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MCID: GLS012
MIFTS: 30

Glassy Cell Carcinoma of the Cervix

Categories: Cancer diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Glassy Cell Carcinoma of the Cervix

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MalaCards integrated aliases for Glassy Cell Carcinoma of the Cervix:

Name: Glassy Cell Carcinoma of the Cervix 54
Glassy Cell Adenocarcinoma of the Uterine Cervix 54
Gcc of the Cervix 54

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
See all MalaCards categories (disease lists)


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Summaries for Glassy Cell Carcinoma of the Cervix

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MalaCards based summary : Glassy Cell Carcinoma of the Cervix, also known as glassy cell adenocarcinoma of the uterine cervix, is related to cervical adenocarcinoma and glassy cell carcinoma of the cervix uteri. An important gene associated with Glassy Cell Carcinoma of the Cervix is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gastric cancer and Development Ligand-independent activation of ESR1 and ESR2. Affiliated tissues include cervix, breast and ovary, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : 77 Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour... more...

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Related Diseases for Glassy Cell Carcinoma of the Cervix

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Diseases related to Glassy Cell Carcinoma of the Cervix via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 cervical adenocarcinoma 29.8 ERBB2 ESR1 PGR
2 glassy cell carcinoma of the cervix uteri 12.5
3 adenocarcinoma 10.3
4 adenoid cystic carcinoma 10.1 ERBB2 PGR
5 scirrhous adenocarcinoma 10.1 ERBB2 PGR
6 breast apocrine carcinoma 10.1 ERBB2 PGR
7 intracystic papillary adenoma 10.1 ERBB2 PGR
8 breast metaplastic carcinoma 10.1 ERBB2 PGR
9 progesterone-receptor negative breast cancer 10.1 ERBB2 PGR
10 uterine body mixed cancer 10.0 ERBB2 PGR
11 carcinosarcoma 10.0 ERBB2 PGR
12 microglandular adenosis 10.0 ERBB2 PGR
13 breast secretory carcinoma 10.0 ERBB2 PGR
14 mixed cell type cancer 10.0 ERBB2 PGR
15 bilateral breast cancer 10.0 ERBB2 PGR
16 primary peritoneal carcinoma 10.0 ERBB2 PGR
17 papillary adenocarcinoma 10.0 ERBB2 PGR
18 serous cystadenocarcinoma 10.0 ERBB2 PGR
19 comedo carcinoma 9.9 ERBB2 ESR1
20 cystadenocarcinoma 9.9 ERBB2 PGR
21 ovarian serous cystadenocarcinoma 9.9 ERBB2 PGR
22 papillary carcinoma 9.9 ERBB2 PGR
23 vestibular gland benign neoplasm 9.9 ESR1 PGR
24 lobular neoplasia 9.9 ERBB2 ESR1
25 bartholin's gland adenoma 9.9 ESR1 PGR
26 vulvar syringoma 9.9 ESR1 PGR
27 lung leiomyoma 9.9 ESR1 PGR
28 leiomyoma 9.9 ESR1 PGR
29 myoma 9.9 ESR1 PGR
30 vulvar benign neoplasm 9.9 ESR1 PGR
31 trigonitis 9.9 ESR1 PGR
32 vulvar leiomyoma 9.9 ESR1 PGR
33 uterine carcinosarcoma 9.9 ERBB2 PGR
34 hidradenocarcinoma 9.9 ERBB2 ESR1
35 predominantly cortical thymoma 9.9 ESR1 PGR
36 bartholin's gland benign neoplasm 9.9 ESR1 PGR
37 oncocytic breast carcinoma 9.9 ESR1 PGR
38 progesterone resistance 9.9 ESR1 PGR
39 endometrial squamous cell carcinoma 9.9 ESR1 PGR
40 cribriform carcinoma 9.9 ESR1 PGR
41 endometrial mucinous adenocarcinoma 9.9 ESR1 PGR
42 adenoid basal cell carcinoma 9.9 ESR1 PGR
43 peritoneal benign neoplasm 9.9 ESR1 PGR
44 gender identity disorder 9.9 ESR1 PGR
45 deep angioma 9.9 ESR1 PGR
46 diffuse peritoneal leiomyomatosis 9.9 ESR1 PGR
47 leiomyomatosis 9.9 ESR1 PGR
48 synchronous bilateral breast carcinoma 9.9 ESR1 PGR
49 female reproductive endometrioid cancer 9.9 ESR1 PGR
50 cervical carcinosarcoma 9.9 ESR1 PGR

Graphical network of the top 20 diseases related to Glassy Cell Carcinoma of the Cervix:



Diseases related to Glassy Cell Carcinoma of the Cervix
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Symptoms & Phenotypes for Glassy Cell Carcinoma of the Cervix

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MGI Mouse Phenotypes related to Glassy Cell Carcinoma of the Cervix:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.33 ERBB2 ESR1 PGR
2 muscle MP:0005369 9.13 ERBB2 ESR1 PGR
3 neoplasm MP:0002006 8.8 ERBB2 ESR1 PGR
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Drugs & Therapeutics for Glassy Cell Carcinoma of the Cervix

