Glassy Cell Carcinoma of the Cervix disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GLS012 MIFTS: 31	Glassy Cell Carcinoma of the Cervix Categories: Cancer diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Glassy Cell Carcinoma of the Cervix

MalaCards integrated aliases for Glassy Cell Carcinoma of the Cervix:

Name: Glassy Cell Carcinoma of the Cervix ⁵²

Glassy Cell Adenocarcinoma of the Uterine Cervix ⁵²

Gcc of the Cervix ⁵²

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases

See all MalaCards categories (disease lists)

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Summaries for Glassy Cell Carcinoma of the Cervix

MalaCards based summary : Glassy Cell Carcinoma of the Cervix, also known as glassy cell adenocarcinoma of the uterine cervix, is related to cervical adenocarcinoma and mucinous adenocarcinoma. An important gene associated with Glassy Cell Carcinoma of the Cervix is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gastric cancer and Development Ligand-independent activation of ESR1 and ESR2. Affiliated tissues include cervix and ovary, and related phenotypes are limbs/digits/tail and neoplasm

Wikipedia : ⁷⁴ Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour... more...

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Related Diseases for Glassy Cell Carcinoma of the Cervix

Diseases related to Glassy Cell Carcinoma of the Cervix via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)

#	Related Disease	Score	Top Affiliating Genes
1	cervical adenocarcinoma	29.5	PGR ESR1 ERBB2
2	mucinous adenocarcinoma	29.3	PGR ESR1 ERBB2
3	glassy cell carcinoma of the cervix uteri	12.7
4	cervical cancer	10.5
5	adenosquamous carcinoma	10.5
6	suppressor of tumorigenicity 3	10.3
7	large cell carcinoma	10.3
8	adenocarcinoma	10.2
9	appendix adenocarcinoma	10.2
10	keratinizing squamous cell carcinoma	10.2
11	rare tumor	10.2
12	bartholin's gland adenoid cystic carcinoma	10.0	PGR ESR1
13	chronic tympanitis	10.0	PGR ESR1
14	bartholin's gland adenoma	10.0	PGR ESR1
15	granulomatous endometritis	10.0	PGR ESR1
16	endometritis	10.0	PGR ESR1
17	bartholin's gland benign neoplasm	10.0	PGR ESR1
18	vestibular gland benign neoplasm	10.0	PGR ESR1
19	uterine corpus adenosarcoma	10.0	PGR ESR1
20	vaginal glandular tumor	10.0	PGR ESR1
21	lung leiomyoma	10.0	PGR ESR1
22	leiomyoma	10.0	PGR ESR1
23	myoma	10.0	PGR ESR1
24	vulvar syringoma	10.0	PGR ESR1
25	trigonitis	10.0	PGR ESR1
26	cervical clear cell adenocarcinoma	10.0	PGR ESR1
27	adult type testicular granulosa cell tumor	10.0	PGR ESR1
28	ovarian seromucinous carcinoma	10.0	PGR ESR1
29	liver leiomyoma	10.0	PGR ESR1
30	intravenous leiomyomatosis	10.0	PGR ESR1
31	leiomyomatosis	10.0	PGR ESR1
32	mammographic density	10.0	PGR ESR1
33	bizarre leiomyoma	10.0	PGR ESR1
34	vulvar leiomyoma	10.0	PGR ESR1
35	progesterone resistance	9.9	PGR ESR1
36	urethral benign neoplasm	9.9	PGR ESR1
37	biphasic synovial sarcoma	9.9	PGR ESR1
38	vaginal endometrial stromal sarcoma	9.9	PGR ESR1
39	endometrial stromal sarcoma	9.9	PGR ESR1
40	juvenile nasopharyngeal angiofibroma	9.9	PGR ESR1
41	adenomyoma	9.9	PGR ESR1
42	vagina sarcoma	9.9	PGR ESR1
43	gender identity disorder	9.9	PGR ESR1
44	vaginal cancer	9.9	PGR ESR1
45	estrogen excess	9.9	PGR ESR1
46	vaginal discharge	9.9	PGR ESR1
47	endometriosis of ovary	9.9	PGR ESR1
48	endometrial disease	9.9	PGR ESR1
49	prostatic hypertrophy	9.9	PGR ESR1
50	smooth muscle tumor	9.9	PGR ESR1

