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MCID: GNG013
MIFTS: 63

Gingivitis

Categories: Gastrointestinal diseases, Oral diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Gingivitis

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MalaCards integrated aliases for Gingivitis:

Name: Gingivitis 12 76 29 55 44 15 73
Chronic Gingivitis 12 55 73
Acute Gingivitis 12 73

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Gingivitis

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MalaCards based summary : Gingivitis, also known as chronic gingivitis, is related to gingival disease and periodontitis, aggressive, 1, and has symptoms including signs and symptoms, digestive, tenderness of gums and denture irritation. An important gene associated with Gingivitis is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Chlorhexidine and Hexetidine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and heart, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Gingivitis is a non-destructive disease that occurs around the teeth. The most common form of... more...

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Related Diseases for Gingivitis

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Diseases related to Gingivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 554)
# Related Disease Score Top Affiliating Genes
1 gingival disease 32.6 CD79A ELANE IL1B IL6 MMP8
2 periodontitis, aggressive, 1 32.5 IL1A LTF MMP8
3 periapical periodontitis 32.3 IL1B IL6 MMP8
4 orofacial granulomatosis 31.2 CD79A IL4 TNF
5 periodontitis, chronic 31.0 IL1B IL6 MMP8
6 periodontitis 30.7 CXCL8 IL1A IL1B IL4 IL6 MMP8
7 cytomegalovirus infection 30.5 CXCL8 IL6 TNF
8 esophagitis 30.5 CXCL8 IL1B IL6
9 lichen planus 30.5 DEFB4A IL4 TNF
10 periodontosis 30.4 CD79A CXCL8 ELANE MMP9
11 cerebral palsy 30.4 IL1B IL6 TNF
12 conjunctivitis 30.4 CXCL8 IL4 IL6
13 laryngitis 30.3 IL1B IL6 TNF
14 dengue hemorrhagic fever 30.2 CXCL8 IL6 TNF
15 juvenile rheumatoid arthritis 30.2 IL1B IL6 TNF
16 monocytic leukemia 30.2 CXCL8 IL1B IL6 TNF
17 aggressive periodontitis 30.1 CXCL8 IL1A IL1B IL4 IL6 MMP8
18 paracoccidioidomycosis 30.0 IL4 IL6 TNF
19 prostatitis 30.0 CXCL8 IL1B IL6 TNF
20 leptospirosis 30.0 CXCL8 IL1B IL6 TNF
21 peritonitis 29.9 CXCL8 IL1B IL6 TNF
22 synovitis 29.9 CXCL8 IL1B IL6 TNF
23 vaginitis 29.9 CXCL8 DEFB4A IL1B IL6
24 graft-versus-host disease 29.9 IL1A IL1B IL6 TNF
25 pulpitis 29.7 CXCL8 IL1A IL1B IL6 TNF
26 arthritis 29.7 CXCL8 IL1A IL1B IL6 MMP9 TNF
27 acquired immunodeficiency syndrome 29.7 CD79A IL1B IL6 TNF
28 end stage renal failure 29.6 CD79A IL6 TNF
29 osteomyelitis 29.5 CXCL8 IL1A IL1B IL6 TNF
30 aphthous stomatitis 29.5 IL1B IL4 IL6 TNF
31 pneumonia 29.5 CXCL8 ELANE IL1B IL6 TNF
32 brucellosis 29.4 CXCL8 IL4 IL6 TNF
33 myeloma, multiple 29.3 CD79A CXCL8 IL6 TNF
34 chlamydia 29.3 CD79A CXCL8 IL1B IL6 TNF
35 arteries, anomalies of 29.3 IL1B IL6 MMP9 PLAT TNF
36 root caries 29.1 CD79A LTF
37 multiple sclerosis 28.7 IL1B IL4 IL6 MMP9 TNF
38 periodontal disease 28.5 CD79A CXCL8 DEFB4A ELANE GUSB IL1A
39 wegener granulomatosis 28.5 CTSG CXCL8 ELANE IL6 TNF
40 rheumatoid arthritis 27.8 CD79A CXCL8 IL1A IL1B IL4 IL6
41 tonsillitis 27.6 CD79A CXCL8 IL1A IL1B IL4 IL6
42 systemic lupus erythematosus 27.3 CD79A CTSG IL4 IL6 TNF
43 inflammatory bowel disease 25.0 CTSG CXCL8 DEFB4A ELANE IL1A IL1B
44 gingival overgrowth 12.5
45 gingival recession 12.5
46 gingival fibromatosis 12.4
47 fibromatosis, gingival, 1 12.4
48 hypertrichosis, congenital generalized, with or without gingival hyperplasia 12.4
49 necrotizing ulcerative gingivitis 12.4
50 fibromatosis, gingival, with progressive deafness 12.3

Comorbidity relations with Gingivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Dental Caries

Graphical network of the top 20 diseases related to Gingivitis:



Diseases related to Gingivitis
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Symptoms & Phenotypes for Gingivitis

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UMLS symptoms related to Gingivitis:


signs and symptoms, digestive, tenderness of gums, denture irritation

MGI Mouse Phenotypes related to Gingivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 ELANE GUSB MMP9 IL1A PLAT IL1B
2 homeostasis/metabolism MP:0005376 10.07 LTF ELANE MMP8 GUSB MMP9 IL1A
3 immune system MP:0005387 9.97 ELANE MMP8 MMP9 IL1A PLAT IL1B
4 integument MP:0010771 9.56 GUSB MMP9 IL1A PLAT IL1B IL4
5 neoplasm MP:0002006 9.36 ELANE MMP8 MMP9 IL1A IL1B SERPINB2
Sources

Drugs & Therapeutics for Gingivitis

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Drugs for Gingivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 208)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 55-56-1 9552079 2713
2
Hexetidine Approved, Investigational Phase 4 141-94-6
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 22916-47-8 4189
4 sodium fluoride Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 7681-49-4
5
Tea tree oil Approved Phase 4,Not Applicable
6
Triclosan Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 3380-34-5 5564
7
Ethanol Approved Phase 4,Phase 3,Phase 2,Not Applicable 64-17-5 702
8
Cetylpyridinium Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7773-52-6
9
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
10
Methyl salicylate Approved, Vet_approved Phase 4,Not Applicable 119-36-8 4133
11
Thymol Approved Phase 4,Not Applicable 89-83-8 6989
12
Zinc Approved, Investigational Phase 4,Phase 2,Not Applicable 7440-66-6 23994
13
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 5785 54670067
14
Eucalyptol Approved, Nutraceutical Phase 4,Not Applicable 470-82-6 2758
15 Antifungal Agents Phase 4,Phase 3,Not Applicable
16 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
17 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
18 Cariostatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
19 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2,Not Applicable
20 Dermatologic Agents Phase 4,Phase 3,Phase 2,Not Applicable
21 Disinfectants Phase 4,Phase 3,Phase 2,Not Applicable
22 Fluorides Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
23 Listerine Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
24 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
25 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Anesthetics Phase 4,Phase 1,Not Applicable,Early Phase 1
27 Antimetabolites Phase 4,Phase 3,Phase 2,Not Applicable
28 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Not Applicable
29 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Not Applicable
30 Vitamins Phase 4,Phase 3,Phase 2,Early Phase 1
31 Calcium, Dietary Phase 4,Not Applicable
32 Caseins Phase 4,Not Applicable
33 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
34 Central Nervous System Depressants Phase 4,Not Applicable
35
Tin Phase 4,Phase 3,Not Applicable 7440-31-5
36 Tin Fluorides Phase 4,Phase 3,Not Applicable
37 Antioxidants Phase 4,Phase 3,Phase 1,Not Applicable
38 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
39 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
40 Fluorophosphate Phase 4,Not Applicable
41 Chelating Agents Phase 4,Not Applicable
42 Salicylates Phase 4,Not Applicable
43 Coagulants Phase 4,Phase 3,Not Applicable
44 Fibrin Tissue Adhesive Phase 4
45 Hemostatics Phase 4,Phase 3,Not Applicable
46 Acidophilus Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable
47 Tea Tree Nutraceutical Phase 4,Not Applicable
48 Anthocyanidin Nutraceutical Phase 4
49 Proanthocyanidin Nutraceutical Phase 4
50
Procyanidin Nutraceutical Phase 4 4852-22-6 147299

Interventional clinical trials:

(show top 50) (show all 305)
# Name Status NCT ID Phase Drugs
1 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). Unknown status NCT01778699 Phase 4
2 Methodology Antiseptic Application, Influence on Oral Biofilm. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
3 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
4 Effect of Different Mouthrinses in Plaque Formation Unknown status NCT02695901 Phase 4 Chlorhexidine gluconate 0.12% (PerioGard®);Nanoparticle solution of M. alternifolia oil (0.3%).
5 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
6 The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Completed NCT02360995 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride toothpaste;Fluoride Mouthwash;cetylpyridinium chloride Mouthwash
7 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs Completed NCT02515929 Phase 4
8 Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash) Completed NCT02366689 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride only toothpaste;Cetylpyridinium chloride mouthwash;Fluoride only mouthwash
9 Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste Completed NCT02080273 Phase 4 Colgate Cavitity Protection toothpaste;Colgate Total toothpaste;Parodontax toothpaste
10 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00855933 Phase 4
11 Essential Oil+ELA, Plaque and Gingivitis Completed NCT02884817 Phase 4 Experimental: essential oils and ELA
12 Effects of Two Sugar Substituted Chewing Gums on Caries and Gingivitis Variables Completed NCT01578603 Phase 4
13 Evaluate Inflammation Caused by Gingivitis in Adults Completed NCT00941668 Phase 4 Triclosan/Copolymer/fluoride toothpaste;sodium monofluorophosphate toothpaste
14 A Clinical Trial to Test the Effect of Experimental Mouth Rinse on Gum Disease Completed NCT02065414 Phase 4
15 Effect of Mouthrinsing on Inflammation of the Gums. Completed NCT01317446 Phase 4 amine fluoride/stannous fluoride
16 Estimation of Interleukin-21 Levels in Gingival Crevicular Fluid in Patients With Periodontal Health and Disease Following Non-surgical Periodontal Therapy: A Clinico-biochemical Study Completed NCT02861937 Phase 4
17 Compare Anti-inflammatory Dentifrices Completed NCT00762528 Phase 4 Triclosan/Copolymer/fluoride toothpaste;Sodium monofluorophosphate toothpaste
18 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
19 "The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients. Completed NCT02154594 Phase 4 Acacia catechu;Chlorhexidine gluconate
20 Mechanical-chemical Gingival Therapy in Diabetics and/or Obese Completed NCT02123563 Phase 4
21 An Efficacy Study of Chlorhexidine Mouthwashes Completed NCT01751178 Phase 4 Chlorhexidine Digluconate Mouthwash with Alcohol;Chlorhexidine Digluconate Mouthwash without Alcohol
22 Clinical Examination of Metal Free Interdental Brushes Completed NCT01593540 Phase 4
23 Effect of Probiotic on the Plaque pH. A Randomized Double Blind Interventional Study Completed NCT01601145 Phase 4
24 Effects Of Chlorhexidine Mouthrinse On Peridontopathogens: A Randomized, Placebo-Controlled Study Completed NCT01213550 Phase 4 Chlorhexidine gluconate;Placebo mouthrinse
25 Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. Completed NCT02124655 Phase 4 Essential oils;0.2% chlorhexidine;Sterile water
26 Study to Evaluate Clinical Efficacy and Safety of Bio Mineral Toothpaste in Patients With Mild Periodontitis Completed NCT01548469 Phase 4
27 Evaluation of Photodynamic Treatment FOTOSAN® Efficacy in Periodontology Completed NCT02030470 Phase 4
28 Interaction Between Chlorhexidine and Fluoride Completed NCT02935322 Phase 4 0.12 % chlorhexidine + 0.2 % NaF mouthrinse;0.2 % NaF mouthrinse;0.12% chlorhexidine
29 Effect of Fibrin Sealant on Early Wound Healing Completed NCT01538927 Phase 4 Fibrin Sealant;Suture
30 Treatment of Peri-implantitis Lesions by Using Biomaterial Completed NCT02375750 Phase 4
31 Effectiveness of Metronidazole Gel and Mobile SMS Reminders on Gingivitis in Orthodontic Patients Recruiting NCT03508999 Phase 4 Metronidazole gel
32 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis Active, not recruiting NCT03219840 Phase 4 CPC;Placebo
33 Randomized Trial to Evaluate the Efficacy of Two Different Toothbrushes on Plaque Control Active, not recruiting NCT03099551 Phase 4
34 Impact of Oral Hygiene Gels on Peri-implant Mucositis Active, not recruiting NCT03243591 Phase 4
35 Mouthwashes During Orthodontic Treatment Enrolling by invitation NCT03179735 Phase 4 Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
36 Efficacy of Different Chlorhexidine Concentrations Not yet recruiting NCT02911766 Phase 4 Chlorhexidine 0.2% Mouthrinse;Chlorhexidine 0.12% mouthrinse;Chlorhexidine 0.06% mouthrinse
37 Evaluation and Comparison of Efficacy of PeriActive Mouthwash to Chlorhexidine 0.12% Mouth Rinse Not yet recruiting NCT02987634 Phase 4
38 Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth Not yet recruiting NCT02946801 Phase 4 Essential oils;Essential oils without alcohol;Sterile water
39 Efficacy of a Mouthwash Containing Propolis Unknown status NCT01750801 Phase 3 Propolis;chlorhexidine
40 Comparative Efficacy of a Toothpaste That Reduces Plaque and Gingivitis Completed NCT00926328 Phase 3 Triclosan, fluoride;Fluoride
41 Effects of Antioxidant Dentifrice on Gingivitis Completed NCT02102295 Phase 3 Experimental toothpaste;Control toothpaste
42 The Effect of Mouthrinses Containing Bamboo Salt, Magnolia Bark and Centella Asiatica on Reducing Plaque and Gingivitis Completed NCT03047798 Phase 3 Mouthrinse
43 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00964860 Phase 3
44 The Clinical Efficacy of Three Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Dental Plaque and Gingivitis Completed NCT02193165 Phase 3 triclosan/fluoride toothpaste + cetylpyridinium chloride Mouthwash;stannous fluoride toothpaste + cetylpyridinium chloride Mouthwash;fluoride toothpaste + fluoride Mouthwash
45 The Effect of New Dentifrices Containing Centella Asiatica and Bamboo Salt on Reducing Plaque and Gingivitis Completed NCT02616042 Phase 3
46 Clinical Study to Evaluate the Treatment of Gingivitis of Two Toothpastes Completed NCT00762515 Phase 3 Fluoride;Triclosan;Fluoride
47 Flossing With Chlorhexidine Completed NCT00471783 Phase 3
48 Effectiveness of Black Tea Mouthwash on Plaque Formation Completed NCT02545244 Phase 3 0.12% Chlorhexidine Mouthwash.
49 Effect of Probiotic Lozenge on Gingivitis and Periodontitis Completed NCT02203812 Phase 3 Probiotic Arm;Placebo Arm
50 Comparing the Inter-dental Brush to Dental Floss Completed NCT00743548 Phase 3

