric squamous cell carcinoma 10.6 SERPINA3 CCR6
20 cold agglutinin disease 10.6 IL6 CRP
21 trichuriasis 10.6 TNF SERPINA3 CCR6
22 esophagus melanoma 10.6 IL1B CXCL8
23 vulvar vestibulitis syndrome 10.6 TNF IL1B
24 stachybotrys chartarum 10.6 TNF IL6 IL1B
25 recurrent corneal erosion 10.6 IL6 IL1B CXCL8
26 idiopathic anterior uveitis 10.6 TNF IL6 CXCL8
27 platelet aggregation, spontaneous 10.6 SERPINF2 SERPINA3
28 palladium allergic contact dermatitis 10.6 TNF IL1B
29 eales disease 10.6 TNF IL6 IL1B
30 autoimmune inner ear disease 10.6 TNF TIMP1
31 kashin-beck disease 10.6 TNF IL1B
32 streptococcal toxic-shock syndrome 10.6 TNF IL6 CXCL8
33 peptic esophagitis 10.6 IL6 IL1B CXCL8
34 tendinopathy 10.6 MMP8 MMP1
35 autoimmune disease of skin and connective tissue 10.6 SERPINA3 CD4 CCR6
36 intestinal schistosomiasis 10.6 SIGLEC5 CD4 CCR6
37 tularemia 10.6 TNF IL6 CD4
38 idiopathic neutropenia 10.6 TNF IL6 IL1B
39 hyper ige recurrent infection syndrome 1 10.6 IL6 CD4 CCR6
40 acute monoblastic leukemia 10.6 SOS1 IL6 CXCL8
41 dentine erosion 10.6 CCR6 AMBN
42 intermediate uveitis 10.6 TNF IL6 CCR6
43 glossitis 10.6 TNF IL6 IL1B
44 prosthetic joint infection 10.6 IL6 IL1B CRP
45 transverse myelitis 10.6 TNF IL6 CXCL8
46 uremic pruritus 10.6 IL6 IL1B CRP
47 blastomycosis 10.6 TNF CD4 CCR6
48 burning mouth syndrome 10.6 TNF IL6 IL1B
49 cardiogenic shock 10.6 IL6 CRP
50 blepharoconjunctivitis 10.6 MMP8 CXCL8 CD4

Graphical network of the top 20 diseases related to Gingival Disease:



Diseases related to Gingival Disease

Symptoms & Phenotypes for Gingival Disease

UMLS symptoms related to Gingival Disease:


halitosis, snoring, tenderness of gums

MGI Mouse Phenotypes related to Gingival Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 CCR6 CD4 CRP ELANE IL1B IL6
2 immune system MP:0005387 9.73 CCR6 CD4 CRP ELANE IL1B IL6
3 neoplasm MP:0002006 9.32 AMBN ELANE IL1B IL6 MMP1 MMP8

Drugs & Therapeutics for Gingival Disease

Drugs for Gingival Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 sodium fluoride Approved Phase 3 7681-49-4
2
Triclosan Approved, Investigational Phase 3 3380-34-5 5564
3 Anti-Infective Agents Phase 3
4 Hypolipidemic Agents Phase 3
5 Listerine Phase 3
6 Lipid Regulating Agents Phase 3
7 Antimetabolites Phase 3
8 Anti-Infective Agents, Local Phase 3
9 Anti-Anxiety Agents Phase 3
10 Honokiol Phase 3 35354-74-6
11 Central Nervous System Depressants Phase 3
12 Anti-Arrhythmia Agents Phase 3
13 Tranquilizing Agents Phase 3
14 Gastrointestinal Agents Phase 3
15 Anti-Bacterial Agents Phase 3
16 Magnolol Phase 3 528-43-8
17 Psychotropic Drugs Phase 3
18 Anti-Allergic Agents Phase 3
19 Fluorophosphate Phase 3
20 Chlorhexidine gluconate Phase 3
21 Disinfectants Phase 3
22
Ustekinumab Approved, Investigational Phase 1, Phase 2 815610-63-0
23 Dermatologic Agents Phase 1, Phase 2
24 Antibodies, Monoclonal Phase 1, Phase 2
25 Interleukin-12 Phase 1, Phase 2
26 Antibodies Phase 1, Phase 2
27 Immunoglobulins Phase 1, Phase 2
28 Immunologic Factors Phase 1, Phase 2
29 Gotu Kola Phase 1
30
Ethanol Approved 64-17-5 702
31
Eugenol Approved 97-53-0 3314
32 Anti-Inflammatory Agents
33 Caryophyllene
34 Holy Basil
35 Sweet Basil
36 Fluorides
37 Protective Agents
38 Cariostatic Agents
39 Anesthetics

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Collection of Gingival Crevicular Fluid From Periodontitis Patients Completed NCT00763048 Phase 3 Fluoride;Fluoride, triclosan
2 Clinical Study to Examine Brushing on Dental Implants Completed NCT00762619 Phase 3 Fluoride;Triclosan, fluoride
3 Compare the Clinical Efficacy of Prototype Toothpastes. Completed NCT00761930 Phase 3 Fluoride;Triclosan and fluoride;Herbal Ingredient and fluoride
4 Clinical Study to Evaluate Dental Plaque Completed NCT00758290 Phase 3 Triclosan/Fluoride;Fluoride/triclosan
5 Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing. Completed NCT00966953 Phase 3 Fluoride;Triclosan/Fluoride toothpaste;Fluoride;Fluoride
6 Evaluate Clinical Research From Commerical Oral Care Products Completed NCT00759187 Phase 3 Fluoride;Triclosan/Fluoride;Chlorhexidine Gluconate
7 Phase II Pilot Efficacy Study to Treat Gingivitis Completed NCT00391547 Phase 2 Frio Oral Rinse
8 Use of Ustekinumab (Anti-IL-12/23p40 Monoclonal Antibody) in Patients With Leukocyte Adhesion Deficiency Type 1 (LAD1) Who Have Inflammatory Pathology Recruiting NCT03366142 Phase 1, Phase 2 Ustekinumab
9 Clinical Evaluation of the Centella Asiatica (Gotukola) Mouthwash as an Adjunct to Mechanical Plaque Control: A RCT Completed NCT02827305 Phase 1 Gotukola
10 Effect of Non-surgical Periodontal Therapy on Systemic Inflammation in Thalassemia Major Patients With Chronic Periodontitis: A Randomised Controlled Clinical Trial Completed NCT03311243 Chemical plaque control
11 A Study to Measure the Effect of Two Fluoride Toothpastes on Gingival Health Over a Six Month Period Completed NCT03027908
12 A Randomized, Controlled Clinical Trial to Evaluate a Xenogeneic Collagen Matrix as an Alternative to Free Gingival Grafting for Oral Soft Tissue Augmentation Completed NCT01952301
13 Impact of Periodontal Therapy in Flow-mediated Dilation and Serum Levels of Cardiovascular Risk Biomarkers in Coronary Artery Disease Patients: 12 Months Randomized Controlled Trial Completed NCT01609725
14 Coronally Advanced Flap With Two Different Techniques for the Treatment of Multiple Gingival Recessions: A Split-mouth RCT Completed NCT02229669
15 The Effect of Periodontal Treatment on Depression, Body Image, Self-Esteem and Anxiety in Depressed Patients: A Randomized Controlled Clinical Trial Completed NCT03190512
16 Prospective Clinical Evaluation of Periodontal Response to Different Prosthetic Margin Design Completed NCT02276586
17 A 6-month Randomized, Controlled, Open-label, 2-arm Parallel Group, Multicenter Study to Evaluate the Effect of Switching From Cigarette Smoking to the Use of IQOS in Smokers With Generalized Chronic Periodontitis on the Response to Mechanical Periodontal Treatment and Oral Health Status. Completed NCT03364751
18 A Clinical Study to Investigate the Efficacy of New Alcohol Free Mouthrinses Completed NCT01811615
19 Comparation Between Two Surgical Techniques With Acellular Dermal Matrix in Treatment of Gingival Recessions Completed NCT02774967
20 Efficacy of Ocimum Sanctum as a Pre-procedural Mouth Rinse in Reducing Aerosol Contamination Produced by Ultrasonic Scaler: a Clinical and Microbiological Study. Completed NCT03839719
21 Retrospective Clinico-pathological Examinations on Different Histological/ Immunohistological and Molecularpathological Types of Epulides and Central Giant Cell Lesions of the Jaws Recruiting NCT03829059
22 LifE Style, Nutrition and Oral Health in Care Givers) Recruiting NCT04003493
23 Evaluation of Matrix Metalloproteinase 8 Salivary Test for Periodontal Diagnosis in Infertile Women Recruiting NCT03542630
24 Impact of Compliance With Fluoride Use on Caries Incidence After Cancer Therapy Recruiting NCT03267914
25 Evaluation of Gingival Health Parameters in Hybrid CAD / CAM Crowns Produced After Different Retraction Processes Active, not recruiting NCT03816930
26 Oral Health Status and Diet History Analysis Among Orphan House Children From 10-14 Years in Cairo Governorate : A Cross Sectional Study Not yet recruiting NCT04167826
27 Impact of an Educational Program on Oral Health Related Quality of Life in a Group of 11 to 14 Years Old Egyptian Children: Before and After Study. Not yet recruiting NCT03723174
28 Randomized Prospective Study for the Comparison of Sample Biopsy Using Scalpel or Er:YAG Laser Not yet recruiting NCT03638973

Search NIH Clinical Center for Gingival Disease

Cochrane evidence based reviews: gingival diseases

Genetic Tests for Gingival Disease

Anatomical Context for Gingival Disease

MalaCards organs/tissues related to Gingival Disease:

40
Bone, Heart, Liver, Lung, Skin, Eye, Tonsil

Publications for Gingival Disease

Articles related to Gingival Disease:

(show top 50) (show all 207)
# Title Authors PMID Year
1
Oral Manifestations in HIV-Positive Children: A Systematic Review. 61
32023908 2020
2
A systematic review of oral health in people with multiple sclerosis. 61
31815299 2019
3
Patients' knowledge and opinions regarding osteoporosis, osteoporosis treatment, and oral health care. 61
31561759 2019
4
The Effect of Oral Health Knowledge, Attitude, and Practice on Periodontal Status among Dental Students. 61
31627215 2019
5
Esthetic Management of Peripheral Giant Cell Granuloma Affecting a Dental Implant in the Esthetic Zone. 61
31498570 2019
6
Tobacco-use patterns and self-reported oral health outcomes: A cross-sectional assessment of the Population Assessment of Tobacco and Health study, 2013-2014. 61
30922519 2019
7
Protective role of flavonoid baicalin from Scutellaria baicalensis in periodontal disease pathogenesis: A literature review. 61
29857875 2018
8
Dental plaque-induced gingival conditions. 61
29926958 2018
9
Dental plaque-induced gingival conditions. 61
29926503 2018
10
Oral diseases associated with condition-specific oral health-related quality of life and school performance of Thai primary school children: A hierarchical approach. 61
29315720 2018
11
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. 61
29926944 2018
12
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. 61
29926499 2018
13
Non-plaque-induced gingival diseases. 61
29926945 2018
14
Non-plaque-induced gingival diseases. 61
29926497 2018
15
Lead exposure may affect gingival health in children. 61
29728081 2018
16
Nonsyndromic Gingival Fibromatosis: A Rare Case Report. 61
30131651 2018
17
Global oral health status of athletes with intellectual disabilities. 61
29119318 2018
18
Clinical Effects of Stabilized Stannous Fluoride Dentifrice in Reducing Plaque Microbial Virulence II: Metabonomic Changes. 61
29758151 2018
19
Dental Caries and Gingival Evaluation in Children with Congenital Heart Disease. 61
30034670 2018
20
The relationship between subjective oral health and dental fear in Korean adolescents. 61
29349351 2017
21
Oral health of youth housed in socio-educational centers of the Juvenile Penal Area of the Province of Córdoba, Argentina. 61
29750237 2017
22
A report on the clinical-pathological correlations of 788 gingival lesion. 61
29053652 2017
23
Metagenomic Analysis of Gingival Sulcus Microbiota and Pathogenesis of Periodontitis Associated with Type 2 Diabetes Mellitus. 61
29063339 2017
24
Association between periodontal disease and polycystic ovary syndrome: a systematic review. 61
28275229 2017
25
Efficacy of Milk as a Desensitizing Agent for the Treatment of Sensitivity Following Scaling and Root Planing. 61
28839408 2017
26
Assessment of Vitamin B12 and Its Correlation with Dental Caries and Gingival Diseases in 10- to 14-year-old Children: A Cross-sectional Study. 61
28890613 2017
27
The Salivary Microbiome and Oral Cancer Risk: a Pilot Study in Fanconi Anemia. 61
27827319 2017
28
Factors associated with the risk of gingival disease in patients with rheumatoid arthritis. 61
29023518 2017
29
A cross-sectional, clinical study to evaluate mobility of teeth during pregnancy using periotest. 61
28393811 2017
30
Innovative use of laterally positioned periosteal pedicle graft for coverage of gingivitis artefacta. 61
29238148 2016
31
Ultrastructural changes in epithelial cells of rats exposed to low concentration of hydrogen sulfide for 50 days. 61
27736270 2016
32
Oral Health and Oral Contraceptive - Is it a Shadow behind Broad Day Light? A Systematic Review. 61
28050520 2016
33
Angiosarcoma: A Case Report of Gingival Disease with Both Palatine Tonsils Localization. 61
27746875 2016
34
Dental needs of intellectualy disabled children attending six special educational facilities in Cape Town. 61
27245538 2016
35
Genomic analysis of gum disease and hypertrichosis in foxes. 61
27323055 2016
36
Desquamative gingivitis as only presenting sign of mucous membrane pemphigoid. 61
27563211 2016
37
Oral health needs of athletes with intellectual disability in Eastern Europe: Poland, Romania and Slovenia. 61
26601920 2016
38
Isolated gingival overgrowths: A review of case series. 61
27307683 2016
39
Treatment needs and predictive capacity of explanatory variables of oral disease in young athletes with an intellectual disability in Europe and Eurasia. 61
26949233 2016
40
[Comparative analysis of 6 kinds of bacteria in the subgingival plaque in different types of patients with periodontal diseases]. 61
26598191 2015
41
Antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against Fusobacterium nucleatum and in vitro plaques. 61
26591620 2015
42
Gingival enlargements: Differential diagnosis and review of literature. 61
26380825 2015
43
Gingival condition and tooth-brushing behavior after alcohol consumption. 61
25251783 2015
44
Relationship between xerostomia and gingival condition in young adults. 61
24697562 2015
45
Comparison of Levels of Salivary Cytokines in Diabetic and Nondiabetic Puerto Rican Children: A Case-control Pilot Study. 61
25685970 2015
46
Effect of oral curcuma gel in gingivitis management - a pilot study. 61
25654020 2014
47
Sarcoidosis presenting as isolated gingival enlargement: a rare case entity. 61
25584337 2014
48
Oral health status and treatment needs among primary school going children in Nagrota Bagwan block of Kangra, Himachal Pradesh. 61
25624634 2014
49
Gingival diseases in childhood - a review. 61
25478471 2014
50
Salivary biomarkers associated with gingivitis and response to therapy. 61
24502627 2014

