Aliases & Classifications for Gingival Disease

MalaCards integrated aliases for Gingival Disease:

Name: Gingival Disease 12 15
Gingival Diseases 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1483
MeSH 44 D005882
UMLS 73 C0017563

Summaries for Gingival Disease

MalaCards based summary : Gingival Disease, also known as gingival diseases, is related to gingival overgrowth and gingivitis, and has symptoms including halitosis, snoring and tenderness of gums. An important gene associated with Gingival Disease is ANTXR2 (ANTXR Cell Adhesion Molecule 2), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. The drugs Zinc and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and kidney, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Gingival Disease

Diseases related to Gingival Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 gingival overgrowth 30.1 CTGF FAM20A MMP1 TGFB1 TIMP1
2 gingivitis 29.7 CD79A ELANE IL1B IL6 MMP8
3 tonsillitis 29.2 CD79A IL1B IL6
4 periodontitis 28.9 IL1B IL6 MMP1 MMP8 TIMP1
5 periodontal disease 28.8 CD79A ELANE IL1B IL6 MMP1 MMP8
6 rheumatoid arthritis 27.2 CD79A IL1B IL6 MMP1 TGFB1 TIMP1
7 alpha thalassemia-x-linked intellectual disability syndrome 10.7 SMARCA2 SMARCA4
8 tendinopathy 10.6 MMP1 MMP8
9 enamel erosion 10.5 GPI SMARCA2 SMARCA4
10 tooth erosion 10.5 GPI SMARCA2 SMARCA4
11 recurrent corneal erosion 10.5 IL1B IL6
12 bagassosis 10.5 IL1B IL6
13 bone deterioration disease 10.5 IL1B MMP1 TIMP1
14 carotid artery disease 10.4 MMP1 MMP8 TIMP1
15 teeth hard tissue disease 10.4 FAM20A GPI SMARCA2
16 chronic follicular conjunctivitis 10.4 CD79A IL1B
17 giant hemangioma 10.4 SERPINF2 TGFB1
18 pulpitis 10.3 IL1B IL6 MMP1
19 aggressive periodontitis 10.3 IL1B IL6 MMP8
20 preterm premature rupture of the membranes 10.3 IL6 MMP1 MMP8
21 bacterial meningitis 10.3 IL1B IL6 MMP8
22 joint disorders 10.3 IL1B IL6 TIMP1
23 uremic pruritus 10.3 IL1B IL6
24 mid-dermal elastolysis 10.3 ELANE TIMP1
25 mouth disease 10.3 IL1B IL6 MMP8
26 bronchiolitis obliterans 10.2 IL6 MMP8 TIMP1
27 synovitis 10.2 IL1B IL6 MMP1
28 fibromatosis, gingival, 1 10.2 MMP1 SOS1 TGFB1
29 central nervous system tuberculosis 10.2 ELANE IL1B TIMP1
30 inguinal hernia 10.2 IL6 MMP1 TIMP1
31 funisitis 10.1 IL1B IL6
32 periodontitis, chronic 10.1 IL1B IL6 MMP1 MMP8
33 laryngitis 10.1 IL1B IL6 TGFB1
34 kidney hypertrophy 10.0 CTGF TGFB1
35 idiopathic neutropenia 10.0 IL1B IL6 TGFB1
36 prostatitis 10.0 IL1B IL6 TGFB1
37 acute respiratory distress syndrome 10.0 ELANE IL1B IL6
38 appendicitis 10.0 IL1B IL6 MMP8 TIMP1
39 nephrogenic systemic fibrosis 10.0 CTGF TGFB1 TIMP1
40 pneumoconiosis 10.0 IL1B IL6 TGFB1
41 autoinflammation, lipodystrophy, and dermatosis syndrome 10.0 ELANE IL1B IL6
42 glossitis 10.0 IL1B IL6
43 diabetic foot ulcers 10.0 IL6 TGFB1 TIMP1
44 vitreoretinopathy, neovascular inflammatory 10.0 CTGF TGFB1 TIMP1
45 chronic fatigue syndrome 10.0 IL1B IL6 TGFB1
46 biliary atresia 10.0 CTGF TGFB1 TIMP1
47 osteosclerotic myeloma 10.0 CD79A IL1B IL6
48 primary amebic meningoencephalitis 9.9 CD79A IL1B IL6
49 commensal bacterial infectious disease 9.9 CD79A IL1B IL6
50 polyclonal hypergammaglobulinemia 9.9 CD79A IL6

Graphical network of the top 20 diseases related to Gingival Disease:



Diseases related to Gingival Disease

Symptoms & Phenotypes for Gingival Disease

UMLS symptoms related to Gingival Disease:


halitosis, snoring, tenderness of gums

MGI Mouse Phenotypes related to Gingival Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 TGFB1 TIMP1 SOS1 IL6 CD79A CTGF
2 cardiovascular system MP:0005385 10.1 SOS1 TGFB1 TIMP1 IL1B ANTXR2 IL6
3 immune system MP:0005387 10.1 SOS1 TGFB1 TIMP1 ANTXR2 IL6 CD79A
4 mortality/aging MP:0010768 10.03 SOS1 TGFB1 TIMP1 IL1B ANTXR2 IL6
5 neoplasm MP:0002006 9.85 TGFB1 TIMP1 IL6 CD79A MMP1 ELANE
6 respiratory system MP:0005388 9.5 TGFB1 TIMP1 IL6 CTGF FAM20A GPI
7 skeleton MP:0005390 9.28 SOS1 TGFB1 TIMP1 IL1B IL6 CTGF

Drugs & Therapeutics for Gingival Disease

Drugs for Gingival Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 442)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-66-6 23994
2
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 9004-61-9 53477741
3
Menthol Approved Phase 4,Phase 3,Not Applicable,Early Phase 1 2216-51-5 16666
4
Metformin Approved Phase 4,Phase 2,Phase 3 657-24-9 14219 4091
5
Ciprofloxacin Approved, Investigational Phase 4,Phase 1,Not Applicable 85721-33-1 2764
6
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 564-25-0 54671203
7
Azithromycin Approved Phase 4,Phase 2,Not Applicable 83905-01-5 55185 447043
8
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
9 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
10
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 22916-47-8 4189
11
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 443-48-1 4173
12 sodium fluoride Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 7681-49-4
13
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Not Applicable 103-90-2 1983
14
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 26787-78-0 33613
15
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
16
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 55-56-1 9552079 2713
17
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
18
Ethanol Approved Phase 4,Phase 3,Phase 2,Not Applicable 64-17-5 702
19
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
20
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 51-43-4 5816
21
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
22
Triclosan Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 3380-34-5 5564
23
Hexetidine Approved, Investigational Phase 4 141-94-6
24
Polyestradiol phosphate Approved Phase 4 28014-46-2
25
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 329-65-7 838
26
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 137-58-6 3676
27
Simvastatin Approved Phase 4,Phase 2,Phase 3 79902-63-9 54454
28
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
29
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
30
Zoledronic acid Approved Phase 4 118072-93-8 68740
31
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 81103-11-9 84029
32
Minocycline Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 10118-90-8 5281021
33
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-78-2 2244
34
Alendronate Approved Phase 4,Phase 2,Phase 3 121268-17-5, 66376-36-1 2088
35
Thymol Approved Phase 4,Not Applicable 89-83-8 6989
36
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
37
Montelukast Approved Phase 4 158966-92-8 5281040
38
Ibuprofen Approved Phase 4,Phase 2,Phase 3,Not Applicable 15687-27-1 3672
39
Silicon Approved, Investigational Phase 4,Phase 1,Phase 2 7440-21-3 4082203
40
Mepivacaine Approved, Vet_approved Phase 4,Not Applicable 96-88-8 4062
41
Prilocaine Approved Phase 4 721-50-6 4906
42
Edetic Acid Approved, Vet_approved Phase 4,Not Applicable 60-00-4, 62-33-9 6049
43
Methyl salicylate Approved, Vet_approved Phase 4,Not Applicable 119-36-8 4133
44
Cetylpyridinium Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7773-52-6
45
Coal tar Approved Phase 4,Phase 3,Not Applicable 8007-45-2
46
Hydrogen peroxide Approved, Vet_approved Phase 4,Not Applicable 7722-84-1 784
47
Alginic acid Approved, Investigational Phase 4 9005-32-7
48
Pentetic acid Approved Phase 4,Not Applicable 67-43-6
49
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
50
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0

Interventional clinical trials:

