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MCID: GNG013
MIFTS: 62

Gingivitis

Categories: Gastrointestinal diseases, Oral diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Gingivitis

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MalaCards integrated aliases for Gingivitis:

Name: Gingivitis 12 76 29 55 44 15 73
Chronic Gingivitis 12 55 73
Acute Gingivitis 12 73

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:3087
ICD9CM 35 523.0 523.1
MeSH 44 D005891
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Summaries for Gingivitis

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MalaCards based summary : Gingivitis, also known as chronic gingivitis, is related to gingival disease and periapical periodontitis, and has symptoms including signs and symptoms, digestive, tenderness of gums and denture irritation. An important gene associated with Gingivitis is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Chlorhexidine and Hexetidine have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and neutrophil, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Gingivitis is a non-destructive disease that causes inflammation of the gums. The most common form of... more...

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Related Diseases for Gingivitis

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Diseases related to Gingivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 657)
# Related Disease Score Top Affiliating Genes
1 gingival disease 33.2 ELANE IL1A IL1B IL6 MMP8
2 periapical periodontitis 31.8 IL1B IL6 MMP8 TLR2 TNF
3 periodontitis 31.8 CXCL8 IL1A IL1B IL4 IL6 MMP8
4 periodontitis, chronic 31.6 IL1B IL6 MMP8 TLR2
5 periodontal disease 31.5 CXCL8 DEFB4A ELANE GUSB IL1A IL1B
6 periodontosis 30.9 CXCL8 ELANE MMP9 TNF
7 aggressive periodontitis 30.7 CXCL8 IL1A IL1B IL4 IL6 LTF
8 lichen planus 30.5 DEFB4A IL4 TNF
9 glossitis 30.1 IL1B IL6 TNF
10 acquired immunodeficiency syndrome 30.1 IL1B IL6 TNF
11 arthritis 30.0 CXCL8 IL1A IL1B IL6 MMP9 TNF
12 cerebral palsy 30.0 IL1B IL6 MMP8 TNF
13 ligneous conjunctivitis 29.9 ELANE PLAT
14 conjunctivitis 29.9 CXCL8 IL4 IL6
15 localized scleroderma 29.8 DEFB4A IL6 TNF
16 cytomegalovirus infection 29.8 CXCL8 IL1B IL6 TNF
17 monocytic leukemia 29.8 CXCL8 IL1B IL6 TNF
18 idiopathic neutropenia 29.8 IL1A IL1B IL6 TNF
19 cyclic neutropenia 29.8 CXCL8 ELANE IL1B
20 juvenile rheumatoid arthritis 29.7 IL1B IL6 TNF
21 dengue hemorrhagic fever 29.7 CXCL8 IL6 TNF
22 crohn's colitis 29.7 CXCL8 IL1B TNF
23 pulpitis 29.7 CXCL8 IL1A IL1B IL6 TNF
24 synovitis 29.6 CXCL8 IL1B IL6 TNF
25 graft-versus-host disease 29.5 IL1A IL1B IL6 TNF
26 gastric adenocarcinoma 29.5 CXCL8 IL1B MMP9 TNF
27 paracoccidioidomycosis 29.5 IL4 IL6 TLR2 TNF
28 rheumatoid arthritis 29.5 CXCL8 IL1A IL1B IL4 IL6 MMP9
29 mycobacterium tuberculosis 1 29.5 IL4 TLR2 TNF
30 pulmonary tuberculosis 29.5 IL4 TLR2 TNF
31 heart disease 29.5 CXCL8 IL1B IL6 PLAT TNF
32 osteomyelitis 29.4 CXCL8 IL1A IL1B IL6 TNF
33 leptospirosis 29.4 CXCL8 IL1B IL6 TLR2 TNF
34 chlamydia 29.4 CXCL8 IL1A IL1B IL4 IL6 TLR2
35 arteries, anomalies of 29.3 IL1B IL6 MMP9 PLAT TNF
36 aortic aneurysm, familial abdominal, 1 29.3 ELANE IL1B IL6 MMP8 MMP9
37 viral infectious disease 29.2 CXCL8 IL1B IL4 IL6 TNF
38 aphthous stomatitis 29.2 IL1B IL4 IL6 TLR2 TNF
39 multiple sclerosis 29.0 IL1B IL4 IL6 MMP9 TNF
40 tonsillitis 28.9 CXCL8 DEFB4A IL1A IL1B IL4 IL6
41 systemic lupus erythematosus 28.8 CTSG CXCL8 ELANE IL1B IL4 IL6
42 asthma 28.6 CXCL8 ELANE IL1A IL1B IL4 IL6
43 inflammatory bowel disease 27.9 CTSG CXCL8 DEFB4A ELANE IL1A IL1B
44 gingival overgrowth 12.7
45 gingival recession 12.6
46 gingival fibromatosis 12.6
47 fibromatosis, gingival, 1 12.6
48 hypertrichosis, congenital generalized, with or without gingival hyperplasia 12.6
49 necrotizing ulcerative gingivitis 12.5
50 fibromatosis, gingival, with progressive deafness 12.4

Comorbidity relations with Gingivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Dental Caries

Graphical network of the top 20 diseases related to Gingivitis:



Diseases related to Gingivitis
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Symptoms & Phenotypes for Gingivitis

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UMLS symptoms related to Gingivitis:


signs and symptoms, digestive, tenderness of gums, denture irritation

MGI Mouse Phenotypes related to Gingivitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.22 CTSG ELANE GUSB IL1A IL1B IL4
2 homeostasis/metabolism MP:0005376 10.18 ELANE GUSB IL1A IL1B IL4 IL6
3 immune system MP:0005387 10.13 CTSG ELANE IL1A IL1B IL4 IL6
4 integument MP:0010771 9.91 GUSB IL1A IL1B IL4 IL6 MMP9
5 mortality/aging MP:0010768 9.9 CTSG ELANE GUSB IL1B IL4 IL6
6 neoplasm MP:0002006 9.7 CTSG ELANE IL1A IL1B IL6 LTF
7 skeleton MP:0005390 9.23 GUSB IL1B IL4 IL6 MMP9 PLAT
Sources

Drugs & Therapeutics for Gingivitis

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Drugs for Gingivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 243)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 55-56-1 2713 9552079
2
Hexetidine Approved, Investigational Phase 4 141-94-6
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 22916-47-8 4189
4 sodium fluoride Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 7681-49-4
5
Ethanol Approved Phase 4,Phase 3,Phase 2,Not Applicable 64-17-5 702
6
Tea tree oil Approved Phase 4,Not Applicable
7
Triclosan Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 3380-34-5 5564
8
Metronidazole Approved Phase 4,Phase 3,Phase 2,Not Applicable 443-48-1 4173
9
Cetylpyridinium Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7773-52-6
10
Thymol Approved Phase 4,Not Applicable 89-83-8 6989
11
Zinc Approved, Investigational Phase 4,Phase 2,Not Applicable 7440-66-6
12
Methyl salicylate Approved, Vet_approved Phase 4,Not Applicable 119-36-8 4133
13
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
14
Vitamin C Approved, Nutraceutical Phase 4,Phase 3 50-81-7 5785 54670067
15
Eucalyptol Approved, Nutraceutical Phase 4,Not Applicable 470-82-6 2758
16
Epicatechin Investigational Phase 4 490-46-0 72276
17 Dermatologic Agents Phase 4,Phase 3,Phase 2,Not Applicable
18 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
19 Chlorhexidine gluconate Phase 4,Phase 3,Phase 2,Not Applicable
20 Disinfectants Phase 4,Phase 3,Phase 2,Not Applicable
21 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
23 Acidophilus Phase 4,Phase 3,Phase 2,Not Applicable
24 Antifungal Agents Phase 4,Phase 3,Not Applicable
25 Fluorides Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
26 Listerine Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
27 Cariostatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
28 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
29 Central Nervous System Depressants Phase 4,Not Applicable
30 Tea Tree Phase 4,Not Applicable
31 Anesthetics Phase 4,Phase 1,Not Applicable,Early Phase 1
32 Antimetabolites Phase 4,Phase 3,Phase 2,Not Applicable
33 Hypolipidemic Agents Phase 4,Phase 3,Phase 2,Not Applicable
34 Lipid Regulating Agents Phase 4,Phase 3,Phase 2,Not Applicable
35 Vitamins Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
36 Calcium, Dietary Phase 4,Not Applicable
37 Caseins Phase 4,Not Applicable
38 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
40 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
41
Tin Phase 4,Phase 3,Not Applicable 7440-31-5
42 Tin Fluorides Phase 4,Phase 3,Not Applicable
43 Antioxidants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
44
