MCID: GNG013
MIFTS: 59

Gingivitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Gingivitis

MalaCards integrated aliases for Gingivitis:

Name: Gingivitis 12 74 29 54 43 15 71
Chronic Gingivitis 12 54 71 32
Acute Gingivitis 12 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:3087
ICD9CM 34 523.0 523.1
MeSH 43 D005891
UMLS 71 C0008684 C0017574 C0155937

Summaries for Gingivitis

MalaCards based summary : Gingivitis, also known as chronic gingivitis, is related to gingival recession and gingival fibromatosis, and has symptoms including signs and symptoms, digestive, tenderness of gums and denture irritation. An important gene associated with Gingivitis is MMP8 (Matrix Metallopeptidase 8), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and neutrophil, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 Gingivitis is a non-destructive disease that causes inflammation of the gums. The most common form of... more...

Related Diseases for Gingivitis

Diseases related to Gingivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1281)
# Related Disease Score Top Affiliating Genes
1 gingival recession 35.1 MMP8 IL6 IL1B
2 gingival fibromatosis 34.8 TIMP1 MMP1 IL6
3 gingival overgrowth 34.4 TNF TIMP1 MMP8 MMP1 IL6 IL1A
4 periodontitis, chronic 33.6 MMP8 MMP1 IL6 IL1B
5 periodontitis, aggressive, 1 32.9 MMP8 MMP1 LTF IL1A
6 cyclic neutropenia 32.7 TNF IL1B ELANE CXCL8
7 orofacial granulomatosis 32.6 TNF IL4 IL10
8 severe congenital neutropenia 32.1 TNF IL1B ELANE CTSG
9 gingival disease 31.9 TNF TLR2 TIMP1 MMP9 MMP8 MMP1
10 periodontitis 31.6 TNF TLR2 TIMP1 MMP9 MMP8 MMP1
11 acute pericementitis 31.2 TLR2 IL1B DEFB4A
12 pemphigus 31.2 TNF IL6 IL4 IL10
13 bone resorption disease 31.1 TNF IL6 IL1B
14 osteonecrosis 31.0 TNF MMP8 IL1B IL10
15 aggressive periodontitis 31.0 TNF TLR2 MMP8 MMP1 IL6 IL4
16 stomatitis 31.0 TNF IL6 IL4 IL1B IL10 CXCL8
17 allergic hypersensitivity disease 31.0 TNF IL4 IL10 CXCL8
18 glossitis 30.9 TNF IL6 IL1B
19 root resorption 30.9 MMP9 IL6 IL4 IL1B IL1A
20 lichen planus 30.9 TNF TLR2 IL6 IL4 IL10 DEFB4A
21 ligneous conjunctivitis 30.9 PLAT ELANE
22 acquired immunodeficiency syndrome 30.8 TNF IL6 IL1B IL10
23 monocytic leukemia 30.8 TNF IL6 IL1B CXCL8
24 purpura 30.7 TNF IL6 IL4 IL10
25 oral candidiasis 30.7 LTF IL1A DEFB4A CXCL8
26 oral submucous fibrosis 30.6 TNF TIMP1 MMP9 MMP8
27 graft-versus-host disease 30.6 TNF IL6 IL1B IL1A IL10
28 granulomatosis with polyangiitis 30.6 TNF TLR2 ELANE CTSG
29 cytomegalovirus infection 30.6 TNF IL6 IL1B CXCL8
30 infective endocarditis 30.6 TNF TLR2 IL6
31 pharyngitis 30.5 TNF IL6 IL1B CXCL8
32 chronic graft versus host disease 30.5 IL1A IL10
33 elephantiasis 30.5 IL4 IL10 ELANE
34 systemic scleroderma 30.5 TNF IL6 IL4 IL1B IL10
35 plague 30.5 TNF TLR2 IL6 IL1B IL10
36 leukemia, acute monocytic 30.5 TNF TLR2 IL6 IL1B CXCL8
37 mental depression 30.4 TNF IL6 IL1B
38 exanthem 30.4 TNF IL6 IL1B IL10 CXCL8
39 post-transplant lymphoproliferative disease 30.4 TNF IL6 IL1A IL10
40 haemophilus influenzae 30.4 TNF TLR2 LTF CXCL8
41 liver disease 30.4 TNF IL6 IL1B IL1A CXCL8
42 pulpitis 30.3 TNF TIMP1 MMP1 IL6 IL1B IL1A
43 spinal cord injury 30.3 TNF MMP9 IL6 CXCL8
44 arteriovenous malformation 30.3 TNF MMP9 IL6 IL1B
45 atherosclerosis susceptibility 30.3 TNF PLAT MMP9 IL6 IL1B CXCL8
46 mixed connective tissue disease 30.3 TNF IL6 IL10
47 mycobacterium tuberculosis 1 30.3 TNF TLR2 IL4 IL10 DEFB4A
48 chlamydia pneumonia 30.3 TNF TLR2 IL6 IL1B IL10 CXCL8
49 neutropenia 30.3 TNF IL6 IL1B IL10 GUSB ELANE
50 erythema multiforme 30.2 TNF IL6 IL4 CXCL8

