MCID: GNG012
MIFTS: 53

Gingival Overgrowth

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Gingival Overgrowth

MalaCards integrated aliases for Gingival Overgrowth:

Name: Gingival Overgrowth 12 29 55 6 44 15
Gingival Enlargement 12
Gingival Hyperplasia 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3086
ICD10 33 K06.1
MeSH 44 D019214
SNOMED-CT 68 54711002

Summaries for Gingival Overgrowth

MalaCards based summary : Gingival Overgrowth, also known as gingival enlargement, is related to fibromatosis, gingival, 1 and gingival fibromatosis. An important gene associated with Gingival Overgrowth is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. The drugs Ethanol and Cetylpyridinium have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 76 Gingival enlargement, (also termed gingival overgrowth, hypertrophic gingivitis, gingival hyperplasia,... more...

Related Diseases for Gingival Overgrowth

Diseases related to Gingival Overgrowth via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 fibromatosis, gingival, 1 31.8 CD36 MMP1 MMP2 SOS1 TGFB1
2 gingival fibromatosis 31.3 CD36 ITGA2 MMP1 MMP2 MMP3 SOS1
3 aggressive periodontitis 30.4 IL1A IL6 MMP1
4 keloids 30.2 CD36 MMP1 TGFB1
5 periodontitis, chronic 30.0 IL6 MMP1
6 periodontitis 29.9 IL1A IL6 MMP1 MMP2 MMP3 TIMP1
7 idiopathic neutropenia 29.9 IL1A IL6 TGFB1
8 odontogenic myxoma 29.8 CD36 DCN MMP1 MMP2
9 periodontal disease 29.3 IL1A IL6 MMP1 MMP2 MMP3 TIMP1
10 amelogenesis imperfecta, type ig 11.3
11 epulis 11.0
12 superior limbic keratoconjunctivitis 10.2 MMP1 MMP3
13 laryngitis 10.2 FGF2 IL6 TGFB1
14 ocular cicatricial pemphigoid 10.2 CCN2 CD36 TGFB1
15 diabetic foot ulcers 10.2 IL6 PDGFB TGFB1
16 eosinophilic granuloma 10.2 CD36 DCN
17 otosclerosis 10.2 CD36 IL6 TGFB1
18 differentiated thyroid carcinoma 10.2 CD36 RET TGFB1
19 renal fibrosis 10.2 CCN2 CD36 TGFB1
20 interstitial keratitis 10.2 CD36 DCN
21 urinary system disease 10.2 CCN2 IL6 TGFB1
22 dupuytren contracture 10.2 DCN FGF2 TGFB1
23 neuroma 10.2 FGF2 RET TGFB1
24 exanthema subitum 10.2 FGF2 IL6 TIMP1
25 vitreoretinopathy, neovascular inflammatory 10.2 FGF2 TGFB1 TIMP1
26 epilepsy 10.1
27 chronic ulcer of skin 10.1 FGF2 MMP1 PDGFB
28 lymph node disease 10.1 IL6 MMP1 MMP3
29 crouzon syndrome 10.1 DCN FGF2 TGFB1
30 transient arthritis 10.1 IL1A IL6 TGFB1
31 localized scleroderma 10.1 DCN IL6 MMP1 TGFB1
32 bronchiolitis obliterans 10.1 IL6 PDGFB TIMP1
33 joint disorders 10.1 IL6 MMP3 TIMP1
34 pulpitis 10.1 IL1A IL6 MMP1
35 pulmonary disease, chronic obstructive 10.1 IL6 MMP1 TGFB1 TIMP1
36 synovitis 10.1 IL6 MMP1 MMP3
37 carotid artery disease 10.1 MMP1 MMP3 TIMP1
38 nephrogenic systemic fibrosis 10.1 CCN2 DCN TGFB1 TIMP1
39 leukoregulin 10.1 IL1A TGFB1
40 microvascular complications of diabetes 1 10.1 CCN2 FGF2 TIMP1
41 kawasaki disease 10.1 IL6 MMP3 TIMP1
42 amelogenesis imperfecta 10.1
43 lymphoma 10.1
44 tuberous sclerosis 10.1
45 gingivitis 10.1
46 hypertrichosis 10.1
47 tendinosis 10.0 DCN MMP1 MMP3 TIMP1
48 sturge-weber syndrome 10.0
49 leukemia 10.0
50 interstitial lung disease 10.0 IL1A IL6 TGFB1 TIMP1

