MCID: GLF001
MIFTS: 32

Gliofibroma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Gliofibroma

MalaCards integrated aliases for Gliofibroma:

Name: Gliofibroma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4856
NCIt 50 C5419
SNOMED-CT 67 128909006
UMLS 70 C1266178

Summaries for Gliofibroma

MalaCards based summary : Gliofibroma is related to desmoplastic infantile ganglioglioma and cellular ependymoma. An important gene associated with Gliofibroma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are PI3K-Akt signaling pathway and MAPK signaling pathway. Affiliated tissues include spinal cord and cerebellum, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Gliofibroma

Diseases related to Gliofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 358)
# Related Disease Score Top Affiliating Genes
1 desmoplastic infantile ganglioglioma 30.7 SYP GFAP
2 cellular ependymoma 30.2 SYP MGMT GFAP
3 intracranial meningioma 30.2 MGMT CDKN2A
4 ganglioglioma 30.2 TP53 SYP NF1 GFAP
5 childhood pilocytic astrocytoma 30.1 NF1 KIAA1549 IDH1
6 spinal cord astrocytoma 30.1 MGMT KIAA1549 IDH1
7 low-grade astrocytoma 29.9 TP53 IDH1 CDKN2A
8 benign ependymoma 29.8 SYP NF1 KIAA1549 IDH1 GFAP
9 hydrocephalus 29.8 TP53 SYP GFAP APOE
10 mesenchymal cell neoplasm 29.6 TP53 PDGFRA KIT CD34
11 meningioma, familial 29.2 TP53 SYP PTPN11 NF1 KIAA1549 GFAP
12 malignant astrocytoma 29.1 VTN TP53 PDGFRA NF1 MGMT KIAA1549
13 pilocytic astrocytoma 28.8 TP53 SYP PTPN11 NF1 MGMT KIAA1549
14 glioblastoma 28.6 TP53 PDGFRA NF1 MGMT KIT IDH1
15 cerebral neuroblastoma 10.4 SYP GFAP
16 myocardium cancer 10.4 SYP CD99
17 lung combined type small cell carcinoma 10.4 SYP GFAP
18 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.4 SYP CD99
19 intracranial primitive neuroectodermal tumor 10.4 SYP CD99
20 papillary ependymoma 10.4 SYP GFAP
21 oligoastrocytoma 10.4 MGMT GFAP
22 optic nerve astrocytoma 10.4 SYP NF1
23 cerebellopontine angle primitive neuroectodermal tumor 10.4 SYP GFAP CD99
24 third ventricle chordoid glioma 10.4 GFAP CD34
25 ganglioneuroma 10.4 SYP GFAP CD99
26 brain sarcoma 10.3 TP53 KIAA1549
27 gangliocytoma 10.3 SYP KIAA1549 GFAP
28 urethra transitional cell carcinoma 10.3 TP53 GFAP
29 olfactory nerve neoplasm 10.3 SYP GFAP CD99
30 cranial nerve malignant neoplasm 10.3 SYP GFAP CD99
31 central nervous system mesenchymal non-meningothelial tumor 10.3 MYOD1 CD99
32 subependymoma 10.3 SYP GFAP
33 keratosis pilaris atrophicans faciei 10.3 PTPN11 NF1
34 pineocytoma 10.3 SYP GFAP
35 chiari malformation 10.3 SYP GFAP
36 sarcomatoid transitional cell carcinoma 10.3 TP53 SYP
37 glomangiomyoma 10.3 SYP CD34
38 lung meningioma 10.3 SYP CD34
39 bile duct mucinous adenocarcinoma 10.3 TP53 SYP
40 epididymal neoplasm 10.3 NF1 MYOD1
41 extraosseous ewing sarcoma 10.3 SYP MYOD1 CD99
42 spermatic cord cancer 10.3 MYOD1 CD34
43 adult brain stem glioma 10.3 MGMT IDH1
44 undifferentiated embryonal sarcoma of the liver 10.3 TP53 MYOD1
45 mechanical ectropion 10.3 NF1 CD34
46 thymic epithelial tumor 10.3 KIT CD99
47 vulva basal cell carcinoma 10.3 SYP CDKN2A
48 extraventricular neurocytoma 10.3 SYP IDH1 GFAP
49 obstructive hydrocephalus 10.3 SYP NF1 GFAP
50 vulvar eccrine porocarcinoma 10.3 SYP CDKN2A

Graphical network of the top 20 diseases related to Gliofibroma:



Diseases related to Gliofibroma

Symptoms & Phenotypes for Gliofibroma

MGI Mouse Phenotypes related to Gliofibroma:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.43 APOE CD34 CDKN2A COL1A2 EPHA2 GFAP
2 immune system MP:0005387 10.36 APOE CD34 CDKN2A COL1A2 EPHA2 GFAP
3 behavior/neurological MP:0005386 10.35 APOE B3GAT1 CDKN2A COL1A2 GFAP KIAA1549
4 hematopoietic system MP:0005397 10.31 APOE CD34 CDKN2A COL1A2 IDH1 KIT
5 cardiovascular system MP:0005385 10.3 APOE CDKN2A COL1A2 EPHA2 GFAP KIT
6 mortality/aging MP:0010768 10.3 APOE B3GAT1 CDKN2A COL1A2 EPHA2 GFAP
7 nervous system MP:0003631 10.18 APOE B3GAT1 CDKN2A COL1A2 EPHA2 GFAP
8 digestive/alimentary MP:0005381 10.15 APOE CDKN2A GFAP KIT NF1 PDGFRA
9 integument MP:0010771 10.15 APOE CD34 CDKN2A COL1A2 KIT NF1
10 muscle MP:0005369 10.13 APOE CDKN2A COL1A2 GFAP KIT MYOD1
11 neoplasm MP:0002006 10.1 CD34 CDKN2A EPHA2 KIT MGMT MYOD1
12 limbs/digits/tail MP:0005371 10.08 APOE COL1A2 EPHA2 KIT NF1 PDGFRA
13 normal MP:0002873 10.03 COL1A2 EPHA2 GFAP KIT MRC2 MYOD1
14 no phenotypic analysis MP:0003012 9.92 APOE CDKN2A KIT MGMT MYOD1 PDGFRA
15 pigmentation MP:0001186 9.7 APOE CDKN2A KIT NF1 PDGFRA PTPN11
16 respiratory system MP:0005388 9.65 APOE CDKN2A IDH1 KIT MGMT MYOD1
17 skeleton MP:0005390 9.36 APOE CDKN2A COL1A2 EPHA2 IDH1 KIT

Drugs & Therapeutics for Gliofibroma

Search Clinical Trials , NIH Clinical Center for Gliofibroma

Genetic Tests for Gliofibroma

Anatomical Context for Gliofibroma

MalaCards organs/tissues related to Gliofibroma:

40
Spinal Cord, Cerebellum

Publications for Gliofibroma

Articles related to Gliofibroma:

(show all 41)
# Title Authors PMID Year
1
Fronto-mesial-pericallosal gliofibroma. 61
29671292 2020
2
Solitary fibrous tumour of cervical spinal cord. 61
32499472 2020
3
Detection of mitochondrial DNA variants at low level heteroplasmy in pediatric CNS and extra-CNS solid tumors with three different enrichment methods. 61
31972374 2020
4
Multicentric malignant glioma with striking morphologic heterogeneity and early and extensive metastatic spread to the bone. 61
31661065 2019
5
Rare Pediatric Invasive Gliofibroma Has BRAFV600E Mutation and Transiently Responds to Targeted Therapy Before Progressive Clonal Evolution. 61
31179415 2019
6
Midbrain Gliofibroma Presenting in Adulthood following "Cure" of a Childhood Intraventricular Pilocytic Astrocytoma. 61
28245445 2017
7
Adult Intracranial Gliofibroma : A Case Report and Review of the Literature. 61
27226865 2016
8
Gliofibroma: Report of Four Cases and Review of the Literature. 61
26720861 2016
9
Erratum: WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm. 61
26612551 2015
10
WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise Commonly Misinterpreted Neoplasm. 61
26081826 2015
11
Intracranial gliofibroma: a case report and review of the literature. 61
25126436 2014
12
Disseminated spinal cord astrocytoma with features of gliofibroma: a review of the literature. 61
23320999 2013
13
Concurrent solitary fibrous tumor and low-grade fibrillary astrocytoma of the cerebellum. 61
20860893 2010
14
Lumbar intradural extramedullary gliofibroma. 61
19803106 2009
15
A case report of intraventricular gliofibroma. 61
19521134 2009
16
Gliofibroma: a report of three cases and review of literature. 61
17851847 2007
17
Cerebellar gliofibroma with numerous psammoma bodies. 61
16644412 2006
18
Intracranial gliofibroma mimicking a meningioma: a case report and review of literature. 61
16412839 2006
19
Carboplatinum and vincristine chemotherapy for central nervous system gliofibroma: case report and review of the literature. 61
15543013 2004
20
Gliofibroma: an incompletely characterized tumor. 61
15143993 2004
21
Gliofibroma: a case report and review of the literature. 61
12923349 2003
22
Gliofibroma with extensive calcified deposits. 61
12617189 2003
23
Cervical intramedullary gliofibroma in a child: a case report and review of the literature. 61
11893894 2002
24
Supratentorial desmoplastic ependymoma with giant ependymal rosettes. 61
10919350 2000
25
Monitoring tumor activity in low grade glioma of childhood. 61
9743959 1998
26
Gliofibroma: mixed glial and mesenchymal tumour. Report of three cases. 61
9746306 1998
27
Unique desmoplastic cerebral tumor in a patient with complex partial seizures. 61
10463284 1998
28
Gliofibroma: a distinct entity or a subtype of desmoplastic astrocytoma? 61
8666374 1996
29
Gliofibroma: CT and MRI. 61
7477865 1995
30
Intramedullary gliofibroma: MR, ultrasound, and pathologic correlation. 61
7622703 1995
31
Problems in the nosology of desmoplastic tumors of childhood. 61
8443097 1993
32
Gliofibromas (including malignant forms), and gliosarcomas: a comparative study and review of the literature. 61
8480509 1993
33
Desmoplastic cerebral astrocytomas of infancy: a histopathologic, immunohistochemical, ultrastructural, and molecular genetic study. 61
1468778 1992
34
[Intracerebral gliofibroma]. 61
1459023 1992
35
Gliofibroma: immunohistochemical analysis. 61
1557951 1992
36
Correspondence re: M. Vazquez, D. C. Miller, F. Epstein, et al. Glioneurofibroma: renaming the pediatric gliofibroma: a neoplasm composed of Schwann cells and astrocytes. Mod Pathol 4:519, 1991. 61
1542640 1992
37
Gliofibroma. Case report. 61
1885984 1991
38
Glioneurofibroma: renaming the pediatric "gliofibroma": a neoplasm composed of Schwann cells and astrocytes. 61
1924283 1991
39
Gliofibroma originating from temporoparietal hamartoma-like lesions. 61
6565539 1984
40
Prenatal intramedullary gliofibroma. A light and electron microscope study. 61
6695558 1984
41
Gliofibroma. A peculiar neoplasia of collagen forming glia-like cells. 61
660217 1978

Variations for Gliofibroma

Expression for Gliofibroma

Search GEO for disease gene expression data for Gliofibroma.

Pathways for Gliofibroma

GO Terms for Gliofibroma

Biological processes related to Gliofibroma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell chemotaxis GO:0060326 9.7 PDGFRA KIT EPHA2
2 positive regulation of kinase activity GO:0033674 9.69 PDGFRA KIT EPHA2
3 Ras protein signal transduction GO:0007265 9.67 TP53 NF1 CDKN2A
4 extracellular matrix organization GO:0030198 9.55 VTN PDGFRA NF1 GFAP COL1A2
5 hematopoietic progenitor cell differentiation GO:0002244 9.54 TP53 PDGFRA KIT
6 Bergmann glial cell differentiation GO:0060020 9.48 PTPN11 GFAP
7 somatic stem cell division GO:0048103 9.46 KIT CDKN2A
8 regulation of protein export from nucleus GO:0046825 9.43 PTPN11 CDKN2A
9 negative regulation of platelet activation GO:0010544 9.4 PDGFRA APOE
10 negative regulation of neuroblast proliferation GO:0007406 9.32 TP53 NF1
11 regulation of blood vessel endothelial cell migration GO:0043535 9.26 NF1 EPHA2
12 regulation of protein complex assembly GO:0043254 9.13 PTPN11 GFAP APOE
13 negative regulation of blood coagulation GO:0030195 8.8 VTN CD34 APOE

Molecular functions related to Gliofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet-derived growth factor binding GO:0048407 9.16 PDGFRA COL1A2
2 MDM2/MDM4 family protein binding GO:0097371 8.96 TP53 CDKN2A
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 PDGFRA KIT EPHA2

Sources for Gliofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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