MCID: GLC084
MIFTS: 39

Glaucoma, Normal Tension

Categories: Genetic diseases

Aliases & Classifications for Glaucoma, Normal Tension

MalaCards integrated aliases for Glaucoma, Normal Tension:

Name: Glaucoma, Normal Tension 57
Glaucoma, Normal Tension, Susceptibility to 57 29 13 6 40
Npg 57 75 3
Ntg 57 75
Glaucoma, Normal Pressure, Susceptibility to 57
Glaucoma, Normal Pressure ; Npg 57
Glaucoma, Normal Pressure 75
Normal Tension Glaucoma 75
Low Tension Glaucoma 73

Classifications:



External Ids:

OMIM 57 606657
MedGen 42 C1847730
MeSH 44 D005901

Summaries for Glaucoma, Normal Tension

CDC : 3 The NIOSH Pocket Guide to Chemical Hazards (NPG) informs workers, employers, and occupational health professionals about workplace chemicals and their hazards. The NPG gives general industrial hygiene information for hundreds of chemicals/classes. The NPG clearly presents key data for chemicals or substance groupings (such as cyanides, fluorides, manganese compounds) that are found in workplaces. The guide offers key facts, but does not give all relevant data. The NPG helps users recognize and control workplace chemical hazards.

MalaCards based summary : Glaucoma, Normal Tension, also known as glaucoma, normal tension, susceptibility to, is related to glaucoma, primary open angle and open-angle glaucoma. An important gene associated with Glaucoma, Normal Tension is OPA1 (OPA1, Mitochondrial Dynamin Like GTPase), and among its related pathways/superpathways are CD28 co-stimulation and EGF/EGFR Signaling Pathway. The drugs Timolol and Travoprost have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related phenotype is homeostasis/metabolism.

UniProtKB/Swiss-Prot : 75 Glaucoma, normal pressure: A primary glaucoma characterized by intraocular pression consistently within the statistically normal population range.

Description from OMIM: 606657

Related Diseases for Glaucoma, Normal Tension

Diseases related to Glaucoma, Normal Tension via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 glaucoma, primary open angle 29.6 LOXL1 OPTN
2 open-angle glaucoma 29.2 LOXL1 OPTN
3 low tension glaucoma 11.3
4 ocular hypertension 10.1
5 goiter 10.1
6 nontoxic goiter 10.1
7 optic nerve disease 9.9 OPA1 OPTN
8 intraocular pressure quantitative trait locus 9.8 LOXL1 OPTN
9 phacogenic glaucoma 9.8 LOXL1 OPTN
10 exfoliation syndrome 9.8
11 cataract 9.8
12 iris disease 9.8 LOXL1 OPTN
13 vernal conjunctivitis 9.7 LOXL1 OPTN
14 3-methylglutaconic aciduria, type iii 9.7 OPA1 OPTN

Graphical network of the top 20 diseases related to Glaucoma, Normal Tension:



Diseases related to Glaucoma, Normal Tension

Symptoms & Phenotypes for Glaucoma, Normal Tension

Clinical features from OMIM:

606657

MGI Mouse Phenotypes related to Glaucoma, Normal Tension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 LOXL1 OPA1 OPTN VAV2 VAV3

Drugs & Therapeutics for Glaucoma, Normal Tension

Drugs for Glaucoma, Normal Tension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Timolol Approved Phase 4,Phase 2,Not Applicable 26839-75-8 33624 5478
2
Travoprost Approved Phase 4 157283-68-6 5282226
3
Brinzolamide Approved Phase 4 138890-62-7 68844
4
Dipivefrin Approved Phase 4,Not Applicable 52365-63-6 3105
5
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
6
Maleic acid Experimental Phase 4 110-16-7 444266
7 Adrenergic Agents Phase 4,Phase 2,Not Applicable
8 Adrenergic Agonists Phase 4,Phase 2,Not Applicable
9 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2,Not Applicable
10 Adrenergic alpha-Agonists Phase 4,Phase 2,Not Applicable
11 Adrenergic Antagonists Phase 4,Phase 2,Not Applicable
12 Adrenergic beta-Antagonists Phase 4,Phase 2,Not Applicable
13 Anti-Arrhythmia Agents Phase 4,Phase 2,Not Applicable
14 Antihypertensive Agents Phase 4,Phase 2,Not Applicable
15 Brimonidine Tartrate Phase 4,Phase 2,Not Applicable 70359-46-5
16 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
17 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
18 Ophthalmic Solutions Phase 4,Phase 2,Not Applicable
19 Pharmaceutical Solutions Phase 4,Phase 2,Not Applicable
20 Tetrahydrozoline Phase 4,Not Applicable
21 Carbonic Anhydrase Inhibitors Phase 4,Phase 2,Not Applicable
22 Anti-Infective Agents Phase 4
23 Anti-Infective Agents, Local Phase 4
24 Benzalkonium Compounds Phase 4
25
Dorzolamide Approved Phase 2,Not Applicable 120279-96-1 3154 5284549
26
Phenytoin Approved, Vet_approved 57-41-0 1775
27
Latanoprost Approved, Investigational Not Applicable 130209-82-4 5282380 5311221
28
Ephedrine Approved Not Applicable 299-42-3 9294
29
Pseudoephedrine Approved Not Applicable 90-82-4 7028
30 Anticonvulsants
31 Convulsants
32 Diuretics, Potassium Sparing
33 Sodium Channel Blockers
34 Autonomic Agents Not Applicable
35 Nasal Decongestants Not Applicable
36 Peripheral Nervous System Agents Not Applicable
37 Respiratory System Agents Not Applicable
38 Vasoconstrictor Agents Not Applicable
39 Antioxidants
40
Bilirubin 635-65-4 5280352
41 Protective Agents
42 Anesthetics ,Not Applicable
43 Central Nervous System Depressants
44 Proxymetacaine Not Applicable

Interventional clinical trials:

(show top 50) (show all 59)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Combigan and 0.5% Timoptic in Normal Tension Glaucoma Unknown status NCT01446497 Phase 4 Brimonidine/Timolol mixed combination;Timolol
2 Investigation of Intraocular Pressure (IOP) Reduction Efficacy of Travoprost Ophthalmic Solution in Patients With Normal Tension Glaucoma Completed NCT01995136 Phase 4 Travoprost Ophthalmic Solution 0.004%
3 Additive Effect of Twice-daily Brinzolamide 1% / Brimonidine 0.2%Combination as an Adjunctive Therapy to Travoprost in Patients With Normal Tension Glaucoma Completed NCT03150160 Phase 4 brinzolamide 1% / brimonidine 0.2%;Placebo
4 Effect of Selective Laser Trabeculoplasty Versus Travoprost on Circardian Intraocular Pressure Completed NCT02105311 Phase 4 Travoprost
5 Efficacy and Safety of COMBIGAN® in Korean Patients With Primary Open Angle Glaucoma (POAG) and Normal Tension Glaucoma (NTG) Active, not recruiting NCT02863705 Phase 4 brimonidine tartrate/timolol malate Ophthalmic Solution;bimatoprost ophthalmic solution 0.01%
6 Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study Active, not recruiting NCT03323164 Phase 4 Timolol Maleate;Brimonidine Tartrate
7 Evaluation of PHP-201 Ophthalmic Solution in Patients With Normal Tension Glaucoma Completed NCT03106532 Phase 2 PHP-201 0.25% ophthalmic solution;PHP-201 0.5% ophthalmic solution;Placebo ophthalmic solution
8 COSOPT (Timolol/Dorzolamide Combination) Normal Tension Glaucoma Study (MK0507A-161)(COMPLETED) Completed NCT00832377 Phase 2 timolol/dorzolamide combination
9 Study of Medical Treatment of Low-Pressure (Normal Tension) Glaucoma Completed NCT00317577 Phase 2 brimonidine, timolol
10 Assessment of Optic Nerve Radiation in Patients With Glaucoma and Ocular Hypertension by 7 Tesla Diffusion Tensor Imaging Recruiting NCT01864317 Phase 2
11 Psychopathology of Normal-tension Glaucoma in Hong Kong Chinese Out-patient Unknown status NCT00324181
12 Analysis of Clinical Profiles of Chinese Patients With Normal Tension Glaucoma Unknown status NCT00321386
13 Correlation of Orbital Cerebrospinal Fluid Pressure and Retinal Venous Outflow in Primary Open-angle Glaucoma Unknown status NCT01795014
14 Study on the Oxygen Saturation in Pulsating and Non-pulsating Central Retinal Veins Unknown status NCT01794442
15 Normal Tension and Chronic Open Angle Glaucoma and Cerebrospinal Fluid Composition Unknown status NCT00306657 Not Applicable
16 Protective Effect of Phenytoin on Glaucoma Unknown status NCT00739154
17 Blood Flow of Ophthalmic Artery and Glaucoma Unknown status NCT02656979 Not Applicable Latanoprost
18 Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS) Unknown status NCT00874913 Not Applicable
19 Prospective Study Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348672
20 Pressure Difference Between Brain and Eye: a Possible Cause to Normal Tension Glaucoma. Completed NCT02776449
21 Intraocular Pressure and Ocular Perfusion Pressure of Cosopt in Normal Tension Glaucoma Completed NCT01175902 Not Applicable dorzolamide/timolol;latanoprost
22 Serum Bilirubin Levels in Normal-tension Glaucoma Completed NCT03387306
23 Systemic Glutathione Level in Normal Tension Glaucoma Completed NCT00570362
24 Autonomic Nervous System Activity and Normal Tension Glaucoma Completed NCT01192061
25 A New View of Normal Tension Glaucoma: Autoregulation and Systemic Blood Pressure Completed NCT00706056
26 Magnetic Resonance Imaging of Patients With Normal Tension Glaucoma Completed NCT00175786
27 Observational Study of the Long-term Effect of Latanoprost in Normal Tension Glaucoma Completed NCT01209624
28 Effect of Alphagan on Retinal Blood Flow Autoregulation and Motion Detection in Patients With Normal Pressure Glaucoma Completed NCT01105065 Not Applicable brimonidine 0.15%
29 Waveform Analysis of the Doppler Curve of Ophthalmic Arteries in Glaucoma Patients Completed NCT01487655
30 Spectral Domain Optical Coherence Tomography Analysis for Glaucoma Completed NCT01612416 Not Applicable
31 Validation of Retinal Oximetry in Glaucoma Patients: a Structural and Functional Correlation Completed NCT01391247
32 Pilot Study on Ambulatory Intraocular Pressure and Blood Pressure Monitoring in Glaucoma Completed NCT01912599 Not Applicable
33 Ocular Blood Flow in Glaucoma Patients - the Leuven Eye Study Completed NCT01840202
34 Differences in Nerve Fiber Layer Between Patients With Normal- and High-Pressure-Glaucoma Completed NCT01488032
35 Alcon Ex-PRESS™ Glaucoma Filtration Device in Japanese Patients Completed NCT02246777 Not Applicable
36 Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments. Completed NCT00347191
37 IOP Lowering Effects of Topical Anesthetics Used Frequently in the Ophthalmology Clinic Completed NCT01254149
38 Study on Ocular Blood Flow and the Orbital Cerebrospinal Fluid Pressure in Glaucoma Completed NCT01802463
39 Macular Retinoschisis and Detachment Associated With Glaucomatous Optic Neuropathy Completed NCT01862627
40 Relationship Between 24-hour IOP Pattern and the 24-hour Blood Pressure Pattern in Patients With POAG Completed NCT01769521 Not Applicable
41 Evaluation of Corneal Temperature by Infrared Thermography in Glaucoma Patients Completed NCT02674074 Not Applicable
42 Analysis of Visual Pathways in Glaucoma Patients Using a 3tesla-MRI Completed NCT01621841
43 Correlation of Optic Disk Morphology and Ocular Perfusion Parameters in Patients With Primary Open Angle Glaucoma Completed NCT00803504
44 Clinical and Molecular Studies in Families With Glaucoma and Related Diseases Completed NCT00272363
45 Effects of Latanoprost on Choroidal Blood Flow Regulation in Human Subjects Completed NCT00712400 Not Applicable Latanoprost 0.005%, Xalatan®;Placebo
46 Study on the Impact of Ocular Anesthetic Procedures in Ocular Blood Flow Completed NCT01840215
47 Intraocular Pressure and Hemodialysis Midwestern Brazil Completed NCT02405884 Not Applicable
48 Does the Optic Disc Grading Done Visually by Your Doctor Agree With Optic Nerve Testing Which is Done by Machines? Completed NCT00430287
49 Will Listening to Music Make it Easier to Take a Visual Field Test? Completed NCT01027039
50 mRNA Expression in Lymphocytes of Glaucoma Patients Completed NCT00327509

