MCID: GNG006
MIFTS: 36

Gingival Hypertrophy

Categories: Oral diseases

Aliases & Classifications for Gingival Hypertrophy

MalaCards integrated aliases for Gingival Hypertrophy:

Name: Gingival Hypertrophy 12 6 44 15 70
Hypertrophy of Gingivae 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5338
MeSH 44 D005886
SNOMED-CT 67 54711002
UMLS 70 C0017567

Summaries for Gingival Hypertrophy

MalaCards based summary : Gingival Hypertrophy, also known as hypertrophy of gingivae, is related to fibromatosis and gingival overgrowth. An important gene associated with Gingival Hypertrophy is KCNK4 (Potassium Two Pore Domain Channel Subfamily K Member 4), and among its related pathways/superpathways are Interleukin-4 and 13 signaling and Matrix Metalloproteinases. The drugs Fibrin Tissue Adhesive and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include myeloid, skin and kidney, and related phenotypes are cellular and hematopoietic system

Related Diseases for Gingival Hypertrophy

Diseases related to Gingival Hypertrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 fibromatosis 30.7 VIM SOS1 ANTXR2
2 gingival overgrowth 30.5 SOS1 RET MMP3 KCNK4-TEX40 KCNK4
3 gingival fibromatosis 30.2 TIMP2 SOS1 MMP3
4 mucopolysaccharidosis-plus syndrome 30.0 IDUA GNPTAB GLB1
5 mucolipidosis 29.9 SERPINA3 IDUA GNPTAB GLB1
6 sphingolipidosis 29.9 SERPINA3 IDUA GLB1
7 tetralogy of fallot 29.8 SOS1 RET MMP9 MMP3
8 autosomal recessive disease 29.7 SERPINA3 IDUA GNPTAB ANTXR1
9 hyaline fibromatosis syndrome 11.4
10 rutherfurd syndrome 11.4
11 zimmermann-laband syndrome 1 11.1
12 mucolipidosis ii alpha/beta 11.1
13 frank-ter haar syndrome 11.1
14 lathosterolosis 11.1
15 macs syndrome 11.1
16 robinow syndrome, autosomal dominant 2 11.1
17 hennekam syndrome 11.1
18 gm1 gangliosidosis 11.1
19 prolapse of lacrimal gland 10.4 MMP9 MMP3
20 rheumatoid nodulosis 10.4 MMP9 MMP3
21 spastic entropion 10.4 MMP9 MMP3
22 tendinopathy 10.4 TIMP2 MMP3
23 intravascular papillary endothelial hyperplasia 10.4 VIM SERPINA3
24 oropharyngeal anthrax 10.4 ANTXR2 ANTXR1
25 facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome 10.4 KCNK4-TEX40 KCNK4
26 fungal keratitis 10.4 TIMP2 MMP9
27 congenital epulis 10.4 VIM SERPINA3
28 epulis 10.4 VIM SERPINA3
29 gastrointestinal anthrax 10.4 ANTXR2 ANTXR1
30 multicentric reticulohistiocytosis 10.4 VIM SERPINA3
31 ovarian mucinous cystadenocarcinoma 10.3 VIM SERPINA3
32 conjunctivochalasis 10.3 TIMP2 MMP9 MMP3
33 cutaneous anthrax 10.3 ANTXR2 ANTXR1
34 syringocystadenoma papilliferum 10.3 VIM SERPINA3
35 preterm premature rupture of the membranes 10.3 TIMP2 MMP9 MMP3
36 chondroid chordoma 10.3 VIM SERPINA3
37 odontogenic myxoma 10.3 VIM SERPINA3 MMP9
38 pneumothorax 10.3 VIM TIMP2 MMP9
39 inhalation anthrax 10.3 ANTXR2 ANTXR1
40 villonodular synovitis 10.3 SOS1 MMP9
41 benign giant cell tumor 10.3 VIM SERPINA3 MMP9
42 coronary aneurysm 10.3 MMP9 MMP3
43 varicose veins 10.3 TIMP2 MMP9 MMP3
44 pulmonary emphysema 10.3 TIMP2 SERPINA3 MMP9
45 lymph node disease 10.3 SERPINA3 RET MMP3
46 embryonal sarcoma 10.3 VIM SERPINA3
47 perforated corneal ulcer 10.3 MMP9 MMP3
48 synovitis 10.3 TIMP2 MMP9 MMP3
49 nodular tenosynovitis 10.3 VIM SERPINA3
50 heart aneurysm 10.3 MMP9 MMP3

Graphical network of the top 20 diseases related to Gingival Hypertrophy:



Diseases related to Gingival Hypertrophy

Symptoms & Phenotypes for Gingival Hypertrophy

MGI Mouse Phenotypes related to Gingival Hypertrophy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.11 ANTXR1 ANTXR2 CIB4 CLP1 GLB1 GNPTAB
2 hematopoietic system MP:0005397 10.1 ANTXR2 CLP1 GLB1 GNPTAB IDUA MMP3
3 homeostasis/metabolism MP:0005376 10.07 AGBL5 ANTXR2 GLB1 GNPTAB IDUA MMP3
4 immune system MP:0005387 9.97 AGBL5 ANTXR1 ANTXR2 CLP1 GLB1 GNPTAB
5 nervous system MP:0003631 9.7 CLP1 GLB1 GNPTAB IDUA KCNK4 MMP3
6 reproductive system MP:0005389 9.28 ANTXR1 ANTXR2 CIB4 GLB1 GNPTAB IDUA

Drugs & Therapeutics for Gingival Hypertrophy

Drugs for Gingival Hypertrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrin Tissue Adhesive
2 Mitogens

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Clinical Application of Diode Laser in Gingival Enlargement Related to Orthodontics Unknown status NCT01286298
2 The Determination of the Operative Temperature Levels Using Er:YAG Laser and Diode Laser Supported Resective Gingival Surgery and the Clinical and Biochemical Evaluation of it's Effect on Postoperative Imflammation, Epithelization and Pain Completed NCT04304391
3 Evaluation of the Effects of PRF, CGF and AFG Application on Wound Healing Following Gingivectomy and Gingivoplasty Operations: a Randomized Controlled Clinical Trial Completed NCT04805463
4 Development and Validation of the Periodontal Aesthetic Perception Scale in Patients With Periodontal Problems Completed NCT03436537
5 Evaluation of Temperature and Healing in Treatment of Gingival Enlargement Using Different Gingivectomy Techniques Completed NCT04016064
6 European Alpha-Mannosidosis Participant: An International, Multicenter, Epidemiological Protocol Recruiting NCT03651245

Search NIH Clinical Center for Gingival Hypertrophy

Cochrane evidence based reviews: gingival hypertrophy

Genetic Tests for Gingival Hypertrophy

Anatomical Context for Gingival Hypertrophy

MalaCards organs/tissues related to Gingival Hypertrophy:

40
Myeloid, Skin, Kidney, Breast, Bone, Heart, Endothelial

Publications for Gingival Hypertrophy

Articles related to Gingival Hypertrophy:

(show top 50) (show all 260)
# Title Authors PMID Year
1
Scurvy: A Disease not to be Forgotten. 61
33368529 2020
2
Neurocysticercosis: An Easy to Miss Diagnosis in Non-Endemic Regions. 61
33329988 2020
3
Juvenile Hyaline Fibromatosis: Literature Review and a Case Treated With Surgical Excision and Corticosteroid. 61
33173631 2020
4
Autoimmune Hepatitis in Children: Prednisone Plus Azathioprine Versus Cyclosporine: A Randomized Trial. 61
32520828 2020
5
Amlodipine-induced gingival hypertrophy. 61
32616341 2020
6
Assessment of oro-dental manifestations in a series of acromegalic patients, the AcroDent study. 61
32738132 2020
7
Dilated cardiomyopathy in mucolipidosis type 2. 61
33000604 2020
8
Gingival Hypertrophy in a Child with Hyaline Fibromatosis Syndrome. 61
32523159 2020
9
Anesthetic Management of an Adult Patient With Hyaline Fibromatosis Syndrome Undergoing Laparoscopic Colectomy: A Case Report. 61
31842195 2020
10
[Erythrophagocytosis by blast cells and de novo T cell LAL without cytogenetic abnormalities in a Moroccan patient]. 61
32963668 2020
11
Juvenile Hyaline Fibromatosis Management With a Diode Laser: A Rare Case Report. 61
32099635 2020
12
Zimmermann-Laband-1 Syndrome: Clinical, Histological, and Proteomic Findings of a 3-Year-Old Patient with Hereditary Gingival Fibromatosis. 61
31261938 2019
13
Juvenile hyaline fibromatosis in siblings. 61
30971561 2019
14
Cyclosporine-Induced Gingival Hypertrophy. 61
30516804 2019
15
Oral Manifestations of Autoimmune Neutropenia: A Case Report. 61
30289370 2019
16
Unilateral eyelid edema and mucosal involvement as the first presentations of Wegener granulomatosis. 61
31558999 2019
17
Hyaline fibromatosis syndrome: Clinical update and phenotype-genotype correlations. 61
30176098 2018
18
Safety and Effectiveness of Conversion From Cyclosporine to Once-Daily Prolonged-Release Tacrolimus in Stable Kidney Transplant Patients: A Multicenter Observational Study in Japan. 61
30577196 2018
19
Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review. 61
30091458 2018
20
Medical Complications Of Renal Transplant - 2 Years' Experience At Armed Forces Institute Of Urology. 61
30465363 2018
21
Mucopolysaccharidosis VI and effects on growth of the apical bases: a case report. 61
29722897 2018
22
Surgical Management of Facial Features of Robinow Syndrome: A Case Report. 61
29610615 2018
23
Skin manifestations among GATA2-deficient patients. 61
28440875 2018
24
CYP2C9 polymorphisms in epilepsy: influence on phenytoin treatment. 61
29636628 2018
25
A case of Donohue syndrome "Leprechaunism" with a novel mutation in the insulin receptor gene. 61
29483803 2017
26
Image Gallery: Juvenile autoimmune pemphigus presenting with diffuse gingival hypertrophy and antibodies against desmocollin 3. 61
29192983 2017
27
Cytology and molecular mechanisms of drug-induced gingival hypertrophy: a rewiew. 61
29285323 2017
28
CMG2/ANTXR2 regulates extracellular collagen VI which accumulates in hyaline fibromatosis syndrome. 61
28604699 2017
29
Infantile Systemic Hyalinosis Complicated with Right Atrial Thrombus and Pericardial Effusion in an Infant. 61
25458638 2017
30
Infantile Systemic Hyalinosis: Novel Founder Mutation in the Initiation Codon among "Malis (Farmers)" in Jodhpur. 61
27753005 2016
31
The role of exclusive enteral nutrition in the management of orofacial granulomatosis in children. 61
27457793 2016
32
Extramedullary Disease in Adult Acute Myeloid Leukemia Is Common but Lacks Independent Significance: Analysis of Patients in ECOG-ACRIN Cancer Research Group Trials, 1980-2008. 61
27573652 2016
33
Mannose 6-phosphate-dependent targeting of lysosomal enzymes is required for normal craniofacial and dental development. 61
27239697 2016
34
Infantile systemic hyalinosis: Report of two severe cases from Saudi Arabia and review of the literature. 61
27195198 2016
35
MRI and MRS findings in fucosidosis; a rare lysosomal storage disease. 61
26515723 2016
36
Gingival hypertrophy in a child: Expect the unexpected. 61
27433057 2016
37
[Malignant infantile osteopetrosis: Case report of a 5-month-old boy]. 61
26850155 2016
38
Comment on "Treatment of Massive Labial and Gingival Hypertrophy in a Patient With Infantile Systemic Hyalinosis--A Case Report". 61
26687153 2016
39
[Neonatal mucolipidosis type II]. 61
26552632 2016
40
Identical Twins with Infantile Systemic Hyalinosis: Case study and review of literature. 61
27299133 2016
41
Unusual cause for gum hypertrophy and skin nodules in a child. 61
26682835 2015
42
Treatment of Massive Labial and Gingival Hypertrophy in a Patient With Infantile Systemic Hyalinosis-A Case Report. 61
26207694 2015
43
[Hyaline fibromatosis syndrome: case report of two siblings]. 61
26294158 2015
44
Missing diagnosis: gingival hypertrophy due to amlodipine. 61
26432745 2015
45
Haemorrhagic Gingival Hypertrophy: A Striking Presentation of Acute Myelomonocytic Leukaemia. 61
26667875 2015
46
Diagnosis of acute myeloid leukemia in a dental hospital; report of a case with severe gingival hypertrophy. 61
25966736 2015
47
Tumor-induced rickets in a child with a central giant cell granuloma: a case report. 61
26009620 2015
48
Amlodipine-induced Gingival Hyperplasia - A Case Report and Review. 61
26426184 2015
49
Clinical Findings and Natural History in Ten Unrelated Families with Juvenile and Adult GM1 Gangliosidosis. 61
26108645 2015
50
Hyaline fibromatosis syndrome with mutation c.1074delT of the CMG2 gene: a case report. 61
25186005 2014

Variations for Gingival Hypertrophy

ClinVar genetic disease variations for Gingival Hypertrophy:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 KCNK4-TEX40 , KCNK4 NM_033310.3(KCNK4):c.515C>A (p.Ala172Glu) SNV Pathogenic 560221 rs1565369746 GRCh37: 11:64064979-64064979
GRCh38: 11:64297507-64297507
2 KCNK4-TEX40 , KCNK4 NM_033310.3(KCNK4):c.730G>C (p.Ala244Pro) SNV Pathogenic 560222 rs1189909394 GRCh37: 11:64065650-64065650
GRCh38: 11:64298178-64298178
3 RET NM_020975.6(RET):c.2753T>C (p.Met918Thr) SNV Pathogenic 13919 rs74799832 GRCh37: 10:43617416-43617416
GRCh38: 10:43121968-43121968

Expression for Gingival Hypertrophy

Search GEO for disease gene expression data for Gingival Hypertrophy.

Pathways for Gingival Hypertrophy

Pathways related to Gingival Hypertrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.55 VIM MMP9 MMP3
2
Show member pathways
11.43 TIMP2 MMP9 MMP3
3 11.28 TIMP2 MMP9 MMP3
4 10.92 TIMP2 MMP9 MMP3
5
Show member pathways
10.67 IDUA GLB1
6 10.39 TIMP2 MMP9 MMP3

GO Terms for Gingival Hypertrophy

Biological processes related to Gingival Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.62 VIM SOS1 MMP9 MMP3
2 response to amyloid-beta GO:1904645 9.26 MMP9 MMP3
3 regulation of neuroinflammatory response GO:0150077 9.16 MMP9 MMP3
4 cellular response to UV-A GO:0071492 8.96 MMP9 MMP3
5 extracellular matrix disassembly GO:0022617 8.8 TIMP2 MMP9 MMP3

Sources for Gingival Hypertrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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