GLM2
MCID: GLM025
MIFTS: 19

Glioma Susceptibility 2 (GLM2)

Categories: Cancer diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Glioma Susceptibility 2

MalaCards integrated aliases for Glioma Susceptibility 2:

Name: Glioma Susceptibility 2 58 30 13 6
Glm2 58 76
Glioma, Susceptibility, Type 2 41
Glioma 2 76

Classifications:



External Ids:

OMIM 58 613028
MeSH 45 D005910
MedGen 43 C2751642

Summaries for Glioma Susceptibility 2

UniProtKB/Swiss-Prot : 76 Glioma 2: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.

MalaCards based summary : Glioma Susceptibility 2, also known as glm2, is related to meningioma, familial and glioma. An important gene associated with Glioma Susceptibility 2 is PTEN (Phosphatase And Tensin Homolog). The drugs Immunoglobulins and Antibodies, Monoclonal have been mentioned in the context of this disorder.

Description from OMIM: 613028

Related Diseases for Glioma Susceptibility 2

Diseases in the Glioma Susceptibility 1 family:

Glioma Susceptibility 4 Glioma Susceptibility 2
Glioma Susceptibility 3 Glioma Susceptibility 5
Glioma Susceptibility 6 Glioma Susceptibility 7
Glioma Susceptibility 8 Glioma Susceptibility 9

Diseases related to Glioma Susceptibility 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 meningioma, familial 11.2
2 glioma 9.7
3 nasal glial heterotopia 9.7

Symptoms & Phenotypes for Glioma Susceptibility 2

Clinical features from OMIM:

613028

Drugs & Therapeutics for Glioma Susceptibility 2

Drugs for Glioma Susceptibility 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Antibodies, Monoclonal Phase 3
3 Antibodies Phase 3
4 Immunologic Factors Phase 3
5 Antirheumatic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Subcutaneous Golimumab (GLM) Plus DMARDs for Rheumatoid Arthritis, Followed by Intravenous/Subcutaneous GLM Strategy (P06129 AM2) Completed NCT00975130 Phase 3

Search NIH Clinical Center for Glioma Susceptibility 2

Genetic Tests for Glioma Susceptibility 2

Genetic tests related to Glioma Susceptibility 2:

# Genetic test Affiliating Genes
1 Glioma Susceptibility 2 30 PTEN

Anatomical Context for Glioma Susceptibility 2

Publications for Glioma Susceptibility 2

Articles related to Glioma Susceptibility 2:

# Title Authors Year
1
Commentary: Awake Transcortical Approach Resection of Dominant Posterior Cingulate Gyrus Glioma: 2-Dimensional Operative Video. ( 30888022 )
2019
2
Awake Transcortical Approach Resection of Dominant Posterior Cingulate Gyrus Glioma: 2-Dimensional Operative Video. ( 30496564 )
2018
3
Left Pan-Hippocampal Low Grade Glioma-2-Stage Transsylvian Transventricular and Paramedian Supracerebellar Transtentorial Approaches: 2-Dimensional Operative Video. ( 30295907 )
2018
4
Nasal glioma; 2 cases with recurrence. ( 14770609 )
1950

Variations for Glioma Susceptibility 2

UniProtKB/Swiss-Prot genetic disease variations for Glioma Susceptibility 2:

76
# Symbol AA change Variation ID SNP ID
1 PTEN p.Arg234Gln VAR_018106 rs121909235

ClinVar genetic disease variations for Glioma Susceptibility 2:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 PTEN NM_000314.6(PTEN): c.701G> A (p.Arg234Gln) single nucleotide variant Uncertain significance rs121909235 GRCh37 Chromosome 10, 89717676: 89717676
2 PTEN NM_000314.6(PTEN): c.701G> A (p.Arg234Gln) single nucleotide variant Uncertain significance rs121909235 GRCh38 Chromosome 10, 87957919: 87957919
3 PTEN NM_000314.7(PTEN): c.235G> A (p.Ala79Thr) single nucleotide variant Likely benign rs202004587 GRCh37 Chromosome 10, 89690828: 89690828
4 PTEN NM_000314.7(PTEN): c.235G> A (p.Ala79Thr) single nucleotide variant Likely benign rs202004587 GRCh38 Chromosome 10, 87931071: 87931071
5 PTEN NM_000314.6(PTEN): c.882T> G (p.Ser294Arg) single nucleotide variant Uncertain significance rs143335584 GRCh37 Chromosome 10, 89720731: 89720731
6 PTEN NM_000314.6(PTEN): c.882T> G (p.Ser294Arg) single nucleotide variant Uncertain significance rs143335584 GRCh38 Chromosome 10, 87960974: 87960974
7 PTEN NM_000314.6(PTEN): c.892C> G (p.Gln298Glu) single nucleotide variant Uncertain significance rs371387815 GRCh37 Chromosome 10, 89720741: 89720741
8 PTEN NM_000314.6(PTEN): c.892C> G (p.Gln298Glu) single nucleotide variant Uncertain significance rs371387815 GRCh38 Chromosome 10, 87960984: 87960984

Cosmic variations for Glioma Susceptibility 2:

9 (show top 50) (show all 6855)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM40802 ZW10 central nervous system,NS,glioma,astrocytoma Grade IV c.2140C>T p.P714S 11:113736699-113736699 0
2 COSM40801 ZSWIM4 central nervous system,NS,glioma,astrocytoma Grade IV c.266C>T p.P89L 19:13799832-13799832 0
3 COSM6932117 ZRSR2 central nervous system,NS,glioma,astrocytoma Grade IV c.271G>A p.E91K 23:15803755-15803755 0
4 COSM6948317 ZRSR2 central nervous system,NS,glioma,astrocytoma Grade IV c.340C>T p.Q114* 23:15804138-15804138 0
5 COSM6959574 ZRSR2 central nervous system,NS,glioma,astrocytoma Grade IV c.260G>A p.R87K 23:15803744-15803744 0
6 COSM6932118 ZRSR2 central nervous system,NS,glioma,astrocytoma Grade IV c.961C>T p.P321S 23:15822754-15822754 0
7 COSM6973162 ZRSR2 central nervous system,NS,glioma,oligodendroglioma Grade III c.220G>A p.E74K 23:15803704-15803704 0
8 COSM39611 ZPLD1 central nervous system,NS,glioma,astrocytoma Grade IV c.393A>T p.G131G 3:102456210-102456210 0
9 COSM40237 ZNF687 central nervous system,NS,glioma,astrocytoma Grade IV c.3651C>T p.T1217T 1:151291146-151291146 0
10 COSM39318 ZNF687 central nervous system,NS,glioma,astrocytoma Grade IV c.2044T>A p.C682S 1:151288335-151288335 0
11 COSM39317 ZNF687 central nervous system,NS,glioma,astrocytoma Grade IV c.2043G>C p.Q681H 1:151288334-151288334 0
12 COSM39149 ZNF507 central nervous system,NS,glioma,astrocytoma Grade IV c.1517G>C p.R506T 19:32354347-32354347 0
13 COSM40794 ZNF473 central nervous system,NS,glioma,astrocytoma Grade IV c.42C>T p.D14D 19:50039193-50039193 0
14 COSM39217 ZMYND8 central nervous system,NS,glioma,astrocytoma Grade IV c.2162T>G p.V721G 20:47246130-47246130 0
15 COSM40504 ZMYND8 central nervous system,NS,glioma,astrocytoma Grade IV c.2176G>A p.D726N 20:47246116-47246116 0
16 COSM5977723 ZMYM2 central nervous system,NS,glioma,astrocytoma Grade IV c.1134-1G>T p.? 13:20005073-20005073 0
17 COSM5977724 ZMYM2 central nervous system,NS,glioma,astrocytoma Grade IV c.1134-1G>T p.? 13:20005073-20005073 0
18 COSM39507 ZMAT4 central nervous system,NS,glioma,astrocytoma Grade IV c.76G>A p.E26K 8:40825601-40825601 0
19 COSM6976869 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade IV c.4279G>A p.A1427T 16:72798403-72798403 0
20 COSM6929045 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade IV c.3607G>T p.E1203* 16:72811961-72811961 0
21 COSM6950242 ZFHX3 central nervous system,NS,glioma,oligodendroglioma Grade III c.8300G>A p.G2767E 16:72794382-72794382 0
22 COSM6959528 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade IV c.145C>T p.P49S 16:72960001-72960001 0
23 COSM5385367 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade IV c.934G>A p.D312N 16:72959212-72959212 0
24 COSM6980194 ZFHX3 central nervous system,NS,glioma,oligodendroglioma Grade III c.6025T>C p.Y2009H 16:72796657-72796657 0
25 COSM5981027 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade IV c.8647A>G p.M2883V 16:72794035-72794035 0
26 COSM3888943 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade IV c.8198G>A p.R2733H 16:72794484-72794484 0
27 COSM6973145 ZFHX3 central nervous system,NS,glioma,oligodendroglioma Grade III c.3986G>A p.G1329E 16:72798696-72798696 0
28 COSM6976663 ZFHX3 central nervous system,NS,glioma,oligodendroglioma Grade III c.8600C>T p.S2867F 16:72794082-72794082 0
29 COSM6968504 ZFHX3 central nervous system,NS,glioma,oligodendroglioma Grade III c.2680G>A p.D894N 16:72957466-72957466 0
30 COSM6976870 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade IV c.461G>A p.G154E 16:72959685-72959685 0
31 COSM6948292 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade IV c.1819G>A p.E607K 16:72958327-72958327 0
32 COSM6968503 ZFHX3 central nervous system,NS,glioma,oligodendroglioma Grade III c.9154G>A p.V3052I 16:72793528-72793528 0
33 COSM40870 ZFC3H1 central nervous system,NS,glioma,astrocytoma Grade IV c.1055G>A p.S352N 12:71647774-71647774 0
34 COSM40793 ZFAT central nervous system,NS,glioma,astrocytoma Grade IV c.1006G>A p.V336M 8:134602677-134602677 0
35 COSM40680 ZEB1 central nervous system,NS,glioma,astrocytoma Grade IV c.1913C>T p.S638L 10:31521248-31521248 0
36 COSM41152 ZC3H6 central nervous system,NS,glioma,astrocytoma Grade IV c.2254G>T p.G752* 2:112331172-112331172 0
37 COSM40778 ZBTB4 central nervous system,NS,glioma,astrocytoma Grade IV c.2842C>T p.L948F 17:7462140-7462140 0
38 COSM40777 ZBTB24 central nervous system,NS,glioma,astrocytoma Grade IV c.1886C>T p.P629L 6:109466059-109466059 0
39 COSM39508 ZBTB21 central nervous system,NS,glioma,astrocytoma Grade IV c.997G>A p.G333S 21:41993099-41993099 0
40 COSM40776 ZBTB16 central nervous system,NS,glioma,astrocytoma Grade IV c.413C>T p.A138V 11:114063713-114063713 0
41 COSM41039 YWHAH central nervous system,NS,glioma,astrocytoma Grade IV c.169C>T p.R57* 22:31956220-31956220 0
42 COSM40774 YTHDC2 central nervous system,NS,glioma,astrocytoma Grade IV c.782C>T p.A261V 5:113532985-113532985 0
43 COSM4440509 YES1 central nervous system,NS,glioma,astrocytoma Grade IV c.832C>T p.R278* 18:743308-743308 0
44 COSM6913717 YES1 central nervous system,NS,glioma,astrocytoma Grade IV c.1153G>A p.A385T 18:736946-736946 0
45 COSM6919634 YES1 central nervous system,NS,glioma,oligodendroglioma Grade III c.259G>C p.A87P 18:756569-756569 0
46 COSM6962767 YAP1 central nervous system,NS,glioma,astrocytoma Grade IV c.538G>A p.A180T 11:102114360-102114360 0
47 COSM6931893 YAP1 central nervous system,NS,glioma,astrocytoma Grade IV c.1007C>T p.T336I 11:102227474-102227474 0
48 COSM6928995 YAP1 central nervous system,NS,glioma,astrocytoma Grade IV c.842G>A p.R281Q 11:102206046-102206046 0
49 COSM6976817 XRCC2 central nervous system,NS,glioma,astrocytoma Grade IV c.365G>A p.S122N 7:152649120-152649120 0
50 COSM39272 XPO7 central nervous system,NS,glioma,astrocytoma Grade IV c.1157G>A p.R386Q 8:21982692-21982692 0

Expression for Glioma Susceptibility 2

Search GEO for disease gene expression data for Glioma Susceptibility 2.

Pathways for Glioma Susceptibility 2

GO Terms for Glioma Susceptibility 2

Sources for Glioma Susceptibility 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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