Comorbidity relations with Gingivitis via Phenotypic Disease Network (PDN):


Acute Cystitis Dental Caries

Graphical network of the top 20 diseases related to Gingivitis:



Diseases related to Gingivitis

Symptoms & Phenotypes for Gingivitis

UMLS symptoms related to Gingivitis:


signs and symptoms, digestive, tenderness of gums, denture irritation

MGI Mouse Phenotypes related to Gingivitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 CTSG ELANE GUSB IL10 IL1A IL1B
2 homeostasis/metabolism MP:0005376 10.27 ELANE GUSB IL10 IL1A IL1B IL4
3 immune system MP:0005387 10.22 CTSG ELANE IL10 IL1A IL1B IL4
4 integument MP:0010771 10 ELANE GUSB IL10 IL1A IL1B IL4
5 neoplasm MP:0002006 10 CTSG ELANE IL10 IL1A IL1B IL6
6 respiratory system MP:0005388 9.61 IL10 IL4 IL6 LPO MMP9 PLAT
7 skeleton MP:0005390 9.36 GUSB IL10 IL1B IL4 IL6 MMP9

Drugs & Therapeutics for Gingivitis

Drugs for Gingivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 203)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Racepinephrine Approved Phase 4 329-65-7 838
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
5
Menthol Approved Phase 4 2216-51-5 16666
6
Ethanol Approved Phase 4 64-17-5 702
7
Triclosan Approved, Investigational Phase 4 3380-34-5 5564
8
Cetylpyridinium Approved Phase 4 7773-52-6
9
Thymol Approved Phase 4 89-83-8 6989
10
Hexetidine Approved, Investigational Phase 4 141-94-6
11
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
12
Methyl salicylate Approved, Vet_approved Phase 4 119-36-8 4133
13
Metronidazole Approved Phase 4 443-48-1 4173
14
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
15
Epicatechin Investigational Phase 4 490-46-0, 35323-91-2 72276
16 Tea Tree Phase 4
17 Photosensitizing Agents Phase 4
18 Epinephryl borate Phase 4
19 Vitamins Phase 4
20 Hormones Phase 4
21 Anti-Infective Agents, Local Phase 4
22 Calcium, Dietary Phase 4
23 Anesthetics Phase 4
24 Fluorides Phase 4
25 Chlorhexidine gluconate Phase 4
26 Protective Agents Phase 4
27 Dermatologic Agents Phase 4
28 Disinfectants Phase 4
29 Lipid Regulating Agents Phase 4
30 Fluorophosphate Phase 4
31 Hypolipidemic Agents Phase 4
32 Antimetabolites Phase 4
33 Pharmaceutical Solutions Phase 4
34 Antiprotozoal Agents Phase 4
35 Acidophilus Phase 4
36 Antioxidants Phase 4
37 Aloe Phase 4
38 Caseins Phase 4
39 Chelating Agents Phase 4
40 Adjuvants, Immunologic Phase 4
41 Viscosupplements Phase 4
42 Immunologic Factors Phase 4
43 Salicylates Phase 4
44 Antiparasitic Agents Phase 4
45 Anesthetics, Local Phase 4
46
Procyanidin Phase 4 4852-22-6 147299
47 Anthocyanidin Phase 4
48 Proanthocyanidin Phase 4
49 Tin Fluorides Phase 4
50
Tea tree oil Experimental, Nutraceutical Phase 4 68647-73-4

Interventional clinical trials:

