MCID: GLN002
MIFTS: 35

Glanders

Categories: Endocrine diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Glanders

MalaCards integrated aliases for Glanders:

Name: Glanders 12 52 3 43 15 17 71 32
Burkholderia Mallei 52 3
Infection Due to Pseudomonas Mallei 12
Burkholderia Mallei Infection 52
Farcy Pipes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13444
ICD9CM 34 024
MeSH 43 D005896
NCIt 49 C34638
SNOMED-CT 67 4639008
ICD10 32 A24.0
UMLS 71 C0017589

Summaries for Glanders

Disease Ontology : 12 A primary bacterial infectious disease that results in septicemic infection, has material basis in Burkholderia mallei, which is transmitted by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs.

MalaCards based summary : Glanders, also known as burkholderia mallei, is related to melioidosis and pneumonia. An important gene associated with Glanders is WARS1 (Tryptophanyl-TRNA Synthetase 1), and among its related pathways/superpathways are IL27-mediated signaling events and Th17 Differentiation. Affiliated tissues include lung, eye and testes.

CDC : 3 Glanders is an infectious disease that is caused by the bacterium Burkholderia mallei. While people can get the disease, glanders is primarily a disease affecting horses. It also affects donkeys and mules and can be naturally contracted by other mammals such as goats, dogs, and cats.

Wikipedia : 74 Glanders is a contagious zoonotic infectious disease that occurs primarily in horses, mules, and... more...

Related Diseases for Glanders

Diseases related to Glanders via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 melioidosis 32.2 TLR5 TLR4 SAMM50
2 pneumonia 30.1 TLR5 TLR4 HSPD1 CD8A
3 tularemia 29.9 TLR4 HSPD1 CD8A CD4
4 bacterial infectious disease 29.6 TLR5 TLR4 HSPD1 CD8A CD4
5 plague 29.4 WARS1 TLR5 TLR4 CD8A CD4
6 salmonellosis 29.3 TLR5 TLR4 CD8A CD4
7 epidemic typhus 28.8 WARS1 TLR5 TLR4 HSPD1 CD8A CD4
8 carrion's disease 10.5 WARS1 HSPD1
9 trench fever 10.5 WARS1 HSPD1
10 endemic typhus 10.4 WARS1 HSPD1
11 conjunctivitis 10.3
12 lung disease 10.3
13 cytokine deficiency 10.3
14 bubonic plague 10.2 WARS1 TLR4
15 brucellosis 10.2
16 anthrax disease 10.2
17 opportunistic bacterial infectious disease 10.2 HSPD1 CD4
18 nocardiosis 10.2 HSPD1 CD4
19 chancroid 10.2 HSPD1 CD4
20 cat-scratch disease 10.2 HSPD1 CD4
21 human monocytic ehrlichiosis 10.1 HSPD1 CD4
22 cervical adenitis 10.1 HSPD1 CD4
23 myd88 deficiency 10.1 TLR5 TLR4
24 legionellosis 10.1 TLR5 TLR4 HSPD1
25 irak4 deficiency 10.1 TLR5 TLR4
26 salpingitis 10.1 HSPD1 CD4
27 bacillary angiomatosis 10.1 WARS1 HSPD1 CD4
28 bartonellosis 10.1 WARS1 HSPD1 CD4
29 cork-handlers' disease 10.0 CD8A CD4
30 toxic shock syndrome 10.0
31 cholera 10.0
32 severe acute respiratory syndrome 10.0
33 pulmonary tuberculosis 10.0
34 tick-borne relapsing fever 10.0
35 relapsing fever 10.0
36 dysentery 10.0
37 allergic hypersensitivity disease 10.0
38 diphtheria 10.0
39 erysipelas 10.0
40 rabies 10.0
41 q fever 10.0
42 granulomatosis with polyangiitis 10.0
43 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
44 severe combined immunodeficiency 10.0
45 prion disease 10.0
46 actinomycosis 10.0
47 pemphigus 10.0
48 lymphangitis 10.0
49 pemphigus vegetans 10.0
50 urethritis 10.0 TLR4 HSPD1 CD4

Graphical network of the top 20 diseases related to Glanders:



Diseases related to Glanders

Symptoms & Phenotypes for Glanders

Drugs & Therapeutics for Glanders

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Use of the Peristeen Bowel Irrigation System for People With Cauda Equina Syndrome Completed NCT01784328