(show top 50) (show all 1219)
# Name Status NCT ID Phase Drugs
1 Clinical Investigation of the Effects of Colgate Total Toothpaste as Compared to a Matching Placebo on Periodontal Disease and Systemic Inflammatory Markers Unknown status NCT02670135 Phase 4 Triclosan Containing Toothpaste;Triclosan Free Toothpaste
2 The Treatment of Periodontal Diseases Unknown status NCT01318928 Phase 4 Metronidazol
3 Norplant and Irregular Bleeding/Spotting Unknown status NCT00064766 Phase 4 doxycycline
4 Effect of Actonel on Periodontal Health of Postmenopausal Women Unknown status NCT00594334 Phase 4 Risedronate
5 The Efficacy of Cyanoacrylate Adhesive (PeriAcryl®90 HV) in Periodontal Wound Healing Unknown status NCT02826109 Phase 4
6 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
7 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
8 Methodology Antiseptic Application, Influence on Oral Biofilm. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
9 Efficacy and Safety of a Commercially Available Injectable Hyaluronic Acid Dental Filler for Periodontal Pockets Unknown status NCT02391974 Phase 4
10 Metronidazole and Amoxicillin for the Treatment of Type 2 Diabetic Subjects With Periodontitis Unknown status NCT02135952 Phase 4 MTZ+AMX
11 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
12 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
13 Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis Unknown status NCT00297531 Phase 4
14 SRP in Combination With PERIOWAVE in Comparison to SRP Alone in Chronic Periodontitis Unknown status NCT00296881 Phase 4
15 Pinhole Surgical Technique With And Without Use Of Buttons For Treatment Of Multiple Gingival Recessions: RCT Unknown status NCT02632968 Phase 4
16 Laser De-epithelialization for Epithelial Exclusion in Root Coverage Procedure: a Clinical Study Unknown status NCT02626117 Phase 4
17 Platelet Rich Fibrin in the Treatment of Palatal Wounds Unknown status NCT02438046 Phase 4
18 Connective Tissue Graft Versus Mucograft Collagen Matrix for Coverage of Multiple Gingival Recession Defects Unknown status NCT01440426 Phase 4
19 Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment Unknown status NCT02839421 Phase 4 Scaling and Root Planing combined with moxifloxacin
20 Evaluation of a Lateral Window Technique Augmentation for Maxillary Sinus Using Ultrasound Activated Pins Unknown status NCT02449707 Phase 4
21 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). Unknown status NCT01778699 Phase 4
22 Effect of Probiotic Lozenges on Halitosis in Patients With Chronic Periodontitis Unknown status NCT02789436 Phase 4 L. reuteri Prodentis® lozenges
23 Adhesion of Connective Tissue Around Laser-treated Abutments for Dental Implants - Clinical Trial in Humans Unknown status NCT01954485 Phase 4
24 Relationship of Periodontal Disease Treatment and Type 2 Diabetes Mellitus in the Gullah Population Completed NCT01798225 Phase 4 Placebo;Doxycycline
25 Conventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matrix Derivative and Anorganic Bovine Bone - a Randomized Controlled Clinical Trial. Completed NCT02102360 Phase 4
26 Long-term Safety of Minocycline in Patients With Gum Disease Completed NCT00668746 Phase 4 Minocycline HCl microspheres
27 EMD and/or Bone Substitute for the Treatment of Class II Furcations Completed NCT02474498 Phase 4 EMD