(show top 50) (show all 376)
# Name Status NCT ID Phase Drugs
1 Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth. A Randomized Clinical Trial Unknown status NCT02946801 Phase 4 Essential oils;Essential oils without alcohol;Sterile water
2 Randomized Trial to Evaluate the Efficacy of Two Different Toothbrushes on Plaque Control Unknown status NCT03099551 Phase 4
3 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
4 Mouthwashes as Positive Modulators of Periodontal Response During Orthodontic Treatment: a 6-month Randomized Placebo Controlled Clinical Trial Unknown status NCT03179735 Phase 4 Essential oils;Cetylpyridinium Chloride 0.7 mg/ml;Placebos
5 Comparing the Effect of 0,06 % -, 0,12 % and 0,2 % Chlorhexidine on Plaque, Bleeding and Side Effects in an Experimental Gingivitis Model. A Parallel, Double Masked, Randomized, Placebo-controlled Clinical Trial Unknown status NCT02911766 Phase 4 Chlorhexidine 0.2% Mouthrinse;Chlorhexidine 0.12% mouthrinse;Chlorhexidine 0.06% mouthrinse
6 Phase IV Study to Evaluate and Compare the Efficacy of PeriActive Mouthwash to Chlorhexidine 0.12% Rinse With Regards to Managing Post-surgical Inflammation Associated With Dental Implant Surgery Unknown status NCT02987634 Phase 4
7 Photodynamic Disinfection in Combination With Scaling and Root Planing in the Treatment of Chronic Periodontitis Unknown status NCT00297531 Phase 4
8 Clinical Outcomes Following Non-Surgical Treatment of Chronic Periodontitis, Using Scaling and Root Planing (SRP) in Conjunction With PerioWave, Compared to SRP Alone Unknown status NCT00296881 Phase 4
9 Methodology of Application and Immediate Effect of the Essential Oils and 0.2% Chlorhexidine on Oral Biofilm: Immersion Versus Mouthwash. Unknown status NCT02267239 Phase 4 essential oils, immersion;Chlorhexidine, immersion;essential oils, mouthwash;chlorhexidine, mouthwash
10 Clinical, Microbiological and Biochemical Effects of the Antimicrobial Photodynamic Therapy Unknown status NCT01532674 Phase 4
11 Anti-plaque Effect of 0.12% Chlorhexidine Gluconate Rinsing and Nanoparticle Solution of 0.3% Melaleuca Alternifolia: A Randomized Crossover Clinical Trial Unknown status NCT02695901 Phase 4 Chlorhexidine gluconate 0.12% (PerioGard®);Nanoparticle solution of M. alternifolia oil (0.3%).
12 Anticaries Effect of Probiotic Lactobacillus Brevis CD2 (Lb CD2). A Randomized Double Blind Interventional Study. Unknown status NCT01778699 Phase 4
13 Estimation of Interleukin-21 Levels in Gingival Crevicular Fluid in Patients With Periodontal Health and Disease Following Non-surgical Periodontal Therapy: A Clinico-biochemical Study Completed NCT02861937 Phase 4
14 Compare Anti-inflammatory Dentifrices Completed NCT00762528 Phase 4 Triclosan/Copolymer/fluoride toothpaste;Sodium monofluorophosphate toothpaste
15 A Controlled Clinical Study to Determine the Gingivitis Benefit of Flossing Completed NCT00855933 Phase 4
16 A 3-Month Clinical Study to Assess the Plaque and Gingivitis Effects of a Stannous Fluoride Dentifrice Completed NCT03936569 Phase 4 Marketed Toothpaste;Marketed Cavity Protection Toothpaste
17 A 3-Month Clinical Study to Assess the Effects of a Stannous Fluoride Dentifrice on Plaque and Gingivitis Completed NCT03936556 Phase 4 Marketed toothpaste;Marketed Cavity Protection Toothpaste
18 Evaluate Inflammation Caused by Gingivitis in Adults Completed NCT00941668 Phase 4 Triclosan/Copolymer/fluoride toothpaste;sodium monofluorophosphate toothpaste