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Search Clinical Trials , NIH Clinical Center for Glassy Cell Carcinoma of the Cervix

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Genetic Tests for Glassy Cell Carcinoma of the Cervix

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Anatomical Context for Glassy Cell Carcinoma of the Cervix

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MalaCards organs/tissues related to Glassy Cell Carcinoma of the Cervix:

42
Cervix, Breast, Ovary, Lung, Bone, Prostate, Smooth Muscle
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Publications for Glassy Cell Carcinoma of the Cervix

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Articles related to Glassy Cell Carcinoma of the Cervix:

(show all 23)
# Title Authors Year
1
Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications. ( 26974246 )
2016
2
Glassy cell carcinoma of the cervix and metastasis in episiotomy scar: a case report. ( 25062402 )
2015
3
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis. ( 24503463 )
2014
4
Glassy cell carcinoma of the cervix: a literature review. ( 24792540 )
2014
5
Glassy cell carcinoma of the cervix--a case report with review of the literature. ( 22384631 )
2011
6
Conservatively treated glassy cell carcinoma of the cervix. ( 18755015 )
2008
7
Glassy cell carcinoma of the cervix: cytologic features and expression of estrogen receptor, progesterone receptor and Her2/neu protein. ( 16901007 )
2006
8
Liquid-based cytology findings of glassy cell carcinoma of the cervix. Report of a case with histologic correlation and molecular analysis. ( 14969191 )
2004
9
Glassy cell adenocarcinoma of the uterine cervix. ( 14749637 )
2004
10
Glassy cell carcinoma of the cervix revisited. ( 11972387 )
2002
11
Can glassy cell carcinoma of the cervix be diagnosed by Pap smear? ( 12462103 )
2002
12
Response of glassy-cell carcinoma of the cervix to cisplatin, epirubicin, and mitomycin C. ( 10791384 )
2000
13
Absence of estrogen and progesterone receptors in glassy cell carcinoma of the cervix. ( 9464737 )
1998
14
Glassy cell carcinoma of the cervix: a bimodal treatment strategy. ( 1541437 )
1992
15
Stage IB glassy cell carcinoma of the cervix diagnosed during pregnancy and recurring in a transposed ovary. ( 1916516 )
1991
16
Glassy cell carcinoma of the cervix redefined. ( 3368169 )
1988
17
Glassy cell carcinoma of the cervix. Cytologic and clinicopathologic analysis. ( 6861073 )
1983
18
Glassy cell carcinoma of the cervix. ( 6296737 )
1982
19
Glassy cell carcinoma of the cervix: report of three cases. ( 7120471 )
1982
20
A clinicopathological study on glassy cell carcinoma of the cervix. ( 7234357 )
1981
21
Glassy-cell carcinoma of the cervix: case report with a light and electron microscopy study. ( 7233592 )
1980
22
Stage i B glassy cell carcinoma of the cervix with ovarian metastases. ( 858556 )
1977
23
Glassy cell carcinoma of the cervix. ( 1260713 )
1976
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Variations for Glassy Cell Carcinoma of the Cervix

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Cosmic variations for Glassy Cell Carcinoma of the Cervix:

