Glioblastoma Neural Subtype disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GLB014 MIFTS: 20	Glioblastoma Neural Subtype Categories: Cancer diseases, Neuronal diseases
Genes Related diseases Pathways Expand all tables

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Aliases & Classifications for Glioblastoma Neural Subtype

MalaCards integrated aliases for Glioblastoma Neural Subtype:

Name: Glioblastoma Neural Subtype ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050806

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Summaries for Glioblastoma Neural Subtype

Disease Ontology : ¹² A glioblastoma multiforme that is characterized by the expression of several gene types that are also typical of the brain's normal, noncancerous nerve cells, or neurons.

MalaCards based summary : Glioblastoma Neural Subtype is related to myeloid and lymphoid neoplasms associated with fgfr1 abnormalities and crisponi/cold-induced sweating syndrome 2. An important gene associated with Glioblastoma Neural Subtype is STAT5B (Signal Transducer And Activator Of Transcription 5B), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. Related phenotype is liver/biliary system.

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Related Diseases for Glioblastoma Neural Subtype

Diseases related to Glioblastoma Neural Subtype via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)

#	Related Disease	Score	Top Affiliating Genes
1	myeloid and lymphoid neoplasms associated with fgfr1 abnormalities	10.1	STAT5B STAT5A
2	crisponi/cold-induced sweating syndrome 2	10.1	STAT5B STAT5A
3	myelodysplastic/myeloproliferative neoplasm	10.1	STAT5B STAT5A
4	erythrocytosis, familial, 1	10.1	STAT5B STAT5A
5	primary polycythemia	10.1	STAT5B STAT5A
6	polycythemia	10.0	STAT5B STAT5A
7	t-cell large granular lymphocyte leukemia	10.0	STAT5B IL2
8	chronic leukemia	10.0	STAT5B STAT5A
9	systemic mastocytosis	10.0	STAT5B STAT5A
10	mastocytosis	10.0	STAT5B STAT5A
11	thymus cancer	9.8	NKX2-1 IL2
12	thyroiditis	9.7	NKX2-1 IL2
13	ophthalmia nodosa	9.7	RPS3A PSMD4
14	jak3-deficient severe combined immunodeficiency	9.7	STAT5B STAT5A IL2
15	severe combined immunodeficiency	9.7	STAT5B STAT5A IL2
16	immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	9.7	STAT5B STAT5A IL2
17	sezary's disease	9.7	STAT5B STAT5A IL2
18	griscelli syndrome, type 3	9.7	RPS3A PSMD4
19	retinitis pigmentosa 23	9.6	RPS3A PSMD4
20	hematologic cancer	9.5	STAT5B STAT5A IL2
21	severe congenital neutropenia	9.5	STAT5A IL2
22	pelizaeus-merzbacher disease	9.5	RPS3A PSMD4
23	wilson-turner x-linked mental retardation syndrome	9.5	RPS3A PSMD4
24	t-cell leukemia	9.4	STAT5B STAT5A IL2
25	hypotrichosis 1	9.3	RPS3A PSMD4 IL2
26	myeloma, multiple	9.3	STAT5B STAT5A RPS3A IL2
27	leukemia, acute myeloid	8.7	STAT5B STAT5A RPS3A PSMD4 IL2

Graphical network of the top 20 diseases related to Glioblastoma Neural Subtype:

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Symptoms & Phenotypes for Glioblastoma Neural Subtype

MGI Mouse Phenotypes related to Glioblastoma Neural Subtype:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system	MP:0005370	8.92	IL2 PSMD4 STAT5A STAT5B

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Drugs & Therapeutics for Glioblastoma Neural Subtype

Search Clinical Trials , NIH Clinical Center for Glioblastoma Neural Subtype

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Genetic Tests for Glioblastoma Neural Subtype

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Anatomical Context for Glioblastoma Neural Subtype

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Publications for Glioblastoma Neural Subtype

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Genes for Glioblastoma Neural Subtype

Genes related to Glioblastoma Neural Subtype (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	5.23	DISEASES inferred ¹⁵
2	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	5.23	DISEASES inferred ¹⁵
3	IL2	Interleukin 2	Protein Coding	4.34	DISEASES inferred ¹⁵
4	NKX2-1	NK2 Homeobox 1	Protein Coding	4.17	DISEASES inferred ¹⁵
5	PSMD4	Proteasome 26S Subunit, Non-ATPase 4	Protein Coding	3.83	DISEASES inferred ¹⁵
6	RPS3A	Ribosomal Protein S3A	Protein Coding	3.57	DISEASES inferred ¹⁵

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Variations for Glioblastoma Neural Subtype

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Expression for Glioblastoma Neural Subtype

Search GEO for disease gene expression data for Glioblastoma Neural Subtype.

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Pathways for Glioblastoma Neural Subtype

Pathways related to Glioblastoma Neural Subtype according to GeneCards Suite gene sharing:

(show all 37)

#	Super pathways	Score	Top Affiliating Genes
1	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.05	STAT5B STAT5A PSMD4 IL2
2	Pathways in cancer ³⁶	12.56	STAT5B STAT5A IL2
3	Beta-Adrenergic Signaling ⁶³ Show member pathways CDK5 Pathway ⁶³ Erythropoietin Pathway ⁶³ Insulin Receptor Pathway ⁶³	12.53	STAT5B STAT5A PSMD4
4	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁴ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁴ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁴ IL-2 Signaling Pathways ⁶⁴ IL-21 Signaling Pathways ⁶⁴ IL-4 Signaling Pathways ⁶⁴ IL-7 Signaling Pathways ⁶⁴ IL-9 Pathway ⁶³ IL-9 Signaling Pathways ⁶⁴ Immune response IL-9 signaling pathway ²²	12.5	STAT5B STAT5A IL2
5	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁶ Th1 and Th2 cell differentiation ³⁶	12.32	STAT5B STAT5A IL2
6	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.31	STAT5B STAT5A IL2
7	NF-kappaB Signaling ⁴	12.28	STAT5B STAT5A IL2
8	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.26	STAT5B STAT5A PSMD4 IL2
9	Human T-cell leukemia virus 1 infection ³⁶	11.99	STAT5B STAT5A IL2
10	JAK-STAT signaling pathway (KEGG) ³⁶ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴	11.97	STAT5B STAT5A IL2
11	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.67	STAT5B STAT5A
12	IL-2 Signaling Pathway ¹ Show member pathways IL2-mediated signaling events ¹ IL-5 Signaling Pathway ¹	11.67	STAT5B STAT5A IL2
13	Development EPO-induced Jak-STAT pathway ²² Show member pathways EPO Receptor Signaling ¹ EPO signaling pathway ¹	11.66	STAT5B STAT5A
14	FGFR1 mutant receptor activation ⁶⁵ Show member pathways Signaling by cytosolic FGFR1 fusion mutants ⁶⁵ Signaling by FGFR1 in disease ⁶⁵ Signaling by plasma membrane FGFR1 fusions ⁶⁵	11.62	STAT5B STAT5A
15	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁴	11.61	STAT5B STAT5A IL2
16	Immune response IL-2 activation and signaling pathway ²² Show member pathways Immune response IL-3 activation and signaling pathway ²²	11.6	STAT5B STAT5A
17	CXCR4-mediated signaling events ¹	11.54	STAT5B STAT5A
18	Jak-Stat Signaling Pathway (sino) ⁶⁶	11.52	STAT5B STAT5A IL2
19	AGE/RAGE pathway ¹	11.47	STAT5B STAT5A
20	IL4-mediated signaling events ¹	11.44	STAT5B STAT5A
21	PDGFR-beta signaling pathway ¹	11.37	STAT5B STAT5A
22	Signaling events mediated by PTP1B ¹	11.33	STAT5B STAT5A
23	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.29	STAT5B STAT5A
24	Th2 Differentiation Pathway ⁶⁴	11.28	STAT5A IL2
25	IL-7 Signaling Pathway ¹ Show member pathways B-Cell Development ⁶³ IL-9 Signaling Pathway ¹	11.27	STAT5B STAT5A
26	Signaling events mediated by TCPTP ¹ Show member pathways MET activates PI3K/AKT signaling ⁶⁵	11.21	STAT5B STAT5A
27	Growth hormone receptor signaling ⁶⁵ Show member pathways Prolactin receptor signaling ⁶⁵	11.18	STAT5B STAT5A
28	Development_Glucocorticoid receptor signaling ²²	11.17	STAT5B STAT5A
29	Jak/STAT Signaling Pathway Intracellular Regulation ⁶⁴	11.15	STAT5B STAT5A
30	Type III Interferon Signaling Pathways ⁶⁴ Show member pathways Type III interferon signaling ¹	11.13	STAT5B STAT5A
31	Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.1	STAT5B STAT5A
32	Glucocorticoid receptor regulatory network ¹	11.05	STAT5B STAT5A IL2
33	Immune response_IL-12 signaling pathway ²² Show member pathways Interleukin-12 signaling ⁶⁵	10.97	STAT5B STAT5A
34	Interleukin-7 signaling ⁶⁵	10.94	STAT5B STAT5A
35	Immune response_Oncostatin M signaling via JAK-Stat in human cells ²²	10.74	STAT5B STAT5A
36	Telomere Extension by Telomerase ⁶³ Show member pathways XAV939 inhibits tankyrase, stabilizing AXIN ⁶⁵	10.65	STAT5B STAT5A IL2
37	IL2 signaling events mediated by PI3K ¹ Show member pathways IL2 signaling events mediated by STAT5 ¹	10.63	STAT5B STAT5A IL2

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GO Terms for Glioblastoma Neural Subtype

Biological processes related to Glioblastoma Neural Subtype according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.81	STAT5B STAT5A NKX2-1 IL2
2	negative regulation of apoptotic process	GO:0043066	9.72	STAT5B RPS3A IL2
3	cytokine-mediated signaling pathway	GO:0019221	9.65	STAT5B STAT5A IL2
4	positive regulation of inflammatory response	GO:0050729	9.54	STAT5B IL2
5	response to peptide hormone	GO:0043434	9.52	STAT5B STAT5A
6	lactation	GO:0007595	9.49	STAT5B STAT5A
7	interleukin-7-mediated signaling pathway	GO:0038111	9.46	STAT5B STAT5A
8	JAK-STAT cascade	GO:0007259	9.43	STAT5B STAT5A
9	regulation of multicellular organism growth	GO:0040014	9.4	STAT5B STAT5A
10	positive regulation of activated T cell proliferation	GO:0042104	9.37	STAT5B IL2
11	JAK-STAT cascade involved in growth hormone signaling pathway	GO:0060397	9.32	STAT5B STAT5A
12	interleukin-15-mediated signaling pathway	GO:0035723	9.26	STAT5B STAT5A
13	interleukin-9-mediated signaling pathway	GO:0038113	9.16	STAT5B STAT5A
14	taurine metabolic process	GO:0019530	8.96	STAT5B STAT5A
15	interleukin-2-mediated signaling pathway	GO:0038110	8.8	STAT5B STAT5A IL2

Molecular functions related to Glioblastoma Neural Subtype according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	RNA polymerase II proximal promoter sequence-specific DNA binding	GO:0000978	8.8	STAT5B STAT5A NKX2-1

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Sources for Glioblastoma Neural Subtype

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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¹⁰ dbSNP

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

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⁴³ MeSH

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⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

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⁶¹ PubMed

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⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

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⁷¹ UMLS

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⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia