MCID: GLS012
MIFTS: 31

Glassy Cell Carcinoma of the Cervix

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Glassy Cell Carcinoma of the Cervix

MalaCards integrated aliases for Glassy Cell Carcinoma of the Cervix:

Name: Glassy Cell Carcinoma of the Cervix 53
Glassy Cell Adenocarcinoma of the Uterine Cervix 53
Gcc of the Cervix 53

Classifications:



Summaries for Glassy Cell Carcinoma of the Cervix

MalaCards based summary : Glassy Cell Carcinoma of the Cervix, also known as glassy cell adenocarcinoma of the uterine cervix, is related to cervical adenocarcinoma and glassy cell carcinoma of the cervix uteri. An important gene associated with Glassy Cell Carcinoma of the Cervix is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gastric cancer and Development Ligand-independent activation of ESR1 and ESR2. Affiliated tissues include cervix and ovary, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : 75 Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour... more...

Related Diseases for Glassy Cell Carcinoma of the Cervix

Diseases related to Glassy Cell Carcinoma of the Cervix via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 cervical adenocarcinoma 29.5 PGR ESR1 ERBB2
2 glassy cell carcinoma of the cervix uteri 12.7
3 cervical cancer 10.5
4 adenosquamous carcinoma 10.5
5 suppressor of tumorigenicity 3 10.3
6 large cell carcinoma 10.3
7 adenocarcinoma 10.2
8 mucinous adenocarcinoma 10.2
9 appendix adenocarcinoma 10.2
10 keratinizing squamous cell carcinoma 10.2
11 rare tumor 10.2
12 bartholin's gland adenoma 10.1 PGR ESR1
13 vestibular gland benign neoplasm 10.1 PGR ESR1
14 lung leiomyoma 10.1 PGR ESR1
15 leiomyoma 10.1 PGR ESR1
16 myoma 10.1 PGR ESR1
17 vulvar syringoma 10.1 PGR ESR1
18 vulvar leiomyoma 10.1 PGR ESR1
19 trigonitis 10.1 PGR ESR1
20 vulvar benign neoplasm 10.1 PGR ESR1
21 predominantly cortical thymoma 10.1 PGR ESR1
22 oncocytic breast carcinoma 10.1 PGR ESR1
23 bartholin's gland benign neoplasm 10.1 PGR ESR1
24 cribriform carcinoma 10.1 PGR ESR1
25 endometrial squamous cell carcinoma 10.1 PGR ESR1
26 progesterone resistance 10.1 PGR ESR1
27 adenoid basal cell carcinoma 10.1 PGR ESR1
28 endometrial mucinous adenocarcinoma 10.1 PGR ESR1
29 synchronous bilateral breast carcinoma 10.1 PGR ESR1
30 diffuse peritoneal leiomyomatosis 10.1 PGR ESR1
31 leiomyomatosis 10.1 PGR ESR1
32 deep angioma 10.1 PGR ESR1
33 gender identity disorder 10.1 PGR ESR1
34 peritoneal benign neoplasm 10.1 PGR ESR1
35 cervical carcinosarcoma 10.1 PGR ESR1
36 female reproductive endometrioid cancer 10.1 PGR ESR1
37 glycogen-rich clear cell breast carcinoma 10.1 PGR ESR1
38 intramuscular hemangioma 10.1 PGR ESR1
39 estrogen excess 10.1 PGR ESR1
40 cervical clear cell adenocarcinoma 10.1 PGR ESR1
41 mammographic density 10.1 PGR ESR1
42 retinitis pigmentosa 47 10.0 PGR ESR1
43 adenosarcoma 10.0 PGR ESR1
44 retinitis pigmentosa 20 10.0 PGR ESR1
45 endometriosis of ovary 10.0 PGR ESR1
46 endometriosis 10.0 PGR ESR1
47 smooth muscle tumor 10.0 PGR ESR1
48 uterine benign neoplasm 10.0 PGR ESR1
49 prostatic hypertrophy 10.0 PGR ESR1
50 endometritis 10.0 PGR ESR1

Graphical network of the top 20 diseases related to Glassy Cell Carcinoma of the Cervix:



Diseases related to Glassy Cell Carcinoma of the Cervix

Symptoms & Phenotypes for Glassy Cell Carcinoma of the Cervix

MGI Mouse Phenotypes related to Glassy Cell Carcinoma of the Cervix:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.33 ERBB2 ESR1 PGR
2 muscle MP:0005369 9.13 ERBB2 ESR1 PGR
3 neoplasm MP:0002006 8.8 ERBB2 ESR1 PGR

Drugs & Therapeutics for Glassy Cell Carcinoma of the Cervix

Search Clinical Trials , NIH Clinical Center for Glassy Cell Carcinoma of the Cervix

Genetic Tests for Glassy Cell Carcinoma of the Cervix

Anatomical Context for Glassy Cell Carcinoma of the Cervix

MalaCards organs/tissues related to Glassy Cell Carcinoma of the Cervix:

41
Cervix, Ovary

Publications for Glassy Cell Carcinoma of the Cervix

Articles related to Glassy Cell Carcinoma of the Cervix:

(show all 31)
# Title Authors PMID Year
1
[Glassy cell carcinoma of the uterine cervix: An aggressive type of cancer]. 38
31431320 2019
2
Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications. 38
26974246 2016
3
Glassy cell carcinoma of the cervix and metastasis in episiotomy scar: a case report. 38
25062402 2015
4
[Glassy cell carcinoma of the cervix: report of a case and literature review]. 38
26664556 2015
5
Glassy cell carcinoma of the cervix: a literature review. 38
24792540 2014
6
[Glassy cell carcinoma: a rare cervical neoplasm. Case report of two patients and review of the literature]. 38
24819246 2014
7
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis. 38
24503463 2014
8
Glassy cell carcinoma of the cervix--a case report with review of the literature. 38
22384631 2011
9
Conservatively treated glassy cell carcinoma of the cervix. 38
18755015 2008
10
Glassy cell carcinoma of the cervix: cytologic features and expression of estrogen receptor, progesterone receptor and Her2/neu protein. 38
16901007 2006
11
Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature. 38
15318016 2004
12
Glassy cell adenocarcinoma of the uterine cervix. 38
14749637 2004
13
Liquid-based cytology findings of glassy cell carcinoma of the cervix. Report of a case with histologic correlation and molecular analysis. 38
14969191 2004
14
Can glassy cell carcinoma of the cervix be diagnosed by Pap smear? 38
12462103 2002
15
Glassy cell carcinoma of the cervix revisited. 38
11972387 2002
16
Glassy cell carcinoma of the uterine cervix. Report of a case with cytohistologic and immunohistochemical study. 38
11393075 2001
17
Response of glassy-cell carcinoma of the cervix to cisplatin, epirubicin, and mitomycin C. 38
10791384 2000
18
Concomitant irradiation and dose-escalating carboplatin for locally advanced carcinoma of the uterine cervix: an updated report. 38
9499253 1998
19
Absence of estrogen and progesterone receptors in glassy cell carcinoma of the cervix. 38
9464737 1998
20
Glassy cell carcinoma of the cervix: a bimodal treatment strategy. 38
1541437 1992
21
Stage IB glassy cell carcinoma of the cervix diagnosed during pregnancy and recurring in a transposed ovary. 38
1916516 1991
22
[Glassy cell carcinoma of the cervix]. 38
1909675 1991
23
Glassy cell carcinoma of the endometrium. 38
1688542 1990
24
Glassy cell carcinoma of the cervix redefined. 38
3368169 1988
25
Glassy cell carcinoma of the cervix. Cytologic and clinicopathologic analysis. 38
6861073 1983
26
Glassy cell carcinoma of the cervix. 38
6296737 1982
27
Glassy cell carcinoma of the cervix: report of three cases. 38
7120471 1982
28
A clinicopathological study on glassy cell carcinoma of the cervix. 38
7234357 1981
29
Glassy-cell carcinoma of the cervix: case report with a light and electron microscopy study. 38
7233592 1980
30
Stage i B glassy cell carcinoma of the cervix with ovarian metastases. 38
858556 1977
31
Glassy cell carcinoma of the cervix. 38
1260713 1976

Variations for Glassy Cell Carcinoma of the Cervix

Cosmic variations for Glassy Cell Carcinoma of the Cervix:

9 (show top 50) (show all 86)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM1235014 U2AF1 cervix,NS,carcinoma,adenocarcinoma c.467G>A p.R156H 21:43094670-43094670 24
2 COSM10648 TP53 cervix,NS,carcinoma,adenocarcinoma c.524G>A p.R175H 17:7675088-7675088 24
3 COSM44399 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 24
4 COSM10941 TP53 cervix,NS,carcinoma,adenocarcinoma c.730G>A p.G244S 17:7674233-7674233 24
5 COSM10725 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 24
6 COSM10662 TP53 cervix,NS,carcinoma,adenocarcinoma c.743G>A p.R248Q 17:7674220-7674220 24
7 COSM11333 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 17:7675113-7675113 24
8 COSM10656 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 24
9 COSM29468 STK11 cervix,NS,carcinoma,adenocarcinoma c.910C>T p.R304W 19:1221996-1221996 24
10 COSM29467 STK11 cervix,NS,carcinoma,adenocarcinoma c.894C>A p.F298L 19:1221980-1221980 24
11 COSM6967953 SF3B1 cervix,NS,carcinoma,adenocarcinoma c.1910C>G p.S637C 2:197402723-197402723 24
12 COSM6967952 SF3B1 cervix,NS,carcinoma,adenocarcinoma c.2323C>G p.R775G 2:197401789-197401789 24
13 COSM6923797 RET cervix,NS,carcinoma,adenocarcinoma c.1132G>A p.D378N 10:43109099-43109099 24
14 COSM5802682 PTPRD cervix,NS,carcinoma,adenocarcinoma c.3530G>A p.R1177H 9:8465650-8465650 24
15 COSM5154 PTEN cervix,NS,carcinoma,adenocarcinoma c.697C>T p.R233* 10:87957915-87957915 24
16 COSM5219 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>G p.R130G 10:87933147-87933147 24
17 COSM5056 PTEN cervix,NS,carcinoma,adenocarcinoma c.1093G>A p.V365I 10:87965353-87965353 24
18 COSM5152 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>T p.R130* 10:87933147-87933147 24
19 COSM88109 PTEN cervix,NS,carcinoma,adenocarcinoma c.724G>T p.E242* 10:87957942-87957942 24
20 COSM27133 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>C p.E545Q 3:179218303-179218303 24
21 COSM6147 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1636C>G p.Q546E 3:179218306-179218306 24
22 COSM763 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>A p.E545K 3:179218303-179218303 24
23 COSM29313 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3129G>A p.M1043I 3:179234286-179234286 24
24 COSM760 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3:179218294-179218294 24
25 COSM24712 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1638G>T p.Q546H 3:179218308-179218308 24
26 COSM775 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3140A>G p.H1047R 3:179234297-179234297 24
27 COSM759 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1616C>G p.P539R 3:179218286-179218286 24
28 COSM12584 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1357G>A p.E453K 3:179210291-179210291 24
29 COSM746 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.263G>A p.R88Q 3:179199088-179199088 24
30 COSM584 NRAS cervix,NS,carcinoma,adenocarcinoma c.182A>G p.Q61R 1:114713908-114713908 24
31 COSM521 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 12:25245350-25245350 24
32 COSM522 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>C p.G12A 12:25245350-25245350 24
33 COSM517 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 12:25245351-25245351 24
34 COSM532 KRAS cervix,NS,carcinoma,adenocarcinoma c.38G>A p.G13D 12:25245347-25245347 24
35 COSM516 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>T p.G12C 12:25245351-25245351 24
36 COSM520 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>T p.G12V 12:25245350-25245350 24
37 COSM551 KRAS cervix,NS,carcinoma,adenocarcinoma c.182A>C p.Q61P 12:25227342-25227342 24
38 COSM555 KRAS cervix,NS,carcinoma,adenocarcinoma c.183A>T p.Q61H 12:25227341-25227341 24
39 COSM518 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>C p.G12R 12:25245351-25245351 24
40 COSM546 KRAS cervix,NS,carcinoma,adenocarcinoma c.175G>A p.A59T 12:25227349-25227349 24
41 COSM96324 KEAP1 cervix,NS,carcinoma,adenocarcinoma c.778C>T p.R260* 19:10492124-10492124 24
42 COSM480 HRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 11:534289-534289 24
43 COSM5945795 GNA11 cervix,NS,carcinoma,adenocarcinoma c.972C>G p.I324M 19:3121071-3121071 24
44 COSM420169 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1436G>C p.R479P 4:152326214-152326214 24
45 COSM22932 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1393C>T p.R465C 4:152328233-152328233 24
46 COSM22975 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1513C>T p.R505C 4:152326137-152326137 24
47 COSM94225 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.929C>A p.S310Y 17:39711955-39711955 24
48 COSM5049502 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.2260G>A p.V754M 17:39723963-39723963 24
49 COSM48358 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.929C>T p.S310F 17:39711955-39711955 24
50 COSM6937049 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.2183C>T p.S728F 17:39723635-39723635 24

Expression for Glassy Cell Carcinoma of the Cervix

Search GEO for disease gene expression data for Glassy Cell Carcinoma of the Cervix.

Pathways for Glassy Cell Carcinoma of the Cervix

Pathways related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.8 PGR ESR1 ERBB2
2
Show member pathways
11.73 ESR1 ERBB2
3 11.68 ESR1 ERBB2
4
Show member pathways
11.57 PGR ESR1
5
Show member pathways
11.23 ESR1 ERBB2
6
Show member pathways
11.11 PGR ESR1
7
Show member pathways
10.83 PGR ESR1 ERBB2

GO Terms for Glassy Cell Carcinoma of the Cervix

Biological processes related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.16 PGR ESR1
2 transcription, DNA-templated GO:0006351 8.96 ESR1
3 positive regulation of protein kinase B signaling GO:0051897 8.96 ESR1 ERBB2
4 steroid hormone mediated signaling pathway GO:0043401 8.62 PGR ESR1

Molecular functions related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 PGR ESR1 ERBB2
2 ATPase binding GO:0051117 9.26 PGR ESR1
3 steroid hormone receptor activity GO:0003707 9.16 PGR ESR1
4 nuclear receptor activity GO:0004879 8.96 PGR ESR1
5 steroid binding GO:0005496 8.62 PGR ESR1

Sources for Glassy Cell Carcinoma of the Cervix

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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