Glassy Cell Carcinoma of the Cervix disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GLS012 MIFTS: 31	Glassy Cell Carcinoma of the Cervix Categories: Cancer diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Glassy Cell Carcinoma of the Cervix

MalaCards integrated aliases for Glassy Cell Carcinoma of the Cervix:

Name: Glassy Cell Carcinoma of the Cervix ⁵³

Glassy Cell Adenocarcinoma of the Uterine Cervix ⁵³

Gcc of the Cervix ⁵³

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases

See all MalaCards categories (disease lists)

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Summaries for Glassy Cell Carcinoma of the Cervix

MalaCards based summary : Glassy Cell Carcinoma of the Cervix, also known as glassy cell adenocarcinoma of the uterine cervix, is related to cervical adenocarcinoma and glassy cell carcinoma of the cervix uteri. An important gene associated with Glassy Cell Carcinoma of the Cervix is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gastric cancer and Development Ligand-independent activation of ESR1 and ESR2. Affiliated tissues include cervix, ovary and lung, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : ⁷⁶ Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour... more...

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Related Diseases for Glassy Cell Carcinoma of the Cervix

Diseases related to Glassy Cell Carcinoma of the Cervix via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)

#	Related Disease	Score	Top Affiliating Genes
1	cervical adenocarcinoma	30.0	ERBB2 ESR1 PGR
2	glassy cell carcinoma of the cervix uteri	12.5
3	adenocarcinoma	10.2
4	adenoid cystic carcinoma	10.1	ERBB2 PGR
5	scirrhous adenocarcinoma	10.1	ERBB2 PGR
6	breast apocrine carcinoma	10.0	ERBB2 PGR
7	intracystic papillary adenoma	10.0	ERBB2 PGR
8	breast metaplastic carcinoma	10.0	ERBB2 PGR
9	progesterone-receptor negative breast cancer	10.0	ERBB2 PGR
10	uterine body mixed cancer	10.0	ERBB2 PGR
11	carcinosarcoma	10.0	ERBB2 PGR
12	microglandular adenosis	10.0	ERBB2 PGR
13	breast secretory carcinoma	10.0	ERBB2 PGR
14	mixed cell type cancer	10.0	ERBB2 PGR
15	bilateral breast cancer	10.0	ERBB2 PGR
16	primary peritoneal carcinoma	10.0	ERBB2 PGR
17	papillary adenocarcinoma	10.0	ERBB2 PGR
18	serous cystadenocarcinoma	10.0	ERBB2 PGR
19	comedo carcinoma	10.0	ERBB2 ESR1
20	cystadenocarcinoma	10.0	ERBB2 PGR
21	ovarian serous cystadenocarcinoma	10.0	ERBB2 PGR
22	papillary carcinoma	9.9	ERBB2 PGR
23	vestibular gland benign neoplasm	9.9	ESR1 PGR
24	lobular neoplasia	9.9	ERBB2 ESR1
25	bartholin's gland adenoma	9.9	ESR1 PGR
26	vulvar syringoma	9.9	ESR1 PGR
27	lung leiomyoma	9.9	ESR1 PGR
28	leiomyoma	9.9	ESR1 PGR
29	myoma	9.9	ESR1 PGR
30	vulvar benign neoplasm	9.9	ESR1 PGR
31	trigonitis	9.9	ESR1 PGR
32	vulvar leiomyoma	9.9	ESR1 PGR
33	predominantly cortical thymoma	9.9	ESR1 PGR
34	uterine carcinosarcoma	9.9	ERBB2 PGR
35	hidradenocarcinoma	9.9	ERBB2 ESR1
36	bartholin's gland benign neoplasm	9.9	ESR1 PGR
37	oncocytic breast carcinoma	9.9	ESR1 PGR
38	progesterone resistance	9.9	ESR1 PGR
39	endometrial squamous cell carcinoma	9.9	ESR1 PGR
40	cribriform carcinoma	9.9	ESR1 PGR
41	endometrial mucinous adenocarcinoma	9.9	ESR1 PGR
42	adenoid basal cell carcinoma	9.9	ESR1 PGR
43	peritoneal benign neoplasm	9.9	ESR1 PGR
44	gender identity disorder	9.9	ESR1 PGR
45	deep angioma	9.9	ESR1 PGR
46	diffuse peritoneal leiomyomatosis	9.9	ESR1 PGR
47	leiomyomatosis	9.9	ESR1 PGR
48	synchronous bilateral breast carcinoma	9.9	ESR1 PGR
49	female reproductive endometrioid cancer	9.9	ESR1 PGR
50	cervical carcinosarcoma	9.9	ESR1 PGR

