MCID: GNG025
MIFTS: 47

Gingival Fibromatosis

Categories: Genetic diseases, Oral diseases, Rare diseases

Aliases & Classifications for Gingival Fibromatosis

MalaCards integrated aliases for Gingival Fibromatosis:

Name: Gingival Fibromatosis 12 29 6 15
Hereditary Gingival Fibromatosis 12 58 71
Hereditary Gingival Hyperplasia 12 58
Autosomal Dominant Gingival Fibromatosis 58
Autosomal Dominant Gingival Hyperplasia 58
Fibromatosis, Gingival, Hereditary 44

Characteristics:

Orphanet epidemiological data:

58
hereditary gingival fibromatosis
Inheritance: Autosomal dominant; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare odontological diseases


External Ids:

Disease Ontology 12 DOID:0060466
MeSH 44 C562884
SNOMED-CT 67 109620006
ICD10 via Orphanet 33 K06.1
UMLS via Orphanet 72 C0399440
Orphanet 58 ORPHA2024
UMLS 71 C0399440

Summaries for Gingival Fibromatosis

Disease Ontology : 12 A gingival overgrowth characterized by benign, slowly progressive, nonhemorrhagic, fibrous enlargement of the oral masticatory mucosa.

MalaCards based summary : Gingival Fibromatosis, also known as hereditary gingival fibromatosis, is related to fibromatosis, gingival, 1 and amelogenesis imperfecta, type ig. An important gene associated with Gingival Fibromatosis is SOS1 (SOS Ras/Rac Guanine Nucleotide Exchange Factor 1), and among its related pathways/superpathways are GPCR Pathway and Integrin Pathway. Affiliated tissues include tongue and pituitary, and related phenotypes are gingival overgrowth and gingival fibromatosis

Related Diseases for Gingival Fibromatosis

Diseases in the Gingival Fibromatosis family:

Fibromatosis, Gingival, 1 Fibromatosis, Gingival, 2
Fibromatosis, Gingival, 3 Fibromatosis, Gingival, 4
Fibromatosis, Gingival, 5

Diseases related to Gingival Fibromatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 fibromatosis, gingival, 1 32.9 TGFB1 SOS1 SERPINH1 REST MMP2 MMP1
2 amelogenesis imperfecta, type ig 32.6 GINGF4 GINGF3 GINGF2
3 fibromatosis 32.3 SOS1 REST GINGF3
4 gingival overgrowth 30.8 TIMP1 TGFB1 SOS1 MMP3 MMP2 MMP1
5 periodontitis 30.8 TIMP1 MMP3 MMP2 MMP1
6 gingival hypertrophy 30.5 TIMP2 SOS1 MMP3
7 gingival disease 30.3 TIMP1 TGFB1 SOS1 MMP1 FN1
8 myopia 29.6 TIMP2 TIMP1 TGFB1 MMP3 MMP2 MMP1
9 hypertrichosis, congenital generalized, with or without gingival hyperplasia 11.9
10 fibromatosis, gingival, with progressive deafness 11.8
11 fibromatosis, gingival, 2 11.7
12 fibromatosis, gingival, 4 11.7
13 zimmermann-laband syndrome 1 11.6
14 ramon syndrome 11.6
15 fibromatosis, gingival, 5 11.6
16 zimmermann-laband syndrome 11.5
17 fibromatosis, gingival, 3 11.5
18 fibromatosis, gingival, with distinctive facies 11.5
19 oculocerebral syndrome with hypopigmentation 11.2
20 rutherfurd syndrome 11.1
21 overgrowth syndrome 10.8
22 hypertrichosis 10.6
23 aggressive periodontitis 10.4
24 keloid disorder 10.4 TGFB1 SERPINH1
25 lentigo maligna melanoma 10.4 TIMP1 MMP2
26 villonodular synovitis 10.3 SOS1 MMP1
27 superior limbic keratoconjunctivitis 10.3 MMP3 MMP1
28 light chain deposition disease 10.3 MMP2 MMP1
29 coronary artery aneurysm 10.3 MMP3 MMP1
30 cherubism 10.3
31 diffuse pulmonary fibrosis 10.3 SERPINH1 FN1
32 hypertrophic scars 10.3 TIMP1 TGFB1 MMP2
33 scleredema adultorum 10.3 MMP1 FN1
34 odontogenic myxoma 10.3 MMP2 MMP1
35 nephrogenic systemic fibrosis 10.3 TIMP1 TGFB1 CCN2
36 collagenous colitis 10.3 TIMP1 MMP1 CCN2
37 hair whorl 10.3
38 urethral stricture 10.3 TGFB1 CCN2
39 ocular cicatricial pemphigoid 10.3 TGFB1 SERPINH1 CCN2
40 cholecystolithiasis 10.3 TGFB1 CCN2
41 tendinosis 10.2 TIMP1 MMP3 MMP1
42 localized scleroderma 10.2 TGFB1 MMP1 CCN2
43 fungal keratitis 10.2 TIMP2 TIMP1
44 spastic entropion 10.2 MMP3 MMP2 MMP1
45 bone deterioration disease 10.2 TIMP1 MMP3 MMP1
46 biliary atresia 10.2 TIMP1 TGFB1 CCN2
47 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
48 amelogenesis imperfecta 10.2
49 growth hormone deficiency 10.2
50 lipodermatosclerosis 10.2 TIMP2 MMP1

Graphical network of the top 20 diseases related to Gingival Fibromatosis:



Diseases related to Gingival Fibromatosis

Symptoms & Phenotypes for Gingival Fibromatosis

Human phenotypes related to Gingival Fibromatosis:

58
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 gingival overgrowth 58 Very frequent (99-80%)
2 gingival fibromatosis 58 Very frequent (99-80%)

GenomeRNAi Phenotypes related to Gingival Fibromatosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CAMK4 ITGA2 MMP2 SOS1 TGFB1 TIMP1

MGI Mouse Phenotypes related to Gingival Fibromatosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.32 CCN2 FN1 KCNQ1 MMP2 REST SERPINH1

Drugs & Therapeutics for Gingival Fibromatosis

Search Clinical Trials , NIH Clinical Center for Gingival Fibromatosis

Cochrane evidence based reviews: fibromatosis, gingival, hereditary

Genetic Tests for Gingival Fibromatosis

Genetic tests related to Gingival Fibromatosis:

# Genetic test Affiliating Genes
1 Gingival Fibromatosis 29

Anatomical Context for Gingival Fibromatosis

MalaCards organs/tissues related to Gingival Fibromatosis:

40
Tongue, Pituitary

Publications for Gingival Fibromatosis

Articles related to Gingival Fibromatosis:

(show top 50) (show all 358)
# Title Authors PMID Year
1
A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1. 6 61
11868160 2002
2
Association of mutation in PTPN14 gene and gingival fibromatosis with distinctive facies: a novel finding in whole exome sequencing. 61
33491997 2021
3
Local Mucosal Flap for the Treatment of Gingival Defect After Gingival Fibromatosis Excision. 61
33437556 2020
4
Activated KCNQ1 channel promotes fibrogenic response in hereditary gingival fibromatosis via clustering and activation of Ras. 61
33381870 2020
5
Hereditary gingival fibromatosis in children: a systematic review of the literature. 61
33188467 2020
6
A Rare Case of non Syndromic Congenital Idiopathic Gingival Fibromatosis: Electrosurgical Management. 61
33181851 2020
7
Hereditary gingival fibromatosis associated with the missense mutation of the KCNK4 gene. 61
32981868 2020
8
Idiopathic gingival fibromatosis with massive gingival overgrowth: A rare case report. 61
32831513 2020
9
Son of Sevenless-1 genetic status in an Indian family with nonsyndromic hereditary gingival fibromatosis. 61
32773981 2020
10
Nonsyndromic hereditary gingival fibromatosis: Characterization of a family and review of genetic etiology. 61
32413193 2020
11
Syndromes with gingival fibromatosis: A systematic review. 61
32335995 2020
12
Unusual clinical and histologic findings in a child with mixed dentition with hereditary gingival fibromatosis: a case report. 61
32154139 2020
13
[Hereditary gingival fibromatosis: a three-generation case report]. 61
32037776 2020
14
Generalized hereditary gingival fibromatosis in a child: clinical, histopathological and therapeutic aspects. 61
32039068 2020
15
Gingival fibromatosis with congenital hypertrichosis. 61
31983850 2020
16
Enamel renal syndrome: A novel homozygous FAM20A founder mutation in 5 new Brazilian families. 61
30394349 2019
17
Antifibrotic Potential of MiR-335-3p in Hereditary Gingival Fibromatosis. 61
31323181 2019
18
Exomic and transcriptomic alterations of hereditary gingival fibromatosis. 61
30907493 2019
19
Ramon Syndrome- A Rare Form of Cherubism. 61
31909027 2019
20
Genetic and developmental disorders of the oral mucosa: Epidemiology; molecular mechanisms; diagnostic criteria; management. 61
31090139 2019
21
Zimmermann-Laband-1 Syndrome: Clinical, Histological, and Proteomic Findings of a 3-Year-Old Patient with Hereditary Gingival Fibromatosis. 61
31261938 2019
22
Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis. 61
31130610 2019
23
Zimmermann-Laband syndrome: Clinical and cytogenetic study in two related patients. 61
31275518 2019
24
Rare case report of idiopathic gingival fibromatosis in childhood and its management. 61
30674497 2019
25
Fibroblasts from recurrent fibrotic overgrowths reveal high rate of proliferation in vitro - findings from the study of hereditary and idiopathic gingival fibromatosis. 61
30231645 2019
26
Towards the targeted management of hereditary gingival fibromatosis. 61
30396478 2018
27
TIMP-1 association with collagen type I overproduction in hereditary gingival fibromatosis. 61
29989318 2018
28
Hereditary Gingival Fibromatosis: a Case Report with Seven-Year Follow-up. 61
30510301 2018
29
Nonsyndromic Gingival Fibromatosis: A Rare Case Report. 61
30131651 2018
30
Screening for germline KCNQ1 and KCNE2 mutations in a set of somatotropinoma patients. 61
29703730 2018
31
Expression of CD163 in hereditary gingival fibromatosis: A possible association with TGF-β1. 61
29325232 2018
32
Gene expression profiling and bioinformatics analysis of hereditary gingival fibromatosis. 61
29435271 2018
33
The Effect of MMP-13, MMP-12, and AMBN on Gingival Enlargement and Root Deformation In a New Type of Gingival Fibromatosis. 61
28937892 2018
34
The Role of KCNQ1 Mutations and Maternal Beta Blocker Use During Pregnancy in the Growth of Children With Long QT Syndrome. 61
29740400 2018
35
Nephrocalcinosis in Amelogenesis Imperfecta Caused by the FAM20A Mutation. 61
29439260 2018
36
Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis. 61
29097701 2017
37
Analysis of mutations in the SOS-1 gene in two Polish families with hereditary gingival fibromatosis. 61
28425619 2017
38
Squamous cell carcinoma arising in familial gingival fibromatosis-a rare case report. 61
29026519 2017
39
Craniosynostosis in patients with RASopathies: Accumulating clinical evidence for expanding the phenotype. 61
28650561 2017
40
Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients. 61
28433619 2017
41
REST Final-Exon-Truncating Mutations Cause Hereditary Gingival Fibromatosis. 61
28686854 2017
42
Periodontal disease and FAM20A mutations. 61
28298625 2017
43
Gingival fibromatosis with hypertrichosis syndrome: Case series of rare syndrome. 61
28836540 2017
44
Hereditary gingival fibromatosis: Characteristics and treatment approach. 61
28469831 2017
45
Unusual presentation of familial gingival fibromatosis among male siblings. 61
29398861 2017
46
Giant maxillary gingival fibromatosis. 61
27791424 2017
47
FAM20A Gene Mutation: Amelogenesis or Ectopic Mineralization? 61
28515694 2017
48
Genetic analysis of hereditary gingival fibromatosis using whole exome sequencing and bioinformatics. 61
27614106 2017
49
On the Cellular and Molecular Mechanisms of Drug-Induced Gingival Overgrowth. 61
28868093 2017
50
Modeling RASopathies with Genetically Modified Mouse Models. 61
27924582 2017

Variations for Gingival Fibromatosis

ClinVar genetic disease variations for Gingival Fibromatosis:

6 (show top 50) (show all 175)
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 SOS1 NM_005633.3(SOS1):c.3248dup (p.Arg1084fs) Duplication Pathogenic 12868 rs387906518 2:39222361-39222362 2:38995220-38995221
2 SOS1 NM_005633.3(SOS1):c.1654A>G (p.Arg552Gly) SNV Pathogenic 12871 rs137852814 2:39249915-39249915 2:39022774-39022774
3 SOS1 NM_005633.3(SOS1):c.1656G>T (p.Arg552Ser) SNV Pathogenic 40684 rs267607079 2:39249913-39249913 2:39022772-39022772
4 SOS1 NM_005633.3(SOS1):c.797C>A (p.Thr266Lys) SNV Pathogenic 12869 rs137852812 2:39278352-39278352 2:39051211-39051211
5 SOS1 NM_005633.3(SOS1):c.2536G>A (p.Glu846Lys) SNV Pathogenic 40706 rs397517159 2:39234309-39234309 2:39007168-39007168
6 SOS1 NM_005633.3(SOS1):c.1656G>C (p.Arg552Ser) SNV Pathogenic 12872 rs267607079 2:39249913-39249913 2:39022772-39022772
7 SOS1 NM_005633.3(SOS1):c.1642A>C (p.Ser548Arg) SNV Pathogenic 40678 rs397517149 2:39249927-39249927 2:39022786-39022786
8 SOS1 NM_005633.3(SOS1):c.1867T>A (p.Phe623Ile) SNV Likely pathogenic 636262 rs727505093 2:39241979-39241979 2:39014838-39014838
9 REST NM_005612.5(REST):c.2413del (p.Leu805fs) Deletion Likely pathogenic 427773 rs1553904346 4:57797434-57797434 4:56931268-56931268
10 REST NM_005612.5(REST):c.2865_2866del (p.Asn958fs) Deletion Likely pathogenic 427771 rs1553904481 4:57797889-57797890 4:56931723-56931724
11 REST NM_005612.5(REST):c.1310T>A (p.Leu437Ter) SNV Likely pathogenic 427772 rs1553904077 4:57796334-57796334 4:56930168-56930168
12 ZNF862 NM_001099220.3(ZNF862):c.2812G>A (p.Ala938Thr) SNV Likely pathogenic 870571 7:149559061-149559061 7:149861972-149861972
13 SOS1 NM_005633.3(SOS1):c.*1303C>A SNV Uncertain significance 335998 rs115153488 2:39211662-39211662 2:38984521-38984521
14 SOS1 NM_005633.3(SOS1):c.*2503_*2506dup Duplication Uncertain significance 335980 rs886056007 2:39210458-39210459 2:38983317-38983318
15 SOS1 NM_005633.3(SOS1):c.*1094_*1097delTTTG Microsatellite Uncertain significance 336000 rs886056016 2:39211868-39211871 2:38984727-38984730
16 SOS1 NM_005633.3(SOS1):c.899G>A (p.Arg300Gln) SNV Uncertain significance 336021 rs754374236 2:39262607-39262607 2:39035466-39035466
17 SOS1 NM_005633.3(SOS1):c.2789T>C (p.Phe930Ser) SNV Uncertain significance 336018 rs886056024 2:39233555-39233555 2:39006414-39006414
18 SOS1 NM_005633.3(SOS1):c.*909G>A SNV Uncertain significance 336001 rs147219108 2:39212056-39212056 2:38984915-38984915
19 SOS1 NM_005633.3(SOS1):c.1989A>C (p.Ile663=) SNV Uncertain significance 139227 rs587781172 2:39241082-39241082 2:39013941-39013941
20 SOS1 NM_005633.3(SOS1):c.2121T>C (p.Asp707=) SNV Uncertain significance 336019 rs571408451 2:39240647-39240647 2:39013506-39013506
21 SOS1 NM_005633.3(SOS1):c.*4265A>G SNV Uncertain significance 335963 rs377303107 2:39208700-39208700 2:38981559-38981559
22 SOS1 NM_005633.3(SOS1):c.3724dup (p.Ser1242fs) Duplication Uncertain significance 631861 rs1558454973 2:39213242-39213243 2:38986101-38986102
23 SOS1 NM_005633.4(SOS1):c.2344A>G (p.Ile782Val) SNV Uncertain significance 931054 2:39239313-39239313 2:39012172-39012172
24 SOS1 NM_005633.4(SOS1):c.511-6_511-5del Deletion Uncertain significance 931188 2:39281969-39281970 2:39054828-39054829
