MCID: GNG006
MIFTS: 36

Gingival Hypertrophy

Categories: Oral diseases

Aliases & Classifications for Gingival Hypertrophy

MalaCards integrated aliases for Gingival Hypertrophy:

Name: Gingival Hypertrophy 12 44 15 73
Hypertrophy of Gingivae 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5338
MeSH 44 D005886
SNOMED-CT 68 441787004 54711002
UMLS 73 C0017567

Summaries for Gingival Hypertrophy

MalaCards based summary : Gingival Hypertrophy, also known as hypertrophy of gingivae, is related to fibromatosis and periodontitis. An important gene associated with Gingival Hypertrophy is ANTXR2 (ANTXR Cell Adhesion Molecule 2), and among its related pathways/superpathways are Degradation of the extracellular matrix and Adhesion. The drugs Miconazole and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and monocytes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Gingival Hypertrophy

Diseases related to Gingival Hypertrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 fibromatosis 29.6 ANTXR2 VIM
2 periodontitis 28.7 MMP3 MMP9
3 rutherfurd syndrome 11.3
4 hyaline fibromatosis syndrome 11.2
5 zimmermann-laband syndrome 1 11.0
6 frank-ter haar syndrome 11.0
7 lathosterolosis 11.0
8 robinow syndrome, autosomal dominant 2 11.0
9 gingival overgrowth 11.0
10 gingivitis 10.5
11 rheumatoid nodulosis 10.2 MMP3 MMP9
12 spastic entropion 10.2 MMP3 MMP9
13 blepharochalasis 10.2 MMP3 MMP9
14 adult astrocytic tumour 10.2 MMP3 MMP9
15 corneal ulcer 10.1 MMP3 MMP9
16 pelvic organ prolapse 10.1 MMP3 MMP9
17 villonodular synovitis 10.1 MMP9 VIM
18 arteriovenous malformation 10.1 MMP3 MMP9
19 leukemia 10.0
20 odontogenic myxoma 10.0 MMP9 VIM
21 pneumothorax 9.9 MMP9 VIM
22 takayasu arteritis 9.9 MMP3 MMP9
23 giant cell tumor 9.8 MMP9 VIM
24 microcystic meningioma 9.8 MMP9 TIMP2
25 nasal cavity squamous cell carcinoma 9.8 MMP9 TIMP2
26 gliosarcoma 9.7 MMP9 VIM
27 conjunctivochalasis 9.7 MMP3 TIMP2
28 thrombocytopenic purpura, autoimmune 9.7
29 myofibromatosis, infantile, 1 9.7
30 mowat-wilson syndrome 9.7
31 lipoid proteinosis of urbach and wiethe 9.7
32 leukemia, acute myeloid 9.7
33 megakaryocytic leukemia 9.7
34 osteopetrosis 9.7
35 microcephaly 9.7
36 purpura 9.7
37 myeloid leukemia 9.7
38 pemphigus 9.7
39 kawasaki disease 9.7 MMP3 MMP9
40 pulmonary emphysema 9.7 MMP9 TIMP2
41 spinal stenosis 9.6 MMP3 TIMP2
42 inguinal hernia 9.6 MMP9 TIMP2
43 adenomyosis 9.3 MMP3 MMP9 TIMP2
44 sorsby fundus dystrophy 9.3 MMP3 MMP9 TIMP2
45 varicose veins 9.3 MMP3 MMP9 TIMP2
46 aortic aneurysm, familial abdominal, 1 9.2 MMP3 MMP9 TIMP2
47 periodontal disease 9.2 MMP3 MMP9 TIMP2
48 fundus dystrophy 9.2 MMP3 MMP9 TIMP2
49 ewing sarcoma 9.0 MMP3 MMP9 VIM
50 fibrosarcoma 8.5 MMP3 MMP9 TIMP2 VIM

Graphical network of the top 20 diseases related to Gingival Hypertrophy:



Diseases related to Gingival Hypertrophy

Symptoms & Phenotypes for Gingival Hypertrophy

GenomeRNAi Phenotypes related to Gingival Hypertrophy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.36 RIN2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.36 ANTXR2 RIN2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.36 ANTXR2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.36 ANTXR2
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.36 ANTXR2 RIN2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.36 RIN2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.36 ANTXR2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.36 ANTXR2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.36 ANTXR2
10 Decreased cell migration GR00055-A-1 9.13 MMP3 TIMP2 VIM

MGI Mouse Phenotypes related to Gingival Hypertrophy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.02 ANTXR2 MMP3 MMP9 TIMP2 VIM

Drugs & Therapeutics for Gingival Hypertrophy

Drugs for Gingival Hypertrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
2
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
3
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
4 Dermatologic Agents Phase 4,Not Applicable
5 Vitamins Phase 4,Early Phase 1
6 Anti-Infective Agents Phase 4,Not Applicable
7 Antioxidants Phase 4
8 Protective Agents Phase 4
9 Antiparasitic Agents Phase 4
10 Antiprotozoal Agents Phase 4
11 Cyclosporins Phase 4
12 Immunosuppressive Agents Phase 4
13 Antifungal Agents Phase 4
14 Antirheumatic Agents Phase 4
15 Calcineurin Inhibitors Phase 4
16
Procyanidin Nutraceutical Phase 4 4852-22-6 147299
17 Anthocyanidin Nutraceutical Phase 4
18 Proanthocyanidin Nutraceutical Phase 4
19
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 9552079 2713
20
Vitamin D Approved, Nutraceutical, Vet_approved Early Phase 1 1406-16-2
21
Vitamin D3 Approved, Nutraceutical Early Phase 1 67-97-0 6221 5280795
22
Ergocalciferol Approved, Nutraceutical Early Phase 1 50-14-6 5280793
23 Chlorhexidine gluconate Not Applicable
24 Micronutrients Early Phase 1
25 Trace Elements Early Phase 1
26 Disinfectants Not Applicable
27 Ergocalciferols Early Phase 1
28 Anti-Infective Agents, Local Early Phase 1,Not Applicable
29 Anti-Inflammatory Agents Early Phase 1
30 Bone Density Conservation Agents Early Phase 1
31 Vitamin D2 Nutraceutical Early Phase 1
32 Pomegranate Nutraceutical Not Applicable
33 Calciferol Nutraceutical Early Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs Completed NCT02515929 Phase 4
2 A Study to Assess the Safety and Efficacy of a Tacrolimus Based Immunosuppressive Regimen in Stable Kidney Transplant Recipients Converted From Cyclosporine Based Immunosuppressive Regimen Terminated NCT02963103 Phase 4 Tacrolimus
3 Diode Laser in Gingival Enlargement Related to Orthodontics Unknown status NCT01286298 Not Applicable
4 Development and Validation of the Periodontal Aesthetic Perception Scale in Patients With Periodontal Problems Completed NCT03436537
5 Scalpel Versus Laser Gingivectomy in Orthodontic Patients in the Management of Periodontal Health Completed NCT03514316 Not Applicable
6 Comparative Evaluation of Antiplaque and Antigingivitis Efficacy of Ocimum Sanctum (Tulsi) Extract Completed NCT03474146 Not Applicable
7 Dose-dependent Anti-inflammatory Effects of Vitamin D in a Human Gingivitis Model Completed NCT00779909 Early Phase 1 vitamin D3
8 Iranian Traditional Mouth Rinse Punica Granatum Pleniflora (Golnaar) in Treatment of Gingivitis in Diabetic Patients Completed NCT02227485 Not Applicable Punica granatum Pleniflora (Golnaar) mouth rinse;Chlorhexidine (0.2%)
9 BioHFS - Biomarker for Hyaline Fibromatosis Syndrome Recruiting NCT03196115
10 Buccodental Manifestations in Patients With Acromegaly Recruiting NCT03401008
11 PeriImplant Soft Tissue and Marginal Bone Loss of Single Implant Mandibular Overdenture Recruiting NCT02881905 Not Applicable

Search NIH Clinical Center for Gingival Hypertrophy

Cochrane evidence based reviews: gingival hypertrophy

Genetic Tests for Gingival Hypertrophy

Anatomical Context for Gingival Hypertrophy

MalaCards organs/tissues related to Gingival Hypertrophy:

41
Bone, Kidney, Monocytes, Myeloid

Publications for Gingival Hypertrophy

Articles related to Gingival Hypertrophy:

(show all 35)
# Title Authors Year
1
Image Gallery: Juvenile autoimmune pemphigus presenting with diffuse gingival hypertrophy and antibodies against desmocollin 3. ( 29192983 )
2017
2
Cytology and molecular mechanisms of drug-induced gingival hypertrophy: a rewiew. ( 29285323 )
2017
3
Gingival hypertrophy in a child: Expect the unexpected. ( 27433057 )
2016
4
Comment on &amp;quot;Treatment of Massive Labial and Gingival Hypertrophy in a Patient With Infantile Systemic Hyalinosis-A Case Report&amp;quot;. ( 26687153 )
2016
5
Diagnosis of acute myeloid leukemia in a dental hospital; report of a case with severe gingival hypertrophy. ( 25966736 )
2015
6
Haemorrhagic Gingival Hypertrophy: A Striking Presentation of Acute Myelomonocytic Leukaemia. ( 26667875 )
2015
7
Missing diagnosis: Gingival hypertrophy due to amlodipine. ( 26432745 )
2015
8
Treatment of Massive Labial and Gingival Hypertrophy in a Patient With Infantile Systemic Hyalinosis-A Case Report. ( 26207694 )
2015
9
A new finding in a patient with Mowat Wilson syndrome: peripupillary atrophy and gingival hypertrophy. ( 23610866 )
2013
10
Nifedipine-induced gingival hypertrophy. ( 22214637 )
2012
11
Amlodipine-induced massive gingival hypertrophy. ( 21490356 )
2011
12
Matrix metalloproteinase 9 levels in gingival crevicular fluid in patients after periodontal microsurgery for orthodontic induced gingival hypertrophy. ( 21424088 )
2011
13
Images in clinical medicine. Medication-induced gingival hypertrophy. ( 19129521 )
2009
14
Gingival hypertrophy and anemia. ( 19221270 )
2009
15
Gingival hypertrophy: a solitary manifestation of scurvy. ( 19144306 )
2008
16
Idiopathic gingival hypertrophy--a morphological study and a review of literature. ( 20209790 )
2008
17
A 3-month-old infant with gingival hypertrophy and hepatosplenomegaly. Osteopetrosis. ( 18616190 )
2008
18
Images in clinical medicine. Gingival hypertrophy and leukemia. ( 18923168 )
2008
19
Acute myeloblastic leukaemia (AML-M1) presenting with prominent gingival hypertrophy. ( 17331137 )
2007
20
Case records of the Massachusetts General Hospital. Case 23-2007. A 9-year-old boy with bone pain, rash, and gingival hypertrophy. ( 17652655 )
2007
21
The role of lipoid proteinosis in gingival hypertrophy. ( 15259977 )
2004
22
Gingival hypertrophy due to drugs. ( 11574994 )
2001
23
Syndrome of gingival hypertrophy, hirsutism, mental retardation and brachymetacarpia in two sisters: specific entity or variant of a described condition? ( 11102931 )
2000
24
Gingival hypertrophy in acute megakaryoblastic leukemia. ( 9361488 )
1997
25
Treatment of cyclosporine-induced gingival hypertrophy. ( 9054291 )
1997
26
Juvenile systemic hyalinosis--a rare cause of gingival hypertrophy: a case report. ( 8695589 )
1996
27
Resolution of cyclosporin-induced gingival hypertrophy with metronidazole. ( 7909047 )
1994
28
Images in clinical medicine. Gingival hypertrophy in myelomonocytic leukemia. ( 8114835 )
1994
29
A terminal deletion (14)(q31.1) in a child with microcephaly, narrow palate, gingival hypertrophy, protuberant ears, and mild mental retardation. ( 2918542 )
1989
30
Idiopathic thrombocytopenic purpura manifesting as gingival hypertrophy: case report. ( 1068274 )
1976
31
Congenital generalized fibromatosis. An African case with gingival hypertrophy and other unusual features. ( 1086595 )
1976
32
Gingival hypertrophy after diphenylhydantoin. ( 5078151 )
1972
33
A case of acute monocytic leukaemia with gingival hypertrophy. ( 5254309 )
1969
34
Fibromatous gingival hypertrophy. Report of two cases. ( 14009155 )
1962
35
Familial gingival hypertrophy in the dog (boxer breed). ( 14943353 )
1952

Variations for Gingival Hypertrophy

Expression for Gingival Hypertrophy

Search GEO for disease gene expression data for Gingival Hypertrophy.

Pathways for Gingival Hypertrophy

GO Terms for Gingival Hypertrophy

Cellular components related to Gingival Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ficolin-1-rich granule lumen GO:1904813 9.16 MMP9 TIMP2
2 tertiary granule lumen GO:1904724 8.96 MMP9 TIMP2
3 extracellular matrix GO:0031012 8.8 MMP3 MMP9 TIMP2

Biological processes related to Gingival Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen catabolic process GO:0030574 9.16 MMP3 MMP9
2 cytokine-mediated signaling pathway GO:0019221 9.13 MMP3 MMP9 VIM
3 extracellular matrix disassembly GO:0022617 8.8 MMP3 MMP9 TIMP2

Molecular functions related to Gingival Hypertrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metalloendopeptidase activity GO:0004222 8.96 MMP3 MMP9
2 endopeptidase activity GO:0004175 8.62 MMP3 MMP9

Sources for Gingival Hypertrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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