Graphical network of the top 20 diseases related to Glassy Cell Carcinoma of the Cervix:

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Symptoms & Phenotypes for Glassy Cell Carcinoma of the Cervix

MGI Mouse Phenotypes related to Glassy Cell Carcinoma of the Cervix:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail	MP:0005371	9.33	ERBB2 ESR1 PGR
2	muscle	MP:0005369	9.13	ERBB2 ESR1 PGR
3	neoplasm	MP:0002006	8.8	ERBB2 ESR1 PGR

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Drugs & Therapeutics for Glassy Cell Carcinoma of the Cervix

Search Clinical Trials , NIH Clinical Center for Glassy Cell Carcinoma of the Cervix

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Genetic Tests for Glassy Cell Carcinoma of the Cervix

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Anatomical Context for Glassy Cell Carcinoma of the Cervix

MalaCards organs/tissues related to Glassy Cell Carcinoma of the Cervix:

⁴¹

Cervix, Ovary, Lung, Bone, Prostate, Smooth Muscle

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Publications for Glassy Cell Carcinoma of the Cervix

Articles related to Glassy Cell Carcinoma of the Cervix:

(show all 23)

#	Title	Authors	Year
1	Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications. ( 26974246 )	McEachron T.A....Torno L.R.	2016
2	Glassy cell carcinoma of the cervix: a systematic review and meta-analysis. ( 24503463 )	Guitarte C....LEE Y.C.	2014
3	Glassy cell carcinoma of the cervix: a literature review. ( 24792540 )	Zolciak-Siwinska A....Jonska-Gmyrek J.	2014
4	Glassy Cell Carcinoma of the Cervix and Metastasis in Episiotomy Scar: A Case Report. ( 25062402 )	Carocha A.I....Jorge A.F.	2014
5	Glassy cell carcinoma of the cervix--a case report with review of the literature. ( 22384631 )	KosiA8iska-KaczyA8ska K....WielgoA9 M.	2011
6	Conservatively treated glassy cell carcinoma of the cervix. ( 18755015 )		2008
7	Glassy cell carcinoma of the cervix: cytologic features and expression of estrogen receptor, progesterone receptor and Her2/neu protein. ( 16901007 )		2006
8	Liquid-based cytology findings of glassy cell carcinoma of the cervix. Report of a case with histologic correlation and molecular analysis. ( 14969191 )	Ng W.K....Li A.S.	2004
9	Glassy cell adenocarcinoma of the uterine cervix. ( 14749637 )	Hopkins MP...Morley GW	2004
10	Glassy cell carcinoma of the cervix revisited. ( 11972387 )	Gray H.J....Paley P.J.	2002
11	Can glassy cell carcinoma of the cervix be diagnosed by Pap smear? ( 12462103 )		2002
12	Response of glassy-cell carcinoma of the cervix to cisplatin, epirubicin, and mitomycin C. ( 10791384 )		2000
13	Absence of estrogen and progesterone receptors in glassy cell carcinoma of the cervix. ( 9464737 )	Atlas I....Steinhoff M.M.	1998
14	Glassy cell carcinoma of the cervix: a bimodal treatment strategy. ( 1541437 )	Lotocki RJ...Fung FK	1992
15	Stage IB glassy cell carcinoma of the cervix diagnosed during pregnancy and recurring in a transposed ovary. ( 1916516 )	Reisinger SA...Jahshan A	1991
16	Glassy cell carcinoma of the cervix redefined. ( 3368169 )		1988
17	Glassy cell carcinoma of the cervix. Cytologic and clinicopathologic analysis. ( 6861073 )	Pak H.Y....Agliozzo C.M.	1983
18	Glassy cell carcinoma of the cervix. ( 6296737 )	Maier R.C....Norris H.J.	1982
19	Glassy cell carcinoma of the cervix: report of three cases. ( 7120471 )		1982
20	A clinicopathological study on glassy cell carcinoma of the cervix. ( 7234357 )	Tsukahara Y....Fukuta T.	1981
21	Glassy-cell carcinoma of the cervix: case report with a light and electron microscopy study. ( 7233592 )	Paulsen S.M....Nielsen V.T.	1980
22	Stage i B glassy cell carcinoma of the cervix with ovarian metastases. ( 858556 )	Nahhas W.A....Mortel R.	1977
23	Glassy cell carcinoma of the cervix. ( 1260713 )		1976

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Genes for Glassy Cell Carcinoma of the Cervix

Genes related to Glassy Cell Carcinoma of the Cervix (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PGR	Progesterone Receptor	Protein Coding	17.58	GeneCards inferred via : Publications (show sections)
2	ESR1	Estrogen Receptor 1	Protein Coding	17.23	GeneCards inferred via : Publications (show sections)
3	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	17.23	GeneCards inferred via : Publications (show sections)

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Variations for Glassy Cell Carcinoma of the Cervix

Cosmic variations for Glassy Cell Carcinoma of the Cervix:

⁹ (show top 50) (show all 83)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM1235014	U2AF1	cervix,NS,carcinoma,adenocarcinoma	c.467G>A	p.R156H	21:43094670-43094670	15
2	COSM10648	TP53	cervix,NS,carcinoma,adenocarcinoma	c.524G>A	p.R175H	17:7675088-7675088	15
3	COSM44399	TP53	cervix,NS,carcinoma,adenocarcinoma	c.677G>T	p.G226V	17:7674286-7674286	15
4	COSM10941	TP53	cervix,NS,carcinoma,adenocarcinoma	c.730G>A	p.G244S	17:7674233-7674233	15
5	COSM10725	TP53	cervix,NS,carcinoma,adenocarcinoma	c.701A>G	p.Y234C	17:7674262-7674262	15
6	COSM10662	TP53	cervix,NS,carcinoma,adenocarcinoma	c.743G>A	p.R248Q	17:7674220-7674220	15
7	COSM11333	TP53	cervix,NS,carcinoma,adenocarcinoma	c.499C>T	p.Q167*	17:7675113-7675113	15
8	COSM10656	TP53	cervix,NS,carcinoma,adenocarcinoma	c.742C>T	p.R248W	17:7674221-7674221	15
9	COSM29468	STK11	cervix,NS,carcinoma,adenocarcinoma	c.910C>T	p.R304W	19:1221996-1221996	15
10	COSM29467	STK11	cervix,NS,carcinoma,adenocarcinoma	c.894C>A	p.F298L	19:1221980-1221980	15
11	COSM6967953	SF3B1	cervix,NS,carcinoma,adenocarcinoma	c.1910C>G	p.S637C	2:197402723-197402723	15
12	COSM6967952	SF3B1	cervix,NS,carcinoma,adenocarcinoma	c.2323C>G	p.R775G	2:197401789-197401789	15
13	COSM6923797	RET	cervix,NS,carcinoma,adenocarcinoma	c.1132G>A	p.D378N	10:43109099-43109099	15
14	COSM5802682	PTPRD	cervix,NS,carcinoma,adenocarcinoma	c.3530G>A	p.R1177H	9:8465650-8465650	15
15	COSM5154	PTEN	cervix,NS,carcinoma,adenocarcinoma	c.697C>T	p.R233*	10:87957915-87957915	15
16	COSM5219	PTEN	cervix,NS,carcinoma,adenocarcinoma	c.388C>G	p.R130G	10:87933147-87933147	15
17	COSM5056	PTEN	cervix,NS,carcinoma,adenocarcinoma	c.1093G>A	p.V365I	10:87965353-87965353	15
18	COSM5152	PTEN	cervix,NS,carcinoma,adenocarcinoma	c.388C>T	p.R130*	10:87933147-87933147	15
19	COSM88109	PTEN	cervix,NS,carcinoma,adenocarcinoma	c.724G>T	p.E242*	10:87957942-87957942	15
20	COSM27133	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1633G>C	p.E545Q	3:179218303-179218303	15
21	COSM6147	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1636C>G	p.Q546E	3:179218306-179218306	15
22	COSM763	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1633G>A	p.E545K	3:179218303-179218303	15
23	COSM29313	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.3129G>A	p.M1043I	3:179234286-179234286	15
24	COSM760	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1624G>A	p.E542K	3:179218294-179218294	15
25	COSM24712	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1638G>T	p.Q546H	3:179218308-179218308	15
26	COSM775	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.3140A>G	p.H1047R	3:179234297-179234297	15
27	COSM759	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1616C>G	p.P539R	3:179218286-179218286	15
28	COSM12584	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1357G>A	p.E453K	3:179210291-179210291	15
29	COSM746	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.263G>A	p.R88Q	3:179199088-179199088	15
30	COSM584	NRAS	cervix,NS,carcinoma,adenocarcinoma	c.182A>G	p.Q61R	1:114713908-114713908	15
31	COSM517	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.34G>A	p.G12S	12:25245351-25245351	15
32	COSM521	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.35G>A	p.G12D	12:25245350-25245350	15
33	COSM532	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.38G>A	p.G13D	12:25245347-25245347	15
34	COSM522	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.35G>C	p.G12A	12:25245350-25245350	15
35	COSM516	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.34G>T	p.G12C	12:25245351-25245351	15
36	COSM520	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.35G>T	p.G12V	12:25245350-25245350	15
37	COSM551	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.182A>C	p.Q61P	12:25227342-25227342	15
38	COSM555	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.183A>T	p.Q61H	12:25227341-25227341	15
39	COSM518	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.34G>C	p.G12R	12:25245351-25245351	15
40	COSM96324	KEAP1	cervix,NS,carcinoma,adenocarcinoma	c.778C>T	p.R260*	19:10492124-10492124	15
41	COSM480	HRAS	cervix,NS,carcinoma,adenocarcinoma	c.34G>A	p.G12S	11:534289-534289	15
42	COSM5945795	GNA11	cervix,NS,carcinoma,adenocarcinoma	c.972C>G	p.I324M	19:3121071-3121071	15
43	COSM420169	FBXW7	cervix,NS,carcinoma,adenocarcinoma	c.1436G>C	p.R479P	4:152326214-152326214	15
44	COSM22932	FBXW7	cervix,NS,carcinoma,adenocarcinoma	c.1393C>T	p.R465C	4:152328233-152328233	15
45	COSM22975	FBXW7	cervix,NS,carcinoma,adenocarcinoma	c.1513C>T	p.R505C	4:152326137-152326137	15
46	COSM6937049	ERBB2	cervix,NS,carcinoma,adenocarcinoma	c.2183C>T	p.S728F	17:39723635-39723635	15
47	COSM48358	ERBB2	cervix,NS,carcinoma,adenocarcinoma	c.929C>T	p.S310F	17:39711955-39711955	15
48	COSM94225	ERBB2	cervix,NS,carcinoma,adenocarcinoma	c.929C>A	p.S310Y	17:39711955-39711955	15
49	COSM5683	CTNNB1	cervix,NS,carcinoma,adenocarcinoma	c.97T>G	p.S33A	3:41224609-41224609	15
50	COSM5662	CTNNB1	cervix,NS,carcinoma,adenocarcinoma	c.110C>T	p.S37F	3:41224622-41224622	15