Search NIH Clinical Center for Gingivitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: gingivitis

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Genetic Tests for Gingivitis

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Genetic tests related to Gingivitis:

# Genetic test Affiliating Genes
1 Gingivitis 29
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Anatomical Context for Gingivitis

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MalaCards organs/tissues related to Gingivitis:

41
Bone, Testes, Heart, Neutrophil, Monocytes, Endothelial, Liver
Sources

Publications for Gingivitis

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Articles related to Gingivitis:

(show top 50) (show all 3378)
# Title Authors Year
1
Effect of Initial Periodontal Therapy on Salivary Trefoil Factor (TFF3) in otherwise Healthy Patients with Gingivitis and Chronic Periodontitis. ( 29962757 )
2018
2
Treatment of single maxillary gingival recession associated with non-carious cervical lesion: Randomized clinical trial comparing connective tissue graft alone to graft plus partial restoration. ( 29681059 )
2018
3
Is dental plaque the only etiological factor in Amlodipine induced gingival overgrowth? A systematic review of evidence. ( 29930781 )
2018
4
Influence of 3 calcium channel blockers on gingival overgrowth in a population of severe refractory hypertensive patients. ( 29687449 )
2018
5
Treatment of gingival recession using a coronally-advanced flap procedure with or without placental membrane. ( 29607631 )
2018
6
Expression of CD163 in hereditary gingival fibromatosis: A possible association with TGF-I^1. ( 29325232 )
2018
7
Evaluation of periosteum eversion and coronally advanced flap techniques in the treatment of isolated Miller's Class I/II gingival recession: A comparative clinical study. ( 29769769 )
2018
8
Evaluation of the effect of dose-dependent platelet-rich fibrin membrane on treatment of gingival recession: a randomized, controlled clinical trial. ( 29768524 )
2018
9
Coronally advanced flap in conjunction with platelet-rich fibrin-assisted immediate management of residual gingival defect following surgical excision of recurrent pyogenic granuloma in the maxillary esthetic segment. ( 29962710 )
2018
10
Gene expression profiling and bioinformatics analysis of hereditary gingival fibromatosis. ( 29435271 )
2018
11
Desquamative gingivitis: Diagnosis and treatment. ( 29678379 )
2018
12
Comparative Evaluation of Coronally Advanced Flap Using Amniotic Membrane and Platelet-rich Fibrin Membrane in Gingival Recession: An 18-Month Clinical Study. ( 29875559 )
2018
13
Quantitative measures of gingival recession and the influence of gender, race, and attrition. ( 29376198 )
2018
14
Exploring the Gingival Recession Surgical Treatment Modalities: A Literature Review. ( 29731944 )
2018
15
Effect of guava and vitamin C supplementation on experimental gingivitis: A randomized clinical trial. ( 29757462 )
2018
16
Components in Lentinus edodes mushroom with anti-biofilm activity directed against bacteria involved in caries and gingivitis. ( 29882939 )
2018
17
Treatment of gingival recession in 2 surgical stages: free gingival graft plus coronally positioned flap. ( 29303764 )
2018
18
The effects of essential oil mouthrinses with or without alcohol on plaque and gingivitis: a randomized controlled clinical study. ( 29321067 )
2018
19
Reversal of drug-induced gingival overgrowth by UV-mediated apoptosis of gingival fibroblasts - an in vitro study. ( 29427738 )
2018
20
Primary syphilis occurring as an extensive ulceration on the palatal gingival mucosa diagnosed by immunohistochemical staining. ( 29730886 )
2018
21
Coronally advanced flap and connective tissue graft with or without plasma rich in growth factors (PRGF) in treatment of gingival recession. ( 29849966 )
2018
22
Clinical evaluation of Class II and Class III gingival recession defects of maxillary posterior teeth treated with pedicled buccal fat pad: A pilot study. ( 29497442 )
2018
23
Influence of Photobiomodulation Therapy on Gingivitis Induced by Multi-Bracket Appliances: A Split-Mouth Randomized Controlled Trial. ( 29775553 )
2018
24
Effects of Kangfuxin solution on IL-1I^, IL-6, IL-17 and TNF-I+ in gingival crevicular fluid in patients with fixed orthodontic gingivitis. ( 29896253 )
2018
25
Xenogenic collagen matrix or autologous connective tissue graft as adjunct to coronally advanced flaps for coverage of multiple adjacent gingival recession: Randomized trial assessing non-inferiority in root coverage and superiority in oral health-related quality of life. ( 29087001 )
2018
26
Microbiome at sites of gingival recession in children with Hutchinson-Gilford progeria syndrome. ( 29520806 )
2018
27
A novel approach to treat gingival recession and non-caries cervical lesion combined defects: Restoration guided creeping attachment (RGCA) technique. A case report. ( 29662973 )
2018
28
Tobacco smoking decreases clinical symptoms of gingivitis in patients with type 1 diabetes-a cross-sectional study. ( 29757485 )
2018
29
Six-Month Evaluation of a Sodium Bicarbonate-Containing Toothpaste for Reduction of Established Gingivitis: A Randomized USA-Based Clinical Trial. ( 29758155 )
2018
30
Relationship between noncarious cervical lesions, cervical dentin hypersensitivity, gingival recession, and associated risk factors: a cross-sectional study. ( 29940290 )
2018
31
Definitive abutments probably result in minimal decrease in bone loss and buccal gingival recession compared with traditional implants. ( 29150019 )
2018
32
Induction of DNA double-strand breaks in human gingival fibroblasts by eluates from titanium dioxide modified glass ionomer cements. ( 29175161 )
2018
33
High-power diode laser on management of drug-induced gingival overgrowth: Report of two cases and long-term follow-up. ( 29351498 )
2018
34
Fifteen-Year Follow-Up of a Case of Surgical Retreatment of a Single Gingival Recession. ( 29796319 )
2018
35
An 8-Week Clinical Comparison of an Oscillating-Rotating Electric Rechargeable Toothbrush and a Sonic Toothbrush in the Reduction of Gingivitis and Plaque. ( 29758154 )
2018
36
Interleukin-17 and interleukin-23 levels in gingival crevicular fluid of patients with chronic and aggressive periodontitis. ( 29736149 )
2018
37
Prevalence of gingivitis and calculus in 12-year-old Puerto Ricans: a cross-sectional study. ( 29351752 )
2018
38
Gingival Periodontal Disease (PD) Level-Butyric Acid Affects the Systemic Blood and Brain Organ: Insights Into the Systemic Inflammation of Periodontal Disease. ( 29915575 )
2018
39
Desquamative gingivitis: Clinical findings and diseases. ( 29678378 )
2018
40
Effectiveness of two different herbal toothpaste formulations in the reduction of plaque and gingival inflammation in patients with established gingivitis - A randomized controlled trial. ( 29321998 )
2018
41
Effect of scaling and root planing on gingival crevicular fluid cytokine/chemokine levels in smokers with chronic periodontitis: A systematic review. ( 29450974 )
2018
42
Sub-epithelial connective tissue graft for the management of Miller's class I and class II isolated gingival recession defect: A systematic review of the factors influencing the outcome. ( 29424485 )
2018
43
Prevalence of gingival recession after orthodontic tooth movements. ( 29706207 )
2018
44
Gingival complex odontoma: a rare case report with a review of the literature. ( 29515984 )
2018
45
Adjunct Use of Low-Level Laser Therapy on the Treatment of Necrotizing Ulcerative Gingivitis: A Case Report. ( 29399316 )
2018
46
Molecular basis for immunohistochemical and inflammatory changes during progression of gingivitis to periodontitis. ( 29194785 )
2018
47
Gingival melanoacanthoma associated with pseudomelanocytic nests: Expanding the clinicopathological spectrum of a recently described oral lesion. ( 29752741 )
2018
48
Blastic plasmacytoid dendritic cell neoplasm: a rare case of gingival lesion with leukaemic presentation. ( 29735506 )
2018
49
Immunohistochemical Analysis of the Role Connective Tissue Growth Factor in Drug-induced Gingival Overgrowth in Response to Phenytoin, Cyclosporine, and Nifedipine. ( 29629324 )
2018
50
The effect of dietary corn oil and fish oil supplementation in dogs with naturally occurring gingivitis. ( 29908038 )
2018
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Variations for Gingivitis

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Expression for Gingivitis

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Search GEO for disease gene expression data for Gingivitis.
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Pathways for Gingivitis

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Pathways related to Gingivitis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.92 CD79A CTSG CXCL8 DEFB4A ELANE GUSB
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.36 CXCL8 IL1A IL1B IL4 IL6 MMP9
3
PAK Pathway 64
Show member pathways
 13.27 CXCL8 IL1A IL1B IL4 IL6 TNF
4
Allograft rejection 1 37
Show member pathways
 12.9 CXCL8 IL1A IL1B IL4 IL6 TNF
5
Influenza A 37
Show member pathways
 12.82 CXCL8 IL1A IL1B IL4 IL6 TNF
6
IL-2 Pathway 64
Show member pathways
 12.8 CD79A IL1A IL1B IL4 TNF
7
Regulation of IFNA signaling 66
Show member pathways
 12.67 CXCL8 IL1A IL1B IL4 IL6 TNF
8
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.55 CXCL8 IL6 MMP9 TNF
9
NF-kappaB Signaling 4
12.54 CD79A IL1B IL4 TNF
10
Th17 cell differentiation 37
Show member pathways
 12.48 IL1A IL1B IL4 IL6 TNF
11
T cell receptor signaling pathway 37
Show member pathways
 12.46 IL1A IL1B IL4 IL6 TNF
12
Defensins 66
Show member pathways
 12.37 CTSG DEFB4A ELANE LTF
13
Folate Metabolism 1
Show member pathways
 12.37 IL1B IL4 IL6 PLAT TNF
14
Toll Comparative Pathway 64
Show member pathways
 12.32 CXCL8 IL1A IL1B IL6 TNF
15
Transcriptional misregulation in cancer 37
12.31 CXCL8 ELANE IL6 MMP9 PLAT
16
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.28 CXCL8 IL1A IL6 TNF
17
IL-1 Family Signaling Pathways 65
Show member pathways
 12.28 CXCL8 IL1A IL1B IL6 TNF
18
IL-17 Family Signaling Pathways 65
Show member pathways
 12.28 CXCL8 DEFB4A IL1B IL4 IL6 MMP9
19
Toxoplasmosis 37
Show member pathways
 12.27 IL1A IL1B IL4 TNF
20
Tuberculosis 37
12.25 IL1A IL1B IL6 TNF
21
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.23 CXCL8 IL1A IL1B IL6 TNF
22
Bacterial infections in CF airways 22
Show member pathways
 12.19 CXCL8 DEFB4A IL1B IL4 IL6 TNF
23
Fluid shear stress and atherosclerosis 37
12.15 IL1A IL1B MMP9 PLAT TNF
24
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.1 CXCL8 IL1A IL1B IL4 IL6
25
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
12.03 CD79A IL4 IL6 TNF
26
TNF signaling pathway 37
12 IL1B IL6 MMP9 TNF
27
AGE-RAGE signaling pathway in diabetic complications 37
11.96 CXCL8 IL1A IL1B IL6 TNF
28
Matrix Metalloproteinases 1
Show member pathways
 11.95 CTSG ELANE MMP8 MMP9 TNF
29
Senescence and Autophagy in Cancer 1
11.94 CXCL8 IL1A IL1B IL6 PLAT SERPINB2
30
Hematopoietic cell lineage 37
11.93 IL1A IL1B IL4 IL6 TNF
31
Amoebiasis 37
11.92 CTSG CXCL8 IL1B IL6 TNF
32
Salmonella infection (KEGG) 37
11.89 CXCL8 IL1A IL1B IL6
33
NF-kappa B signaling pathway 37
11.88 CXCL8 IL1B TNF
34
Rheumatoid arthritis 37
11.88 CXCL8 IL1A IL1B IL6 TNF
35
Glucocorticoid receptor regulatory network 1
11.81 CXCL8 IL4 IL6
36
Innate Lymphoid Cell Differentiation Pathways 65
11.8 IL1B IL4 TNF
37
Pertussis 37
11.79 CXCL8 IL1A IL1B IL6 TNF
38
Spinal Cord Injury 1
11.78 CXCL8 IL1A IL1B IL4 IL6 MMP9
39
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.77 CXCL8 IL4 TNF
40
Dendritic Cells Developmental Lineage Pathway 65
11.76 IL1B IL6 TNF
41
LPA receptor mediated events 1
11.7 CXCL8 IL6 MMP9
42
Cell adhesion_ECM remodeling 22
11.67 CXCL8 MMP9 PLAT
43
Legionellosis 37
11.66 CXCL8 IL1B IL6 TNF
44
Malaria 37
11.6 CXCL8 IL1B IL6 TNF
45
Lung fibrosis 1
11.6 CXCL8 IL1B IL4 IL6 MMP9 TNF
46
Interleukin-4 and 13 signaling 66
11.56 CXCL8 IL1A IL1B IL4 IL6 MMP9
47
Aryl Hydrocarbon Receptor Pathway 1
11.55 IL1B SERPINB2 TNF
48
Hematopoietic Stem Cell Differentiation 1
11.55 IL1A IL1B IL6
49
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.55 IL1A IL1B IL6 TNF
50
amb2 Integrin signaling 1
11.54 ELANE IL6 MMP9 PLAT TNF
Sources

GO Terms for Gingivitis

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Cellular components related to Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.83 CTSG ELANE LTF PLAT TNF
2 extracellular region GO:0005576 9.83 CTSG CXCL8 DEFB4A ELANE GUSB IL1A
3 extracellular matrix GO:0031012 9.67 CTSG MMP8 MMP9 PLAT
4 azurophil granule lumen GO:0035578 9.58 CTSG ELANE GUSB
5 secretory granule GO:0030141 9.55 CTSG ELANE IL1B LTF PLAT
6 specific granule lumen GO:0035580 9.5 ELANE LTF MMP8
7 extracellular space GO:0005615 9.5 CTSG CXCL8 DEFB4A ELANE GUSB IL1A
8 tertiary granule lumen GO:1904724 9.43 LTF MMP8 MMP9

Biological processes related to Gingivitis according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.99 CXCL8 IL1A IL1B IL6 TNF
2 neutrophil degranulation GO:0043312 9.95 CTSG ELANE GUSB LTF MMP8 MMP9
3 leukocyte migration GO:0050900 9.93 ELANE IL1B MMP9 TNF
4 response to lipopolysaccharide GO:0032496 9.91 CTSG CXCL8 ELANE IL1B
5 regulation of signaling receptor activity GO:0010469 9.91 CXCL8 IL1A IL1B IL4 IL6 TNF
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.88 IL1A IL1B LTF TNF
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.86 IL1B IL6 TNF
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL1B IL6 LTF TNF
9 positive regulation of JNK cascade GO:0046330 9.83 IL1A IL1B TNF
10 cellular response to lipopolysaccharide GO:0071222 9.81 CTSG CXCL8 IL6 TNF
11 positive regulation of T cell proliferation GO:0042102 9.8 IL1B IL4 IL6
12 humoral immune response GO:0006959 9.8 IL6 LTF TNF
13 defense response to Gram-positive bacterium GO:0050830 9.8 CTSG DEFB4A IL6 TNF
14 defense response to bacterium GO:0042742 9.8 CTSG DEFB4A ELANE LTF TNF
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 ELANE IL6 TNF
16 defense response to Gram-negative bacterium GO:0050829 9.76 CTSG DEFB4A IL6 LTF
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.73 IL1A IL1B TNF
18 negative regulation of lipid catabolic process GO:0050995 9.68 IL1B TNF
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
20 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.68 IL1A IL1B
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL1B TNF
22 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.67 IL1A IL1B
23 extracellular matrix disassembly GO:0022617 9.67 CTSG ELANE MMP8 MMP9
24 positive regulation of immune response GO:0050778 9.66 CTSG ELANE
25 negative regulation of lipid storage GO:0010888 9.66 IL6 TNF
26 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
27 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.65 ELANE TNF
28 ectopic germ cell programmed cell death GO:0035234 9.64 IL1A IL1B
29 regulation of establishment of endothelial barrier GO:1903140 9.64 IL1B TNF
30 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
31 fever generation GO:0001660 9.6 IL1A IL1B
32 sequestering of triglyceride GO:0030730 9.57 IL1B TNF
33 antimicrobial humoral response GO:0019730 9.56 CTSG DEFB4A ELANE LTF
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 IL1B TNF
35 negative regulation of chemokine biosynthetic process GO:0045079 9.52 ELANE IL6
36 negative regulation of growth of symbiont in host GO:0044130 9.5 CTSG ELANE TNF
37 cytokine-mediated signaling pathway GO:0019221 9.5 CXCL8 IL1A IL1B IL4 IL6 MMP9
38 positive regulation of interleukin-6 production GO:0032755 9.46 IL1A IL1B IL6 TNF
39 immune response GO:0006955 9.23 CTSG CXCL8 DEFB4A IL1A IL1B IL4
40 negative regulation of apoptotic process GO:0043066 10.06 IL4 IL6 LTF MMP9 SERPINB2
41 proteolysis GO:0006508 10.06 CTSG ELANE LTF MMP8 MMP9 PLAT

Molecular functions related to Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.87 CTSG ELANE GUSB LTF MMP8 MMP9
2 peptidase activity GO:0008233 9.63 CTSG ELANE LTF MMP8 MMP9 PLAT
3 serine-type peptidase activity GO:0008236 9.56 CTSG ELANE LTF PLAT
4 serine-type endopeptidase activity GO:0004252 9.43 CTSG ELANE LTF MMP8 MMP9 PLAT
5 interleukin-1 receptor binding GO:0005149 9.37 IL1A IL1B
6 cytokine activity GO:0005125 9.1 CXCL8 IL1A IL1B IL4 IL6 TNF
Sources

Sources for Gingivitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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