MCID: GLC001
MIFTS: 40

Glaucomatocyclitic Crisis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Glaucomatocyclitic Crisis

MalaCards integrated aliases for Glaucomatocyclitic Crisis:

Name: Glaucomatocyclitic Crisis 12 53 15 73
Posner-Schlossman Syndrome 12 53
Terrien-Viel Syndrome 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

Disease Ontology 12 DOID:9378
ICD9CM 35 364.22
SNOMED-CT 68 29538005
UMLS 73 C0152138

Summaries for Glaucomatocyclitic Crisis

MalaCards based summary : Glaucomatocyclitic Crisis, also known as posner-schlossman syndrome, is related to uveitis and anterior uveitis. An important gene associated with Glaucomatocyclitic Crisis is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drug Antiviral Agents has been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Glaucomatocyclitic Crisis

Diseases related to Glaucomatocyclitic Crisis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 uveitis 30.8 CXCL10 HLA-B TNF
2 anterior uveitis 30.6 HLA-A HLA-B TNF
3 fuchs' heterochromic uveitis 30.5 CYP11B1 MRAP
4 iridocyclitis 30.3 CYP11B1 HLA-B HLA-DPB1 MRAP
5 cytomegalovirus infection 30.2 CXCL8 HLA-A HLA-B HLA-G TNF
6 nonarteritic anterior ischemic optic neuropathy 10.5
7 ischemic optic neuropathy 10.5
8 herpes simplex 10.5
9 helicobacter pylori infection 10.3
10 phenytoin or carbamazepine toxicity 10.3 HLA-A HLA-B
11 atrial tachyarrhythmia with short pr interval 10.3 HLA-A HLA-B
12 glaucoma, primary open angle 10.2
13 open-angle glaucoma 10.2
14 iritis 10.2 HLA-B MRAP
15 atrophic glossitis 10.2 HLA-A HLA-DQB2
16 human herpesvirus 8 10.2 HLA-A HLA-B HLA-C
17 byssinosis 10.2 HLA-A HLA-DPB1 MRAP
18 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 HLA-A HLA-B HLA-C
19 limbic encephalitis with lgi1 antibodies 10.2 HLA-DQB1 HLA-DRB1
20 idiopathic inflammatory myopathy 10.2 HLA-B HLA-DRB1
21 narcolepsy 2 10.2 HLA-DQB1 HLA-DRB1
22 recurrent hypersomnia 10.2 HLA-DQB1 HLA-DQB2
23 drug reaction with eosinophilia and systemic symptoms 10.2 HLA-B TNF
24 autoimmune polyglandular syndrome type 3 10.2 HLA-DQB1 HLA-DRB1
25 posterior scleritis 10.2 MRAP TNF
26 hypersomnia 10.2 HLA-DQB1 HLA-DRB1
27 pyuria 10.2 CXCL8 MRAP
28 berylliosis 10.2 HLA-DPA1 HLA-DPB1 HLA-DRB1
29 metal allergy 10.1 HLA-DQB1 HLA-DRB1
30 lichen planopilaris 10.1 HLA-DQB1 HLA-DRB1
31 type ii mixed cryoglobulinemia 10.1 HLA-DQB1 HLA-DRB1
32 juvenile ankylosing spondylitis 10.1 MRAP TNF
33 postherpetic neuralgia 10.1 HLA-A HLA-B HLA-DRB1
34 scleral disease 10.1 MRAP TNF
35 pars planitis 10.1 HLA-A HLA-B HLA-DRB1
36 histoplasmosis 10.1 HLA-A HLA-B HLA-DRB1
37 recurrent respiratory papillomatosis 10.1 HLA-DQB1 HLA-DRB1
38 pustulosis of palm and sole 10.1 MRAP TNF
39 pure red-cell aplasia 10.1 HLA-A HLA-B HLA-DRB1
40 maturity-onset diabetes of the young, type 14 10.1 HLA-DQB1 HLA-DQB2
41 narcolepsy 1 10.1 HLA-DQB1 HLA-DRB1
42 whipple disease 10.1 HLA-DQB1 HLA-DRB1 MRAP
43 uveal disease 10.1 HLA-B MRAP TNF
44 neurosyphilis 10.1 CXCL10 CXCL8
45 spondyloarthropathy 1 10.1 HLA-B MRAP TNF
46 exudative glomerulonephritis 10.1 CXCL8 TNF
47 inflammatory bowel disease 3 10.1 HLA-DPA1 HLA-G TNF
48 spondylitis 10.1 HLA-B HLA-C TNF
49 adie pupil 10.1
50 optic nerve disease 10.1