Graphical network of the top 20 diseases related to Gingival Overgrowth:



Diseases related to Gingival Overgrowth

Symptoms & Phenotypes for Gingival Overgrowth

MGI Mouse Phenotypes related to Gingival Overgrowth:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.4 CCN2 CD36 CTSB DCN FGF2 IL1A
2 cardiovascular system MP:0005385 10.34 CCN2 CD36 FAM20A FGF2 IL1A IL6
3 hematopoietic system MP:0005397 10.32 CD36 DCN FGF2 IL1A IL6 ITGA2
4 growth/size/body region MP:0005378 10.3 CCN2 CD36 CTSB DCN FAM20A IL6
5 immune system MP:0005387 10.29 CD36 CTSB DCN IL1A IL6 MMP1
6 mortality/aging MP:0010768 10.25 CCN2 CD36 CTSB DCN FAM20A FGF2
7 endocrine/exocrine gland MP:0005379 10.24 CCN2 CD36 CTSB DCN IL6 ITGA2
8 digestive/alimentary MP:0005381 10.15 CCN2 CD36 CTSB DCN IL6 RET
9 integument MP:0010771 10.11 CCN2 CTSB DCN IL1A IL6 ITGA2
10 neoplasm MP:0002006 10.07 CTSB DCN FGF2 IL1A IL6 MMP1
11 muscle MP:0005369 10.06 CD36 DCN FGF2 IL6 MMP2 PDGFB
12 nervous system MP:0003631 10.06 CD36 CTSB FGF2 IL6 KCNK4 MMP2
13 renal/urinary system MP:0005367 9.86 CD36 CTSB DCN FAM20A IL6 PDGFB
14 respiratory system MP:0005388 9.81 CCN2 DCN FAM20A IL6 MMP2 PDGFB
15 skeleton MP:0005390 9.7 CCN2 CD36 DCN FAM20A FGF2 IL6
16 vision/eye MP:0005391 9.28 CCN2 CD36 DCN FGF2 IL6 MMP2

