MCID: GLC001
MIFTS: 31

Glaucomatocyclitic Crisis

Categories: Eye diseases

Aliases & Classifications for Glaucomatocyclitic Crisis

MalaCards integrated aliases for Glaucomatocyclitic Crisis:

Name: Glaucomatocyclitic Crisis 12 15 73
Terrien-Viel Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9378
ICD9CM 35 364.22
SNOMED-CT 68 29538005
UMLS 73 C0152138

Summaries for Glaucomatocyclitic Crisis

MalaCards based summary : Glaucomatocyclitic Crisis, also known as terrien-viel syndrome, is related to iridocyclitis and posner-schlossman syndrome. An important gene associated with Glaucomatocyclitic Crisis is HLA-C (Major Histocompatibility Complex, Class I, C), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Actin Nucleation by ARP-WASP Complex. The drug Antiviral Agents has been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Glaucomatocyclitic Crisis

Diseases related to Glaucomatocyclitic Crisis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 iridocyclitis 30.2 HLA-B MRAP
2 posner-schlossman syndrome 11.7
3 iritis 10.2 HLA-B MRAP
4 panuveitis 10.1 HLA-B MRAP
5 birdshot chorioretinopathy 10.1 HLA-A HLA-C
6 glaucoma, primary open angle 10.1
7 open-angle glaucoma 10.1
8 endotheliitis 10.1
9 phenytoin or carbamazepine toxicity 10.0 HLA-A HLA-B
10 postherpetic neuralgia 10.0 HLA-A HLA-B
11 spondyloarthropathy 1 10.0 HLA-B MRAP
12 atrial tachyarrhythmia with short pr interval 10.0 HLA-A HLA-B
13 sclerosing cholangitis 10.0 HLA-B HLA-C
14 byssinosis 10.0 HLA-A MRAP
15 pars planitis 10.0 HLA-A HLA-B
16 anterior uveitis 10.0 HLA-A HLA-B
17 chronic pyelonephritis 10.0 HLA-A HLA-B
18 nontuberculous mycobacterial lung disease 10.0 HLA-A HLA-B
19 histoplasmosis 10.0 HLA-A HLA-B
20 pure red-cell aplasia 9.9 HLA-A HLA-B
21 adie pupil 9.9
22 optic nerve disease 9.9
23 retinitis 9.9
24 neuropathy 9.9
25 fuchs' heterochromic uveitis 9.9
26 iridocorneal endothelial syndrome 9.9
27 spondylitis 9.9 HLA-B HLA-C
28 separation anxiety disorder 9.9 HLA-A HLA-B
29 aphthous stomatitis 9.9 HLA-A HLA-B
30 vogt-koyanagi-harada disease 9.8 HLA-A HLA-B
31 rubella 9.8 HLA-A HLA-B
32 takayasu arteritis 9.7 HLA-A HLA-B
33 cholangitis, primary sclerosing 9.7 HLA-A HLA-C
34 pityriasis rosea 9.6 HLA-A HLA-B HLA-C
35 human herpesvirus 8 9.6 HLA-A HLA-B HLA-C
36 idiopathic bronchiectasis 9.6 HLA-A HLA-B HLA-C
37 alveolar echinococcosis 9.6 HLA-A HLA-B HLA-C
38 hematopoietic stem cell transplantation 9.6 HLA-A HLA-B HLA-C
39 geographic tongue 9.6 HLA-A HLA-B HLA-C
40 paraneoplastic pemphigus 9.6 HLA-A HLA-B HLA-C
41 severe cutaneous adverse reaction 9.5 HLA-A HLA-B HLA-C
42 graft-versus-host disease 9.5 HLA-A HLA-B HLA-C
43 palindromic rheumatism 9.5 DYNLT1 HLA-A MRAP
44 psoriatic arthritis 9.5 HLA-B HLA-C
45 melanoma, uveal 9.5 HLA-A HLA-B
46 human immunodeficiency virus type 1 9.4 HLA-A HLA-B HLA-C
47 spondyloarthropathy 9.1 HLA-A HLA-B HLA-C MRAP
48 behcet syndrome 8.4 DYNLT1 HLA-A HLA-B HLA-C MRAP

Graphical network of the top 20 diseases related to Glaucomatocyclitic Crisis:



Diseases related to Glaucomatocyclitic Crisis

Symptoms & Phenotypes for Glaucomatocyclitic Crisis

GenomeRNAi Phenotypes related to Glaucomatocyclitic Crisis according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.79 HLA-B HLA-C HLA-A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.79 HLA-C HLA-A HLA-B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.79 HLA-C HLA-A HLA-B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.79 HLA-C
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.79 HLA-C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.79 HLA-C HLA-A HLA-B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.79 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.79 HLA-C HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.79 HLA-B HLA-C HLA-A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.79 HLA-C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.79 HLA-C HLA-A HLA-B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.79 HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.79 HLA-C HLA-A HLA-B
14 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.79 HLA-C HLA-A HLA-B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.79 HLA-C

Drugs & Therapeutics for Glaucomatocyclitic Crisis

Drugs for Glaucomatocyclitic Crisis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antiviral Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Patient Registry of Posner-Schlossman Syndrome Recruiting NCT03233477

Search NIH Clinical Center for Glaucomatocyclitic Crisis

Genetic Tests for Glaucomatocyclitic Crisis

Anatomical Context for Glaucomatocyclitic Crisis

MalaCards organs/tissues related to Glaucomatocyclitic Crisis:

41
Eye, Endothelial

Publications for Glaucomatocyclitic Crisis

Articles related to Glaucomatocyclitic Crisis:

(show all 28)
# Title Authors Year
1
Glaucomatocyclitic crisis and glaucomatous optic neuropathy. ( 29018666 )
2015
2
Trabeculectomy ab interno (trabectome): yet another possibility in the treatment of uncontrolled glaucomatocyclitic crisis under systemic valganciclovir therapy? ( 26139050 )
2015
3
Detection of the progression of retinal nerve fiber layer loss by optical coherence tomography in a patient with glaucomatocyclitic crisis. ( 29018674 )
2015
4
Concurrence of iridocorneal endothelial syndrome in a patient with glaucomatocyclitic crisis. ( 24790889 )
2014
5
Posner-Schlossman glaucomatocyclitic crisis. ( 21958175 )
2011
6
Peripheral vascular endothelial dysfunction in glaucomatocyclitic crisis: a preliminary study. ( 19684007 )
2010
7
Trabeculectomy in the management of glaucomatocyclitic crisis with visual field defect. ( 20482405 )
2010
8
Idiopathic no more: clues to the pathogenesis of Fuchs heterochromic iridocyclitis and glaucomatocyclitic crisis. ( 18435976 )
2008
9
Glaucomatocyclitic crisis in Edo State, Nigeria: report of two cases. ( 18817059 )
2008
10
Posner-Schlossman syndrome (glaucomatocyclitic crisis). ( 17177667 )
2007
11
A case of glaucomatocyclitic crisis in the emergency department. ( 16431228 )
2006
12
Glaucomatocyclitic crisis in a child. ( 10334370 )
1999
13
Glaucomatocyclitic crisis in a child. ( 9683163 )
1998
14
Bilateral glaucomatocyclitic crisis in a patient with Holmes Adie syndrome. ( 10703577 )
1998
15
Reversal of optic disc topography in patients with glaucomatocyclitic crisis after remission of attack. ( 9713778 )
1998
16
Apraclonidine in the management of glaucomatocyclitic crisis. ( 7958055 )
1994
17
Surgical treatment of acute glaucomatocyclitic crisis in a patient with primary open-angle glaucoma. ( 3337205 )
1988
18
HLA-Bw54 and glaucomatocyclitic crisis. ( 4074175 )
1985
19
Protein glaucoma as a possible mechanism in a case of glaucomatocyclitic crisis and periphlebitis. ( 6686277 )
1983
20
Glaucomatocyclitic crisis. ( 6655189 )
1983
21
Glaucomatocyclitic crisis. ( 557968 )
1977
22
Glaucomatocyclitic crisis and primary open-angle glaucoma. ( 4696670 )
1973
23
Glaucomatocyclitic crisis. ( 5062747 )
1972
24
Glaucomatocyclitic crisis (Posner--Schlossman syndrome) case report. ( 4677507 )
1972
25
Developmental factor in the etiopathogenesis of glaucomatocyclitic crisis. ( 4993003 )
1970
26
Glaucomatocyclitic crisis. ( 5418853 )
1970
27
Another case with recurrent glaucomatocyclitic crisis and anomalies in chamber angle, observed during and between hypertensive episodes. Contribution to etiology. ( 5395857 )
1969
28
Observation of glaucomatocyclitic crisis associated with developmental glaucoma: contribution to the etiology. ( 6013046 )
1966

Variations for Glaucomatocyclitic Crisis

Expression for Glaucomatocyclitic Crisis

Search GEO for disease gene expression data for Glaucomatocyclitic Crisis.