Graphical network of the top 20 diseases related to Glassy Cell Carcinoma of the Cervix:

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Symptoms & Phenotypes for Glassy Cell Carcinoma of the Cervix

MGI Mouse Phenotypes related to Glassy Cell Carcinoma of the Cervix:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail	MP:0005371	9.13	ERBB2 ESR1 PGR
2	neoplasm	MP:0002006	8.8	ERBB2 ESR1 PGR

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Drugs & Therapeutics for Glassy Cell Carcinoma of the Cervix

Search Clinical Trials , NIH Clinical Center for Glassy Cell Carcinoma of the Cervix

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Genetic Tests for Glassy Cell Carcinoma of the Cervix

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Anatomical Context for Glassy Cell Carcinoma of the Cervix

MalaCards organs/tissues related to Glassy Cell Carcinoma of the Cervix:

⁴⁰

Cervix, Ovary

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Publications for Glassy Cell Carcinoma of the Cervix

Articles related to Glassy Cell Carcinoma of the Cervix:

(show all 31)

#	Title	Authors	PMID	Year
1	[Glassy cell carcinoma of the uterine cervix: An aggressive type of cancer]. ⁶¹	Montagner C...Lidove O	31431320	2019
2	Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications. ⁶¹	McEachron TA...Torno LR	26974246	2016
3	Glassy cell carcinoma of the cervix and metastasis in episiotomy scar: a case report. ⁶¹	Carocha AI...Jorge AF	25062402	2015
4	[Glassy cell carcinoma of the cervix: report of a case and literature review]. ⁶¹	Hakimi I...Dehayni M	26664556	2015
5	Glassy cell carcinoma of the cervix: a literature review. ⁶¹	Zolciak-Siwinska A...Jonska-Gmyrek J	24792540	2014
6	[Glassy cell carcinoma: a rare cervical neoplasm. Case report of two patients and review of the literature]. ⁶¹	Lepinoy A...Servagi-Vernat S	24819246	2014
7	Glassy cell carcinoma of the cervix: a systematic review and meta-analysis. ⁶¹	Guitarte C...Lee YC	24503463	2014
8	Glassy cell carcinoma of the cervix--a case report with review of the literature. ⁶¹	Kosiniska-Kaczynska K...Wielgos M	22384631	2011
9	Conservatively treated glassy cell carcinoma of the cervix. ⁶¹	Ferrandina G...Scambia G	18755015	2008
10	Glassy cell carcinoma of the cervix: cytologic features and expression of estrogen receptor, progesterone receptor and Her2/neu protein. ⁶¹	Kuroda H...Itoyama S	16901007	2006
11	Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature. ⁶¹	Deshpande AH...Bobhate SK	15318016	2004
12	Glassy cell adenocarcinoma of the uterine cervix. ⁶¹	Hopkins MP...Morley GW	14749637	2004
13	Liquid-based cytology findings of glassy cell carcinoma of the cervix. Report of a case with histologic correlation and molecular analysis. ⁶¹	Ng WK...Li AS	14969191	2004
14	Can glassy cell carcinoma of the cervix be diagnosed by Pap smear? ⁶¹	Gray JA...Nguyen GK	12462103	2002
15	Glassy cell carcinoma of the cervix revisited. ⁶¹	Gray HJ...Paley PJ	11972387	2002
16	Glassy cell carcinoma of the uterine cervix. Report of a case with cytohistologic and immunohistochemical study. ⁶¹	Reis-Filho JS...Schmitt FC	11393075	2001
17	Response of glassy-cell carcinoma of the cervix to cisplatin, epirubicin, and mitomycin C. ⁶¹	Mikami M...Mukai M	10791384	2000
18	Concomitant irradiation and dose-escalating carboplatin for locally advanced carcinoma of the uterine cervix: an updated report. ⁶¹	Corn BW...Hernandez E	9499253	1998
19	Absence of estrogen and progesterone receptors in glassy cell carcinoma of the cervix. ⁶¹	Atlas I...Steinhoff MM	9464737	1998
20	Glassy cell carcinoma of the cervix: a bimodal treatment strategy. ⁶¹	Lotocki RJ...Fung FK	1541437	1992
21	Stage IB glassy cell carcinoma of the cervix diagnosed during pregnancy and recurring in a transposed ovary. ⁶¹	Reisinger SA...Jahshan A	1916516	1991
22	[Glassy cell carcinoma of the cervix]. ⁶¹	Dieterle S...Kuhnle H	1909675	1991
23	Glassy cell carcinoma of the endometrium. ⁶¹	Hachisuga T...Nakano H	1688542	1990
24	Glassy cell carcinoma of the cervix redefined. ⁶¹	Tamimi HK...Greer BE	3368169	1988
25	Glassy cell carcinoma of the cervix. Cytologic and clinicopathologic analysis. ⁶¹	Pak HY...Agliozzo CM	6861073	1983
26	Glassy cell carcinoma of the cervix. ⁶¹	Maier RC...Norris HJ	6296737	1982
27	Glassy cell carcinoma of the cervix: report of three cases. ⁶¹	Johnston GA...Jones HA	7120471	1982
28	A clinicopathological study on glassy cell carcinoma of the cervix. ⁶¹	Tsukahara Y...Fukuta T	7234357	1981
29	Glassy-cell carcinoma of the cervix: case report with a light and electron microscopy study. ⁶¹	Paulsen SM...Nielsen VT	7233592	1980
30	Stage i B glassy cell carcinoma of the cervix with ovarian metastases. ⁶¹	Nahhas WA...Mortel R	858556	1977
31	Glassy cell carcinoma of the cervix. ⁶¹	Littman P...Scully RE	1260713	1976