Variations for Gingival Disease

Expression for Gingival Disease

Search GEO for disease gene expression data for Gingival Disease.

Pathways for Gingival Disease

Pathways related to Gingival Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 TNFSF11 TNF TIMP1 SOS1 SIGLEC5 SERPINA3
2
Show member pathways
13.84 TNFSF11 TNF TIMP1 SOS1 IL6 IL1B
3
Show member pathways
13.69 TNFSF11 TNF TIMP1 SOS1 SMARCA2 IL6
4
Show member pathways
13.39 TNFSF11 TNF TIMP1 SOS1 IL6 IL1B
5
Show member pathways
13.32 TNFSF11 TNF TIMP1 SOS1 MMP1 IL6
6
Show member pathways
13.31 TNFSF11 TNF TIMP1 IL6 IL1B CXCL8
7
Show member pathways
12.96 TNF SOS1 IL6 IL1B CXCL8 CD4
8
Show member pathways
12.63 TNF SOS1 IL6 IL1B CD4
9
Show member pathways
12.56 TNF TIMP1 SOS1 IL6 IL1B CD4
10
Show member pathways
12.35 TNF IL6 CXCL8 CCR6
11
Show member pathways
12.35 TNF MMP1 IL6 IL1B CXCL8
12
Show member pathways
12.34 TNF SOS1 IL6 IL1B CXCL8
13
Show member pathways
12.34 TNF SERPINA3 IL6 IL1B CRP
14 12.32 TNF IL6 IL1B CXCL8
15
Show member pathways
12.29 TNF TIMP1 IL6 IL1B CXCL8
16 12.26 TNF IL6 IL1B CXCL8
17 12.22 TNF SOS1 MMP1 IL6
18
Show member pathways
12.22 TNF IL6 IL1B CXCL8
19 12.21 TNF IL6 IL1B CXCL8
20
Show member pathways
12.21 TNF SOS1 IL6 IL1B CXCL8
21
Show member pathways
12.09 TNF IL6 IL1B CD4
22 12.05 TNF IL6 IL1B CXCL8
23 12.05 TNF IL6 IL1B CXCL8
24 11.95 TNFSF11 TNF IL1B CXCL8
25 11.94 TNF IL6 IL1B CXCL8
26 11.93 TNF IL6 IL1B CXCL8
27 11.92 TNF IL6 IL1B CD4
28
Show member pathways
11.87 TNF TIMP1 MMP8 MMP1 ELANE
29 11.8 IL6 IL1B CXCL8
30 11.8 TNF IL1B CD4 CCR6
31 11.78 SMARCA2 ELANE CD4
32 11.77 TNF IL6 IL1B CXCL8
33
Show member pathways
11.77 TNFSF11 TIMP1 SOS1 IL6 CRP
34 11.75 TNF IL6 IL1B CD4
35 11.74 TNF IL6 IL1B
36 11.67 TIMP1 MMP1 CXCL8
37 11.59 TNF IL6 IL1B CXCL8
38 11.56 TNF IL6 ELANE
39 11.53 SOS1 MMP1 IL6 CXCL8
40
Show member pathways
11.52 TNF MMP1 IL6 IL1B CXCL8
41 11.51 TNF IL6 IL1B CXCL8
42 11.49 TNF TIMP1 MMP1 IL6 IL1B CXCL8
43 11.45 TNFSF11 TNF IL6 IL1B
44 11.45 TNF TIMP1 IL6 IL1B CXCL8
45 11.43 TNF IL6 IL1B
46 11.4 TNF IL6 IL1B
47 11.38 MMP1 IL6 CXCL8
48 11.34 TNF IL6 IL1B
49 11.33 TNF IL6 IL1B
50
Show member pathways
11.3 TIMP1 SOS1 CRP