Search NIH Clinical Center for Glanders

Cochrane evidence based reviews: glanders

Genetic Tests for Glanders

Anatomical Context for Glanders

MalaCards organs/tissues related to Glanders:

40
Lung, Eye, Testes, Monocytes, Bone, Spleen, Liver

Publications for Glanders

Articles related to Glanders:

(show top 50) (show all 596)
# Title Authors PMID Year
1
Development of a microsphere-based immunoassay for the serological detection of glanders in equids. 61
32302692 2020
2
ScmR, a Global Regulator of Gene Expression, Quorum Sensing, pH Homeostasis, and Virulence in Burkholderia thailandensis. 61
32312745 2020
3
Serological surveillance and clinical investigation of glanders among indigenous equines in India from 2015 to 2018. 61
31916415 2020
4
A new intrinsic aminoglycoside 6'-N-acetyltransferase subclass, AAC(6')-III, in Burkholderia pseudomallei, Burkholderia mallei and Burkholderia oklahomensis. 61
32016409 2020
5
Sulfonium Acids Loaded onto an Unusual Thiotemplate Assembly Line Construct the Cyclopropanol Warhead of a Burkholderia Virulence Factor. 61
32314848 2020
6
Laser Scanning Confocal Microscopy Was Used to Validate the Presence of Burkholderia Pseudomallei or B. Mallei in Formalin-Fixed Paraffin Embedded Tissues. 61
32365605 2020
7
[Georg von Hofmann-Wellenhof-130 years ago the first victim at the beginning of the investigation of infectious diseases in Austria]. 61
30539319 2020
8
Combinations of early generation antibiotics and antimicrobial peptides are effective against a broad spectrum of bacterial biothreat agents. 61
32050093 2020
9
Synthesis of the Oligosaccharides of Burkholderia pseudomallei and B. mallei Capsular Polysaccharide and Preliminary Immunological Studies of Their Protein Conjugates. 61
31912729 2020
10
Untargeted accurate identification of highly pathogenic bacteria directly from blood culture flasks. 61
31784214 2020
11
Clinical repercussions of Glanders (Burkholderia mallei infection) in a Brazilian child: a case report. 61
32578712 2020
12
The Burkholderia thailandensis Phages ΦE058 and ΦE067 Represent Distinct Prototypes of a New Subgroup of Temperate Burkholderia Myoviruses. 61
32528458 2020
13
A Machine Learning-Based Raman Spectroscopic Assay for the Identification of Burkholderia mallei and Related Species. 61
31835527 2019
14
Emerging role of biologics for the treatment of melioidosis and glanders. 61
31590578 2019
15
Lipopolysaccharides from Different Burkholderia Species with Different Lipid A Structures Induce Toll-Like Receptor 4 Activation and React with Melioidosis Patient Sera. 61
31548320 2019
16
Melioidosis patient serum-reactive synthetic tetrasaccharides bearing the predominant epitopes of Burkholderia pseudomallei and Burkholderia mallei O-antigens. 61
31513223 2019
17
Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human- and Animal-Pathogenic Burkholderia Species. 61
31353766 2019
18
First record of Burkholderia mallei Turkey 10 strain originating from glanderous horses from Brazil. 61
31321739 2019
19
Development of Rose Bengal test against mallein test for rapid diagnosis of equine glanders. 61
31041722 2019
20
Transcriptome analysis of human monocytic cells infected with Burkholderia species and exploration of pentraxin-3 as part of the innate immune response against the organisms. 61
31492148 2019
21
Evaluation of serological responses in horses challenged with Burkholderia pseudomallei using current diagnostic tests for glanders. 61
31599551 2019
22
An in situ high-throughput screen identifies inhibitors of intracellular Burkholderia pseudomallei with therapeutic efficacy. 61
31439817 2019
23
GC-072: A Novel Therapeutic Candidate for Oral Treatment of Melioidosis and Infections Caused by Select Biothreat Pathogens. 61
31548183 2019
24
Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens. 61
31164713 2019
25
A general protein O-glycosylation machinery conserved in Burkholderia species improves bacterial fitness and elicits glycan immunogenicity in humans. 61
31350337 2019
26
Evaluation of Burkholderia mallei ΔtonB Δhcp1 (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis. 61
31306423 2019
27
Spatiotemporal Analysis of Glanders in Brazil. 61
31203979 2019
28
Development of an immunoblotting assay for serodiagnosis of Burkholderia mallei infection: the whole-cell proteome-based paradigm. 61
