GLM2
MCID: GLM025
MIFTS: 20

Glioma Susceptibility 2 (GLM2)

Categories: Cancer diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Glioma Susceptibility 2

MalaCards integrated aliases for Glioma Susceptibility 2:

Name: Glioma Susceptibility 2 58 30 13 6
Glm2 58 76
Glioma, Susceptibility, Type 2 41
Glioma 2 76

Classifications:



External Ids:

OMIM 58 613028
MeSH 45 D005910
MedGen 43 C2751642

Summaries for Glioma Susceptibility 2

UniProtKB/Swiss-Prot : 76 Glioma 2: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.

MalaCards based summary : Glioma Susceptibility 2, also known as glm2, is related to meningioma, familial and glioma. An important gene associated with Glioma Susceptibility 2 is PTEN (Phosphatase And Tensin Homolog). The drugs Immunologic Factors and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include brain.

Description from OMIM: 613028

Related Diseases for Glioma Susceptibility 2

Diseases in the Glioma Susceptibility 1 family:

Glioma Susceptibility 4 Glioma Susceptibility 2
Glioma Susceptibility 3 Glioma Susceptibility 5
Glioma Susceptibility 6 Glioma Susceptibility 7
Glioma Susceptibility 8 Glioma Susceptibility 9

Diseases related to Glioma Susceptibility 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 meningioma, familial 11.2
2 glioma 9.7
3 nasal glial heterotopia 9.7

Symptoms & Phenotypes for Glioma Susceptibility 2

Clinical features from OMIM:

613028

Drugs & Therapeutics for Glioma Susceptibility 2

Drugs for Glioma Susceptibility 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 3
2 Immunoglobulins Phase 3
3 Antibodies, Monoclonal Phase 3
4 Antirheumatic Agents Phase 3
5 Antibodies Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Subcutaneous Golimumab (GLM) Plus DMARDs for Rheumatoid Arthritis, Followed by Intravenous/Subcutaneous GLM Strategy (P06129 AM2) Completed NCT00975130 Phase 3

Search NIH Clinical Center for Glioma Susceptibility 2

Genetic Tests for Glioma Susceptibility 2

Genetic tests related to Glioma Susceptibility 2:

# Genetic test Affiliating Genes
1 Glioma Susceptibility 2 30 PTEN

Anatomical Context for Glioma Susceptibility 2

MalaCards organs/tissues related to Glioma Susceptibility 2:

42
Brain

Publications for Glioma Susceptibility 2

Articles related to Glioma Susceptibility 2:

# Title Authors Year
1
Commentary: Awake Transcortical Approach Resection of Dominant Posterior Cingulate Gyrus Glioma: 2-Dimensional Operative Video. ( 30888022 )
2019
2
Left Pan-Hippocampal Low Grade Glioma-2-Stage Transsylvian Transventricular and Paramedian Supracerebellar Transtentorial Approaches: 2-Dimensional Operative Video. ( 30295907 )
2019
3
Awake Transcortical Approach Resection of Dominant Posterior Cingulate Gyrus Glioma: 2-Dimensional Operative Video. ( 30496564 )
2018
4
A novel germline mutation of PTEN associated with brain tumours of multiple lineages. ( 12085208 )
2002
5
Nasal glioma; 2 cases with recurrence. ( 14770609 )
1950

Variations for Glioma Susceptibility 2

UniProtKB/Swiss-Prot genetic disease variations for Glioma Susceptibility 2:

76
# Symbol AA change Variation ID SNP ID
1 PTEN p.Arg234Gln VAR_018106 rs121909235

ClinVar genetic disease variations for Glioma Susceptibility 2:

6 (show all 40)
# Gene Variation Type Significance SNP ID Assembly Location
1 PTEN NM_000314.6(PTEN): c.1003C> T (p.Arg335Ter) single nucleotide variant Pathogenic rs121909231 GRCh37 Chromosome 10, 89720852: 89720852
2 PTEN NM_000314.6(PTEN): c.1003C> T (p.Arg335Ter) single nucleotide variant Pathogenic rs121909231 GRCh38 Chromosome 10, 87961095: 87961095
3 PTEN NM_000314.7(PTEN): c.701G> A (p.Arg234Gln) single nucleotide variant Uncertain significance rs121909235 GRCh37 Chromosome 10, 89717676: 89717676
4 PTEN NM_000314.7(PTEN): c.701G> A (p.Arg234Gln) single nucleotide variant Uncertain significance rs121909235 GRCh38 Chromosome 10, 87957919: 87957919
5 PTEN NM_000314.4(PTEN): c.-764G> A single nucleotide variant Uncertain significance rs587776674 GRCh37 Chromosome 10, 89623462: 89623462
6 PTEN NM_000314.4(PTEN): c.-764G> A single nucleotide variant Uncertain significance rs587776674 GRCh38 Chromosome 10, 87863705: 87863705
7 PTEN NM_000314.7(PTEN): c.235G> A (p.Ala79Thr) single nucleotide variant Likely benign rs202004587 GRCh37 Chromosome 10, 89690828: 89690828
8 PTEN NM_000314.7(PTEN): c.235G> A (p.Ala79Thr) single nucleotide variant Likely benign rs202004587 GRCh38 Chromosome 10, 87931071: 87931071
9 PTEN NM_000314.4(PTEN): c.-1190G> A single nucleotide variant Uncertain significance rs587779982 GRCh37 Chromosome 10, 89623036: 89623036
10 PTEN NM_000314.4(PTEN): c.-1190G> A single nucleotide variant Uncertain significance rs587779982 GRCh38 Chromosome 10, 87863279: 87863279
11 PTEN NM_000314.4(PTEN): c.-834C> T single nucleotide variant Uncertain significance rs587779994 GRCh37 Chromosome 10, 89623392: 89623392
12 PTEN NM_000314.4(PTEN): c.-834C> T single nucleotide variant Uncertain significance rs587779994 GRCh38 Chromosome 10, 87863635: 87863635
13 PTEN NM_000314.4(PTEN): c.-943C> T single nucleotide variant Uncertain significance rs587779999 GRCh37 Chromosome 10, 89623283: 89623283
14 PTEN NM_000314.4(PTEN): c.-943C> T single nucleotide variant Uncertain significance rs587779999 GRCh38 Chromosome 10, 87863526: 87863526
15 PTEN NM_000314.6(PTEN): c.882T> G (p.Ser294Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs143335584 GRCh37 Chromosome 10, 89720731: 89720731
16 PTEN NM_000314.6(PTEN): c.882T> G (p.Ser294Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs143335584 GRCh38 Chromosome 10, 87960974: 87960974
17 PTEN NM_000314.6(PTEN): c.892C> G (p.Gln298Glu) single nucleotide variant Uncertain significance rs371387815 GRCh37 Chromosome 10, 89720741: 89720741
18 PTEN NM_000314.6(PTEN): c.892C> G (p.Gln298Glu) single nucleotide variant Uncertain significance rs371387815 GRCh38 Chromosome 10, 87960984: 87960984
19 PTEN NM_000314.6(PTEN): c.914G> A (p.Ser305Asn) single nucleotide variant Uncertain significance rs587780007 GRCh37 Chromosome 10, 89720763: 89720763
20 PTEN NM_000314.6(PTEN): c.914G> A (p.Ser305Asn) single nucleotide variant Uncertain significance rs587780007 GRCh38 Chromosome 10, 87961006: 87961006
21 PTEN NM_000314.4(PTEN): c.-868G> C single nucleotide variant Uncertain significance rs587782133 GRCh37 Chromosome 10, 89623358: 89623358
22 PTEN NM_000314.4(PTEN): c.-868G> C single nucleotide variant Uncertain significance rs587782133 GRCh38 Chromosome 10, 87863601: 87863601
23 PTEN NM_000314.4(PTEN): c.-1154G> A single nucleotide variant Uncertain significance rs786203674 GRCh37 Chromosome 10, 89623072: 89623072
24 PTEN NM_000314.4(PTEN): c.-1154G> A single nucleotide variant Uncertain significance rs786203674 GRCh38 Chromosome 10, 87863315: 87863315
25 PTEN NM_000314.6(PTEN): c.-665G> A single nucleotide variant Uncertain significance rs553371022 GRCh37 Chromosome 10, 89623561: 89623561
26 PTEN NM_000314.6(PTEN): c.-665G> A single nucleotide variant Uncertain significance rs553371022 GRCh38 Chromosome 10, 87863804: 87863804
27 PTEN NM_000314.6(PTEN): c.517C> T (p.Arg173Cys) single nucleotide variant Pathogenic rs121913293 GRCh37 Chromosome 10, 89711899: 89711899
28 PTEN NM_000314.6(PTEN): c.517C> T (p.Arg173Cys) single nucleotide variant Pathogenic rs121913293 GRCh38 Chromosome 10, 87952142: 87952142
29 PTEN NM_000314.6(PTEN): c.860C> G (p.Ser287Ter) single nucleotide variant Pathogenic/Likely pathogenic rs863224909 GRCh38 Chromosome 10, 87960952: 87960952
30 PTEN NM_000314.6(PTEN): c.860C> G (p.Ser287Ter) single nucleotide variant Pathogenic/Likely pathogenic rs863224909 GRCh37 Chromosome 10, 89720709: 89720709
31 PTEN NM_000314.4(PTEN): c.-821G> T single nucleotide variant Uncertain significance rs587779993 GRCh38 Chromosome 10, 87863648: 87863648
32 PTEN NM_000314.4(PTEN): c.-821G> T single nucleotide variant Uncertain significance rs587779993 GRCh37 Chromosome 10, 89623405: 89623405
33 PTEN NM_000314.6(PTEN): c.404T> A (p.Ile135Lys) single nucleotide variant Likely pathogenic rs370795352 GRCh38 Chromosome 10, 87933163: 87933163
34 PTEN NM_000314.6(PTEN): c.404T> A (p.Ile135Lys) single nucleotide variant Likely pathogenic rs370795352 GRCh37 Chromosome 10, 89692920: 89692920
35 PTEN NM_000314.6(PTEN): c.253+2T> A single nucleotide variant Pathogenic/Likely pathogenic rs1224040268 GRCh37 Chromosome 10, 89690848: 89690848
36 PTEN NM_000314.6(PTEN): c.253+2T> A single nucleotide variant Pathogenic/Likely pathogenic rs1224040268 GRCh38 Chromosome 10, 87931091: 87931091
37 PTEN NM_000314.6(PTEN): c.862G> A (p.Glu288Lys) single nucleotide variant Uncertain significance rs1554825528 GRCh38 Chromosome 10, 87960954: 87960954
38 PTEN NM_000314.6(PTEN): c.862G> A (p.Glu288Lys) single nucleotide variant Uncertain significance rs1554825528 GRCh37 Chromosome 10, 89720711: 89720711
39 PTEN NM_000314.4(PTEN): c.-1246C> G single nucleotide variant Uncertain significance rs1554889801 GRCh37 Chromosome 10, 89622980: 89622980
40 PTEN NM_000314.4(PTEN): c.-1246C> G single nucleotide variant Uncertain significance rs1554889801 GRCh38 Chromosome 10, 87863223: 87863223

Cosmic variations for Glioma Susceptibility 2:

9 (show top 50) (show all 6870)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM40802 ZW10 central nervous system,NS,glioma,astrocytoma Grade I c.2140C>T p.P714S 11:113736699-113736699 0
2 COSM40801 ZSWIM4 central nervous system,NS,glioma,astrocytoma Grade I c.266C>T p.P89L 19:13799832-13799832 0
3 COSM6932117 ZRSR2 central nervous system,NS,glioma,astrocytoma Grade I c.271G>A p.E91K 23:15803755-15803755 0
4 COSM6948317 ZRSR2 central nervous system,NS,glioma,astrocytoma Grade I c.340C>T p.Q114* 23:15804138-15804138 0
5 COSM6959574 ZRSR2 central nervous system,NS,glioma,astrocytoma Grade I c.260G>A p.R87K 23:15803744-15803744 0
6 COSM6932118 ZRSR2 central nervous system,NS,glioma,astrocytoma Grade I c.961C>T p.P321S 23:15822754-15822754 0
7 COSM6973162 ZRSR2 central nervous system,NS,glioma,oligodendroglioma Grade III c.220G>A p.E74K 23:15803704-15803704 0
8 COSM39611 ZPLD1 central nervous system,NS,glioma,astrocytoma Grade I c.393A>T p.G131G 3:102456210-102456210 0
9 COSM40237 ZNF687 central nervous system,NS,glioma,astrocytoma Grade I c.3651C>T p.T1217T 1:151291146-151291146 0
10 COSM39318 ZNF687 central nervous system,NS,glioma,astrocytoma Grade I c.2044T>A p.C682S 1:151288335-151288335 0
11 COSM39317 ZNF687 central nervous system,NS,glioma,astrocytoma Grade I c.2043G>C p.Q681H 1:151288334-151288334 0
12 COSM39149 ZNF507 central nervous system,NS,glioma,astrocytoma Grade I c.1517G>C p.R506T 19:32354347-32354347 0
13 COSM40794 ZNF473 central nervous system,NS,glioma,astrocytoma Grade I c.42C>T p.D14D 19:50039193-50039193 0
14 COSM39217 ZMYND8 central nervous system,NS,glioma,astrocytoma Grade I c.2162T>G p.V721G 20:47246130-47246130 0
15 COSM40504 ZMYND8 central nervous system,NS,glioma,astrocytoma Grade I c.2176G>A p.D726N 20:47246116-47246116 0
16 COSM5977723 ZMYM2 central nervous system,NS,glioma,astrocytoma Grade I c.1134-1G>T p.? 13:20005073-20005073 0
17 COSM5977724 ZMYM2 central nervous system,NS,glioma,astrocytoma Grade I c.1134-1G>T p.? 13:20005073-20005073 0
18 COSM39507 ZMAT4 central nervous system,NS,glioma,astrocytoma Grade I c.76G>A p.E26K 8:40825601-40825601 0
19 COSM6976869 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade I c.4279G>A p.A1427T 16:72798403-72798403 0
20 COSM6929045 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade I c.3607G>T p.E1203* 16:72811961-72811961 0
21 COSM6950242 ZFHX3 central nervous system,NS,glioma,oligodendroglioma Grade III c.8300G>A p.G2767E 16:72794382-72794382 0
22 COSM6959528 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade I c.145C>T p.P49S 16:72960001-72960001 0
23 COSM5385367 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade I c.934G>A p.D312N 16:72959212-72959212 0
24 COSM6980194 ZFHX3 central nervous system,NS,glioma,oligodendroglioma Grade III c.6025T>C p.Y2009H 16:72796657-72796657 0
25 COSM5981027 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade I c.8647A>G p.M2883V 16:72794035-72794035 0
26 COSM3888943 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade I c.8198G>A p.R2733H 16:72794484-72794484 0
27 COSM6973145 ZFHX3 central nervous system,NS,glioma,oligodendroglioma Grade III c.3986G>A p.G1329E 16:72798696-72798696 0
28 COSM6976663 ZFHX3 central nervous system,NS,glioma,oligodendroglioma Grade III c.8600C>T p.S2867F 16:72794082-72794082 0
29 COSM6968504 ZFHX3 central nervous system,NS,glioma,oligodendroglioma Grade III c.2680G>A p.D894N 16:72957466-72957466 0
30 COSM6976870 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade I c.461G>A p.G154E 16:72959685-72959685 0
31 COSM6948292 ZFHX3 central nervous system,NS,glioma,astrocytoma Grade I c.1819G>A p.E607K 16:72958327-72958327 0
32 COSM6968503 ZFHX3 central nervous system,NS,glioma,oligodendroglioma Grade III c.9154G>A p.V3052I 16:72793528-72793528 0
33 COSM40870 ZFC3H1 central nervous system,NS,glioma,astrocytoma Grade I c.1055G>A p.S352N 12:71647774-71647774 0
34 COSM40793 ZFAT central nervous system,NS,glioma,astrocytoma Grade I c.1006G>A p.V336M 8:134602677-134602677 0
35 COSM40680 ZEB1 central nervous system,NS,glioma,astrocytoma Grade I c.1913C>T p.S638L 10:31521248-31521248 0
36 COSM41152 ZC3H6 central nervous system,NS,glioma,astrocytoma Grade I c.2254G>T p.G752* 2:112331172-112331172 0
37 COSM40778 ZBTB4 central nervous system,NS,glioma,astrocytoma Grade I c.2842C>T p.L948F 17:7462140-7462140 0
38 COSM40777 ZBTB24 central nervous system,NS,glioma,astrocytoma Grade I c.1886C>T p.P629L 6:109466059-109466059 0
39 COSM39508 ZBTB21 central nervous system,NS,glioma,astrocytoma Grade I c.997G>A p.G333S 21:41993099-41993099 0
40 COSM40776 ZBTB16 central nervous system,NS,glioma,astrocytoma Grade I c.413C>T p.A138V 11:114063713-114063713 0
41 COSM41039 YWHAH central nervous system,NS,glioma,astrocytoma Grade I c.169C>T p.R57* 22:31956220-31956220 0
42 COSM40774 YTHDC2 central nervous system,NS,glioma,astrocytoma Grade I c.782C>T p.A261V 5:113532985-113532985 0
43 COSM4440509 YES1 central nervous system,NS,glioma,astrocytoma Grade I c.832C>T p.R278* 18:743308-743308 0
44 COSM6913717 YES1 central nervous system,NS,glioma,astrocytoma Grade I c.1153G>A p.A385T 18:736946-736946 0
45 COSM6919634 YES1 central nervous system,NS,glioma,oligodendroglioma Grade III c.259G>C p.A87P 18:756569-756569 0
46 COSM6931893 YAP1 central nervous system,NS,glioma,astrocytoma Grade I c.1007C>T p.T336I 11:102227474-102227474 0
47 COSM6928995 YAP1 central nervous system,NS,glioma,astrocytoma Grade I c.842G>A p.R281Q 11:102206046-102206046 0
48 COSM6962767 YAP1 central nervous system,NS,glioma,astrocytoma Grade I c.538G>A p.A180T 11:102114360-102114360 0
49 COSM6976817 XRCC2 central nervous system,NS,glioma,astrocytoma Grade I c.365G>A p.S122N 7:152649120-152649120 0
50 COSM39272 XPO7 central nervous system,NS,glioma,astrocytoma Grade I c.1157G>A p.R386Q 8:21982692-21982692 0

Expression for Glioma Susceptibility 2

Search GEO for disease gene expression data for Glioma Susceptibility 2.

Pathways for Glioma Susceptibility 2

GO Terms for Glioma Susceptibility 2

Sources for Glioma Susceptibility 2

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