MCID: GLB011
MIFTS: 23

Glioblastoma Classical Subtype

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Glioblastoma Classical Subtype

MalaCards integrated aliases for Glioblastoma Classical Subtype:

Name: Glioblastoma Classical Subtype 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050803

Summaries for Glioblastoma Classical Subtype

Disease Ontology : 12 A glioblastoma multiforme that is characterized by abnormally high levels of epidermal growth factor receptor and the absence of p53 mutations.

MalaCards based summary : Glioblastoma Classical Subtype is related to adult brain stem glioma and central nervous system rhabdomyosarcoma. An important gene associated with Glioblastoma Classical Subtype is MGMT (O-6-Methylguanine-DNA Methyltransferase), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Mesodermal Commitment Pathway. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Glioblastoma Classical Subtype

Diseases related to Glioblastoma Classical Subtype via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 adult brain stem glioma 10.4 MGMT IDH1
2 central nervous system rhabdomyosarcoma 10.4 MGMT IDH1
3 frontal lobe neoplasm 10.3 MGMT IDH1
4 spinal cord astrocytoma 10.3 MGMT IDH1
5 temporal lobe neoplasm 10.3 MGMT IDH1
6 childhood oligodendroglioma 10.3 MGMT IDH1
7 spinal cord oligodendroglioma 10.3 MGMT IDH1
8 gemistocytic astrocytoma 10.3 MGMT IDH1
9 high-grade astrocytoma 10.3 PARP1 IDH1
10 mixed glioma 10.2 MGMT IDH1
11 waardenburg syndrome, type 2c 10.1 SNAI2 APPL1
12 waardenburg syndrome, type 4b 10.1 SNAI2 APPL1
13 ovarian embryonal carcinoma 10.0 SOX2 POU5F1
14 waardenburg syndrome, type 2e 10.0 SNAI2 APPL1
15 malignant giant cell tumor of soft parts 10.0 POU5F1 NANOG
16 giant cell glioblastoma 10.0 MGMT MDM2 IDH1
17 low-grade astrocytoma 9.9 SOX2 IDH1
18 grade iii astrocytoma 9.9 MGMT MDM2 IDH1
19 breast adenocarcinoma 9.9 PARP1 MGMT IDH1 ERBB3
20 inflammatory bowel disease 28 9.8 SOX2 POU5F1
21 meningioma, familial 9.8 PTCH2 MGMT MDM2 IDH1
22 parkinson disease 17 9.8 SOX2 POU5F1 NANOG
23 malignant teratoma 9.8 SOX2 POU5F1 NANOG
24 tyrosinemia 9.7 SOX2 POU5F1 NANOG
25 luminal breast carcinoma 9.7 SNAI2 SNAI1 ERBB3
26 germ cell and embryonal cancer 9.6 SOX2 POU5F1 NANOG FUT4
27 seminoma 9.6 SOX2 POU5F1 NANOG GJA1
28 uterine carcinosarcoma 9.6 SNAI2 SNAI1 ERBB3
29 germ cell cancer 9.5 SOX2 POU5F1 NANOG FUT4
30 central nervous system cancer 9.5 SOX2 PROM1 MGMT IDH1
31 ocular cancer 9.5 SOX2 POU5F1 MDM2
32 infratentorial cancer 9.4 SOX2 PTCH2 PROM1 MGMT IDH1
33 ewing sarcoma 9.3 SOX2 POU5F1 PARP1 MDM2
34 squamous cell carcinoma, head and neck 9.3 SNAI2 SNAI1 PARP1 MGMT ERBB3
35 gastric adenocarcinoma 9.1 SOX2 PROM1 MGMT MDM2 ERBB3
36 basal cell carcinoma 9.1 SOX2 SNAI2 PTCH2 MDM2
37 nasopharyngeal carcinoma 8.9 SOX2 SNAI2 SNAI1 PARP1 MDM2
38 adenoid cystic carcinoma 8.9 SOX2 SNAI2 SNAI1 MDM2 IDH1
39 brain cancer 8.8 SOX2 POU5F1 NANOG MGMT MDM2 IDH1
40 gliosarcoma 8.7 SOX2 SNAI2 PROM1 MGMT MDM2 IDH1
41 esophageal cancer 8.6 SOX2 SNAI2 PROM1 NANOG MGMT MDM2
42 suppression of tumorigenicity 12 8.4 SOX2 SNAI2 SNAI1 PROM1 MDM2 IDH1
43 pancreatic adenocarcinoma 8.4 SNAI1 PROM1 POU5F1 MDM2 ERBB3 EIF2AK3
44 leukemia, acute myeloid 8.4 SOX2 PROM1 POU5F1 NANOG MDM2 IDH1
45 retinitis pigmentosa 8.2 TBP SOX2 PROM1 POU5F1 NANOG MDM2
46 glioblastoma multiforme 8.2 SOX2 PROM1 PARP1 MGMT MDM2 IDH1
47 medulloblastoma 7.7 SOX2 PTCH2 PROM1 POU5F1 PARP1 NANOG
48 lung cancer susceptibility 3 7.4 SOX2 SNAI2 SNAI1 POU5F1 PARP1 NANOG
49 prostate cancer 7.3 SOX2 SNAI2 SNAI1 PROM1 POU5F1 PARP1
50 lung cancer 7.2 SOX2 SNAI2 SNAI1 PROM1 POU5F1 PARP1