31523407 2019
29
A real-time loop mediated isothermal amplification assay for molecular detection of Burkholderia mallei, the aetiological agent of a zoonotic and re-emerging disease glanders. 61
30958991 2019
30
A novel selective medium for the isolation of Burkholderia mallei from equine specimens. 61
31064357 2019
31
Burkholderia mallei: The dynamics of networks and disease transmission. 61
30427593 2019
32
Development of a rapid and sensitive recombinase polymerase amplification-lateral flow assay for detection of Burkholderia mallei. 61
30650261 2019
33
An increase in intracellular p62/NBR1 and persistence of Burkholderia mallei and B. pseudomallei in infected mice linked to autophagy deficiency. 61
30569531 2019
34
Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic Burkholderia spp. 61
30602525 2019
35
Rapid detection of Burkholderia pseudomallei with a lateral flow recombinase polymerase amplification assay. 61
31283772 2019
36
[Preparation for state registration of the reagent kit for the detection and differentiation of the DNA of burkholderia «pseudomallei» group.] 61
31012558 2019
37
Burkholderia pseudomallei ΔtonB Δhcp1 Live Attenuated Vaccine Strain Elicits Full Protective Immunity against Aerosolized Melioidosis Infection. 61
30602524 2019
38
[Assessment of the possibility of application in laboratory practice of reagent kit for diagnosis of glanders and melioidosis by real-time polymerase chain reaction.] 61
31747502 2019
39
The potential for an outbreak of glanders in Nepal. 61
31889885 2019
40
Molecular Mechanisms of AhpC in Resistance to Oxidative Stress in Burkholderia thailandensis. 61
31338075 2019
41
Evaluation of the comparative accuracy of the complement fixation test, Western blot and five enzyme-linked immunosorbent assays for serodiagnosis of glanders. 61
30951554 2019
42
Rapid antimicrobial susceptibility testing and β-lactam-induced cell morphology changes of Gram-negative biological threat pathogens by optical screening. 61
30563467 2018
43
Genome rearrangements and selection in multi-chromosome bacteria Burkholderia spp. 61
30587126 2018
44
Polysaccharides from Burkholderia species as targets for vaccine development, immunomodulation and chemical synthesis. 61
30023998 2018
45
High-resolution melting PCR analysis for rapid genotyping of Burkholderia mallei. 61
29751195 2018
46
The Mla Pathway Plays an Essential Role in the Intrinsic Resistance of Burkholderia cepacia Complex Species to Antimicrobials and Host Innate Components. 61
29986943 2018
47
Larvicidal efficacy of Adiantobischrysene from Adiantum latifolium against Oryctes rhinoceros through disrupting metamorphosis and impeding microbial mediated digestion. 61
29393564 2018
48
Use of Immunohistochemistry to Demonstrate In Vivo Expression of the Burkholderia mallei Virulence Factor BpaB During Experimental Glanders. 61
29145795 2018
49
Mutations in MetG (methionyl-tRNA synthetase) and TrmD [tRNA (guanine-N1)-methyltransferase] conferring meropenem tolerance in Burkholderia thailandensis. 61
29136176 2018
50
Development of a real-time loop-mediated isothermal amplification assay for detection of Burkholderia mallei. 61
28649808 2018

Variations for Glanders

Expression for Glanders

Search GEO for disease gene expression data for Glanders.

Pathways for Glanders

Pathways related to Glanders according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.36 TLR5 TLR4 CD4
2
Show member pathways
11.09 TLR5 TLR4 CD4
3 10.56 TLR5 TLR4 HSPD1

GO Terms for Glanders

Cellular components related to Glanders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early endosome GO:0005769 9.26 TLR4 NUMB HSPD1 CD4
2 lipopolysaccharide receptor complex GO:0046696 8.62 TLR4 HSPD1

Biological processes related to Glanders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of macrophage activation GO:0043032 9.26 TLR4 HSPD1
2 positive regulation of interferon-alpha production GO:0032727 9.16 TLR4 HSPD1
3 T cell activation GO:0042110 9.13 HSPD1 CD8A CD4
4 MyD88-dependent toll-like receptor signaling pathway GO:0002755 8.8 TLR5 TLR4 HSPD1

Sources for Glanders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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