25 SOS1 NM_005633.4(SOS1):c.1075-16C>T SNV Uncertain significance 932037 2:39251294-39251294 2:39024153-39024153
26 SOS1 NM_005633.3(SOS1):c.2489A>G (p.Asn830Ser) SNV Uncertain significance 181538 rs397517158 2:39237746-39237746 2:39010605-39010605
27 SOS1 NM_005633.3(SOS1):c.2165G>A (p.Arg722Lys) SNV Uncertain significance 477718 rs142666652 2:39240603-39240603 2:39013462-39013462
28 SOS1 NM_005633.3(SOS1):c.*3463A>G SNV Uncertain significance 335974 rs886056006 2:39209502-39209502 2:38982361-38982361
29 SOS1 NM_005633.3(SOS1):c.*2218T>A SNV Uncertain significance 335983 rs886056009 2:39210747-39210747 2:38983606-38983606
30 SOS1 NM_005633.3(SOS1):c.*298C>G SNV Uncertain significance 336012 rs886056021 2:39212667-39212667 2:38985526-38985526
31 SOS1 NM_005633.3(SOS1):c.*766del Deletion Uncertain significance 336004 rs533720751 2:39212199-39212199 2:38985058-38985058
32 SOS1 NM_005633.3(SOS1):c.*1385A>G SNV Uncertain significance 335995 rs868000333 2:39211580-39211580 2:38984439-38984439
33 SOS1 NM_005633.3(SOS1):c.*3416_*3417del Deletion Uncertain significance 335976 rs200892895 2:39209548-39209549 2:38982407-38982408
34 SOS1 NM_005633.3(SOS1):c.1659G>A (p.Met553Ile) SNV Uncertain significance 336020 rs886056025 2:39249910-39249910 2:39022769-39022769
35 SOS1 NM_005633.3(SOS1):c.*4023T>C SNV Uncertain significance 335966 rs1043800 2:39208942-39208942 2:38981801-38981801
36 SOS1 NM_005633.3(SOS1):c.3624T>C (p.Pro1208=) SNV Uncertain significance 336016 rs763107563 2:39213343-39213343 2:38986202-38986202
37 SOS1 NM_005633.3(SOS1):c.*534C>T SNV Uncertain significance 336009 rs773935049 2:39212431-39212431 2:38985290-38985290
38 SOS1 NM_005633.3(SOS1):c.*642T>C SNV Uncertain significance 336007 rs886056019 2:39212323-39212323 2:38985182-38985182
39 SOS1 NM_005633.3(SOS1):c.*2063_*2066dup Duplication Uncertain significance 335985 rs886056011 2:39210898-39210899 2:38983757-38983758
40 SOS1 NM_005633.3(SOS1):c.*2497G>A SNV Uncertain significance 335981 rs886056008 2:39210468-39210468 2:38983327-38983327
41 SOS1 NM_005633.3(SOS1):c.*3566_*3568del Deletion Uncertain significance 335972 rs886056005 2:39209397-39209399 2:38982256-38982258
42 SOS1 NM_005633.3(SOS1):c.*855G>A SNV Uncertain significance 336002 rs886056017 2:39212110-39212110 2:38984969-38984969
43 SOS1 NM_005633.3(SOS1):c.*1589T>G SNV Uncertain significance 335992 rs886056014 2:39211376-39211376 2:38984235-38984235
44 SOS1 NM_005633.3(SOS1):c.*3725T>C SNV Uncertain significance 335969 rs72799430 2:39209240-39209240 2:38982099-38982099
45 SOS1 NM_005633.3(SOS1):c.*1678C>A SNV Uncertain significance 335991 rs886056013 2:39211287-39211287 2:38984146-38984146
46 SOS1 NM_005633.3(SOS1):c.1720G>A (p.Val574Ile) SNV Uncertain significance 179117 rs727504641 2:39249849-39249849 2:39022708-39022708
47 SOS1 NM_005633.3(SOS1):c.*4110C>A SNV Uncertain significance 335965 rs886056003 2:39208855-39208855 2:38981714-38981714
48 SOS1 NM_005633.3(SOS1):c.*2048_*2050dup Duplication Uncertain significance 335986 rs761591990 2:39210914-39210915 2:38983773-38983774
49 SOS1 NM_005633.3(SOS1):c.3793T>G (p.Ser1265Ala) SNV Uncertain significance 336014 rs886056023 2:39213174-39213174 2:38986033-38986033
50 SOS1 NM_005633.3(SOS1):c.*2208dup Duplication Uncertain significance 335984 rs886056010 2:39210756-39210757 2:38983615-38983616

