MCID: GNG012
MIFTS: 51

Gingival Overgrowth

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Gingival Overgrowth

MalaCards integrated aliases for Gingival Overgrowth:

Name: Gingival Overgrowth 12 29 54 6 43 15
Gingival Enlargement 12 32
Gingival Hyperplasia 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3086
MeSH 43 D019214
SNOMED-CT 67 54711002
ICD10 32 K06.1
UMLS 71 C0017566 C0376480

Summaries for Gingival Overgrowth

MalaCards based summary : Gingival Overgrowth, also known as gingival enlargement, is related to fibromatosis, gingival, 1 and gingival fibromatosis. An important gene associated with Gingival Overgrowth is KCNK4 (Potassium Two Pore Domain Channel Subfamily K Member 4), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. The drugs Phenytoin and Sotalol have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and heart, and related phenotypes are homeostasis/metabolism and hematopoietic system

Wikipedia : 74 Gingival enlargement is an increase in the size of the gingiva (gums). It is a common feature of... more...

Related Diseases for Gingival Overgrowth

Diseases related to Gingival Overgrowth via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)
# Related Disease Score Top Affiliating Genes
1 fibromatosis, gingival, 1 32.7 TGFB1 SOS1 MMP2 MMP1 CD36
2 gingival fibromatosis 31.7 TIMP1 TGFB1 SOS1 MMP3 MMP2 MMP1
3 gingivitis 31.6 TIMP1 MMP1 IL6 IL1A
4 periodontitis, chronic 31.6 MMP1 IL6
5 periodontitis 30.9 TIMP1 MMP3 MMP2 MMP1 IL6 IL1A
6 keloid disorder 30.8 TGFB1 CD36
7 aggressive periodontitis 30.5 MMP1 IL6 IL1A
8 biliary atresia 30.5 TIMP1 TGFB1 CCN2
9 odontogenic myxoma 30.5 MMP2 MMP1 DCN CD36
10 idiopathic neutropenia 30.5 TGFB1 IL6 IL1A
11 interstitial lung disease 30.4 TIMP1 TGFB1 IL6 IL1A
12 mucositis 30.3 TGFB1 MMP2 FGF7
13 oral submucous fibrosis 30.3 TIMP1 TGFB1 MMP3 MMP2
14 arthropathy 30.3 MMP3 MMP2 MMP1 IL6
15 gingival disease 30.3 TIMP1 TGFB1 SOS1 MMP1 IL6 IL1A
16 lung disease 30.2 TGFB1 RET IL6 IL1A FGF7
17 periodontitis, aggressive, 1 30.2 MMP1 IL1A
18 endometriosis 30.1 TIMP1 MMP3 MMP2 MMP1 IL6
19 skin disease 29.9 MMP1 IL6 IL1A FGF7 FGF2
20 facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome 12.7
21 amelogenesis imperfecta, type ig 11.4
22 overgrowth syndrome 11.3
23 zimmermann-laband syndrome 1 11.2
24 zimmermann-laband syndrome 2 11.2
25 zimmermann-laband syndrome 3 11.2
26 superior limbic keratoconjunctivitis 10.6 MMP3 MMP1
27 ocular cicatricial pemphigoid 10.5 TGFB1 CD36 CCN2
28 leukoregulin 10.5 TGFB1 IL1A
29 ureteral disease 10.5 TGFB1 IL6 CCN2
30 mckusick-kaufman syndrome 10.5 TGFB1 IL6 CCN2
31 peyronie's disease 10.5 TGFB1 IL6 DCN
32 dupuytren contracture 10.5 TGFB1 FGF2 DCN
33 chronic venous insufficiency 10.5 TIMP1 TGFB1 MMP1
34 collagenous colitis 10.5 TIMP1 MMP1 CCN2
35 acute transverse myelitis 10.5 MMP2 IL6
36 differentiated thyroid carcinoma 10.5 TGFB1 RET CD36
37 tendinopathy 10.5 MMP3 MMP1
38 indolent myeloma 10.5 IL6 IL1A
39 gastroschisis 10.5 MMP3 MMP1 IL6
40 viral meningitis 10.5 MMP3 MMP1 IL6
41 dry eye syndrome 10.4 IL6 FGF7 FGF2
42 scleroderma, familial progressive 10.4 CD36 CCN2
43 tendinitis 10.4 PDGFB MMP3 IL6
44 non-alcoholic steatohepatitis 10.4 TGFB1 IL6 CD36 CCN2
45 carpal tunnel syndrome 10.4 TGFB1 IL6 FGF2 CCN2
46 nephrogenic systemic fibrosis 10.4 TIMP1 TGFB1 DCN CCN2
47 clonorchiasis 10.4 TGFB1 CTSL CTSB
48 chronic graft versus host disease 10.4 IL1A CD36
49 appendicitis 10.4 TIMP1 MMP3 IL6
50 posterior urethral valves 10.4 TGFB1 IL6

