Glaucoma 1, Open Angle, M disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Glaucoma 1, Open Angle, M

MalaCards integrated aliases for Glaucoma 1, Open Angle, M:

Name: Glaucoma 1, Open Angle, M ⁵⁷ ²⁹ ¹³ ⁷⁰

Glc1m ⁵⁷

Characteristics:

OMIM®:

⁵⁷ (Updated 05-Apr-2021)

Inheritance:
autosomal dominant

Miscellaneous:
age of onset/diagnosis 12-35 years

HPO:

³¹

glaucoma 1, open angle, m:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Eye diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM® ⁵⁷ 610535

MedGen ⁴¹ C1864653

SNOMED-CT via HPO ⁶⁸ 1151008 263681008 267628004 more

UMLS ⁷⁰ C1864653

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Summaries for Glaucoma 1, Open Angle, M

MalaCards based summary : Glaucoma 1, Open Angle, M, also known as glc1m, is related to glaucoma, primary open angle and intraocular pressure quantitative trait locus. An important gene associated with Glaucoma 1, Open Angle, M is GLC1M (Glaucoma 1, Open Angle, M (Juvenile-Onset)). Related phenotypes are constriction of peripheral visual field and open angle glaucoma

More information from OMIM: 610535

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Related Diseases for Glaucoma 1, Open Angle, M

Diseases in the Open-Angle Glaucoma family:

Glaucoma 1, Open Angle, a	Glaucoma, Primary Open Angle
Glaucoma 1, Open Angle, P	Glaucoma 1, Primary Open Angle, C
Glaucoma 1, Open Angle, D	Glaucoma 1, Open Angle, F
Glaucoma 1, Open Angle, B	Glaucoma 1, Open Angle, J
Glaucoma 1, Open Angle, K	Glaucoma 1, Open Angle, I
Glaucoma 1, Open Angle, G	Glaucoma 1, Open Angle, M
Glaucoma 1, Open Angle, N	Glaucoma 1, Open Angle, H
Glaucoma 1, Open Angle, O

Diseases related to Glaucoma 1, Open Angle, M via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	glaucoma, primary open angle	9.9
2	intraocular pressure quantitative trait locus	9.9
3	open-angle glaucoma	9.9

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Symptoms & Phenotypes for Glaucoma 1, Open Angle, M

Human phenotypes related to Glaucoma 1, Open Angle, M:

³¹

#	Description	HPO Frequency	HPO Source Accession
1	constriction of peripheral visual field ³¹		HP:0001133
2	open angle glaucoma ³¹		HP:0012108

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 05-Apr-2021)

Head And Neck Eyes:
visual field loss
anterior chamber angle open with grade iii-iv gonioscopy
bilateral intraocular pressures greater than or equal to 22 mmhg
vertical cup-to-disc ratio greater than or equal to 0.7
disc hemorrhage
more

Clinical features from OMIM®:

610535 (Updated 05-Apr-2021)

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Drugs & Therapeutics for Glaucoma 1, Open Angle, M

Search Clinical Trials , NIH Clinical Center for Glaucoma 1, Open Angle, M

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Genetic Tests for Glaucoma 1, Open Angle, M

Genetic tests related to Glaucoma 1, Open Angle, M:

#	Genetic test	Affiliating Genes
1	Glaucoma 1, Open Angle, M ²⁹

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Anatomical Context for Glaucoma 1, Open Angle, M

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Publications for Glaucoma 1, Open Angle, M

Articles related to Glaucoma 1, Open Angle, M:

#	Title	Authors	PMID	Year
1	Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene. ⁵⁷ ⁶¹	Fan BJ...Pang CP	17563728	2007
2	A genome-wide scan maps a novel juvenile-onset primary open angle glaucoma locus to chromosome 5q. ⁵⁷	Pang CP...Ritch R	16518310	2006
3	Absence of myocilin and optineurin mutations in a large Philippine family with juvenile onset primary open angle glaucoma. ⁵⁷	Wang DY...Pang CP	15547491	2004
4	Evaluation of SPARC as a candidate gene of juvenile-onset primary open-angle glaucoma by mutation and copy number analyses. ⁶¹	Chen LJ...Pang CP	21042566	2010

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Genes for Glaucoma 1, Open Angle, M

Genes related to Glaucoma 1, Open Angle, M (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	GLC1M	Glaucoma 1, Open Angle, M (Juvenile-Onset)	Genetic Locus	58.7	Genetic linkage ⁵⁷ GeneCards inferred via : Gene name (show sections)

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Variations for Glaucoma 1, Open Angle, M

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Expression for Glaucoma 1, Open Angle, M

Search GEO for disease gene expression data for Glaucoma 1, Open Angle, M.

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Pathways for Glaucoma 1, Open Angle, M

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GO Terms for Glaucoma 1, Open Angle, M

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Sources for Glaucoma 1, Open Angle, M

¹ BioSystems

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²⁸ GO

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⁴⁰ MalaCards

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⁵² NIH Clinical Center

⁵³ NINDS

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⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

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⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

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⁶⁴ R&D Systems

⁶⁵ Reactome

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⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Glaucoma 1, Open Angle, M (GLC1M)

Aliases & Classifications for Glaucoma 1, Open Angle, M

MalaCards integrated aliases for Glaucoma 1, Open Angle, M:

Characteristics:

OMIM®:

HPO:

Classifications:

External Ids:

Summaries for Glaucoma 1, Open Angle, M

Related Diseases for Glaucoma 1, Open Angle, M

Diseases in the Open-Angle Glaucoma family:

Diseases related to Glaucoma 1, Open Angle, M via text searches within MalaCards or GeneCards Suite gene sharing:

Symptoms & Phenotypes for Glaucoma 1, Open Angle, M

Human phenotypes related to Glaucoma 1, Open Angle, M:

Symptoms via clinical synopsis from OMIM®:

Clinical features from OMIM®:

Drugs & Therapeutics for Glaucoma 1, Open Angle, M

Genetic Tests for Glaucoma 1, Open Angle, M

Genetic tests related to Glaucoma 1, Open Angle, M:

Anatomical Context for Glaucoma 1, Open Angle, M

Publications for Glaucoma 1, Open Angle, M

Articles related to Glaucoma 1, Open Angle, M:

Genes for Glaucoma 1, Open Angle, M

Genes related to Glaucoma 1, Open Angle, M (1 elite genes):

Variations for Glaucoma 1, Open Angle, M

Expression for Glaucoma 1, Open Angle, M

Pathways for Glaucoma 1, Open Angle, M

GO Terms for Glaucoma 1, Open Angle, M

Sources for Glaucoma 1, Open Angle, M