Drugs & Therapeutics for Gingival Overgrowth

Drugs for Gingival Overgrowth (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethanol Approved Phase 4 64-17-5 702
2
Cetylpyridinium Approved Phase 4 7773-52-6
3
Menthol Approved Phase 4 2216-51-5 16666
4
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
5
Thymol Approved Phase 4 89-83-8 6989
6
Eucalyptol Approved, Nutraceutical Phase 4 470-82-6 2758
7 Salicylates Phase 4
8 Pharmaceutical Solutions Phase 4
9 Anti-Infective Agents, Local Phase 4
10 Fluorides Phase 4
11 Anti-Infective Agents Phase 4
12
leucovorin Approved Phase 3 58-05-9 6006 143
13
Phenytoin Approved, Vet_approved Phase 3 57-41-0 1775
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
15 Vitamin B Complex Phase 3
16 Diuretics, Potassium Sparing Phase 3
17 Vitamin B9 Phase 3
18 Anticonvulsants Phase 3
19 Vitamins Phase 3
20 Hematinics Phase 3
21 Sodium Channel Blockers Phase 3
22 Folate Phase 3
23 Micronutrients Phase 3
24 Trace Elements Phase 3
25
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 2713 9552079
26
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
27
Racepinephrine Approved Not Applicable 329-65-7 838
28
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
29
Hyaluronic acid Approved, Vet_approved Not Applicable 9004-61-9 53477741
30 Calcium, Dietary
31 calcium channel blockers
32 Cyclosporins
33 Epinephryl borate Not Applicable
34 Anesthetics, Local Not Applicable
35 Trichostatin A Not Applicable
36 Anesthetics Not Applicable
37 Chlorhexidine gluconate Not Applicable
38
Tin Not Applicable 7440-31-5
39 Viscosupplements Not Applicable
40 Protective Agents Not Applicable
41 Immunologic Factors Not Applicable
42 Adjuvants, Immunologic Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Mouthwashes During Orthodontic Treatment Enrolling by invitation NCT03179735 Phase 4 Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
2 Folic Acid Supplementation in Phenytoin Induced Gingival Overgrowth Completed NCT00781196 Phase 3 folic acid;placebo
3 Diode Laser in Gingival Enlargement Related to Orthodontics Unknown status NCT01286298 Not Applicable
4 Genes Associated With Hereditary and Drug-Induced Gingival Overgrowth Completed NCT00104026
5 Scalpel Versus Laser Gingivectomy in Orthodontic Patients in the Management of Periodontal Health Completed NCT03514316 Not Applicable
6 Comparison Between Laser, Synthetic Gel and Herbal Gel as Topical Agents After Gum Surgery Completed NCT03569683 Not Applicable
7 Soft Tissue Wound Healing Following Different Gingivectomy Techniques Completed NCT03435068 Not Applicable
8 Flapless Esthetic Crown Lengthening for the Treatment of Excessive Gingival Display Completed NCT01821157 Not Applicable
9 Development and Validation of the Periodontal Aesthetic Perception Scale in Patients With Periodontal Problems Completed NCT03436537
10 European Alpha-Mannosidosis Patient Epidemiological Program Recruiting NCT03651245
11 Oral Findings in a Group of Egyptian Pediatric Patients at Endstage Renal Disease Not yet recruiting NCT03590067

Search NIH Clinical Center for Gingival Overgrowth

Cochrane evidence based reviews: gingival overgrowth

Genetic Tests for Gingival Overgrowth

Genetic tests related to Gingival Overgrowth:

# Genetic test Affiliating Genes
1 Gingival Overgrowth 29

Anatomical Context for Gingival Overgrowth

MalaCards organs/tissues related to Gingival Overgrowth:

41
Heart, Kidney, Bone, B Cells, Myeloid, Bone Marrow, Liver

Publications for Gingival Overgrowth

Articles related to Gingival Overgrowth:

(show top 50) (show all 666)
# Title Authors Year
1
Cyclosporine A - Induced gingival overgrowth and proliferating cell nuclear antigen expression in experimental periodontitis. ( 30386719 )
2019
2
Is dental plaque the only etiological factor in Amlodipine induced gingival overgrowth? A systematic review of evidence. ( 29930781 )
2018
3
Influence of 3 calcium channel blockers on gingival overgrowth in a population of severe refractory hypertensive patients. ( 29687449 )
2018
4
Reversal of drug-induced gingival overgrowth by UV-mediated apoptosis of gingival fibroblasts - an in vitro study. ( 29427738 )
2018
5
High-power diode laser on management of drug-induced gingival overgrowth: Report of two cases and long-term follow-up. ( 29351498 )
2018
6
Immunohistochemical Analysis of the Role Connective Tissue Growth Factor in Drug-induced Gingival Overgrowth in Response to Phenytoin, Cyclosporine, and Nifedipine. ( 29629324 )
2018
7
Calcium channel blocker-induced gingival overgrowth. ( 30146567 )
2018
8
Nonsurgical Periodontal Treatment by Erbium:Yag Laser Promotes Regression of Gingival Overgrowth in Patient Taking Cyclosporine A: A Case Report. ( 30311849 )
2018
9
Diffuse gingival enlargement: an unusual diagnostic clue for pulmonary tuberculosis. ( 30507411 )
2018
10
Gingival enlargement in children with sickle cell disease. ( 29576570 )
2018
11
Tuberous Sclerosis Complex with Gingival Enlargement in an Adolescent. ( 29482692 )
2018
12
Gingival Enlargement Caused by Vitamin C Deficiency (Scurvy) in a Boy. ( 29663975 )
2018
13
Leukemic gingival enlargement: A case report and review of literature. ( 29491612 )
2018
14
Phenytoin activates Smad3 phosphorylation and periostin expression in drug-induced gingival enlargement. ( 29916554 )
2018
15
Nonsurgical periodontal treatment and prosthetic rehabilitation of a renal transplant patient with gingival enlargement: a case report with 2-year follow-up. ( 30126388 )
2018
16
Change of TGF-β1 Gene Expression and TGF-β1 Protein Level in Gingival Crevicular Fluid and Identification of Plaque Bacteria in a Patient with Recurrent Localized Gingival Enlargement before and after Gingivectomy. ( 30174961 )
2018
17
Allele-specific polymerase chain reaction for the detection of single nucleotide polymorphism in amlodipine-induced gingival enlargement. ( 28656587 )
2018
18
Systematic review of cyclosporin A-induced gingival overgrowth and genetic predisposition. ( 28439573 )
2017
19
Lack of Association Between TGF-I^1 and MDR1 Genetic Polymorphisms and Cyclosporine-Induced Gingival Overgrowth in Kidney Transplant Recipients: A Meta-analysis. ( 28736004 )
2017
20
Epithelial to mesenchymal transition in Cyclosporine A-induced rat gingival overgrowth. ( 28472720 )
2017
21
Mulberry-Shaped Gingival Overgrowth Induced by Amlodipine and Cyclosporine. ( 29208265 )
2017
22
Oral squamous cell carcinoma masquerading as gingival overgrowth. ( 28932153 )
2017
23
Lack of pathogenic mutations in SOS1 gene in phenytoin-induced gingival overgrowth patients. ( 28433619 )
2017
24
Gingival overgrowth: Part 2: management strategies. ( 28184072 )
2017
25
Phenytoin-induced gingival overgrowth caused by death receptor pathway malfunction. ( 28160766 )
2017
26
A Rare Case of Digoxin Associated Gingival Overgrowth. ( 28571294 )
2017
27
On the Cellular and Molecular Mechanisms of Drug-Induced Gingival Overgrowth. ( 28868093 )
2017
28
Gingival overgrowth: Part 1: aetiology and clinical diagnosis. ( 28127024 )
2017
29
A novel gingival overgrowth mouse model induced by the combination of CsA and ligature-induced inflammation. ( 28274836 )
2017
30
Gingival enlargement unveiling Crohn's disease - A report of a rarefied case. ( 29456308 )
2017
31
Drug-induced gingival overgrowth after renal transplantation. ( 28656480 )
2017
32
Drug-induced Gingival Overgrowth: What You Need to Know! ( 30457313 )
2017
33
Cryotherapy as a conservative treatment modality for gingival enlargement in a patient with Sturge-Weber Syndrome. ( 28580218 )
2017
34
Comparative evaluation of oral hygiene status and gingival enlargement among epileptic and healthy children as related to various antiepileptic drugs. ( 29398857 )
2017
35
Tuberculous gingival enlargement: A rare clinical manifestation. ( 29398862 )
2017
36
Gingival enlargement in a pregnant woman with acute monocytic leukaemia: a case report. ( 28466503 )
2017
37
Gingival enlargement in orthodontic patients: Effect of treatment duration. ( 28962731 )
2017
38
Amlodipine-induced gingival enlargement. ( 29026579 )
2017
39
Efficacy of azithromycin and metronidazole combined therapy on rats' gingival overgrowth induced by cyclosporine-A: An experimental animal study. ( 27761387 )
2016
40
Gingival Crevicular Fluid and Plasma Levels of Transglutaminase-2 and Oxidative Stress Markers in Cylosporin A-Induced Gingival Overgrowth. ( 27468796 )
2016
41
In vivo association of immunophenotyped macrophages expressing CD163 with PDGF-B in gingival overgrowth-induced by three different categories of medications. ( 26937363 )
2016
42
Biological roles of KGF, CTGF and TGF-I^ in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study. ( 26894526 )
2016
43
Local cause of gingival overgrowth. Clinical and histological study. ( 27516015 )
2016
44
Upregulation of Slug expression by cyclosporine A contributes to the pathogenesis of gingival overgrowth. ( 27287534 )
2016
45
Gingival Overgrowth Leading to the Diagnosis of Familial Tuberous Sclerosis Complex. ( 26885413 )
2016
46
Amlodipine-induced gingival overgrowth in a child after liver transplant. ( 27818959 )
2016
47
A Clinical Evaluation of Gingival Overgrowth in Children on Antiepileptic Drug Therapy. ( 26894172 )
2016
48
Experimental animal model in a histological study of drug-induced gingival overgrowth. ( 28002516 )
2016
49
Loss of epithelial FAM20A in mice causes amelogenesis imperfecta, tooth eruption delay and gingival overgrowth. ( 27281036 )
2016
50
Immunoexpression of interleukin-6 in drug-induced gingival overgrowth patients. ( 27307657 )
2016