GO Terms for Gingival Disease

Cellular components related to Gingival Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TNFSF11 TNF TIMP1 SERPINF2 SERPINA3 MMP8
2 extracellular region GO:0005576 9.47 TNFSF11 TNF TIMP1 SERPINF2 SERPINA3 MMP8
3 platelet alpha granule lumen GO:0031093 9.33 TIMP1 SERPINF2 SERPINA3

Biological processes related to Gingival Disease according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10 TNFSF11 TNF MMP8 IL6 IL1B CRP
2 inflammatory response GO:0006954 9.97 TNF SERPINA3 IL6 IL1B CXCL8 CRP
3 cellular protein metabolic process GO:0044267 9.96 TIMP1 MMP1 IL6 AMBN
4 positive regulation of protein phosphorylation GO:0001934 9.92 TNF IL1B FAM20A CD4
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 TNFSF11 TNF IL1B CD4
6 cellular response to lipopolysaccharide GO:0071222 9.91 TNF IL6 IL1B CXCL8
7 leukocyte migration GO:0050900 9.91 TNF SOS1 MMP1 IL1B ELANE
8 immune response GO:0006955 9.91 TNFSF11 TNF IL6 IL1B CXCL8 CD4
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 TNFSF11 TNF IL6 IL1B
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 TNFSF11 TNF IL6 IL1B
11 positive regulation of MAP kinase activity GO:0043406 9.83 TNFSF11 TNF ELANE
12 positive regulation of T cell proliferation GO:0042102 9.82 IL6 IL1B CD4
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.82 TNF MMP8 IL1B
14 humoral immune response GO:0006959 9.8 TNF IL6 CCR6
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 TNF MMP8 IL1B
16 extracellular matrix disassembly GO:0022617 9.76 TIMP1 MMP8 MMP1 ELANE
17 positive regulation of interleukin-6 production GO:0032755 9.73 TNF MMP8 IL6 IL1B
18 negative regulation of neurogenesis GO:0050768 9.71 TNF IL6 IL1B
19 positive regulation of smooth muscle cell proliferation GO:0048661 9.71 TNF SERPINF2 IL6 ELANE
20 positive regulation of chemokine biosynthetic process GO:0045080 9.67 TNF IL1B
21 regulation of neuroinflammatory response GO:0150077 9.66 MMP8 IL6
22 leukocyte migration involved in inflammatory response GO:0002523 9.65 ELANE CCR6
23 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL6 IL1B
24 regulation of establishment of endothelial barrier GO:1903140 9.64 TNF IL1B
25 tooth eruption GO:0044691 9.63 TNFSF11 FAM20A
26 positive regulation of fever generation GO:0031622 9.61 TNF IL1B
27 regulation of microglial cell activation GO:1903978 9.58 MMP8 IL6
28 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 TNF IL1B
30 negative regulation of chemokine biosynthetic process GO:0045079 9.56 IL6 ELANE
31 acute-phase response GO:0006953 9.56 SERPINF2 SERPINA3 IL6 CRP
32 positive regulation of JNK cascade GO:0046330 9.55 TNFSF11 TNF SERPINF2 MMP8 IL1B
33 negative regulation of lipid storage GO:0010888 9.5 TNF IL6 CRP
34 cytokine-mediated signaling pathway GO:0019221 9.28 TNFSF11 TNF TIMP1 SOS1 MMP1 IL6
35 positive regulation of neuroinflammatory response GO:0150078 9.26 TNF MMP8 IL6 IL1B

Molecular functions related to Gingival Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.26 TNF TIMP1 SERPINF2 ELANE
2 cytokine activity GO:0005125 9.1 TNFSF11 TNF TIMP1 IL6 IL1B CXCL8

Sources for Gingival Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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