MCID: GLB014
MIFTS: 22

Glioblastoma Neural Subtype

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Glioblastoma Neural Subtype

MalaCards integrated aliases for Glioblastoma Neural Subtype:

Name: Glioblastoma Neural Subtype 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050806

Summaries for Glioblastoma Neural Subtype

Disease Ontology : 12 A glioblastoma multiforme that is characterized by the expression of several gene types that are also typical of the brain's normal, noncancerous nerve cells, or neurons.

MalaCards based summary : Glioblastoma Neural Subtype is related to myeloid and lymphoid neoplasms associated with fgfr1 abnormalities and crisponi/cold-induced sweating syndrome 2. An important gene associated with Glioblastoma Neural Subtype is STAT5B (Signal Transducer And Activator Of Transcription 5B), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. Affiliated tissues include bone, myeloid and t cells, and related phenotype is liver/biliary system.

Related Diseases for Glioblastoma Neural Subtype

Diseases related to Glioblastoma Neural Subtype via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.1 STAT5B STAT5A
2 crisponi/cold-induced sweating syndrome 2 10.1 STAT5B STAT5A
3 myelodysplastic/myeloproliferative neoplasm 10.1 STAT5B STAT5A
4 erythrocytosis, familial, 1 10.1 STAT5B STAT5A
5 primary polycythemia 10.1 STAT5B STAT5A
6 polycythemia 10.1 STAT5B STAT5A
7 t-cell large granular lymphocyte leukemia 10.0 STAT5B IL2
8 chronic leukemia 10.0 STAT5B STAT5A
9 systemic mastocytosis 10.0 STAT5B STAT5A
10 mastocytosis 10.0 STAT5B STAT5A
11 thymus cancer 9.8 NKX2-1 IL2
12 thyroiditis 9.8 NKX2-1 IL2
13 ophthalmia nodosa 9.7 RPS3A PSMD4
14 jak3-deficient severe combined immunodeficiency 9.7 STAT5B STAT5A IL2
15 severe combined immunodeficiency 9.7 STAT5B STAT5A IL2
16 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.7 STAT5B STAT5A IL2
17 sezary's disease 9.7 STAT5B STAT5A IL2
18 griscelli syndrome, type 3 9.7 RPS3A PSMD4
19 severe congenital neutropenia 9.7 STAT5A IL2
20 retinitis pigmentosa 23 9.7 RPS3A PSMD4
21 bone marrow cancer 9.6 STAT5B STAT5A
22 pelizaeus-merzbacher disease 9.6 RPS3A PSMD4
23 hematologic cancer 9.5 STAT5B STAT5A IL2
24 wilson-turner x-linked mental retardation syndrome 9.5 RPS3A PSMD4
25 t-cell leukemia 9.4 STAT5B STAT5A IL2
26 hypotrichosis 1 9.4 RPS3A PSMD4 IL2
27 myeloma, multiple 9.3 STAT5B STAT5A RPS3A IL2
28 leukemia, acute myeloid 8.7 STAT5B STAT5A RPS3A PSMD4 IL2

Graphical network of the top 20 diseases related to Glioblastoma Neural Subtype:



Diseases related to Glioblastoma Neural Subtype

Symptoms & Phenotypes for Glioblastoma Neural Subtype

MGI Mouse Phenotypes related to Glioblastoma Neural Subtype:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.92 IL2 PSMD4 STAT5A STAT5B

Drugs & Therapeutics for Glioblastoma Neural Subtype

Search Clinical Trials , NIH Clinical Center for Glioblastoma Neural Subtype

Genetic Tests for Glioblastoma Neural Subtype

Anatomical Context for Glioblastoma Neural Subtype

MalaCards organs/tissues related to Glioblastoma Neural Subtype:

40
Bone, Myeloid, T Cells, Bone Marrow, Thymus, Thyroid

Publications for Glioblastoma Neural Subtype

Variations for Glioblastoma Neural Subtype

Expression for Glioblastoma Neural Subtype

Search GEO for disease gene expression data for Glioblastoma Neural Subtype.

Pathways for Glioblastoma Neural Subtype

Pathways related to Glioblastoma Neural Subtype according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 STAT5B STAT5A PSMD4 IL2
2 12.56 STAT5B STAT5A IL2
3
Show member pathways
12.53 STAT5B STAT5A PSMD4
4
Show member pathways
12.5 STAT5B STAT5A IL2
5
Show member pathways
12.32 STAT5B STAT5A IL2
6
Show member pathways
12.31 STAT5B STAT5A IL2
7 12.28 STAT5B STAT5A IL2
8
Show member pathways
12.26 STAT5B STAT5A PSMD4 IL2
9 11.99 STAT5B STAT5A IL2
10
Show member pathways
11.97 STAT5B STAT5A IL2
11 11.67 STAT5B STAT5A
12
Show member pathways
11.67 STAT5B STAT5A IL2
13
Show member pathways
11.66 STAT5B STAT5A
14
Show member pathways
11.62 STAT5B STAT5A
15
Show member pathways
11.61 STAT5B STAT5A IL2
16
Show member pathways
11.6 STAT5B STAT5A
17 11.54 STAT5B STAT5A
18 11.52 STAT5B STAT5A IL2
19 11.47 STAT5B STAT5A
20 11.44 STAT5B STAT5A
21 11.37 STAT5B STAT5A
22 11.33 STAT5B STAT5A
23 11.29 STAT5B STAT5A
24 11.28 STAT5A IL2
25
Show member pathways
11.27 STAT5B STAT5A
26
Show member pathways
11.21 STAT5B STAT5A
27
Show member pathways
11.18 STAT5B STAT5A
28 11.17 STAT5B STAT5A
29 11.15 STAT5B STAT5A
30
Show member pathways
11.13 STAT5B STAT5A
31 11.1 STAT5B STAT5A
32 11.05 STAT5B STAT5A IL2
33
Show member pathways
10.97 STAT5B STAT5A
34 10.94 STAT5B STAT5A
35 10.74 STAT5B STAT5A
36
Show member pathways
10.65 STAT5B STAT5A IL2
37
Show member pathways
10.63 STAT5B STAT5A IL2

GO Terms for Glioblastoma Neural Subtype

Biological processes related to Glioblastoma Neural Subtype according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.81 STAT5B STAT5A NKX2-1 IL2
2 negative regulation of apoptotic process GO:0043066 9.72 STAT5B RPS3A IL2
3 cytokine-mediated signaling pathway GO:0019221 9.65 STAT5B STAT5A IL2
4 positive regulation of inflammatory response GO:0050729 9.54 STAT5B IL2
5 response to peptide hormone GO:0043434 9.52 STAT5B STAT5A
6 lactation GO:0007595 9.49 STAT5B STAT5A
7 interleukin-7-mediated signaling pathway GO:0038111 9.46 STAT5B STAT5A
8 JAK-STAT cascade GO:0007259 9.43 STAT5B STAT5A
9 regulation of multicellular organism growth GO:0040014 9.4 STAT5B STAT5A
10 positive regulation of activated T cell proliferation GO:0042104 9.37 STAT5B IL2
11 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.32 STAT5B STAT5A
12 interleukin-15-mediated signaling pathway GO:0035723 9.26 STAT5B STAT5A
13 interleukin-9-mediated signaling pathway GO:0038113 9.16 STAT5B STAT5A
14 taurine metabolic process GO:0019530 8.96 STAT5B STAT5A
15 interleukin-2-mediated signaling pathway GO:0038110 8.8 STAT5B STAT5A IL2

Molecular functions related to Glioblastoma Neural Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 8.8 STAT5B STAT5A NKX2-1

Sources for Glioblastoma Neural Subtype

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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