Glioblastoma Neural Subtype disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GLB014 MIFTS: 20	Glioblastoma Neural Subtype Categories: Bone diseases, Cancer diseases, Neuronal diseases
Genes Related diseases Pathways Expand all tables

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Aliases & Classifications for Glioblastoma Neural Subtype

MalaCards integrated aliases for Glioblastoma Neural Subtype:

Name: Glioblastoma Neural Subtype ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050806

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Summaries for Glioblastoma Neural Subtype

Disease Ontology : ¹² A glioblastoma that is characterized by the expression of several gene types that are also typical of the brain's normal, noncancerous nerve cells, or neurons.

MalaCards based summary : Glioblastoma Neural Subtype is related to myeloid and lymphoid neoplasms associated with fgfr1 abnormalities and crisponi/cold-induced sweating syndrome 2. An important gene associated with Glioblastoma Neural Subtype is STAT5A (Signal Transducer And Activator Of Transcription 5A), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Pathways in cancer. Related phenotypes are endocrine/exocrine gland and reproductive system

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Related Diseases for Glioblastoma Neural Subtype

Diseases related to Glioblastoma Neural Subtype via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)

#	Related Disease	Score	Top Affiliating Genes
1	myeloid and lymphoid neoplasms associated with fgfr1 abnormalities	10.0	STAT5B STAT5A
2	crisponi/cold-induced sweating syndrome 2	9.9	STAT5B STAT5A
3	erythrocytosis, familial, 1	9.9	STAT5B STAT5A
4	myelodysplastic/myeloproliferative neoplasm	9.9	STAT5B STAT5A
5	myeloproliferative neoplasm	9.9	STAT5B STAT5A
6	chronic eosinophilic leukemia	9.9	STAT5B STAT5A
7	chronic leukemia	9.9	STAT5B STAT5A
8	systemic mastocytosis	9.9	STAT5B STAT5A
9	mastocytosis	9.9	STAT5B STAT5A
10	childhood leukemia	9.9	STAT5B STAT5A
11	bone marrow cancer	9.8	STAT5B STAT5A
12	thymus cancer	9.8	NKX2-1 IL2
13	t-cell large granular lymphocyte leukemia	9.8	STAT5B IL2
14	lymphopenia	9.8	STAT5A IL2
15	mature t-cell and nk-cell lymphoma	9.8	STAT5B IL2
16	peripheral t-cell lymphoma	9.8	STAT5A IL2
17	polycythemia vera	9.7	STAT5B STAT5A
18	thymoma	9.7	NKX2-1 IL2
19	chronic mucocutaneous candidiasis	9.7	STAT5B IL2
20	cutaneous t cell lymphoma	9.7	STAT5A IL2
21	hypereosinophilic syndrome	9.7	STAT5B IL2
22	severe congenital neutropenia	9.6	STAT5A IL2
23	essential thrombocythemia	9.6	STAT5B STAT5A
24	jak3-deficient severe combined immunodeficiency	9.5	STAT5B STAT5A IL2
25	severe combined immunodeficiency	9.5	STAT5B STAT5A IL2
26	combined immunodeficiency	9.5	STAT5B STAT5A IL2
27	immunodeficiency 41 with lymphoproliferation and autoimmunity	9.5	STAT5B STAT5A IL2
28	immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	9.5	STAT5B STAT5A IL2
29	sezary's disease	9.5	STAT5B STAT5A IL2
30	t-cell acute lymphoblastic leukemia	9.5	STAT5B STAT5A IL2
31	hematologic cancer	9.5	STAT5B STAT5A IL2
32	immune deficiency disease	9.5	STAT5B STAT5A IL2
33	leukemia, acute lymphoblastic	9.5	STAT5B STAT5A IL2
34	myelodysplastic syndrome	9.4	STAT5B STAT5A IL2
35	leukemia, acute myeloid	9.4	STAT5B STAT5A IL2

Graphical network of the top 20 diseases related to Glioblastoma Neural Subtype:

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Symptoms & Phenotypes for Glioblastoma Neural Subtype

MGI Mouse Phenotypes related to Glioblastoma Neural Subtype:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.26	IL2 NKX2-1 STAT5A STAT5B
2	reproductive system	MP:0005389	8.92	IL2 NKX2-1 STAT5A STAT5B

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Drugs & Therapeutics for Glioblastoma Neural Subtype

Search Clinical Trials , NIH Clinical Center for Glioblastoma Neural Subtype

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Genetic Tests for Glioblastoma Neural Subtype

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Anatomical Context for Glioblastoma Neural Subtype

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Publications for Glioblastoma Neural Subtype

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Genes for Glioblastoma Neural Subtype

Genes related to Glioblastoma Neural Subtype (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	5.2	DISEASES inferred ¹⁵
2	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	5.2	DISEASES inferred ¹⁵
3	IL2	Interleukin 2	Protein Coding	4.3	DISEASES inferred ¹⁵
4	NKX2-1	NK2 Homeobox 1	Protein Coding	4.18	DISEASES inferred ¹⁵

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Variations for Glioblastoma Neural Subtype

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Expression for Glioblastoma Neural Subtype

Search GEO for disease gene expression data for Glioblastoma Neural Subtype.

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Pathways for Glioblastoma Neural Subtype

Pathways related to Glioblastoma Neural Subtype according to GeneCards Suite gene sharing:

(show all 44)

#	Super pathways	Score	Top Affiliating Genes
1	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	12.73	STAT5B STAT5A IL2
2	Pathways in cancer ³⁶	12.53	STAT5B STAT5A IL2
3	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.51	STAT5B STAT5A IL2
4	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁴ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁴ Development Thrombopoietin-regulated cell processes ²³ IL-15 Signaling Pathways ⁶⁴ IL-2 Signaling Pathways ⁶⁴ IL-21 Signaling Pathways ⁶⁴ IL-4 Signaling Pathways ⁶⁴ IL-7 Signaling Pathways ⁶⁴ IL-9 Pathway ⁶³ IL-9 Signaling Pathways ⁶⁴ Immune response IL-9 signaling pathway ²³	12.47	STAT5B STAT5A IL2
5	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease ³⁶ Th1 and Th2 cell differentiation ³⁶	12.25	STAT5B STAT5A IL2
6	Immune response IL-23 signaling pathway ²³ Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²³ Development PDGF signaling via STATs and NF-kB ²³ IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²³ Rac1/Pak1/p38/MMP-2 pathway ¹	12.23	STAT5B STAT5A IL2
7	NF-kappaB Signaling ⁴	12.2	STAT5B STAT5A IL2
8	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.03	STAT5B STAT5A IL2
9	Necroptosis ³⁶ Show member pathways Nanoparticle triggered regulated necrosis ¹	11.92	STAT5B STAT5A
10	Human T-cell leukemia virus 1 infection ³⁶	11.92	STAT5B STAT5A IL2
11	EGF/EGFR Signaling Pathway ¹	11.91	STAT5B STAT5A
12	Kit receptor signaling pathway ¹ Show member pathways IL-3 Signaling Pathway ¹ Signaling events mediated by Stem cell factor receptor (c-Kit) ¹	11.89	STAT5B STAT5A
13	Signaling by FGFR2 in disease ⁶⁵ Show member pathways FGFR2 mutant receptor activation ⁶⁵ Signaling by FGFR in disease ⁶⁵ Signaling by FGFR2 IIIa TM ⁶⁵	11.88	STAT5B STAT5A
14	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway ¹	11.84	STAT5B STAT5A
15	Adipogenesis ¹	11.8	STAT5B STAT5A
16	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²³	11.73	STAT5A IL2
17	Signaling by ERBB4 ⁶⁵ Show member pathways Downregulation of ERBB4 signaling ⁶⁵ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁵	11.7	STAT5B STAT5A
18	IL-2 Signaling Pathway ¹ Show member pathways IL2-mediated signaling events ¹ IL-5 Signaling Pathway ¹	11.67	STAT5B STAT5A IL2
19	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.66	STAT5B STAT5A
20	Visual Cycle in Retinal Rods ⁶³	11.65	STAT5B STAT5A
21	Development EPO-induced Jak-STAT pathway ²³ Show member pathways EPO Receptor Signaling ¹ EPO signaling pathway ¹	11.65	STAT5B STAT5A
22	Th17 Differentiation Pathway ⁶⁴ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.61	STAT5B STAT5A
23	FGFR1 mutant receptor activation ⁶⁵ Show member pathways Signaling by cytosolic FGFR1 fusion mutants ⁶⁵ Signaling by FGFR1 in disease ⁶⁵ Signaling by plasma membrane FGFR1 fusions ⁶⁵	11.6	STAT5B STAT5A
24	Immune response IL-2 activation and signaling pathway ²³ Show member pathways Immune response IL-3 activation and signaling pathway ²³	11.6	STAT5B STAT5A
25	CXCR4-mediated signaling events ¹	11.53	STAT5B STAT5A
26	AGE/RAGE pathway ¹	11.46	STAT5B STAT5A
27	IL4-mediated signaling events ¹	11.44	STAT5B STAT5A
28	PDGFR-beta signaling pathway ¹	11.36	STAT5B STAT5A
29	Glucocorticoid receptor regulatory network ¹	11.35	STAT5B STAT5A IL2
30	Signaling events mediated by PTP1B ¹	11.31	STAT5B STAT5A
31	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.28	STAT5B STAT5A
32	Th2 Differentiation Pathway ⁶⁴	11.26	STAT5A IL2
33	IL-7 Signaling Pathway ¹ Show member pathways IL-9 Signaling Pathway ¹	11.23	STAT5B STAT5A
34	Signaling events mediated by TCPTP ¹ Show member pathways MET activates PI3K/AKT signaling ⁶⁵	11.21	STAT5B STAT5A
35	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.21	STAT5B STAT5A IL2
36	Growth hormone receptor signaling ⁶⁵ Show member pathways Prolactin receptor signaling ⁶⁵	11.18	STAT5B STAT5A
37	Development_Glucocorticoid receptor signaling ²³	11.17	STAT5B STAT5A
38	Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics ⁶⁰	11.13	STAT5B STAT5A
39	Commom Cytokine Receptor G Chain Siganaling Pathway ⁶⁶	10.99	STAT5B STAT5A IL2
40	Immune response_IL-12 signaling pathway ²³ Show member pathways Interleukin-12 signaling ⁶⁵	10.96	STAT5B STAT5A
41	Interleukin-7 signaling ⁶⁵	10.92	STAT5B STAT5A
42	Telomere Extension by Telomerase ⁶³ Show member pathways XAV939 inhibits tankyrase, stabilizing AXIN ⁶⁵	10.82	STAT5B STAT5A IL2
43	Immune response_Oncostatin M signaling via JAK-Stat in human cells ²³	10.71	STAT5B STAT5A
44	IL2 signaling events mediated by PI3K ¹ Show member pathways IL2 signaling events mediated by STAT5 ¹	10.63	STAT5B STAT5A IL2