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Genes for Glassy Cell Carcinoma of the Cervix

Genes related to Glassy Cell Carcinoma of the Cervix (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PGR	Progesterone Receptor	Protein Coding	6.99	GeneCards inferred via : Publications (show sections)
2	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	6.64	GeneCards inferred via : Publications (show sections)
3	ESR1	Estrogen Receptor 1	Protein Coding	6.64	GeneCards inferred via : Publications (show sections)

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Variations for Glassy Cell Carcinoma of the Cervix

Cosmic variations for Glassy Cell Carcinoma of the Cervix:

⁹ (show top 50) (show all 305)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM87935416	TP53	cervix,NS,carcinoma,adenocarcinoma	c.499C>T	p.Q167*	17:7675113-7675113	15
2	COSM87898709	TP53	cervix,NS,carcinoma,adenocarcinoma	c.742C>T	p.R248W	17:7674221-7674221	15
3	COSM88037566	TP53	cervix,NS,carcinoma,adenocarcinoma	c.677G>T	p.G226V	17:7674286-7674286	15
4	COSM87897839	TP53	cervix,NS,carcinoma,adenocarcinoma	c.701A>G	p.Y234C	17:7674262-7674262	15
5	COSM87898351	TP53	cervix,NS,carcinoma,adenocarcinoma	c.743G>A	p.R248Q	17:7674220-7674220	15
6	COSM90696350	STK11	cervix,NS,carcinoma,adenocarcinoma	c.894C>A	p.F298L	19:1221980-1221980	15
7	COSM90691877	STK11	cervix,NS,carcinoma,adenocarcinoma	c.910C>T	p.R304W	19:1221996-1221996	15
8	COSM96847086	PTEN	cervix,NS,carcinoma,adenocarcinoma	c.724G>T	p.E242*	10:87957942-87957942	15
9	COSM96860667	PTEN	cervix,NS,carcinoma,adenocarcinoma	c.1093G>A	p.V365I	10:87965353-87965353	15
10	COSM96843054	PTEN	cervix,NS,carcinoma,adenocarcinoma	c.697C>T	p.R233*	10:87957915-87957915	15
11	COSM96842497	PTEN	cervix,NS,carcinoma,adenocarcinoma	c.388C>T	p.R130*	10:87933147-87933147	15
12	COSM96842299	PTEN	cervix,NS,carcinoma,adenocarcinoma	c.388C>G	p.R130G	10:87933147-87933147	15
13	COSM87132301	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1624G>A	p.E542K	3:179218294-179218294	15
14	COSM87132308	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1633G>A	p.E545K	3:179218303-179218303	15
15	COSM87132431	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.3129G>A	p.M1043I	3:179234286-179234286	15
16	COSM87132245	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.3140A>G	p.H1047R	3:179234297-179234297	15
17	COSM87138932	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1636C>G	p.Q546E	3:179218306-179218306	15
18	COSM87133231	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.263G>A	p.R88Q	3:179199088-179199088	15
19	COSM87135718	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1633G>C	p.E545Q	3:179218303-179218303	15
20	COSM87139841	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1638G>T	p.Q546H	3:179218308-179218308	15
21	COSM87134376	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1616C>G	p.P539R	3:179218286-179218286	15
