MCID: GLB012
MIFTS: 19

Glioblastoma Proneural Subtype

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Glioblastoma Proneural Subtype

MalaCards integrated aliases for Glioblastoma Proneural Subtype:

Name: Glioblastoma Proneural Subtype 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050804

Summaries for Glioblastoma Proneural Subtype

Disease Ontology : 12 A glioblastoma multiforme that is characterized by IDH1 and p53 mutations and Platelet Derived Growth Factor A amplification.

MalaCards based summary : Glioblastoma Proneural Subtype is related to glioblastoma multiforme and glioblastoma. An important gene associated with Glioblastoma Proneural Subtype is ALDH1A3 (Aldehyde Dehydrogenase 1 Family Member A3), and among its related pathways/superpathways are Cell cycle and Cyclins and Cell Cycle Regulation. Related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Related Diseases for Glioblastoma Proneural Subtype

Diseases related to Glioblastoma Proneural Subtype via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 glioblastoma multiforme 29.8 CDK4 CDK6
2 glioblastoma 10.2
3 retinal cancer 9.9 CDK4 CDK6
4 ocular cancer 9.9 CDK4 CDK6
5 nervous system cancer 9.8 CDK4 CDK6
6 melanoma, cutaneous malignant 1 9.8 CDK4 CDK6
7 retinoblastoma 9.6 CDK4 CDK6

Graphical network of the top 20 diseases related to Glioblastoma Proneural Subtype:



Diseases related to Glioblastoma Proneural Subtype

Symptoms & Phenotypes for Glioblastoma Proneural Subtype

GenomeRNAi Phenotypes related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.35 CDK6
2 Decreased substrate adherent cell growth GR00193-A-2 9.35 CDK4 CDK6
3 Decreased substrate adherent cell growth GR00193-A-3 9.35 CDK4
4 Decreased substrate adherent cell growth GR00193-A-4 9.35 CDK4
5 shRNA abundance <= 50% GR00343-S 8.92 ALDH1A3 CDK4 CDK6 SUCLG2

MGI Mouse Phenotypes related to Glioblastoma Proneural Subtype:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 8.92 ALDH1A3 CDK4 CDK6 SUCLG2

Drugs & Therapeutics for Glioblastoma Proneural Subtype

Search Clinical Trials , NIH Clinical Center for Glioblastoma Proneural Subtype

Genetic Tests for Glioblastoma Proneural Subtype

Anatomical Context for Glioblastoma Proneural Subtype

Publications for Glioblastoma Proneural Subtype

Articles related to Glioblastoma Proneural Subtype:

# Title Authors Year
1
CDK4/6 inhibition is more active against the glioblastoma proneural subtype. ( 28903422 )
2017

Variations for Glioblastoma Proneural Subtype

Expression for Glioblastoma Proneural Subtype

Search GEO for disease gene expression data for Glioblastoma Proneural Subtype.

Pathways for Glioblastoma Proneural Subtype

GO Terms for Glioblastoma Proneural Subtype

Cellular components related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CDK4 CDK6

Biological processes related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.26 CDK4 CDK6
2 regulation of cell proliferation GO:0042127 9.16 CDK4 CDK6
3 G1/S transition of mitotic cell cycle GO:0000082 8.96 CDK4 CDK6
4 positive regulation of fibroblast proliferation GO:0048146 8.62 CDK4 CDK6

Molecular functions related to Glioblastoma Proneural Subtype according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase activity GO:0004693 8.96 CDK4 CDK6
2 cyclin binding GO:0030332 8.62 CDK4 CDK6

Sources for Glioblastoma Proneural Subtype

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....