Variations for Gingival Overgrowth

ClinVar genetic disease variations for Gingival Overgrowth:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 RET NM_020975.4(RET): c.2753T> C (p.Met918Thr) single nucleotide variant Pathogenic rs74799832 GRCh37 Chromosome 10, 43617416: 43617416
2 RET NM_020975.4(RET): c.2753T> C (p.Met918Thr) single nucleotide variant Pathogenic rs74799832 GRCh38 Chromosome 10, 43121968: 43121968
3 KCNK4 NM_001317090.1(KCNK4): c.515C> A (p.Ala172Glu) single nucleotide variant Pathogenic GRCh38 Chromosome 11, 64297507: 64297507
4 KCNK4 NM_001317090.1(KCNK4): c.515C> A (p.Ala172Glu) single nucleotide variant Pathogenic GRCh37 Chromosome 11, 64064979: 64064979
5 KCNK4 NM_001317090.1(KCNK4): c.730G> C (p.Ala244Pro) single nucleotide variant Pathogenic GRCh37 Chromosome 11, 64065650: 64065650
6 KCNK4 NM_001317090.1(KCNK4): c.730G> C (p.Ala244Pro) single nucleotide variant Pathogenic GRCh38 Chromosome 11, 64298178: 64298178

Copy number variations for Gingival Overgrowth from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 116297 17 64200000 70900000 Copy number Gingival hyperplasia

Expression for Gingival Overgrowth

Search GEO for disease gene expression data for Gingival Overgrowth.