22	COSM87133243	PIK3CA	cervix,NS,carcinoma,adenocarcinoma	c.1357G>A	p.E453K	3:179210291-179210291	15
23	COSM97107359	NRAS	cervix,NS,carcinoma,adenocarcinoma	c.182A>G	p.Q61R	1:114713908-114713908	15
24	COSM87804075	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.34G>T	p.G12C	12:25245351-25245351	15
25	COSM87804005	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.35G>A	p.G12D	12:25245350-25245350	15
26	COSM87804028	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.38G>A	p.G13D	12:25245347-25245347	15
27	COSM87804068	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.34G>A	p.G12S	12:25245351-25245351	15
28	COSM87804083	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.35G>C	p.G12A	12:25245350-25245350	15
29	COSM87805382	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.175G>A	p.A59T	12:25227349-25227349	15
30	COSM87805356	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.183A>T	p.Q61H	12:25227341-25227341	15
31	COSM87810371	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.182A>C	p.Q61P	12:25227342-25227342	15
32	COSM87804055	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.35G>T	p.G12V	12:25245350-25245350	15
33	COSM87804155	KRAS	cervix,NS,carcinoma,adenocarcinoma	c.34G>C	p.G12R	12:25245351-25245351	15
34	COSM112989371	HRAS	cervix,NS,carcinoma,adenocarcinoma	c.34G>A	p.G12S	11:534289-534289	15
35	COSM84064156	GNA11	cervix,NS,carcinoma,adenocarcinoma	c.972C>G	p.I324M	19:3121071-3121071	15
36	COSM141955806	FBXW7	cervix,NS,carcinoma,adenocarcinoma	c.1436G>C	p.R479P	4:152326214-152326214	15
37	COSM141953409	FBXW7	cervix,NS,carcinoma,adenocarcinoma	c.1513C>T	p.R505C	4:152326137-152326137	15
38	COSM88595036	ERBB2	cervix,NS,carcinoma,adenocarcinoma	c.2260G>A	p.V754M	17:39723963-39723963	15
39	COSM88585849	ERBB2	cervix,NS,carcinoma,adenocarcinoma	c.929C>T	p.S310F	17:39711955-39711955	15
40	COSM88586417	ERBB2	cervix,NS,carcinoma,adenocarcinoma	c.2524G>A	p.V842I	17:39725079-39725079	15
41	COSM88586423	ERBB2	cervix,NS,carcinoma,adenocarcinoma	c.929C>A	p.S310Y	17:39711955-39711955	15
42	COSM150913532	CTNNB1	cervix,NS,carcinoma,adenocarcinoma	c.110C>T	p.S37F	3:41224622-41224622	15
43	COSM150914055	CTNNB1	cervix,NS,carcinoma,adenocarcinoma	c.97T>G	p.S33A	3:41224609-41224609	15
44	COSM150580638	BRAF	cervix,NS,carcinoma,adenocarcinoma	c.1787G>A	p.G596D	7:140753348-140753348	15
45	COSM150564063	BRAF	cervix,NS,carcinoma,adenocarcinoma	c.1397G>T	p.G466V	7:140781611-140781611	15
46	COSM150587390	BRAF	cervix,NS,carcinoma,adenocarcinoma	c.1789C>G	p.L597V	7:140753346-140753346	15
47	COSM150567521	BRAF	cervix,NS,carcinoma,adenocarcinoma	c.1406G>A	p.G469E	7:140781602-140781602	15
48	COSM88129409	ATM	cervix,NS,carcinoma,adenocarcinoma	c.7322T>G	p.V2441G	11:108330228-108330228	15
49	COSM99448653	ALK	cervix,NS,carcinoma,adenocarcinoma	c.1396G>A	p.D466N	2:29328368-29328368	15
50	COSM148932717		cervix,NS,carcinoma,adenocarcinoma	c.1624G>A	p.E542K	3:179218294-179218294	15

