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MCID: GNG013
MIFTS: 59

Gingivitis

Categories: Gastrointestinal diseases, Oral diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Gingivitis

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MalaCards integrated aliases for Gingivitis:

Name: Gingivitis 12 74 29 54 43 15 71
Chronic Gingivitis 12 54 71 32
Acute Gingivitis 12 71 32

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:3087
ICD9CM 34 523.0 523.1
MeSH 43 D005891
UMLS 71 C0008684 C0017574 C0155937
Sources

Summaries for Gingivitis

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MalaCards based summary : Gingivitis, also known as chronic gingivitis, is related to gingival overgrowth and periodontitis, chronic, and has symptoms including signs and symptoms, digestive, tenderness of gums and denture irritation. An important gene associated with Gingivitis is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Tea tree oil and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and testes, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 74 Gingivitis is a non-destructive disease that causes inflammation of the gums. The most common form of... more...

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Related Diseases for Gingivitis

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Diseases related to Gingivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1229)
# Related Disease Score Top Affiliating Genes
1 gingival overgrowth 34.6 TNF MMP8 MMP1 IL6 IL1A CXCL8
2 periodontitis, chronic 33.6 MMP8 MMP1 IL6 IL1B
3 periodontitis, aggressive, 1 32.8 MMP8 MMP1 LTF IL1A
4 cyclic neutropenia 32.7 TNF IL1B ELANE CXCL8
5 gingival disease 32.7 TNF TLR2 MMP9 MMP8 MMP1 IL6
6 orofacial granulomatosis 32.6 TNF IL4 IL10
7 periapical periodontitis 31.5 TNF TLR2 MMP9 MMP8 IL6 IL1B
8 oral lichen planus 31.5 MMP1 IL1A ICAM1
9 periodontitis 31.5 TNF TLR2 MMP9 MMP8 MMP1 IL6
10 osteonecrosis 31.0 TNF MMP8 IL10
11 glossitis 30.9 TNF IL6 IL1B
12 root resorption 30.9 MMP9 IL6 IL4 IL1B IL1A
13 sarcoidosis 1 30.8 TNF IL1B IL1A ICAM1
14 ligneous conjunctivitis 30.8 PLAT ELANE
15 lichen planus 30.8 TNF IL6 IL4 IL10 ICAM1 DEFB4A
16 stomatitis 30.7 TNF TLR2 IL6 IL4 IL1B IL10
17 aggressive periodontitis 30.7 TNF TLR2 MMP9 MMP8 MMP1 IL6
18 leukemia, acute monocytic 30.7 TNF IL6 CXCL8
19 purpura 30.7 TNF IL6 IL4 IL10
20 acquired immunodeficiency syndrome 30.7 TNF IL6 IL1B IL10 ICAM1
21 granulomatosis with polyangiitis 30.6 TNF TLR2 ELANE CTSG
22 graft-versus-host disease 30.6 TNF IL6 IL1B IL1A IL10
23 infective endocarditis 30.6 TNF TLR2 IL6
24 cytomegalovirus infection 30.6 TNF IL6 IL1B CXCL8
25 oral candidiasis 30.6 LTF IL1A DEFB4A CXCL8
26 allergic hypersensitivity disease 30.6 TNF TLR2 IL4 IL10 ICAM1 CXCL8
27 monocytic leukemia 30.6 TNF IL6 IL1B CXCL8
28 chronic graft versus host disease 30.6 IL1A IL10
29 plague 30.6 TNF TLR2 IL6 IL10
30 exanthem 30.5 TNF IL6 IL10 CXCL8
31 pharyngitis 30.5 TNF IL6 IL1B CXCL8
32 pulpitis 30.5 TNF MMP1 IL6 IL1B IL1A CXCL8
33 elephantiasis 30.5 IL4 IL10 ELANE
34 cerebral palsy 30.5 TNF MMP8 IL6 IL1B IL10 CXCL8
35 post-transplant lymphoproliferative disease 30.4 TNF IL6 IL1A IL10
36 chlamydia pneumonia 30.4 TNF TLR2 IL6 IL10 CXCL8
37 mycobacterium tuberculosis 1 30.4 TNF TLR2 IL4 IL10
38 haemophilus influenzae 30.4 TNF TLR2 LTF CXCL8
39 liver disease 30.3 TNF IL6 IL1B IL1A CXCL8
40 spinal cord injury 30.3 TNF MMP9 IL6 CXCL8
41 cellulitis 30.3 TNF IL6 IL10 DEFB4A
42 arteriovenous malformation 30.3 TNF MMP9 IL6
43 mixed connective tissue disease 30.3 TNF IL6 IL10
44 burning mouth syndrome 30.3 TNF IL6 IL1B
45 measles 30.3 TNF TLR2 IL6 IL1B
46 crohn's colitis 30.3 TNF IL1B CXCL8
47 aortic aneurysm, familial abdominal, 1 30.2 MMP9 MMP8 MMP1 IL6 ELANE
48 pulmonary tuberculosis 30.2 TNF TLR2 IL6 IL4 IL10
49 vasculitis 30.2 TNF LTF IL6 ICAM1 ELANE CTSG
50 chickenpox 30.2 TNF IL6 IL4 IL10

Comorbidity relations with Gingivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Dental Caries

Graphical network of the top 20 diseases related to Gingivitis:



Diseases related to Gingivitis
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Symptoms & Phenotypes for Gingivitis

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UMLS symptoms related to Gingivitis:


signs and symptoms, digestive, tenderness of gums, denture irritation

GenomeRNAi Phenotypes related to Gingivitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 CXCL8 ICAM1 IL10 IL1A IL1B SERPINB2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 CXCL8 ICAM1 IL10 IL1A IL1B SERPINB2

MGI Mouse Phenotypes related to Gingivitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 ELANE GUSB ICAM1 IL10 IL1A IL1B
2 hematopoietic system MP:0005397 10.33 CTSG ELANE GUSB ICAM1 IL10 IL1A
3 immune system MP:0005387 10.31 CTSG ELANE ICAM1 IL10 IL1A IL1B
4 integument MP:0010771 10.11 GUSB ICAM1 IL10 IL1A IL1B IL4
5 neoplasm MP:0002006 10.1 CTSG ELANE ICAM1 IL10 IL1A IL1B
6 digestive/alimentary MP:0005381 10.08 ICAM1 IL10 IL4 IL6 MMP9 PLAT
7 muscle MP:0005369 9.92 ICAM1 IL10 IL6 MMP9 PLAT SERPINB2
8 respiratory system MP:0005388 9.76 IL10 IL4 IL6 LPO MMP9 PLAT
9 skeleton MP:0005390 9.65 GUSB IL10 IL1B IL4 IL6 MMP9
10 vision/eye MP:0005391 9.28 ICAM1 IL10 IL4 IL6 LPO MMP9
Sources

Drugs & Therapeutics for Gingivitis

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Drugs for Gingivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 227)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tea tree oil Approved Phase 4
2
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Racepinephrine Approved Phase 4 329-65-7 838
5
Ethanol Approved Phase 4 64-17-5 702
6
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
7
Cetylpyridinium Approved Phase 4 7773-52-6
8
Thymol Approved Phase 4 89-83-8 6989
9
Hexetidine Approved, Investigational Phase 4 141-94-6
10
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
11
Menthol Approved Phase 4 2216-51-5 16666
12
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
13
Metronidazole Approved Phase 4 443-48-1 4173
14
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
15
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
16
Epicatechin Investigational Phase 4 490-46-0, 35323-91-2 72276
17 Tea Tree Phase 4
18 Photosensitizing Agents Phase 4
19 Vitamins Phase 4
20 Calcium, Dietary Phase 4
21 Hormones Phase 4
22 Epinephryl borate Phase 4
23 Anesthetics Phase 4
24 Protective Agents Phase 4
25 Cariostatic Agents Phase 4
26 Hypolipidemic Agents Phase 4
27 Fluorophosphate Phase 4
28 Lipid Regulating Agents Phase 4
29 Antimetabolites Phase 4
30 Pharmaceutical Solutions Phase 4
31 Antiprotozoal Agents Phase 4
32 Acidophilus Phase 4
33
Tin Phase 4 7440-31-5
34 Tin Fluorides Phase 4
35 Antioxidants Phase 4
36 Aloe Phase 4
37 Caseins Phase 4
38 Salicylates Phase 4
39 Immunologic Factors Phase 4
40 Adjuvants, Immunologic Phase 4
41 Viscosupplements Phase 4
42 Chelating Agents Phase 4
43 Anesthetics, Local Phase 4
44 Antiparasitic Agents Phase 4
45
Procyanidin Phase 4 4852-22-6 147299
46 Proanthocyanidin Phase 4
47 Anthocyanidin Phase 4
48 Anti-Infective Agents, Local Phase 4
49 Chlorhexidine gluconate Phase 4
50 Disinfectants Phase 4

Interventional clinical trials:

(show top 50) (show all 350)
# Name Status NCT ID Phase Drugs
1 Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. A Randomized Clinical Trial Unknown status NCT02946801 Phase 4 Essential oils;Essential oils without alcohol;Sterile water
2 Randomized Trial to Evaluate the Efficacy of Two Different Toothbrushes on Plaque Control Unknown status NCT03099551 Phase 4
3 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
4 Mouthwashes as Positive Modulators of Periodontal Response During Orthodontic Treatment: a 6-month Randomized Placebo Controlled Clinical Trial Unknown status NCT03179735 Phase 4 Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
5 Comparing the Effect of 0,06 % -, 0,12 % and 0,2 % Chlorhexidine on Plaque, Bleeding and Side Effects in an Experimental Gingivitis Model. A Parallel, Double Masked, Randomized, Placebo-controlled Clinical Trial Unknown status NCT02911766 Phase 4 Chlorhexidine 0.2% Mouthrinse;Chlorhexidine 0.12% mouthrinse;Chlorhexidine 0.06% mouthrinse
6 Photodynamic Disinfection in Combination With Scaling and Root Planing in the Treatment of Chronic Periodontitis Unknown status NCT00297531 Phase 4
7 Clinical Outcomes Following Non-Surgical Treatment of Chronic Periodontitis, Using Scaling and Root Planing (SRP) in Conjunction With PerioWave, Compared to SRP Alone Unknown status NCT00296881 Phase 4
8 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
9 Methodology of Application and Immediate Effect of the Essential Oils and 0.2% Chlorhexidine on Oral Biofilm: Immersion Versus Mouthwash. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
10 Anti-plaque Effect of 0.12% Chlorhexidine Gluconate Rinsing and Nanoparticle Solution of 0.3% Melaleuca Alternifolia: A Randomized Crossover Clinical Trial Unknown status NCT02695901 Phase 4 Chlorhexidine gluconate 0.12% (PerioGard®);Nanoparticle solution of M. alternifolia oil (0.3%).
11 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). A Randomized Double Blind Interventional Study. Unknown status NCT01778699 Phase 4
12 Estimation of Interleukin-21 Levels in Gingival Crevicular Fluid in Patients With Periodontal Health and Disease Following Non-surgical Periodontal Therapy: A Clinico-biochemical Study Completed NCT02861937 Phase 4
13 Compare Anti-inflammatory Dentifrices Completed NCT00762528 Phase 4 Triclosan/Copolymer/fluoride toothpaste;Sodium monofluorophosphate toothpaste
14 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00855933 Phase 4
15 A 3-Month Clinical Study to Assess the Plaque and Gingivitis Effects of a Stannous Fluoride Dentifrice Completed NCT03936569 Phase 4 Marketed Toothpaste;Marketed Cavity Protection Toothpaste
16 A 3-Month Clinical Study to Assess the Effects of a Stannous Fluoride Dentifrice on Plaque and Gingivitis Completed NCT03936556 Phase 4 Marketed toothpaste;Marketed Cavity Protection Toothpaste
17 Evaluate Inflammation Caused by Gingivitis in Adults Completed NCT00941668 Phase 4 Triclosan/Copolymer/fluoride toothpaste;sodium monofluorophosphate toothpaste
18 "The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients. Completed NCT02154594 Phase 4 Acacia catechu;Chlorhexidine gluconate
19 Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth: a Randomised Clinical Trial. Completed NCT02124655 Phase 4 Essential oils;0.2% chlorhexidine;Sterile water
20 Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste in Reducing Plaque and Gingivitis - a Three Month Study Completed NCT04033575 Phase 4 Colgate Total SF;Colgate Cavity Protection toothpaste
21 Clinical Study to Evaluate the Efficacy of Chlorhexidine Mouthwashes Completed NCT01751178 Phase 4 Chlorhexidine Digluconate Mouthwash with Alcohol;Chlorhexidine Digluconate Mouthwash without Alcohol
22 Effect of an Amine Fluoride/Stannous Fluoride Containing Mouthrinse on Gingival Inflammation,Plaque Development, Discoloration and Bacterial Plaque Composition Over Six Months. Completed NCT01317446 Phase 4 amine fluoride/stannous fluoride
23 The Clinical Investigation of Colgate Total Toothpaste as Compared to Parodontax Toothpaste and Colgate Cavity Protection Toothpaste in Controlling Established Plaque and Gingivitis. (A Six Month Study) Completed NCT02080273 Phase 4 Colgate Cavity Protection toothpaste;Colgate Total toothpaste;Parodontax toothpaste
24 Effects of Cetylpyridium Chloride (CPC) Based Chewing Gum Plus Tooth Brushing on Plaque Formation and Gingivitis: a Randomized, Double-Blind, Crossover, Placebo-controlled Clinical Trial Completed NCT03219840 Phase 4 CPC;Placebo
25 Effects Of Chlorhexidine Mouthrinse On Peridontopathogens: A Randomized, Placebo-Controlled Study Completed NCT01213550 Phase 4 Chlorhexidine gluconate;Placebo mouthrinse
26 Clinical Efficacy and Patient Acceptance of Metal and Metal-Free Interdental Brushes: A Controlled Prospective Randomized Study Completed NCT01593540 Phase 4
27 Effects of Two Sugar Substituted Chewing Gums Plus Tooth Brushing on Different Caries and Gingivitis Related Variables: a Double Blind, Randomized Controlled Clinical Trial Completed NCT01578603 Phase 4
28 The Clinical Investigation of Colgate Total Toothpaste as Compared to Crest Pro-Health Toothpaste and Crest Pro-Health Mouthwash, and Crest Cavity Protection Toothpaste and Crest Fluoride Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Completed NCT02360995 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride toothpaste;Fluoride Mouthwash;cetylpyridinium chloride Mouthwash
29 Clinical Efficacy in Reducing Established Dental Plaque and Gingivitis of a Toothpaste Containing 0.3% Triclosan, 2% Copolymer / Sodium Fluoride and a Manual Toothbrush as Compared to an Oral Hygiene Multi-component Regimen Encompassing the Use of a Manual Toothbrush, a Toothpaste Containing Stannous Fluoride / Sodium Hexametaphosphate and a Mouthwash Containing 0.07% Cetylpyridinium Chloride Completed NCT02366689 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride only toothpaste;Cetylpyridinium chloride mouthwash;Fluoride only mouthwash
30 Impact of Oral Hygiene Gels on Peri-implant Mucositis Completed NCT03243591 Phase 4
31 Randomized, Examiner Blind, Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After 3 Weeks Use Completed NCT04050722 Phase 4 Sensodyne Repair and Protect;Colgate Cavity Protection
32 Influence of Pre-procedural Oral Rinse in the Induced Bacteremia by Periodontal Instrumentation: a Randomized Clinical Trial Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
33 Evaluation of Mechanical-chemical Gingival Therapy in Diabetic, Obese or Diabese Subjects: Quantitative and Qualitative Analysis of Local and General Aspects. Completed NCT02123563 Phase 4
34 Effectiveness of Metronidazole Gel and Mobile Telephone Short- Message Service Reminders on Gingivitis in Orthodontic Patients: A Randomized Controlled Trial Completed NCT03508999 Phase 4 Metronidazole gel
35 Four Weeks Clinical Efficacy of an Ethyl Lauroyl Arginate HCL (LAE) Mouth Rinse: Effect on Gingivitis Completed NCT02065414 Phase 4
36 The Plaque- and Gingivitis Inhibiting Capacity of a Commercially Available Mouthwash Containing Essential Oils and Ethyl Lauroyl Arginate: A Parallel, Split-mouth, Double Blind, Randomized, Placebo-controlled Clinical Study Completed NCT02884817 Phase 4 Experimental: essential oils and ELA
37 Single Blind, Randomized, Active-controlled Comparative Clinical Trial to Evaluate Clinical Efficacy and Safety Following the Application for 4 Weeks of Bio Mineral Toothpaste in Patients With Mild Periodontitis Completed NCT01548469 Phase 4
38 A Multicenter, Randomized, Examiner Blinded Study of Photoactivated Disinfection With Scaling and Root Planing in the Treatment of Chronic Periodontitis Completed NCT00297518 Phase 4
39 Aloe Vera and Chlorhexidine as Preventive Oral Antiseptics Against the Appearance of Traumatic Oral Ulcers in Patients With Fixed Orthodontics: a Randomized Clinical Trial Completed NCT03633292 Phase 4 Antiseptic clorhexidine gel (Lacer, Barcelona, Spain);Master formula of aloe vera gel 80%
40 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With an Oligomeric Proanthocyanidins Nutritional Supplement Completed NCT02515929 Phase 4
41 Interaction Chlorhexidine-fluoride - a 4-day and 6-week Randomised Clinical Mouthrinse Study Completed NCT02935322 Phase 4 0.12 % chlorhexidine + 0.2 % NaF mouthrinse;0.2 % NaF mouthrinse;0.12% chlorhexidine
42 Effect of Emdogain on Wound Healing After Gingival Recession Coverage Using Connective Tissue Graft: A Pilot Study Completed NCT02230787 Phase 4
43 Effect of Probiotic on the Plaque pH. A Randomized Double Blind Interventional Study Completed NCT01601145 Phase 4
44 Minimally Invasive Treatment for Papillae Deficiencies in Esthetic Zone Using Hyaluronic Acid Completed NCT02876276 Phase 4
45 Phase IV Study to Evaluate and Compare the Efficacy of PeriActive Mouthwash to Chlorhexidine 0.12% Rinse With Regards to Managing Post-surgical Inflammation Associated With Dental Implant Surgery Not yet recruiting NCT02987634 Phase 4
46 The Effect of Freeze-Dried Probiotic Sachets Versus Fermented Dairy Product (Yogurt) on Gingival Bleeding on Brushing in Adolescents (12-15) Years Old : A Randomized Clinical Pilot Study Not yet recruiting NCT03640065 Phase 4 freeze-dried probiotic sachets
47 Clinical Evidence Efficacy of a Mouthwash Containing Propolis for the Control of Plaque and Gingivitis: Phase III, Randomized, Double-blind Comparison With Mouthwash Chlorhexidine Base. Unknown status NCT01750801 Phase 3 Propolis;chlorhexidine
48 Comparative Evaluation of Chlorhexidine, Metronidazole and Combination Gels on Gingivitis: A Randomized Clinical Trial Unknown status NCT03142607 Phase 3 Metronidazole gel;Chlorhexidine Gluconate
49 Comparative Efficacy of a Toothpaste That Reduces Plaque and Gingivitis Completed NCT00926328 Phase 3 Triclosan, fluoride;Fluoride
50 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00964860 Phase 3