28 Pediatric Study to Access Pharmacokinetics and Safety of Oraqix Gel Completed NCT01591616 Phase 4 lidocaine and prilocaine
29 Efficacy of Two Oral Hygiene Regimens in the Reduction of Dentin Hypersensitivity After Periodontal Treatment Completed NCT02461030 Phase 4 In-office and at home Colgate sensitive pro-relief - CSPR;In-office Villevie® prophy paste + Colgate Toothpaste
30 Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy. Completed NCT02487186 Phase 4 Doxicicline
31 Study on Regenerative Treatment of Intra-bony Defects Completed NCT00757159 Phase 4
32 Melatonin as an Adjunctive Therapy for Chronic Periodontitis. Completed NCT03368430 Phase 4 Placebo
33 A Clinical Trial to Test the Effect of Experimental Mouth Rinse on Gum Disease Completed NCT02065414 Phase 4
34 Interaction Between Chlorhexidine and Fluoride Completed NCT02935322 Phase 4 0.12 % chlorhexidine + 0.2 % NaF mouthrinse;0.2 % NaF mouthrinse;0.12% chlorhexidine
35 A Clinical Trial to Study the Effect of Lycopene in Patients With Gum Disease and type2 Diabetes Mellitus Completed NCT02263352 Phase 4 Lycored soft gels Jagsonpal Pharma, Systemic 8mgms/day
36 Mechanical-chemical Gingival Therapy in Diabetics and/or Obese Completed NCT02123563 Phase 4
37 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs Completed NCT02515929 Phase 4
38 Photodynamic Therapy During Supportive Periodontal Therapy Completed NCT02666573 Phase 4
39 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
40 Treatment of Periodontitis by Conventional 4 Weekly Sections or Within 24 Hours Completed NCT02215460 Phase 4 FMS chlorhexidine rinse;FMS placebo rinse;FMS azithromycin tablets;FMS placebo tablets;QS azithromycin tablets;QS placebo tablets;QS chlorhexidine rinse;QS placebo rinse
41 Host Modulatory Effects of β-glucan on Localized Aggressive Periodontitis Completed NCT02402296 Phase 4 β-1,3/1,6-D-glucan
42 Effect of Arthrospira Platensis (Spirulina) as an Adjunct to Scaling and Root Planing on Salivary Antioxidant Levels in Chronic Periodontitis Subjects Completed NCT02886676 Phase 4 Spirulina capsules
43 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing Completed NCT02197260 Phase 4 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days
44 Evaluation of Photodynamic Treatment FOTOSAN® Efficacy in Periodontology Completed NCT02030470 Phase 4
45 Impact of Periodontal Treatment on Serum Levels of Hepcidin and Hemoglobin Completed NCT02641210 Phase 4 Albendazole
46 Effects of the Variation in the Time of Systemic Administration of Metronidazole and Amoxicillin Associated to the Non-surgical Therapy of Chronic Periodontitis. Completed NCT01211223 Phase 4 Administration of Metronidazole plus Amoxicillin
47 Effect of Scaling and Root Planing Along With Topical Application of Commercially Available Curcuma Longa Gel on Superoxide Dismutase and Malondialdehyde Levels in Saliva of Chronic Periodontitis Patients Completed NCT02442453 Phase 4 Topical application of curenext gel;Placebo
48 Sodium Alendronate in Non Surgical Periodontal Therapy Completed NCT02470611 Phase 4 Sodium alendronate
49 DFDBA and Xenograft (Cerabone)TM With Decortication in Intrabony Defects Completed NCT02949557 Phase 4
50 Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients Completed NCT01647282 Phase 4 locally-applied minocycline HCl (1 mg)

Search NIH Clinical Center for Gingival Disease

Cochrane evidence based reviews: gingival diseases

Genetic Tests for Gingival Disease

Anatomical Context for Gingival Disease

MalaCards organs/tissues related to Gingival Disease:

41
Bone, Testes, Kidney, Heart, Ovary, Breast, Colon

Publications for Gingival Disease

Articles related to Gingival Disease:

(show all 35)
# Title Authors Year
1
Factors associated with the risk of gingival disease in patients with rheumatoid arthritis. ( 29023518 )
2017
2
Assessment of Vitamin B12 and Its Correlation with Dental Caries and Gingival Diseases in 10- to 14-year-old Children: A Cross-sectional Study. ( 28890613 )
2017
3
Angiosarcoma: A Case Report of Gingival Disease with Both Palatine Tonsils Localization. ( 27746875 )
2016
4
The antiplaque effect of herbal mouthwash in comparison to chlorhexidine in human gingival disease: a randomized placebo controlled clinical trial. ( 24698829 )
2014
5
Gingival disease and secretory immunoglobulin a in non-stimulated saliva in children. ( 21462892 )
2010
6
Sulcular sulfide monitoring: an indicator of early dental plaque-induced gingival disease. ( 16451765 )
2006
7
Differential gene expression of human beta-defensins (hBD-1, -2, -3) in inflammatory gingival diseases. ( 15836521 )
2005
8
A clinical trial of the effect of a mouth-rinse prepared with Lippia sidoides Cham essential oil in dogs with mild gingival disease. ( 12719020 )
2003
9
Gingival disease associated with a decorative crown. ( 11874059 )
2002
10
Factitial (self-induced) gingival disease: four case reports. ( 11820044 )
2001
11
An evaluation of a dentifrice containing salivary peroxidase elements for the control of gingival disease in patients with irradiated head and neck cancer. ( 8887803 )
1996
12
Serum responses of cats with periodontal/gingival disease to members of the genus Porphyromonas. ( 7548583 )
1995
13
Posttransplantation lymphoproliferative gingival disease. ( 7579379 )
1995
14
Serum antibody levels to oral microorganisms in children and young adults with relation to the severity of gingival disease. ( 1815198 )
1991
15
Socio-economic risk factors for gingival disease in children. ( 2637359 )
1989
16
A clinical and microbiologic examination of gingival disease in parapubescent females. ( 3489831 )
1986
17
Gingival disease in children--an emerging problem. ( 6954255 )
1982
18
The relationships between irregular teeth, plaque, calculus and gingival disease. A study of 300 subjects. ( 6928101 )
1980
19
The effect of 0.5% chlorhexidine gel on gingival disease--report of pilot study. ( 1071093 )
1975
20
Lymphocyte-fibroblast interaction in the pathogenesis of inflammatory gingival disease. ( 5087049 )
1972
21
Studies in dentifrices. 3. The prevalence of gingival disease in children 12-14 years of age in relation to toothbrushing by means of different dentifrices. ( 5273241 )
1970
22
Dental calculus and bacterial plaque and their relationship to gingival disease in 400 individuals. ( 5272470 )
1970
23
Gingival disease prevalence in mentally handicapped adults. The effects of an oral hygiene programme. ( 5260558 )
1969
24
The differential diagnosis of gingival disease with special reference to Vincent's infection. ( 5231147 )
1967
25
The differential diagnosis of gingival disease with special reference to Vincent's infection. ( 5945751 )
1966
26
Effect of geographic location and race on gingival disease in children. ( 13788544 )
1960
27
The effect of clorpactin on gingival disease; preliminary report. ( 13322423 )
1956
28
Gingival disease in the Virgin Islands. ( 15402122 )
1950
29
Gingival disease in relation to systemic disorders. ( 20291904 )
1947
30
Experimental investigation of parodontal disease; further clinical studies of sugar-cane gnawing in treatment of gingival disease. ( 18895814 )
1947
31
A basic approach to the problem of gingival disease. ( 20294315 )
1947
32
Gingival disease in postwar Italy (1945) gingivosis in hospitalized children in Naples. ( 20266565 )
1947
33
Gingival disease in postwar Italy (1945) prevalence of gingivitis in various age groups. ( 20260900 )
1947
34
Experimental investigations of parodontal disease; gnawing of sugar cane in the treatment of non-ulcerative gingival disease in man. ( 20294239 )
1947
35
A basic approach to the problems of gingival disease. ( 20292533 )
1947

Variations for Gingival Disease

Expression for Gingival Disease

Search GEO for disease gene expression data for Gingival Disease.

Pathways for Gingival Disease

Pathways related to Gingival Disease according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 CD79A ELANE GPI IL1B IL6 MMP1
2
Show member pathways
13.61 CD79A CTGF IL6 MMP1 MMP8 SOS1
3
Show member pathways
13.23 IL1B IL6 MMP1 SMARCA4 SOS1 TGFB1
4
Show member pathways
12.92 CD79A CTGF IL6 SOS1 TGFB1 TIMP1
5
Show member pathways
12.61 ELANE MMP1 MMP8 TGFB1 TIMP1
6
Show member pathways
12.54 CTGF IL1B IL6 TGFB1 TIMP1
7
Show member pathways
12.47 IL1B IL6 SOS1 TIMP1
8
Show member pathways
12.31 IL1B IL6 SOS1 TGFB1
9 11.95 IL6 MMP1 SOS1 TGFB1
10 11.89 IL1B IL6 TGFB1
11 11.82 IL1B IL6 TGFB1
12 11.79 IL1B IL6 TGFB1
13 11.77 IL1B IL6 TGFB1
14
Show member pathways
11.75 CTGF IL1B IL6 SOS1 TGFB1 TIMP1
15
Show member pathways
11.72 IL6 SOS1 TIMP1
16 11.68 IL6 MMP1 SMARCA4
17
Show member pathways
11.66 ELANE MMP1 MMP8 TIMP1
18 11.63 IL1B IL6 TGFB1
19 11.58 IL1B IL6 MMP1 TGFB1
20
Show member pathways
11.54 IL1B IL6 MMP1
21 11.41 IL1B IL6 MMP1 TGFB1 TIMP1
22 11.39 CTGF SOS1 TGFB1
23 11.36 IL1B IL6 TIMP1
24 11.34 IL1B IL6 TGFB1
25 11.31 CTGF ELANE IL6
26 11.16 IL6 MMP1 SOS1 TGFB1
27 11.06 IL1B IL6 TGFB1
28 10.93 MMP1 TIMP1
29 10.86 MMP1 TGFB1
30 10.82 CTGF IL1B IL6 TGFB1 TIMP1

