MCID: GNG006
MIFTS: 34

Gingival Hypertrophy

Categories: Oral diseases

Aliases & Classifications for Gingival Hypertrophy

MalaCards integrated aliases for Gingival Hypertrophy:

Name: Gingival Hypertrophy 12 44 15 73
Hypertrophy of Gingivae 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5338
MeSH 44 D005886
SNOMED-CT 68 54711002
UMLS 73 C0017567

Summaries for Gingival Hypertrophy

MalaCards based summary : Gingival Hypertrophy, also known as hypertrophy of gingivae, is related to lipoid proteinosis of urbach and wiethe and fibromatosis. An important gene associated with Gingival Hypertrophy is ANTXR2 (ANTXR Cell Adhesion Molecule 2), and among its related pathways/superpathways are Degradation of the extracellular matrix and Microglia Activation During Neuroinflammation: Overview. The drugs Tacrolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include bone, myeloid and monocytes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Gingival Hypertrophy

Diseases related to Gingival Hypertrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 lipoid proteinosis of urbach and wiethe 29.9 ANTXR2 MMP9
2 fibromatosis 29.8 ANTXR2 VIM
3 rutherfurd syndrome 11.5
4 hyaline fibromatosis syndrome 11.3
5 zimmermann-laband syndrome 1 11.1
6 frank-ter haar syndrome 11.1
7 lathosterolosis 11.1
8 robinow syndrome, autosomal dominant 2 11.1
9 gingival overgrowth 11.1
10 leukemia 10.1
11 fungal keratitis 10.1 MMP9 TIMP2
12 nasal cavity squamous cell carcinoma 10.1 MMP9 TIMP2
13 villonodular synovitis 10.0 MMP9 VIM
14 preterm premature rupture of the membranes 10.0 MMP9 TIMP2
15 adenomyosis 10.0 MMP9 TIMP2
16 pulmonary emphysema 10.0 MMP9 TIMP2
17 odontogenic myxoma 10.0 MMP9 VIM
18 inguinal hernia 10.0 MMP9 TIMP2
19 rheumatoid nodulosis 10.0 MMP3 MMP9
20 spastic entropion 10.0 MMP3 MMP9
21 blepharochalasis 10.0 MMP3 MMP9
22 adult astrocytic tumour 9.9 MMP3 MMP9
23 giant cell tumor 9.9 MMP9 VIM
24 corneal ulcer 9.9 MMP3 MMP9
25 gliosarcoma 9.9 MMP9 VIM
26 arteriovenous malformation 9.9 MMP3 MMP9
27 conjunctivochalasis 9.9 MMP3 TIMP2
28 sorsby fundus dystrophy 9.9 MMP3 TIMP2
29 spinal stenosis 9.9 MMP3 TIMP2
30 carotid artery disease 9.9 MMP3 MMP9
31 takayasu arteritis 9.9 MMP3 MMP9
32 microvascular complications of diabetes 1 9.9 MMP9 TIMP2
33 periodontitis 9.8 MMP3 MMP9
34 thrombocytopenic purpura, autoimmune 9.8
35 myofibromatosis, infantile, 1 9.8
36 mowat-wilson syndrome 9.8
37 leukemia, acute myeloid 9.8
38 muscle hypertrophy 9.8
39 megakaryocytic leukemia 9.8
40 osteopetrosis 9.8
41 microcephaly 9.8
42 purpura 9.8
43 myeloid leukemia 9.8
44 pemphigus 9.8
45 kawasaki disease 9.8 MMP3 MMP9
46 varicose veins 9.8 MMP3 MMP9 TIMP2
47 aortic aneurysm, familial abdominal, 1 9.8 MMP3 MMP9 TIMP2
48 periodontal disease 9.8 MMP3 MMP9 TIMP2
49 fundus dystrophy 9.8 MMP3 MMP9 TIMP2
50 fibrosarcoma 9.5 MMP3 MMP9 TIMP2 VIM

Graphical network of the top 20 diseases related to Gingival Hypertrophy:



Diseases related to Gingival Hypertrophy

Symptoms & Phenotypes for Gingival Hypertrophy

GenomeRNAi Phenotypes related to Gingival Hypertrophy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.36 RIN2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.36 ANTXR2 RIN2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.36 ANTXR2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.36 ANTXR2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.36 ANTXR2 RIN2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.36 RIN2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.36 ANTXR2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.36 ANTXR2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.36 ANTXR2
10 Decreased cell migration GR00055-A-1 9.13 MMP3 TIMP2 VIM

MGI Mouse Phenotypes related to Gingival Hypertrophy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.02 ANTXR2 MMP3 MMP9 TIMP2 VIM

Drugs & Therapeutics for Gingival Hypertrophy

Drugs for Gingival Hypertrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
4 Antioxidants Phase 4
5 Anthocyanidin Phase 4
6 Anti-Infective Agents Phase 4,Not Applicable
7
Procyanidin Phase 4 4852-22-6 147299
8 Vitamins Phase 4,Early Phase 1
9 Antiparasitic Agents Phase 4
10 Proanthocyanidin Phase 4
11 Antiprotozoal Agents Phase 4
12 Protective Agents Phase 4
13 Dermatologic Agents Phase 4,Not Applicable
14 Calcineurin Inhibitors Phase 4
15 Antirheumatic Agents Phase 4
16 Cyclosporins Phase 4
17 Antifungal Agents Phase 4
18 Immunologic Factors Phase 4
19 Immunosuppressive Agents Phase 4
20
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
21
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
22
Racepinephrine Approved Not Applicable 329-65-7 838
23
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 2713 9552079
24
Ergocalciferol Approved, Nutraceutical Early Phase 1 50-14-6 5280793
25
Vitamin D Approved, Nutraceutical, Vet_approved Early Phase 1 1406-16-2
26
Vitamin D3 Approved, Nutraceutical Early Phase 1 67-97-0 5280795 6221
27
Pomegranate Experimental, Investigational Not Applicable
28 Anesthetics Not Applicable
29 Anesthetics, Local Not Applicable
30 Chlorhexidine gluconate Not Applicable
31 Trichostatin A Not Applicable
32 Epinephryl borate Not Applicable
33 Disinfectants Not Applicable
34 Sweet Basil Not Applicable
35 Anti-Bacterial Agents Not Applicable
36 Anti-Inflammatory Agents Not Applicable,Early Phase 1
37 Anti-Infective Agents, Local Not Applicable,Early Phase 1
38 Holy Basil Not Applicable
39 Trace Elements Early Phase 1
40 Bone Density Conservation Agents Early Phase 1
41 Calciferol Early Phase 1
42 Ergocalciferols Early Phase 1
43 Vitamin D2 Early Phase 1
44 Micronutrients Early Phase 1

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs Completed NCT02515929 Phase 4
2 A Study to Assess the Safety and Efficacy of a Tacrolimus Based Immunosuppressive Regimen in Stable Kidney Transplant Recipients Converted From Cyclosporine Based Immunosuppressive Regimen Terminated NCT02963103 Phase 4 Tacrolimus
3 Diode Laser in Gingival Enlargement Related to Orthodontics Unknown status NCT01286298 Not Applicable
4 Development and Validation of the Periodontal Aesthetic Perception Scale in Patients With Periodontal Problems Completed NCT03436537
5 Scalpel Versus Laser Gingivectomy in Orthodontic Patients in the Management of Periodontal Health Completed NCT03514316 Not Applicable
6 Comparative Evaluation of Antiplaque and Antigingivitis Efficacy of Ocimum Sanctum (Tulsi) Extract Completed NCT03474146 Not Applicable
7 Dose-dependent Anti-inflammatory Effects of Vitamin D in a Human Gingivitis Model Completed NCT00779909 Early Phase 1 vitamin D3
8 Iranian Traditional Mouth Rinse Punica Granatum Pleniflora (Golnaar) in Treatment of Gingivitis in Diabetic Patients Completed NCT02227485 Not Applicable Punica granatum Pleniflora (Golnaar) mouth rinse;Chlorhexidine (0.2%)
9 European Alpha-Mannosidosis Patient Epidemiological Program Recruiting NCT03651245
10 Evaluation of a Daily Oral Care Lozenge on Oral Health and Quality of Life in Older Adults Recruiting NCT03693027 Not Applicable
11 Buccodental Manifestations in Patients With Acromegaly Recruiting NCT03401008
12 PeriImplant Soft Tissue and Marginal Bone Loss of Single Implant Mandibular Overdenture Recruiting NCT02881905 Not Applicable
13 Standard Root Planing vs. Periodontal Structure Repair Device for Treatment of Pockets Caused by Periodontal Disease Not yet recruiting NCT03671512 Not Applicable

Search NIH Clinical Center for Gingival Hypertrophy

Cochrane evidence based reviews: gingival hypertrophy

Genetic Tests for Gingival Hypertrophy

Anatomical Context for Gingival Hypertrophy

MalaCards organs/tissues related to Gingival Hypertrophy:

41
Bone, Myeloid, Monocytes

Publications for Gingival Hypertrophy

Articles related to Gingival Hypertrophy:

(show all 36)
# Title Authors Year
1
Cyclosporine-Induced Gingival Hypertrophy. ( 30516804 )
2018
2
Image Gallery: Juvenile autoimmune pemphigus presenting with diffuse gingival hypertrophy and antibodies against desmocollin 3. ( 29192983 )
2017
3
Cytology and molecular mechanisms of drug-induced gingival hypertrophy: a rewiew. ( 29285323 )
2017
4
Gingival hypertrophy in a child: Expect the unexpected. ( 27433057 )
2016
5
Comment on &amp;quot;Treatment of Massive Labial and Gingival Hypertrophy in a Patient With Infantile Systemic Hyalinosis-A Case Report&amp;quot;. ( 26687153 )
2016
6
Diagnosis of acute myeloid leukemia in a dental hospital; report of a case with severe gingival hypertrophy. ( 25966736 )
2015
7
Haemorrhagic Gingival Hypertrophy: A Striking Presentation of Acute Myelomonocytic Leukaemia. ( 26667875 )
2015
8
Missing diagnosis: Gingival hypertrophy due to amlodipine. ( 26432745 )
2015
9
Treatment of Massive Labial and Gingival Hypertrophy in a Patient With Infantile Systemic Hyalinosis-A Case Report. ( 26207694 )
2015
10
A new finding in a patient with Mowat Wilson syndrome: peripupillary atrophy and gingival hypertrophy. ( 23610866 )
2013
11
Nifedipine-induced gingival hypertrophy. ( 22214637 )
2012
12
Amlodipine-induced massive gingival hypertrophy. ( 21490356 )
2011
13
Matrix metalloproteinase 9 levels in gingival crevicular fluid in patients after periodontal microsurgery for orthodontic induced gingival hypertrophy. ( 21424088 )
2011
14
Images in clinical medicine. Medication-induced gingival hypertrophy. ( 19129521 )
2009
15
Gingival hypertrophy and anemia. ( 19221270 )
2009
16
Gingival hypertrophy: a solitary manifestation of scurvy. ( 19144306 )
2008
17
Idiopathic gingival hypertrophy--a morphological study and a review of literature. ( 20209790 )
2008
18
A 3-month-old infant with gingival hypertrophy and hepatosplenomegaly. Osteopetrosis. ( 18616190 )
2008
19
Images in clinical medicine. Gingival hypertrophy and leukemia. ( 18923168 )
2008
20
Acute myeloblastic leukaemia (AML-M1) presenting with prominent gingival hypertrophy. ( 17331137 )
2007
21
Case records of the Massachusetts General Hospital. Case 23-2007. A 9-year-old boy with bone pain, rash, and gingival hypertrophy. ( 17652655 )
2007
22
The role of lipoid proteinosis in gingival hypertrophy. ( 15259977 )
2004
23
Gingival hypertrophy due to drugs. ( 11574994 )
2001
24
Syndrome of gingival hypertrophy, hirsutism, mental retardation and brachymetacarpia in two sisters: specific entity or variant of a described condition? ( 11102931 )
2000
25
Gingival hypertrophy in acute megakaryoblastic leukemia. ( 9361488 )
1997
26
Treatment of cyclosporine-induced gingival hypertrophy. ( 9054291 )
1997
27
Juvenile systemic hyalinosis--a rare cause of gingival hypertrophy: a case report. ( 8695589 )
1996
28
Resolution of cyclosporin-induced gingival hypertrophy with metronidazole. ( 7909047 )
1994
29
Images in clinical medicine. Gingival hypertrophy in myelomonocytic leukemia. ( 8114835 )
1994
30
A terminal deletion (14)(q31.1) in a child with microcephaly, narrow palate, gingival hypertrophy, protuberant ears, and mild mental retardation. ( 2918542 )
1989
31
Idiopathic thrombocytopenic purpura manifesting as gingival hypertrophy: case report. ( 1068274 )
1976
32
Congenital generalized fibromatosis. An African case with gingival hypertrophy and other unusual features. ( 1086595 )
1976
33
Gingival hypertrophy after diphenylhydantoin. ( 5078151 )
1972
34
A case of acute monocytic leukaemia with gingival hypertrophy. ( 5254309 )
1969
35
Fibromatous gingival hypertrophy. Report of two cases. ( 14009155 )
1962
36
Familial gingival hypertrophy in the dog (boxer breed). ( 14943353 )
1952

Variations for Gingival Hypertrophy

Expression for Gingival Hypertrophy

Search GEO for disease gene expression data for Gingival Hypertrophy.

Pathways for Gingival Hypertrophy

GO Terms for Gingival Hypertrophy

Cellular components related to Gingival Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ficolin-1-rich granule lumen GO:1904813 9.16 MMP9 TIMP2
2 tertiary granule lumen GO:1904724 8.96 MMP9 TIMP2
3 extracellular matrix GO:0031012 8.8 MMP3 MMP9 TIMP2

Biological processes related to Gingival Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.33 MMP3 MMP9 VIM
2 collagen catabolic process GO:0030574 9.26 MMP3 MMP9
3 regulation of neuroinflammatory response GO:0150077 8.96 MMP3 MMP9
4 extracellular matrix disassembly GO:0022617 8.8 MMP3 MMP9 TIMP2

Molecular functions related to Gingival Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 8.96 MMP3 MMP9
2 endopeptidase activity GO:0004175 8.62 MMP3 MMP9

Sources for Gingival Hypertrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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