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MCID: GNG013
MIFTS: 59

Gingivitis

Categories: Gastrointestinal diseases, Oral diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Gingivitis

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MalaCards integrated aliases for Gingivitis:

Name: Gingivitis 12 73 29 54 44 15 70
Chronic Gingivitis 12 54 70 32
Acute Gingivitis 12 70 32

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:3087
ICD9CM 34 523.0 523.1
MeSH 44 D005891
UMLS 70 C0008684 C0017574 C0155937
Sources

Summaries for Gingivitis

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MalaCards based summary : Gingivitis, also known as chronic gingivitis, is related to periodontitis, chronic and cyclic neutropenia, and has symptoms including signs and symptoms, digestive, tenderness of gums and denture irritation. An important gene associated with Gingivitis is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Hexetidine and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include bone, neutrophil and endothelial, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 73 Gingivitis is a non-destructive disease that causes inflammation of the gums. The most common form of... more...

Sources

Related Diseases for Gingivitis

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Diseases related to Gingivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 780)
# Related Disease Score Top Affiliating Genes
1 periodontitis, chronic 32.1 MMP8 MMP1 IL6 IL1B
2 cyclic neutropenia 31.8 TNF IL1B ELANE CXCL8
3 severe congenital neutropenia 31.6 TNF IL1B IL1A ELANE CXCL8 CTSG
4 stomatitis 31.2 TNF IL6 IL1B IL10 CXCL8
5 gingival recession 31.0 TNF MMP8 IL6 IL1B
6 lichen planus 31.0 TNF IL6 IL1B IL10 DEFB4A CXCL8
7 glossitis 30.8 TNF IL6 IL1B
8 bone resorption disease 30.5 TNF IL6 IL1B
9 periodontitis 30.5 TNF TLR2 TIMP1 MMP9 MMP8 MMP1
10 ligneous conjunctivitis 30.5 PLAT ELANE
11 pharyngitis 30.4 TNF IL6 IL1B CXCL8
12 gingival overgrowth 30.4 TNF TIMP1 MMP8 MMP1 IL6 IL1A
13 vasculitis 30.4 TNF LTF IL6 ELANE CTSG
14 granulomatosis with polyangiitis 30.4 TNF TLR2 ELANE CTSG
15 conjunctivitis 30.4 TNF MMP9 IL6 IL10 CXCL8
16 sarcoidosis 1 30.4 TNF IL1B IL1A IL18
17 chickenpox 30.4 TNF IL6 IL10
18 gingival disease 30.4 TNF TLR2 TIMP1 MMP9 MMP8 MMP1
19 type 1 diabetes mellitus 30.4 TNF IL6 IL1B IL18 IL10 CXCL8
20 root resorption 30.3 MMP9 IL6 IL1B IL1A
21 dermatitis herpetiformis 30.3 TNF IL10 CXCL8
22 neutropenia 30.3 TNF IL6 IL1B IL10 ELANE CXCL8
23 acute pericementitis 30.3 IL1B DEFB4A CXCL8
24 acquired immunodeficiency syndrome 30.3 TNF IL6 IL1B IL10
25 gingival fibromatosis 30.2 TIMP1 MMP1 IL6
26 cellulitis 30.2 TNF IL6 DEFB4A
27 plague 30.1 TNF TLR2 IL6 IL1B IL10
28 actinomycosis 30.1 TNF IL6 IL1B IL10
29 mixed connective tissue disease 30.1 TNF IL6 IL10
30 fabry disease 30.1 TNF IL6 IL1B IL10 GUSB
31 exanthem 30.0 TNF IL6 IL1B IL18 IL10 CXCL8
32 iron deficiency anemia 30.0 TNF LTF IL6
33 idiopathic neutropenia 30.0 TNF IL6 IL1B IL1A IL10
34 periodontitis, aggressive, 1 30.0 MMP8 MMP1 LTF IL1A
35 rhinitis 30.0 TNF IL6 IL10 CXCL8
36 atrophic gastritis 29.9 TNF IL6 IL1B IL10 CXCL8
37 myocarditis 29.9 TNF IL6 IL1B IL18 IL10
38 brucellosis 29.9 TNF IL6 IL18 IL10 CXCL8
39 herpes zoster 29.9 TNF TLR2 IL10
40 oral candidiasis 29.9 LTF IL1A DEFB4A CXCL8
41 osteomyelitis 29.9 TNF TLR2 IL6 IL1B IL1A IL10
42 gastritis 29.9 TNF IL6 IL1B IL10 DEFB4A CXCL8
43 myeloma, multiple 29.8 TNF IL6 IL1B IL10 CXCL8
44 uveitis 29.8 TNF IL6 IL1B IL1A IL10 CXCL8
45 allergic disease 29.8 TNF TLR2 IL6 IL1B IL18 IL10
46 proteasome-associated autoinflammatory syndrome 1 29.8 TNF TLR2 MMP9 IL6 IL1B IL1A
47 atherosclerosis susceptibility 29.8 TNF MMP9 IL6 IL1B IL18 CXCL8
48 connective tissue disease 29.8 TNF IL6 IL1B IL1A IL10 CXCL8
49 disease by infectious agent 29.8 TNF TLR2 IL6 IL1B IL18 IL10
50 mycobacterium tuberculosis 1 29.8 TNF TLR2 IL18 IL10