19 "The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients. Completed NCT02154594 Phase 4 Acacia catechu;Chlorhexidine gluconate
20 Antiplaque Effect of Essential Oils and 0.2% Chlorhexidine on an in Situ Model of Oral Biofilm Growth: a Randomised Clinical Trial. Completed NCT02124655 Phase 4 Essential oils;0.2% chlorhexidine;Sterile water
21 Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride Toothpaste in Reducing Plaque and Gingivitis - a Three Month Study Completed NCT04033575 Phase 4 Colgate Total SF;Colgate Cavity Protection toothpaste
22 Clinical Study to Evaluate the Efficacy of Chlorhexidine Mouthwashes Completed NCT01751178 Phase 4 Chlorhexidine Digluconate Mouthwash with Alcohol;Chlorhexidine Digluconate Mouthwash without Alcohol
23 Effect of an Amine Fluoride/Stannous Fluoride Containing Mouthrinse on Gingival Inflammation,Plaque Development, Discoloration and Bacterial Plaque Composition Over Six Months. Completed NCT01317446 Phase 4 amine fluoride/stannous fluoride
24 The Clinical Investigation of Colgate Total Toothpaste as Compared to Parodontax Toothpaste and Colgate Cavity Protection Toothpaste in Controlling Established Plaque and Gingivitis. (A Six Month Study) Completed NCT02080273 Phase 4 Colgate Cavity Protection toothpaste;Colgate Total toothpaste;Parodontax toothpaste
25 Effects of Cetylpyridium Chloride (CPC) Based Chewing Gum Plus Tooth Brushing on Plaque Formation and Gingivitis: a Randomized, Double-Blind, Crossover, Placebo-controlled Clinical Trial Completed NCT03219840 Phase 4 CPC;Placebo
26 Effects Of Chlorhexidine Mouthrinse On Peridontopathogens: A Randomized, Placebo-Controlled Study Completed NCT01213550 Phase 4 Chlorhexidine gluconate;Placebo mouthrinse
27 Clinical Efficacy and Patient Acceptance of Metal and Metal-Free Interdental Brushes: A Controlled Prospective Randomized Study Completed NCT01593540 Phase 4
28 Effects of Two Sugar Substituted Chewing Gums Plus Tooth Brushing on Different Caries and Gingivitis Related Variables: a Double Blind, Randomized Controlled Clinical Trial Completed NCT01578603 Phase 4
29 The Clinical Investigation of Colgate Total Toothpaste as Compared to Crest Pro-Health Toothpaste and Crest Pro-Health Mouthwash, and Crest Cavity Protection Toothpaste and Crest Fluoride Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Completed NCT02360995 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride toothpaste;Fluoride Mouthwash;cetylpyridinium chloride Mouthwash
30 Clinical Efficacy in Reducing Established Dental Plaque and Gingivitis of a Toothpaste Containing 0.3% Triclosan, 2% Copolymer / Sodium Fluoride and a Manual Toothbrush as Compared to an Oral Hygiene Multi-component Regimen Encompassing the Use of a Manual Toothbrush, a Toothpaste Containing Stannous Fluoride / Sodium Hexametaphosphate and a Mouthwash Containing 0.07% Cetylpyridinium Chloride Completed NCT02366689 Phase 4 Triclosan/fluoride toothpaste;stannous fluoride toothpaste;fluoride only toothpaste;Cetylpyridinium chloride mouthwash;Fluoride only mouthwash
31 Randomized, Examiner Blind, Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After 3 Weeks Use Completed NCT04050722 Phase 4 Sensodyne Repair and Protect;Colgate Cavity Protection
32 Impact of Oral Hygiene Gels on Peri-implant Mucositis Completed NCT03243591 Phase 4
33 Influence of Pre-procedural Oral Rinse in the Induced Bacteremia by Periodontal Instrumentation: a Randomized Clinical Trial Completed NCT02215473 Phase 4 Chlorhexidine gluconate mouth rinse