Graphical network of the top 20 diseases related to Gingival Overgrowth:



Diseases related to Gingival Overgrowth

Symptoms & Phenotypes for Gingival Overgrowth

MGI Mouse Phenotypes related to Gingival Overgrowth:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.42 CCN2 CD36 CTSB DCN FGF2 FGF7
2 hematopoietic system MP:0005397 10.36 CD36 DCN FGF2 FGF7 IL1A IL6
3 cardiovascular system MP:0005385 10.34 CCN2 CD36 FAM20A FGF2 IL1A IL6
4 growth/size/body region MP:0005378 10.34 CCN2 CD36 CTSB DCN FAM20A FGF7
5 immune system MP:0005387 10.32 CD36 CTSB DCN FGF7 IL1A IL6
6 mortality/aging MP:0010768 10.25 CCN2 CD36 CTSB DCN FAM20A FGF2
7 endocrine/exocrine gland MP:0005379 10.24 CCN2 CD36 CTSB DCN IL6 ITGA2
8 integument MP:0010771 10.16 CCN2 CTSB DCN FGF7 IL1A IL6
9 digestive/alimentary MP:0005381 10.15 CCN2 CD36 CTSB DCN IL6 RET
10 nervous system MP:0003631 10.1 CD36 CTSB FGF2 FGF7 IL6 KCNK4
11 neoplasm MP:0002006 10.07 CTSB DCN FGF2 IL1A IL6 MMP1
12 muscle MP:0005369 10.06 CD36 DCN FGF2 IL6 MMP2 PDGFB
13 renal/urinary system MP:0005367 9.91 CD36 CTSB DCN FAM20A FGF7 IL6
14 respiratory system MP:0005388 9.81 CCN2 DCN FAM20A IL6 MMP2 PDGFB
15 skeleton MP:0005390 9.73 CCN2 CD36 DCN FAM20A FGF2 FGF7
16 vision/eye MP:0005391 9.32 CCN2 CD36 DCN FGF2 FGF7 IL6