Graphical network of the top 20 diseases related to Glioblastoma Classical Subtype:



Diseases related to Glioblastoma Classical Subtype

Symptoms & Phenotypes for Glioblastoma Classical Subtype

GenomeRNAi Phenotypes related to Glioblastoma Classical Subtype according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.78 ERBB3 PTCH2
2 Decreased viability GR00221-A-1 9.78 EIF2AK3 MAP3K5 PTCH2 SOX2
3 Decreased viability GR00221-A-2 9.78 EIF2AK3 ERBB3 PTCH2
4 Decreased viability GR00221-A-3 9.78 APPL1 PTCH2
5 Decreased viability GR00221-A-4 9.78 APPL1 EIF2AK3 ERBB3 MAP3K5 PTCH2 SOX2
6 Decreased viability GR00301-A 9.78 ERBB3 MAP3K5 PTCH2
7 Decreased viability GR00342-S-2 9.78 ERBB3
8 Decreased viability GR00342-S-3 9.78 ERBB3
9 Decreased viability GR00381-A-1 9.78 APPL1
10 Decreased viability GR00402-S-2 9.78 APPL1 EIF2AK3 ERBB3 MAP3K5 PTCH2 SOX2

MGI Mouse Phenotypes related to Glioblastoma Classical Subtype:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.34 APPL1 EIF2AK3 ERBB3 FUT4 GJA1 MAP3K5
2 behavior/neurological MP:0005386 10.29 APPL1 EIF2AK3 ERBB3 GJA1 MDM2 PARP1
3 cardiovascular system MP:0005385 10.28 APPL1 ERBB3 FUT4 GJA1 MAP3K5 MDM2
4 homeostasis/metabolism MP:0005376 10.27 APPL1 EIF2AK3 ERBB3 GJA1 IDH1 MAP3K5
5 growth/size/body region MP:0005378 10.26 APPL1 EIF2AK3 ERBB3 GJA1 IDH1 MDM2
6 mortality/aging MP:0010768 10.24 APPL1 EIF2AK3 ERBB3 GJA1 IDH1 MDM2
7 embryo MP:0005380 10.19 ERBB3 GJA1 MDM2 NANOG PARP1 POU5F1
8 immune system MP:0005387 10.17 APPL1 EIF2AK3 ERBB3 FUT4 GJA1 IDH1
9 digestive/alimentary MP:0005381 10.11 EIF2AK3 ERBB3 MDM2 POU5F1 PTCH2 SNAI1
10 nervous system MP:0003631 10.07 EIF2AK3 ERBB3 GJA1 MDM2 MGMT PARP1
11 integument MP:0010771 10.01 ERBB3 GJA1 MDM2 PARP1 POU5F1 PTCH2
12 neoplasm MP:0002006 9.92 EIF2AK3 ERBB3 MAP3K5 MDM2 MGMT PROM1
13 no phenotypic analysis MP:0003012 9.85 APPL1 EIF2AK3 GJA1 MDM2 MGMT NANOG
14 normal MP:0002873 9.56 ERBB3 GJA1 MDM2 POU5F1 PROM1 PTCH2
15 pigmentation MP:0001186 9.02 ERBB3 MDM2 PROM1 SNAI2 SOX2