Search NIH Clinical Center for Glaucoma, Normal Tension

Genetic Tests for Glaucoma, Normal Tension

Genetic tests related to Glaucoma, Normal Tension:

# Genetic test Affiliating Genes
1 Glaucoma, Normal Tension, Susceptibility to 29 OPA1 OPTN

Anatomical Context for Glaucoma, Normal Tension

MalaCards organs/tissues related to Glaucoma, Normal Tension:

41
Eye, Testes, Brain

Publications for Glaucoma, Normal Tension

Articles related to Glaucoma, Normal Tension:

# Title Authors Year
1
Molecular genetic analysis of primary open-angle glaucoma, normal tension glaucoma, and developmental glaucoma for the VAV2 and VAV3 gene variants in Japanese subjects. ( 23402756 )
2013
2
LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract. ( 18958304 )
2008
3
Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study. ( 18719086 )
2008
4
A comparison of optic disc topographic parameters in patients with primary open angle glaucoma, normal tension glaucoma, and ocular hypertension. ( 12819980 )
2003
5
Evaluation of central corneal thickness in patients affected by ocular hypertension, primary open-angle glaucoma, normal tension glaucoma. ( 12390138 )
2002
6
Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension. ( 12185121 )
2002
7
Fluctuations of intraocular pressure during the day in open-angle glaucoma, normal-tension glaucoma and normal subjects. ( 9486551 )
1998

Variations for Glaucoma, Normal Tension

Expression for Glaucoma, Normal Tension

Search GEO for disease gene expression data for Glaucoma, Normal Tension.

Pathways for Glaucoma, Normal Tension

GO Terms for Glaucoma, Normal Tension

Biological processes related to Glaucoma, Normal Tension according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of small GTPase mediated signal transduction GO:0051056 9.51 VAV2 VAV3
2 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 9.49 VAV2 VAV3
3 platelet activation GO:0030168 9.48 VAV2 VAV3
4 small GTPase mediated signal transduction GO:0007264 9.46 VAV2 VAV3
5 regulation of GTPase activity GO:0043087 9.43 VAV2 VAV3
6 regulation of Rho protein signal transduction GO:0035023 9.4 VAV2 VAV3
7 ephrin receptor signaling pathway GO:0048013 9.37 VAV2 VAV3
8 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.32 VAV2 VAV3
9 lamellipodium assembly GO:0030032 9.26 VAV2 VAV3
10 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.16 VAV2 VAV3
11 cell projection assembly GO:0030031 8.96 VAV2 VAV3
12 regulation of cell size GO:0008361 8.62 VAV2 VAV3

Molecular functions related to Glaucoma, Normal Tension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 guanyl-nucleotide exchange factor activity GO:0005085 9.16 VAV2 VAV3
2 Rho guanyl-nucleotide exchange factor activity GO:0005089 8.96 VAV2 VAV3
3 epidermal growth factor receptor binding GO:0005154 8.62 VAV2 VAV3

Sources for Glaucoma, Normal Tension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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