Procyanidin Phase 4 4852-22-6 147299
45 Proanthocyanidin Phase 4
46 Anthocyanidin Phase 4
47 Fluorophosphate Phase 4,Not Applicable
48 Chelating Agents Phase 4,Not Applicable
49 Salicylates Phase 4,Not Applicable
50 Aloe Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 336)
# Name Status NCT ID Phase Drugs
1 Efficacy of Different Chlorhexidine Concentrations Unknown status NCT02911766 Phase 4 Chlorhexidine 0.2% Mouthrinse;Chlorhexidine 0.12% mouthrinse;Chlorhexidine 0.06% mouthrinse
2 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). Unknown status NCT01778699 Phase 4
3 Methodology Antiseptic Application, Influence on Oral Biofilm. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
4 Antiplaque Effect of Essential Oils With and Without Alcochol on an in Situ Model of Oral Biofilm Growth Unknown status NCT02946801 Phase 4 Essential oils;Essential oils without alcohol;Sterile water
5 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
6 Effect of Different Mouthrinses in Plaque Formation Unknown status NCT02695901 Phase 4 Chlorhexidine gluconate 0.12% (PerioGard®);Nanoparticle solution of M. alternifolia oil (0.3%).
7 Periodontal Therapy in Coronary Artery Patients Unknown status NCT01609725 Phase 4
8 Effectiveness of Metronidazole Gel and Mobile SMS Reminders on Gingivitis in Orthodontic Patients Completed NCT03508999 Phase 4 Metronidazole gel
9 The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Completed NCT02360995 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride toothpaste;Fluoride Mouthwash;cetylpyridinium chloride Mouthwash
10 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With OPCs Completed NCT02515929 Phase 4
11 Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash) Completed NCT02366689 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride only toothpaste;Cetylpyridinium chloride mouthwash;Fluoride only mouthwash
12 Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste Completed NCT02080273 Phase 4 Colgate Cavitity Protection toothpaste;Colgate Total toothpaste;Parodontax toothpaste
13 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00855933 Phase 4
14 Essential Oil+ELA, Plaque and Gingivitis Completed NCT02884817 Phase 4 Experimental: essential oils and ELA
15 Effects of Two Sugar Substituted Chewing Gums on Caries and Gingivitis Variables Completed NCT01578603 Phase 4
16 Evaluate Inflammation Caused by Gingivitis in Adults Completed NCT00941668 Phase 4 Triclosan/Copolymer/fluoride toothpaste;sodium monofluorophosphate toothpaste
17 A Clinical Trial to Test the Effect of Experimental Mouth Rinse on Gum Disease Completed NCT02065414 Phase 4
18 Effect of Mouthrinsing on Inflammation of the Gums. Completed NCT01317446 Phase 4 amine fluoride/stannous fluoride
19 Estimation of Interleukin-21 Levels in Gingival Crevicular Fluid in Patients With Periodontal Health and Disease Following Non-surgical Periodontal Therapy: A Clinico-biochemical Study Completed NCT02861937 Phase 4
20 Compare Anti-inflammatory Dentifrices Completed NCT00762528 Phase 4 Triclosan/Copolymer/fluoride toothpaste;Sodium monofluorophosphate toothpaste
21 Bacteremia in Periodontal Patients Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
22 "The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients. Completed NCT02154594 Phase 4 Acacia catechu;Chlorhexidine gluconate
23 Mechanical-chemical Gingival Therapy in Diabetics and/or Obese Completed NCT02123563 Phase 4
24 An Efficacy Study of Chlorhexidine Mouthwashes Completed NCT01751178 Phase 4 Chlorhexidine Digluconate Mouthwash with Alcohol;Chlorhexidine Digluconate Mouthwash without Alcohol