Comorbidity relations with Gingivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Dental Caries

Graphical network of the top 20 diseases related to Gingivitis:



Diseases related to Gingivitis
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Symptoms & Phenotypes for Gingivitis

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UMLS symptoms related to Gingivitis:


signs and symptoms, digestive; tenderness of gums; denture irritation

GenomeRNAi Phenotypes related to Gingivitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.44 CXCL8 IL10 IL18 IL1A IL1B SERPINB2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.44 CXCL8 IL10 IL18 IL1B SERPINB2 TNF

MGI Mouse Phenotypes related to Gingivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.3 ELANE GUSB IL10 IL18 IL1A IL1B
2 hematopoietic system MP:0005397 10.28 CTSG ELANE GUSB IL10 IL18 IL1A
3 immune system MP:0005387 10.22 CTSG ELANE IL10 IL18 IL1A IL1B
4 cardiovascular system MP:0005385 10.17 IL10 IL18 IL1A IL1B IL6 MMP8
5 integument MP:0010771 10 ELANE GUSB IL10 IL18 IL1A IL1B
6 neoplasm MP:0002006 9.8 CTSG ELANE IL10 IL1A IL1B IL6
7 muscle MP:0005369 9.76 IL10 IL18 IL6 MMP9 PLAT SERPINB2
8 respiratory system MP:0005388 9.23 IL10 IL6 LPO MMP9 PLAT TIMP1
Sources

Drugs & Therapeutics for Gingivitis

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Drugs for Gingivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 300)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hexetidine Approved, Investigational Phase 4 141-94-6
2
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
3
sodium fluoride Approved Phase 4 7681-49-4
4
Ethanol Approved Phase 4 64-17-5 702
5
Cetylpyridinium Approved Phase 4 7773-52-6
6
Calcium carbonate Approved, Investigational Phase 4 471-34-1
7
Thymol Approved Phase 4 89-83-8 6989
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
10
Dimenhydrinate Approved Phase 4 523-87-5 441281
11
Silicon Approved, Investigational Phase 4 7440-21-3 4082203
12
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
13
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
14
Racepinephrine Approved Phase 4 329-65-7 838
15
Zoledronic Acid Approved Phase 4 118072-93-8 68740
16
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
17
Ibuprofen Approved Phase 4 15687-27-1 3672
18
Metronidazole Approved Phase 4 443-48-1 4173
19
Simvastatin Approved Phase 4 79902-63-9 54454
20
Menthol Approved Phase 4 2216-51-5 16666
21
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
22
Catechin Approved, Withdrawn Phase 4 154-23-4 9064
23
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
24
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
25
Acetaminophen Approved Phase 4 103-90-2 1983
26
Turmeric Approved, Experimental, Investigational Phase 4
27
Curcumin Approved, Experimental, Investigational Phase 4 458-37-7 969516
28
Lovastatin Approved, Investigational Phase 4 75330-75-5 53232
29
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
30
Pentetic acid Approved Phase 4 67-43-6
31
Edetic Acid Approved, Vet_approved Phase 4 62-33-9, 60-00-4 6049
32
Iodine Approved, Investigational Phase 4 7553-56-2 807
33
Petrolatum Approved, Investigational Phase 4 8009-03-8
34
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
35
Epicatechin Investigational Phase 4 490-46-0 72276
36
Chlorine dioxide Investigational Phase 4 10049-04-4 24870
37
Triacetin Experimental Phase 4 102-76-1 5541
38 Chlorhexidine gluconate Phase 4
39 Anti-Infective Agents, Local Phase 4
40 Disinfectants Phase 4
41 Anti-Infective Agents Phase 4
42 Listerine Phase 4
43 Acidophilus Phase 4
44 Pharmaceutical Solutions Phase 4
45 Dermatologic Agents Phase 4
46 Caseins Phase 4
47 Chelating Agents Phase 4
48 Calcium, Dietary Phase 4
49 Antimetabolites Phase 4
50 Coagulants Phase 4

Interventional clinical trials:

(show top 50) (show all 808)
# Name Status NCT ID Phase Drugs
1 Randomized Trial to Evaluate the Efficacy of Two Different Toothbrushes on Plaque Control Unknown status NCT03099551 Phase 4
2 Phase IV Study to Evaluate and Compare the Efficacy of PeriActive Mouthwash to Chlorhexidine 0.12% Rinse With Regards to Managing Post-surgical Inflammation Associated With Dental Implant Surgery Unknown status NCT02987634 Phase 4
3 Root Coverage With Connective Tissue Graft Associated With VISTA Versus Tunnel Technique in Miller Class I & II Recession Defects A Randomized Controlled Clinical Trial Unknown status NCT03690635 Phase 4
4 Comparing the Effect of 0,06 % -, 0,12 % and 0,2 % Chlorhexidine on Plaque, Bleeding and Side Effects in an Experimental Gingivitis Model. A Parallel, Double Masked, Randomized, Placebo-controlled Clinical Trial Unknown status NCT02911766 Phase 4 Chlorhexidine 0.2% Mouthrinse;Chlorhexidine 0.12% mouthrinse;Chlorhexidine 0.06% mouthrinse
5 Mouthwashes as Positive Modulators of Periodontal Response During Orthodontic Treatment: a 6-month Randomized Placebo Controlled Clinical Trial Unknown status NCT03179735 Phase 4 Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
6 Methodology of Application and Immediate Effect of the Essential Oils and 0.2% Chlorhexidine on Oral Biofilm: Immersion Versus Mouthwash. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
7 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). A Randomized Double Blind Interventional Study. Unknown status NCT01778699 Phase 4
8 Molecular Evaluation of Inflammatory and Bone Remodeling Markers in Gingival Crevicular Fluid After Selective Alveolar Decortication Unknown status NCT02866929 Phase 4 Mucograft
9 Pinhole Surgical Technique With And Without Use Of Button Application For Treatment Of Multiple Gingival Recessions: A Comparative Controlled Randomized Clinical Trial Unknown status NCT02632968 Phase 4
10 Laser De-epithelialization for Epithelial Exclusion in Root Coverage Procedure: a Clinical Study Unknown status NCT02626117 Phase 4
11 Platelet Rich Fibrin in the Treatment of Palatal Wounds After Epithelialized Free Gingival Grafts Harvesting. A Randomized Clinical Trial Unknown status NCT02438046 Phase 4
12 Clinical Comparison of Alveogyl and Gelatin Sponge in the Management of Pain After Epithelialized Free Gingival Graft Harvesting: A Randomized Clinical Trial Unknown status NCT03402321 Phase 4 Gelatin Sponge Sheet;Alvogyl
13 Effects of Two Sugar Substituted Chewing Gums Plus Tooth Brushing on Different Caries and Gingivitis Related Variables: a Double Blind, Randomized Controlled Clinical Trial Completed NCT01578603 Phase 4
14 Influence of Pre-procedural Oral Rinse in the Induced Bacteremia by Periodontal Instrumentation: a Randomized Clinical Trial Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
15 Palatal Wound Healing Evaluation After Application of Platelet Rich Fibrin Versus 0.2% Hyaluronic Acid Dressings (Randomized Controlled Clinical Trial) Completed NCT04390100 Phase 4 hyaluronic acid (Gengiegel 0.2% oral gel )
16 Effects of Desensitizing Dentifrices on the Reduction of Pain Sensitivity Caused by In-office Dental Whitening: Double Blind Controlled Clinical Study Completed NCT03019224 Phase 4 Hydrogen peroxide
17 Soft and Hard Tissue Stability After Immediate Tooth Replacement With Implant in Fresh Sockets Grafted With Different Soft Tissue Grafts Completed NCT02922075 Phase 4 Post operative medication
18 Xenogenous Collagen Matrix Graft Associated or Not With Enamel Matrix Derivative Proteins in the Treatment of Gingival Recession Class I and II of Miller: Randomized Controlled Clinical Study Completed NCT02456337 Phase 4
19 Effect of Periodontal Therapy and Bisphosphonates on Gingival Crevicular Fluid Levels of Nuclear Factor- κb Ligand (RANKL) and Osteoprotegerin in Postmenopausal Osteoporosis: Results of a 12-Month Study Completed NCT02808988 Phase 4
20 Regenerative Potential of a Collagen Membrane Associated or Not to Bovine Bone in Class II Furcation Defects - A Randomized Clinical Trial. Completed NCT04450849 Phase 4
21 Effectiveness of Metronidazole Gel and Mobile Telephone Short- Message Service Reminders on Gingivitis in Orthodontic Patients: A Randomized Controlled Trial Completed NCT03508999 Phase 4 Metronidazole gel
22 L-PRF Membranes for Increasing the Width of Keratinised Mucosa Around Implants: A Split-mouth, Randomized, Controlled Pilot Clinical Trial Completed NCT03190226 Phase 4
23 Twelve Week Clinical Efficacy of Virtually Supervised Mouth Rinse and Flossing: Effect on Plaque and Gingivitis Completed NCT04750005 Phase 4
24 Pilot Study: Twelve Week Clinical Efficacy of Supervised Mouth Rinse and Flossing: Effect on Plaque and Gingivitis Completed NCT04696536 Phase 4
25 Clinical Efficacy in Reducing Established Dental Plaque and Gingivitis of a Toothpaste Containing 0.3% Triclosan, 2% Copolymer / Sodium Fluoride and a Manual Toothbrush as Compared to an Oral Hygiene Multi-component Regimen Encompassing the Use of a Manual Toothbrush, a Toothpaste Containing Stannous Fluoride / Sodium Hexametaphosphate and a Mouthwash Containing 0.07% Cetylpyridinium Chloride Completed NCT02366689 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride only toothpaste;Cetylpyridinium chloride mouthwash;Fluoride only mouthwash