Drugs & Therapeutics for Gingival Overgrowth

Drugs for Gingival Overgrowth (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Sotalol Approved Phase 4 3930-20-9, 959-24-0 5253
3 Anticonvulsants Phase 4
4 Sodium Channel Blockers Phase 4
5 Diuretics, Potassium Sparing Phase 4
6 Adrenergic Agents Phase 4
7 Adrenergic Antagonists Phase 4
8 Sympatholytics Phase 4
9 Anti-Arrhythmia Agents Phase 4
10 Adrenergic beta-Antagonists Phase 4
11 Neurotransmitter Agents Phase 4
12
leucovorin Approved Phase 3 58-05-9 6006 143
13
Tacrolimus Approved, Investigational Phase 3 104987-11-3 445643 439492 6473866
14
Clotrimazole Approved, Vet_approved Phase 2, Phase 3 23593-75-1 2812
15
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
16
Sirolimus Approved, Investigational Phase 2, Phase 3 53123-88-9 5284616 6436030 46835353
17
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
18
Tretinoin Approved, Investigational, Nutraceutical Phase 2, Phase 3 302-79-4 444795 5538
19 Micronutrients Phase 3
20 Vitamins Phase 3
21 Trace Elements Phase 3
22 Vitamin B Complex Phase 3
23 Hematinics Phase 3
24 Folate Phase 3
25 Nutrients Phase 3
26 Vitamin B9 Phase 3
27 Cyclosporins Phase 3
28 Calcineurin Inhibitors Phase 3
29 Immunologic Factors Phase 2, Phase 3
30 Immunosuppressive Agents Phase 2, Phase 3
31 Anti-Infective Agents Phase 2, Phase 3
32 Anti-Bacterial Agents Phase 2, Phase 3
33 Antifungal Agents Phase 2, Phase 3
34 Antibiotics, Antitubercular Phase 2, Phase 3
35
Mycophenolic acid Approved Phase 2 24280-93-1 446541
36 Antitubercular Agents Phase 2
37 Dermatologic Agents Phase 2
38 Antirheumatic Agents Phase 2
39 abobotulinumtoxinA Phase 1
40 Botulinum Toxins Phase 1
41 Botulinum Toxins, Type A Phase 1
42 incobotulinumtoxinA Phase 1
43
Lidocaine Approved, Vet_approved 137-58-6 3676
44
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713
45
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
46
Methylene blue Approved, Investigational 61-73-4
47
Trichostatin A Experimental 58880-19-6
48 Anesthetics
49 Chlorhexidine gluconate
50 Anesthetics, Local

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Phenytoin as an Augmentation for SSRI Failures: A Controlled Study Completed NCT00146237 Phase 4 phenytoin
2 A Prospective, Multi-Center, Randomized, Open Label Trial to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Not yet recruiting NCT02347111 Phase 4 Flecainide;Sotalol
3 Effect of Low Dose Oral Folic Acid Supplementation on Phenytoin Induced Gingival Overgrowth: A Randomized Double Blind Controlled Trial. Completed NCT00781196 Phase 3 folic acid;placebo
4 A Multicenter, Single-arm, Open, Conversion Study From a Cyclosporine (CyA) Based Immunosuppressive Regimen to a Tacrolimus Modified Release, FK506E (MR4), Based Immunosuppressive Regimen in Kidney Transplant Subjects (CONCERTO: Converting Cyclosporine to FK506E (MR4) in Renal Transplantation) Completed NCT00481481 Phase 3 tacrolimus
