MCID: GLB012
MIFTS: 18

Glioblastoma Proneural Subtype

Categories: Cancer diseases

Aliases & Classifications for Glioblastoma Proneural Subtype

MalaCards integrated aliases for Glioblastoma Proneural Subtype:

Name: Glioblastoma Proneural Subtype 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050804

Summaries for Glioblastoma Proneural Subtype

Disease Ontology : 12 A glioblastoma multiforme that is characterized by IDH1 and p53 mutations and Platelet Derived Growth Factor A amplification.

MalaCards based summary : Glioblastoma Proneural Subtype is related to retinal cancer and sensory system cancer. An important gene associated with Glioblastoma Proneural Subtype is ALDH1A3 (Aldehyde Dehydrogenase 1 Family Member A3), and among its related pathways/superpathways are Kaposi's sarcoma-associated herpesvirus infection and Mitotic G1-G1/S phases. Related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Related Diseases for Glioblastoma Proneural Subtype

Diseases related to Glioblastoma Proneural Subtype via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 retinal cancer 9.6 CDK4 CDK6
2 sensory system cancer 9.6 CDK4 CDK6
3 ocular cancer 9.6 CDK4 CDK6
4 melanoma, cutaneous malignant 1 9.6 CDK4 CDK6
5 nervous system cancer 9.5 CDK4 CDK6
6 glioblastoma multiforme 9.5 CDK4 CDK6
7 retinoblastoma 9.4 CDK4 CDK6
8 squamous cell carcinoma, head and neck 9.3 CDK4 CDK6
9 t-cell leukemia 9.2 CDK4 CDK6
10 glioma 9.0 CDK4 CDK6

Graphical network of the top 20 diseases related to Glioblastoma Proneural Subtype:



Diseases related to Glioblastoma Proneural Subtype

Symptoms & Phenotypes for Glioblastoma Proneural Subtype

GenomeRNAi Phenotypes related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.02 CDK6
2 Decreased substrate adherent cell growth GR00193-A-2 9.02 CDK4 CDK6
3 Decreased substrate adherent cell growth GR00193-A-3 9.02 CDK4
4 Decreased substrate adherent cell growth GR00193-A-4 9.02 CDK4

MGI Mouse Phenotypes related to Glioblastoma Proneural Subtype:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 8.8 ALDH1A3 CDK4 CDK6

Drugs & Therapeutics for Glioblastoma Proneural Subtype

Search Clinical Trials , NIH Clinical Center for Glioblastoma Proneural Subtype

Genetic Tests for Glioblastoma Proneural Subtype

Anatomical Context for Glioblastoma Proneural Subtype

Publications for Glioblastoma Proneural Subtype

Variations for Glioblastoma Proneural Subtype

Expression for Glioblastoma Proneural Subtype

Search GEO for disease gene expression data for Glioblastoma Proneural Subtype.

Pathways for Glioblastoma Proneural Subtype

Pathways related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.08 CDK4 CDK6
2
Show member pathways
12.07 CDK4 CDK6
3 12.01 CDK4 CDK6
4
Show member pathways
11.93 CDK4 CDK6
5
Show member pathways
11.88 CDK4 CDK6
6 11.85 CDK4 CDK6
7
Show member pathways
11.83 CDK4 CDK6
8 11.76 CDK4 CDK6
9
Show member pathways
11.68 CDK4 CDK6
10 11.61 CDK4 CDK6
11 11.41 CDK4 CDK6
12 11.29 CDK4 CDK6
13 11.2 CDK4 CDK6
14 10.79 CDK4 CDK6
15 10.46 CDK4 CDK6
16 10.13 CDK4 CDK6

GO Terms for Glioblastoma Proneural Subtype

Cellular components related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CDK4 CDK6

Biological processes related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.32 CDK4 CDK6
2 regulation of gene expression GO:0010468 9.26 CDK4 CDK6
3 G1/S transition of mitotic cell cycle GO:0000082 9.16 CDK4 CDK6
4 positive regulation of fibroblast proliferation GO:0048146 8.96 CDK4 CDK6
5 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 8.62 CDK4 CDK6

Molecular functions related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase activity GO:0004693 8.96 CDK4 CDK6
2 cyclin binding GO:0030332 8.62 CDK4 CDK6

Sources for Glioblastoma Proneural Subtype

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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