26 The Clinical Investigation of Colgate Total Toothpaste as Compared to Crest Pro-Health Toothpaste and Crest Pro-Health Mouthwash, and Crest Cavity Protection Toothpaste and Crest Fluoride Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Completed NCT02360995 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride toothpaste;Fluoride Mouthwash;cetylpyridinium chloride Mouthwash
27 Safety and Clinical Efficacy of Mouth Rinses in Type 1 and Type 2 Diabetics: Effect on Oral Soft Tissue, Plaque and Gingivitis Completed NCT04449952 Phase 4
28 A 3-Month Clinical Study to Assess the Effects of a Stannous Fluoride Dentifrice on Plaque and Gingivitis Completed NCT03936556 Phase 4 Marketed toothpaste;Marketed Cavity Protection Toothpaste
29 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With an Oligomeric Proanthocyanidins Nutritional Supplement Completed NCT02515929 Phase 4
30 A 3-Month Clinical Study to Assess the Plaque and Gingivitis Effects of a Stannous Fluoride Dentifrice Completed NCT03936569 Phase 4 Marketed Toothpaste;Marketed Cavity Protection Toothpaste
31 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00855933 Phase 4
32 Four Weeks Clinical Efficacy of an Ethyl Lauroyl Arginate HCL (LAE) Mouth Rinse: Effect on Gingivitis Completed NCT02065414 Phase 4
33 Evaluate Inflammation Caused by Gingivitis in Adults Completed NCT00941668 Phase 4 Triclosan/Copolymer/fluoride toothpaste;sodium monofluorophosphate toothpaste
34 The Plaque- and Gingivitis Inhibiting Capacity of a Commercially Available Mouthwash Containing Essential Oils and Ethyl Lauroyl Arginate: A Parallel, Split-mouth, Double Blind, Randomized, Placebo-controlled Clinical Study Completed NCT02884817 Phase 4 Experimental: essential oils and ELA
35 Effects of Cetylpyridium Chloride (CPC) Based Chewing Gum Plus Tooth Brushing on Plaque Formation and Gingivitis: a Randomized, Double-Blind, Crossover, Placebo-controlled Clinical Trial Completed NCT03219840 Phase 4 Cetylpyridinium Chloride (CPC) 0.09% + Xylitol chewing gum;Xylitol only chewing gum
36 Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste in Reducing Plaque and Gingivitis - a Three Month Study Completed NCT04033575 Phase 4 Colgate Total SF;Colgate Cavity Protection toothpaste
37 The Clinical Investigation of Colgate Total Toothpaste as Compared to Parodontax Toothpaste and Colgate Cavity Protection Toothpaste in Controlling Established Plaque and Gingivitis. (A Six Month Study) Completed NCT02080273 Phase 4 Colgate Cavity Protection toothpaste;Colgate Total toothpaste;Parodontax toothpaste
38 Clinical Study to Evaluate the Efficacy of Chlorhexidine Mouthwashes Completed NCT01751178 Phase 4 Chlorhexidine Digluconate Mouthwash with Alcohol;Chlorhexidine Digluconate Mouthwash without Alcohol
39 Clinical Efficacy and Patient Acceptance of Metal and Metal-Free Interdental Brushes: A Controlled Prospective Randomized Study Completed NCT01593540 Phase 4
40 Randomized, Examiner Blind, Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After 3 Weeks Use Completed NCT04050722 Phase 4 Sensodyne Repair and Protect;Colgate Cavity Protection
41 "The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients. Completed NCT02154594 Phase 4 Acacia catechu;Chlorhexidine gluconate
42 Evaluation of Mechanical-chemical Gingival Therapy in Diabetic, Obese or Diabese Subjects: Quantitative and Qualitative Analysis of Local and General Aspects. Completed NCT02123563 Phase 4
43 Compare Anti-inflammatory Dentifrices Completed NCT00762528 Phase 4 Triclosan/Copolymer/fluoride toothpaste;Sodium monofluorophosphate toothpaste
44 Effect of an Amine Fluoride/Stannous Fluoride Containing Mouthrinse on Gingival Inflammation,Plaque Development, Discoloration and Bacterial Plaque Composition Over Six Months. Completed NCT01317446 Phase 4 amine fluoride/stannous fluoride
45 The Effect of Freeze-Dried Probiotic Sachets Versus Fermented Dairy Product (Yogurt) on Gingival Bleeding on Brushing in Adolescents (12-15) Years Old : A Randomized Clinical Pilot Study Completed NCT03640065 Phase 4 freeze-dried probiotic sachets
46 Effect of Probiotic on the Plaque pH. A Randomized Double Blind Interventional Study Completed NCT01601145 Phase 4
47 Hyaluronic Acid 0.2% Application Enhanced Chronic Periodontitis Treatment in Non-surgical Phase Completed NCT04675385 Phase 4 0.2% hyaluronic acid gel
48 A Randomized Clinical Trial on the Effect of a Chlorine Dioxide Spray on Dental Plaque and Respiratory Pathogens in Institutionalized Elders Completed NCT03533335 Phase 4
49 Effect of Gallium-Aluminum-Arsenide Laser - AsGaAl Low-level Laser Therapy on the Healing of Human Palate Mucosa After Connective Tissue Graft Harvesting: Randomized Clinical Trial Completed NCT02239042 Phase 4
50 Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing on Clinical, Microbiological and Systemic Response Completed NCT02197260 Phase 4 3/d 500 mg metronidazole plus 375 mg amoxicillin for 7 days