5 Sirolimus Combined With All Trans Retinoic Acid for the Treatment of Auto-Immune Anemia Not yet recruiting NCT04324411 Phase 2, Phase 3 sirolimus and ATRA
6 A Randomized Trial for the Treatment of Relapsing Aplastic Anemia With Mycophenolate Mofetil (MMF) and Cyclosporine (CSA) Completed NCT00005935 Phase 2 Mycophenolate mofetil;Cyclosporine
7 Evaluating Lip Repositioning for the Treatment of Excess Gingival Display With and Without Pretreatment With Botox: a Randomized Clinical Trial Not yet recruiting NCT04030767 Phase 1 Botox Injectable Product
8 The Clinical Application of Diode Laser in Gingival Enlargement Related to Orthodontics Unknown status NCT01286298
9 Evaluation of Temperature and Healing in Treatment of Gingival Enlargement Using Different Gingivectomy Techniques Completed NCT04016064
10 Development and Validation of the Periodontal Aesthetic Perception Scale in Patients With Periodontal Problems Completed NCT03436537
11 The Determination of the Operative Temperature Levels Using Er:YAG Laser and Diode Laser Supported Resective Gingival Surgery and the Clinical and Biochemical Evaluation of it's Effect on Postoperative Imflammation, Epithelization and Pain Completed NCT04304391
12 Scalpel Versus Laser Gingivectomy in the Management of Periodontal Health During Orthodontic Treatment: a Randomized Controlled Clinical Trial Completed NCT03514316
13 Genes Associated With Hereditary and Drug-Induced Gingival Overgrowth Completed NCT00104026
14 The Evaluation of Soft Tissue Wound Healing Following Different Gingivectomy Applications: A Prospective Randomized Clinical Trial Completed NCT03435068
15 Efficacy of Low-level Laser Therapy, Hyaluronic Acid Gel and Herbal Gel as Adjunctive Tools in Gingivectomy Wound Healing-A Randomised Comparative Clinical and Histological Study Completed NCT03569683
16 The Effect of Using Two Different Suturing Techniques on Free Gingival Marginal Stability After Esthetic Crown Lengthening for Treatment of Gummy Smile (Randomized Clinical Trial) Completed NCT04219436
17 Open-flap Versus Flapless Esthetic Crown Lengthening: 12-month Clinical Outcomes of a Randomized Controlled Clinical Trial Completed NCT01821157
18 Biomarker for Hyaline Fibromatosis Syndrome - An International, Multicenter, Epidemiological Protocol Active, not recruiting NCT03196115
19 Oral Findings In A Group of Egyptian Children With Attention Deficit Hyperactivity Disorder: A Cross-Sectional Study Not yet recruiting NCT03887039
20 Oral Health Educational Program for Knowledge, Attitude and Practice (KAP) of Oral Health Among a Group of Egyptian School Girls in Ras Sedr - South Sinai Not yet recruiting NCT03740269
21 Oral Findings in a Group of Egyptian Pediatric Patients at Endstage Renal Disease Either on Haemodialysis or After Renal Transplantation Not yet recruiting NCT03590067
22 Efficacy of Photodynamic Therapy and Periodontal Treatment in Patients With Gingivitis and Fixed Orthodontic Appliances: Protocol of Randomized, Controlled, Double-blind Study Not yet recruiting NCT04037709