9 (show top 50) (show all 86)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM1235014 U2AF1 cervix,NS,carcinoma,adenocarcinoma c.467G>A p.R156H 21:43094670-43094670 0
2 COSM10648 TP53 cervix,NS,carcinoma,adenocarcinoma c.524G>A p.R175H 17:7675088-7675088 0
3 COSM44399 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 0
4 COSM10941 TP53 cervix,NS,carcinoma,adenocarcinoma c.730G>A p.G244S 17:7674233-7674233 0
5 COSM10725 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 0
6 COSM10662 TP53 cervix,NS,carcinoma,adenocarcinoma c.743G>A p.R248Q 17:7674220-7674220 0
7 COSM11333 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 17:7675113-7675113 0
8 COSM10656 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 0
9 COSM29468 STK11 cervix,NS,carcinoma,adenocarcinoma c.910C>T p.R304W 19:1221996-1221996 0
10 COSM29467 STK11 cervix,NS,carcinoma,adenocarcinoma c.894C>A p.F298L 19:1221980-1221980 0
11 COSM6967953 SF3B1 cervix,NS,carcinoma,adenocarcinoma c.1910C>G p.S637C 2:197402723-197402723 0
12 COSM6967952 SF3B1 cervix,NS,carcinoma,adenocarcinoma c.2323C>G p.R775G 2:197401789-197401789 0
13 COSM6923797 RET cervix,NS,carcinoma,adenocarcinoma c.1132G>A p.D378N 10:43109099-43109099 0
14 COSM5802682 PTPRD cervix,NS,carcinoma,adenocarcinoma c.3530G>A p.R1177H 9:8465650-8465650 0
15 COSM5154 PTEN cervix,NS,carcinoma,adenocarcinoma c.697C>T p.R233* 10:87957915-87957915 0
16 COSM5219 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>G p.R130G 10:87933147-87933147 0
17 COSM5056 PTEN cervix,NS,carcinoma,adenocarcinoma c.1093G>A p.V365I 10:87965353-87965353 0
18 COSM5152 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>T p.R130* 10:87933147-87933147 0
19 COSM88109 PTEN cervix,NS,carcinoma,adenocarcinoma c.724G>T p.E242* 10:87957942-87957942 0
20 COSM27133 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>C p.E545Q 3:179218303-179218303 0
21 COSM6147 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1636C>G p.Q546E 3:179218306-179218306 0
22 COSM763 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>A p.E545K 3:179218303-179218303 0
23 COSM29313 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3129G>A p.M1043I 3:179234286-179234286 0
24 COSM760 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3:179218294-179218294 0
25 COSM24712 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1638G>T p.Q546H 3:179218308-179218308 0
26 COSM775 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3140A>G p.H1047R 3:179234297-179234297 0
27 COSM759 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1616C>G p.P539R 3:179218286-179218286 0
28 COSM12584 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1357G>A p.E453K 3:179210291-179210291 0
29 COSM746 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.263G>A p.R88Q 3:179199088-179199088 0
30 COSM584 NRAS cervix,NS,carcinoma,adenocarcinoma c.182A>G p.Q61R 1:114713908-114713908 0
31 COSM521 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 12:25245350-25245350 0
32 COSM522 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>C p.G12A 12:25245350-25245350 0
33 COSM517 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 12:25245351-25245351 0
34 COSM532 KRAS cervix,NS,carcinoma,adenocarcinoma c.38G>A p.G13D 12:25245347-25245347 0
35 COSM516 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>T p.G12C 12:25245351-25245351 0
36 COSM520 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>T p.G12V 12:25245350-25245350 0
37 COSM551 KRAS cervix,NS,carcinoma,adenocarcinoma c.182A>C p.Q61P 12:25227342-25227342 0
38 COSM555 KRAS cervix,NS,carcinoma,adenocarcinoma c.183A>T p.Q61H 12:25227341-25227341 0
39 COSM518 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>C p.G12R 12:25245351-25245351 0
40 COSM546 KRAS cervix,NS,carcinoma,adenocarcinoma c.175G>A p.A59T 12:25227349-25227349 0
41 COSM96324 KEAP1 cervix,NS,carcinoma,adenocarcinoma c.778C>T p.R260* 19:10492124-10492124 0
42 COSM480 HRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 11:534289-534289 0
43 COSM5945795 GNA11 cervix,NS,carcinoma,adenocarcinoma c.972C>G p.I324M 19:3121071-3121071 0
44 COSM420169 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1436G>C p.R479P 4:152326214-152326214 0
45 COSM22932 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1393C>T p.R465C 4:152328233-152328233 0
46 COSM22975 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1513C>T p.R505C 4:152326137-152326137 0
47 COSM94225 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.929C>A p.S310Y 17:39711955-39711955 0
48 COSM5049502 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.2260G>A p.V754M 17:39723963-39723963 0
49 COSM48358 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.929C>T p.S310F 17:39711955-39711955 0
50 COSM6937049 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.2183C>T p.S728F 17:39723635-39723635 0
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Expression for Glassy Cell Carcinoma of the Cervix

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Search GEO for disease gene expression data for Glassy Cell Carcinoma of the Cervix.
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Pathways for Glassy Cell Carcinoma of the Cervix

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Pathways related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Gastric cancer 38
Show member pathways
 11.8 ERBB2 ESR1 PGR
2
Development Ligand-independent activation of ESR1 and ESR2 23
Show member pathways
 11.73 ERBB2 ESR1
3
Proteoglycans in cancer 38
11.67 ERBB2 ESR1
4
Cell cycle Role of SCF complex in cell cycle regulation 23
Show member pathways
 11.57 ESR1 PGR
5
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 67
Show member pathways
 11.23 ERBB2 ESR1
6
Nuclear Receptor transcription pathway 67
Show member pathways
 11.11 ESR1 PGR
7
Signaling by ERBB4 67
Show member pathways
 10.83 ERBB2 ESR1 PGR
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GO Terms for Glassy Cell Carcinoma of the Cervix

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Biological processes related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.16 ESR1 PGR
2 transcription, DNA-templated GO:0006351 8.96 ESR1
3 positive regulation of protein kinase B signaling GO:0051897 8.96 ERBB2 ESR1
4 steroid hormone mediated signaling pathway GO:0043401 8.62 ESR1 PGR

Molecular functions related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 ERBB2 ESR1 PGR
2 ATPase binding GO:0051117 9.26 ESR1 PGR
3 steroid hormone receptor activity GO:0003707 9.16 ESR1 PGR
4 nuclear receptor activity GO:0004879 8.96 ESR1 PGR
5 steroid binding GO:0005496 8.62 ESR1 PGR
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Sources for Glassy Cell Carcinoma of the Cervix

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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