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GO Terms for Glioblastoma Neural Subtype

Biological processes related to Glioblastoma Neural Subtype according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	defense response	GO:0006952	9.54	STAT5B STAT5A
2	cytokine-mediated signaling pathway	GO:0019221	9.54	STAT5B STAT5A IL2
3	positive regulation of inflammatory response	GO:0050729	9.52	STAT5B IL2
4	response to peptide hormone	GO:0043434	9.51	STAT5B STAT5A
5	lactation	GO:0007595	9.49	STAT5B STAT5A
6	JAK-STAT cascade	GO:0007259	9.48	STAT5B STAT5A
7	interleukin-7-mediated signaling pathway	GO:0038111	9.46	STAT5B STAT5A
8	positive regulation of activated T cell proliferation	GO:0042104	9.43	STAT5B IL2
9	regulation of multicellular organism growth	GO:0040014	9.4	STAT5B STAT5A
10	JAK-STAT cascade involved in growth hormone signaling pathway	GO:0060397	9.32	STAT5B STAT5A
11	interleukin-15-mediated signaling pathway	GO:0035723	9.26	STAT5B STAT5A
12	interleukin-9-mediated signaling pathway	GO:0038113	9.16	STAT5B STAT5A
13	taurine metabolic process	GO:0019530	8.96	STAT5B STAT5A
14	interleukin-2-mediated signaling pathway	GO:0038110	8.8	STAT5B STAT5A IL2

Molecular functions related to Glioblastoma Neural Subtype according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	DNA-binding transcription factor activity	GO:0003700	8.8	STAT5B STAT5A NKX2-1

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Sources for Glioblastoma Neural Subtype

¹ BioSystems

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³ CDC

⁴ Cell Signaling Technology

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²³ GeneGo (Thomson Reuters)

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²⁵ GeneReviews

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²⁷ GEO DataSets

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³² ICD10

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³⁶ KEGG

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³⁸ LncRNADisease

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⁴⁰ MalaCards

⁴¹ MedGen

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⁴³ MedlinePlus Genetics

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⁴⁸ NCBI Bookshelf

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⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

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⁶¹ PubMed

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⁶⁷ SNOMED-CT

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⁶⁹ TGDB

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⁷¹ UMLS

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⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia