MCID: GLB014
MIFTS: 20

Glioblastoma Neural Subtype

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Glioblastoma Neural Subtype

MalaCards integrated aliases for Glioblastoma Neural Subtype:

Name: Glioblastoma Neural Subtype 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050806

Summaries for Glioblastoma Neural Subtype

Disease Ontology : 12 A glioblastoma that is characterized by the expression of several gene types that are also typical of the brain's normal, noncancerous nerve cells, or neurons.

MalaCards based summary : Glioblastoma Neural Subtype is related to myeloid and lymphoid neoplasms associated with fgfr1 abnormalities and crisponi/cold-induced sweating syndrome 2. An important gene associated with Glioblastoma Neural Subtype is STAT5A (Signal Transducer And Activator Of Transcription 5A), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Pathways in cancer. Related phenotypes are endocrine/exocrine gland and reproductive system

Related Diseases for Glioblastoma Neural Subtype

Diseases related to Glioblastoma Neural Subtype via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.0 STAT5B STAT5A
2 crisponi/cold-induced sweating syndrome 2 9.9 STAT5B STAT5A
3 erythrocytosis, familial, 1 9.9 STAT5B STAT5A
4 myelodysplastic/myeloproliferative neoplasm 9.9 STAT5B STAT5A
5 myeloproliferative neoplasm 9.9 STAT5B STAT5A
6 chronic eosinophilic leukemia 9.9 STAT5B STAT5A
7 chronic leukemia 9.9 STAT5B STAT5A
8 systemic mastocytosis 9.9 STAT5B STAT5A
9 mastocytosis 9.9 STAT5B STAT5A
10 childhood leukemia 9.9 STAT5B STAT5A
11 bone marrow cancer 9.8 STAT5B STAT5A
12 thymus cancer 9.8 NKX2-1 IL2
13 t-cell large granular lymphocyte leukemia 9.8 STAT5B IL2
14 lymphopenia 9.8 STAT5A IL2
15 mature t-cell and nk-cell lymphoma 9.8 STAT5B IL2
16 peripheral t-cell lymphoma 9.8 STAT5A IL2
17 polycythemia vera 9.7 STAT5B STAT5A
18 thymoma 9.7 NKX2-1 IL2
19 chronic mucocutaneous candidiasis 9.7 STAT5B IL2
20 cutaneous t cell lymphoma 9.7 STAT5A IL2
21 hypereosinophilic syndrome 9.7 STAT5B IL2
22 severe congenital neutropenia 9.6 STAT5A IL2
23 essential thrombocythemia 9.6 STAT5B STAT5A
24 jak3-deficient severe combined immunodeficiency 9.5 STAT5B STAT5A IL2
25 severe combined immunodeficiency 9.5 STAT5B STAT5A IL2
26 combined immunodeficiency 9.5 STAT5B STAT5A IL2
27 immunodeficiency 41 with lymphoproliferation and autoimmunity 9.5 STAT5B STAT5A IL2
28 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.5 STAT5B STAT5A IL2
29 sezary's disease 9.5 STAT5B STAT5A IL2
30 t-cell acute lymphoblastic leukemia 9.5 STAT5B STAT5A IL2
31 hematologic cancer 9.5 STAT5B STAT5A IL2
32 immune deficiency disease 9.5 STAT5B STAT5A IL2
33 leukemia, acute lymphoblastic 9.5 STAT5B STAT5A IL2
34 myelodysplastic syndrome 9.4 STAT5B STAT5A IL2
35 leukemia, acute myeloid 9.4 STAT5B STAT5A IL2

Graphical network of the top 20 diseases related to Glioblastoma Neural Subtype:



Diseases related to Glioblastoma Neural Subtype

Symptoms & Phenotypes for Glioblastoma Neural Subtype

MGI Mouse Phenotypes related to Glioblastoma Neural Subtype:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.26 IL2 NKX2-1 STAT5A STAT5B
2 reproductive system MP:0005389 8.92 IL2 NKX2-1 STAT5A STAT5B

Drugs & Therapeutics for Glioblastoma Neural Subtype

Search Clinical Trials , NIH Clinical Center for Glioblastoma Neural Subtype

Genetic Tests for Glioblastoma Neural Subtype

Anatomical Context for Glioblastoma Neural Subtype

Publications for Glioblastoma Neural Subtype

Variations for Glioblastoma Neural Subtype

Expression for Glioblastoma Neural Subtype

Search GEO for disease gene expression data for Glioblastoma Neural Subtype.

Pathways for Glioblastoma Neural Subtype

Pathways related to Glioblastoma Neural Subtype according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 STAT5B STAT5A IL2
2 12.53 STAT5B STAT5A IL2
3
Show member pathways
12.51 STAT5B STAT5A IL2
4
Show member pathways
12.47 STAT5B STAT5A IL2
5
Show member pathways
12.25 STAT5B STAT5A IL2
6
Show member pathways
12.23 STAT5B STAT5A IL2
7 12.2 STAT5B STAT5A IL2
8
Show member pathways
12.03 STAT5B STAT5A IL2
9
Show member pathways
11.92 STAT5B STAT5A
10 11.92 STAT5B STAT5A IL2
11 11.91 STAT5B STAT5A
12
Show member pathways
11.89 STAT5B STAT5A
13
Show member pathways
11.88 STAT5B STAT5A
14 11.84 STAT5B STAT5A
15 11.8 STAT5B STAT5A
16
Show member pathways
11.73 STAT5A IL2
17
Show member pathways
11.7 STAT5B STAT5A
18
Show member pathways
11.67 STAT5B STAT5A IL2
19 11.66 STAT5B STAT5A
20 11.65 STAT5B STAT5A
21
Show member pathways
11.65 STAT5B STAT5A
22
Show member pathways
11.61 STAT5B STAT5A
23
Show member pathways
11.6 STAT5B STAT5A
24
Show member pathways
11.6 STAT5B STAT5A
25 11.53 STAT5B STAT5A
26 11.46 STAT5B STAT5A
27 11.44 STAT5B STAT5A
28 11.36 STAT5B STAT5A
29 11.35 STAT5B STAT5A IL2
30 11.31 STAT5B STAT5A
31 11.28 STAT5B STAT5A
32 11.26 STAT5A IL2
33
Show member pathways
11.23 STAT5B STAT5A
34
Show member pathways
11.21 STAT5B STAT5A
35
Show member pathways
11.21 STAT5B STAT5A IL2
36
Show member pathways
11.18 STAT5B STAT5A
37 11.17 STAT5B STAT5A
38 11.13 STAT5B STAT5A
39 10.99 STAT5B STAT5A IL2
40
Show member pathways
10.96 STAT5B STAT5A
41 10.92 STAT5B STAT5A
42
Show member pathways
10.82 STAT5B STAT5A IL2
43 10.71 STAT5B STAT5A
44
Show member pathways
10.63 STAT5B STAT5A IL2

GO Terms for Glioblastoma Neural Subtype

Biological processes related to Glioblastoma Neural Subtype according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 defense response GO:0006952 9.54 STAT5B STAT5A
2 cytokine-mediated signaling pathway GO:0019221 9.54 STAT5B STAT5A IL2
3 positive regulation of inflammatory response GO:0050729 9.52 STAT5B IL2
4 response to peptide hormone GO:0043434 9.51 STAT5B STAT5A
5 lactation GO:0007595 9.49 STAT5B STAT5A
6 JAK-STAT cascade GO:0007259 9.48 STAT5B STAT5A
7 interleukin-7-mediated signaling pathway GO:0038111 9.46 STAT5B STAT5A
8 positive regulation of activated T cell proliferation GO:0042104 9.43 STAT5B IL2
9 regulation of multicellular organism growth GO:0040014 9.4 STAT5B STAT5A
10 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.32 STAT5B STAT5A
11 interleukin-15-mediated signaling pathway GO:0035723 9.26 STAT5B STAT5A
12 interleukin-9-mediated signaling pathway GO:0038113 9.16 STAT5B STAT5A
13 taurine metabolic process GO:0019530 8.96 STAT5B STAT5A
14 interleukin-2-mediated signaling pathway GO:0038110 8.8 STAT5B STAT5A IL2

Molecular functions related to Glioblastoma Neural Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 8.8 STAT5B STAT5A NKX2-1

Sources for Glioblastoma Neural Subtype

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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