Drugs & Therapeutics for Glioblastoma Classical Subtype

Search Clinical Trials , NIH Clinical Center for Glioblastoma Classical Subtype

Genetic Tests for Glioblastoma Classical Subtype

Anatomical Context for Glioblastoma Classical Subtype

Publications for Glioblastoma Classical Subtype

Variations for Glioblastoma Classical Subtype

Expression for Glioblastoma Classical Subtype

Search GEO for disease gene expression data for Glioblastoma Classical Subtype.

Pathways for Glioblastoma Classical Subtype

Pathways related to Glioblastoma Classical Subtype according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 SOX2 POU5F1 NANOG MAP3K5 ERBB3 EIF2AK3
2
Show member pathways
12.26 SOX2 SNAI1 POU5F1 NANOG
3 11.83 SOX2 POU5F1 NANOG GJA1
4 11.6 PARP1 MAP3K5 GJA1
5 11.56 SOX2 SNAI1 PROM1 POU5F1 NANOG GJA1
6 11.49 SOX2 SNAI2 SNAI1 PTCH2 PROM1 POU5F1
7 11.39 SOX2 POU5F1 NANOG
8 11.32 SOX2 POU5F1 NANOG
9 11.3 SOX2 POU5F1 NANOG
10
Show member pathways
11.23 SOX2 POU5F1 NANOG
11 10.75 SNAI2 SNAI1
12 10.66 SOX2 POU5F1 NANOG
13
Show member pathways
10.33 SOX2 POU5F1 NANOG

GO Terms for Glioblastoma Classical Subtype

Cellular components related to Glioblastoma Classical Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.35 TBP PARP1 MDM2 MAP3K5 GJA1
2 nucleoplasm GO:0005654 9.32 TBP SOX2 SNAI2 SNAI1 POU5F1 PARP1

Biological processes related to Glioblastoma Classical Subtype according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.88 SOX2 SNAI2 SNAI1 POU5F1 PARP1 MDM2
2 regulation of gene expression GO:0010468 9.73 SOX2 POU5F1 NANOG MDM2
3 osteoblast differentiation GO:0001649 9.71 SOX2 SNAI2 SNAI1
4 somatic stem cell population maintenance GO:0035019 9.54 SOX2 POU5F1 NANOG
5 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 9.52 SNAI2 SNAI1
6 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.51 SOX2 MGMT
7 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.49 SNAI2 SNAI1
8 positive regulation of stem cell proliferation GO:2000648 9.48 NANOG GJA1
9 Notch signaling involved in heart development GO:0061314 9.46 SNAI2 SNAI1
10 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 9.33 SNAI2 SNAI1 MDM2
11 cartilage morphogenesis GO:0060536 9.32 SNAI2 SNAI1
12 negative regulation of vitamin D biosynthetic process GO:0010957 9.26 SNAI2 SNAI1
13 regulation of bicellular tight junction assembly GO:2000810 9.13 SNAI2 SNAI1 GJA1
14 endodermal cell fate specification GO:0001714 8.8 SOX2 POU5F1 NANOG

Molecular functions related to Glioblastoma Classical Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.65 SOX2 SNAI2 SNAI1 POU5F1 NANOG
2 DNA binding GO:0003677 9.56 TBP SOX2 SNAI2 SNAI1 POU5F1 PARP1
3 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.46 SNAI2 SNAI1 PARP1 NANOG
4 identical protein binding GO:0042802 9.17 PARP1 MDM2 MAP3K5 IDH1 ERBB3 EIF2AK3

Sources for Glioblastoma Classical Subtype

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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