GO Terms for Gingival Disease

Cellular components related to Gingival Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ANTXR2 CTGF ELANE FAM20A GPI IL1B
2 secretory granule GO:0030141 9.58 ELANE IL1B TGFB1
3 extracellular matrix GO:0031012 9.56 MMP1 MMP8 TGFB1 TIMP1
4 SWI/SNF complex GO:0016514 9.43 SMARCA2 SMARCA4
5 nBAF complex GO:0071565 9.37 SMARCA2 SMARCA4
6 extracellular space GO:0005615 9.36 CTGF ELANE FAM20A GPI IL1B IL6
7 platelet alpha granule lumen GO:0031093 9.33 SERPINF2 TGFB1 TIMP1
8 npBAF complex GO:0071564 9.32 SMARCA2 SMARCA4

Biological processes related to Gingival Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.93 IL1B IL6 SMARCA2 SMARCA4 TGFB1
2 positive regulation of cell proliferation GO:0008284 9.88 CTGF IL1B IL6 TGFB1 TIMP1
3 platelet degranulation GO:0002576 9.77 SERPINF2 TGFB1 TIMP1
4 negative regulation of cell growth GO:0030308 9.75 SMARCA2 SMARCA4 TGFB1
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.73 IL1B IL6 SMARCA4
6 regulation of signaling receptor activity GO:0010469 9.73 CTGF GPI IL1B IL6 TGFB1 TIMP1
7 positive regulation of protein phosphorylation GO:0001934 9.71 CTGF FAM20A IL1B TGFB1
8 response to estradiol GO:0032355 9.7 CTGF GPI TGFB1
9 response to organic substance GO:0010033 9.69 SERPINF2 TGFB1 TIMP1
10 positive regulation of JNK cascade GO:0046330 9.63 CTGF IL1B SERPINF2
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.61 ELANE IL6 SERPINF2
12 positive regulation of histone acetylation GO:0035066 9.58 IL1B TGFB1
13 cell activation GO:0001775 9.57 TGFB1 TIMP1
14 leukocyte migration GO:0050900 9.55 ELANE IL1B MMP1 SOS1 TGFB1
15 positive regulation of collagen biosynthetic process GO:0032967 9.5 CTGF SERPINF2 TGFB1
16 positive regulation of immunoglobulin secretion GO:0051024 9.49 GPI IL6
17 negative regulation of chemokine biosynthetic process GO:0045079 9.37 ELANE IL6
18 extracellular matrix disassembly GO:0022617 9.26 ELANE MMP1 MMP8 TIMP1
19 cytokine-mediated signaling pathway GO:0019221 9.1 IL1B IL6 MMP1 SOS1 TGFB1 TIMP1
20 positive regulation of transcription by RNA polymerase II GO:0045944 10.02 IL1B IL6 SERPINF2 SMARCA2 SMARCA4 TGFB1

Molecular functions related to Gingival Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.43 ELANE SERPINF2 TIMP1
2 cytokine activity GO:0005125 9.35 GPI IL1B IL6 TGFB1 TIMP1
3 hydrolase activity, acting on acid anhydrides GO:0016817 9.16 SMARCA2 SMARCA4
4 growth factor activity GO:0008083 9.02 CTGF GPI IL6 TGFB1 TIMP1

Sources for Gingival Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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