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Expression for Glassy Cell Carcinoma of the Cervix

Search GEO for disease gene expression data for Glassy Cell Carcinoma of the Cervix.

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Pathways for Glassy Cell Carcinoma of the Cervix

Pathways related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	11.8	ERBB2 ESR1 PGR
2	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	11.73	ERBB2 ESR1
3	Proteoglycans in cancer ³⁷	11.67	ERBB2 ESR1
4	Cell cycle Role of SCF complex in cell cycle regulation ²² Show member pathways Cell cycle ESR1 regulation of G1/S transition ²² Cell cycle Regulation of G1/S transition (part 1) ²² Immune response MIF-JAB1 signaling ²²	11.57	ESR1 PGR
5	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁶ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁶ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁶ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁶ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁶	11.23	ERBB2 ESR1
6	Nuclear Receptor transcription pathway ⁶⁶ Show member pathways Nuclear Receptors ¹	11.11	ESR1 PGR
7	Signaling by ERBB4 ⁶⁶ Show member pathways Downregulation of ERBB4 signaling ⁶⁶ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁶	10.83	ERBB2 ESR1 PGR

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GO Terms for Glassy Cell Carcinoma of the Cervix

Biological processes related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transcription, DNA-templated	GO:0006351	9.32	ESR1 PGR
2	transcription initiation from RNA polymerase II promoter	GO:0006367	9.26	ESR1 PGR
3	positive regulation of protein kinase B signaling	GO:0051897	9.16	ERBB2 ESR1
4	phosphatidylinositol phosphorylation	GO:0046854	8.96	ERBB2 ESR1
5	steroid hormone mediated signaling pathway	GO:0043401	8.62	ESR1 PGR

Molecular functions related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.54	ERBB2 ESR1 PGR
2	ATPase binding	GO:0051117	9.32	ESR1 PGR
3	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	9.26	ERBB2 ESR1
4	steroid hormone receptor activity	GO:0003707	9.16	ESR1 PGR
5	nuclear receptor activity	GO:0004879	8.96	ESR1 PGR
6	steroid binding	GO:0005496	8.62	ESR1 PGR

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Sources for Glassy Cell Carcinoma of the Cervix

¹ BioSystems

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⁴¹ MalaCards

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⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

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⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia