MCID: GLS012
MIFTS: 30

Glassy Cell Carcinoma of the Cervix

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Glassy Cell Carcinoma of the Cervix

MalaCards integrated aliases for Glassy Cell Carcinoma of the Cervix:

Name: Glassy Cell Carcinoma of the Cervix 20
Glassy Cell Adenocarcinoma of the Uterine Cervix 20
Gcc of the Cervix 20

Classifications:



Summaries for Glassy Cell Carcinoma of the Cervix

MalaCards based summary : Glassy Cell Carcinoma of the Cervix, also known as glassy cell adenocarcinoma of the uterine cervix, is related to cervical adenocarcinoma and mucinous adenocarcinoma. An important gene associated with Glassy Cell Carcinoma of the Cervix is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gastric cancer and Development Ligand-independent activation of ESR1 and ESR2. Affiliated tissues include cervix and ovary, and related phenotypes are limbs/digits/tail and neoplasm

Wikipedia : 73 Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour... more...

Related Diseases for Glassy Cell Carcinoma of the Cervix

Diseases related to Glassy Cell Carcinoma of the Cervix via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 cervical adenocarcinoma 30.3 ESR1 ERBB2
2 mucinous adenocarcinoma 29.7 PGR ESR1 ERBB2
3 glassy cell carcinoma of the cervix uteri 11.5
4 adenosquamous carcinoma 10.6
5 suppressor of tumorigenicity 3 10.4
6 large cell carcinoma 10.4
7 cervical cancer 10.2
8 adenocarcinoma 10.2
9 appendix adenocarcinoma 10.2
10 keratinizing squamous cell carcinoma 10.2
11 rare tumor 10.2
12 bartholin's gland adenoma 10.0 PGR ESR1
13 bartholin's gland adenoid cystic carcinoma 10.0 PGR ESR1
14 uterine corpus adenosarcoma 10.0 PGR ESR1
15 bartholin's gland benign neoplasm 10.0 PGR ESR1
16 chronic tympanitis 10.0 PGR ESR1
17 vestibular gland benign neoplasm 10.0 PGR ESR1
18 granulomatous endometritis 10.0 PGR ESR1
19 endometritis 10.0 PGR ESR1
20 vulvar syringoma 10.0 PGR ESR1
21 lung leiomyoma 10.0 PGR ESR1
22 leiomyoma 10.0 PGR ESR1
23 myoma 10.0 PGR ESR1
24 adult type testicular granulosa cell tumor 10.0 PGR ESR1
25 cervical clear cell adenocarcinoma 10.0 PGR ESR1
26 ovarian seromucinous carcinoma 10.0 PGR ESR1
27 liver leiomyoma 10.0 PGR ESR1
28 intravenous leiomyomatosis 10.0 PGR ESR1
29 leiomyomatosis 10.0 PGR ESR1
30 intracranial meningioma 10.0 PGR ESR1
31 vulvar leiomyoma 10.0 PGR ESR1
32 bizarre leiomyoma 10.0 PGR ESR1
33 breast adenoma 10.0 PGR ESR1
34 prostate stromal sarcoma 10.0 PGR ESR1
35 urethral benign neoplasm 10.0 PGR ESR1
36 cervical adenosarcoma 10.0 PGR ESR1
37 gender identity disorder 10.0 PGR ESR1
38 progesterone resistance 10.0 PGR ESR1
39 biphasic synovial sarcoma 10.0 PGR ESR1
40 vaginal cancer 10.0 PGR ESR1
41 juvenile nasopharyngeal angiofibroma 10.0 PGR ESR1
42 trigonitis 10.0 PGR ESR1
43 vaginal discharge 10.0 PGR ESR1
44 vulvar benign neoplasm 10.0 PGR ESR1
45 ovarian endometrial cancer 10.0 PGR ESR1
46 estrogen excess 10.0 PGR ESR1
47 endometriosis of ovary 10.0 PGR ESR1
48 endometrial disease 10.0 PGR ESR1
49 prostatic hypertrophy 10.0 PGR ESR1
50 smooth muscle tumor 10.0 PGR ESR1

Graphical network of the top 20 diseases related to Glassy Cell Carcinoma of the Cervix:



Diseases related to Glassy Cell Carcinoma of the Cervix

Symptoms & Phenotypes for Glassy Cell Carcinoma of the Cervix

MGI Mouse Phenotypes related to Glassy Cell Carcinoma of the Cervix:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.13 ERBB2 ESR1 PGR
2 neoplasm MP:0002006 8.8 ERBB2 ESR1 PGR

Drugs & Therapeutics for Glassy Cell Carcinoma of the Cervix

Search Clinical Trials , NIH Clinical Center for Glassy Cell Carcinoma of the Cervix

Genetic Tests for Glassy Cell Carcinoma of the Cervix

Anatomical Context for Glassy Cell Carcinoma of the Cervix

MalaCards organs/tissues related to Glassy Cell Carcinoma of the Cervix:

40
Cervix, Ovary

Publications for Glassy Cell Carcinoma of the Cervix

Articles related to Glassy Cell Carcinoma of the Cervix:

(show all 31)
# Title Authors PMID Year
1
[Glassy cell carcinoma of the uterine cervix: An aggressive type of cancer]. 61
31431320 2019
2
Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications. 61
26974246 2016
3
Glassy cell carcinoma of the cervix and metastasis in episiotomy scar: a case report. 61
25062402 2015
4
[Glassy cell carcinoma of the cervix: report of a case and literature review]. 61
26664556 2015
5
Glassy cell carcinoma of the cervix: a literature review. 61
24792540 2014
6
[Glassy cell carcinoma: a rare cervical neoplasm. Case report of two patients and review of the literature]. 61
24819246 2014
7
Glassy cell carcinoma of the cervix: a systematic review and meta-analysis. 61
24503463 2014
8
Glassy cell carcinoma of the cervix--a case report with review of the literature. 61
22384631 2011
9
Conservatively treated glassy cell carcinoma of the cervix. 61
18755015 2008
10
Glassy cell carcinoma of the cervix: cytologic features and expression of estrogen receptor, progesterone receptor and Her2/neu protein. 61
16901007 2006
11
Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature. 61
15318016 2004
12
Glassy cell adenocarcinoma of the uterine cervix. 61
14749637 2004
13
Liquid-based cytology findings of glassy cell carcinoma of the cervix. Report of a case with histologic correlation and molecular analysis. 61
14969191 2004
14
Can glassy cell carcinoma of the cervix be diagnosed by Pap smear? 61
12462103 2002
15
Glassy cell carcinoma of the cervix revisited. 61
11972387 2002
16
Glassy cell carcinoma of the uterine cervix. Report of a case with cytohistologic and immunohistochemical study. 61
11393075 2001
17
Response of glassy-cell carcinoma of the cervix to cisplatin, epirubicin, and mitomycin C. 61
10791384 2000
18
Concomitant irradiation and dose-escalating carboplatin for locally advanced carcinoma of the uterine cervix: an updated report. 61
9499253 1998
19
Absence of estrogen and progesterone receptors in glassy cell carcinoma of the cervix. 61
9464737 1998
20
Glassy cell carcinoma of the cervix: a bimodal treatment strategy. 61
1541437 1992
21
Stage IB glassy cell carcinoma of the cervix diagnosed during pregnancy and recurring in a transposed ovary. 61
1916516 1991
22
[Glassy cell carcinoma of the cervix]. 61
1909675 1991
23
Glassy cell carcinoma of the endometrium. 61
1688542 1990
24
Glassy cell carcinoma of the cervix redefined. 61
3368169 1988
25
Glassy cell carcinoma of the cervix. Cytologic and clinicopathologic analysis. 61
6861073 1983
26
Glassy cell carcinoma of the cervix. 61
6296737 1982
27
Glassy cell carcinoma of the cervix: report of three cases. 61
7120471 1982
28
A clinicopathological study on glassy cell carcinoma of the cervix. 61
7234357 1981
29
Glassy-cell carcinoma of the cervix: case report with a light and electron microscopy study. 61
7233592 1980
30
Stage i B glassy cell carcinoma of the cervix with ovarian metastases. 61
858556 1977
31
Glassy cell carcinoma of the cervix. 61
1260713 1976

Variations for Glassy Cell Carcinoma of the Cervix

Cosmic variations for Glassy Cell Carcinoma of the Cervix:

9 (show top 50) (show all 305)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM144650860 TP53 cervix,NS,carcinoma,adenocarcinoma c.584A>G p.Y195C 17:7674262-7674262 12
2 COSM144651115 TP53 cervix,NS,carcinoma,adenocarcinoma c.626G>A p.R209Q 17:7674220-7674220 12
3 COSM112253879 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 12
4 COSM87935416 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 17:7675113-7675113 12
5 COSM143156843 TP53 cervix,NS,carcinoma,adenocarcinoma c.266G>A p.R89Q 17:7674220-7674220 12
6 COSM111758336 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 12
7 COSM93303215 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 12
8 COSM112374468 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 12
9 COSM111879853 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 12
10 COSM122302302 TP53 cervix,NS,carcinoma,adenocarcinoma c.103C>T p.Q35* 17:7675113-7675113 12
11 COSM143484735 TP53 cervix,NS,carcinoma,adenocarcinoma c.560G>T p.G187V 17:7674286-7674286 12
12 COSM144409660 TP53 cervix,NS,carcinoma,adenocarcinoma c.560G>T p.G187V 17:7674286-7674286 12
13 COSM121910283 TP53 cervix,NS,carcinoma,adenocarcinoma c.103C>T p.Q35* 17:7675113-7675113 12
14 COSM144186978 TP53 cervix,NS,carcinoma,adenocarcinoma c.200G>T p.G67V 17:7674286-7674286 12
15 COSM145045823 TP53 cervix,NS,carcinoma,adenocarcinoma c.382C>T p.Q128* 17:7675113-7675113 12
16 COSM144310429 TP53 cervix,NS,carcinoma,adenocarcinoma c.625C>T p.R209W 17:7674221-7674221 12
17 COSM93183630 TP53 cervix,NS,carcinoma,adenocarcinoma c.743G>A p.R248Q 17:7674220-7674220 12
18 COSM144013367 TP53 cervix,NS,carcinoma,adenocarcinoma c.710G>A p.R237Q 17:7674220-7674220 12
19 COSM106053434 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 12
20 COSM142560012 TP53 cervix,NS,carcinoma,adenocarcinoma c.584A>G p.Y195C 17:7674262-7674262 12
21 COSM122734399 TP53 cervix,NS,carcinoma,adenocarcinoma c.346C>T p.R116W 17:7674221-7674221 12
22 COSM144310011 TP53 cervix,NS,carcinoma,adenocarcinoma c.584A>G p.Y195C 17:7674262-7674262 12
23 COSM93183975 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 12
24 COSM142560553 TP53 cervix,NS,carcinoma,adenocarcinoma c.625C>T p.R209W 17:7674221-7674221 12
25 COSM143370668 TP53 cervix,NS,carcinoma,adenocarcinoma c.584A>G p.Y195C 17:7674262-7674262 12
26 COSM142837551 TP53 cervix,NS,carcinoma,adenocarcinoma c.742C>T p.R248W 17:7674221-7674221 12
27 COSM111790424 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 17:7675113-7675113 12
28 COSM144778606 TP53 cervix,NS,carcinoma,adenocarcinoma c.560G>T p.G187V 17:7674286-7674286 12
29 COSM144111084 TP53 cervix,NS,carcinoma,adenocarcinoma c.22C>T p.Q8* 17:7675113-7675113 12
30 COSM106084061 TP53 cervix,NS,carcinoma,adenocarcinoma c.499C>T p.Q167* 17:7675113-7675113 12
31 COSM143182864 TP53 cervix,NS,carcinoma,adenocarcinoma c.22C>T p.Q8* 17:7675113-7675113 12
32 COSM93183394 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 12
33 COSM112253189 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 12
34 COSM144013181 TP53 cervix,NS,carcinoma,adenocarcinoma c.668A>G p.Y223C 17:7674262-7674262 12
35 COSM144087106 TP53 cervix,NS,carcinoma,adenocarcinoma c.266G>A p.R89Q 17:7674220-7674220 12
36 COSM106172737 TP53 cervix,NS,carcinoma,adenocarcinoma c.677G>T p.G226V 17:7674286-7674286 12
37 COSM122002786 TP53 cervix,NS,carcinoma,adenocarcinoma c.281G>T p.G94V 17:7674286-7674286 12
38 COSM143157019 TP53 cervix,NS,carcinoma,adenocarcinoma c.265C>T p.R89W 17:7674221-7674221 12
39 COSM144087273 TP53 cervix,NS,carcinoma,adenocarcinoma c.265C>T p.R89W 17:7674221-7674221 12
40 COSM144310203 TP53 cervix,NS,carcinoma,adenocarcinoma c.626G>A p.R209Q 17:7674220-7674220 12
41 COSM142592590 TP53 cervix,NS,carcinoma,adenocarcinoma c.382C>T p.Q128* 17:7675113-7675113 12
42 COSM143401670 TP53 cervix,NS,carcinoma,adenocarcinoma c.382C>T p.Q128* 17:7675113-7675113 12
43 COSM142679858 TP53 cervix,NS,carcinoma,adenocarcinoma c.560G>T p.G187V 17:7674286-7674286 12
44 COSM143944147 TP53 cervix,NS,carcinoma,adenocarcinoma c.265C>T p.R89W 17:7674221-7674221 12
45 COSM122859540 TP53 cervix,NS,carcinoma,adenocarcinoma c.281G>T p.G94V 17:7674286-7674286 12
46 COSM105619985 TP53 cervix,NS,carcinoma,adenocarcinoma c.701A>G p.Y234C 17:7674262-7674262 12
47 COSM145017944 TP53 cervix,NS,carcinoma,adenocarcinoma c.625C>T p.R209W 17:7674221-7674221 12
48 COSM143943797 TP53 cervix,NS,carcinoma,adenocarcinoma c.266G>A p.R89Q 17:7674220-7674220 12
49 COSM144052515 TP53 cervix,NS,carcinoma,adenocarcinoma c.200G>T p.G67V 17:7674286-7674286 12
50 COSM122271559 TP53 cervix,NS,carcinoma,adenocarcinoma c.347G>A p.R116Q 17:7674220-7674220 12

