NPG
MCID: GLC084
MIFTS: 42

Glaucoma, Normal Tension (NPG)

Categories: Genetic diseases, Neuronal diseases

Aliases & Classifications for Glaucoma, Normal Tension

MalaCards integrated aliases for Glaucoma, Normal Tension:

Name: Glaucoma, Normal Tension 58
Glaucoma, Normal Tension, Susceptibility to 58 30 13 6 41
Npg 58 76 3
Ntg 58 76
Glaucoma, Normal Pressure, Susceptibility to 58
Glaucoma, Normal Pressure ; Npg 58
Glaucoma, Normal Pressure 76
Normal Tension Glaucoma 76
Low Tension Glaucoma 74

Classifications:



External Ids:

OMIM 58 606657
MeSH 45 D005901
MedGen 43 C1847730
UMLS 74 C0152136

Summaries for Glaucoma, Normal Tension

CDC : 3 The NIOSH Pocket Guide to Chemical Hazards (NPG) informs workers, employers, and occupational health professionals about workplace chemicals and their hazards. The NPG gives general industrial hygiene information for hundreds of chemicals/classes. The NPG clearly presents key data for chemicals or substance groupings (such as cyanides, fluorides, manganese compounds) that are found in workplaces. The guide offers key facts, but does not give all relevant data. The NPG helps users recognize and control workplace chemical hazards.

MalaCards based summary : Glaucoma, Normal Tension, also known as glaucoma, normal tension, susceptibility to, is related to optic nerve disease and glaucoma, primary open angle. An important gene associated with Glaucoma, Normal Tension is OPA1 (OPA1 Mitochondrial Dynamin Like GTPase), and among its related pathways/superpathways are CD28 co-stimulation and EGF/EGFR Signaling Pathway. The drugs Timolol and Travoprost have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related phenotype is homeostasis/metabolism.

UniProtKB/Swiss-Prot : 76 Glaucoma, normal pressure: A primary glaucoma characterized by intraocular pression consistently within the statistically normal population range.

Wikipedia : 77 Normal tension glaucoma (NTG) is an eye disease, a neuropathy of the optic nerve, that shows all the... more...

Description from OMIM: 606657

Related Diseases for Glaucoma, Normal Tension

Diseases related to Glaucoma, Normal Tension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 optic nerve disease 30.4 OPA1 OPTN
2 glaucoma, primary open angle 30.1 LOXL1 OPTN
3 open-angle glaucoma 29.9 LOXL1 OPTN
4 low tension glaucoma 11.8
5 glaucoma 1, open angle, p 11.2
6 intraocular pressure quantitative trait locus 11.2
7 neuropathy 10.4
8 sleep apnea 10.4
9 alzheimer disease 10.3
10 apnea, obstructive sleep 10.3
11 myopia 10.3
12 retinal vein occlusion 10.2
13 scotoma 10.2
14 ocular hypertension 10.2
15 migraine with or without aura 1 10.2
16 goiter 10.2
17 nontoxic goiter 10.2
18 3-methylglutaconic aciduria, type iii 10.1
19 nonarteritic anterior ischemic optic neuropathy 10.1
20 ischemic optic neuropathy 10.1
21 retinal degeneration 10.1
22 retinoschisis 1, x-linked, juvenile 10.1
23 kearns-sayre syndrome 10.1
24 keratoconus 10.1
25 chronic closed-angle glaucoma 10.1
26 dengue shock syndrome 10.0
27 pain agnosia 10.0
28 colitis 10.0
29 allergic encephalomyelitis 10.0
30 systemic lupus erythematosus 9.9
31 optic atrophy 1 9.9
32 optic nerve hypoplasia, bilateral 9.9
33 hydrocephalus, normal-pressure 9.9
34 helicobacter pylori infection 9.9
35 yemenite deaf-blind hypopigmentation syndrome 9.9
36 glaucoma 1, open angle, f 9.9
37 occult macular dystrophy 9.9
38 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
39 hydrocephalus 9.9
40 atrial fibrillation 9.9
41 sensorineural hearing loss 9.9
42 primary angle-closure glaucoma 9.9
43 central retinal vein occlusion 9.9
44 thrombophilia 9.9
45 retinal vascular disease 9.9
46 cerebrovascular disease 9.9
47 leber hereditary optic neuropathy 9.9
48 collagen disease 9.9
49 lupus erythematosus 9.9
50 anterior segment dysgenesis 9.9