Search NIH Clinical Center for Gingival Overgrowth

Cochrane evidence based reviews: gingival overgrowth

Genetic Tests for Gingival Overgrowth

Genetic tests related to Gingival Overgrowth:

# Genetic test Affiliating Genes
1 Gingival Overgrowth 29

Anatomical Context for Gingival Overgrowth

MalaCards organs/tissues related to Gingival Overgrowth:

40
Kidney, Liver, Heart, Myeloid, Bone, Salivary Gland, Endothelial

Publications for Gingival Overgrowth

Articles related to Gingival Overgrowth:

(show top 50) (show all 1443)
# Title Authors PMID Year
1
Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth. 54 61
19778329 2010
2
Expression of metalloproteinases and their tissue inhibitors in gingiva affected by hereditary gingival fibromatosis: analysis of three cases within a family. 61 54
19453853 2009
3
[Connective tissue growth factors, CTGF and Cyr61 in drug-induced gingival overgrowth--an animal model]. 54 61
20209781 2008
4
Gingival crevicular fluid transforming growth factor-beta1 in cyclosporine and tacrolimus treated renal transplant patients without gingival overgrowth. 61 54
18342291 2008
5
Detection of gingival crevicular fluid cytokines in children and adolescents with and without fixed orthodontic appliances. 54 61
18568476 2008
6
Transforming growth factor-beta1 gene expression and cyclosporine A-induced gingival overgrowth: a pilot study. 54 61
18355347 2008
7
Gingival crevicular fluid and serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 levels in renal transplant patients undergoing different immunosuppressive therapy. 54 61
18269661 2008
8
Do MMP-1 levels of gingival fibroblasts have a role in the gingival overgrowth of cyclosporine-treated patients? 61 54
18261580 2008
9
Gingival fibroblasts grown from cyclosporin-treated patients show a reduced production of matrix metalloproteinase-1 (MMP-1) compared with normal gingival fibroblasts, and cyclosporin down-regulates the production of MMP-1 stimulated by pro-inflammatory cytokines. 61 54
17956473 2007
10
Stimulation of cells derived from nifedipine-induced gingival overgrowth with Porphyromonas gingivalis, lipopolysaccharide, and interleukin-1beta. 61 54
17959904 2007
11
Relationship between IL-1A polymorphisms and gingival overgrowth in renal transplant recipients receiving Cyclosporin A. 61 54
16965524 2006
12
Elevated gene expression of MMP-1, MMP-10, and TIMP-1 reveal changes of molecules involved in turn-over of extracellular matrix in cyclosporine-induced gingival overgrowth. 54 61
16670920 2006
13
Matrix metalloproteinase-1 gene polymorphism in renal transplant patients with and without gingival enlargement. 54 61
16945025 2006
14
Elevated levels of gene expression for collagen and decorin in human gingival overgrowth. 54 61
16820039 2006
15
Mechanism of cyclosporine-induced overgrowth in gingiva. 54 61
16723647 2006
16
Alpha 2 integrin +807 polymorphism in drug-induced gingival overgrowth. 54 61
16304451 2005
17
Cyclosporin but not tacrolimus significantly increases salivary cytokine contents in rats. 61 54
16171442 2005
18
Inhibition of growth of human gingival fibroblasts by chimeric DNA-RNA hammerhead ribozyme targeting transforming growth factor-beta 1. 54 61
16101357 2005
19
The effect of IL-1alpha and nifedipine on cell proliferation and DNA synthesis in cultured human gingival fibroblasts. 61 54
16050491 2005
20
Plasma TGF-beta1 as a risk factor for gingival overgrowth. 54 61
15367190 2004
21
Long-term cyclosporin A exposure suppresses cathepsin-B and -L activity in gingival fibroblasts. 54 61
15324353 2004
22
Regulation of keratinocyte growth factor and scatter factor in cyclosporin-induced gingival overgrowth. 54 61
15250830 2004
23