Expression for Glassy Cell Carcinoma of the Cervix

Search GEO for disease gene expression data for Glassy Cell Carcinoma of the Cervix.

Pathways for Glassy Cell Carcinoma of the Cervix

Pathways related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.8 PGR ESR1 ERBB2
2
Show member pathways
11.73 ESR1 ERBB2
3 11.68 ESR1 ERBB2
4
Show member pathways
11.57 PGR ESR1
5
Show member pathways
11.23 ESR1 ERBB2
6
Show member pathways
11.11 PGR ESR1
7
Show member pathways
10.83 PGR ESR1 ERBB2

GO Terms for Glassy Cell Carcinoma of the Cervix

Biological processes related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.26 ESR1 ERBB2
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.16 PGR ESR1
3 steroid hormone mediated signaling pathway GO:0043401 8.96 PGR ESR1
4 intracellular steroid hormone receptor signaling pathway GO:0030518 8.62 PGR ESR1

Molecular functions related to Glassy Cell Carcinoma of the Cervix according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase binding GO:0051117 9.26 PGR ESR1
2 nuclear receptor activity GO:0004879 9.16 PGR ESR1
3 steroid binding GO:0005496 8.96 PGR ESR1
4 steroid hormone receptor activity GO:0003707 8.62 PGR ESR1

Sources for Glassy Cell Carcinoma of the Cervix

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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