Pathways for Glaucomatocyclitic Crisis

Pathways related to Glaucomatocyclitic Crisis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.58 HLA-A HLA-B HLA-C
2
Show member pathways
12.57 HLA-A HLA-B HLA-C
3
Show member pathways
12.48 HLA-A HLA-B HLA-C
4
Show member pathways
12.41 HLA-A HLA-B HLA-C
5
Show member pathways
12.28 HLA-A HLA-B HLA-C
6
Show member pathways
12.23 HLA-A HLA-B HLA-C
7
Show member pathways
12.19 HLA-A HLA-B HLA-C
8
Show member pathways
12.15 HLA-A HLA-B HLA-C
9
Show member pathways
12.1 HLA-A HLA-B HLA-C
10 12.04 HLA-A HLA-B HLA-C
11 12 HLA-A HLA-B HLA-C
12 11.88 HLA-A HLA-B HLA-C
13 11.85 HLA-A HLA-B HLA-C
14 11.7 HLA-A HLA-B HLA-C
15 11.61 HLA-A HLA-B HLA-C
16 11.49 HLA-A HLA-B HLA-C
17 11.26 HLA-A HLA-B HLA-C
18 10.2 HLA-A HLA-B HLA-C

GO Terms for Glaucomatocyclitic Crisis

Cellular components related to Glaucomatocyclitic Crisis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.73 HLA-A HLA-B HLA-C MRAP
2 Golgi apparatus GO:0005794 9.71 DYNLT1 HLA-A HLA-B HLA-C
3 cell surface GO:0009986 9.67 HLA-A HLA-B HLA-C
4 Golgi membrane GO:0000139 9.63 HLA-A HLA-B HLA-C
5 early endosome membrane GO:0031901 9.54 HLA-A HLA-B HLA-C
6 recycling endosome membrane GO:0055038 9.5 HLA-A HLA-B HLA-C
7 secretory granule membrane GO:0030667 9.48 HLA-B HLA-C
8 phagocytic vesicle membrane GO:0030670 9.43 HLA-A HLA-B HLA-C
9 ER to Golgi transport vesicle membrane GO:0012507 9.33 HLA-A HLA-B HLA-C
10 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-A HLA-B HLA-C
11 MHC class I protein complex GO:0042612 8.8 HLA-A HLA-B HLA-C

Biological processes related to Glaucomatocyclitic Crisis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.73 DYNLT1 HLA-A HLA-B HLA-C
2 immune system process GO:0002376 9.69 HLA-A HLA-B HLA-C
3 immune response GO:0006955 9.67 HLA-A HLA-B HLA-C
4 neutrophil degranulation GO:0043312 9.65 DYNLT1 HLA-B HLA-C
5 regulation of immune response GO:0050776 9.63 HLA-A HLA-B HLA-C
6 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.54 HLA-A HLA-B HLA-C
7 interferon-gamma-mediated signaling pathway GO:0060333 9.5 HLA-A HLA-B HLA-C
8 type I interferon signaling pathway GO:0060337 9.43 HLA-A HLA-B HLA-C
9 protection from natural killer cell mediated cytotoxicity GO:0042270 9.4 HLA-A HLA-B
10 antigen processing and presentation GO:0019882 9.33 HLA-A HLA-B HLA-C
11 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.13 HLA-A HLA-B HLA-C
12 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.8 HLA-A HLA-B HLA-C

Molecular functions related to Glaucomatocyclitic Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.13 HLA-A HLA-B HLA-C
2 peptide antigen binding GO:0042605 8.8 HLA-A HLA-B HLA-C

Sources for Glaucomatocyclitic Crisis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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