Graphical network of the top 20 diseases related to Glaucoma, Normal Tension:



Diseases related to Glaucoma, Normal Tension

Symptoms & Phenotypes for Glaucoma, Normal Tension

Clinical features from OMIM:

606657

MGI Mouse Phenotypes related to Glaucoma, Normal Tension:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 LOXL1 OPA1 OPTN VAV2 VAV3

Drugs & Therapeutics for Glaucoma, Normal Tension

Drugs for Glaucoma, Normal Tension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Timolol Approved Phase 4,Phase 2,Not Applicable 26839-75-8 5478 33624
2
Travoprost Approved Phase 4 157283-68-6 5282226
3
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
4
Brinzolamide Approved Phase 4 138890-62-7 68844
5
Dipivefrin Approved Phase 4,Not Applicable 52365-63-6 3105
6
Maleic acid Experimental, Investigational Phase 4 110-17-8, 110-16-7 444972
7 Adrenergic Antagonists Phase 4,Phase 2,Not Applicable
8 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
9 Brimonidine Tartrate Phase 4,Phase 2,Not Applicable 70359-46-5
10 Adrenergic beta-Antagonists Phase 4,Phase 2,Not Applicable
11 Adrenergic Agonists Phase 4,Phase 2,Not Applicable
12 Anti-Arrhythmia Agents Phase 4,Phase 2,Not Applicable
13 Ophthalmic Solutions Phase 4,Phase 2,Not Applicable
14 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2,Not Applicable
15 Neurotransmitter Agents Phase 4,Phase 2,Not Applicable
16 Adrenergic alpha-Agonists Phase 4,Phase 2,Not Applicable
17 Adrenergic Agents Phase 4,Phase 2,Not Applicable
18 Antihypertensive Agents Phase 4,Phase 2,Not Applicable
19 Pharmaceutical Solutions Phase 4,Phase 2,Not Applicable
20 Carbonic Anhydrase Inhibitors Phase 4,Phase 2,Not Applicable
21 Anti-Infective Agents, Local Phase 4
22 Benzalkonium Compounds Phase 4
23 Anti-Infective Agents Phase 4
24
Dorzolamide Approved Phase 2,Not Applicable 120279-96-1 5284549 3154
25
Phenytoin Approved, Vet_approved 57-41-0 1775
26
Latanoprost Approved, Investigational Not Applicable 130209-82-4 5311221 5282380
27
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
28
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
29 Diuretics, Potassium Sparing
30 Anticonvulsants
31 Sodium Channel Blockers
32 Convulsants
33 Antioxidants
34 Protective Agents
35
Bilirubin 635-65-4, 69853-43-6 21252250 5280352
36 Ginkgo Not Applicable
37 Central Nervous System Depressants
38 Anesthetics ,Not Applicable
39 Proxymetacaine Not Applicable
40 Autonomic Agents
41 BB 1101
42 Hormones
43 Peripheral Nervous System Agents
44 Anti-Inflammatory Agents
45 glucocorticoids
46 Hormones, Hormone Substitutes, and Hormone Antagonists
47 Gastrointestinal Agents
48 Hormone Antagonists
49 Antineoplastic Agents, Hormonal
50 Antiemetics

Interventional clinical trials:

(show top 50) (show all 63)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Combigan and 0.5% Timoptic in Normal Tension Glaucoma Unknown status NCT01446497 Phase 4 Brimonidine/Timolol mixed combination;Timolol
2 Investigation of Intraocular Pressure (IOP) Reduction Efficacy of Travoprost Ophthalmic Solution in Patients With Normal Tension Glaucoma Completed NCT01995136 Phase 4 Travoprost Ophthalmic Solution 0.004%
3 Efficacy and Safety of COMBIGAN® in Korean Patients With Primary Open Angle Glaucoma (POAG) and Normal Tension Glaucoma (NTG) Completed NCT02863705 Phase 4 brimonidine tartrate/timolol malate Ophthalmic Solution;bimatoprost ophthalmic solution 0.01%
4 Additive Effect of Twice-daily Brinzolamide 1%/Brimonidine 0.2%Combination as an Adjunctive Therapy to Travoprost in Patients With Normal Tension Glaucoma Completed NCT03150160 Phase 4 brinzolamide 1%/brimonidine 0.2% fixed combination;Placebo;travoprost 0.004% ophthalmic solution
5 Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study Active, not recruiting NCT03323164 Phase 4 Timolol Maleate;Brimonidine Tartrate
6 Effect of Selective Laser Trabeculoplasty Versus Travoprost on Circardian Intraocular Pressure Completed NCT02105311 Phase 4 Travoprost
7 Evaluation of PHP-201 Ophthalmic Solution in Patients With Normal Tension Glaucoma Completed NCT03106532 Phase 2 PHP-201 0.25% ophthalmic solution;PHP-201 0.5% ophthalmic solution;Placebo ophthalmic solution
8 COSOPT (Timolol/Dorzolamide Combination) Normal Tension Glaucoma Study (MK0507A-161)(COMPLETED) Completed NCT00832377 Phase 2 timolol/dorzolamide combination
9 Assessment of Optic Nerve Radiation in Patients With Glaucoma and Ocular Hypertension by 7 Tesla Diffusion Tensor Imaging Recruiting NCT01864317 Phase 2
10 Study of Medical Treatment of Low-Pressure (Normal Tension) Glaucoma Completed NCT00317577 Phase 2 brimonidine, timolol
11 Psychopathology of Normal-tension Glaucoma in Hong Kong Chinese Out-patient Unknown status NCT00324181
12 Analysis of Clinical Profiles of Chinese Patients With Normal Tension Glaucoma Unknown status NCT00321386
13 Metabolomics in Surgical Ophthalmological Patients Unknown status NCT03098316
14 Correlation of Orbital Cerebrospinal Fluid Pressure and Retinal Venous Outflow in Primary Open-angle Glaucoma Unknown status NCT01795014
15 Study on the Oxygen Saturation in Pulsating and Non-pulsating Central Retinal Veins Unknown status NCT01794442
16 Normal Tension and Chronic Open Angle Glaucoma and Cerebrospinal Fluid Composition Unknown status NCT00306657 Not Applicable
17 Protective Effect of Phenytoin on Glaucoma Unknown status NCT00739154
18 Blood Flow of Ophthalmic Artery and Glaucoma Unknown status NCT02656979 Not Applicable Latanoprost
19 Study of Ocular Blood Flow in Patients With Glaucoma and/or Obstructive Sleep Apnea Syndrome (OSAS) Unknown status NCT00874913 Not Applicable
20 Prospective Study Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348672
21 Pressure Difference Between Brain and Eye: a Possible Cause to Normal Tension Glaucoma. Completed NCT02776449
22 Intraocular Pressure and Ocular Perfusion Pressure of Cosopt in Normal Tension Glaucoma Completed NCT01175902 Not Applicable dorzolamide/timolol;latanoprost
23 Serum Bilirubin Levels in Normal-tension Glaucoma Completed NCT03387306
24 Systemic Glutathione Level in Normal Tension Glaucoma Completed NCT00570362
25 Autonomic Nervous System Activity and Normal Tension Glaucoma Completed NCT01192061
26 A New View of Normal Tension Glaucoma: Autoregulation and Systemic Blood Pressure Completed NCT00706056
27 Magnetic Resonance Imaging of Patients With Normal Tension Glaucoma Completed NCT00175786
28 Observational Study of the Long-term Effect of Latanoprost in Normal Tension Glaucoma Completed NCT01209624
29 Effect of Alphagan on Retinal Blood Flow Autoregulation and Motion Detection in Patients With Normal Pressure Glaucoma Completed NCT01105065 Not Applicable brimonidine 0.15%
30 The Antioxidant Effect of Routine Vascular Therapy for Normal Tension Glaucoma Patients Withdrawn NCT00465348
31 Waveform Analysis of the Doppler Curve of Ophthalmic Arteries in Glaucoma Patients Completed NCT01487655
32 Isometric Exercise in NTG Completed NCT03921372 Not Applicable
33 Spectral Domain Optical Coherence Tomography Analysis for Glaucoma Completed NCT01612416 Not Applicable
34 Evaluation of Blood Flow Regulation With Laser Speckle Flowgraphy Active, not recruiting NCT03391518 Not Applicable
35 Measurement of the Effect of Gingko Biloba Extract on Ocular and Nailfold Blood-flow in NTG Recruiting NCT03761992 Not Applicable
36 Validation of Retinal Oximetry in Glaucoma Patients: a Structural and Functional Correlation Completed NCT01391247
37 LSFG in Patients With Normal Tension Glaucoma Tension Glaucoma Active, not recruiting NCT03318510 Not Applicable
38 Pilot Study on Ambulatory Intraocular Pressure and Blood Pressure Monitoring in Glaucoma Completed NCT01912599 Not Applicable
39 Ocular Blood Flow in Glaucoma Patients - the Leuven Eye Study Completed NCT01840202
40 Differences in Nerve Fiber Layer Between Patients With Normal- and High-Pressure-Glaucoma Completed NCT01488032
41 Alcon® Ex-PRESS® Glaucoma Filtration Device in Japanese Patients Completed NCT02246777 Not Applicable
42 Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments. Completed NCT00347191
43 IOP Lowering Effects of Topical Anesthetics Used Frequently in the Ophthalmology Clinic Completed NCT01254149
44 Study on Ocular Blood Flow and the Orbital Cerebrospinal Fluid Pressure in Glaucoma Completed NCT01802463
45 Investigation of Neurovascular Coupling in Glaucoma Patients and Healthy Subjects Recruiting NCT03870230 Not Applicable
46 Macular Retinoschisis and Detachment Associated With Glaucomatous Optic Neuropathy Completed NCT01862627
47 Relationship Between 24-hour IOP Pattern and the 24-hour Blood Pressure Pattern in Patients With POAG Completed NCT01769521 Not Applicable
48 Advanced Glycation End Products as a Biomarker for Accelerated Ageing Completed NCT02863224
49 Assessing Ocular Hemodynamic Response to Surgical Intervention in Glaucoma Terminated NCT02891317
50 Ocular Blood Flow Assessment in Glaucoma Recruiting NCT02178085 Not Applicable

Search NIH Clinical Center for Glaucoma, Normal Tension

Genetic Tests for Glaucoma, Normal Tension

Genetic tests related to Glaucoma, Normal Tension:

# Genetic test Affiliating Genes
1 Glaucoma, Normal Tension, Susceptibility to 30 OPA1 OPTN

Anatomical Context for Glaucoma, Normal Tension

MalaCards organs/tissues related to Glaucoma, Normal Tension:

42
Eye, Testes, Brain

Publications for Glaucoma, Normal Tension

Articles related to Glaucoma, Normal Tension:

(show all 12)
# Title Authors Year
1
Molecular genetic analysis of primary open-angle glaucoma, normal tension glaucoma, and developmental glaucoma for the VAV2 and VAV3 gene variants in Japanese subjects. ( 23402756 )
2013
2
OPA1 increases the risk of normal but not high tension glaucoma. ( 19581274 )
2010
3
LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract. ( 18958304 )
2008
4
Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study. ( 18719086 )
2008
5
The OPA1 gene polymorphism is associated with normal tension and high tension glaucoma. ( 17188046 )
2007
6
A comparison of optic disc topographic parameters in patients with primary open angle glaucoma, normal tension glaucoma, and ocular hypertension. ( 12819980 )
2003
7
Ocular pulse amplitude in patients with open angle glaucoma, normal tension glaucoma, and ocular hypertension. ( 12185121 )
2002
8
Evaluation of central corneal thickness in patients affected by ocular hypertension, primary open-angle glaucoma, normal tension glaucoma. ( 12390138 )
2002
9
Investigating the association between OPA1 polymorphisms and glaucoma: comparison between normal tension and high tension primary open angle glaucoma. ( 12073024 )
2002
10
Adult-onset primary open-angle glaucoma caused by mutations in optineurin. ( 11834836 )
2002
11
A major marker for normal tension glaucoma: association with polymorphisms in the OPA1 gene. ( 11810296 )
2002
12
Fluctuations of intraocular pressure during the day in open-angle glaucoma, normal-tension glaucoma and normal subjects. ( 9486551 )
1998

Variations for Glaucoma, Normal Tension

ClinVar genetic disease variations for Glaucoma, Normal Tension:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 OPA1 NM_015560.2(OPA1): c.870+4T= single nucleotide variant no interpretation for the single variant rs166850 GRCh37 Chromosome 3, 193355074: 193355074
2 OPA1 NM_015560.2(OPA1): c.870+4T= single nucleotide variant no interpretation for the single variant rs166850 GRCh38 Chromosome 3, 193637285: 193637285
3 OPTN NM_001008211.1(OPTN): c.293T> A (p.Met98Lys) single nucleotide variant Benign rs11258194 GRCh37 Chromosome 10, 13152400: 13152400
4 OPTN NM_001008211.1(OPTN): c.293T> A (p.Met98Lys) single nucleotide variant Benign rs11258194 GRCh38 Chromosome 10, 13110400: 13110400
5 OPA1 NM_015560.2(OPA1): c.870+32T> C single nucleotide variant Benign rs10451941 GRCh37 Chromosome 3, 193355102: 193355102
6 OPA1 NM_015560.2(OPA1): c.870+32T> C single nucleotide variant Benign rs10451941 GRCh38 Chromosome 3, 193637313: 193637313
7 OPA1 NM_015560.2(OPA1): c.599C> T (p.Ser200Phe) single nucleotide variant Uncertain significance rs200243596 GRCh38 Chromosome 3, 193618911: 193618911
8 OPA1 NM_015560.2(OPA1): c.599C> T (p.Ser200Phe) single nucleotide variant Uncertain significance rs200243596 GRCh37 Chromosome 3, 193336700: 193336700

Expression for Glaucoma, Normal Tension

Search GEO for disease gene expression data for Glaucoma, Normal Tension.

Pathways for Glaucoma, Normal Tension

GO Terms for Glaucoma, Normal Tension

Biological processes related to Glaucoma, Normal Tension according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of small GTPase mediated signal transduction GO:0051056 9.52 VAV2 VAV3
2 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 9.51 VAV2 VAV3
3 Fc-epsilon receptor signaling pathway GO:0038095 9.49 VAV2 VAV3
4 small GTPase mediated signal transduction GO:0007264 9.48 VAV2 VAV3
5 platelet activation GO:0030168 9.46 VAV2 VAV3
6 regulation of Rho protein signal transduction GO:0035023 9.43 VAV2 VAV3
7 regulation of GTPase activity GO:0043087 9.4 VAV2 VAV3
8 ephrin receptor signaling pathway GO:0048013 9.37 VAV2 VAV3
9 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.32 VAV2 VAV3
10 lamellipodium assembly GO:0030032 9.26 VAV2 VAV3
11 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.16 VAV2 VAV3
12 regulation of cell size GO:0008361 8.96 VAV2 VAV3
13 cell projection assembly GO:0030031 8.62 VAV2 VAV3

Molecular functions related to Glaucoma, Normal Tension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 guanyl-nucleotide exchange factor activity GO:0005085 9.16 VAV2 VAV3
2 Rho guanyl-nucleotide exchange factor activity GO:0005089 8.96 VAV2 VAV3
3 epidermal growth factor receptor binding GO:0005154 8.62 VAV2 VAV3

Sources for Glaucoma, Normal Tension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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