Expression for Gingival Fibromatosis

Search GEO for disease gene expression data for Gingival Fibromatosis.

Pathways for Gingival Fibromatosis

Pathways related to Gingival Fibromatosis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.59 TIMP2 TIMP1 TGFB1 SOS1 MMP3 MMP2
2
Show member pathways
13.33 TGFB1 SOS1 MMP3 MMP2 MMP1 ITGA2
3
Show member pathways
13.28 TIMP1 TGFB1 SOS1 MMP3 MMP2 MMP1
4
Show member pathways
12.93 TIMP2 TIMP1 TGFB1 SOS1 ITGA2 FN1
5 12.76 TGFB1 SOS1 MMP2 MMP1 ITGA2 FN1
6
Show member pathways
12.32 TIMP2 TIMP1 TGFB1 SOS1 ITGA2 CCN2
7
Show member pathways
12.26 TIMP2 TIMP1 TGFB1 SERPINH1 MMP3 MMP2
8 12.22 TGFB1 SOS1 MMP2 ITGA2 FN1
9
Show member pathways
12.21 TIMP1 SOS1 MMP3 MMP1 FN1
10
Show member pathways
12.16 TGFB1 SOS1 MMP1 FN1
11 12.11 TGFB1 SOS1 MMP2 MMP1
12 11.93 TGFB1 SOS1 MMP1 ITGA2 FN1
13 11.81 TGFB1 MMP2 FN1
14 11.78 TGFB1 MMP3 MMP1
15
Show member pathways
11.72 TIMP2 TIMP1 MMP3 MMP2 MMP1
16 11.69 TIMP1 TGFB1 MMP3 MMP2 MMP1 FN1
17 11.62 TIMP2 TIMP1 TGFB1 SOS1 ITGA2 CCN2
18 11.61 TGFB1 SERPINH1 CDKN1C
19 11.6 TIMP2 TIMP1 TGFB1 MMP3 MMP2
20
Show member pathways
11.59 MMP3 MMP2 MMP1
21 11.58 TIMP1 TGFB1 MMP2 CCN2
22 11.49 TGFB1 SOS1 CCN2
23 11.48 TGFB1 SOS1 MMP1
24 11.44 MMP2 FN1 CCN2
25 11.34 TIMP2 MMP3 MMP1
26 11.19 TGFB1 MMP2 ITGA2 FN1
27 11.07 SOS1 ITGA2 FN1
28 10.95 TIMP2 TIMP1 TGFB1 ITGA2 FN1 CCN2
29 10.91 TGFB1 FN1
30 10.89 TIMP2 TIMP1 MMP3 MMP2 MMP1 FN1
31 10.88 TGFB1 MMP1

GO Terms for Gingival Fibromatosis

Cellular components related to Gingival Fibromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 TIMP2 TIMP1 TGFB1 SERPINH1 MMP3 MMP2
2 platelet alpha granule lumen GO:0031093 9.43 TIMP1 TGFB1 FN1
3 collagen-containing extracellular matrix GO:0062023 9.43 TIMP2 TGFB1 SERPINH1 MMP2 FN1 CCN2
4 extracellular matrix GO:0031012 9.23 TIMP2 TIMP1 TGFB1 MMP3 MMP2 MMP1

Biological processes related to Gingival Fibromatosis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.88 TIMP1 MMP2 MMP1 FN1
2 leukocyte migration GO:0050900 9.85 TGFB1 SOS1 MMP1 FN1
3 aging GO:0007568 9.84 TIMP2 TIMP1 TGFB1 CCN2
4 response to hypoxia GO:0001666 9.8 TGFB1 REST MMP2 ITGA2
5 integrin-mediated signaling pathway GO:0007229 9.79 ITGA2 FN1 CCN2
6 cell-matrix adhesion GO:0007160 9.79 ITGA2 FN1 CCN2
7 response to organic substance GO:0010033 9.78 TIMP2 TIMP1 TGFB1
8 extracellular matrix organization GO:0030198 9.77 MMP3 MMP2 MMP1 ITGA2 FN1
9 response to wounding GO:0009611 9.76 TGFB1 FN1 CCN2
10 positive regulation of protein complex assembly GO:0031334 9.7 TGFB1 MMP3 MMP1
11 cytokine-mediated signaling pathway GO:0019221 9.7 TIMP1 TGFB1 SOS1 MMP3 MMP2 MMP1
12 response to amyloid-beta GO:1904645 9.62 MMP3 MMP2
13 collagen catabolic process GO:0030574 9.61 MMP3 MMP2 MMP1
14 cell activation GO:0001775 9.6 TIMP1 TGFB1
15 positive regulation of cardiac muscle contraction GO:0060452 9.59 KCNQ1 CCN2
16 negative regulation of mitotic cell cycle GO:0045930 9.58 TIMP2 TGFB1 CDKN1C
17 negative regulation of metallopeptidase activity GO:1905049 9.57 TIMP2 TIMP1
18 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.56 TIMP2 TIMP1
19 wound healing GO:0042060 9.56 TIMP1 TGFB1 ITGA2 FN1
20 regulation of T cell differentiation in thymus GO:0033081 9.51 SOS1 CAMK4
21 positive regulation of collagen biosynthetic process GO:0032967 9.5 TGFB1 ITGA2 CCN2
22 connective tissue development GO:0061448 9.48 TGFB1 CCN2
23 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.46 TIMP1 TGFB1
24 extracellular matrix disassembly GO:0022617 9.35 TIMP2 TIMP1 MMP3 MMP2 MMP1
25 cellular response to UV-A GO:0071492 8.92 TIMP1 MMP3 MMP2 MMP1

Molecular functions related to Gingival Fibromatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 9.5 MMP3 MMP2 MMP1
2 protease binding GO:0002020 9.43 TIMP2 TIMP1 FN1
3 metalloendopeptidase inhibitor activity GO:0008191 9.37 TIMP2 TIMP1
4 endopeptidase activity GO:0004175 9.33 MMP3 MMP2 MMP1
5 collagen binding GO:0005518 9.13 SERPINH1 ITGA2 FN1
6 integrin binding GO:0005178 8.92 TIMP2 ITGA2 FN1 CCN2

Sources for Gingival Fibromatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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