Search NIH Clinical Center for Gingivitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


carbamide peroxide

Cochrane evidence based reviews: gingivitis

Sources

Genetic Tests for Gingivitis

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Genetic tests related to Gingivitis:

# Genetic test Affiliating Genes
1 Gingivitis 29
Sources

Anatomical Context for Gingivitis

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MalaCards organs/tissues related to Gingivitis:

40
Bone, Heart, Testes, T Cells, Neutrophil, Thyroid, Liver
Sources

Publications for Gingivitis

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Articles related to Gingivitis:

(show top 50) (show all 7330)
# Title Authors PMID Year
1
Changes in gingival crevicular fluid inflammatory mediator levels during the induction and resolution of experimental gingivitis in humans. 54 61
20447255 2010
2
Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods. 54 61
19627514 2010
3
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease. 54 61
18752566 2009
4
Expression and regulation of the NALP3 inflammasome complex in periodontal diseases. 54 61
19664151 2009
5
Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease. 54 61
19656031 2009
6
Up-regulation of the endoplasmic reticulum stress-response in periodontal disease. 54 61
19109937 2009
7
Drop in transforming growth factor-alpha and osteoprotegerin level in gingival crevicular fluid from patients with gingivitis. 54 61
19591043 2009
8
Lactoferrin in Gingival Crevicular Fluid and Peripheral Blood during Experimental Gingivitis. 54 61
19262727 2009
9
Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease. 54 61
18588867 2008
10
The evaluation of cystatin C, IL-1beta, and TNF-alpha levels in total saliva and gingival crevicular fluid from 11- to 16-year-old children. 54 61
18454664 2008
11
Biomarkers of periodontitis in oral fluids. 54 61
18403884 2008
12
Screening for periodontitis in pregnant women with salivary enzymes. 54 61
18226127 2008
13
The relationship between periodontal status and alkaline phosphatase levels in gingival crevicular fluid in men with hypergonadotropic hypogonadism. 54 61
18306472 2008
14
Dental biofilm, gingivitis and interleukin-1 adjacent to approximal sites of a bonded ceramic. 54 61
17941884 2007
15
Differential expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin mRNA in periodontal diseases. 54 61
17559623 2007
16
Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio. 54 61
17355365 2007
17
Levels of metalloproteinase-2 and -9 and tissue inhibitor of matrix metalloproteinase-1 in gingival crevicular fluid of patients with periodontitis, gingivitis, and healthy gingiva. 54 61
17334003 2007
18
The associations between gingival crevice fluid matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and periodontitis in human immunodeficiency virus-positive patients. 54 61
17076772 2006
19
Gingival crevicular fluid matrix metalloproteinase-13 levels and molecular forms in various types of periodontal diseases. 54 61
17054770 2006
20
Interleukin-1beta, interleukin-12 and interleukin-18 levels in gingival fluid and serum of patients with gingivitis and periodontitis. 54 61
16842511 2006
21
Interleukin-1 levels in gingival crevicular fluid adjacent to restorations of calcium aluminate cement and resin composite. 54 61
15842260 2005
22
Plasminogen activator system in smokers and non-smokers with and without periodontal disease. 54 61
15811061 2005
23
Matrix metalloproteinase-1 and -8 in gingival crevicular fluid during orthodontic tooth movement: a pilot study during 1 month of follow-up after fixed appliance activation. 54 61
15817630 2005
24
Secretory function of neutrophilic leukocytes of the patients with periodontal diseases. 54 61
16340274 2005
25
Plasminogen activators and plasminogen activator inhibitors in gingival crevicular fluid of cyclosporin A-treated patients. 54 61
15191592 2004
26
[IL-1beta and PGE2 production in whole blood and gingival fluid in women with periodontitis and preterm low birth weight]. 54 61
15524408 2004
27
Interleukin-11 and IL-17 and the pathogenesis of periodontal disease. 54 61
15025215 2004
28
Effect of smoking on gingival crevicular fluid cytokine profile during experimental gingivitis. 54 61
14761123 2003
29
Salivary cystatin activity and cystatin C in experimental gingivitis in non-smokers. 54 61
14710768 2003
30
Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis. 54 61
12828663 2003
31
Effects of plaque, psychological stress and gender on crevicular Il-1beta and Il-1ra secretion. 54 61
12631182 2003
32
Porphyromonas gingivalis antigen preferentially stimulates T cells to express IL-17 but not receptor activator of NF-kappaB ligand in vitro. 54 61
12588456 2003
33
Crevicular fluid levels of interleukin-1alpha and interleukin-1beta during experimental gingivitis in young and old adults. 54 61
12670080 2002
34
Effect of low-power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts. 54 61
12355572 2002
35
Relation between alkaline phosphatase in gingigval crevicular fluid of implant teeth and the curing result. 54 61
12903766 2001
36
Salivary cystatin activity and cystatin C in natural and experimental gingivitis in smokers and non-smokers. 54 61
11686817 2001
37
Concentration of interleukin-1beta and neutrophil elastase activity in gingival crevicular fluid during experimental gingivitis. 54 61
11350521 2001
38
Matrix metalloproteinases (MMP-8 and -9) and neutrophil elastase in gingival crevicular fluid of cyclosporin-treated patients. 54 61
11327063 2001
39
[Relation between alkaline phosphatase in gingival crevicular fluid of implant and the curing result]. 54 61
12905820 2001
40
Microassay for the detection of elastase activity in the gingival crevice. 54 61
11142664 2001
41
Increasing expression of tissue plasminogen activator and plasminogen activator inhibitor type 2 in dog gingival tissues with progressive inflammation. 54 61
11163592 2001
42
Detection of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 2(PAI-2) in gingival crevicular fluid from healthy, gingivitis and periodontitis patients. 54 61
10743860 2000
43
Relationship of surface epithelium concentrations of IL-1 alpha and IL-1 beta to clinical inflammation during experimental gingivitis. 54 61
10949833 2000
44
Activities of lysozyme and salivary peroxidase in unstimulated whole saliva in relation to plaque and gingivitis scores in healthy young males. 54 61
10803124 1999
45
Activation of neutrophil collagenase in periodontitis. 54 61
10225890 1999
46
Activity and inhibition of elastase in GCF. 54 61
9696251 1998
47
Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease. 54 61
11845441 1998
48
PGE2, IL-1 beta, and TNF-alpha responses in diabetics as modifiers of periodontal disease expression. 54 61
9722689 1998
49
Salivary anti-hsp65 antibodies as a diagnostic marker for gingivitis and a possible link to atherosclerosis. 54 61
9363905 1997
50
Prostaglandin E2 level in gingival crevicular fluid from patients with Down syndrome. 54 61
9176657 1997
Sources

Variations for Gingivitis

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Expression for Gingivitis

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Search GEO for disease gene expression data for Gingivitis.
Sources

Pathways for Gingivitis

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Pathways related to Gingivitis according to GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.05 TNF TLR2 MMP9 MMP8 MMP1 LTF
2
TGF-Beta Pathway 63
Show member pathways
 13.6 TNF IL6 IL4 IL1B IL1A IL10
3
Akt Signaling 63
Show member pathways
 13.48 TNF TLR2 IL6 IL4 IL1B IL1A
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.47 TNF MMP9 MMP1 IL6 IL4 IL1B
5
PAK Pathway 63
Show member pathways
 13.36 TNF IL6 IL4 IL1B IL1A IL10
6
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 13.21 TNF TLR2 MMP9 IL6 IL1B IL10
7
Human cytomegalovirus infection 36
Show member pathways
 13.01 TNF TLR2 IL6 IL1B ICAM1 CXCL8
8
Allograft rejection 1 36
Show member pathways
 12.97 TNF IL6 IL4 IL1B IL1A IL10
9
Measles 36
Show member pathways
 12.94 TNF TLR2 IL6 IL1B IL1A ICAM1
10
Degradation of the extracellular matrix 65
Show member pathways
 12.85 MMP9 MMP8 MMP1 ICAM1 ELANE CTSG
11
NF-KappaB Family Pathway 63
Show member pathways
 12.77 TNF TLR2 IL6 IL1B IL1A
12
T cell receptor signaling pathway 36
Show member pathways
 12.74 TNF TLR2 IL6 IL4 IL1B IL1A
13
Th17 cell differentiation 36
Show member pathways
 12.73 TNF TLR2 IL6 IL4 IL1B IL1A
14
NF-kappaB Signaling 4
12.65 TNF TLR2 IL4 IL1B IL10
15
Folate Metabolism 1
Show member pathways
 12.48 TNF PLAT IL6 IL4 IL1B ICAM1
16
Defensins 65
Show member pathways
 12.45 TLR2 LTF ELANE DEFB4A CTSG
17
Toll Comparative Pathway 63
Show member pathways
 12.42 TNF IL6 IL1B IL1A CXCL8
18
Toxoplasmosis 36
Show member pathways
 12.41 TNF TLR2 IL4 IL1B IL1A IL10
19
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.4 TNF IL6 IL4 IL1B IL1A IL10
20
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.39 TNF IL6 IL10 CXCL8
21
IL-17 Family Signaling Pathways 64
Show member pathways
 12.39 TNF TLR2 MMP9 MMP1 IL6 IL4
22
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.38 TNF TLR2 IL6 IL1A CXCL8
23
Transcriptional misregulation in cancer 36
12.37 PLAT MMP9 IL6 ELANE CXCL8
24
Tuberculosis 36
12.37 TNF TLR2 IL6 IL1B IL1A IL10
25
Pathogenic Escherichia coli infection 36
12.36 TNF IL6 IL1B CXCL8
26
NOD-like receptor signaling pathway 36
12.36 TNF IL6 IL1B DEFB4A CXCL8
27
IL-1 Family Signaling Pathways 64
Show member pathways
 12.35 TNF TLR2 IL6 IL1B IL1A CXCL8
28
Bacterial infections in CF airways 22
Show member pathways
 12.32 TNF TLR2 IL6 IL4 IL1B DEFB4A
29
Colorectal Cancer Metastasis 63
12.31 TNF TLR2 MMP9 MMP1 IL6
30
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.3 TNF IL6 IL1B IL1A IL10 CXCL8
31
C-type lectin receptor signaling pathway 36
Show member pathways
 12.28 TNF IL6 IL1B IL10
32
Fluid shear stress and atherosclerosis 36
12.23 TNF PLAT MMP9 IL1B IL1A ICAM1
33
Th1 Differentiation Pathway 64
Show member pathways
 12.2 TNF TLR2 IL6 IL1B IL10
34
Yersinia infection 36
12.16 TNF IL6 IL1B IL10 CXCL8
35
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 12.14 TNF TLR2 PLAT MMP9 IL6 IL4
36
TNF signaling pathway 36
12.13 TNF MMP9 IL6 IL1B ICAM1
37
Senescence and Autophagy in Cancer 1
12.1 SERPINB2 PLAT IL6 IL1B IL1A CXCL8
38
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.09 TNF IL6 IL4 IL10
39
Hematopoietic cell lineage 36
12.07 TNF IL6 IL4 IL1B IL1A
40
AGE-RAGE signaling pathway in diabetic complications 36
12.07 TNF IL6 IL1B IL1A ICAM1 CXCL8
41
Matrix Metalloproteinases 1
Show member pathways
 12.06 TNF MMP9 MMP8 MMP1 ELANE CTSG
42
Spinal Cord Injury 1
12.05 TNF MMP9 IL6 IL4 IL1B IL1A
43
NF-kappa B signaling pathway 36
12.03 TNF IL1B ICAM1 CXCL8
44
Amoebiasis 36
12.01 TNF TLR2 IL6 IL1B IL10 CXCL8
45
Glucocorticoid receptor regulatory network 1
11.95 MMP1 IL6 IL4 ICAM1 CXCL8
46
Salmonella infection (KEGG) 36
11.92 IL6 IL1B IL1A CXCL8
47
Innate Lymphoid Cell Differentiation Pathways 64
11.92 TNF IL4 IL1B IL10
48
Pertussis 36
11.91 TNF IL6 IL1B IL1A IL10 CXCL8
49
Dendritic Cells Developmental Lineage Pathway 64
11.88 TNF IL6 IL1B IL10
50
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.86 TNF MMP9 IL6 IL4 IL1B IL10
Sources

GO Terms for Gingivitis

About this section

Cellular components related to Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 TNF SERPINB2 PLAT MMP9 MMP8 MMP1
2 cell surface GO:0009986 9.87 TNF TLR2 PLAT LTF ICAM1 ELANE
3 collagen-containing extracellular matrix GO:0062023 9.73 PLAT MMP9 MMP8 ICAM1 ELANE CTSG
4 specific granule lumen GO:0035580 9.58 MMP8 LTF ELANE
5 extracellular space GO:0005615 9.58 TNF SERPINB2 PLAT MMP9 MMP8 LTF
6 secretory granule GO:0030141 9.55 PLAT LTF IL1B ELANE CTSG
7 tertiary granule lumen GO:1904724 9.54 MMP9 MMP8 LTF

Biological processes related to Gingivitis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.27 TNF TLR2 IL6 IL4 IL1B IL1A
2 negative regulation of apoptotic process GO:0043066 10.16 SERPINB2 MMP9 LTF IL6 IL4 IL10
3 proteolysis GO:0006508 10.14 PLAT MMP9 MMP8 MMP1 LTF ELANE
4 negative regulation of cell proliferation GO:0008285 10.1 TLR2 IL6 IL1B IL1A IL10 CXCL8
5 neutrophil degranulation GO:0043312 10.08 TLR2 MMP9 MMP8 LTF GUSB ELANE
6 positive regulation of gene expression GO:0010628 10.05 TNF TLR2 MMP8 IL6 IL4 IL1B
7 cellular protein metabolic process GO:0044267 10.04 MMP1 LTF IL6 CTSG
8 extracellular matrix organization GO:0030198 10.03 TNF MMP9 MMP8 MMP1 ICAM1
9 inflammatory response GO:0006954 10.02 TNF TLR2 IL6 IL1B IL1A IL10
10 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.01 TNF LTF IL1B IL1A
11 leukocyte migration GO:0050900 10 TNF MMP1 IL1B ICAM1 ELANE
12 positive regulation of DNA-binding transcription factor activity GO:0051091 9.96 TNF IL6 IL1B IL10
13 response to lipopolysaccharide GO:0032496 9.93 TLR2 IL1B IL10 ICAM1 ELANE CTSG
14 defense response to Gram-negative bacterium GO:0050829 9.92 LTF IL6 DEFB4A CTSG
15 positive regulation of JNK cascade GO:0046330 9.92 TNF MMP8 IL1B IL1A
16 response to insulin GO:0032868 9.91 TLR2 IL10 ICAM1
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 TNF IL6 IL4
18 defense response to bacterium GO:0042742 9.91 TNF LTF LPO IL10 ELANE DEFB4A
19 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.9 LTF DEFB4A CXCL8
20 response to glucocorticoid GO:0051384 9.9 TNF IL6 IL10
21 positive regulation of T cell proliferation GO:0042102 9.9 IL6 IL4 IL1B
22 positive regulation of smooth muscle cell proliferation GO:0048661 9.89 TNF IL6 ELANE
23 humoral immune response GO:0006959 9.89 TNF LTF IL6
24 defense response to Gram-positive bacterium GO:0050830 9.89 TNF TLR2 IL6 DEFB4A CTSG
25 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.88 TNF MMP9 IL10
26 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 TNF TLR2 MMP8 IL1B
27 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 TNF TLR2 LTF IL6 IL1B ICAM1
28 collagen catabolic process GO:0030574 9.87 MMP9 MMP8 MMP1
29 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.86 TNF IL1B IL1A
30 negative regulation of endothelial cell apoptotic process GO:2000352 9.86 IL4 IL10 ICAM1
31 antimicrobial humoral response GO:0019730 9.86 LTF ELANE DEFB4A CTSG
32 positive regulation of interleukin-6 secretion GO:2000778 9.85 TNF TLR2 IL1B
33 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 TNF TLR2 IL1B
34 immune response GO:0006955 9.85 TNF TLR2 IL6 IL4 IL1B IL1A
35 positive regulation of JAK-STAT cascade GO:0046427 9.83 TNF IL6 IL10
36 positive regulation of cytokine secretion GO:0050715 9.83 TNF IL1A IL10
37 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 TNF MMP8 IL1B ICAM1
38 extracellular matrix disassembly GO:0022617 9.83 MMP9 MMP8 MMP1 ELANE CTSG
39 positive regulation of vascular endothelial growth factor production GO:0010575 9.82 IL6 IL1B IL1A
40 negative regulation of neurogenesis GO:0050768 9.82 TNF IL6 IL1B
41 positive regulation of interleukin-8 production GO:0032757 9.81 TNF TLR2 IL1B
42 positive regulation of chemokine production GO:0032722 9.79 TNF TLR2 IL6
43 positive regulation of glial cell proliferation GO:0060252 9.77 TNF IL6 IL1B
44 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.76 TNF IL1B IL10
45 positive regulation of chemokine biosynthetic process GO:0045080 9.74 TNF IL1B
46 positive regulation of MHC class II biosynthetic process GO:0045348 9.74 IL4 IL10
47 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.74 IL4 IL10
48 response to molecule of bacterial origin GO:0002237 9.74 TLR2 IL10 CXCL8
49 negative regulation of lipid storage GO:0010888 9.73 TNF IL6
50 endothelial cell apoptotic process GO:0072577 9.73 TNF IL10

Molecular functions related to Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.97 PLAT MMP9 MMP8 MMP1 LTF GUSB
2 peptidase activity GO:0008233 9.7 PLAT MMP9 MMP8 MMP1 LTF ELANE
3 serine-type peptidase activity GO:0008236 9.62 PLAT LTF ELANE CTSG
4 endopeptidase activity GO:0004175 9.56 MMP9 MMP8 MMP1 ELANE
5 cytokine activity GO:0005125 9.5 TNF IL6 IL4 IL1B IL1A IL10
6 serine-type endopeptidase activity GO:0004252 9.17 PLAT MMP9 MMP8 MMP1 LTF ELANE
Sources

Sources for Gingivitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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