Pathways for Gingival Overgrowth

Pathways related to Gingival Overgrowth according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CD36 CTSB CTSL FGF2 IL1A IL6
2
Show member pathways
13.9 CCN2 FGF2 IL6 ITGA2 MMP2 NUDT6
3
Show member pathways
13.89 CCN2 FGF2 IL1A IL6 ITGA2 NUDT6
4
Show member pathways
13.73 CCN2 FGF2 IL6 ITGA2 MMP1 MMP2
5
Show member pathways
13.59 CCN2 FGF2 IL6 KCNK4 NUDT6 PDGFB
6
Show member pathways
13.58 CCN2 FGF2 IL1A IL6 ITGA2 NUDT6
7
Show member pathways
13.53 CD36 FGF2 ITGA2 MMP2 PDGFB RET
8
Show member pathways
13.44 CCN2 FGF2 IL1A IL6 ITGA2 NUDT6
9
Show member pathways
13.42 CD36 ITGA2 MMP1 MMP2 MMP3 SOS1
10
Show member pathways
13.36 CCN2 FGF2 IL6 NUDT6 PDGFB SOS1
11
Show member pathways
13.34 CD36 ITGA2 MMP1 PDGFB SOS1 TGFB1
12
Show member pathways
13.33 CCN2 FGF2 IL1A IL6 NUDT6 PDGFB
13
Show member pathways
13.31 CCN2 FGF2 IL6 NUDT6 PDGFB SOS1
14
Show member pathways
13.26 CD36 FGF2 IL1A IL6 MMP1 MMP2
15
Show member pathways
13.1 CCN2 FGF2 IL6 ITGA2 NUDT6 PDGFB
16
Show member pathways
13.08 CCN2 FGF2 IL6 NUDT6 PDGFB SOS1
17
Show member pathways
12.92 CTSB CTSL IL1A IL6 SOS1 TGFB1
18
Show member pathways
12.88 MMP3 PDGFB RET SOS1 TGFB1
19 12.83 FGF2 IL6 ITGA2 MMP1 MMP2 PDGFB
20
Show member pathways
12.79 FGF2 IL6 MMP2 PDGFB SOS1
21 12.79 FGF2 IL1A PDGFB SOS1 TGFB1
22
Show member pathways
12.75 CCN2 FGF2 IL1A IL6 NUDT6 PDGFB
23
Show member pathways
12.64 FGF2 IL6 MMP2 PDGFB SOS1 TIMP1
24
Show member pathways
12.44 IL1A IL6 SOS1 TGFB1
25
Show member pathways
12.35 CCN2 FGF2 IL6 ITGA2 NUDT6 PDGFB
26
Show member pathways
12.35 CTSB CTSL DCN FGF2 ITGA2 MMP1
27 12.34 CTSL DCN FGF2 ITGA2 MMP2 SOS1
28
Show member pathways
12.33 FGF2 IL1A IL6 SOS1
29
Show member pathways
12.29 CCN2 FGF2 IL1A IL6 NUDT6 PDGFB
30
Show member pathways
12.28 MMP1 MMP3 SOS1 TIMP1
31
Show member pathways
12.27 IL1A ITGA2 MMP1 MMP2 MMP3 SOS1
32 12.24 IL6 MMP1 MMP2 SOS1 TGFB1
33
Show member pathways
12.16 IL6 MMP2 SOS1 TGFB1
34 12.13 CTSL IL1A MMP2 PDGFB
35 12.11 FGF2 IL6 PDGFB TGFB1
36 12.11 ITGA2 MMP1 SOS1 TGFB1
37
Show member pathways
12.11 CD36 CTSB CTSL IL6 MMP2 MMP3
38
Show member pathways
11.99 CCN2 FGF2 IL1A IL6 NUDT6 PDGFB
39 11.96 IL1A IL6 MMP2 TGFB1
40
Show member pathways
11.96 MMP1 MMP2 MMP3 TIMP1
41 11.94 CD36 IL1A IL6 ITGA2
42 11.91 FGF2 MMP2 MMP3 TGFB1 TIMP1
43 11.86 CTSL IL1A IL6 MMP1 MMP3 TGFB1
44
Show member pathways
11.84 IL6 SOS1 TIMP1
45 11.8 CD36 IL6 MMP3 TGFB1
46
Show member pathways
11.76 FGF2 ITGA2 PDGFB TGFB1
47
Show member pathways
11.74 IL1A IL6 MMP1 MMP2 MMP3
48 11.71 MMP1 MMP2 MMP3 TIMP1
49 11.65 DCN ITGA2 TGFB1
50 11.63 IL6 MMP1 SOS1 TGFB1

GO Terms for Gingival Overgrowth

Cellular components related to Gingival Overgrowth according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 CCN2 CTSB CTSL DCN FAM20A FGF2
2 extracellular matrix GO:0031012 9.7 CCN2 DCN MMP1 MMP2 MMP3 TGFB1
3 collagen-containing extracellular matrix GO:0062023 9.65 CTSB DCN MMP2 PDGFB TGFB1
4 Golgi lumen GO:0005796 9.58 DCN PDGFB TGFB1
5 platelet alpha granule lumen GO:0031093 9.54 PDGFB TGFB1 TIMP1
6 extracellular space GO:0005615 9.47 CCN2 CD36 CTSB CTSL DCN FAM20A
7 endolysosome lumen GO:0036021 9.32 CTSB CTSL