25 Aloe Vera and Chlorhexidine Against Traumatic Oral Ulcers Completed NCT03633292 Phase 4 Antiseptic clorhexidine gel (Lacer, Barcelona, Spain);Master formula of aloe vera gel 80%
26 Clinical Examination of Metal Free Interdental Brushes Completed NCT01593540 Phase 4
27 Effect of Probiotic on the Plaque pH. A Randomized Double Blind Interventional Study Completed NCT01601145 Phase 4
28 Effects Of Chlorhexidine Mouthrinse On Peridontopathogens: A Randomized, Placebo-Controlled Study Completed NCT01213550 Phase 4 Chlorhexidine gluconate;Placebo mouthrinse
29 Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. Completed NCT02124655 Phase 4 Essential oils;0.2% chlorhexidine;Sterile water
30 Study to Evaluate Clinical Efficacy and Safety of Bio Mineral Toothpaste in Patients With Mild Periodontitis Completed NCT01548469 Phase 4
31 Evaluation of Photodynamic Treatment FOTOSAN® Efficacy in Periodontology Completed NCT02030470 Phase 4
32 Interaction Between Chlorhexidine and Fluoride Completed NCT02935322 Phase 4 0.12 % chlorhexidine + 0.2 % NaF mouthrinse;0.2 % NaF mouthrinse;0.12% chlorhexidine
33 Effect of Fibrin Sealant on Early Wound Healing Completed NCT01538927 Phase 4 Fibrin Sealant;Suture
34 Treatment of Peri-implantitis Lesions by Using Biomaterial Completed NCT02375750 Phase 4
35 The Influence of Citric Acid Bone Surface Etching and Bone Defect Fill on GCF BMP-2 Release Profile Completed NCT03769402 Phase 4 Citric acid;Control Test
36 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis Active, not recruiting NCT03219840 Phase 4 CPC;Placebo
37 Randomized Trial to Evaluate the Efficacy of Two Different Toothbrushes on Plaque Control Active, not recruiting NCT03099551 Phase 4
38 Impact of Oral Hygiene Gels on Peri-implant Mucositis Active, not recruiting NCT03243591 Phase 4
39 Porous Metronidazole Loaded Matrix for Local Treatment of Periodontitis. Active, not recruiting NCT03791099 Phase 4 Metronidazole
40 Mouthwashes During Orthodontic Treatment Enrolling by invitation NCT03179735 Phase 4 Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
41 Evaluation and Comparison of Efficacy of PeriActive Mouthwash to Chlorhexidine 0.12% Mouth Rinse Not yet recruiting NCT02987634 Phase 4
42 Evaluation of The Effect of Live Probiotic Cultures Present in Fermented Dairy Product (Yogurt) Versus The Effect of Freeze-Dried Probiotic Sachets on Gingival Bleeding, Dental Plaque pH and Oral Health of Adolescents Not yet recruiting NCT03640065 Phase 4 freeze-dried probiotic sachets
43 Efficacy of a Mouthwash Containing Propolis Unknown status NCT01750801 Phase 3 Propolis;chlorhexidine
44 Comparative Efficacy of a Toothpaste That Reduces Plaque and Gingivitis Completed NCT00926328 Phase 3 Triclosan, fluoride;Fluoride
45 Effects of Antioxidant Dentifrice on Gingivitis Completed NCT02102295 Phase 3 Experimental toothpaste;Control toothpaste
46 The Effect of Mouthrinses Containing Bamboo Salt, Magnolia Bark and Centella Asiatica on Reducing Plaque and Gingivitis Completed NCT03047798 Phase 3 Mouthrinse
47 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00964860 Phase 3
48 The Clinical Efficacy of Three Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Dental Plaque and Gingivitis Completed NCT02193165 Phase 3 triclosan/fluoride toothpaste + cetylpyridinium chloride Mouthwash;stannous fluoride toothpaste + cetylpyridinium chloride Mouthwash;fluoride toothpaste + fluoride Mouthwash
49 The Effect of New Dentifrices Containing Centella Asiatica and Bamboo Salt on Reducing Plaque and Gingivitis Completed NCT02616042 Phase 3
50 Clinical Study to Evaluate the Treatment of Gingivitis of Two Toothpastes Completed NCT00762515 Phase 3 Fluoride;Triclosan;Fluoride

Search NIH Clinical Center for Gingivitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: gingivitis

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Genetic Tests for Gingivitis

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Genetic tests related to Gingivitis:

# Genetic test Affiliating Genes
1 Gingivitis 29
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Anatomical Context for Gingivitis

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MalaCards organs/tissues related to Gingivitis:

41
Testes, Heart, Neutrophil, Endothelial, B Cells, Bone, Liver
Sources

Publications for Gingivitis

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Articles related to Gingivitis:

(show top 50) (show all 1149)
# Title Authors Year
1
Evidence-Based Update on Diagnosis and Management of Gingivitis and Periodontitis. ( 30447793 )
2019
2
Effect of Initial Periodontal Therapy on Salivary Trefoil Factor (TFF3) in otherwise Healthy Patients with Gingivitis and Chronic Periodontitis. ( 29962757 )
2018
3
Desquamative gingivitis: Diagnosis and treatment. ( 29678379 )
2018
4
Effect of guava and vitamin C supplementation on experimental gingivitis: A randomized clinical trial. ( 29757462 )
2018
5
Components in Lentinus edodes mushroom with anti-biofilm activity directed against bacteria involved in caries and gingivitis. ( 29882939 )
2018
6
The effects of essential oil mouthrinses with or without alcohol on plaque and gingivitis: a randomized controlled clinical study. ( 29321067 )
2018
7
Influence of Photobiomodulation Therapy on Gingivitis Induced by Multi-Bracket Appliances: A Split-Mouth Randomized Controlled Trial. ( 29775553 )
2018
8
Effects of Kangfuxin solution on IL-1I^, IL-6, IL-17 and TNF-I+ in gingival crevicular fluid in patients with fixed orthodontic gingivitis. ( 29896253 )
2018
9
Tobacco smoking decreases clinical symptoms of gingivitis in patients with type 1 diabetes-a cross-sectional study. ( 29757485 )
2018
10
Six-Month Evaluation of a Sodium Bicarbonate-Containing Toothpaste for Reduction of Established Gingivitis: A Randomized USA-Based Clinical Trial. ( 29758155 )
2018
11
An 8-Week Clinical Comparison of an Oscillating-Rotating Electric Rechargeable Toothbrush and a Sonic Toothbrush in the Reduction of Gingivitis and Plaque. ( 29758154 )
2018
12
Prevalence of gingivitis and calculus in 12-year-old Puerto Ricans: a cross-sectional study. ( 29351752 )
2018
13
Desquamative gingivitis: Clinical findings and diseases. ( 29678378 )
2018
14
Effectiveness of two different herbal toothpaste formulations in the reduction of plaque and gingival inflammation in patients with established gingivitis - A randomized controlled trial. ( 29321998 )
2018
15
Adjunct Use of Low-Level Laser Therapy on the Treatment of Necrotizing Ulcerative Gingivitis: A Case Report. ( 29399316 )
2018
16
Molecular basis for immunohistochemical and inflammatory changes during progression of gingivitis to periodontitis. ( 29194785 )
2018
17
The effect of dietary corn oil and fish oil supplementation in dogs with naturally occurring gingivitis. ( 29908038 )
2018
18
Plaque-induced gingivitis: Case definition and diagnostic considerations. ( 29926492 )
2018
19
Necrotizing fungal gingivitis in a patient with Acute Myelogenous Leukemia: visible yet obscure. ( 29404266 )
2018
20
Gingival crevicular fluid and salivary resistin and tumor necrosis factor-alpha levels in obese children with gingivitis. ( 29635809 )
2018
21
A 12-week randomized clinical study investigating the anti-gingivitis efficacy of a 0.454% w/w stannous fluoride dentifrice. ( 29630791 )
2018
22
Microbiota and Metatranscriptome Changes Accompanying the Onset of Gingivitis. ( 29666288 )
2018
23
