MCID: GLN002
MIFTS: 36

Glanders

Categories: Endocrine diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Glanders

MalaCards integrated aliases for Glanders:

Name: Glanders 12 53 3 44 15 17 72 33
Burkholderia Mallei 53 3
Infection Due to Pseudomonas Mallei 12
Burkholderia Mallei Infection 53
Farcy Pipes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13444
ICD9CM 35 024
MeSH 44 D005896
NCIt 50 C34638
SNOMED-CT 68 35322000 4639008
ICD10 33 A24.0
UMLS 72 C0017589

Summaries for Glanders

Disease Ontology : 12 A primary bacterial infectious disease that results in septicemic infection, has material basis in Burkholderia mallei, which is transmitted by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs.

MalaCards based summary : Glanders, also known as burkholderia mallei, is related to bacterial infectious disease and melioidosis. An important gene associated with Glanders is PSAP (Prosaposin), and among its related pathways/superpathways are Microglia Activation During Neuroinflammation: Overview and NF-kappa B signaling pathway. Affiliated tissues include lung, eye and testes, and related phenotypes are muscle and renal/urinary system

CDC : 3 Glanders is an infectious disease that is caused by the bacterium Burkholderia mallei. While people can get the disease, glanders is primarily a disease affecting horses. It also affects donkeys and mules and can be naturally contracted by other mammals such as goats, dogs, and cats.

Wikipedia : 75 Glanders is an infectious disease that occurs primarily in horses, mules, and donkeys. It can be... more...

Related Diseases for Glanders

Graphical network of the top 20 diseases related to Glanders:



Diseases related to Glanders

Symptoms & Phenotypes for Glanders

MGI Mouse Phenotypes related to Glanders:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.26 HSPD1 PLEKHG5 PSAP TLR4
2 renal/urinary system MP:0005367 8.92 GADD45B PLEKHG5 PSAP TLR4

Drugs & Therapeutics for Glanders

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Use of the Peristeen Bowel Irrigation System for People With Cauda Equina Syndrome Completed NCT01784328

Search NIH Clinical Center for Glanders

Cochrane evidence based reviews: glanders

Genetic Tests for Glanders

Anatomical Context for Glanders

MalaCards organs/tissues related to Glanders:

41
Lung, Eye, Testes, Liver, Skin, Bone, Spleen

Publications for Glanders

Articles related to Glanders:

(show top 50) (show all 573)
# Title Authors PMID Year
1
Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens. 38
31164713 2019
2
Development of Rose Bengal test against mallein test for rapid diagnosis of equine glanders. 38
31041722 2019
3
First record of Burkholderia mallei Turkey 10 strain originating from glanderous horses from Brazil. 38
31321739 2019
4
Spatiotemporal Analysis of Glanders in Brazil. 38
31203979 2019
5
Evaluation of Burkholderia mallei ΔtonB Δhcp1 (CLH001) as a live attenuated vaccine in murine models of glanders and melioidosis. 38
31306423 2019
6
A Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human- and Animal-Pathogenic Burkholderia Species. 38
31353766 2019
7
A real-time loop mediated isothermal amplification assay for molecular detection of Burkholderia mallei, the aetiological agent of a zoonotic and re-emerging disease glanders. 38
30958991 2019
8
A novel selective medium for the isolation of Burkholderia mallei from equine specimens. 38
31064357 2019
9
Burkholderia mallei: The dynamics of networks and disease transmission. 38
30427593 2019
10
An increase in intracellular p62/NBR1 and persistence of Burkholderia mallei and B. pseudomallei in infected mice linked to autophagy deficiency. 38
30569531 2019
11
Development of a rapid and sensitive recombinase polymerase amplification-lateral flow assay for detection of Burkholderia mallei. 38
30650261 2019
12
[Preparation for state registration of the reagent kit for the detection and differentiation of the DNA of burkholderia «pseudomallei» group.] 38
31012558 2019
13
Antibodies Are Major Drivers of Protection against Lethal Aerosol Infection with Highly Pathogenic Burkholderia spp. 38
30602525 2019
14
Rapid detection of Burkholderia pseudomallei with a lateral flow recombinase polymerase amplification assay. 38
31283772 2019
15
Burkholderia pseudomallei ΔtonB Δhcp1 Live Attenuated Vaccine Strain Elicits Full Protective Immunity against Aerosolized Melioidosis Infection. 38
30602524 2019
16
Evaluation of the comparative accuracy of the complement fixation test, Western blot and five enzyme-linked immunosorbent assays for serodiagnosis of glanders. 38
30951554 2019
17
Molecular Mechanisms of AhpC in Resistance to Oxidative Stress in Burkholderia thailandensis. 38
31338075 2019
18
Polysaccharides from Burkholderia species as targets for vaccine development, immunomodulation and chemical synthesis. 38
30023998 2018
19
Rapid antimicrobial susceptibility testing and β-lactam-induced cell morphology changes of Gram-negative biological threat pathogens by optical screening. 38
30563467 2018
20
Genome rearrangements and selection in multi-chromosome bacteria Burkholderia spp. 38
30587126 2018
21
[Georg von Hofmann-Wellenhof-130 years ago the first victim at the beginning of the investigation of infectious diseases in Austria]. 38
30539319 2018
22
The Mla Pathway Plays an Essential Role in the Intrinsic Resistance of Burkholderia cepacia Complex Species to Antimicrobials and Host Innate Components. 38
29986943 2018
23
High-resolution melting PCR analysis for rapid genotyping of Burkholderia mallei. 38
29751195 2018
24
Larvicidal efficacy of Adiantobischrysene from Adiantum latifolium against Oryctes rhinoceros through disrupting metamorphosis and impeding microbial mediated digestion. 38
29393564 2018
25
Use of Immunohistochemistry to Demonstrate In Vivo Expression of the Burkholderia mallei Virulence Factor BpaB During Experimental Glanders. 38
29145795 2018
26
Mutations in MetG (methionyl-tRNA synthetase) and TrmD [tRNA (guanine-N1)-methyltransferase] conferring meropenem tolerance in Burkholderia thailandensis. 38
29136176 2018
27
Development of a real-time loop-mediated isothermal amplification assay for detection of Burkholderia mallei. 38
28649808 2018
28
[The development and application of reagents kit for detection RNA of the causative agents of melioidosis and glanders by transcription-based amplification (NASBA) in real-time.] 38
30768889 2018
29
Proteomic Profiling of Burkholderia thailandensis During Host Infection Using Bio-Orthogonal Noncanonical Amino Acid Tagging (BONCAT). 38
30406044 2018
30
First molecular characterisation of a Brazilian Burkholderia mallei strain isolated from a mule in 2016. 38
29146548 2018
31
[Comparative analysis of LAMP and Real Time PCR methods to detect pathogens of glanders and meliodosis.] 38
30702233 2018
32
Improvement of recombinant-truncated Burkholderia motility protein A (BimA)-based indirect ELISA for equine glanders. 38
30303469 2018
33
Outer Membrane Vesicle Vaccines from Biosafe Surrogates Prevent Acute Lethal Glanders in Mice. 38
29320408 2018
34
Seroprevalence and risk factors of glanders in working equines - Findings of a cross-sectional study in Punjab province of Pakistan. 38
28760480 2017
35
Safety and Accuracy of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Highly Pathogenic Organisms. 38
29021156 2017
36
A Burkholderia pseudomallei Outer Membrane Vesicle Vaccine Provides Cross Protection against Inhalational Glanders in Mice and Non-Human Primates. 38
29232837 2017
37
The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy. 38
29286449 2017
38
Development of a multiplex PCR assay for the detection and differentiation of Burkholderia pseudomallei, Burkholderia mallei, Burkholderia thailandensis, and Burkholderia cepacia complex. 38
28634144 2017
39
Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials? 38
28336210 2017
40
Vaccines for the Prevention of Melioidosis and Glanders. 38
29242769 2017
41
Antibodies against In Vivo-Expressed Antigens Are Sufficient To Protect against Lethal Aerosol Infection with Burkholderia mallei and Burkholderia pseudomallei. 38
28507073 2017
42
Identification of a new diagnostic antigen for glanders using immunoproteome analysis. 38
28750864 2017
43
First Draft Genome for a Burkholderia mallei Isolate Originating from a Glanderous Mule from Brazil. 38
28705969 2017
44
Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens. 38
28740137 2017
45
Innate immune response to Burkholderia mallei. 38
28177960 2017
46
Burkholderia thailandensis: Genetic Manipulation. 38
28510362 2017
47
Equine infectious anemia prevalence in feral donkeys from Northeast Brazil. 38
28460747 2017
48
From glanders to globulins: A study in comparative medicine. 38
26307410 2017
49
Draft Genome Sequences of Two Clinical Isolates of Burkholderia mallei Obtained from Nasal Swabs of Glanderous Equines in India. 38
28385832 2017
50
Preparing for biological threats: Addressing the needs of pregnant women. 38
28398677 2017

Variations for Glanders

Expression for Glanders

Search GEO for disease gene expression data for Glanders.

Pathways for Glanders

Pathways related to Glanders according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.26 TLR4 HSPD1
2 10.96 TLR4 GADD45B
3 10.37 TLR4 HSPD1

GO Terms for Glanders

Cellular components related to Glanders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide receptor complex GO:0046696 8.62 TLR4 HSPD1

Biological processes related to Glanders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.58 PLEKHG5 HSPD1 GADD45B
2 positive regulation of JNK cascade GO:0046330 9.48 TLR4 GADD45B
3 positive regulation of interleukin-6 production GO:0032755 9.43 TLR4 HSPD1
4 positive regulation of interferon-gamma production GO:0032729 9.37 TLR4 HSPD1
5 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.32 TLR4 HSPD1
6 positive regulation of interleukin-12 production GO:0032735 9.26 TLR4 HSPD1
7 positive regulation of inflammatory response GO:0050729 9.16 TLR4
8 positive regulation of interleukin-10 production GO:0032733 9.16 TLR4 HSPD1
9 positive regulation of macrophage activation GO:0043032 8.96 TLR4 HSPD1
10 positive regulation of interferon-alpha production GO:0032727 8.62 TLR4 HSPD1

Molecular functions related to Glanders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 single-stranded DNA binding GO:0003697 8.65 HSPD1
2 lipopolysaccharide binding GO:0001530 8.62 TLR4 HSPD1

Sources for Glanders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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