34 Evaluation of Mechanical-chemical Gingival Therapy in Diabetic, Obese or Diabese Subjects: Quantitative and Qualitative Analysis of Local and General Aspects. Completed NCT02123563 Phase 4
35 Effectiveness of Metronidazole Gel and Mobile Telephone Short- Message Service Reminders on Gingivitis in Orthodontic Patients: A Randomized Controlled Trial Completed NCT03508999 Phase 4 Metronidazole gel
36 Four Weeks Clinical Efficacy of an Ethyl Lauroyl Arginate HCL (LAE) Mouth Rinse: Effect on Gingivitis Completed NCT02065414 Phase 4
37 The Plaque- and Gingivitis Inhibiting Capacity of a Commercially Available Mouthwash Containing Essential Oils and Ethyl Lauroyl Arginate: A Parallel, Split-mouth, Double Blind, Randomized, Placebo-controlled Clinical Study Completed NCT02884817 Phase 4 Experimental: essential oils and ELA
38 A Multicenter, Randomized, Examiner Blinded Study of Photoactivated Disinfection With Scaling and Root Planing in the Treatment of Chronic Periodontitis Completed NCT00297518 Phase 4
39 Single Blind, Randomized, Active-controlled Comparative Clinical Trial to Evaluate Clinical Efficacy and Safety Following the Application for 4 Weeks of Bio Mineral Toothpaste in Patients With Mild Periodontitis Completed NCT01548469 Phase 4
40 Prospective Double-Blind Randomized Controlled Clinical Trial in the Gingivitis Prevention With an Oligomeric Proanthocyanidins Nutritional Supplement Completed NCT02515929 Phase 4
41 Aloe Vera and Chlorhexidine as Preventive Oral Antiseptics Against the Appearance of Traumatic Oral Ulcers in Patients With Fixed Orthodontics: a Randomized Clinical Trial Completed NCT03633292 Phase 4 Antiseptic clorhexidine gel (Lacer, Barcelona, Spain);Master formula of aloe vera gel 80%
42 Interaction Chlorhexidine-fluoride - a 4-day and 6-week Randomised Clinical Mouthrinse Study Completed NCT02935322 Phase 4 0.12 % chlorhexidine + 0.2 % NaF mouthrinse;0.2 % NaF mouthrinse;0.12% chlorhexidine
43 Effect of Emdogain on Wound Healing After Gingival Recession Coverage Using Connective Tissue Graft: A Pilot Study Completed NCT02230787 Phase 4
44 Effect of Probiotic on the Plaque pH. A Randomized Double Blind Interventional Study Completed NCT01601145 Phase 4
45 Minimally Invasive Treatment for Papillae Deficiencies in Esthetic Zone Using Hyaluronic Acid Completed NCT02876276 Phase 4
46 Clinical Performance of Two 0.2% Chlorhexidine Mouth Rinses After Periodontal Surgery. A Blinded, Intra-individual Cross-over Clinical Trial Recruiting NCT04223076 Phase 4 Chlorhexidine 0.2%, Corsodyl;Chlorhexidine 0.2%, Curasept
47 The Effect of Freeze-Dried Probiotic Sachets Versus Fermented Dairy Product (Yogurt) on Gingival Bleeding on Brushing in Adolescents (12-15) Years Old : A Randomized Clinical Pilot Study Recruiting NCT03640065 Phase 4 freeze-dried probiotic sachets
48 A Randomized, Controlled Clinical Study to Evaluate the Efficacy of a Range of Dental/Denture Products for Improved Oral Health, Compared to Existing Oral Hygiene, in a Population of Partial Denture Wearers With Generalized Mild-moderate Plaque-induced Gingivitis Not yet recruiting NCT04290624 Phase 4
49 A Comparison of Three Different Modalities in Improving Oral Hygiene in Adult Orthodontic Patients - A Randomized Controlled Trial Not yet recruiting NCT04386421 Phase 4 Plaque disclosing tablets
50 Clinical Evidence Efficacy of a Mouthwash Containing Propolis for the Control of Plaque and Gingivitis: Phase III, Randomized, Double-blind Comparison With Mouthwash Chlorhexidine Base. Unknown status NCT01750801 Phase 3 Propolis;chlorhexidine