Graphical network of the top 20 diseases related to Glaucomatocyclitic Crisis:



Diseases related to Glaucomatocyclitic Crisis

Symptoms & Phenotypes for Glaucomatocyclitic Crisis

GenomeRNAi Phenotypes related to Glaucomatocyclitic Crisis according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.9 HLA-A HLA-B HLA-C HLA-G
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.9 HLA-A HLA-B HLA-C HLA-G
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.9 HLA-A HLA-B HLA-C HLA-G
4 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.9 HLA-C
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.9 HLA-C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.9 HLA-A HLA-B HLA-C HLA-G
7 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.9 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.9 HLA-A HLA-B HLA-C HLA-G
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.9 HLA-A HLA-B HLA-C HLA-G
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.9 HLA-C
11 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.9 HLA-A HLA-B HLA-C HLA-G
12 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.9 HLA-C
13 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.9 HLA-A HLA-B HLA-C HLA-G
14 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.9 HLA-A HLA-B HLA-C HLA-G
15 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.9 HLA-C

Drugs & Therapeutics for Glaucomatocyclitic Crisis

Drugs for Glaucomatocyclitic Crisis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antiviral Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Patient Registry of Posner-Schlossman Syndrome Recruiting NCT03233477

Search NIH Clinical Center for Glaucomatocyclitic Crisis

Genetic Tests for Glaucomatocyclitic Crisis

Anatomical Context for Glaucomatocyclitic Crisis

MalaCards organs/tissues related to Glaucomatocyclitic Crisis:

41
Eye, Endothelial, Lung, Skin, Bone, Heart, Tongue

Publications for Glaucomatocyclitic Crisis

Articles related to Glaucomatocyclitic Crisis:

(show all 32)
# Title Authors Year
1
The characteristic of intraocular pressure dynamic change in patients with glaucomatocyclitic crisis. ( 30182271 )
2018
2
Digital droplet polymerase chain reaction analysis of common viruses in the aqueous humour of patients with Posner-Schlossman syndrome in Chinese population. ( 30414235 )
2018
3
Glaucomatocyclitic crisis and glaucomatous optic neuropathy. ( 29018666 )
2015
4
Trabeculectomy ab interno (trabectome): yet another possibility in the treatment of uncontrolled glaucomatocyclitic crisis under systemic valganciclovir therapy? ( 26139050 )
2015
5
Detection of the progression of retinal nerve fiber layer loss by optical coherence tomography in a patient with glaucomatocyclitic crisis. ( 29018674 )
2015
6
Concurrence of iridocorneal endothelial syndrome in a patient with glaucomatocyclitic crisis. ( 24790889 )
2014
7
Aqueous cytokine changes associated with Posner-Schlossman syndrome with and without human cytomegalovirus. ( 23028541 )
2012
8
Posner-Schlossman glaucomatocyclitic crisis. ( 21958175 )
2011
9
Peripheral vascular endothelial dysfunction in glaucomatocyclitic crisis: a preliminary study. ( 19684007 )
2010
10
Trabeculectomy in the management of glaucomatocyclitic crisis with visual field defect. ( 20482405 )
2010
11
Idiopathic no more: clues to the pathogenesis of Fuchs heterochromic iridocyclitis and glaucomatocyclitic crisis. ( 18435976 )
2008
12
Glaucomatocyclitic crisis in Edo State, Nigeria: report of two cases. ( 18817059 )
2008
13
Posner-Schlossman syndrome (glaucomatocyclitic crisis). ( 17177667 )
2007
14
A case of glaucomatocyclitic crisis in the emergency department. ( 16431228 )
2006
15
Nonarteritic anterior ischemic optic neuropathy associated with acute glaucoma secondary to Posner-Schlossman syndrome. ( 12523901 )
2003
16
Glaucomatocyclitic crisis in a child. ( 10334370 )
1999
17
Glaucomatocyclitic crisis in a child. ( 9683163 )
1998
18
Bilateral glaucomatocyclitic crisis in a patient with Holmes Adie syndrome. ( 10703577 )
1998
19
Reversal of optic disc topography in patients with glaucomatocyclitic crisis after remission of attack. ( 9713778 )
1998
20
Apraclonidine in the management of glaucomatocyclitic crisis. ( 7958055 )
1994
21
Surgical treatment of acute glaucomatocyclitic crisis in a patient with primary open-angle glaucoma. ( 3337205 )
1988
22
HLA-Bw54 and glaucomatocyclitic crisis. ( 4074175 )
1985
23
Protein glaucoma as a possible mechanism in a case of glaucomatocyclitic crisis and periphlebitis. ( 6686277 )
1983
24
Glaucomatocyclitic crisis. ( 6655189 )
1983
25
Glaucomatocyclitic crisis. ( 557968 )
1977
26
Glaucomatocyclitic crisis and primary open-angle glaucoma. ( 4696670 )
1973
27
Glaucomatocyclitic crisis. ( 5062747 )
1972
28
Glaucomatocyclitic crisis (Posner--Schlossman syndrome) case report. ( 4677507 )
1972
29
Developmental factor in the etiopathogenesis of glaucomatocyclitic crisis. ( 4993003 )
1970
30
Glaucomatocyclitic crisis. ( 5418853 )
1970
31
Another case with recurrent glaucomatocyclitic crisis and anomalies in chamber angle, observed during and between hypertensive episodes. Contribution to etiology. ( 5395857 )
1969
32
Observation of glaucomatocyclitic crisis associated with developmental glaucoma: contribution to the etiology. ( 6013046 )
1966

Variations for Glaucomatocyclitic Crisis

Expression for Glaucomatocyclitic Crisis

Search GEO for disease gene expression data for Glaucomatocyclitic Crisis.

Pathways for Glaucomatocyclitic Crisis

Pathways related to Glaucomatocyclitic Crisis according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 CCL4 CXCL10 CXCL8 DYNLT1 HLA-A HLA-B
2
Show member pathways
13.46 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQB1
3
Show member pathways
13.33 CCL4 CXCL10 CXCL8 HLA-A HLA-B HLA-C
4
Show member pathways
13.07 CCL4 CXCL8 HLA-A HLA-B HLA-C HLA-G
5
Show member pathways
13.01 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DQB1 HLA-DRB1
6
Show member pathways
12.93 HLA-A HLA-B HLA-C HLA-G TNF
7
Show member pathways
12.8 CXCL8 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1
8
Show member pathways
12.66 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1 TNF
9
Show member pathways
12.61 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1 TNF
10
Show member pathways
12.58 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQB1
11
Show member pathways
12.52 HLA-A HLA-B HLA-C HLA-G TNF
12
Show member pathways
12.42 HLA-A HLA-B HLA-C HLA-G
13
Show member pathways
12.38 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
14
Show member pathways
12.38 CXCL10 CXCL8 HLA-A HLA-B HLA-C HLA-DPA1
15 12.36 HLA-A HLA-B HLA-C HLA-G
16 12.32 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQB1
17
Show member pathways
12.29 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DRB1 TNF
18
Show member pathways
12.27 CXCL8 HLA-A HLA-B HLA-C HLA-G TNF
19 12.26 HLA-A HLA-B HLA-C HLA-G
20 12.26 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DRB1 TNF
21
Show member pathways
12.23 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
22 12.18 CXCL8 HLA-A HLA-B HLA-C HLA-G
23 12.15 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQB1
24 12.08 HLA-A HLA-B HLA-C HLA-G
25
Show member pathways
11.97 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
26
Show member pathways
11.97 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
27 11.94 CXCL10 CXCL8 TNF
28 11.94 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
29
Show member pathways
11.93 CCL4 CXCL10 CXCL8
30 11.93 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
31 11.92 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQB1
32
Show member pathways
11.91 CCL4 HLA-A HLA-DRB1
33 11.89 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DRB1 TNF
34 11.89 CXCL8 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DRB1 TNF
35 11.83 CCL4 CXCL8 TNF
36 11.7 HLA-DPA1 HLA-DQB1 HLA-DRB1
37 11.69 CCL4 CXCL10 TNF
38 11.64 CCL4 CXCL8 TNF
39 11.63 CXCL10 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1
40 11.62 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DRB1
41 11.54 CCL4 CXCL10 CXCL8 TNF
42 11.19 CCL4 CXCL10 CXCL8 TNF
43 11.18 HLA-A HLA-B HLA-C HLA-G
44 10.97 CXCL8 TNF

GO Terms for Glaucomatocyclitic Crisis

Cellular components related to Glaucomatocyclitic Crisis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 lysosomal membrane GO:0005765 9.95 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
2 endosome membrane GO:0010008 9.92 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
3 early endosome membrane GO:0031901 9.87 HLA-A HLA-B HLA-C HLA-G
4 trans-Golgi network membrane GO:0032588 9.85 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
5 endocytic vesicle membrane GO:0030666 9.83 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
6 recycling endosome membrane GO:0055038 9.81 HLA-A HLA-B HLA-C HLA-G
7 phagocytic vesicle membrane GO:0030670 9.8 HLA-A HLA-B HLA-C HLA-G
8 transport vesicle membrane GO:0030658 9.8 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
9 clathrin-coated endocytic vesicle membrane GO:0030669 9.65 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
10 MHC class I protein complex GO:0042612 9.62 HLA-A HLA-B HLA-C HLA-G
11 ER to Golgi transport vesicle membrane GO:0012507 9.61 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQB1
12 MHC class II protein complex GO:0042613 9.55 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
13 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.28 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQB1
14 endoplasmic reticulum GO:0005783 10.16 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQB2
15 Golgi apparatus GO:0005794 10.14 DYNLT1 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1
16 endoplasmic reticulum membrane GO:0005789 10.05 HLA-A HLA-DPA1 HLA-DPB1 HLA-DQB2 HLA-DRB1 MRAP
17 cell surface GO:0009986 10.02 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DRB1
18 Golgi membrane GO:0000139 10.02 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQB1

Biological processes related to Glaucomatocyclitic Crisis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.91 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
2 cytokine-mediated signaling pathway GO:0019221 9.9 CCL4 CXCL10 CXCL8 TNF
3 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.89 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
4 regulation of immune response GO:0050776 9.88 HLA-A HLA-B HLA-C HLA-G
5 type I interferon signaling pathway GO:0060337 9.83 HLA-A HLA-B HLA-C HLA-G
6 response to virus GO:0009615 9.78 CCL4 CXCL10 TNF
7 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.78 HLA-A HLA-B HLA-C HLA-G
8 neutrophil chemotaxis GO:0030593 9.77 CCL4 CXCL10 CXCL8
9 chemokine-mediated signaling pathway GO:0070098 9.76 CCL4 CXCL10 CXCL8
10 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.76 HLA-A HLA-B HLA-C HLA-G
11 positive regulation of interferon-gamma production GO:0032729 9.72 HLA-DPA1 HLA-DPB1 TNF
12 positive regulation of T cell mediated cytotoxicity GO:0001916 9.71 HLA-A HLA-B HLA-C HLA-G
13 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.67 HLA-A HLA-B HLA-C HLA-G
14 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.65 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQB2 HLA-DRB1
15 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.62 HLA-A HLA-B HLA-C HLA-G
16 embryonic digestive tract development GO:0048566 9.61 CXCL8 TNF
17 interferon-gamma-mediated signaling pathway GO:0060333 9.61 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQB1
18 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.57 HLA-DQB1 HLA-DRB1
19 protection from natural killer cell mediated cytotoxicity GO:0042270 9.56 HLA-A HLA-B
20 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.54 HLA-DQB1 HLA-DRB1
21 antigen processing and presentation GO:0019882 9.23 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQB1
22 immune system process GO:0002376 10.03 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQB2
23 immune response GO:0006955 10 CCL4 CXCL10 CXCL8 CYP11B1 HLA-A HLA-B

Molecular functions related to Glaucomatocyclitic Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.65 CXCL10 HLA-A HLA-B HLA-C HLA-G
2 cytokine activity GO:0005125 9.62 CCL4 CXCL10 CXCL8 TNF
3 chemokine activity GO:0008009 9.33 CCL4 CXCL10 CXCL8
4 MHC class II receptor activity GO:0032395 9.26 HLA-DPA1 HLA-DQB1 HLA-DQB2 HLA-DRB1
5 peptide antigen binding GO:0042605 9.23 HLA-A HLA-B HLA-C HLA-DPA1 HLA-DPB1 HLA-DQB1

Sources for Glaucomatocyclitic Crisis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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