Search NIH Clinical Center for Gingivitis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


carbamide peroxide

Cochrane evidence based reviews: gingivitis

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Genetic Tests for Gingivitis

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Genetic tests related to Gingivitis:

# Genetic test Affiliating Genes
1 Gingivitis 29
Sources

Anatomical Context for Gingivitis

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MalaCards organs/tissues related to Gingivitis:

40
Bone, Neutrophil, Endothelial, Heart, Liver, Skin, Kidney
Sources

Publications for Gingivitis

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Articles related to Gingivitis:

(show top 50) (show all 7779)
# Title Authors PMID Year
1
Changes in gingival crevicular fluid inflammatory mediator levels during the induction and resolution of experimental gingivitis in humans. 61 54
20447255 2010
2
Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods. 61 54
19627514 2010
3
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease. 61 54
18752566 2009
4
Expression and regulation of the NALP3 inflammasome complex in periodontal diseases. 61 54
19664151 2009
5
Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease. 61 54
19656031 2009
6
Up-regulation of the endoplasmic reticulum stress-response in periodontal disease. 61 54
19109937 2009
7
Lactoferrin in Gingival Crevicular Fluid and Peripheral Blood during Experimental Gingivitis. 54 61
19262727 2009
8
Drop in transforming growth factor-alpha and osteoprotegerin level in gingival crevicular fluid from patients with gingivitis. 61 54
19591043 2009
9
Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease. 54 61
18588867 2008
10
The evaluation of cystatin C, IL-1beta, and TNF-alpha levels in total saliva and gingival crevicular fluid from 11- to 16-year-old children. 54 61
18454664 2008
11
Biomarkers of periodontitis in oral fluids. 61 54
18403884 2008
12
The relationship between periodontal status and alkaline phosphatase levels in gingival crevicular fluid in men with hypergonadotropic hypogonadism. 61 54
18306472 2008
13
Screening for periodontitis in pregnant women with salivary enzymes. 54 61
18226127 2008
14
Dental biofilm, gingivitis and interleukin-1 adjacent to approximal sites of a bonded ceramic. 54 61
17941884 2007
15
Differential expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin mRNA in periodontal diseases. 61 54
17559623 2007
16
Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio. 61 54
17355365 2007
17
Levels of metalloproteinase-2 and -9 and tissue inhibitor of matrix metalloproteinase-1 in gingival crevicular fluid of patients with periodontitis, gingivitis, and healthy gingiva. 54 61
17334003 2007
18
The associations between gingival crevice fluid matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and periodontitis in human immunodeficiency virus-positive patients. 54 61
17076772 2006
19
Gingival crevicular fluid matrix metalloproteinase-13 levels and molecular forms in various types of periodontal diseases. 54 61
17054770 2006
20
Interleukin-1beta, interleukin-12 and interleukin-18 levels in gingival fluid and serum of patients with gingivitis and periodontitis. 61 54
16842511 2006
21
Interleukin-1 levels in gingival crevicular fluid adjacent to restorations of calcium aluminate cement and resin composite. 61 54
15842260 2005
22
Matrix metalloproteinase-1 and -8 in gingival crevicular fluid during orthodontic tooth movement: a pilot study during 1 month of follow-up after fixed appliance activation. 61 54
15817630 2005
23
Plasminogen activator system in smokers and non-smokers with and without periodontal disease. 54 61
15811061 2005
24
Secretory function of neutrophilic leukocytes of the patients with periodontal diseases. 54 61
16340274 2005
25
Plasminogen activators and plasminogen activator inhibitors in gingival crevicular fluid of cyclosporin A-treated patients. 54 61
15191592 2004
26
[IL-1beta and PGE2 production in whole blood and gingival fluid in women with periodontitis and preterm low birth weight]. 61 54
15524408 2004
27
Interleukin-11 and IL-17 and the pathogenesis of periodontal disease. 61 54
15025215 2004
28
Effect of smoking on gingival crevicular fluid cytokine profile during experimental gingivitis. 54 61
14761123 2003
29
Salivary cystatin activity and cystatin C in experimental gingivitis in non-smokers. 54 61
14710768 2003
30
Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis. 61 54
12828663 2003
31
Effects of plaque, psychological stress and gender on crevicular Il-1beta and Il-1ra secretion. 54 61
12631182 2003
32
Porphyromonas gingivalis antigen preferentially stimulates T cells to express IL-17 but not receptor activator of NF-kappaB ligand in vitro. 54 61
12588456 2003
33
Effect of low-power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts. 61 54
12355572 2002
34
Crevicular fluid levels of interleukin-1alpha and interleukin-1beta during experimental gingivitis in young and old adults. 54 61
12670080 2002
35
Relation between alkaline phosphatase in gingigval crevicular fluid of implant teeth and the curing result. 54 61
12903766 2001
36
Salivary cystatin activity and cystatin C in natural and experimental gingivitis in smokers and non-smokers. 61 54
11686817 2001
37
Concentration of interleukin-1beta and neutrophil elastase activity in gingival crevicular fluid during experimental gingivitis. 61 54
11350521 2001
38
Matrix metalloproteinases (MMP-8 and -9) and neutrophil elastase in gingival crevicular fluid of cyclosporin-treated patients. 61 54
11327063 2001
39
[Relation between alkaline phosphatase in gingival crevicular fluid of implant and the curing result]. 61 54
12905820 2001
40
Increasing expression of tissue plasminogen activator and plasminogen activator inhibitor type 2 in dog gingival tissues with progressive inflammation. 61 54
11163592 2001
41
Microassay for the detection of elastase activity in the gingival crevice. 54 61
11142664 2001
42
Detection of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 2(PAI-2) in gingival crevicular fluid from healthy, gingivitis and periodontitis patients. 61 54
10743860 2000
43
Relationship of surface epithelium concentrations of IL-1 alpha and IL-1 beta to clinical inflammation during experimental gingivitis. 61 54
10949833 2000
44
Activities of lysozyme and salivary peroxidase in unstimulated whole saliva in relation to plaque and gingivitis scores in healthy young males. 61 54
10803124 1999
45
Activation of neutrophil collagenase in periodontitis. 61 54
10225890 1999
46
Activity and inhibition of elastase in GCF. 61 54
9696251 1998
47
PGE2, IL-1 beta, and TNF-alpha responses in diabetics as modifiers of periodontal disease expression. 61 54
9722689 1998
48
Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease. 61 54
11845441 1998
49
Salivary anti-hsp65 antibodies as a diagnostic marker for gingivitis and a possible link to atherosclerosis. 61 54
9363905 1997
50
Prostaglandin E2 level in gingival crevicular fluid from patients with Down syndrome. 54 61
9176657 1997
Sources

Variations for Gingivitis

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Expression for Gingivitis

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Search GEO for disease gene expression data for Gingivitis.
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Pathways for Gingivitis

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Pathways related to Gingivitis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14 TNF TLR2 TIMP1 MMP9 MMP8 MMP1
2
TGF-Beta Pathway 63
Show member pathways
 13.59 TNF TIMP1 IL6 IL1B IL1A IL18
3
Akt Signaling 63
Show member pathways
 13.51 TNF TLR2 TIMP1 IL6 IL1B IL1A
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.46 TNF TIMP1 MMP9 MMP1 IL6 IL1B
5
PAK Pathway 63
Show member pathways
 13.39 TNF TIMP1 IL6 IL1B IL1A IL18
6
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.31 TNF TLR2 MMP9 MMP1 IL6 IL1B
7
Allograft rejection 1 36
Show member pathways
 12.95 TNF IL6 IL1B IL1A IL10 CXCL8
8
Measles 36
Show member pathways
 12.94 TNF TLR2 IL6 IL1B IL1A IL18
9
Degradation of the extracellular matrix 65
Show member pathways
 12.85 TIMP1 MMP9 MMP8 MMP1 ELANE CTSG
10
Salmonella infection (KEGG) 36
Show member pathways
 12.85 TNF TLR2 IL6 IL1B IL18 CXCL8
11
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.84 TNF TLR2 IL6 IL1B IL1A IL18
12
NF-KappaB Family Pathway 63
Show member pathways
 12.81 TNF TLR2 TIMP1 IL6 IL1B IL1A
13
Th17 cell differentiation 36
Show member pathways
 12.72 TNF TLR2 IL6 IL1B IL1A IL18
14
T cell receptor signaling pathway 36
Show member pathways
 12.71 TNF TLR2 IL6 IL1B IL1A IL10
15
Immune response IL-23 signaling pathway 23
Show member pathways
 12.7 TNF TIMP1 IL6 IL1B IL18 IL10
16
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.45 TNF IL6 IL18 IL10 CXCL8
17
Shigellosis 36
12.44 TNF IL1B IL18 CXCL8
18
Defensins 65
Show member pathways
 12.44 TLR2 LTF ELANE DEFB4A CTSG
19
Toll Comparative Pathway 63
Show member pathways
 12.42 TNF IL6 IL1B IL1A CXCL8
20
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.4 TNF TIMP1 IL6 IL1B IL1A IL18
21
Folate Metabolism 1
Show member pathways
 12.38 TNF PLAT IL6 IL1B
22
Transcriptional misregulation in cancer 36
12.38 PLAT MMP9 IL6 ELANE CXCL8
23
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.37 TNF TLR2 IL6 IL1A CXCL8
24
Toxoplasmosis 36
Show member pathways
 12.37 TNF TLR2 IL1B IL1A IL10
25
NOD-like receptor signaling pathway 36
12.37 TNF IL6 IL1B IL18 DEFB4A CXCL8
26
IL-17 Family Signaling Pathways 64
Show member pathways
 12.37 TNF TLR2 MMP9 MMP1 IL6 IL1B
27
Tuberculosis 36
12.36 TNF TLR2 IL6 IL1B IL1A IL18
28
Bacterial infections in CF airways 23
Show member pathways
 12.32 TNF TLR2 IL6 IL1B DEFB4A CXCL8
29
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.31 TNF IL6 IL1B IL1A IL10 CXCL8
30
Colorectal Cancer Metastasis 63
12.3 TNF TLR2 MMP9 MMP1 IL6
31
C-type lectin receptor signaling pathway 36
Show member pathways
 12.28 TNF IL6 IL1B IL10
32
Yersinia infection 36
12.23 TNF IL6 IL1B IL18 IL10 CXCL8
33
Fluid shear stress and atherosclerosis 36
12.22 TNF PLAT MMP9 IL1B IL1A
34
Spinal Cord Injury 1
12.16 TNF MMP9 IL6 IL1B IL1A CXCL8
35
Senescence and Autophagy in Cancer 1
12.09 SERPINB2 PLAT IL6 IL1B IL1A CXCL8
36
TNF signaling pathway 36
12.08 TNF MMP9 IL6 IL1B
37
AGE-RAGE signaling pathway in diabetic complications 36
12.05 TNF IL6 IL1B IL1A CXCL8
38
Hematopoietic cell lineage 36
12.02 TNF IL6 IL1B IL1A
39
Amoebiasis 36
11.96 TNF TLR2 IL6 IL1B IL10 CXCL8
40
Innate Lymphoid Cell Differentiation Pathways 64
11.91 TNF IL1B IL18 IL10
41
Matrix Metalloproteinases 1
Show member pathways
 11.91 TNF TIMP1 MMP9 MMP8 MMP1 ELANE
42
Th1 Differentiation Pathway 64
Show member pathways
 11.89 TNF TLR2 IL6 IL1B IL18 IL10
43
Pertussis 36
11.88 TNF IL6 IL1B IL1A IL10 CXCL8
44
Dendritic Cells Developmental Lineage Pathway 64
11.87 TNF IL6 IL1B IL10
45
Glucocorticoid receptor regulatory network 1
11.84 MMP1 IL6 CXCL8
46
IgA-Producing B Cells in the Intestine 64
11.81 TNF TLR2 IL6 IL10
47
Cell adhesion_ECM remodeling 23
11.8 TIMP1 PLAT MMP9 MMP1 CXCL8
48
Bladder cancer 36 1
11.78 MMP9 MMP1 CXCL8
49
Lung fibrosis 1
11.77 TNF TIMP1 MMP9 IL6 IL1B CXCL8
50
LPA receptor mediated events 1
11.73 MMP9 IL6 CXCL8
Sources

GO Terms for Gingivitis

About this section

Cellular components related to Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 TNF TIMP1 SERPINB2 PLAT MMP9 MMP8
2 cell surface GO:0009986 9.73 TNF TLR2 PLAT LTF ELANE CTSG
3 collagen-containing extracellular matrix GO:0062023 9.72 PLAT MMP9 MMP8 ELANE CTSG
4 extracellular region GO:0005576 9.6 TNF TIMP1 SERPINB2 PLAT MMP9 MMP8
5 specific granule lumen GO:0035580 9.58 MMP8 LTF ELANE
6 tertiary granule lumen GO:1904724 9.54 MMP9 MMP8 LTF
7 secretory granule GO:0030141 9.46 PLAT LTF ELANE CTSG

Biological processes related to Gingivitis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 10.16 PLAT MMP9 MMP8 MMP1 LTF ELANE
2 negative regulation of apoptotic process GO:0043066 10.14 TIMP1 SERPINB2 MMP9 LTF IL6 IL10
3 negative regulation of cell proliferation GO:0008285 10.12 TLR2 IL6 IL1B IL1A IL10 CXCL8
4 neutrophil degranulation GO:0043312 10.1 TLR2 MMP9 MMP8 LTF GUSB ELANE
5 positive regulation of gene expression GO:0010628 10.08 TNF TLR2 MMP8 IL6 IL1B IL1A
6 inflammatory response GO:0006954 10.05 TNF TLR2 IL6 IL1B IL1A IL18
7 cellular protein metabolic process GO:0044267 10.04 TIMP1 MMP1 LTF IL6 CTSG
8 leukocyte migration GO:0050900 10.01 TNF MMP9 MMP1 ELANE
9 response to lipopolysaccharide GO:0032496 10 TLR2 IL1B IL10 ELANE CTSG
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNF TLR2 LTF IL6 IL1B IL18
11 positive regulation of DNA-binding transcription factor activity GO:0051091 9.96 TNF IL6 IL1B IL10
12 defense response to bacterium GO:0042742 9.95 TNF LTF LPO IL10 ELANE DEFB4A
13 positive regulation of inflammatory response GO:0050729 9.94 TNF TLR2 IL1B IL18
14 positive regulation of tumor necrosis factor production GO:0032760 9.93 TLR2 MMP8 IL6 IL1A
15 defense response to Gram-negative bacterium GO:0050829 9.93 LTF IL6 DEFB4A CTSG
16 defense response to Gram-positive bacterium GO:0050830 9.93 TNF TLR2 IL6 DEFB4A CTSG
17 regulation of insulin secretion GO:0050796 9.91 TNF IL6 IL1B
18 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.9 LTF DEFB4A CXCL8
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.9 TNF IL6 IL18
20 cellular response to organic cyclic compound GO:0071407 9.9 TNF IL1B IL18
21 response to glucocorticoid GO:0051384 9.9 TNF IL6 IL10
22 positive regulation of smooth muscle cell proliferation GO:0048661 9.9 TNF IL6 IL18 ELANE
23 positive regulation of interferon-gamma production GO:0032729 9.89 TNF IL1B IL18
24 humoral immune response GO:0006959 9.89 TNF LTF IL6
25 positive regulation of cytokine production GO:0001819 9.89 TNF IL1A IL10
26 antimicrobial humoral response GO:0019730 9.89 LTF ELANE DEFB4A CTSG
27 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.88 TNF MMP9 IL10
28 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 TNF MMP8 IL1B
29 collagen catabolic process GO:0030574 9.87 MMP9 MMP8 MMP1
30 cellular response to lipopolysaccharide GO:0071222 9.87 TNF IL6 IL1B IL1A IL10 CXCL8
31 positive regulation of chemokine production GO:0032722 9.85 TNF TLR2 IL6
32 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.85 TNF IL1B IL1A
33 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 TNF TLR2 MMP8 IL1B IL18
34 positive regulation of interleukin-6 production GO:0032755 9.85 TNF TLR2 MMP8 IL6 IL1B IL1A
35 immune response GO:0006955 9.85 TNF TLR2 IL6 IL1B IL1A IL18
36 positive regulation of JAK-STAT cascade GO:0046427 9.84 TNF IL6 IL10
37 positive regulation of vascular endothelial growth factor production GO:0010575 9.83 IL6 IL1B IL1A
38 negative regulation of neurogenesis GO:0050768 9.83 TNF IL6 IL1B
39 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 TNF TLR2 IL1B IL18
40 positive regulation of interleukin-8 production GO:0032757 9.83 TNF TLR2 IL6 IL1B ELANE
41 positive regulation of glial cell proliferation GO:0060252 9.8 TNF IL6 IL1B
42 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.79 TNF IL1B IL10
43 regulation of neuroinflammatory response GO:0150077 9.76 MMP9 MMP8 IL6
44 cellular response to UV-A GO:0071492 9.75 TIMP1 MMP9 MMP1
45 response to molecule of bacterial origin GO:0002237 9.74 TLR2 IL10 CXCL8
46 negative regulation of chemokine production GO:0032682 9.73 IL6 ELANE
47 regulation of establishment of endothelial barrier GO:1903140 9.73 TNF IL1B
48 negative regulation of lipid storage GO:0010888 9.73 TNF IL6
49 extracellular matrix disassembly GO:0022617 9.73 TIMP1 MMP9 MMP8 MMP1 ELANE CTSG
50 endothelial cell apoptotic process GO:0072577 9.72 TNF IL10

Molecular functions related to Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.97 TLR2 PLAT MMP9 MMP8 MMP1 LTF
2 peptidase activity GO:0008233 9.7 PLAT MMP9 MMP8 MMP1 LTF ELANE
3 serine-type peptidase activity GO:0008236 9.67 PLAT LTF ELANE CTSG
4 endopeptidase activity GO:0004175 9.56 MMP9 MMP8 MMP1 ELANE
5 serine-type endopeptidase activity GO:0004252 9.5 PLAT MMP9 MMP8 MMP1 LTF ELANE
6 cytokine activity GO:0005125 9.23 TNF TIMP1 IL6 IL1B IL1A IL18
Sources

Sources for Gingivitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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