Biological processes related to Gingival Overgrowth according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.98 CCN2 FGF2 IL1A IL6 PDGFB TGFB1
2 negative regulation of gene expression GO:0010629 9.95 CCN2 CD36 PDGFB TGFB1
3 cellular protein metabolic process GO:0044267 9.93 IL6 MMP1 MMP2 TIMP1
4 extracellular matrix organization GO:0030198 9.92 DCN FGF2 ITGA2 PDGFB
5 positive regulation of gene expression GO:0010628 9.91 CCN2 CD36 IL1A IL6 PDGFB RET
6 aging GO:0007568 9.9 CCN2 DCN TGFB1 TIMP1
7 response to hypoxia GO:0001666 9.89 ITGA2 MMP2 MMP3 TGFB1
8 MAPK cascade GO:0000165 9.89 FGF2 PDGFB RET SOS1 TGFB1
9 positive regulation of protein kinase B signaling GO:0051897 9.88 FGF2 PDGFB RET TGFB1
10 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.88 CCN2 CD36 FGF2 PDGFB RET TGFB1
11 positive regulation of MAPK cascade GO:0043410 9.86 CD36 IL6 PDGFB RET
12 platelet degranulation GO:0002576 9.84 CD36 PDGFB TGFB1 TIMP1
13 cellular response to mechanical stimulus GO:0071260 9.82 ITGA2 KCNK4 TGFB1
14 response to wounding GO:0009611 9.81 CCN2 PDGFB TGFB1
15 positive regulation of MAP kinase activity GO:0043406 9.79 FGF2 PDGFB TGFB1
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.78 IL6 ITGA2 PDGFB
17 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.78 CD36 IL6 PDGFB TGFB1
18 positive regulation of cell division GO:0051781 9.76 FGF2 IL1A PDGFB TGFB1
19 positive regulation of blood vessel endothelial cell migration GO:0043536 9.75 FGF2 PDGFB TGFB1
20 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.74 FGF2 MMP2 PDGFB
21 wound healing GO:0042060 9.72 DCN FGF2 ITGA2 TGFB1 TIMP1
22 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.7 FGF2 PDGFB TGFB1
23 positive regulation of collagen biosynthetic process GO:0032967 9.69 CCN2 ITGA2 TGFB1
24 hyaluronan catabolic process GO:0030214 9.67 FGF2 TGFB1
25 positive regulation of protein oligomerization GO:0032461 9.67 MMP1 MMP3
26 positive regulation of DNA biosynthetic process GO:2000573 9.66 FGF2 PDGFB
27 cellular response to thyroid hormone stimulus GO:0097067 9.66 CTSB CTSL
28 positive regulation of chemotaxis GO:0050921 9.65 PDGFB TGFB1
29 cell activation GO:0001775 9.65 TGFB1 TIMP1
30 positive regulation of phagocytosis, engulfment GO:0060100 9.64 CD36 ITGA2
31 paracrine signaling GO:0038001 9.61 FGF2 PDGFB
32 extracellular matrix disassembly GO:0022617 9.55 CTSL MMP1 MMP2 MMP3 TIMP1
33 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.43 IL1A TGFB1 TIMP1
34 collagen catabolic process GO:0030574 9.35 CTSB CTSL MMP1 MMP2 MMP3
35 cytokine-mediated signaling pathway GO:0019221 9.32 CD36 FGF2 IL1A IL6 MMP1 MMP2
36 positive regulation of cell proliferation GO:0008284 10.02 CCN2 FGF2 IL6 PDGFB TGFB1 TIMP1

Molecular functions related to Gingival Overgrowth according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.83 CTSB CTSL MMP1 MMP2 MMP3
2 serine-type endopeptidase activity GO:0004252 9.65 CTSB CTSL MMP1 MMP2 MMP3
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.62 FGF2 PDGFB RET SOS1
4 cytokine activity GO:0005125 9.55 FGF2 IL1A IL6 TGFB1 TIMP1
5 growth factor activity GO:0008083 9.43 CCN2 FGF2 IL6 PDGFB TGFB1 TIMP1
6 proteoglycan binding GO:0043394 9.4 CTSB CTSL
7 collagen binding GO:0005518 9.02 CTSB CTSL DCN ITGA2 PDGFB
8 protein binding GO:0005515 10.3 CCN2 CD36 CTSB CTSL DCN FAM20A

Sources for Gingival Overgrowth

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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