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Expression for Glassy Cell Carcinoma of the Cervix

Search GEO for disease gene expression data for Glassy Cell Carcinoma of the Cervix.

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Pathways for Glassy Cell Carcinoma of the Cervix

Pathways related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	11.8	PGR ESR1 ERBB2
2	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	11.73	ESR1 ERBB2
3	Proteoglycans in cancer ³⁶	11.68	ESR1 ERBB2
4	Cell cycle Role of SCF complex in cell cycle regulation ²² Show member pathways Cell cycle ESR1 regulation of G1/S transition ²² Cell cycle Regulation of G1/S transition (part 1) ²² Immune response MIF-JAB1 signaling ²²	11.57	PGR ESR1
5	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁵ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁵ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁵ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁵ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁵ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁵ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁵	11.23	ESR1 ERBB2
6	Nuclear Receptor transcription pathway ⁶⁵ Show member pathways Nuclear Receptors ¹	11.11	PGR ESR1
7	Signaling by ERBB4 ⁶⁵ Show member pathways Downregulation of ERBB4 signaling ⁶⁵ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁵	10.83	PGR ESR1 ERBB2

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GO Terms for Glassy Cell Carcinoma of the Cervix

Cellular components related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	host cell nucleus	GO:0042025	8.62	PGR ESR1

Biological processes related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of protein kinase B signaling	GO:0051897	9.16	ESR1 ERBB2
2	transcription initiation from RNA polymerase II promoter	GO:0006367	8.96	PGR ESR1
3	steroid hormone mediated signaling pathway	GO:0043401	8.62	PGR ESR1

Molecular functions related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.54	PGR ESR1 ERBB2
2	ATPase binding	GO:0051117	9.32	PGR ESR1
3	steroid hormone receptor activity	GO:0003707	9.26	PGR ESR1
4	repressing transcription factor binding	GO:0070491	9.16	PGR ESR1
5	nuclear receptor activity	GO:0004879	8.96	PGR ESR1
6	steroid binding	GO:0005496	8.62	PGR ESR1

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Sources for Glassy Cell Carcinoma of the Cervix

¹ BioSystems

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²³ GeneHancer via GeneCards

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²⁵ Genetics Home Reference

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³³ ICD10 via Orphanet

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⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

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⁵⁹ PathCards

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⁶¹ PubMed

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⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia