MCID: GLB013
MIFTS: 16

Glioblastoma Mesenchymal Subtype

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Glioblastoma Mesenchymal Subtype

MalaCards integrated aliases for Glioblastoma Mesenchymal Subtype:

Name: Glioblastoma Mesenchymal Subtype 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050805

Summaries for Glioblastoma Mesenchymal Subtype

Disease Ontology : 12 A glioblastoma multiforme that is characterized by the most frequent number of mutation of the Neurofibromin 1 gene.

MalaCards based summary : Glioblastoma Mesenchymal Subtype An important gene associated with Glioblastoma Mesenchymal Subtype is CARD6 (Caspase Recruitment Domain Family Member 6), and among its related pathways/superpathways are Akt Signaling and Ras signaling pathway. Affiliated tissues include bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Glioblastoma Mesenchymal Subtype

Symptoms & Phenotypes for Glioblastoma Mesenchymal Subtype

GenomeRNAi Phenotypes related to Glioblastoma Mesenchymal Subtype according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.7 MAPK11 MAPK13 MAPKAPK5
2 Decreased viability GR00221-A-2 9.7 MAPK11 MAPK13
3 Decreased viability GR00221-A-3 9.7 MAPK13
4 Decreased viability GR00221-A-4 9.7 MAPKAPK5
5 Decreased viability GR00301-A 9.7 MAPKAPK5
6 Decreased viability GR00402-S-2 9.7 MAPK11 MAPK13 MAPKAPK5
7 Increased transferrin (TF) endocytosis GR00363-A 9.1 CARD6 MAPK11 MAPK13 MAPKAPK5 NUBP2 PLOD1

Drugs & Therapeutics for Glioblastoma Mesenchymal Subtype

Search Clinical Trials , NIH Clinical Center for Glioblastoma Mesenchymal Subtype

Genetic Tests for Glioblastoma Mesenchymal Subtype

Anatomical Context for Glioblastoma Mesenchymal Subtype

MalaCards organs/tissues related to Glioblastoma Mesenchymal Subtype:

40
Bone

Publications for Glioblastoma Mesenchymal Subtype

Variations for Glioblastoma Mesenchymal Subtype

Expression for Glioblastoma Mesenchymal Subtype

Search GEO for disease gene expression data for Glioblastoma Mesenchymal Subtype.

Pathways for Glioblastoma Mesenchymal Subtype

Pathways related to Glioblastoma Mesenchymal Subtype according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 MAPKAPK5 MAPK13 MAPK11 ANGPT2
2
Show member pathways
12.41 MAPK13 MAPK11 ANGPT2
3
Show member pathways
12.26 MAPK13 MAPK11 ANGPT2
4
Show member pathways
11.97 MAPKAPK5 MAPK13 MAPK11
5 11.92 MAPKAPK5 MAPK13 MAPK11 ANGPT2
6 11.69 MAPK13 MAPK11 CARD6
7
Show member pathways
11.56 MAPK13 MAPK11
8 11.54 MAPK13 MAPK11
9 11.51 MAPK13 MAPK11
10 11.48 MAPK13 MAPK11
11 11.44 MAPK13 MAPK11
12 11.31 MAPK13 MAPK11
13 11.27 MAPK13 MAPK11
14 11.23 MAPK13 MAPK11
15
Show member pathways
11.18 MAPK13 MAPK11
16 11.15 MAPK13 MAPK11
17
Show member pathways
11.13 MAPK13 MAPK11
18 11.11 MAPK13 MAPK11
19
Show member pathways
11.07 MAPK13 MAPK11
20 11 MAPKAPK5 MAPK11
21 10.98 MAPK13 MAPK11
22 10.85 MAPKAPK5 MAPK13 MAPK11
23 10.8 MAPK13 MAPK11
24 10.68 MAPK13 MAPK11
25 10.27 MAPK13 MAPK11

GO Terms for Glioblastoma Mesenchymal Subtype

Biological processes related to Glioblastoma Mesenchymal Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular signal transduction GO:0035556 9.33 MAPKAPK5 MAPK13 MAPK11
2 cellular response to interleukin-1 GO:0071347 9.26 MAPK13 MAPK11
3 Ras protein signal transduction GO:0007265 8.96 MAPKAPK5 MAPK11
4 stress-activated MAPK cascade GO:0051403 8.62 MAPK13 MAPK11

Molecular functions related to Glioblastoma Mesenchymal Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein serine/threonine kinase activity GO:0004674 9.33 MAPKAPK5 MAPK13 MAPK11
2 nucleotide binding GO:0000166 9.13 NUBP2 MAPKAPK5 MAPK13
3 MAP kinase activity GO:0004707 8.62 MAPK13 MAPK11

Sources for Glioblastoma Mesenchymal Subtype

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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