MCID: GLN002
MIFTS: 42

Glanders

Categories: Endocrine diseases, Infectious diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Glanders

MalaCards integrated aliases for Glanders:

Name: Glanders 12 54 3 45 15 17 74
Infection Due to Pseudomonas Mallei 12
Burkholderia Mallei Infection 54
Burkholderia Mallei 54
Farcy Pipes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13444
ICD9CM 36 024
MeSH 45 D005896
NCIt 51 C34638
SNOMED-CT 69 35322000 4639008
ICD10 34 A24.0
UMLS 74 C0017589

Summaries for Glanders

Disease Ontology : 12 A primary bacterial infectious disease that results in septicemic infection, has material basis in Burkholderia mallei, which is transmitted by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs.

MalaCards based summary : Glanders, also known as infection due to pseudomonas mallei, is related to melioidosis and campylobacteriosis. An important gene associated with Glanders is HCFC1 (Host Cell Factor C1), and among its related pathways/superpathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and Microglia Activation During Neuroinflammation: Overview. The drugs Emodepside and Melphalan have been mentioned in the context of this disorder. Affiliated tissues include lung, eye and testes, and related phenotypes are cellular and liver/biliary system

CDC : 3 Learn where glanders is found around the world.

Wikipedia : 77 Glanders is an infectious disease that occurs primarily in horses, mules, and donkeys. It can be... more...

Related Diseases for Glanders

Diseases related to Glanders via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 melioidosis 11.2
2 campylobacteriosis 10.0 HCFC1 TLR4
3 brucellosis 10.0
4 q fever 10.0
5 relapsing fever 10.0
6 tick-borne relapsing fever 10.0
7 severe acute respiratory syndrome 10.0
8 actinomycosis 10.0
9 pemphigus 10.0
10 lymphangitis 10.0
11 pemphigus vegetans 10.0
12 pelvic inflammatory disease 9.9 HSPD1 TLR4
13 primary bacterial infectious disease 9.9 HSPD1 TLR4
14 bacterial infectious disease 9.9 HSPD1 TLR4
15 chlamydia 9.9 HSPD1 TLR4
16 periodontal disease 9.8 HSPD1 TLR4
17 mycobacterium tuberculosis 1 9.8 HSPD1 TLR4
18 arteriosclerosis 9.7 HSPD1 TLR4
19 leukodystrophy 9.7 HSPD1 PSAP

Graphical network of the top 20 diseases related to Glanders:



Diseases related to Glanders

Symptoms & Phenotypes for Glanders

MGI Mouse Phenotypes related to Glanders:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.43 GADD45B HCFC1 HSPD1 LRP5 PSAP TLR4
2 liver/biliary system MP:0005370 8.92 HCFC1 LRP5 PSAP TLR4

Drugs & Therapeutics for Glanders

Drugs for Glanders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Emodepside Investigational, Vet_approved Phase 4 155030-63-0
2
Melphalan Approved Phase 1 148-82-3 460612 4053
3 Anesthetics Phase 1,Not Applicable
4 Alkylating Agents Phase 1
5 Immunologic Factors Phase 1
6 Immunosuppressive Agents Phase 1
7 Antineoplastic Agents, Alkylating Phase 1
8 Liver Extracts Phase 1
9
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
10
Chloroprocaine Approved 133-16-4 8612
11
Imidacloprid Vet_approved 105827-78-9 86418
12 Central Nervous System Depressants
13 Anesthetics, Local
14 Peripheral Nervous System Agents
15 Analgesics
16 Anti-Inflammatory Agents
17 Analgesics, Non-Narcotic
18 Anti-Inflammatory Agents, Non-Steroidal
19 Antirheumatic Agents

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Glaucoma Treatment by Cyclo-coagulation Using High Intensity Focused Ultrasound (HIFU) Completed NCT01592955 Phase 4
2 Spinal Magnetic Stimulation in Neuropathic Pain Completed NCT00443469 Phase 3
3 Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods) Unknown status NCT02591901 Phase 2 Uro vaxom
4 Hypofractionated Radiotherapy (16/2) for the Palliation of Complicated Bone Metastases in Patients With KPS Completed NCT02376322 Phase 2
5 Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases Active, not recruiting NCT03028337 Phase 2
6 Intra-arterial Chemotherapy for Spinal Metastases Completed NCT01637766 Phase 1 Melphalan (intra-arterial infusion)
7 Trial for Salvage Re-Irradiation of Metastatic Spine Lesions Using Single-Fraction Stereotactic Radiosurgery Recruiting NCT02278744 Phase 1
8 High Dose Rate Brachyablation of Primary Liver Lesions Recruiting NCT02893982 Phase 1
9 Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated Disc Unknown status NCT00927056 Not Applicable
10 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328 Not Applicable
11 Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal Anaesthesia Completed NCT02067806 Spinal administration of chloroprocaine
12 The Effect of Spinal Flexion in the Lateral Decubitus Position on the Unilaterality During Spinal Anesthesia Completed NCT01321684 Not Applicable
13 Characteristics of Back Pain Attendances at ED Completed NCT03762174
14 Characteristics of Back Pain Callers Completed NCT03474068
15 Neurologic Complications in Spinal Deformity Surgery Completed NCT01305343
16 Glaucoma Treatment by Circular Cyclocoagulation Using High Intensity Focused Ultrasound With the EYEOP Medical Device Completed NCT01338467 Not Applicable
17 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
18 Electroacupuncture for Urinary Function of Patients With Chronic Urinary Retention (CUR) Secondary to Lower Motor Neuron Lesion Recruiting NCT03662906 Not Applicable
19 A Trial to Improve Quality of Life With Stereotactic Body Radiotherapy for Patients With Painful Bone Metastases Recruiting NCT03831243 Not Applicable
20 Implementation of a "Remission" Consultation in the Management of Patients Treated for Localized Breast Cancer Recruiting NCT02740491
21 BLB Study Back or Leg Pain and Bladder Symptoms Study Active, not recruiting NCT03325374
22 Stereotactic Body Radiotherapy Boost After Palliative Radiotherapy for Spinal Cord Compression Not yet recruiting NCT03529708 Not Applicable
23 Efficacy of Acupuncture for Lumbar Spinal Stenosis Not yet recruiting NCT03784729 Not Applicable
24 Post-void Bladder Scanning in Acute Cauda Equina Syndrome Withdrawn NCT02806167 Not Applicable

Search NIH Clinical Center for Glanders

Cochrane evidence based reviews: glanders

Genetic Tests for Glanders

Anatomical Context for Glanders

MalaCards organs/tissues related to Glanders:

42
Lung, Eye, Testes, Liver, Bone, Breast, Spinal Cord

Publications for Glanders

Articles related to Glanders:

(show top 50) (show all 162)
# Title Authors Year
1
A real-time loop mediated isothermal amplification assay for molecular detection of Burkholderia mallei, the aetiological agent of a zoonotic and re-emerging disease glanders. ( 30958991 )
2019
2
Development of Rose Bengal test against mallein test for rapid diagnosis of equine glanders. ( 31041722 )
2019
3
Evaluation of the comparative accuracy of the complement fixation test, Western blot and five enzyme-linked immunosorbent assays for serodiagnosis of glanders. ( 30951554 )
2019
4
Improvement of recombinant-truncated Burkholderia motility protein A (BimA)-based indirect ELISA for equine glanders. ( 30303469 )
2018
5
Outer Membrane Vesicle Vaccines from Biosafe Surrogates Prevent Acute Lethal Glanders in Mice. ( 29320408 )
2018
6
Use of Immunohistochemistry to Demonstrate In Vivo Expression of the Burkholderia mallei Virulence Factor BpaB During Experimental Glanders. ( 29145795 )
2018
7
Vaccines for the Prevention of Melioidosis and Glanders. ( 29242769 )
2017
8
A Burkholderia pseudomallei Outer Membrane Vesicle Vaccine Provides Cross Protection against Inhalational Glanders in Mice and Non-Human Primates. ( 29232837 )
2017
9
Seroprevalence and risk factors of glanders in working equines - Findings of a cross-sectional study in Punjab province of Pakistan. ( 28760480 )
2017
10
Identification of a new diagnostic antigen for glanders using immunoproteome analysis. ( 28750864 )
2017
11
From glanders to globulins: A study in comparative medicine. ( 26307410 )
2017
12
Glanders and history. ( 27339929 )
2016
13
Harmonising diagnostic testing for glanders in equids. ( 27313253 )
2016
14
Glanders and the risk for its introduction through the international movement of horses. ( 27288893 )
2016
15
Burkholderia mallei CLH001 Attenuated Vaccine Strain Is Immunogenic and Protects against Acute Respiratory Glanders. ( 27271739 )
2016
16
Interlaboratory ring trial to evaluate CFT proficiency of European laboratories for diagnosis of glanders in equids. ( 27122499 )
2016
17
Melioidosis and glanders modulation of the innate immune system: barriers to current and future vaccine approaches. ( 27010618 )
2016
18
Phenotypic Characterization of a Novel Virulence-Factor Deletion Strain of Burkholderia mallei That Provides Partial Protection against Inhalational Glanders in Mice. ( 26955620 )
2016
19
Surveillance focus: glanders. ( 26183359 )
2015
20
Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders. ( 26148026 )
2015
21
Pathological findings and diagnostic implications of a rhesus macaque (Macacca mulatta) model of aerosol exposure to Burkholderia mallei (glanders). ( 25850696 )
2015
22
Efficacy of postexposure therapy against glanders in mice. ( 25645854 )
2015
23
Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine. ( 25533326 )
2015
24
Effect of incubation temperature on the diagnostic sensitivity of the glanders complement fixation test. ( 25812210 )
2014
25
Comparative experimental subcutaneous glanders and melioidosis in the common marmoset (Callithrix jacchus). ( 25477002 )
2014
26
Genotyping of Burkholderia mallei from an outbreak of glanders in Bahrain suggests multiple introduction events. ( 25255232 )
2014
27
Optimization and validation of indirect ELISA using truncated TssB protein for the serodiagnosis of glanders amongst equines. ( 24672321 )
2014
28
Assessment of the effectiveness of the PPD-mallein produced in Brazil for diagnosing glanders in mules. ( 24159303 )
2013
29
Glanders: an overview of infection in humans. ( 24004906 )
2013
30
From glanders to Hendra virus: 125 years of equine infectious diseases. ( 23997164 )
2013
31
Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glanders. ( 23517714 )
2013
32
Glanders in animals: a review on epidemiology, clinical presentation, diagnosis and countermeasures. ( 22630609 )
2013
33
Development of novel O-polysaccharide based glycoconjugates for immunization against glanders. ( 23205347 )
2012
34
Effectiveness of an antimicrobial treatment scheme in a confined glanders outbreak. ( 23134717 )
2012
35
Development and validation of a method for purification of mallein for the diagnosis of glanders in equines. ( 22937975 )
2012
36
Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders. ( 22912938 )
2012
37
Glanders outbreak at Tehran Zoo, Iran. ( 22783454 )
2012
38
Emergence and re-emergence of glanders in India: a description of outbreaks from 2006 to 2011. ( 22718333 )
2012
39
Evaluation of recombinant proteins of Burkholderia mallei for serodiagnosis of glanders. ( 22695165 )
2012
40
Recent progress in melioidosis and glanders. ( 22529846 )
2012
41
Performance of complement fixation test and confirmatory immunoblot as two-cascade testing approach for serodiagnosis of glanders in an endemic region of South East Asia. ( 22515029 )
2012
42
Humoral immune responses in a human case of glanders. ( 22398248 )
2012
43
Development of hydrolysis probe-based real-time PCR for identification of virulent gene targets of Burkholderia pseudomallei and B. mallei--a retrospective study on archival cases of service members with melioidosis and glanders. ( 22360070 )
2012
44
Construction and molecular characterization of mouse single-chain variable fragment antibodies against Burkholderia mallei and Burkholderia pseudomallei. ( 21172353 )
2011
45
Outer membrane proteome of Burkholderia pseudomallei and Burkholderia mallei from diverse growth conditions. ( 21391724 )
2011
46
Diagnostic assays for glanders. ( 22184353 )
2011
47
Protective antigens against glanders identified by expression library immunization. ( 22125550 )
2011
48
Comparative evaluation of three commercially available complement fixation test antigens for the diagnosis of glanders. ( 21896565 )
2011
49
Use of a recombinant burkholderia intracellular motility a protein for immunodiagnosis of glanders. ( 21752949 )
2011
50
Use of a Western blot technique for the serodiagnosis of glanders. ( 21247488 )
2011

Variations for Glanders

Expression for Glanders

Search GEO for disease gene expression data for Glanders.

Pathways for Glanders

GO Terms for Glanders

Cellular components related to Glanders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide receptor complex GO:0046696 8.62 HSPD1 TLR4

Biological processes related to Glanders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion organization GO:0007005 9.48 HCFC1 HSPD1
2 positive regulation of JNK cascade GO:0046330 9.46 GADD45B TLR4
3 positive regulation of interleukin-6 production GO:0032755 9.4 HSPD1 TLR4
4 positive regulation of interferon-gamma production GO:0032729 9.37 HSPD1 TLR4
5 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.32 HSPD1 TLR4
6 positive regulation of interleukin-12 production GO:0032735 9.26 HSPD1 TLR4
7 positive regulation of interleukin-10 production GO:0032733 9.16 HSPD1 TLR4
8 positive regulation of inflammatory response GO:0050729 9.13 TLR4
9 positive regulation of macrophage activation GO:0043032 8.96 HSPD1 TLR4
10 positive regulation of interferon-alpha production GO:0032727 8.62 HSPD1 TLR4

Molecular functions related to Glanders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 8.62 HSPD1 TLR4

Sources for Glanders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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