MCID: GLN002
MIFTS: 41

Glanders

Categories: Rare diseases, Infectious diseases, Endocrine diseases

Aliases & Classifications for Glanders

MalaCards integrated aliases for Glanders:

Name: Glanders 12 53 3 44 15 73
Infection Due to Pseudomonas Mallei 12
Burkholderia Mallei Infection 53
Burkholderia Mallei 53
Farcy Pipes 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13444
ICD10 33 A24.0
ICD9CM 35 024
MeSH 44 D005896
NCIt 50 C34638
SNOMED-CT 68 35322000 4639008
UMLS 73 C0017589

Summaries for Glanders

Disease Ontology : 12 A primary bacterial infectious disease that results in septicemic infection, has material basis in Burkholderia mallei, which is transmitted by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs.

MalaCards based summary : Glanders, also known as infection due to pseudomonas mallei, is related to melioidosis and aging, and has symptoms including fever, chills and sweating. An important gene associated with Glanders is KRT3 (Keratin 3), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Melphalan and Menthol have been mentioned in the context of this disorder. Affiliated tissues include lung, eye and testes, and related phenotype is liver/biliary system.

CDC : 3 LocationLearn where glanders is found around the world.

Wikipedia : 76 Glanders (from Middle English glaundres or Old French glandres, both meaning glands;Latin: malleus,... more...

Related Diseases for Glanders

Diseases related to Glanders via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 melioidosis 11.0
2 aging 10.0
3 brucellosis 9.8
4 q fever 9.8
5 relapsing fever 9.8
6 tick-borne relapsing fever 9.8
7 actinomycosis 9.8
8 pemphigus 9.8
9 lymphangitis 9.8
10 pemphigus vegetans 9.8
11 campylobacteriosis 9.8 HCFC1 TLR4
12 bone fracture 9.6 LRP5 TLR4
13 niemann-pick disease 9.2 PSAP TLR4
14 trehalase deficiency 8.3 HCFC1 LRP5 PSAP

Graphical network of the top 20 diseases related to Glanders:



Diseases related to Glanders

Symptoms & Phenotypes for Glanders

Symptoms:

12
  • fever
  • chills
  • sweating
  • muscle aches
  • chest pain
  • muscle tightness
  • headache
  • mucopurulent nasal discharge
  • nodular lesions in the lungs

MGI Mouse Phenotypes related to Glanders:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.92 LRP5 PSAP TLR4 HCFC1

Drugs & Therapeutics for Glanders

Drugs for Glanders (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 1 148-82-3 4053 460612
2
Menthol Approved Phase 1 2216-51-5 16666
3 Anesthetics Phase 1,Not Applicable
4 Alkylating Agents Phase 1
5 Antineoplastic Agents, Alkylating Phase 1
6 Immunosuppressive Agents Phase 1
7 Liver Extracts Phase 1
8
Chloroprocaine Approved 133-16-4 8612
9
Procaine Approved, Investigational, Vet_approved 59-46-1 4914
10
Imidacloprid Vet_approved 105827-78-9 86418
11 Anesthetics, Local
12 Central Nervous System Depressants
13 Peripheral Nervous System Agents
14 Analgesics
15 Analgesics, Non-Narcotic
16 Anti-Inflammatory Agents
17 Anti-Inflammatory Agents, Non-Steroidal
18 Antirheumatic Agents

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Glaucoma Treatment by Cyclo-coagulation Using High Intensity Focused Ultrasound (HIFU) Completed NCT01592955 Phase 4
2 Spinal Magnetic Stimulation in Neuropathic Pain Completed NCT00443469 Phase 3
3 Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods) Unknown status NCT02591901 Phase 2 Uro vaxom
4 Hypofractionated Radiotherapy (16/2) for the Palliation of Complicated Bone Metastases in Patients With KPS Completed NCT02376322 Phase 2
5 Single Versus Multifraction Salvage Spine Stereotactic Radiosurgery for Previously Irradiated Spinal Metastases Recruiting NCT03028337 Phase 2
6 Trial for Salvage Re-Irradiation of Metastatic Spine Lesions Using Single-Fraction Stereotactic Radiosurgery Recruiting NCT02278744 Phase 1
7 Intra-arterial Chemotherapy for Spinal Metastases Recruiting NCT01637766 Phase 1 Melphalan (intra-arterial infusion)
8 High Dose Rate Brachyablation of Primary Liver Lesions Recruiting NCT02893982 Phase 1
9 Evaluation of Minimally Invasive Microdiscectomy Versus Conventional Open Microdiscectomy For Lumbar Herniated Disc Unknown status NCT00927056 Not Applicable
10 Peristeen Bowel Irrigation System in Cauda Equina Completed NCT01784328 Not Applicable
11 Observational Prospective Study on 2-chloroprocaine Hydrochloride 1% Safety in Intrathecal Anaesthesia Completed NCT02067806 Spinal administration of chloroprocaine
12 The Effect of Spinal Flexion in the Lateral Decubitus Position on the Unilaterality During Spinal Anesthesia Completed NCT01321684 Not Applicable
13 Characteristics of Back Pain Callers Completed NCT03474068
14 Neurologic Complications in Spinal Deformity Surgery Completed NCT01305343
15 Glaucoma Treatment by Circular Cyclocoagulation Using High Intensity Focused Ultrasound With the EYEOP Medical Device Completed NCT01338467 Not Applicable
16 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
17 BLB Study Back or Leg Pain and Bladder Symptoms Study Recruiting NCT03325374
18 Implementation of a "Remission" Consultation in the Management of Patients Treated for Localized Breast Cancer Recruiting NCT02740491
19 Stereotactic Body Radiotherapy Boost After Palliative Radiotherapy for Spinal Cord Compression Not yet recruiting NCT03529708 Not Applicable
20 Post-void Bladder Scanning in Acute Cauda Equina Syndrome Withdrawn NCT02806167 Not Applicable

Search NIH Clinical Center for Glanders

Cochrane evidence based reviews: glanders

Genetic Tests for Glanders

Anatomical Context for Glanders

MalaCards organs/tissues related to Glanders:

41
Lung, Eye, Testes, Liver, Bone, Breast, Spinal Cord

Publications for Glanders

Articles related to Glanders:

(show top 50) (show all 144)
# Title Authors Year
1
Outer Membrane Vesicle Vaccines from Biosafe Surrogates Prevent Acute Lethal Glanders in Mice. ( 29320408 )
2018
2
Use of Immunohistochemistry to Demonstrate In Vivo Expression of the Burkholderia mallei Virulence Factor BpaB During Experimental Glanders. ( 29145795 )
2018
3
Seroprevalence and risk factors of glanders in working equines - Findings of a cross-sectional study in Punjab province of Pakistan. ( 28760480 )
2017
4
Vaccines for the Prevention of Melioidosis and Glanders. ( 29242769 )
2017
5
Identification of a new diagnostic antigen for glanders using immunoproteome analysis. ( 28750864 )
2017
6
A Burkholderia pseudomallei Outer Membrane Vesicle Vaccine Provides Cross Protection against Inhalational Glanders in Mice and Non-Human Primates. ( 29232837 )
2017
7
Glanders And Melioidosis ( 28846298 )
2017
8
Burkholderia mallei CLH001 Attenuated Vaccine Strain Is Immunogenic and Protects against Acute Respiratory Glanders. ( 27271739 )
2016
9
Harmonising diagnostic testing for glanders in equids. ( 27313253 )
2016
10
Interlaboratory ring trial to evaluate CFT proficiency of European laboratories for diagnosis of glanders in equines. ( 27122499 )
2016
11
Glanders and history. ( 27339929 )
2016
12
Melioidosis and glanders modulation of the innate immune system: barriers to current and future vaccine approaches. ( 27010618 )
2016
13
Phenotypic Characterization of a Novel Virulence-Factor Deletion Strain of Burkholderia mallei That Provides Partial Protection against Inhalational Glanders in Mice. ( 26955620 )
2016
14
Glanders and the risk for its introduction through the international movement of horses. ( 27288893 )
2016
15
From glanders to globulins: A study in comparative medicine. ( 26307410 )
2015
16
Efficacy of Postexposure Therapy against Glanders in Mice. ( 25645854 )
2015
17
Surveillance focus: glanders. ( 26183359 )
2015
18
Pathological findings and diagnostic implications of a rhesus macaque (Macacca mulatta) model of aerosol-exposure to Burkholderia mallei (glanders). ( 25850696 )
2015
19
Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders. ( 26148026 )
2015
20
Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine. ( 25533326 )
2015
21
Optimization and validation of indirect ELISA using truncated TssB protein for the serodiagnosis of glanders amongst equines. ( 24672321 )
2014
22
Comparative experimental subcutaneous glanders and melioidosis in the common marmoset (Callithrix jacchus). ( 25477002 )
2014
23
Genotyping of Burkholderia mallei from an outbreak of glanders in Bahrain suggests multiple introduction events. ( 25255232 )
2014
24
Effect of incubation temperature on the diagnostic sensitivity of the glanders complement fixation test. ( 25812210 )
2014
25
Assessment of the effectiveness of the PPD-mallein produced in Brazil for diagnosing glanders in mules. ( 24159303 )
2013
26
From glanders to Hendra virus: 125 years of equine infectious diseases. ( 23997164 )
2013
27
Glanders: an overview of infection in humans. ( 24004906 )
2013
28
Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glanders. ( 23517714 )
2013
29
Glanders in animals: a review on epidemiology, clinical presentation, diagnosis and countermeasures. ( 22630609 )
2013
30
Humoral immune responses in a human case of glanders. ( 22398248 )
2012
31
Evaluation of recombinant proteins of Burkholderia mallei for serodiagnosis of glanders. ( 22695165 )
2012
32
Development and validation of a method for purification of mallein for the diagnosis of glanders in equines. ( 22937975 )
2012
33
Glanders outbreak at Tehran Zoo, Iran. ( 22783454 )
2012
34
Development of hydrolysis probe-based real-time PCR for identification of virulent gene targets of Burkholderia pseudomallei and B. mallei--a retrospective study on archival cases of service members with melioidosis and glanders. ( 22360070 )
2012
35
Emergence and re-emergence of glanders in India: a description of outbreaks from 2006 to 2011. ( 22718333 )
2012
36
Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders. ( 22912938 )
2012
37
Development of novel O-polysaccharide based glycoconjugates for immunization against glanders. ( 23205347 )
2012
38
Effectiveness of an antimicrobial treatment scheme in a confined glanders outbreak. ( 23134717 )
2012
39
Performance of complement fixation test and confirmatory immunoblot as two-cascade testing approach for serodiagnosis of glanders in an endemic region of South East Asia. ( 22515029 )
2012
40
Recent progress in melioidosis and glanders. ( 22529846 )
2012
41
Protective antigens against glanders identified by expression library immunization. ( 22125550 )
2011
42
Diagnostic assays for glanders. ( 22184353 )
2011
43
Outer membrane proteome of Burkholderia pseudomallei and Burkholderia mallei from diverse growth conditions. ( 21391724 )
2011
44
Comparative evaluation of three commercially available complement fixation test antigens for the diagnosis of glanders. ( 21896565 )
2011
45
Construction and molecular characterization of mouse single-chain variable fragment antibodies against Burkholderia mallei and Burkholderia pseudomallei. ( 21172353 )
2011
46
Use of a Western blot technique for the serodiagnosis of glanders. ( 21247488 )
2011
47
Use of a recombinant burkholderia intracellular motility a protein for immunodiagnosis of glanders. ( 21752949 )
2011
48
Re-emergence of glanders in India - Report of Maharashtra state. ( 23100851 )
2010
49
Present and future therapeutic strategies for melioidosis and glanders. ( 20192686 )
2010
50
Glanders in donkeys (Equus Asinus) in the state of pernambuco, Brazil: A case report. ( 24031474 )
2010

Variations for Glanders

Expression for Glanders

Search GEO for disease gene expression data for Glanders.

Pathways for Glanders

Pathways related to Glanders according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.17 LRP5 TLR4
2 10.49 LRP5 TLR4

GO Terms for Glanders

Cellular components related to Glanders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.62 LRP5 TLR4

Biological processes related to Glanders according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 8.8 HCFC1 LRP5 TLR4

Sources for Glanders

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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