MCID: GLS012
MIFTS: 31

Glassy Cell Carcinoma of the Cervix

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Glassy Cell Carcinoma of the Cervix

MalaCards integrated aliases for Glassy Cell Carcinoma of the Cervix:

Name: Glassy Cell Carcinoma of the Cervix 52
Glassy Cell Adenocarcinoma of the Uterine Cervix 52
Gcc of the Cervix 52

Classifications:



Summaries for Glassy Cell Carcinoma of the Cervix

MalaCards based summary : Glassy Cell Carcinoma of the Cervix, also known as glassy cell adenocarcinoma of the uterine cervix, is related to cervical adenocarcinoma and mucinous adenocarcinoma. An important gene associated with Glassy Cell Carcinoma of the Cervix is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gastric cancer and Development Ligand-independent activation of ESR1 and ESR2. Affiliated tissues include cervix and ovary, and related phenotypes are limbs/digits/tail and neoplasm

Wikipedia : 74 Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour... more...

Related Diseases for Glassy Cell Carcinoma of the Cervix

Diseases related to Glassy Cell Carcinoma of the Cervix via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 cervical adenocarcinoma 30.0 ESR1 ERBB2
2 mucinous adenocarcinoma 29.3 PGR ESR1 ERBB2
3 glassy cell carcinoma of the cervix uteri 12.7
4 cervical cancer 10.5
5 adenosquamous carcinoma 10.5
6 suppressor of tumorigenicity 3 10.3
7 large cell carcinoma 10.3
8 adenocarcinoma 10.2
9 appendix adenocarcinoma 10.2
10 keratinizing squamous cell carcinoma 10.2
11 rare tumor 10.2
12 bartholin's gland adenoid cystic carcinoma 10.0 PGR ESR1
13 chronic tympanitis 10.0 PGR ESR1
14 bartholin's gland adenoma 10.0 PGR ESR1
15 granulomatous endometritis 10.0 PGR ESR1
16 endometritis 10.0 PGR ESR1
17 bartholin's gland benign neoplasm 10.0 PGR ESR1
18 vestibular gland benign neoplasm 10.0 PGR ESR1
19 lung leiomyoma 10.0 PGR ESR1
20 leiomyoma 10.0 PGR ESR1
21 myoma 10.0 PGR ESR1
22 vulvar syringoma 10.0 PGR ESR1
23 trigonitis 10.0 PGR ESR1
24 vagina leiomyosarcoma 10.0 PGR ESR1
25 leiomyosarcoma 10.0 PGR ESR1
26 adult type testicular granulosa cell tumor 10.0 PGR ESR1
27 ovarian seromucinous carcinoma 10.0 PGR ESR1
28 breast leiomyoma 10.0 PGR ESR1
29 intravenous leiomyomatosis 10.0 PGR ESR1
30 leiomyomatosis 10.0 PGR ESR1
31 liver leiomyoma 10.0 PGR ESR1
32 mammographic density 10.0 PGR ESR1
33 vulvar leiomyoma 10.0 PGR ESR1
34 bizarre leiomyoma 10.0 PGR ESR1
35 vaginal endometrial stromal sarcoma 10.0 PGR ESR1
36 endometrial stromal sarcoma 10.0 PGR ESR1
37 progesterone resistance 10.0 PGR ESR1
38 vagina sarcoma 10.0 PGR ESR1
39 endosalpingiosis 10.0 PGR ESR1
40 cervical mucinous adenocarcinoma 10.0 PGR ESR1
41 adenomyoma 10.0 PGR ESR1
42 gender identity disorder 10.0 PGR ESR1
43 juvenile nasopharyngeal angiofibroma 9.9 PGR ESR1
44 vulvar benign neoplasm 9.9 PGR ESR1
45 adult mesoblastic nephroma 9.9 PGR ESR1
46 vaginal cancer 9.9 PGR ESR1
47 ovarian endometrial cancer 9.9 PGR ESR1
48 estrogen excess 9.9 PGR ESR1
49 vaginal discharge 9.9 PGR ESR1
50 endocervical carcinoma 9.9 PGR ESR1

Graphical network of the top 20 diseases related to Glassy Cell Carcinoma of the Cervix:



Diseases related to Glassy Cell Carcinoma of the Cervix

Symptoms & Phenotypes for Glassy Cell Carcinoma of the Cervix

MGI Mouse Phenotypes related to Glassy Cell Carcinoma of the Cervix:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.13 ERBB2 ESR1 PGR
2 neoplasm MP:0002006 8.8 ERBB2 ESR1 PGR

Drugs & Therapeutics for Glassy Cell Carcinoma of the Cervix

Search Clinical Trials , NIH Clinical Center for Glassy Cell Carcinoma of the Cervix

Genetic Tests for Glassy Cell Carcinoma of the Cervix

Anatomical Context for Glassy Cell Carcinoma of the Cervix

MalaCards organs/tissues related to Glassy Cell Carcinoma of the Cervix:

40
Cervix, Ovary

Publications for Glassy Cell Carcinoma of the Cervix

Articles related to Glassy Cell Carcinoma of the Cervix:

(show all 31)
# Title Authors PMID Year
1
[Glassy cell carcinoma of the uterine cervix: An aggressive type of cancer]. 61
31431320 2019
2
Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications. 61
26974246 2016
3
Glassy cell carcinoma of the cervix and metastasis in episiotomy scar: a case report. 61
25062402 2015
4
[Glassy cell carcinoma of the cervix: report of a case and literature review]. 61
26664556 2015
5
Glassy cell carcinoma of the cervix: a literature review. 61
24792540 2014
6
[Glassy cell carcinoma: a rare cervical neoplasm. Case report of two patients and review of the literature]. 61
24819246 2014
7
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis. 61
24503463 2014
8
Glassy cell carcinoma of the cervix--a case report with review of the literature. 61
22384631 2011
9
Conservatively treated glassy cell carcinoma of the cervix. 61
18755015 2008
10
Glassy cell carcinoma of the cervix: cytologic features and expression of estrogen receptor, progesterone receptor and Her2/neu protein. 61
16901007 2006
11
Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature. 61
15318016 2004
12
Glassy cell adenocarcinoma of the uterine cervix. 61
14749637 2004
13
Liquid-based cytology findings of glassy cell carcinoma of the cervix. Report of a case with histologic correlation and molecular analysis. 61
14969191 2004
14
Can glassy cell carcinoma of the cervix be diagnosed by Pap smear? 61
12462103 2002
15
Glassy cell carcinoma of the cervix revisited. 61
11972387 2002
16
Glassy cell carcinoma of the uterine cervix. Report of a case with cytohistologic and immunohistochemical study. 61
11393075 2001
17
Response of glassy-cell carcinoma of the cervix to cisplatin, epirubicin, and mitomycin C. 61
10791384 2000
18
Concomitant irradiation and dose-escalating carboplatin for locally advanced carcinoma of the uterine cervix: an updated report. 61
9499253 1998
19
Absence of estrogen and progesterone receptors in glassy cell carcinoma of the cervix. 61
9464737 1998
20
Glassy cell carcinoma of the cervix: a bimodal treatment strategy. 61
1541437 1992
21
Stage IB glassy cell carcinoma of the cervix diagnosed during pregnancy and recurring in a transposed ovary. 61
1916516 1991
22
[Glassy cell carcinoma of the cervix]. 61
1909675 1991
23
Glassy cell carcinoma of the endometrium. 61
1688542 1990
24
Glassy cell carcinoma of the cervix redefined. 61
3368169 1988
25
Glassy cell carcinoma of the cervix. Cytologic and clinicopathologic analysis. 61
6861073 1983
26
Glassy cell carcinoma of the cervix. 61
6296737 1982
27
Glassy cell carcinoma of the cervix: report of three cases. 61
7120471 1982
28
A clinicopathological study on glassy cell carcinoma of the cervix. 61
7234357 1981
29
Glassy-cell carcinoma of the cervix: case report with a light and electron microscopy study. 61
7233592 1980
30
Stage i B glassy cell carcinoma of the cervix with ovarian metastases. 61
858556 1977
31
Glassy cell carcinoma of the cervix. 61
1260713 1976

Variations for Glassy Cell Carcinoma of the Cervix

Cosmic variations for Glassy Cell Carcinoma of the Cervix:

9 (show top 50) (show all 305)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87935416 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 17:7675113-7675113 15
2 COSM87898709 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 15
3 COSM88037566 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 15
4 COSM87897839 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 15
5 COSM87898351 TP53 cervix,NS,carcinoma,adenocarcinoma c.743G>A p.R248Q 17:7674220-7674220 15
6 COSM90696350 STK11 cervix,NS,carcinoma,adenocarcinoma c.894C>A p.F298L 19:1221980-1221980 15
7 COSM90691877 STK11 cervix,NS,carcinoma,adenocarcinoma c.910C>T p.R304W 19:1221996-1221996 15
8 COSM96847086 PTEN cervix,NS,carcinoma,adenocarcinoma c.724G>T p.E242* 10:87957942-87957942 15
9 COSM96860667 PTEN cervix,NS,carcinoma,adenocarcinoma c.1093G>A p.V365I 10:87965353-87965353 15
10 COSM96843054 PTEN cervix,NS,carcinoma,adenocarcinoma c.697C>T p.R233* 10:87957915-87957915 15
11 COSM96842497 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>T p.R130* 10:87933147-87933147 15
12 COSM96842299 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>G p.R130G 10:87933147-87933147 15
13 COSM87132301 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3:179218294-179218294 15
14 COSM87132308 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>A p.E545K 3:179218303-179218303 15
15 COSM87132431 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3129G>A p.M1043I 3:179234286-179234286 15
16 COSM87132245 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3140A>G p.H1047R 3:179234297-179234297 15
17 COSM87138932 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1636C>G p.Q546E 3:179218306-179218306 15
18 COSM87133231 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.263G>A p.R88Q 3:179199088-179199088 15
19 COSM87135718 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>C p.E545Q 3:179218303-179218303 15
20 COSM87139841 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1638G>T p.Q546H 3:179218308-179218308 15
21 COSM87134376 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1616C>G p.P539R 3:179218286-179218286 15
22 COSM87133243 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1357G>A p.E453K 3:179210291-179210291 15
23 COSM97107359 NRAS cervix,NS,carcinoma,adenocarcinoma c.182A>G p.Q61R 1:114713908-114713908 15
24 COSM87804075 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>T p.G12C 12:25245351-25245351 15
25 COSM87804005 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 12:25245350-25245350 15
26 COSM87804028 KRAS cervix,NS,carcinoma,adenocarcinoma c.38G>A p.G13D 12:25245347-25245347 15
27 COSM87804068 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 12:25245351-25245351 15
28 COSM87804083 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>C p.G12A 12:25245350-25245350 15
29 COSM87805382 KRAS cervix,NS,carcinoma,adenocarcinoma c.175G>A p.A59T 12:25227349-25227349 15
30 COSM87805356 KRAS cervix,NS,carcinoma,adenocarcinoma c.183A>T p.Q61H 12:25227341-25227341 15
31 COSM87810371 KRAS cervix,NS,carcinoma,adenocarcinoma c.182A>C p.Q61P 12:25227342-25227342 15
32 COSM87804055 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>T p.G12V 12:25245350-25245350 15
33 COSM87804155 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>C p.G12R 12:25245351-25245351 15
34 COSM112989371 HRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 11:534289-534289 15
35 COSM84064156 GNA11 cervix,NS,carcinoma,adenocarcinoma c.972C>G p.I324M 19:3121071-3121071 15
36 COSM141955806 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1436G>C p.R479P 4:152326214-152326214 15
37 COSM141953409 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1513C>T p.R505C 4:152326137-152326137 15
38 COSM88595036 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.2260G>A p.V754M 17:39723963-39723963 15
39 COSM88585849 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.929C>T p.S310F 17:39711955-39711955 15
40 COSM88586417 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.2524G>A p.V842I 17:39725079-39725079 15
41 COSM88586423 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.929C>A p.S310Y 17:39711955-39711955 15
42 COSM150913532 CTNNB1 cervix,NS,carcinoma,adenocarcinoma c.110C>T p.S37F 3:41224622-41224622 15
43 COSM150914055 CTNNB1 cervix,NS,carcinoma,adenocarcinoma c.97T>G p.S33A 3:41224609-41224609 15
44 COSM150580638 BRAF cervix,NS,carcinoma,adenocarcinoma c.1787G>A p.G596D 7:140753348-140753348 15
45 COSM150564063 BRAF cervix,NS,carcinoma,adenocarcinoma c.1397G>T p.G466V 7:140781611-140781611 15
46 COSM150587390 BRAF cervix,NS,carcinoma,adenocarcinoma c.1789C>G p.L597V 7:140753346-140753346 15
47 COSM150567521 BRAF cervix,NS,carcinoma,adenocarcinoma c.1406G>A p.G469E 7:140781602-140781602 15
48 COSM88129409 ATM cervix,NS,carcinoma,adenocarcinoma c.7322T>G p.V2441G 11:108330228-108330228 15
49 COSM99448653 ALK cervix,NS,carcinoma,adenocarcinoma c.1396G>A p.D466N 2:29328368-29328368 15
50 COSM148932717 cervix,NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3:179218294-179218294 15

Expression for Glassy Cell Carcinoma of the Cervix

Search GEO for disease gene expression data for Glassy Cell Carcinoma of the Cervix.

Pathways for Glassy Cell Carcinoma of the Cervix

Pathways related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.8 PGR ESR1 ERBB2
2
Show member pathways
11.73 ESR1 ERBB2
3 11.68 ESR1 ERBB2
4
Show member pathways
11.57 PGR ESR1
5
Show member pathways
11.23 ESR1 ERBB2
6
Show member pathways
11.11 PGR ESR1
7
Show member pathways
10.83 PGR ESR1 ERBB2

GO Terms for Glassy Cell Carcinoma of the Cervix

Biological processes related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.16 ESR1 ERBB2
2 transcription initiation from RNA polymerase II promoter GO:0006367 8.96 PGR ESR1
3 steroid hormone mediated signaling pathway GO:0043401 8.62 PGR ESR1

Molecular functions related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 PGR ESR1 ERBB2
2 ATPase binding GO:0051117 9.26 PGR ESR1
3 steroid hormone receptor activity GO:0003707 9.16 PGR ESR1
4 nuclear receptor activity GO:0004879 8.96 PGR ESR1
5 steroid binding GO:0005496 8.62 PGR ESR1

Sources for Glassy Cell Carcinoma of the Cervix

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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