A 24-week randomized clinical study investigating the anti-gingivitis efficacy of a 0.454% w%#47;w stannous fluoride dentifrice. ( 29630800 )
2018
24
Impact of gingivitis treatment for diabetic patients on quality of life related to periodontal objective parameters: A randomized controlled clinical trial. ( 29197785 )
2018
25
Predictors of dental plaque and gingivitis in patients receiving integrated dental treatment-a longitudinal retrospective study. ( 29740720 )
2018
26
Plaque-induced gingivitis: Case definition and diagnostic considerations. ( 29926936 )
2018
27
Association between dental hygiene, gingivitis and overweight or the risk of overweight in primary teeth of 4- and 5-year-old preschoolers in MAcxico. ( 29687632 )
2018
28
Effects of Huanglian Jiedu Decoration in Rat Gingivitis. ( 29576800 )
2018
29
Body fat rather than body mass index is associated with gingivitis - A southern Brazilian cross-sectional study. ( 29603230 )
2018
30
An Analytical Method for Assessing Optimal Storage Conditions of Gingival Crevicular Fluid and Disclosing a Peptide Biomarker Signature of Gingivitis by MALDI-TOF MS. ( 29603653 )
2018
31
Annexin-1 as a salivary biomarker for gingivitis during pregnancy. ( 29608211 )
2018
32
Prevalence of Plaque-Induced Gingivitis in a Sample of the Adult Egyptian Population. ( 29610619 )
2018
33
Salivary exRNA biomarkers to detect gingivitis and monitor disease regression. ( 29779262 )
2018
34
Exploring Self-Care Needs of Pregnant Women with Gingivitis: A Qualitative Study in Iran. ( 30034490 )
2018
35
The relationship between oral hygiene level and gingivitis in children. ( 30058781 )
2018
36
Interaction between stress, cytokines, and salivary cortisol in pregnant and non-pregnant women with gingivitis. ( 30066030 )
2018
37
Innate lymphoid cells are present in gingivitis and periodontitis. ( 30070705 )
2018
38
Association between gingivitis severity and lifestyle habits in young Saudi Arabian males. ( 30079945 )
2018
39
Randomized controlled trial evaluating concurrent gingivitis and stain effects of a two-step dentifrice/gel sequence. ( 30106528 )
2018
40
Post-prophylaxis gingivitis prevention with two-step stannous fluoride dentifrice plus whitening gel sequence or chlorhexidine gluconate mouthrinse. ( 30106529 )
2018
41
A 6-month clinical evaluation of a high frequency sonic toothbrush in comparison with an oscillating-rotating power toothbrush and a traditional sonic toothbrush in reducing gingivitis and plaque. ( 30106531 )
2018
42
Necrotising Ulcerative Gingivitis: A Rare Manifestation of Pseudomonas Infection. ( 30127583 )
2018
43
Strawberry Gingivitis: A rare manifestation of granulomatosis with polyangiitis. ( 30137535 )
2018
44
Development and evaluation of mucoadhesive buccal tablet containing metronidazole for the treatment of periodontitis and gingivitis. ( 30150187 )
2018
45
Efficacy of herbal dentifrice on the prevention of plaque and gingivitis as compared to conventional dentifrice: A systematic review and meta-analysis. ( 30210185 )
2018
46
Comparative evaluation of efficacy of Murraya koenigii and chlorhexidine gluconate in the treatment of gingivitis: A randomized controlled clinical trial. ( 30210192 )
2018
47
Gingivitis Models - Relevant Approaches to Assess Oral Hygiene Products. ( 30211990 )
2018
48
The Efficacy of Aged Garlic Extract on Gingivitis - A Randomized Clinical Trial. ( 30211991 )
2018
49
A Randomized Controlled Clinical Trial to Evaluate the Efficacy of an Oscillating-Rotating Electric Toothbrush, a Stannous Fluoride Dentifrice, and Floss on Gingivitis. ( 30211993 )
2018
50
Effects of oral prophylaxis including tongue cleaning on halitosis and gingival inflammation in gingivitis patients-a randomized controlled clinical trial. ( 30218226 )
2018
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Variations for Gingivitis