Search NIH Clinical Center for Gingivitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


carbamide peroxide

Cochrane evidence based reviews: gingivitis

Genetic Tests for Gingivitis

Genetic tests related to Gingivitis:

# Genetic test Affiliating Genes
1 Gingivitis 29

Anatomical Context for Gingivitis

MalaCards organs/tissues related to Gingivitis:

40
Testes, Bone, Neutrophil, Heart, T Cells, Endothelial, Liver

Publications for Gingivitis

Articles related to Gingivitis:

(show top 50) (show all 7468)
# Title Authors PMID Year
1
Changes in gingival crevicular fluid inflammatory mediator levels during the induction and resolution of experimental gingivitis in humans. 61 54
20447255 2010
2
Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods. 61 54
19627514 2010
3
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease. 54 61
18752566 2009
4
Expression and regulation of the NALP3 inflammasome complex in periodontal diseases. 54 61
19664151 2009
5
Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease. 54 61
19656031 2009
6
Up-regulation of the endoplasmic reticulum stress-response in periodontal disease. 54 61
19109937 2009
7
Drop in transforming growth factor-alpha and osteoprotegerin level in gingival crevicular fluid from patients with gingivitis. 61 54
19591043 2009
8
Lactoferrin in Gingival Crevicular Fluid and Peripheral Blood during Experimental Gingivitis. 61 54
19262727 2009
9
Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease. 54 61
18588867 2008
10
The evaluation of cystatin C, IL-1beta, and TNF-alpha levels in total saliva and gingival crevicular fluid from 11- to 16-year-old children. 54 61
18454664 2008
11
Biomarkers of periodontitis in oral fluids. 61 54
18403884 2008
12
The relationship between periodontal status and alkaline phosphatase levels in gingival crevicular fluid in men with hypergonadotropic hypogonadism. 54 61
18306472 2008
13
Screening for periodontitis in pregnant women with salivary enzymes. 54 61
18226127 2008
14
Dental biofilm, gingivitis and interleukin-1 adjacent to approximal sites of a bonded ceramic. 54 61
17941884 2007
15
Differential expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin mRNA in periodontal diseases. 61 54
17559623 2007
16
Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio. 61 54
17355365 2007
17
Levels of metalloproteinase-2 and -9 and tissue inhibitor of matrix metalloproteinase-1 in gingival crevicular fluid of patients with periodontitis, gingivitis, and healthy gingiva. 61 54
17334003 2007
18
The associations between gingival crevice fluid matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and periodontitis in human immunodeficiency virus-positive patients. 54 61
17076772 2006
19
Gingival crevicular fluid matrix metalloproteinase-13 levels and molecular forms in various types of periodontal diseases. 61 54
17054770 2006
20
Interleukin-1beta, interleukin-12 and interleukin-18 levels in gingival fluid and serum of patients with gingivitis and periodontitis. 54 61
16842511 2006
21
Interleukin-1 levels in gingival crevicular fluid adjacent to restorations of calcium aluminate cement and resin composite. 54 61
15842260 2005
22
Plasminogen activator system in smokers and non-smokers with and without periodontal disease. 61 54
15811061 2005
23
Matrix metalloproteinase-1 and -8 in gingival crevicular fluid during orthodontic tooth movement: a pilot study during 1 month of follow-up after fixed appliance activation. 54 61
15817630 2005
24
Secretory function of neutrophilic leukocytes of the patients with periodontal diseases. 61 54
16340274 2005
25
Plasminogen activators and plasminogen activator inhibitors in gingival crevicular fluid of cyclosporin A-treated patients. 54 61
15191592 2004
26
[IL-1beta and PGE2 production in whole blood and gingival fluid in women with periodontitis and preterm low birth weight]. 54 61
15524408 2004
27
Interleukin-11 and IL-17 and the pathogenesis of periodontal disease. 54 61
15025215 2004
28
Effect of smoking on gingival crevicular fluid cytokine profile during experimental gingivitis. 54 61
14761123 2003
29
Salivary cystatin activity and cystatin C in experimental gingivitis in non-smokers. 54 61
14710768 2003
30
Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis. 61 54
12828663 2003
31
Effects of plaque, psychological stress and gender on crevicular Il-1beta and Il-1ra secretion. 54 61
12631182 2003
32
Porphyromonas gingivalis antigen preferentially stimulates T cells to express IL-17 but not receptor activator of NF-kappaB ligand in vitro. 61 54
12588456 2003
33
Crevicular fluid levels of interleukin-1alpha and interleukin-1beta during experimental gingivitis in young and old adults. 54 61
12670080 2002
34
Effect of low-power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts. 54 61
12355572 2002
35
Relation between alkaline phosphatase in gingigval crevicular fluid of implant teeth and the curing result. 61 54
12903766 2001
36
Salivary cystatin activity and cystatin C in natural and experimental gingivitis in smokers and non-smokers. 61 54
11686817 2001
37
Concentration of interleukin-1beta and neutrophil elastase activity in gingival crevicular fluid during experimental gingivitis. 61 54
11350521 2001
38
Matrix metalloproteinases (MMP-8 and -9) and neutrophil elastase in gingival crevicular fluid of cyclosporin-treated patients. 54 61
11327063 2001
39
[Relation between alkaline phosphatase in gingival crevicular fluid of implant and the curing result]. 61 54
12905820 2001
40
Microassay for the detection of elastase activity in the gingival crevice. 61 54
11142664 2001
41
Increasing expression of tissue plasminogen activator and plasminogen activator inhibitor type 2 in dog gingival tissues with progressive inflammation. 61 54
11163592 2001
42
Detection of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor 2(PAI-2) in gingival crevicular fluid from healthy, gingivitis and periodontitis patients. 61 54
10743860 2000
43
Relationship of surface epithelium concentrations of IL-1 alpha and IL-1 beta to clinical inflammation during experimental gingivitis. 54 61
10949833 2000
44
Activities of lysozyme and salivary peroxidase in unstimulated whole saliva in relation to plaque and gingivitis scores in healthy young males. 61 54
10803124 1999
45
Activation of neutrophil collagenase in periodontitis. 61 54
10225890 1999
46
PGE2, IL-1 beta, and TNF-alpha responses in diabetics as modifiers of periodontal disease expression. 61 54
9722689 1998
47
Proinflammatory cytokines production and PMN-elastase release from activated PMN cells in the periodontal disease. 61 54
11845441 1998
48
Activity and inhibition of elastase in GCF. 54 61
9696251 1998
49
Salivary anti-hsp65 antibodies as a diagnostic marker for gingivitis and a possible link to atherosclerosis. 54 61
9363905 1997
50
Prostaglandin E2 level in gingival crevicular fluid from patients with Down syndrome. 61 54
9176657 1997

Variations for Gingivitis

Expression for Gingivitis

Search GEO for disease gene expression data for Gingivitis.

Pathways for Gingivitis

Pathways related to Gingivitis according to GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 TNF TLR2 TIMP1 MMP9 MMP8 MMP1
2
Show member pathways
13.59 TNF TIMP1 IL6 IL4 IL1B IL1A
3
Show member pathways
13.5 TNF TLR2 TIMP1 IL6 IL4 IL1B
4
Show member pathways
13.45 TNF TIMP1 MMP9 MMP1 IL6 IL4
5
Show member pathways
13.39 TNF TIMP1 IL6 IL4 IL1B IL1A
6
Show member pathways
13.15 TNF TLR2 MMP9 IL6 IL1B IL10
7
Show member pathways
12.96 TNF IL6 IL4 IL1B IL1A IL10
8
Show member pathways
12.91 TNF TLR2 IL6 IL1B IL1A CXCL8
9
Show member pathways
12.85 TIMP1 MMP9 MMP8 MMP1 ELANE CTSG
10
Show member pathways
12.83 TNF TLR2 IL6 IL1B IL1A CXCL8
11
Show member pathways
12.8 TNF TLR2 TIMP1 IL6 IL1B IL1A
12
Show member pathways
12.71 TNF TLR2 IL6 IL4 IL1B IL1A
13
Show member pathways
12.7 TNF TLR2 IL6 IL4 IL1B IL1A
14
Show member pathways
12.67 TNF TIMP1 IL6 IL1B IL10
15 12.65 TNF TLR2 IL4 IL1B IL10
16
Show member pathways
12.44 TNF PLAT IL6 IL4 IL1B
17
Show member pathways
12.44 TLR2 LTF ELANE DEFB4A CTSG
18
Show member pathways
12.42 TNF IL6 IL1B IL1A CXCL8
19 12.41 TNF TLR2 IL6 IL1B CXCL8
20
Show member pathways
12.39 TNF IL6 IL10 CXCL8
21
Show member pathways
12.39 TNF TLR2 IL4 IL1B IL1A IL10
22 12.37 PLAT MMP9 IL6 ELANE CXCL8
23
Show member pathways
12.37 TNF TIMP1 IL6 IL4 IL1B IL1A
24
Show member pathways
12.36 TNF TLR2 IL6 IL1A CXCL8
25 12.34 TNF IL6 IL1B DEFB4A CXCL8
26 12.34 TNF TLR2 IL6 IL1B IL1A IL10
27 12.33 TNF IL6 IL1B CXCL8
28 12.3 TNF TLR2 MMP9 MMP1 IL6
29
Show member pathways
12.3 TNF TLR2 IL6 IL4 IL1B DEFB4A
30 12.29 TNF IL6 IL1B IL1A IL10 CXCL8
31
Show member pathways
12.28 TNF IL6 IL1B IL10
32 12.21 TNF PLAT MMP9 IL1B IL1A
33 12.14 TNF IL6 IL1B IL10 CXCL8
34
Show member pathways
12.14 TNF TLR2 MMP9 MMP1 IL6 IL4
35 12.12 TNF MMP9 IL6 IL4 IL1B IL1A
36 12.09 TNF IL6 IL4 IL10
37 12.08 TNF MMP9 IL6 IL1B
38
Show member pathways
12.08 TNF TLR2 IL6 IL1B IL10
39 12.07 SERPINB2 PLAT IL6 IL1B IL1A CXCL8
40 12.05 TNF IL6 IL1B IL1A CXCL8
41 12.04 TNF IL6 IL4 IL1B IL1A
42 12.01 TNF TLR2 IL6 IL1B IL10 CXCL8
43
Show member pathways
11.98 TLR2 IL6 IL4 IL1B
44
Show member pathways
11.97 TNF TIMP1 MMP9 MMP8 MMP1 ELANE
45 11.92 MMP1 IL6 IL4 CXCL8
46 11.92 TNF TLR2 MMP1 IL6 IL1B IL1A
47 11.9 TNF IL4 IL1B IL10
48 11.88 TNF IL6 IL1B IL1A IL10 CXCL8
49 11.86 TNF IL6 IL1B IL10
50
Show member pathways
11.81 TNF IL4 CXCL8

GO Terms for Gingivitis

Cellular components related to Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 TNF TIMP1 SERPINB2 PLAT MMP9 MMP8
2 cell surface GO:0009986 9.73 TNF TLR2 PLAT LTF ELANE CTSG
3 collagen-containing extracellular matrix GO:0062023 9.72 PLAT MMP9 MMP8 ELANE CTSG
4 extracellular region GO:0005576 9.6 TNF TIMP1 SERPINB2 PLAT MMP9 MMP8
5 specific granule lumen GO:0035580 9.58 MMP8 LTF ELANE
6 secretory granule GO:0030141 9.55 PLAT LTF IL1B ELANE CTSG
7 tertiary granule lumen GO:1904724 9.54 MMP9 MMP8 LTF