Effect of cyclosporin A on human gingival fibroblast collagen turnover in relation to the development of gingival overgrowth: an in vitro study. 54 61
15183848 2004
24
Crevicular fluid levels of TGFbeta1 in drug-induced gingival overgrowth. 61 54
15041490 2004
25
Gene expression of extracellular matrix proteoglycans in human cyclosporin-induced gingival overgrowth. 61 54
14974815 2003
26
Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice. 61 54
12466121 2002
27
Evaluation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 levels in gingival fibroblasts of cyclosporin A-treated patients. 61 54
12479630 2002
28
Expression of matrix metalloproteinases in cyclosporin-treated gingival fibroblasts is regulated by transforming growth factor (TGF)-beta1 autocrine stimulation. 54 61
12479636 2002
29
Phenytoin-mediated androgen metabolism in gingival fibroblasts. Effects of the antiandrogen finasteride and the alkaline phosphatase inhibitor levamisole. 61 54
12445228 2002
30
Cytokine regulation of gingival fibroblast lysyl oxidase, collagen, and elastin. 61 54
11895278 2002
31
The effects of human mast-cell products and of phenytoin on androgen 5alpha-reductase expression in human gingival fibroblasts. 61 54
11420057 2001
32
Connective tissue growth factor in drug-induced gingival overgrowth. 61 54
11495141 2001
33
Upregulation of keratinocyte growth factor in cyclosporin A-induced gingival overgrowth. 61 54
11453236 2001
34
The influence of transforming growth factor-beta1 gene polymorphisms on the severity of gingival overgrowth associated with concomitant use of cyclosporin A and a calcium channel blocker. 61 54
11453244 2001
35
Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-beta1 and detection in human gingiva. 61 54
10616214 1999
36
Width/length ratios of normal clinical crowns of the maxillary anterior dentition in man. 61 54
10100040 1999
37
Immunolocalization of collagenase (MMP-1) and stromelysin (MMP-3) in the gingival tissues of organ transplant patients medicated with cyclosporin. 54 61
9696255 1998
38
Increased bFGF level in the serum of patients with phenytoin-induced gingival overgrowth. 54 61
9477019 1998
39
Gingival fibroblast response to cyclosporin A and transforming growth factor beta 1. 61 54
9524320 1998
40
Increased proliferation, collagen, and fibronectin production by hereditary gingival fibromatosis fibroblasts. 54 61
9203095 1997
41
Phenytoin and cyclosporine A specifically regulate macrophage phenotype and expression of platelet-derived growth factor and interleukin-1 in vitro and in vivo: possible molecular mechanism of drug-induced gingival hyperplasia. 61 54
9029455 1997
42
PDGF-B producing cells and PDGF-B gene expression in normal gingival and cyclosporine A-induced gingival overgrowth. 61 54
8708959 1996
43
Cyclosporine A upregulates platelet-derived growth factor B chain in hyperplastic human gingiva. 54 61
8708960 1996
44
Effect of phenytoin on interleukin-1 beta production in human gingival fibroblasts challenged to tumor necrosis factor alpha in vitro. 61 54
8653494 1996
45
Phenytoin increases gene expression for platelet-derived growth factor B chain in macrophages and monocytes. 61 54
8463938 1993
46
Extracellular matrix analysis of nifedipine-induced gingival overgrowth: immunohistochemical distribution of different collagen types as well as the glycoprotein fibronectin. 61 54
8426277 1993
47
SPOCK1 is a novel inducer of epithelial to mesenchymal transition in drug-induced gingival overgrowth. 61
32555336 2020
48
Oral Manifestations and Complications in Childhood Acute Myeloid Leukemia. 61
32575613 2020
49
Amlodipine-induced gingival enlargement: A case report. 61
31055091 2020
50
Nonsyndromic hereditary gingival fibromatosis: Characterization of a family and review of genetic etiology. 61
32413193 2020

Variations for Gingival Overgrowth

ClinVar genetic disease variations for Gingival Overgrowth:

6 ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 KCNK4 NM_033310.3(KCNK4):c.515C>A (p.Ala172Glu)SNV Pathogenic 560221 rs1565369746 11:64064979-64064979 11:64297507-64297507
2 KCNK4 NM_033310.3(KCNK4):c.730G>C (p.Ala244Pro)SNV Pathogenic 560222 rs1189909394 11:64065650-64065650 11:64298178-64298178
3 RET NM_020975.6(RET):c.2753T>C (p.Met918Thr)SNV Pathogenic 13919 rs74799832 10:43617416-43617416 10:43121968-43121968
4 46;XY;t(3;17)(p14.3;q24.3)dnTranslocation Likely pathogenic 267799

Copy number variations for Gingival Overgrowth from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 116297 17 64200000 70900000 Copy number Gingival hyperplasia

Expression for Gingival Overgrowth

Search GEO for disease gene expression data for Gingival Overgrowth.

Pathways for Gingival Overgrowth

Pathways related to Gingival Overgrowth according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 TIMP1 TGFB1 SOS1 RET PDGFB MMP3
2
Show member pathways
13.87 TIMP1 TGFB1 SOS1 PDGFB MMP2 ITGA2
3
Show member pathways
13.86 TIMP1 TGFB1 SOS1 PDGFB ITGA2 IL6
4
Show member pathways
13.71 TIMP1 TGFB1 SOS1 PDGFB MMP3 MMP2
5
Show member pathways
13.59 TIMP1 TGFB1 SOS1 PDGFB KCNK4 IL6
6
Show member pathways
13.58 TIMP1 TGFB1 SOS1 PDGFB ITGA2 IL6
7
Show member pathways
13.53 TGFB1 SOS1 RET PDGFB MMP2 ITGA2
8
Show member pathways
13.44 TIMP1 TGFB1 SOS1 PDGFB ITGA2 IL6
9
Show member pathways
13.36 TIMP1 TGFB1 SOS1 PDGFB IL6 FGF7
10
Show member pathways
13.35 TIMP1 TGFB1 SOS1 PDGFB MMP1 ITGA2
11
Show member pathways
13.33 TIMP1 TGFB1 PDGFB IL6 IL1A FGF7
12
Show member pathways
13.3 TIMP1 TGFB1 SOS1 PDGFB IL6 FGF7
13
Show member pathways
13.18 TIMP1 TGFB1 SOS1 RET PDGFB MMP3
14
Show member pathways
13.09 TIMP1 TGFB1 SOS1 PDGFB IL6 FGF7
15
Show member pathways
13.08 TIMP1 TGFB1 SOS1 PDGFB ITGA2 IL6
16
Show member pathways
13.03 SOS1 PDGFB ITGA2 IL6 FGF7 FGF2
17
Show member pathways
12.88 TGFB1 SOS1 RET PDGFB MMP3
18
Show member pathways
12.87 TGFB1 IL6 IL1A CTSL CTSB
19 12.8 TGFB1 SOS1 PDGFB IL1A FGF7 FGF2
20 12.79 TGFB1 SOS1 RET PDGFB MMP2 MMP1
21
Show member pathways
12.73 TIMP1 TGFB1 PDGFB IL6 IL1A FGF7
22
Show member pathways
12.72 SOS1 PDGFB MMP2 FGF7 FGF2
23 12.67 SOS1 PDGFB ITGA2 FGF7 FGF2
24
Show member pathways
12.65 TGFB1 SOS1 PDGFB IL6 FGF2
25
Show member pathways
12.65 TIMP1 SOS1 PDGFB MMP2 IL6 FGF2
26
Show member pathways
12.55 TIMP1 TGFB1 PDGFB MMP3 MMP2 MMP1
27
Show member pathways
12.54 TGFB1 SOS1 PDGFB ITGA2 FGF2
28 12.35 TGFB1 SOS1 MMP2 ITGA2 FGF2 DCN
29
Show member pathways
12.35 TIMP1 TGFB1 SOS1 PDGFB ITGA2 IL6
30
Show member pathways
12.34 TGFB1 SOS1 MMP2 IL6
31
Show member pathways
12.34 TIMP1 SOS1 MMP3 MMP1
32
Show member pathways
12.33 SOS1 IL6 IL1A FGF2
33
Show member pathways
12.27 TIMP1 TGFB1 PDGFB IL6 IL1A FGF7
34 12.25 TGFB1 SOS1 MMP2 MMP1 IL6
35 12.14 PDGFB MMP2 IL1A CTSL
36 12.13 TGFB1 PDGFB IL6 FGF7 FGF2
37 12.11 TGFB1 SOS1 MMP1 ITGA2
38 11.96 TGFB1 MMP2 IL6 IL1A
39
Show member pathways
11.95 TIMP1 MMP3 MMP2 MMP1
40 11.95 ITGA2 IL6 IL1A CD36
41 11.95 TGFB1 PDGFB IL6 FGF2 DCN
42 11.91 TIMP1 TGFB1 MMP3 MMP2 FGF2
43 11.88 TGFB1 MMP3 MMP1 IL6 IL1A CTSL
44
Show member pathways
11.84 TIMP1 SOS1 IL6
45
Show member pathways
11.72 MMP3 MMP2 MMP1 IL6 IL1A
46 11.71 TIMP1 MMP3 MMP2 MMP1
47 11.66 TIMP1 TGFB1 SOS1 PDGFB ITGA2 IL6
48 11.65 TGFB1 ITGA2 DCN
49 11.63 TGFB1 SOS1 MMP1 IL6
50 11.6 TGFB1 SOS1 CCN2

GO Terms for Gingival Overgrowth

Cellular components related to Gingival Overgrowth according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 TIMP1 TGFB1 PDGFB MMP3 MMP2 MMP1
2 collagen-containing extracellular matrix GO:0062023 9.8 TGFB1 PDGFB MMP2 DCN CTSL CTSB
3 extracellular matrix GO:0031012 9.7 TIMP1 TGFB1 MMP3 MMP2 MMP1 DCN
4 platelet alpha granule lumen GO:0031093 9.54 TIMP1 TGFB1 PDGFB
5 extracellular space GO:0005615 9.47 TIMP1 TGFB1 PDGFB MMP3 MMP2 IL6
6 endolysosome lumen GO:0036021 9.32 CTSL CTSB

Biological processes related to Gingival Overgrowth according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.09 TGFB1 RET PDGFB IL6 FGF7 FGF2
2 positive regulation of cell proliferation GO:0008284 10.05 TIMP1 TGFB1 PDGFB IL6 FGF7 FGF2
3 positive regulation of gene expression GO:0010628 10.04 TGFB1 RET PDGFB IL6 IL1A CD36
4 negative regulation of gene expression GO:0010629 10 TGFB1 PDGFB FGF2 CD36 CCN2
5 cellular protein metabolic process GO:0044267 9.96 TIMP1 MMP2 MMP1 IL6
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 TGFB1 PDGFB FGF2 CD36 CCN2
7 MAPK cascade GO:0000165 9.95 TGFB1 SOS1 RET PDGFB FGF7 FGF2
8 aging GO:0007568 9.94 TIMP1 TGFB1 DCN CCN2
9 positive regulation of protein kinase B signaling GO:0051897 9.93 TGFB1 RET PDGFB FGF7 FGF2
10 platelet degranulation GO:0002576 9.89 TIMP1 TGFB1 PDGFB CD36
11 response to wounding GO:0009611 9.85 TGFB1 PDGFB FGF7 CCN2
12 positive regulation of MAPK cascade GO:0043410 9.85 RET PDGFB IL6 FGF2 CD36
13 cellular response to mechanical stimulus GO:0071260 9.84 TGFB1 KCNK4 ITGA2
14 fibroblast growth factor receptor signaling pathway GO:0008543 9.84 FGF7 FGF2 CCN2
15 positive regulation of MAP kinase activity GO:0043406 9.83 TGFB1 PDGFB FGF2
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 PDGFB MMP2 ITGA2 IL6
17 wound healing GO:0042060 9.83 TIMP1 TGFB1 ITGA2 FGF2 DCN
18 positive regulation of protein complex assembly GO:0031334 9.82 TGFB1 MMP3 MMP1
19 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.81 PDGFB MMP2 FGF2
20 positive chemotaxis GO:0050918 9.81 PDGFB FGF7 FGF2
21 positive regulation of blood vessel endothelial cell migration GO:0043536 9.8 TGFB1 PDGFB FGF2
22 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.8 TGFB1 PDGFB IL6 FGF7 CD36
23 extracellular matrix organization GO:0030198 9.8 PDGFB MMP3 MMP2 MMP1 ITGA2 FGF2
24 toll-like receptor signaling pathway GO:0002224 9.79 CTSL CTSB CD36
25 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.78 TGFB1 PDGFB FGF2
26 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.76 TGFB1 PDGFB FGF2
27 positive regulation of vascular endothelial growth factor production GO:0010575 9.75 TGFB1 IL6 IL1A
28 positive regulation of collagen biosynthetic process GO:0032967 9.74 TGFB1 ITGA2 CCN2
29 extracellular matrix disassembly GO:0022617 9.72 TIMP1 MMP3 MMP2 MMP1 CTSL
30 cellular response to thyroid hormone stimulus GO:0097067 9.68 CTSL CTSB
31 cell activation GO:0001775 9.68 TIMP1 TGFB1
32 positive regulation of phagocytosis, engulfment GO:0060100 9.68 ITGA2 CD36
33 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.67 TGFB1 IL6
34 regulation of neuroinflammatory response GO:0150077 9.67 MMP3 IL6
35 paracrine signaling GO:0038001 9.65 PDGFB FGF2
36 connective tissue development GO:0061448 9.62 TGFB1 CCN2
37 positive regulation of cell division GO:0051781 9.55 TGFB1 PDGFB IL1A FGF7 FGF2
38 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.54 TIMP1 TGFB1 IL1A
39 collagen catabolic process GO:0030574 9.35 MMP3 MMP2 MMP1 CTSL CTSB
40 cytokine-mediated signaling pathway GO:0019221 9.32 TIMP1 TGFB1 SOS1 MMP3 MMP2 MMP1

Molecular functions related to Gingival Overgrowth according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.32 TIMP1 TGFB1 SOS1 RET PDGFB MMP3
2 peptidase activity GO:0008233 9.8 MMP3 MMP2 MMP1 CTSL CTSB
3 endopeptidase activity GO:0004175 9.56 MMP3 MMP2 MMP1 CTSB
4 cytokine activity GO:0005125 9.55 TIMP1 TGFB1 IL6 IL1A FGF2
5 chemoattractant activity GO:0042056 9.5 PDGFB FGF7 FGF2
6 collagen binding GO:0005518 9.35 PDGFB ITGA2 DCN CTSL CTSB
7 growth factor activity GO:0008083 9.17 TIMP1 TGFB1 PDGFB IL6 FGF7 FGF2

Sources for Gingival Overgrowth

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
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68 SNOMED-CT via HPO
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70 Tocris
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