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Expression for Gingivitis

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Search GEO for disease gene expression data for Gingivitis.
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Pathways for Gingivitis

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Pathways related to Gingivitis according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14 CTSG CXCL8 DEFB4A ELANE GUSB IL1A
2
Akt Signaling 64
Show member pathways
 13.42 CXCL8 IL1A IL1B IL4 IL6 TLR2
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.38 CXCL8 IL1A IL1B IL4 IL6 MMP9
4
PAK Pathway 64
Show member pathways
 13.29 CXCL8 IL1A IL1B IL4 IL6 TNF
5
Human cytomegalovirus infection 37
Show member pathways
 13.09 CXCL8 IL1B IL6 MMP9 TLR2 TNF
6
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 13 CXCL8 IL1B IL6 TLR2 TNF
7
Allograft rejection 1 37
Show member pathways
 12.92 CXCL8 IL1A IL1B IL4 IL6 TNF
8
Influenza A 37
Show member pathways
 12.86 CXCL8 IL1A IL1B IL4 IL6 TLR2
9
NF-KappaB Family Pathway 64
Show member pathways
 12.74 IL1A IL1B IL6 TLR2 TNF
10
Th17 cell differentiation 37
Show member pathways
 12.66 IL1A IL1B IL4 IL6 TLR2 TNF
11
NF-kappaB Signaling 4
12.56 IL1B IL4 TLR2 TNF
12
T cell receptor signaling pathway 37
Show member pathways
 12.49 IL1A IL1B IL4 IL6 TNF
13
Defensins 66
Show member pathways
 12.43 CTSG DEFB4A ELANE LTF TLR2
14
Selenium Micronutrient Network 1
Show member pathways
 12.4 IL1B IL4 IL6 PLAT TNF
15
Toll Comparative Pathway 64
Show member pathways
 12.38 CXCL8 IL1A IL1B IL6 TNF
16
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.34 CXCL8 IL1A IL6 TLR2 TNF
17
Toxoplasmosis 37
Show member pathways
 12.33 IL1A IL1B IL4 TLR2 TNF
18
Transcriptional misregulation in cancer 37
12.33 CXCL8 ELANE IL6 MMP9 PLAT
19
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.33 CXCL8 IL1A IL1B IL4 IL6 TNF
20
Tuberculosis 37
12.31 IL1A IL1B IL6 TLR2 TNF
21
IL-1 Family Signaling Pathways 65
Show member pathways
 12.3 CXCL8 IL1A IL1B IL6 TLR2 TNF
22
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 12.28 CXCL8 IL1A IL1B MMP8 MMP9 TLR2
23
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.26 CXCL8 IL1A IL1B IL6 TNF
24
Colorectal Cancer Metastasis 64
12.23 IL6 MMP9 TLR2 TNF
25
Bacterial infections in CF airways 22
Show member pathways
 12.19 CXCL8 DEFB4A IL1B IL4 IL6 TLR2
26
Fluid shear stress and atherosclerosis 37
12.18 IL1A IL1B MMP9 PLAT TNF
27
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.12 CXCL8 IL1A IL1B IL4 IL6
28
Th1 Differentiation Pathway 65
Show member pathways
 12.12 IL1B IL6 TLR2 TNF
29
TNF signaling pathway 37
12.03 IL1B IL6 MMP9 TNF
30
MAPK Pathway 72
Show member pathways
 12.02 IL1A IL1B TLR2
31
Senescence and Autophagy in Cancer 1
12.01 CXCL8 IL1A IL1B IL6 PLAT SERPINB2
32
AGE-RAGE signaling pathway in diabetic complications 37
12 CXCL8 IL1A IL1B IL6 TNF
33
Matrix Metalloproteinases 1
Show member pathways
 12 CTSG ELANE MMP8 MMP9 TNF
34
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.99 IL4 IL6 TNF
35
Hematopoietic cell lineage 37
11.98 IL1A IL1B IL4 IL6 TNF
36
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 11.97 IL1B IL4 IL6 MMP9 PLAT TLR2
37
Amoebiasis 37
11.95 CTSG CXCL8 IL1B IL6 TLR2 TNF
38
Salmonella infection (KEGG) 37
11.91 CXCL8 IL1A IL1B IL6
39
Rheumatoid arthritis 37
11.91 CXCL8 IL1A IL1B IL6 TLR2 TNF
40
NF-kappa B signaling pathway 37
11.89 CXCL8 IL1B TNF
41
Spinal Cord Injury 1
11.88 CXCL8 IL1A IL1B IL4 IL6 MMP9
42
Pertussis 37
11.86 CXCL8 IL1A IL1B IL6 TNF
43
Glucocorticoid receptor regulatory network 1
11.83 CXCL8 IL4 IL6
44
Innate Lymphoid Cell Differentiation Pathways 65
11.82 IL1B IL4 TNF
45
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.82 IL1B IL4 IL6 MMP9 TNF
46
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.79 CXCL8 IL4 TNF
47
Dendritic Cells Developmental Lineage Pathway 65
11.78 IL1B IL6 TNF
48
LPA receptor mediated events 1
11.72 CXCL8 IL6 MMP9
49
Cell adhesion_ECM remodeling 22
11.69 CXCL8 MMP9 PLAT
50
Legionellosis 37
11.69 CXCL8 IL1B IL6 TLR2 TNF
Sources

GO Terms for Gingivitis

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Cellular components related to Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 CTSG CXCL8 DEFB4A ELANE GUSB IL1A
2 cell surface GO:0009986 9.8 CTSG ELANE LTF PLAT TLR2 TNF
3 collagen-containing extracellular matrix GO:0062023 9.65 CTSG ELANE MMP8 MMP9 PLAT
4 azurophil granule lumen GO:0035578 9.61 CTSG ELANE GUSB
5 specific granule lumen GO:0035580 9.58 ELANE LTF MMP8
6 secretory granule GO:0030141 9.55 CTSG ELANE IL1B LTF PLAT
7 tertiary granule lumen GO:1904724 9.54 LTF MMP8 MMP9
8 extracellular space GO:0005615 9.5 CTSG CXCL8 DEFB4A ELANE GUSB IL1A

Biological processes related to Gingivitis according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.98 CTSG DEFB4A ELANE LTF TNF
2 leukocyte migration GO:0050900 9.97 ELANE IL1B MMP9 TNF
3 response to lipopolysaccharide GO:0032496 9.95 CTSG ELANE IL1B TLR2
4 neutrophil degranulation GO:0043312 9.95 CTSG ELANE GUSB LTF MMP8 MMP9
5 positive regulation of gene expression GO:0010628 9.91 IL1A IL1B IL4 IL6 MMP8 TLR2
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.89 IL1B IL6 TNF
7 cellular response to lipopolysaccharide GO:0071222 9.89 CTSG CXCL8 IL1B IL6 TNF
8 positive regulation of JNK cascade GO:0046330 9.88 IL1B MMP8 TNF
9 response to glucocorticoid GO:0051384 9.87 IL1B IL6 TNF
10 defense response to Gram-negative bacterium GO:0050829 9.87 CTSG DEFB4A IL6 LTF
11 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.86 CXCL8 DEFB4A LTF
12 positive regulation of T cell proliferation GO:0042102 9.85 IL1B IL4 IL6
13 humoral immune response GO:0006959 9.85 IL6 LTF TNF
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 ELANE IL6 TNF
15 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B IL6 LTF TLR2 TNF
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IL1B MMP8 TNF
17 extracellular matrix disassembly GO:0022617 9.81 CTSG ELANE MMP8 MMP9
18 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.79 IL1A IL1B TNF
19 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 IL1B TLR2 TNF
20 antimicrobial humoral response GO:0019730 9.78 CTSG DEFB4A ELANE LTF
21 positive regulation of interleukin-8 production GO:0032757 9.77 IL1B TLR2 TNF
22 negative regulation of neurogenesis GO:0050768 9.77 IL1B IL6 TNF
23 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.76 IL1B MMP8 TLR2 TNF
24 positive regulation of chemokine production GO:0032722 9.75 IL6 TLR2 TNF
25 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
26 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IL1B TNF
28 positive regulation of glial cell proliferation GO:0060252 9.72 IL1B IL6 TNF
29 defense response to Gram-positive bacterium GO:0050830 9.72 CTSG DEFB4A IL6 TLR2 TNF
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL1B TNF
31 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.71 IL1A IL1B
32 response to molecule of bacterial origin GO:0002237 9.71 CXCL8 TLR2
33 negative regulation of growth of symbiont in host GO:0044130 9.71 CTSG ELANE TNF
34 positive regulation of immune response GO:0050778 9.7 CTSG ELANE
35 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.7 ELANE TNF
36 negative regulation of lipid storage GO:0010888 9.7 IL6 TNF
37 cytokine-mediated signaling pathway GO:0019221 9.7 CXCL8 IL1A IL1B IL4 IL6 MMP9
38 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
39 ectopic germ cell programmed cell death GO:0035234 9.68 IL1A IL1B
40 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
41 positive regulation of fever generation GO:0031622 9.66 IL1B TNF
42 regulation of neuroinflammatory response GO:0150077 9.66 MMP8 MMP9
43 chronic inflammatory response to antigenic stimulus GO:0002439 9.65 IL1B TNF
44 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B IL6 MMP8 TLR2 TNF
45 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
46 fever generation GO:0001660 9.63 IL1A IL1B
47 negative regulation of chemokine biosynthetic process GO:0045079 9.63 ELANE IL6
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IL1B TNF
49 regulation of microglial cell activation GO:1903978 9.62 MMP8 TNF
50 immune response GO:0006955 9.28 CTSG CXCL8 DEFB4A IL1A IL1B IL4

Molecular functions related to Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.91 CTSG ELANE GUSB LTF MMP8 MMP9
2 peptidase activity GO:0008233 9.63 CTSG ELANE LTF MMP8 MMP9 PLAT
3 serine-type peptidase activity GO:0008236 9.56 CTSG ELANE LTF PLAT
4 endopeptidase activity GO:0004175 9.5 ELANE MMP8 MMP9
5 serine-type endopeptidase activity GO:0004252 9.43 CTSG ELANE LTF MMP8 MMP9 PLAT
6 interleukin-1 receptor binding GO:0005149 9.4 IL1A IL1B
7 cytokine activity GO:0005125 9.1 CXCL8 IL1A IL1B IL4 IL6 TNF
Sources

Sources for Gingivitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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