Biological processes related to Gingivitis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.28 TNF TLR2 IL6 IL4 IL1B IL1A
2 proteolysis GO:0006508 10.14 PLAT MMP9 MMP8 MMP1 LTF ELANE
3 negative regulation of cell proliferation GO:0008285 10.11 TLR2 IL6 IL1B IL1A IL10 CXCL8
4 inflammatory response GO:0006954 10.08 TNF TLR2 IL6 IL1B IL1A CXCL8
5 negative regulation of apoptotic process GO:0043066 10.08 TIMP1 SERPINB2 MMP9 LTF IL6 IL4
6 positive regulation of gene expression GO:0010628 10.04 TNF TLR2 MMP8 IL6 IL4 IL1B
7 leukocyte migration GO:0050900 10.03 TNF MMP1 IL1B ELANE
8 cellular protein metabolic process GO:0044267 10.03 TIMP1 MMP1 LTF IL6 CTSG
9 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.02 TNF LTF IL1B IL1A
10 neutrophil degranulation GO:0043312 10.02 TLR2 MMP9 MMP8 LTF GUSB ELANE
11 response to lipopolysaccharide GO:0032496 9.98 TLR2 IL1B IL10 ELANE CTSG
12 positive regulation of DNA-binding transcription factor activity GO:0051091 9.96 TNF IL6 IL1B IL10
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 TNF TLR2 LTF IL6 IL1B
14 defense response to bacterium GO:0042742 9.95 TNF LTF LPO IL10 ELANE DEFB4A
15 defense response to Gram-negative bacterium GO:0050829 9.92 LTF IL6 DEFB4A CTSG
16 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 TNF IL6 IL4
17 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.91 LTF DEFB4A CXCL8
18 response to glucocorticoid GO:0051384 9.91 TNF IL6 IL10
19 positive regulation of T cell proliferation GO:0042102 9.9 IL6 IL4 IL1B
20 positive regulation of smooth muscle cell proliferation GO:0048661 9.9 TNF IL6 ELANE
21 humoral immune response GO:0006959 9.9 TNF LTF IL6
22 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.89 TNF MMP9 IL10
23 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TNF MMP8 IL1B
24 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 TNF TLR2 MMP8 IL1B
25 collagen catabolic process GO:0030574 9.87 MMP9 MMP8 MMP1
26 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.86 TNF IL1B IL1A
27 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.86 IL4 IL1B IL1A
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 TNF TLR2 IL1B
29 antimicrobial humoral response GO:0019730 9.85 LTF ELANE DEFB4A CTSG
30 positive regulation of cytokine secretion GO:0050715 9.84 TNF IL1A IL10
31 positive regulation of JAK-STAT cascade GO:0046427 9.83 TNF IL6 IL10
32 microglial cell activation GO:0001774 9.83 TNF TLR2 IL4
33 defense response to Gram-positive bacterium GO:0050830 9.83 TNF TLR2 IL6 DEFB4A CTSG
34 positive regulation of interleukin-8 production GO:0032757 9.82 TNF TLR2 IL1B
35 positive regulation of vascular endothelial growth factor production GO:0010575 9.82 IL6 IL1B IL1A
36 negative regulation of neurogenesis GO:0050768 9.81 TNF IL6 IL1B
37 cellular response to lipopolysaccharide GO:0071222 9.8 TNF IL6 IL1B IL1A IL10 CXCL8
38 positive regulation of chemokine production GO:0032722 9.79 TNF TLR2 IL6
39 positive regulation of glial cell proliferation GO:0060252 9.79 TNF IL6 IL1B
40 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.77 TNF IL1B IL10
41 positive regulation of interleukin-6 production GO:0032755 9.77 TNF TLR2 MMP8 IL6 IL1B
42 positive regulation of interleukin-6 secretion GO:2000778 9.76 TNF TLR2 IL1B IL1A
43 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.74 IL4 IL10
44 positive regulation of MHC class II biosynthetic process GO:0045348 9.74 IL4 IL10
45 negative regulation of lipid storage GO:0010888 9.74 TNF IL6
46 positive regulation of chemokine biosynthetic process GO:0045080 9.74 TNF IL4 IL1B
47 regulation of establishment of endothelial barrier GO:1903140 9.73 TNF IL1B
48 endothelial cell apoptotic process GO:0072577 9.73 TNF IL10
49 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.73 TIMP1 IL10
50 ectopic germ cell programmed cell death GO:0035234 9.72 IL1B IL1A

Molecular functions related to Gingivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.97 TLR2 PLAT MMP9 MMP8 MMP1 LTF
2 growth factor activity GO:0008083 9.71 TIMP1 IL6 IL4 IL10
3 peptidase activity GO:0008233 9.7 PLAT MMP9 MMP8 MMP1 LTF ELANE
4 serine-type peptidase activity GO:0008236 9.67 PLAT LTF ELANE CTSG
5 endopeptidase activity GO:0004175 9.56 MMP9 MMP8 MMP1 ELANE
6 serine-type endopeptidase activity GO:0004252 9.5 PLAT MMP9 MMP8 MMP1 LTF ELANE
7 cytokine activity GO:0005125 9.23 TNF TIMP1 IL6 IL4 IL1B IL1A

Sources for Gingivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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