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MCID: GLS012
MIFTS: 29

Glassy Cell Carcinoma of the Cervix

Categories: Rare diseases, Cancer diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Glassy Cell Carcinoma of the Cervix

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MalaCards integrated aliases for Glassy Cell Carcinoma of the Cervix:

Name: Glassy Cell Carcinoma of the Cervix 53
Glassy Cell Adenocarcinoma of the Uterine Cervix 53
Gcc of the Cervix 53

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
See all MalaCards categories (disease lists)


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Summaries for Glassy Cell Carcinoma of the Cervix

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MalaCards based summary : Glassy Cell Carcinoma of the Cervix, also known as glassy cell adenocarcinoma of the uterine cervix, is related to glassy cell carcinoma of the cervix uteri and vulvar syringoma. An important gene associated with Glassy Cell Carcinoma of the Cervix is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gastric cancer and Development Ligand-independent activation of ESR1 and ESR2. Affiliated tissues include cervix and ovary, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : 76 Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour... more...

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Related Diseases for Glassy Cell Carcinoma of the Cervix

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Diseases related to Glassy Cell Carcinoma of the Cervix via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 glassy cell carcinoma of the cervix uteri 12.3
2 vulvar syringoma 10.2 ESR1 PGR
3 lung leiomyoma 10.2 ESR1 PGR
4 vestibular gland benign neoplasm 10.2 ESR1 PGR
5 bartholin's gland adenoma 10.2 ESR1 PGR
6 vulvar benign neoplasm 10.2 ESR1 PGR
7 trigonitis 10.2 ESR1 PGR
8 vulvar leiomyoma 10.2 ESR1 PGR
9 predominantly cortical thymoma 10.1 ESR1 PGR
10 progesterone resistance 10.1 ESR1 PGR
11 cribriform carcinoma 10.1 ESR1 PGR
12 endometrial squamous cell carcinoma 10.1 ESR1 PGR
13 gastric signet ring cell adenocarcinoma 10.1 ESR1 PGR
14 endometrial mucinous adenocarcinoma 10.1 ESR1 PGR
15 adenoid basal cell carcinoma 10.1 ESR1 PGR
16 gender identity disorder 10.1 ESR1 PGR
17 bartholin's gland benign neoplasm 10.1 ESR1 PGR
18 deep angioma 10.1 ESR1 PGR
19 synchronous bilateral breast carcinoma 10.1 ESR1 PGR
20 cervical carcinosarcoma 10.1 ESR1 PGR
21 estrogen excess 10.1 ESR1 PGR
22 intramuscular hemangioma 10.1 ESR1 PGR
23 glycogen-rich clear cell breast carcinoma 10.1 ESR1 PGR
24 mammographic density 10.1 ESR1 PGR
25 retinitis pigmentosa 47 10.1 ESR1 PGR
26 adenomyosis 10.1 ESR1 PGR
27 retinitis pigmentosa 20 10.1 ESR1 PGR
28 adenosarcoma 10.1 ESR1 PGR
29 cervical clear cell adenocarcinoma 10.1 ESR1 PGR
30 endometriosis of ovary 10.1 ESR1 PGR
31 uterine benign neoplasm 10.1 ESR1 PGR
32 reproductive organ benign neoplasm 10.1 ESR1 PGR
33 smooth muscle tumor 10.1 ESR1 PGR
34 pancreatic mucinous cystadenoma 10.0 ESR1 PGR
35 endometritis 10.0 ESR1 PGR
36 prostatic hypertrophy 10.0 ESR1 PGR
37 peritoneal mesothelioma 10.0 ESR1 PGR
38 pelvic organ prolapse 10.0 ESR1 PGR
39 juvenile nasopharyngeal angiofibroma 10.0 ESR1 PGR
40 angiomyolipoma 10.0 ESR1 PGR
41 leiomyomatosis 10.0 ESR1 PGR
42 gynecomastia 10.0 ESR1 PGR
43 female reproductive system disease 9.9 ESR1 PGR
44 comedo carcinoma 9.9 ERBB2 ESR1
45 myoma 9.9 ESR1 PGR
46 reproductive system disease 9.9 ESR1 PGR
47 lymphangioleiomyomatosis 9.8 ESR1 PGR
48 lobular neoplasia 9.8 ERBB2 ESR1
49 scirrhous adenocarcinoma 9.8 ERBB2 PGR
50 breast apocrine carcinoma 9.8 ERBB2 PGR

Graphical network of the top 20 diseases related to Glassy Cell Carcinoma of the Cervix:



Diseases related to Glassy Cell Carcinoma of the Cervix
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Symptoms & Phenotypes for Glassy Cell Carcinoma of the Cervix

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MGI Mouse Phenotypes related to Glassy Cell Carcinoma of the Cervix:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.33 ERBB2 ESR1 PGR
2 muscle MP:0005369 9.13 ERBB2 ESR1 PGR
3 neoplasm MP:0002006 8.8 ERBB2 ESR1 PGR
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Drugs & Therapeutics for Glassy Cell Carcinoma of the Cervix

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Search Clinical Trials , NIH Clinical Center for Glassy Cell Carcinoma of the Cervix

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Genetic Tests for Glassy Cell Carcinoma of the Cervix

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Anatomical Context for Glassy Cell Carcinoma of the Cervix

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MalaCards organs/tissues related to Glassy Cell Carcinoma of the Cervix:

41
Cervix, Ovary
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Publications for Glassy Cell Carcinoma of the Cervix

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Articles related to Glassy Cell Carcinoma of the Cervix:

(show all 22)
# Title Authors Year
1
Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications. ( 26974246 )
2016
2
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis. ( 24503463 )
2014
3
Glassy cell carcinoma of the cervix: a literature review. ( 24792540 )
2014
4
Glassy Cell Carcinoma of the Cervix and Metastasis in Episiotomy Scar: A Case Report. ( 25062402 )
2014
5
Glassy cell carcinoma of the cervix--a case report with review of the literature. ( 22384631 )
2011
6
Conservatively treated glassy cell carcinoma of the cervix. ( 18755015 )
2008
7
Glassy cell carcinoma of the cervix: cytologic features and expression of estrogen receptor, progesterone receptor and Her2/neu protein. ( 16901007 )
2006
8
Liquid-based cytology findings of glassy cell carcinoma of the cervix. Report of a case with histologic correlation and molecular analysis. ( 14969191 )
2004
9
Glassy cell carcinoma of the cervix revisited. ( 11972387 )
2002
10
Can glassy cell carcinoma of the cervix be diagnosed by Pap smear? ( 12462103 )
2002
11
Response of glassy-cell carcinoma of the cervix to cisplatin, epirubicin, and mitomycin C. ( 10791384 )
2000
12
Absence of estrogen and progesterone receptors in glassy cell carcinoma of the cervix. ( 9464737 )
1998
13
Glassy cell carcinoma of the cervix: a bimodal treatment strategy. ( 1541437 )
1992
14
Stage IB glassy cell carcinoma of the cervix diagnosed during pregnancy and recurring in a transposed ovary. ( 1916516 )
1991
15
Glassy cell carcinoma of the cervix redefined. ( 3368169 )
1988
16
Glassy cell carcinoma of the cervix. Cytologic and clinicopathologic analysis. ( 6861073 )
1983
17
Glassy cell carcinoma of the cervix. ( 6296737 )
1982
18
Glassy cell carcinoma of the cervix: report of three cases. ( 7120471 )
1982
19
A clinicopathological study on glassy cell carcinoma of the cervix. ( 7234357 )
1981
20
Glassy-cell carcinoma of the cervix: case report with a light and electron microscopy study. ( 7233592 )
1980
21
Stage i B glassy cell carcinoma of the cervix with ovarian metastases. ( 858556 )
1977
22
Glassy cell carcinoma of the cervix. ( 1260713 )
1976
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Variations for Glassy Cell Carcinoma of the Cervix

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Cosmic variations for Glassy Cell Carcinoma of the Cervix:

9
(show top 50) (show all 83)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM1235014 U2AF1 cervix,NS,carcinoma,adenocarcinoma c.467G>A p.R156H 21:43094670-43094670 15
2 COSM10648 TP53 cervix,NS,carcinoma,adenocarcinoma c.524G>A p.R175H 17:7675088-7675088 15
3 COSM44399 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 15
4 COSM10941 TP53 cervix,NS,carcinoma,adenocarcinoma c.730G>A p.G244S 17:7674233-7674233 15
5 COSM10725 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 15
6 COSM10662 TP53 cervix,NS,carcinoma,adenocarcinoma c.743G>A p.R248Q 17:7674220-7674220 15
7 COSM11333 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 17:7675113-7675113 15
8 COSM10656 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 15
9 COSM29468 STK11 cervix,NS,carcinoma,adenocarcinoma c.910C>T p.R304W 19:1221996-1221996 15
10 COSM29467 STK11 cervix,NS,carcinoma,adenocarcinoma c.894C>A p.F298L 19:1221980-1221980 15
11 COSM6967953 SF3B1 cervix,NS,carcinoma,adenocarcinoma c.1910C>G p.S637C 2:197402723-197402723 15
12 COSM6967952 SF3B1 cervix,NS,carcinoma,adenocarcinoma c.2323C>G p.R775G 2:197401789-197401789 15
13 COSM6923797 RET cervix,NS,carcinoma,adenocarcinoma c.1132G>A p.D378N 10:43109099-43109099 15
14 COSM5802682 PTPRD cervix,NS,carcinoma,adenocarcinoma c.3530G>A p.R1177H 9:8465650-8465650 15
15 COSM5154 PTEN cervix,NS,carcinoma,adenocarcinoma c.697C>T p.R233* 10:87957915-87957915 15
16 COSM5219 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>G p.R130G 10:87933147-87933147 15
17 COSM5056 PTEN cervix,NS,carcinoma,adenocarcinoma c.1093G>A p.V365I 10:87965353-87965353 15
18 COSM5152 PTEN cervix,NS,carcinoma,adenocarcinoma c.388C>T p.R130* 10:87933147-87933147 15
19 COSM88109 PTEN cervix,NS,carcinoma,adenocarcinoma c.724G>T p.E242* 10:87957942-87957942 15
20 COSM29313 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3129G>A p.M1043I 3:179234286-179234286 15
21 COSM27133 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>C p.E545Q 3:179218303-179218303 15
22 COSM6147 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1636C>G p.Q546E 3:179218306-179218306 15
23 COSM763 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1633G>A p.E545K 3:179218303-179218303 15
24 COSM760 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3:179218294-179218294 15
25 COSM24712 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1638G>T p.Q546H 3:179218308-179218308 15
26 COSM775 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.3140A>G p.H1047R 3:179234297-179234297 15
27 COSM759 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1616C>G p.P539R 3:179218286-179218286 15
28 COSM12584 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.1357G>A p.E453K 3:179210291-179210291 15
29 COSM746 PIK3CA cervix,NS,carcinoma,adenocarcinoma c.263G>A p.R88Q 3:179199088-179199088 15
30 COSM584 NRAS cervix,NS,carcinoma,adenocarcinoma c.182A>G p.Q61R 1:114713908-114713908 15
31 COSM517 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 12:25245351-25245351 15
32 COSM521 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>A p.G12D 12:25245350-25245350 15
33 COSM532 KRAS cervix,NS,carcinoma,adenocarcinoma c.38G>A p.G13D 12:25245347-25245347 15
34 COSM522 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>C p.G12A 12:25245350-25245350 15
35 COSM516 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>T p.G12C 12:25245351-25245351 15
36 COSM520 KRAS cervix,NS,carcinoma,adenocarcinoma c.35G>T p.G12V 12:25245350-25245350 15
37 COSM551 KRAS cervix,NS,carcinoma,adenocarcinoma c.182A>C p.Q61P 12:25227342-25227342 15
38 COSM555 KRAS cervix,NS,carcinoma,adenocarcinoma c.183A>T p.Q61H 12:25227341-25227341 15
39 COSM518 KRAS cervix,NS,carcinoma,adenocarcinoma c.34G>C p.G12R 12:25245351-25245351 15
40 COSM96324 KEAP1 cervix,NS,carcinoma,adenocarcinoma c.778C>T p.R260* 19:10492124-10492124 15
41 COSM480 HRAS cervix,NS,carcinoma,adenocarcinoma c.34G>A p.G12S 11:534289-534289 15
42 COSM5945795 GNA11 cervix,NS,carcinoma,adenocarcinoma c.972C>G p.I324M 19:3121071-3121071 15
43 COSM420169 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1436G>C p.R479P 4:152326214-152326214 15
44 COSM22932 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1393C>T p.R465C 4:152328233-152328233 15
45 COSM22975 FBXW7 cervix,NS,carcinoma,adenocarcinoma c.1513C>T p.R505C 4:152326137-152326137 15
46 COSM6937049 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.2183C>T p.S728F 17:39723635-39723635 15
47 COSM48358 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.929C>T p.S310F 17:39711955-39711955 15
48 COSM94225 ERBB2 cervix,NS,carcinoma,adenocarcinoma c.929C>A p.S310Y 17:39711955-39711955 15
49 COSM5662 CTNNB1 cervix,NS,carcinoma,adenocarcinoma c.110C>T p.S37F 3:41224622-41224622 15
50 COSM5683 CTNNB1 cervix,NS,carcinoma,adenocarcinoma c.97T>G p.S33A 3:41224609-41224609 15
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Expression for Glassy Cell Carcinoma of the Cervix

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Search GEO for disease gene expression data for Glassy Cell Carcinoma of the Cervix.
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Pathways for Glassy Cell Carcinoma of the Cervix

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Pathways related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Gastric cancer 37
Show member pathways
 11.8 ERBB2 ESR1 PGR
2
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 11.73 ERBB2 ESR1
3
Proteoglycans in cancer 37
11.67 ERBB2 ESR1
4
Cell cycle Role of SCF complex in cell cycle regulation 22
Show member pathways
 11.57 ESR1 PGR
5
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 66
Show member pathways
 11.23 ERBB2 ESR1
6
Nuclear Receptor transcription pathway 66
Show member pathways
 11.11 ESR1 PGR
7
Signaling by ERBB4 66
Show member pathways
 10.83 ERBB2 ESR1 PGR
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GO Terms for Glassy Cell Carcinoma of the Cervix

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Biological processes related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.32 ESR1 PGR
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.26 ESR1 PGR
3 positive regulation of protein kinase B signaling GO:0051897 9.16 ERBB2 ESR1
4 phosphatidylinositol phosphorylation GO:0046854 8.96 ERBB2 ESR1
5 steroid hormone mediated signaling pathway GO:0043401 8.62 ESR1 PGR

Molecular functions related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.54 ERBB2 ESR1 PGR
2 ATPase binding GO:0051117 9.32 ESR1 PGR
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 ERBB2 ESR1
4 steroid hormone receptor activity GO:0003707 9.16 ESR1 PGR
5 nuclear receptor activity GO:0004879 8.96 ESR1 PGR
6 steroid binding GO:0005496 8.62 ESR1 PGR
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Sources for Glassy Cell Carcinoma of the Cervix

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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